ZA200307964B - Substituted dimethyl-[1-(1-phenyl-cyclohexyl)-piperidin-3-yl methyl]-amines and the use of the same as analgesics. - Google Patents
Substituted dimethyl-[1-(1-phenyl-cyclohexyl)-piperidin-3-yl methyl]-amines and the use of the same as analgesics. Download PDFInfo
- Publication number
- ZA200307964B ZA200307964B ZA200307964A ZA200307964A ZA200307964B ZA 200307964 B ZA200307964 B ZA 200307964B ZA 200307964 A ZA200307964 A ZA 200307964A ZA 200307964 A ZA200307964 A ZA 200307964A ZA 200307964 B ZA200307964 B ZA 200307964B
- Authority
- ZA
- South Africa
- Prior art keywords
- phenyl
- piperidin
- cyclohexyl
- dimethylaminomethyl
- formula
- Prior art date
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- YDJWSFJCRATAJZ-UHFFFAOYSA-N n,n-dimethyl-1-[1-(1-phenylcyclohexyl)piperidin-3-yl]methanamine Chemical class C1C(CN(C)C)CCCN1C1(C=2C=CC=CC=2)CCCCC1 YDJWSFJCRATAJZ-UHFFFAOYSA-N 0.000 title claims description 10
- 229940035676 analgesics Drugs 0.000 title description 3
- 239000000730 antalgic agent Substances 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 35
- 238000006243 chemical reaction Methods 0.000 claims description 22
- 238000002360 preparation method Methods 0.000 claims description 13
- IJOOHPMOJXWVHK-UHFFFAOYSA-N chlorotrimethylsilane Chemical compound C[Si](C)(C)Cl IJOOHPMOJXWVHK-UHFFFAOYSA-N 0.000 claims description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
- 239000002585 base Substances 0.000 claims description 7
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 5
- 150000001412 amines Chemical class 0.000 claims description 5
- 239000012458 free base Substances 0.000 claims description 5
- HDMXAJXGRQIGPI-UHFFFAOYSA-N 4-benzyl-3-[(dimethylamino)methyl]-1-(1-phenylcyclohexyl)piperidin-4-ol;dihydrochloride Chemical compound Cl.Cl.CN(C)CC1CN(C2(CCCCC2)C=2C=CC=CC=2)CCC1(O)CC1=CC=CC=C1 HDMXAJXGRQIGPI-UHFFFAOYSA-N 0.000 claims description 4
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- VVDUZZGYBOWDSQ-UHFFFAOYSA-M eschenmoser's salt Chemical compound [I-].C[N+](C)=C VVDUZZGYBOWDSQ-UHFFFAOYSA-M 0.000 claims description 3
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- 238000000034 method Methods 0.000 claims description 3
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- -1 dihydrochloride 4- (3-chloro-phenyl)-3-dimethylaminomethyl-1-(l-phenyl- cyclohexyl) -piperidin Chemical compound 0.000 claims description 2
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- CBBJPBBLZXMNBI-UHFFFAOYSA-N 3-[(dimethylamino)methyl]-4-ethyl-1-(1-phenylcyclohexyl)piperidin-4-ol;dihydrochloride Chemical compound Cl.Cl.C1C(CN(C)C)C(CC)(O)CCN1C1(C=2C=CC=CC=2)CCCCC1 CBBJPBBLZXMNBI-UHFFFAOYSA-N 0.000 claims 1
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- 238000011200 topical administration Methods 0.000 description 1
- 229960003107 tramadol hydrochloride Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10112198A DE10112198A1 (de) | 2001-03-14 | 2001-03-14 | Substituierte Dimethyl-[1-(1-phenyl-cyclohexyl)-piperidin-3-ylmethyl]-amine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200307964B true ZA200307964B (en) | 2004-09-14 |
Family
ID=7677392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200307964A ZA200307964B (en) | 2001-03-14 | 2003-10-13 | Substituted dimethyl-[1-(1-phenyl-cyclohexyl)-piperidin-3-yl methyl]-amines and the use of the same as analgesics. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7049327B2 (cs) |
| EP (1) | EP1370529B1 (cs) |
| JP (1) | JP2004526726A (cs) |
| KR (1) | KR20040012733A (cs) |
| CN (1) | CN1496352A (cs) |
| AT (1) | ATE315551T1 (cs) |
| BR (1) | BR0208243A (cs) |
| CA (1) | CA2440758A1 (cs) |
| CZ (1) | CZ20032455A3 (cs) |
| DE (2) | DE10112198A1 (cs) |
| DK (1) | DK1370529T3 (cs) |
| EC (1) | ECSP034768A (cs) |
| ES (1) | ES2256499T3 (cs) |
| HU (1) | HUP0302800A2 (cs) |
| IL (1) | IL157893A0 (cs) |
| MX (1) | MXPA03007967A (cs) |
| NO (1) | NO20034029L (cs) |
| PE (1) | PE20020926A1 (cs) |
| PL (1) | PL364415A1 (cs) |
| RU (1) | RU2003129061A (cs) |
| SK (1) | SK11122003A3 (cs) |
| WO (1) | WO2002072550A1 (cs) |
| ZA (1) | ZA200307964B (cs) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105646332B (zh) * | 2014-11-09 | 2018-05-25 | 复旦大学 | 氨基甲基哌啶类衍生物及其制备方法和药物用途 |
| KR102603671B1 (ko) | 2017-01-17 | 2023-11-17 | 메비아스 디스커버리 인코포레이티드 | 치환된 3-디알킬아미노메틸-피페리딘-4-일-벤즈아미드 및 이를 제조 및 사용하는 방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL40064A0 (en) * | 1972-08-07 | 1972-10-29 | Univ Tel Aviv | Phencyclidine and its derivatives as short-time acting midriatics |
| US4598153A (en) * | 1984-12-19 | 1986-07-01 | The United States Of America As Represented By The Department Of Health And Human Services | Metaphit, a specific acylating agent for the [3 H] phencyclidine |
| US5155212A (en) * | 1986-05-21 | 1992-10-13 | Abbott Laboratories | Phencyclidine and phencyclidine metabolites assay, tracers, immunogens, antibodies and reagent kit |
| ATE212981T1 (de) * | 1994-09-30 | 2002-02-15 | Novartis Erfind Verwalt Gmbh | 1-acyl-4-aliphatische aminopiperidin verbindungen |
| AU8024998A (en) * | 1997-06-03 | 1998-12-21 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Novel phencyclidine derivatives, preparation methods and pharmaceutical compositions containing same |
| ID29137A (id) * | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
| DE10000312A1 (de) * | 2000-01-05 | 2001-07-12 | Gruenenthal Gmbh | Substituierte Aminomethyl-Phenyl-Cyclohexanderivate |
-
2001
- 2001-03-14 DE DE10112198A patent/DE10112198A1/de not_active Withdrawn
-
2002
- 2002-03-13 RU RU2003129061/04A patent/RU2003129061A/ru not_active Application Discontinuation
- 2002-03-13 CA CA002440758A patent/CA2440758A1/en not_active Abandoned
- 2002-03-13 SK SK1112-2003A patent/SK11122003A3/sk unknown
- 2002-03-13 KR KR10-2003-7011908A patent/KR20040012733A/ko not_active Withdrawn
- 2002-03-13 PL PL02364415A patent/PL364415A1/xx unknown
- 2002-03-13 PE PE2002000199A patent/PE20020926A1/es not_active Application Discontinuation
- 2002-03-13 IL IL15789302A patent/IL157893A0/xx unknown
- 2002-03-13 WO PCT/EP2002/002723 patent/WO2002072550A1/de not_active Ceased
- 2002-03-13 EP EP02750542A patent/EP1370529B1/de not_active Expired - Lifetime
- 2002-03-13 HU HU0302800A patent/HUP0302800A2/hu unknown
- 2002-03-13 ES ES02750542T patent/ES2256499T3/es not_active Expired - Lifetime
- 2002-03-13 DE DE50205593T patent/DE50205593D1/de not_active Expired - Lifetime
- 2002-03-13 BR BR0208243-8A patent/BR0208243A/pt not_active Application Discontinuation
- 2002-03-13 CN CNA028064135A patent/CN1496352A/zh active Pending
- 2002-03-13 JP JP2002571466A patent/JP2004526726A/ja not_active Withdrawn
- 2002-03-13 DK DK02750542T patent/DK1370529T3/da active
- 2002-03-13 MX MXPA03007967A patent/MXPA03007967A/es not_active Application Discontinuation
- 2002-03-13 CZ CZ20032455A patent/CZ20032455A3/cs unknown
- 2002-03-13 AT AT02750542T patent/ATE315551T1/de active
-
2003
- 2003-09-11 NO NO20034029A patent/NO20034029L/no not_active Application Discontinuation
- 2003-09-12 EC EC2003004768A patent/ECSP034768A/es unknown
- 2003-09-12 US US10/660,729 patent/US7049327B2/en not_active Expired - Fee Related
- 2003-10-13 ZA ZA200307964A patent/ZA200307964B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1370529A1 (de) | 2003-12-17 |
| IL157893A0 (en) | 2004-03-28 |
| US20040127516A1 (en) | 2004-07-01 |
| RU2003129061A (ru) | 2005-04-10 |
| DE50205593D1 (de) | 2006-04-06 |
| PE20020926A1 (es) | 2002-10-26 |
| NO20034029L (no) | 2003-11-13 |
| HUP0302800A2 (hu) | 2003-11-28 |
| ES2256499T3 (es) | 2006-07-16 |
| DE10112198A1 (de) | 2002-09-19 |
| CN1496352A (zh) | 2004-05-12 |
| US7049327B2 (en) | 2006-05-23 |
| CZ20032455A3 (cs) | 2003-12-17 |
| PL364415A1 (en) | 2004-12-13 |
| MXPA03007967A (es) | 2004-10-15 |
| KR20040012733A (ko) | 2004-02-11 |
| CA2440758A1 (en) | 2002-09-19 |
| SK11122003A3 (sk) | 2004-01-08 |
| NO20034029D0 (no) | 2003-09-11 |
| ATE315551T1 (de) | 2006-02-15 |
| EP1370529B1 (de) | 2006-01-11 |
| ECSP034768A (es) | 2003-10-28 |
| JP2004526726A (ja) | 2004-09-02 |
| DK1370529T3 (da) | 2006-05-22 |
| WO2002072550A1 (de) | 2002-09-19 |
| BR0208243A (pt) | 2004-03-09 |
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