ZA200100473B - Bioenhanced formulations comprising eprosartan in oral solid dosage form. - Google Patents
Bioenhanced formulations comprising eprosartan in oral solid dosage form. Download PDFInfo
- Publication number
- ZA200100473B ZA200100473B ZA200100473A ZA200100473A ZA200100473B ZA 200100473 B ZA200100473 B ZA 200100473B ZA 200100473 A ZA200100473 A ZA 200100473A ZA 200100473 A ZA200100473 A ZA 200100473A ZA 200100473 B ZA200100473 B ZA 200100473B
- Authority
- ZA
- South Africa
- Prior art keywords
- eprosartan
- compound
- pharmaceutical composition
- pharmaceutically active
- inhibitor
- Prior art date
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- 239000002080 C09CA02 - Eprosartan Substances 0.000 title claims description 47
- OROAFUQRIXKEMV-LDADJPATSA-N eprosartan Chemical compound C=1C=C(C(O)=O)C=CC=1CN1C(CCCC)=NC=C1\C=C(C(O)=O)/CC1=CC=CS1 OROAFUQRIXKEMV-LDADJPATSA-N 0.000 title claims description 47
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- DJSLTDBPKHORNY-XMMWENQYSA-N eprosartan methanesulfonate Chemical compound CS(O)(=O)=O.C=1C=C(C(O)=O)C=CC=1CN1C(CCCC)=NC=C1\C=C(C(O)=O)/CC1=CC=CS1 DJSLTDBPKHORNY-XMMWENQYSA-N 0.000 claims description 22
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Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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- A—HUMAN NECESSITIES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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- A—HUMAN NECESSITIES
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US9341898P | 1998-07-20 | 1998-07-20 |
Publications (1)
Publication Number | Publication Date |
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ZA200100473B true ZA200100473B (en) | 2002-09-23 |
Family
ID=22238820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ZA200100473A ZA200100473B (en) | 1998-07-20 | 2001-01-17 | Bioenhanced formulations comprising eprosartan in oral solid dosage form. |
Country Status (16)
Country | Link |
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US (1) | US6517871B1 (no) |
EP (1) | EP1098634A4 (no) |
JP (1) | JP4575594B2 (no) |
KR (1) | KR100634953B1 (no) |
CN (1) | CN1198591C (no) |
AU (1) | AU763309B2 (no) |
BR (1) | BR9912145A (no) |
CA (1) | CA2338256C (no) |
HU (1) | HUP0103000A3 (no) |
IL (2) | IL140905A0 (no) |
NO (1) | NO321117B1 (no) |
NZ (1) | NZ509378A (no) |
PL (1) | PL193673B1 (no) |
TR (1) | TR200100172T2 (no) |
WO (1) | WO2000004862A2 (no) |
ZA (1) | ZA200100473B (no) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
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US8168616B1 (en) | 2000-11-17 | 2012-05-01 | Novartis Ag | Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension |
US20020168393A1 (en) * | 2001-05-08 | 2002-11-14 | Ryota Sugimoto | Implantable medical material and implantable medical device |
CN101404892B (zh) | 2002-05-14 | 2012-04-04 | Fmc有限公司 | 微晶纤维素组合物 |
DE10230272A1 (de) * | 2002-07-05 | 2004-01-22 | Solvay Pharmaceuticals Gmbh | AT1-Rezeptorantagonisten zur Prävention von Folgeschlaganfällen |
WO2004039352A2 (en) * | 2002-10-31 | 2004-05-13 | Ranbaxy Laboratories Limited | Amorphous form of losartan potassium |
US20060210620A1 (en) * | 2003-01-21 | 2006-09-21 | Kumra Pannanchukunnath M | Co-precipitated amorphous losartan and dosage forms comprising the same |
US20040198789A1 (en) * | 2003-02-28 | 2004-10-07 | Recordati Ireland Limited | Lercanidipine/ARB/diuretic therapeutic combinations |
US20050220881A1 (en) * | 2003-10-10 | 2005-10-06 | Bvm Holding Co. | Pharmaceutical composition |
EP2361620B1 (en) | 2004-02-06 | 2016-04-06 | PHARMATEL (R&D) PTY LIMITED as Trustee for the PHARMATEL (R & D) TRUST | Use of aminosalicylates in diarrhoea-predominant irritable bowel syndrome |
ES2277199T3 (es) * | 2004-04-15 | 2007-07-01 | Helm Ag | Procedimiento para la preparacion de adsorbatos de valsartan pulverulentos de flujo libre. |
DE602005022175D1 (de) * | 2004-05-28 | 2010-08-19 | Salix Pharmaceuticals Inc | Prävention, behandlung und linderung strahlungsinduzierter enteritis |
US20060099230A1 (en) * | 2004-11-10 | 2006-05-11 | Chin-Chih Chiang | Novel formulations of eprosartan with enhanced bioavailability |
US20060160871A1 (en) * | 2004-12-07 | 2006-07-20 | Nektar Therapeutics | Stable non-crystalline formulation comprising losartan |
US7452872B2 (en) | 2005-08-24 | 2008-11-18 | Salix Pharmaceuticals, Inc. | Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives |
US8921344B2 (en) * | 2006-11-03 | 2014-12-30 | Salix Pharmaceuticals, Inc. | Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives |
BRPI0615195A8 (pt) * | 2005-08-24 | 2018-03-06 | Salix Pharmaceuticals Inc | preparação farmacêutica, embalagem, e, métodos para tratar doença gastrintestinal, para fabricar uma cápsula e para testar dissolução de cápsulas de balsalazida. |
US7879382B2 (en) * | 2005-09-30 | 2011-02-01 | Fmc Corporation | Stabilizers and compositions and products comprising same |
US20080014263A1 (en) * | 2006-07-17 | 2008-01-17 | Glenmark Pharmaceuticals Limited | Amorphous eprosartan mesylate and process for the preparation thereof |
CN101528224A (zh) * | 2006-09-05 | 2009-09-09 | 阿斯利康(瑞典)有限公司 | 包含坎地沙坦西酯的药用组合物 |
WO2008057266A2 (en) | 2006-10-27 | 2008-05-15 | Fmc Corporation | Dry granulation binders, products, and use thereof |
ES2359377T3 (es) * | 2006-10-27 | 2011-05-23 | Fmc Corporation | Celulosa microcristalina coprocesada y alcohol de azúcar como excipiente para formulaciones de comprimidos. |
EP2295431A3 (en) * | 2007-07-25 | 2011-08-03 | Hetero Drugs Limited | Substantially pure eprosartan free base |
WO2009013760A2 (en) * | 2007-07-25 | 2009-01-29 | Hetero Drugs Limited | Eprosartan mesylate crystalline particles and a process for preparing pure eprosartan |
EP2153822A1 (en) * | 2008-08-13 | 2010-02-17 | Lek Pharmaceuticals D.D. | Granulation of active pharmaceutical ingredients |
EP2293781A1 (en) * | 2008-04-09 | 2011-03-16 | LEK Pharmaceuticals d.d. | Granulation of active pharmaceutical ingredients |
AR072477A1 (es) * | 2008-07-11 | 2010-09-01 | Solvay Pharm Bv | Formulacion farmaceutica de eprosartan. uso. |
JP2011136908A (ja) * | 2009-12-25 | 2011-07-14 | Kyowa Yakuhin Kogyo Kk | アンギオテンシンii受容体拮抗剤を含む固形製剤および固形製剤におけるアンギオテンシンii受容体拮抗剤の保存安定性向上方法 |
EP2545044A1 (en) * | 2010-03-08 | 2013-01-16 | ratiopharm GmbH | Dabigatran etexilate-containing pharmaceutical composition |
WO2013052118A1 (en) | 2011-10-05 | 2013-04-11 | Fmc Corporation | Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses |
EP2764046B1 (en) | 2011-10-05 | 2021-04-21 | DuPont Nutrition USA, Inc. | Stabilizer composition of microcrystalline cellulose and carboxymethylcellulose, method for making, and uses |
BR112014013792B8 (pt) | 2011-12-09 | 2020-11-10 | Dupont Nutrition Usa Inc | composição estabilizadora co-atritada compreendendo carboximetilcelulose de alto grau de substituição e baixa viscosidade, alimento, composição industrial, e, método para fazer a composição estabilizadora |
JO3339B1 (ar) * | 2012-09-11 | 2019-03-13 | Shanghai Inst Pharmaceutical Ind | شكل مستقر غير متبلور من الأغوميلاتين وعملية تحضيره والتركيبات الدوائية التي تحتوي عليه |
EP3380079A4 (en) * | 2015-11-25 | 2019-08-21 | Patheon Development Services Inc. | AMORPHOUS DISPERSION GRANULES AND PHARMACEUTICAL FORMS FOR ORAL USE |
CN107456445A (zh) * | 2016-06-06 | 2017-12-12 | 南京卡文迪许生物工程技术有限公司 | 依普利酮口服固体制剂及其制备方法 |
KR20200043618A (ko) * | 2018-10-18 | 2020-04-28 | 주식회사유한양행 | 아미노피리미딘 유도체 또는 이의 염을 포함하는 경구투여용 약학 조성물 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2525108B1 (fr) * | 1982-04-19 | 1989-05-12 | Elan Corp Ltd | Medicaments a haut degre de solubilite et procede pour leur obtention |
US5185351A (en) * | 1989-06-14 | 1993-02-09 | Smithkline Beecham Corporation | Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists |
ATE177634T1 (de) * | 1990-12-14 | 1999-04-15 | Smithkline Beecham Corp | Angiotensin-ii-rezeptor blockierende zusammensetzungen |
TW442301B (en) * | 1995-06-07 | 2001-06-23 | Sanofi Synthelabo | Pharmaceutical compositions containing irbesartan |
FR2746013B1 (fr) | 1996-03-18 | 1998-05-29 | Sanofi Sa | Utilisation de composes antiarythmiques dans la prevention de la mortalite post infarctus |
BR9708336A (pt) * | 1996-03-29 | 1999-08-03 | Smithkline Beecham Corp | Diidrato de eprosartan e processo para sua produção e formulação |
US5795909A (en) * | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
AR011126A1 (es) * | 1997-02-14 | 2000-08-02 | Smithkline Beecham Corp | Procedimiento para preparar eprosartano y compuestos intermediarios. |
DE19741635A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
HUP0004407A3 (en) * | 1997-11-17 | 2002-03-28 | Smithkline Beecham Corp | Immediate and modified release oral dosage formulations containing eprosartan and processes for their manufacture |
US6558699B2 (en) * | 1997-11-17 | 2003-05-06 | Smithkline Beecham Corporation | High drug load immediate and modified release oral dosage formulations and processes for their manufacture |
ZA991922B (en) * | 1998-03-11 | 1999-09-13 | Smithkline Beecham Corp | Novel compositions of eprosartan. |
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1999
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- 1999-07-20 WO PCT/US1999/012396 patent/WO2000004862A2/en active IP Right Grant
- 1999-07-20 PL PL99346863A patent/PL193673B1/pl not_active IP Right Cessation
- 1999-07-20 BR BR9912145-0A patent/BR9912145A/pt not_active Application Discontinuation
- 1999-07-20 HU HU0103000A patent/HUP0103000A3/hu not_active Application Discontinuation
- 1999-07-20 IL IL14090599A patent/IL140905A0/xx unknown
- 1999-07-20 CN CNB998103861A patent/CN1198591C/zh not_active Expired - Fee Related
- 1999-07-20 TR TR2001/00172T patent/TR200100172T2/xx unknown
- 1999-07-20 KR KR1020017000833A patent/KR100634953B1/ko not_active IP Right Cessation
- 1999-07-20 US US09/743,946 patent/US6517871B1/en not_active Expired - Fee Related
- 1999-07-20 CA CA002338256A patent/CA2338256C/en not_active Expired - Fee Related
- 1999-07-20 JP JP2000560855A patent/JP4575594B2/ja not_active Expired - Fee Related
- 1999-07-20 EP EP99935300A patent/EP1098634A4/en not_active Withdrawn
- 1999-07-20 NZ NZ509378A patent/NZ509378A/xx not_active IP Right Cessation
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- 2001-01-17 ZA ZA200100473A patent/ZA200100473B/en unknown
- 2001-01-17 NO NO20010283A patent/NO321117B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
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EP1098634A4 (en) | 2006-10-25 |
TR200100172T2 (tr) | 2001-05-21 |
PL346863A1 (en) | 2002-03-11 |
IL140905A0 (en) | 2002-02-10 |
KR20010071990A (ko) | 2001-07-31 |
BR9912145A (pt) | 2001-09-25 |
WO2000004862A2 (en) | 2000-02-03 |
CA2338256C (en) | 2008-09-23 |
NO20010283D0 (no) | 2001-01-17 |
PL193673B1 (pl) | 2007-03-30 |
IL140905A (en) | 2013-06-27 |
AU5080799A (en) | 2000-02-14 |
HUP0103000A2 (hu) | 2002-05-29 |
JP4575594B2 (ja) | 2010-11-04 |
NO321117B1 (no) | 2006-03-20 |
EP1098634A2 (en) | 2001-05-16 |
NZ509378A (en) | 2003-04-29 |
CN1198591C (zh) | 2005-04-27 |
HUP0103000A3 (en) | 2002-08-28 |
WO2000004862A3 (en) | 2000-05-04 |
CN1315853A (zh) | 2001-10-03 |
US6517871B1 (en) | 2003-02-11 |
AU763309B2 (en) | 2003-07-17 |
KR100634953B1 (ko) | 2006-10-17 |
NO20010283L (no) | 2001-01-19 |
JP2002521315A (ja) | 2002-07-16 |
CA2338256A1 (en) | 2000-02-03 |
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