YU48685B - Aldehidni postupak za dobijanje sumpornih derivata imidazola i novi intermedijeri - Google Patents
Aldehidni postupak za dobijanje sumpornih derivata imidazola i novi intermedijeriInfo
- Publication number
- YU48685B YU48685B YU82393A YU82393A YU48685B YU 48685 B YU48685 B YU 48685B YU 82393 A YU82393 A YU 82393A YU 82393 A YU82393 A YU 82393A YU 48685 B YU48685 B YU 48685B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- radicals
- optionally substituted
- radical
- alkyl
- carbon atoms
- Prior art date
Links
- 150000002460 imidazoles Chemical class 0.000 title 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 8
- -1 mercapto, formyl Chemical group 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004434 sulfur atom Chemical group 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- RLYNUCZWGJPITA-UHFFFAOYSA-N [S].C1=CNC=N1 Chemical class [S].C1=CNC=N1 RLYNUCZWGJPITA-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002720 diazolyl group Chemical group 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/58—Derivatives of thiocarboxylic acids, the doubly-bound oxygen atoms being replaced by nitrogen atoms, e.g. imino-thio ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Epoxy Resins (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Abstract
Aldehidni postupak za dobijanje sumpornih derivata imidazola opste formule (I): gde R1 je alkil, alkenil, alkinil ili alkiltio radikal, normalan ili racvast koji obuhvata do 10 atoma ugljenika, ili cikloalkil radikal eventualno supstituisan koji obuhvata 3-7 atoma ugljenika; R2 i R3 identican ili razliciti se biraju izmedu: a) atoma vodonika ili halogena, hidroksil, merkapto, formil, acil ili karboksi radikala slobodnog, salifikovanog ili esterifikovanog nitro ili cijano i -PO3(R)2 gde R predstavlja atom vodonika ili alkil ili fenil radikal eventualno supstituisan, b) radikala -(CH2)m1-S(O)m2-X-R10 gde m1 predstavlja broj izmedu 0 i 4, m2 predstavlja broj izmedu 0 i 2 i X predstavlja prostu vezu ili radikale -NH-, -NH-CO-, -NH-CO-O-, -N=CH-N-R13, -NH-CO-NH- i R10 I R13 identicni ili razliciti predstavljaju atom vodonika, alkil ili alkenil radikal normalan ili racvast koji obuhvata do 6 atoma ugljenika, cikloalkil koji obuhvata 3-6 atoma ugljenika, fenil ili benzil eventualno supstituisane ili radikale piridil, nitropiridil, pirimidil, tetrazolil, diazolil, piperidinil, alkil piperidinil, tiazolil, alkiltiazolil, tetrahidrofuranil, metiletetrahidrofuranil; c) radikala alkil, alkenil, alkoksi ili alkiltio gde je atom sumpora eventualno mono ili dioksidovan, normalnih ili racvastih koji sadrze do 6 atoma ugljenika eventualno prekinutih sa 1 ili vise heteroatoma odabranih izmedu atoma sumpora, kiseonika i azota i eventualno supstituisanih; d) radikala fenil, benzoil i feniltio gde je atom sumpora eventualno mono ili dioksidovan, i eventualno supstituisanih; e) radikala gde R6 i R7 ili R8 i R9 identicni ili razliciti se biraju izmedu: - atoma vodonika, - amino kiselina - radikala alkil i alkenil koji sadrze do 6 atoma ugljenika, eventualno supstituisanih; - radikala fenil, benzil i fenetil, eventualno supstituisanih; - radikala -(CH2)m1-S(O)m2-X-R10 takvog kao sto je definisano napred ili R6 i R7 ili R8 i R9 grade, respektivno, sa atomom azota na koji su vezani mono ciklicni radikal koji obuhvata 5, 6 ili 7 clanova ili radikal sastavljen od kondenzovanih prstena identicnih ili razlicitih koji obuhvata 8 do 14 clanova i koji eventualno obuhvataju 1 ili vise heteroatoma odabranih izmedu atoma kiseonika, azota i sumpora i eventualno supstituisanih sa jednim ili vise supstituenata odabranih izmedu atoma halogena i radikala hidroksi, nitro, alkil i alkoksi koji obuhvataju do 6 atoma ugljenika, amino eventualno supstituisana sa jednim ili dva alkil radikala identicna ili razlicita koji obuhvataju do 6 atoma ugljenika i fenil; ili R8 i R9 identicni ili razliciti predstavljaju acil radikal ili R8 i R9 predstavljaju radikal karbamoil, alkoksikarbonil ili benziloksikarbonil, ili R8 i R9 grade zajedno sa atomom azota na koji su vezani radikal ftalimido ili sukcinamido, f) radikala -S-S-R12 gde R12 ima znacenja data sa R2 i R3 u tackama a) do e) sa izuzetkom radikala amino i alkoksi, gde bar jedan od radikala R2 i R3 predstavlja radikal alkoksi eventualno supstit
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9312413A FR2711367B1 (fr) | 1993-10-19 | 1993-10-19 | Nouveau procédé de préparation de dérivés soufrés de l'imidazole et les nouveaux intermédiaires obtenus. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU82393A YU82393A (sh) | 1996-07-24 |
| YU48685B true YU48685B (sh) | 1999-06-15 |
Family
ID=9451963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU82393A YU48685B (sh) | 1993-10-19 | 1993-12-29 | Aldehidni postupak za dobijanje sumpornih derivata imidazola i novi intermedijeri |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5527919A (sh) |
| EP (1) | EP0648763B1 (sh) |
| JP (1) | JP3723585B2 (sh) |
| KR (1) | KR950011414A (sh) |
| CN (1) | CN1097419A (sh) |
| AT (1) | ATE201022T1 (sh) |
| AU (1) | AU676221B2 (sh) |
| BR (1) | BR9400015A (sh) |
| CA (1) | CA2112871A1 (sh) |
| CZ (1) | CZ1194A3 (sh) |
| DE (1) | DE69427179T2 (sh) |
| DK (1) | DK0648763T3 (sh) |
| ES (1) | ES2157962T3 (sh) |
| FI (1) | FI940030A (sh) |
| FR (1) | FR2711367B1 (sh) |
| GR (1) | GR3036053T3 (sh) |
| HR (1) | HRP940005A2 (sh) |
| HU (1) | HUT67915A (sh) |
| IL (1) | IL108200A0 (sh) |
| NO (1) | NO940019L (sh) |
| NZ (1) | NZ250601A (sh) |
| PL (1) | PL301776A1 (sh) |
| PT (1) | PT648763E (sh) |
| RU (1) | RU2135475C1 (sh) |
| SI (1) | SI9400018A (sh) |
| SK (1) | SK494A3 (sh) |
| YU (1) | YU48685B (sh) |
| ZA (1) | ZA9420B (sh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2716882B1 (fr) * | 1994-03-04 | 1996-04-05 | Roussel Uclaf | Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques. |
| WO1997030036A1 (en) * | 1996-02-15 | 1997-08-21 | Novartis Ag | Aryl derivatives |
| US6063930A (en) * | 1996-04-03 | 2000-05-16 | Merck & Co., Inc. | Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors |
| US6080870A (en) * | 1996-04-03 | 2000-06-27 | Merck & Co., Inc. | Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors |
| EP0855392A3 (de) | 1997-01-22 | 2000-01-05 | Hoechst Aktiengesellschaft | Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| AU4844699A (en) * | 1998-07-01 | 2000-01-24 | Merck & Co., Inc. | Process for making 1,5-disubstituted imidazoles |
| DE19832428A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19832429A1 (de) | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| JP5395905B2 (ja) * | 2008-09-02 | 2014-01-22 | エルダー・ファーマシューティカルズ・リミテッド | 抗炎症化合物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATA937274A (de) * | 1973-12-17 | 1978-02-15 | Thomae Gmbh Dr K | Verfahren zur herstellung neuer araliphatischer ketone |
| IL97219A (en) * | 1990-02-19 | 1995-12-08 | Ciba Geigy Ag | Elliptical amino compounds converted by biphenyl process for their preparation and pharmaceutical preparations containing them |
| IE910913A1 (en) * | 1990-03-20 | 1991-09-25 | Sanofi Sa | N-substituted heterocyclic derivates, their preparation¹and pharmaceutical compositions containing them |
| IL98319A (en) * | 1990-07-05 | 1997-04-15 | Roussel Uclaf | Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them |
| CA2058198A1 (en) * | 1991-01-04 | 1992-07-05 | Adalbert Wagner | Azole derivatives, process for their preparation, and their use |
| IE920175A1 (en) * | 1991-02-11 | 1992-08-12 | Zeneca Ltd | Nitrogen heterocycles |
| TW209213B (sh) * | 1991-08-21 | 1993-07-11 | Yamanouchi Pharma Co Ltd | |
| EP0550313A1 (fr) * | 1991-12-30 | 1993-07-07 | Synthelabo | Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse |
-
1993
- 1993-10-19 FR FR9312413A patent/FR2711367B1/fr not_active Expired - Fee Related
- 1993-12-23 NZ NZ250601A patent/NZ250601A/en unknown
- 1993-12-27 IL IL10820093A patent/IL108200A0/xx unknown
- 1993-12-29 JP JP35413293A patent/JP3723585B2/ja not_active Expired - Fee Related
- 1993-12-29 YU YU82393A patent/YU48685B/sh unknown
- 1993-12-30 RU RU93057747A patent/RU2135475C1/ru active
-
1994
- 1994-01-03 HR HR9312413A patent/HRP940005A2/xx not_active Application Discontinuation
- 1994-01-04 DK DK94400008T patent/DK0648763T3/da active
- 1994-01-04 CZ CZ9411A patent/CZ1194A3/cs unknown
- 1994-01-04 US US08/177,153 patent/US5527919A/en not_active Expired - Lifetime
- 1994-01-04 KR KR1019940000059A patent/KR950011414A/ko not_active Application Discontinuation
- 1994-01-04 HU HU9400017A patent/HUT67915A/hu unknown
- 1994-01-04 ZA ZA9420A patent/ZA9420B/xx unknown
- 1994-01-04 BR BR9400015A patent/BR9400015A/pt not_active Application Discontinuation
- 1994-01-04 DE DE69427179T patent/DE69427179T2/de not_active Expired - Fee Related
- 1994-01-04 ES ES94400008T patent/ES2157962T3/es not_active Expired - Lifetime
- 1994-01-04 EP EP94400008A patent/EP0648763B1/fr not_active Expired - Lifetime
- 1994-01-04 AU AU53004/94A patent/AU676221B2/en not_active Ceased
- 1994-01-04 FI FI940030A patent/FI940030A/fi unknown
- 1994-01-04 NO NO940019A patent/NO940019L/no unknown
- 1994-01-04 CN CN94100188A patent/CN1097419A/zh active Pending
- 1994-01-04 PL PL94301776A patent/PL301776A1/xx unknown
- 1994-01-04 AT AT94400008T patent/ATE201022T1/de not_active IP Right Cessation
- 1994-01-04 SK SK4-94A patent/SK494A3/sk unknown
- 1994-01-04 PT PT94400008T patent/PT648763E/pt unknown
- 1994-01-05 CA CA002112871A patent/CA2112871A1/fr not_active Abandoned
- 1994-01-18 SI SI9400018A patent/SI9400018A/sl unknown
-
2001
- 2001-06-14 GR GR20010400895T patent/GR3036053T3/el not_active IP Right Cessation
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