ZA200702793B - Humanized anti-5T4 antibodies and anti-5T4 antibody/calicheamicin conjugates - Google Patents
Humanized anti-5T4 antibodies and anti-5T4 antibody/calicheamicin conjugatesInfo
- Publication number
- ZA200702793B ZA200702793B ZA200702793A ZA200702793A ZA200702793B ZA 200702793 B ZA200702793 B ZA 200702793B ZA 200702793 A ZA200702793 A ZA 200702793A ZA 200702793 A ZA200702793 A ZA 200702793A ZA 200702793 B ZA200702793 B ZA 200702793B
- Authority
- ZA
- South Africa
- Prior art keywords
- antibodies
- antibody
- calicheamicin conjugates
- humanized
- humanized anti
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3023—Lung
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60849404P | 2004-09-10 | 2004-09-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200702793B true ZA200702793B (en) | 2010-09-29 |
Family
ID=35811702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200702793A ZA200702793B (en) | 2004-09-10 | 2007-04-03 | Humanized anti-5T4 antibodies and anti-5T4 antibody/calicheamicin conjugates |
Country Status (22)
Country | Link |
---|---|
US (3) | US20060088522A1 (fr) |
EP (1) | EP1786469A2 (fr) |
JP (1) | JP2008512485A (fr) |
KR (1) | KR20070050956A (fr) |
CN (1) | CN101035564A (fr) |
AR (1) | AR050642A1 (fr) |
AU (1) | AU2005285152A1 (fr) |
BR (1) | BRPI0515113A (fr) |
CA (1) | CA2578131A1 (fr) |
CR (1) | CR8958A (fr) |
EC (1) | ECSP077310A (fr) |
GT (1) | GT200500255A (fr) |
IL (1) | IL181625A0 (fr) |
MX (1) | MX2007002826A (fr) |
NO (1) | NO20071436L (fr) |
PA (1) | PA8645301A1 (fr) |
PE (2) | PE20060817A1 (fr) |
RU (1) | RU2007108716A (fr) |
SV (1) | SV2007002227A (fr) |
TW (1) | TW200616662A (fr) |
WO (1) | WO2006031653A2 (fr) |
ZA (1) | ZA200702793B (fr) |
Families Citing this family (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
JP2006510735A (ja) * | 2002-08-19 | 2006-03-30 | ジェネンテック・インコーポレーテッド | 腫瘍の診断と治療のための組成物と方法 |
TW200539855A (en) * | 2004-03-15 | 2005-12-16 | Wyeth Corp | Calicheamicin conjugates |
TW200621282A (en) * | 2004-08-13 | 2006-07-01 | Wyeth Corp | Stabilizing formulations |
TW200635607A (en) | 2004-12-15 | 2006-10-16 | Elan Pharm Inc | Humanized Aβ antibodies for use in improving cognition |
MX2008011492A (es) * | 2006-03-10 | 2008-09-22 | Wyeth Corp | Anticuerpos anti-5t4 y usos de los mismos. |
CN101506235B (zh) | 2006-09-01 | 2012-07-25 | 人类多细胞株治疗学公司 | 人或人源化免疫球蛋白在非人转基因动物中增强的表达 |
WO2008045563A2 (fr) * | 2006-10-12 | 2008-04-17 | Wyeth | Procédés et compositions ayant une opalescence réduite |
JP2010516678A (ja) * | 2007-01-16 | 2010-05-20 | ワイス エルエルシー | Trem−1による炎症治療、検出およびモニタリング |
PE20090309A1 (es) * | 2007-06-04 | 2009-04-18 | Wyeth Corp | Conjugado portador-caliqueamicina y un metodo de deteccion de caliqueamicina |
JO3076B1 (ar) * | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
AU2016208353B2 (en) * | 2007-10-17 | 2017-07-20 | Janssen Alzheimer Immunotherapy | Immunotherapy regimes dependent on ApoE status |
ES2883176T3 (es) | 2007-11-08 | 2021-12-07 | Prec Biologics Inc | Anticuerpos monoclonales recombinantes y antígenos correspondientes para cánceres de colon y de páncreas |
ME03057B (fr) | 2007-12-07 | 2019-01-20 | Zymogenetics Inc | Molécules d'anticorps humanisés spécifiques pour l'IL-31 |
FR2930443B1 (fr) | 2008-04-29 | 2010-06-25 | Oreal | Produit extemporane de soin a base d'un lyophilisat de microorganisme et de tensioactif(s) de hlb superieur ou egal a 12 |
CN102083859B (zh) * | 2008-05-07 | 2014-09-17 | 阿哥斯医疗公司 | 人源化抗人干扰素-α抗体 |
GB0822836D0 (en) * | 2008-12-15 | 2009-01-21 | Oxford Biomedica Ltd | Method |
ES2565439T3 (es) * | 2009-01-09 | 2016-04-04 | Oxford Biomedica (Uk) Ltd | Factores |
JP5788863B2 (ja) | 2009-03-27 | 2015-10-07 | ワイス・エルエルシー | 腫瘍開始細胞およびその使用方法 |
JP5820800B2 (ja) | 2010-03-02 | 2015-11-24 | 協和発酵キリン株式会社 | 改変抗体組成物 |
AR085091A1 (es) | 2011-01-26 | 2013-09-11 | Kolltan Pharmaceuticals Inc | Anticuerpos anti-kit y sus usos |
JP2014510080A (ja) * | 2011-03-09 | 2014-04-24 | セントローズ, エルエルシー | 細胞外標的化薬物複合体 |
AU2012228100B2 (en) | 2011-03-17 | 2016-09-08 | The University Of Birmingham | Re-directed immunotherapy |
KR101783529B1 (ko) | 2011-04-01 | 2017-09-29 | 와이어쓰 엘엘씨 | 항체-약물 접합체 |
BR112013028907A2 (pt) | 2011-05-08 | 2017-01-31 | Legochem Biosciences Inc | conjugados de proteína-agente ativo e método para preparar os mesmos |
JP2014533929A (ja) * | 2011-09-23 | 2014-12-18 | アムゲン リサーチ (ミュンヘン) ゲーエムベーハー | 5t4およびcd3に対する二重特異的結合性分子 |
WO2013068874A1 (fr) * | 2011-11-11 | 2013-05-16 | Pfizer Inc. | Conjugués anticorps-médicament |
MX361058B (es) * | 2012-01-24 | 2018-11-23 | Pfizer | Método para detectar células tumorales circulantes 5t4-positivas y métodos de diagnóstico de cáncer 5t4-positivo en un sujeto mamífero. |
GB201203442D0 (en) | 2012-02-28 | 2012-04-11 | Univ Birmingham | Immunotherapeutic molecules and uses |
EP2861617A1 (fr) * | 2012-06-15 | 2015-04-22 | Pfizer Inc. | Anticorps antagonistes améliorés dirigés contre gdf-8 et leurs utilisations |
CA2880007C (fr) | 2012-07-25 | 2021-12-28 | Kolltan Pharmaceuticals, Inc. | Anticorps anti-kit et leurs utilisations |
US9221908B2 (en) | 2012-12-12 | 2015-12-29 | Vasculox, Inc. | Therapeutic CD47 antibodies |
CN105102479B (zh) | 2012-12-12 | 2019-06-28 | 瓦斯库劳克斯有限公司 | 治疗性cd47抗体 |
KR102572149B1 (ko) | 2013-10-11 | 2023-08-30 | 아사나 바이오사이언시스 엘엘씨 | 단백질-폴리머-약물 접합체 |
BR112016007736B1 (pt) | 2013-10-11 | 2022-09-27 | Mersana Therapeutics, Inc | Armação polimérica, e, composição farmacêutica |
JP2016540826A (ja) | 2013-11-04 | 2016-12-28 | ファイザー・インク | 抗efna4抗体−薬物コンジュゲート |
EP3122371A4 (fr) * | 2014-03-28 | 2017-09-06 | New York University | Protéines de fusion fgf23 |
WO2015155345A1 (fr) * | 2014-04-11 | 2015-10-15 | Medimmune Limited | Anticorps et conjugués anticorps-médicament |
SG11201609372UA (en) | 2014-05-22 | 2016-12-29 | Synthon Biopharmaceuticals Bv | Site-specific conjugation of linker drugs to antibodies and resulting adcs |
KR101628872B1 (ko) | 2014-05-28 | 2016-06-09 | 주식회사 레고켐 바이오사이언스 | 자가-희생 기를 포함하는 화합물 |
EP3954703A3 (fr) | 2014-05-29 | 2022-05-18 | MacroGenics, Inc. | Molécules de liaison trispécifiques et leurs procédés d'utilisation |
US10759868B2 (en) | 2014-09-04 | 2020-09-01 | Cellectis | Trophoblast glycoprotein (5T4, TPBG) specific chimeric antigen receptors for cancer immunotherapy |
GB201501004D0 (en) | 2015-01-21 | 2015-03-04 | Cancer Rec Tech Ltd | Inhibitors |
CN107427590B (zh) | 2015-02-02 | 2021-08-31 | 伯明翰大学 | 具有多个t细胞表位的靶向部分肽表位复合物 |
CA2978847A1 (fr) * | 2015-04-17 | 2016-10-20 | Arsanis Biosciences Gmbh | Anticorps diriges contre les proteines de liaison a l'immunoglobuline de s. aureus |
CA2929542A1 (fr) * | 2015-05-13 | 2016-11-13 | Pfizer Inc. | Traitement au moyen de conjugues de medicaments anticorps anti-efna4 |
CN116425875A (zh) | 2015-09-18 | 2023-07-14 | 安驰肿瘤公司 | 治疗性cd47抗体 |
WO2017051249A1 (fr) * | 2015-09-25 | 2017-03-30 | Legochem Biosciences, Inc. | Compositions et méthodes associées à des conjugués anticorps anti-cd19-médicaments |
WO2017051254A1 (fr) * | 2015-09-25 | 2017-03-30 | Legochem Biosciences, Inc. | Compositions et méthodes associées à des conjugués anticorps anti-egfr-médicaments |
EP3184547A1 (fr) * | 2015-10-29 | 2017-06-28 | F. Hoffmann-La Roche AG | Anticorps anti-tpbg et procédés d'utilisation |
AU2016358296B2 (en) | 2015-11-19 | 2020-05-21 | Revitope Limited | Functional antibody fragment complementation for a two-components system for redirected killing of unwanted cells |
PL3380122T3 (pl) | 2015-11-24 | 2021-12-13 | Byondis B.V. | Przeciwciała anty-5T4 i koniugaty przeciwciało-lek |
WO2017089895A1 (fr) | 2015-11-25 | 2017-06-01 | Legochem Biosciences, Inc. | Conjugués anticorps-médicament comprenant des lieurs ramifiés et procédés connexes |
CA3006247A1 (fr) | 2015-11-25 | 2017-06-01 | Legochem Biosciences, Inc. | Conjugues comprenant des groupes peptidiques et procedes associes a ceux-ci |
CA3006242A1 (fr) | 2015-11-25 | 2017-06-01 | Legochem Biosciences, Inc. | Conjugues comprenant des groupes auto-immolables et procedes associes |
EP3399989B1 (fr) * | 2015-12-16 | 2023-08-09 | Merck Sharp & Dohme LLC | Anticorps anti-lag3 et fragments de fixation à l'antigène |
JP2019508023A (ja) * | 2015-12-24 | 2019-03-28 | エックスディーシーエクスプローラー (シャンハイ) カンパニー リミテッド | Tpbg抗体およびその調製方法、その共役体並び用途 |
US20170281758A1 (en) * | 2016-03-29 | 2017-10-05 | Sorrento Therapeutics, Inc. | Calicheamicin antibody drug conjugates linking an amidoacetyl group to a sugar moiety on calicheamicin |
KR102426765B1 (ko) | 2016-04-22 | 2022-07-29 | 엘리게이터 바이오사이언스 에이비 | Cd137에 대한 신규한 이중특이성 폴리펩타이드 |
GB201611530D0 (en) | 2016-07-01 | 2016-08-17 | Alligator Bioscience Ab | Novel polypeptides |
EP3529276A4 (fr) | 2016-10-21 | 2020-06-17 | Arch Oncology, Inc. | Anticorps cd47 thérapeutiques |
US11135307B2 (en) | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
CN108084265B (zh) * | 2016-11-23 | 2021-07-02 | 复旦大学 | 特异性结合人的5t4抗原的全人源单域抗体及其应用 |
JP7277388B2 (ja) | 2017-03-15 | 2023-05-18 | オックスフォード バイオメディカ(ユーケー)リミテッド | 方法 |
IL269535B1 (en) | 2017-03-29 | 2024-07-01 | Ligachem Biosciences Inc | Meters drug pyrrolobenzodiazepine dimer and its ligand-binding conjugate compound |
WO2018184558A1 (fr) * | 2017-04-05 | 2018-10-11 | 凯惠科技发展(上海)有限公司 | Anticorps anti-tpbg humanisé, son procédé de préparation, conjugué de celui-ci et applications |
CN111148763B (zh) | 2017-07-20 | 2023-11-03 | Aptevo研究与开发公司 | 结合于5t4和4-1bb的抗原结合蛋白以及相关组合物和方法 |
US11638760B2 (en) | 2017-11-27 | 2023-05-02 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
JP2021506883A (ja) | 2017-12-21 | 2021-02-22 | メルサナ セラピューティクス インコーポレイテッド | ピロロベンゾジアゼピン抗体結合体 |
CN108187065B (zh) * | 2017-12-29 | 2023-04-28 | 广东众生药业股份有限公司 | 抗5t4抗体与美登素衍生物dm4偶联复合物及制备方法和用途 |
EP3765493A2 (fr) | 2018-03-12 | 2021-01-20 | Genmab A/S | Anticorps |
CN108642070B (zh) * | 2018-04-11 | 2022-03-15 | 沈阳金石生物制药有限公司 | 特异性诱导肿瘤细胞凋亡的重组人Fc抗体及其制备方法、用途 |
SG11202010443WA (en) | 2018-05-09 | 2020-11-27 | Legochem Biosciences Inc | Compositions and methods related to anti-cd19 antibody drug conjugates |
WO2020092385A1 (fr) | 2018-10-29 | 2020-05-07 | Mersana Therapeutics, Inc. | Conjugués anticorps-médicament modifiés par une cystéine avec des lieurs contenant des peptides |
WO2020127376A2 (fr) | 2018-12-17 | 2020-06-25 | Alligator Bioscience Ab | Nouveaux polypeptides |
EP3898679A2 (fr) | 2018-12-17 | 2021-10-27 | Alligator Bioscience AB | Polypeptides |
KR20210028544A (ko) | 2019-09-04 | 2021-03-12 | 주식회사 레고켐 바이오사이언스 | 인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도 |
US20230257479A1 (en) | 2019-09-12 | 2023-08-17 | Genmab A/S | Bispecific antibodies binding to 5t4 and cd3 for use in treatment of cancer |
WO2022106869A1 (fr) | 2019-11-22 | 2022-05-27 | Medimmune Limited | Protéines de fusion comprenant un domaine de conjugaison e2 ubiquitine ou de type ubiquitine et un domaine de ciblage destiné à la dégradation spécifique de protéines |
WO2021207657A1 (fr) * | 2020-04-09 | 2021-10-14 | Cytomx Therapeutics, Inc. | Compositions contenant des anticorps activables |
KR20240049285A (ko) | 2021-08-26 | 2024-04-16 | 쿄와 기린 가부시키가이샤 | Cd116 및 cd131에 결합하는 이중 특이적 항체 |
WO2023083919A1 (fr) | 2021-11-09 | 2023-05-19 | Tubulis Gmbh | Conjugués comprenant un phosphore (v) et un fragment de camptothécine |
WO2023155925A1 (fr) * | 2022-02-21 | 2023-08-24 | Concept To Medicine Biotech Co., Ltd. | Anticorps anti-5t4 et leurs utilisations |
GB202219154D0 (en) | 2022-12-19 | 2023-02-01 | Metacurum Biotech Ab | Antibodies and uses thereof |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4671958A (en) * | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
US4970198A (en) * | 1985-10-17 | 1990-11-13 | American Cyanamid Company | Antitumor antibiotics (LL-E33288 complex) |
US4670198A (en) * | 1985-06-17 | 1987-06-02 | General Electric Company | Binder system for the manufacture of nuclear fuel pellets, and the method and product thereof |
US5037651A (en) * | 1987-01-30 | 1991-08-06 | American Cyanamid Company | Dihydro derivatives of LL-E33288 antibiotics |
US5108912A (en) * | 1987-01-30 | 1992-04-28 | American Cyanamid Company | Antitumor antibiotics (LL-E33288 complex) |
US5079233A (en) * | 1987-01-30 | 1992-01-07 | American Cyanamid Company | N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same |
US5606040A (en) * | 1987-10-30 | 1997-02-25 | American Cyanamid Company | Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group |
US5053394A (en) * | 1988-09-21 | 1991-10-01 | American Cyanamid Company | Targeted forms of methyltrithio antitumor agents |
US5869053A (en) * | 1988-03-04 | 1999-02-09 | Cancer Research Campaign Technology, Ltd. | 5T4 antigen from human trophoblasts |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5773001A (en) * | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
WO2001036486A2 (fr) * | 1999-11-18 | 2001-05-25 | Oxford Biomedica (Uk) Limited | Anticorps |
US6852703B1 (en) * | 1997-06-04 | 2005-02-08 | Oxford Biomedica (Uk) Limited | Tumor targeted vector |
US7148035B1 (en) * | 1998-11-18 | 2006-12-12 | Oxford Biomedica (Uk) Limited | Polypeptide |
US20030035798A1 (en) * | 2000-08-16 | 2003-02-20 | Fang Fang | Humanized antibodies |
ATE269357T1 (de) * | 1999-04-28 | 2004-07-15 | Univ Texas | Zusammensetzungen und verfahren zur krebsbehandlung durch die selektive hemmung von vegf |
GB0126378D0 (en) * | 2001-11-02 | 2002-01-02 | Oxford Biomedica Ltd | Antigen |
ES2545745T3 (es) * | 2002-05-02 | 2015-09-15 | Wyeth Holdings Llc | Conjugados de transportador derivado de caliqueamicina |
TW200539855A (en) * | 2004-03-15 | 2005-12-16 | Wyeth Corp | Calicheamicin conjugates |
-
2005
- 2005-09-09 BR BRPI0515113-9A patent/BRPI0515113A/pt not_active IP Right Cessation
- 2005-09-09 TW TW094130985A patent/TW200616662A/zh unknown
- 2005-09-09 WO PCT/US2005/032196 patent/WO2006031653A2/fr active Application Filing
- 2005-09-09 PE PE2005001053A patent/PE20060817A1/es not_active Application Discontinuation
- 2005-09-09 US US11/221,902 patent/US20060088522A1/en not_active Abandoned
- 2005-09-09 AR ARP050103781A patent/AR050642A1/es not_active Application Discontinuation
- 2005-09-09 CN CNA200580033531XA patent/CN101035564A/zh active Pending
- 2005-09-09 JP JP2007531375A patent/JP2008512485A/ja active Pending
- 2005-09-09 CA CA002578131A patent/CA2578131A1/fr not_active Abandoned
- 2005-09-09 RU RU2007108716/13A patent/RU2007108716A/ru not_active Application Discontinuation
- 2005-09-09 AU AU2005285152A patent/AU2005285152A1/en not_active Abandoned
- 2005-09-09 PE PE2009001172A patent/PE20100251A1/es not_active Application Discontinuation
- 2005-09-09 GT GT200500255A patent/GT200500255A/es unknown
- 2005-09-09 MX MX2007002826A patent/MX2007002826A/es not_active Application Discontinuation
- 2005-09-09 PA PA20058645301A patent/PA8645301A1/es unknown
- 2005-09-09 EP EP05813090A patent/EP1786469A2/fr not_active Ceased
- 2005-09-09 KR KR1020077005677A patent/KR20070050956A/ko not_active Application Discontinuation
- 2005-09-09 SV SV2005002227A patent/SV2007002227A/es not_active Application Discontinuation
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2007
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- 2007-03-09 EC EC2007007310A patent/ECSP077310A/es unknown
- 2007-03-16 NO NO20071436A patent/NO20071436L/no not_active Application Discontinuation
- 2007-04-03 ZA ZA200702793A patent/ZA200702793B/xx unknown
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2009
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- 2009-10-16 US US12/580,702 patent/US20100173382A1/en not_active Abandoned
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US20060088522A1 (en) | 2006-04-27 |
MX2007002826A (es) | 2007-04-27 |
AU2005285152A1 (en) | 2006-03-23 |
GT200500255A (es) | 2006-04-10 |
SV2007002227A (es) | 2007-03-20 |
CN101035564A (zh) | 2007-09-12 |
PA8645301A1 (es) | 2006-07-03 |
ECSP077310A (es) | 2007-04-26 |
BRPI0515113A (pt) | 2008-07-01 |
US20100021483A1 (en) | 2010-01-28 |
WO2006031653A3 (fr) | 2006-05-04 |
EP1786469A2 (fr) | 2007-05-23 |
KR20070050956A (ko) | 2007-05-16 |
AR050642A1 (es) | 2006-11-08 |
PE20100251A1 (es) | 2010-04-10 |
IL181625A0 (en) | 2007-07-04 |
JP2008512485A (ja) | 2008-04-24 |
CR8958A (es) | 2007-10-04 |
WO2006031653A2 (fr) | 2006-03-23 |
RU2007108716A (ru) | 2008-10-20 |
US20100173382A1 (en) | 2010-07-08 |
NO20071436L (no) | 2007-06-08 |
CA2578131A1 (fr) | 2006-03-23 |
TW200616662A (en) | 2006-06-01 |
PE20060817A1 (es) | 2006-10-10 |
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