ZA200400380B - Substituted napthyl indole derivatives as inhibitors of plasminogen activator inhibitor Type-1 (PAl-1) - Google Patents
Substituted napthyl indole derivatives as inhibitors of plasminogen activator inhibitor Type-1 (PAl-1) Download PDFInfo
- Publication number
- ZA200400380B ZA200400380B ZA200400380A ZA200400380A ZA200400380B ZA 200400380 B ZA200400380 B ZA 200400380B ZA 200400380 A ZA200400380 A ZA 200400380A ZA 200400380 A ZA200400380 A ZA 200400380A ZA 200400380 B ZA200400380 B ZA 200400380B
- Authority
- ZA
- South Africa
- Prior art keywords
- carbons
- compound
- pentyl
- pharmaceutically acceptable
- alkyl
- Prior art date
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- 150000002475 indoles Chemical class 0.000 title description 8
- 239000003112 inhibitor Substances 0.000 title description 5
- 101150072055 PAL1 gene Proteins 0.000 title description 3
- 102000010752 Plasminogen Inactivators Human genes 0.000 title description 2
- 108010077971 Plasminogen Inactivators Proteins 0.000 title description 2
- 229940054051 antipsychotic indole derivative Drugs 0.000 title description 2
- 239000002797 plasminogen activator inhibitor Substances 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 138
- 125000000217 alkyl group Chemical group 0.000 claims description 50
- 150000003839 salts Chemical class 0.000 claims description 48
- 238000000034 method Methods 0.000 claims description 42
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- 239000001257 hydrogen Substances 0.000 claims description 34
- 125000004432 carbon atom Chemical group C* 0.000 claims description 26
- 239000000203 mixture Substances 0.000 claims description 25
- 150000002431 hydrogen Chemical class 0.000 claims description 24
- 125000003118 aryl group Chemical group 0.000 claims description 22
- 125000003545 alkoxy group Chemical group 0.000 claims description 21
- 150000002148 esters Chemical group 0.000 claims description 19
- 229910052736 halogen Inorganic materials 0.000 claims description 19
- 150000002367 halogens Chemical group 0.000 claims description 19
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- 238000011282 treatment Methods 0.000 claims description 18
- 125000001589 carboacyl group Chemical group 0.000 claims description 17
- 239000002253 acid Substances 0.000 claims description 14
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Classifications
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Landscapes
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Applications Claiming Priority (1)
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US29965101P | 2001-06-20 | 2001-06-20 |
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ZA200400380A ZA200400380B (en) | 2001-06-20 | 2004-01-19 | Substituted napthyl indole derivatives as inhibitors of plasminogen activator inhibitor Type-1 (PAl-1) |
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US (4) | US6800654B2 (no) |
EP (1) | EP1397356B1 (no) |
JP (1) | JP4520144B2 (no) |
KR (1) | KR20040007744A (no) |
CN (1) | CN1280288C (no) |
AR (1) | AR036101A1 (no) |
AT (1) | ATE431346T1 (no) |
AU (1) | AU2002316533B2 (no) |
BR (1) | BR0210504A (no) |
CA (1) | CA2448798C (no) |
CO (1) | CO5540286A2 (no) |
DE (1) | DE60232328D1 (no) |
EA (1) | EA009696B1 (no) |
EC (1) | ECSP034904A (no) |
ES (1) | ES2325733T3 (no) |
HU (1) | HUP0400233A3 (no) |
IL (1) | IL159449A0 (no) |
MX (1) | MXPA03011522A (no) |
NO (2) | NO326316B1 (no) |
NZ (1) | NZ530312A (no) |
PL (1) | PL367525A1 (no) |
TW (1) | TWI224101B (no) |
UA (1) | UA78708C2 (no) |
WO (1) | WO2003000684A1 (no) |
ZA (1) | ZA200400380B (no) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
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TWI224101B (en) * | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
US7291639B2 (en) * | 2001-06-20 | 2007-11-06 | Wyeth | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
DE60221391T2 (de) | 2001-06-20 | 2008-04-17 | Wyeth | Substituierte indolsäurederivate als inhibitoren von plasminogen-aktivator-inhibitor-1 (pai-1) |
JP2006510673A (ja) * | 2002-12-10 | 2006-03-30 | ワイス | プラスミノゲンアクティベータインヒビター1(pai−1)のインヒビターとしての、アリール、アリールオキシ、および、アルキルオキシ置換1h−インドール−3−イルグリオキシル酸誘導体 |
CN1726191A (zh) * | 2002-12-10 | 2006-01-25 | 惠氏公司 | 用作纤溶酶原激活物抑制剂-1(pai-1)的抑制剂的取代的吲哚氧代-乙酰氨基乙酸衍生物 |
CA2509238A1 (en) * | 2002-12-10 | 2004-06-24 | Wyeth | Substituted 3-carbonyl-1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
UA80453C2 (en) * | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
EP1569899B1 (en) * | 2002-12-10 | 2006-06-28 | Wyeth | Substituted 3-alkyl- and 3-arylalkyl-1h-indol-1-yl-acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
JP4390460B2 (ja) * | 2003-02-21 | 2009-12-24 | 株式会社静岡カフェイン工業所 | オキサゾール誘導体 |
US7582773B2 (en) * | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
US7351726B2 (en) * | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
US7163954B2 (en) * | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
US7534894B2 (en) * | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
US7446201B2 (en) * | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
US7442805B2 (en) * | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
US7141592B2 (en) * | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
US7420083B2 (en) * | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
US7342039B2 (en) * | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
US7332521B2 (en) * | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
US7411083B2 (en) * | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
US7265148B2 (en) * | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
US7268159B2 (en) * | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
US7115815B2 (en) * | 2003-10-31 | 2006-10-03 | Adc Telecommunications, Inc. | Cable utilizing varying lay length mechanisms to minimize alien crosstalk |
AU2005277139A1 (en) * | 2004-08-23 | 2006-03-02 | Wyeth | Thiazolo-naphthyl acids as inhibitors of plasminogen activator inhibitor-1 |
AU2005277138A1 (en) * | 2004-08-23 | 2006-03-02 | Wyeth Holdings Corporation | Oxazolo-naphthyl acids as plaminogen activator inhibtor type-1 (PAI-1) modulators useful in the treatment of thrombosis and cardiovascular diseases |
MX2007002177A (es) * | 2004-08-23 | 2007-04-02 | Wyeth Corp | Acidos de pirrolo-naftilo como inhibidores de pai-1. |
AU2006208021A1 (en) * | 2005-01-27 | 2006-08-03 | Wyeth | Processes and compounds for the preparation of substituted naphthylindole derivatives |
BRPI0614340A2 (pt) * | 2005-08-17 | 2011-04-12 | Wyeth Corp | indóis substituìdos e métodos de seu uso |
US20070203220A1 (en) * | 2006-02-27 | 2007-08-30 | Wyeth | Inhibitors Of PAI-1 For Treatment Of Muscular Conditions |
EP2080751A4 (en) | 2006-10-12 | 2011-06-22 | Inst Med Molecular Design Inc | CARBOXYLIC ACID DERIVATIVE |
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