ZA200202694B - Farnesyl transferase inhibitors. - Google Patents
Farnesyl transferase inhibitors. Download PDFInfo
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- ZA200202694B ZA200202694B ZA200202694A ZA200202694A ZA200202694B ZA 200202694 B ZA200202694 B ZA 200202694B ZA 200202694 A ZA200202694 A ZA 200202694A ZA 200202694 A ZA200202694 A ZA 200202694A ZA 200202694 B ZA200202694 B ZA 200202694B
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- South Africa
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- ester
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- 230000000699 topical effect Effects 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 229940044693 topoisomerase inhibitor Drugs 0.000 description 1
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 description 1
- 229960000303 topotecan Drugs 0.000 description 1
- 229960005026 toremifene Drugs 0.000 description 1
- XFCLJVABOIYOMF-QPLCGJKRSA-N toremifene Chemical compound C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 XFCLJVABOIYOMF-QPLCGJKRSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 description 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9930318.2A GB9930318D0 (en) | 1999-12-22 | 1999-12-22 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200202694B true ZA200202694B (en) | 2003-12-31 |
Family
ID=10866834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200202694A ZA200202694B (en) | 1999-12-22 | 2002-04-05 | Farnesyl transferase inhibitors. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7101897B2 (no) |
| EP (1) | EP1255733B1 (no) |
| JP (1) | JP3742593B2 (no) |
| KR (1) | KR20020063251A (no) |
| CN (2) | CN1680313A (no) |
| AR (1) | AR029460A1 (no) |
| AT (1) | ATE316074T1 (no) |
| AU (1) | AU776003B2 (no) |
| BR (1) | BR0016669A (no) |
| CA (1) | CA2387579A1 (no) |
| CO (1) | CO5360641A1 (no) |
| CZ (1) | CZ20022125A3 (no) |
| DE (1) | DE60025650D1 (no) |
| EE (1) | EE200200206A (no) |
| GB (1) | GB9930318D0 (no) |
| HU (1) | HUP0204135A3 (no) |
| IL (1) | IL149871A0 (no) |
| IS (1) | IS6358A (no) |
| MX (1) | MXPA02005981A (no) |
| MY (1) | MY133606A (no) |
| NO (1) | NO20022924D0 (no) |
| NZ (1) | NZ518341A (no) |
| PL (1) | PL355887A1 (no) |
| RU (1) | RU2259997C2 (no) |
| SK (1) | SK8642002A3 (no) |
| WO (1) | WO2001046137A1 (no) |
| ZA (1) | ZA200202694B (no) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005117864A1 (en) * | 2004-05-28 | 2005-12-15 | Astrazeneca Ab | Combination product comprising anastrozole and a dual prenyl transferase inhibitor |
| WO2006038719A1 (ja) * | 2004-10-08 | 2006-04-13 | Kotobuki Pharmaceutical Co., Ltd. | ホスホン酸誘導体及び血中の高リン酸が関与する疾患の治療剤 |
| WO2007092285A2 (en) * | 2006-02-02 | 2007-08-16 | Link Medicine Corporation | Treatment of synucleinopathies |
| US8232402B2 (en) | 2008-03-12 | 2012-07-31 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
| CN102369202A (zh) | 2008-11-13 | 2012-03-07 | 链接医药公司 | 氮杂喹啉酮衍生物及其应用 |
| JP2012520884A (ja) | 2009-03-18 | 2012-09-10 | ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニバーシティー | フラビウイルス科ウイルス感染症を治療する方法および組成物 |
| WO2011088126A2 (en) * | 2010-01-13 | 2011-07-21 | Eiger Biopharmaceuticals, Inc. | Treatment of viral infection with prenyltransferase inhibitors |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1283906C (en) | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
| JPS60233076A (ja) | 1984-05-03 | 1985-11-19 | Sumitomo Chem Co Ltd | 新規なβ−ラクタム化合物およびその製造法 |
| DE3579888D1 (de) | 1984-11-08 | 1990-10-31 | Sumitomo Pharma | Carbapenemverbindungen und deren herstellung. |
| KR880006244A (ko) | 1986-11-24 | 1988-07-22 | 후지사와 도모 기찌 로 | 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법 |
| GB8921635D0 (en) | 1989-09-25 | 1989-11-08 | Fujisawa Pharmaceutical Co | 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives |
| CA2036163C (en) | 1990-02-14 | 2001-06-19 | Makoto Sunagawa | Novel beta-lactam compounds and their production |
| NZ237191A (en) | 1990-02-23 | 1992-12-23 | Sankyo Co | 2-((substituted amide) substituted heterocyclylthio) carbpen-2-em derivatives and pharmaceutical compositions |
| GB9107363D0 (en) | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
| US6083917A (en) | 1990-04-18 | 2000-07-04 | Board Of Regents, The University Of Texas System | Methods and compositions for the identification, characterization and inhibition of farnesyltransferase |
| US5185248A (en) * | 1990-05-08 | 1993-02-09 | E. R. Squibb & Sons, Inc. | Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation |
| JPH0578360A (ja) | 1991-01-31 | 1993-03-30 | Banyu Pharmaceut Co Ltd | ２−［２−（スルフアモイルアルキル）ピロリジニルチオカルバペネム誘導体 |
| GB9107342D0 (en) | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
| GB9107341D0 (en) | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
| FI101226B (fi) | 1991-06-04 | 1998-05-15 | Sankyo Co | Menetelmä lääkeaineena käyttökelpoisten 2-£2-(karbonyyli)pyrrolidin-4- yylitio|-6-(1-hydroksietyyli)-1-metyylikarbapen-2-eemi-3-karboksyyliha ppojohdannaisten valmistamiseksi |
| JPH04368386A (ja) | 1991-06-18 | 1992-12-21 | Sankyo Co Ltd | １−メチルカルバペネム−３−カルボン酸の製造法 |
| US5360798A (en) | 1991-07-04 | 1994-11-01 | Shionogi Seiyaku Kabushiki Kaisha | Aminooxypyrrolidinylthiocarbapenem compounds |
| EP0537007B1 (en) | 1991-10-11 | 1995-08-09 | E.R. SQUIBB & SONS, INC. | Use of formesyl-protein transferase inhibitors for the manufacture of a medicament for blocking neoplastic transformation of cells induced by ras oncogenes |
| JPH05239058A (ja) | 1991-12-17 | 1993-09-17 | Fujisawa Pharmaceut Co Ltd | ３−ピロリジニルチオ−１−アザビシクロ［３．２．０ヘプト−２−エン−２−カルボン酸化合物 |
| GB9202298D0 (en) | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
| FI103046B1 (fi) | 1992-03-11 | 1999-04-15 | Sankyo Co | Menetelmä lääkeaineina käyttökelpoisten pyrrolidinyylitiokarbapeneemijohdannaisten valmistamiseksi |
| CA2091309A1 (en) | 1992-03-26 | 1993-09-27 | Frederic H. Jung | Antibiotic compounds |
| GB9304156D0 (en) | 1992-03-26 | 1993-04-21 | Zeneca Ltd | Antibiotic compounds |
| EP0636133A1 (en) | 1992-04-13 | 1995-02-01 | Fujisawa Pharmaceutical Co., Ltd. | Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents |
| EP0581501B1 (en) | 1992-07-21 | 1998-09-09 | Zeneca Limited | Antibiotic carbapenem compounds |
| EP0581502B1 (en) | 1992-07-21 | 1998-10-21 | Zeneca Limited | Antibiotic carbapenem compounds |
| CA2099818A1 (en) | 1992-07-21 | 1994-01-22 | Frederic H. Jung | Antibiotic compounds |
| EP0590885B1 (en) | 1992-09-28 | 2000-03-15 | Zeneca Limited | Antibiotic carbapenem compounds |
| CA2106330A1 (en) | 1992-10-07 | 1994-04-08 | Patrice J. Siret | Antibiotic compounds |
| CA2118985A1 (en) | 1993-04-02 | 1994-10-03 | Dinesh V. Patel | Heterocyclic inhibitors of farnesyl protein transferase |
| JPH09500109A (ja) | 1993-06-18 | 1997-01-07 | メルク エンド カンパニー インコーポレーテッド | ファルネシル蛋白質トランスフェラーゼの阻害剤 |
| JP2534823B2 (ja) | 1993-07-07 | 1996-09-18 | 日本電気株式会社 | 印刷装置 |
| CA2172125A1 (en) | 1993-09-30 | 1995-04-06 | S. Jane Desolms | Inhibitors of farnesyl-protein transferase |
| US5468733A (en) | 1993-09-30 | 1995-11-21 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| CA2155448A1 (en) | 1994-08-11 | 1996-02-12 | Katerina Leftheris | Inhibitors of farnesyl protein transferase |
| US5571835A (en) | 1994-09-29 | 1996-11-05 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| CA2216564A1 (en) | 1995-03-29 | 1996-10-03 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| TR199800157T1 (xx) | 1995-07-31 | 1998-06-22 | Shionogi & Co.,Ltd. | Fosfolipaz A2 inhibit�r� aktivitesi olan pirolidin t�revleri. |
| GB9515975D0 (en) * | 1995-08-04 | 1995-10-04 | Zeneca Ltd | Chemical compounds |
| JPH1050029A (ja) | 1996-05-28 | 1998-02-20 | Nobuyuki Higuchi | 情報記憶装置 |
| AU4020897A (en) * | 1996-08-17 | 1998-03-06 | Zeneca Limited | 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors |
| AU5772698A (en) * | 1997-01-29 | 1998-08-18 | Zeneca Limited | Inhibitors of farnesyl protein transferase |
| AU7473398A (en) | 1997-05-07 | 1998-11-27 | University Of Pittsburgh | Inhibitors of protein isoprenyl transferases |
| JP2002503650A (ja) | 1998-02-10 | 2002-02-05 | アストラゼネカ ユーケー リミテッド | ファルネシルトランスフェラーゼ阻害剤 |
-
1999
- 1999-12-22 GB GBGB9930318.2A patent/GB9930318D0/en not_active Ceased
-
2000
- 2000-12-18 IL IL14987100A patent/IL149871A0/xx unknown
- 2000-12-18 KR KR1020027008034A patent/KR20020063251A/ko not_active Application Discontinuation
- 2000-12-18 AU AU22013/01A patent/AU776003B2/en not_active Ceased
- 2000-12-18 DE DE60025650T patent/DE60025650D1/de not_active Expired - Lifetime
- 2000-12-18 BR BR0016669-3A patent/BR0016669A/pt not_active IP Right Cessation
- 2000-12-18 RU RU2002119405/04A patent/RU2259997C2/ru not_active IP Right Cessation
- 2000-12-18 EE EEP200200206A patent/EE200200206A/xx unknown
- 2000-12-18 HU HU0204135A patent/HUP0204135A3/hu unknown
- 2000-12-18 AT AT00985605T patent/ATE316074T1/de not_active IP Right Cessation
- 2000-12-18 NZ NZ518341A patent/NZ518341A/xx unknown
- 2000-12-18 JP JP2001547048A patent/JP3742593B2/ja not_active Expired - Fee Related
- 2000-12-18 WO PCT/GB2000/004856 patent/WO2001046137A1/en active IP Right Grant
- 2000-12-18 CA CA002387579A patent/CA2387579A1/en not_active Abandoned
- 2000-12-18 SK SK864-2002A patent/SK8642002A3/sk unknown
- 2000-12-18 CN CNA2005100563322A patent/CN1680313A/zh active Pending
- 2000-12-18 PL PL00355887A patent/PL355887A1/xx not_active Application Discontinuation
- 2000-12-18 US US10/110,690 patent/US7101897B2/en not_active Expired - Fee Related
- 2000-12-18 MX MXPA02005981A patent/MXPA02005981A/es unknown
- 2000-12-18 CN CNB008174202A patent/CN1229344C/zh not_active Expired - Fee Related
- 2000-12-18 CZ CZ20022125A patent/CZ20022125A3/cs unknown
- 2000-12-18 EP EP00985605A patent/EP1255733B1/en not_active Expired - Lifetime
- 2000-12-20 MY MYPI20006011A patent/MY133606A/en unknown
- 2000-12-21 AR ARP000106845A patent/AR029460A1/es not_active Application Discontinuation
- 2000-12-22 CO CO00097282A patent/CO5360641A1/es not_active Application Discontinuation
-
2002
- 2002-04-05 ZA ZA200202694A patent/ZA200202694B/en unknown
- 2002-04-23 IS IS6358A patent/IS6358A/is unknown
- 2002-06-18 NO NO20022924A patent/NO20022924D0/no unknown
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