ZA200209230B - An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof. - Google Patents

An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof. Download PDF

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Publication number
ZA200209230B
ZA200209230B ZA200209230A ZA200209230A ZA200209230B ZA 200209230 B ZA200209230 B ZA 200209230B ZA 200209230 A ZA200209230 A ZA 200209230A ZA 200209230 A ZA200209230 A ZA 200209230A ZA 200209230 B ZA200209230 B ZA 200209230B
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South Africa
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antibody
cells
tra
drs
cell
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ZA200209230A
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English (en)
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Tong Zhou
Kimihisa Ichikawa
Robert P Kimberly
William J Koopman
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Uab Research Foundation
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • AHUMAN NECESSITIES
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • AHUMAN NECESSITIES
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    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07ORGANIC CHEMISTRY
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    • C07K2319/00Fusion polypeptide
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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ZA200209230A 2000-05-02 2002-11-13 An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof. ZA200209230B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20134400P 2000-05-02 2000-05-02

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ZA200209230B true ZA200209230B (en) 2004-03-16

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US (6) US7244429B2 (de)
EP (4) EP1287035B1 (de)
JP (4) JP4156238B2 (de)
KR (2) KR20060092292A (de)
CN (2) CN100497388C (de)
AT (1) ATE426615T1 (de)
AU (2) AU5936601A (de)
BG (3) BG109275A (de)
BR (1) BR0110547A (de)
CA (1) CA2407965C (de)
CY (1) CY1109179T1 (de)
CZ (2) CZ306996B6 (de)
DE (1) DE60138097D1 (de)
DK (1) DK1287035T3 (de)
EE (1) EE05548B1 (de)
ES (1) ES2323448T3 (de)
HK (3) HK1050372A1 (de)
HU (2) HU230399B1 (de)
IL (1) IL152605A0 (de)
MX (1) MXPA02010823A (de)
NO (2) NO329843B1 (de)
NZ (1) NZ522881A (de)
PL (1) PL211733B1 (de)
PT (1) PT1287035E (de)
RU (1) RU2298013C2 (de)
TW (1) TWI318983B (de)
WO (1) WO2001083560A1 (de)
ZA (1) ZA200209230B (de)

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