WO2025214913A1

WO2025214913A1 - Closed loop resuscitation systems and methods

Info

Publication number: WO2025214913A1
Application number: PCT/EP2025/059352
Authority: WO
Inventors: Joseph Ernest ROCK
Original assignee: Koninklijke Philips NV
Current assignee: Koninklijke Philips NV
Priority date: 2024-04-10
Filing date: 2025-04-04
Publication date: 2025-10-16
Anticipated expiration: 2026-10-10

Abstract

A closed loop resuscitation system (10) employing two or more of a chest compressor (20) operable to perform the artificial circulation of blood of the patient, an electrical therapeutic device (21) operable to perform the shock therapy of the patient, a ventilator (22) operable to perform the ventilation therapy of the patient, and an infusion pump (23) operable to perform an infusion delivery of the patient. The closed loop resuscitation system (10) further employs a resuscitation coordinator (40) configured to coordinate, in accordance with a resuscitation procedure, two or more of a performance of the artificial circulation of blood by the chest compressor (20), a performance of the shock therapy of the patient by the electrical therapeutic device (21), a performance of the ventilation therapy of the patient by the ventilator (22), and the performance of the infusion delivery of the patient by the infusion pump (23).

Description

CLOSED LOOP RESUSCITATION SYSTEMS AND METHODS

FIELD OF THE INVENTION

The present disclosure generally relates to a resuscitation of a patient. The present disclosure particularly related to a coordination of by the rescuer(s) and/or the device(s) during a resuscitation of a patient (e.g., cardiopulmonary resuscitation, basic life support and advanced life support).

BACKGROUND OF THE INVENTION

Cardiopulmonary resuscitation (CPR) is lifesaving intervention that is provided when a patient is in cardiac arrest (e.g., with no or ineffective mechanical activity of the patient’s heart) and primarily consists of chest compressions often combined with ventilation and the administration of medication. A quality of CPR is dependent on various factors including maintaining an adequate compression rate and compression depth and avoiding excessive ventilation.

Basic life support (BLS) is a level of medical care for a patient with life-threatening cardiac arrest, respiratory distress and/or an obstructed airway, and primarily consists of CPR and defibrillation as needed. A quality of BLS is dependent on various factors including a proper timing of any application of defibrillation to the patient during an application of CPR to the patient.

Advanced life support (ALS) may consist of BLS with an intravenous therapy of fluids and, medications delivered to the patient during CPR. A quality of ALS is dependent on various factors including a monitoring of the effects of the intravenous therapy on the application of the CPR to the patient.

SUMMARY OF THE INVENTION

The present disclosure is directed to a coordination of device(s) during a resuscitation of the patient, particularly based on real-time measurement(s)/assessment(s) of a manual performance and/or an automated performance of a resuscitation procedure (e.g., CPR, BLS or ALS) being applied on the patient by the device(s) and/or real-time measurement(s)/assessment(s) of a physiological state of the patient. The present disclosure may be embodied as (1) a closed loop resuscitation system, (2) a resuscitation commander as a component of closed loop resuscitation system, and (3) a closed loop resuscitation method.

Various exemplary embodiments of a closed loop resuscitation system of the present disclosure employ two or more of (1) a chest compressor (e.g., sensory or mechanical) operable to perform the artificial circulation of the blood of the patient, (2) a defibrillator (e.g., automatic or semi-automatic defibrillator)operable to perform the shock therapy of the patient, (3) a ventilator (e.g., invasive or non-invasive) operable to perform the ventilation therapy of the patient and (4) an infusion pump operable to perform the infusion delivery of the patient. The various exemplary embodiments of the closed loop resuscitation system of the present disclosure further employs a resuscitation coordinator configured to coordinate, in accordance with a resuscitation procedure (e.g., CPR, BLS, or ALS), two or more of (1) a performance of the artificial circulation of the blood by the chest compressor, (2) a performance of the shock therapy of the patient by the defibrillator, (3) a performance of the ventilation therapy of the patient by the ventilator, and (4) a performance of the infusion delivery of the patient by the infusion pump.

The coordination by the resuscitation coordinator, in accordance with the resuscitation procedure, may be based on a physiological state of the patient corresponding to one or more of (1) the performance of the artificial circulation of the blood by the chest compressor, (2) the performance of shock therapy of the patient by the defibrillator, (3) the performance of the ventilation therapy of the patient by the ventilator, and (4) a performance of the infusion delivery of the patient by the infusion pump.

Various exemplary embodiments of a resuscitation coordinator employ a non-transitory machine-readable storage medium encoded with instructions for execution by one or more processors to coordinate, in accordance with a resuscitation procedure (e.g., CPR, BLS, or ALS), two or more (1) a performance of artificial circulation of the blood of the patient by a chest compressor (e.g., sensory or mechanical), (2) a performance of a shock therapy of the patient by a defibrillator (e.g., automatic or semi-automatic), (3) a performance of a ventilation therapy of the patient by a ventilator (e.g., invasive or non-invasive), and (4) a performance of the infusion delivery of the patient by the infusion pump. The non-transitory machine-readable storage medium may be encoded with instructions wherein the coordination by the resuscitation coordinator, in accordance with the resuscitation procedure, may be based on a physiological state of the patient corresponding to one or more of (1) the performance of the artificial circulation of the blood of the patient by the chest compressor, (2) the performance of shock therapy of the patient by the defibrillator, (3) the performance of the ventilation therapy of the patient by the ventilator, and (4) the performance of the infusion delivery of the patient by the infusion pump.

Various exemplary embodiments of a closed loop resuscitation method of the present disclosure involve a performance of two or more of (1) artificial circulation of the blood of the patient by a chest compressor (e.g., sensory or mechanical), (2) a shock therapy of the patient by a defibrillator (e.g., automatic or semi-automatic) and (3) a ventilation therapy of the patient by a ventilator (e.g., invasive or non-invasive). The various exemplary embodiments of the closed loop resuscitation method of the present disclosure further involves a coordination, by a resuscitation coordinator coordinating in accordance with a resuscitation procedure (e.g., CPR, BLS, or ALS), two or more of (1) the performance of the artificial circulation of the blood of the patient by the chest compressor, (2) the performance of the shock therapy of the patient by the defibrillator, (3) the performance of the ventilation therapy of the patient by the ventilator, and (4) a performance of the infusion delivery of the patient by the infusion pump.

The coordination by the resuscitation coordinator, in accordance with the resuscitation procedure, may be based on a physiological state of the patient corresponding to one or more of (1) the performance of the artificial circulation of the blood of the patient by the chest compressor, (2) the performance of shock therapy of the patient by the defibrillator and (3) the performance of the ventilation therapy of the patient by the ventilator.

The foregoing exemplary embodiments and other embodiments of the present disclosure as well as various structures and advantages of the present disclosure will become further apparent to those having ordinary skill in the art from the following detailed description of various embodiments of the present disclosure read in conjunction with the accompanying drawings. The detailed description and drawings are merely illustrative of the present disclosure rather than limiting, the scope of the present disclosure being defined by the appended claims and equivalents thereof. BRIEF DESCRIPTION OF THE DRAWINGS

The present disclosure will present in detail the following description of exemplary embodiments with reference to the following figures wherein:

FIG. 1 illustrates an exemplary embodiment of a closed loop resuscitation system in accordance with the present disclosure;

FIG. 2 illustrates a flowchart representative of an exemplary embodiment of a closed loop resuscitation method in accordance with the present disclosure;

FIG. 3 illustrates an exemplary execution of the flowchart of FIG. 2; and

FIG. 4 illustrates an exemplary embodiment of a resuscitation commander in accordance with the present disclosure.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

The present disclosure encompasses a coordinated execution of a resuscitation of a patient by devices, primarily including two or more of a chest compressor, an electrical therapy device (e.g., a defibrillator), a ventilator and an infusion pump (collectively hereinafter the “resuscitation devices”).

For purposes of describing and claiming the present disclosure, the term “resuscitation procedure” broadly encompasses any and all procedures, as known in the art of the present disclosure or hereinafter conceived, for operating the resuscitation devices to resuscitate a cardiovascular system and/or a respiratory system of a patient during and/or subsequent to heart failure, cardia arrest and/or respiratory failure of the patient.

Examples of a resuscitation procedure include, but are not limited to, a cardiopulmonary resuscitation (CPR), multi-system trauma, traumatic brain injury, sepsis. Each of these procedures can be performed at either the BLS or ALS level as dictated by the license level of the rescuer.

In practice of the present disclosure, a resuscitation procedure may be an executable in the form of one or more protocols, each protocol devised in compliance with established guideline(s). Examples of such guidelines include, but are not limited to, guidelines established by the American Heart Association, the American College of Surgeons, the Society of Critical Care Medicine. Also in practice of the present disclosure, a resuscitation procedure may be nonadaptive or adaptive to characteristics of the patient. Examples of such characteristics include, but are not limited to, an age, a race, a gender, an advanced directive of the patient, and/or a physiological state of the patient.

For purposes of describing and claiming the present disclosure, the terms “coordinate”, “coordinating” and “coordination” broadly encompasses (1) delineating and/or synchronizing operations of two or more of the resuscitation devices in accordance with a resuscitation procedure being applied to a patient, and/or (2) modifying and/or adjusting an operation of one or more of the resuscitation devices during a resuscitation procedure in accordance with a resuscitation procedure being applied to a patient.

Non-limiting examples of a coordinated delineation includes specifying protocol(s) and/or guideline(s) for two or more of the chest compressor, the defibrillator, the ventilator, the infusion pump.

Non-limiting examples of a coordinated synchronization include (1) operations of a chest compressor and a defibrillator may be synchronized to ensure a cardiac rhythm analysis of the patient by the defibrillator timely and properly occurs during pauses in operation by the chest compressor, (2) operations of a chest compressor and a ventilator may be synchronized to ensure an accurate timing of an inspiratory phase of the ventilation of the patient by the ventilator during pauses in operation by the chest compressor, (3) operations of a defibrillator and a ventilator may be synchronized to ensure a pulse may be measured by the defibrillator during pauses in operation by the ventilator, and (4) operations of an infusion pump and a ventilator may be synchronized to ensure proper delivery of a fluid or a medication to the patient.

Non-limiting examples of modifying/adjusting of operations include (1) modifying the tempo of the operations of the devices, (2) adjusting settings and/or parameters of devices including but not limited to increasing or decreasing a depth of compression by the chest compressor, increasing or decreasing a shocking level of the defibrillator, and increasing or decreasing a fraction of inspired oxygen by the ventilator, and (3) timing or modifying the infusion of medication from the infusion pump.

In practice, the coordinated execution of the resuscitation of the patient by devices may be implemented by a strict adherence to a particular resuscitation procedure, or by a processing of performance data associated with the execution of the resuscitation procedure and/or physiological data associated with the patient during the execution of the resuscitation procedure.

Examples of performance data include, but are not limited to, a tidal volume, an inspiration: expiration ratio, a compression depth, a respiratory rate, and a chest recoil distance of the patient.

Examples of physiological data include, but are not limited to, an oxygen saturation, end- tidal carbon dioxide, a heart rate, an electrocardiogram (ECG) morphology, and a blood pressure of the patient.

To facilitate an understanding of the present disclosure, the following description of FIG. 1 -4 teaches in accordance with the present disclosure for making and using various embodiments of the present disclosure. From the following description of FIGS. 1-4, those having ordinary skill in the art of the present disclosure will appreciate how to apply the present disclosure to make and use additional embodiments of the present disclosure.

Referring to FIG. 1, a closed-loop resuscitation system 10 of the present disclosure employs a chest compressor 20, an electrical therapeutic device 21, ventilator 22 and an infusion pump 23.

For purposes of describing and claiming the present disclosure, the term “chest compressor” broadly encompasses any and all devices, known or hereinafter conceived, for performing artificial circulation of the blood of a patient as known in the art of the present disclosure or hereinafter conceived. Examples of a chest compressor include, but are not limited to, a mechanical chest compressor, and a chest compression pad.

For purposes of describing and claiming the present disclosure, the term “electrical therapeutic device” broadly encompasses any and all devices for performing a shock therapy of a patient as known in the art of the present disclosure or hereinafter conceived. Examples of a defibrillator include, but are not limited to, an Automatic External Defibrillator, a Semi- Automatic External Defibrillator, and a Manual Defibrillator.

For purposes of describing and claiming the present disclosure, the term “ventilator” broadly encompasses any and all devices for performing a ventilation therapy of a patient as known in the art of the present disclosure or hereinafter conceived. Examples of a ventilator include, but are not limited to, Bilevel Positive Airway Pressure Machine and a Mechanical Ventilator.

For purposes of describing and claiming the present disclosure, the term “infusion pump” broadly encompasses any and all devices for performing an infusion delivery of a patient (e.g., infuse of fluid, medication and/or nutrients) as known in the art of the present disclosure or hereinafter conceived. Examples of an infusion pump include, but are not limited to, Gravity Infusion Pump, Syringe Infusion Pump, and a Volumetric Infusion Pump.

Still referring to FIG. 1, the closed-loop resuscitation system 10 of the present disclosure introduces a resuscitation coordinator 40 for coordinating a performance of two or more of a performance of artificial circulation of the blood of the patient by chest compressor 20, a performance of a shock therapy of the patient by electrical therapeutic device 21, a performance of a ventilation therapy of the patient by ventilator 22, and a performance of an infusion delivery of the patient by infusion pump 23.

To this end, a resuscitation commander 40 employs a compression commander 41a, a defibrillation commander 41b, a ventilation commander 41c and an infusion commander 41 d for communicating chest compressor 20, electrical therapeutic device 21, ventilator 22 and infusion pump 23, respectively.

In practice, each commander is a module embodied as hardware, software and firmware for implementing a communication technology, wired or wireless, as known in the art of the present disclosure or hereinafter conceived. Examples of a communication technology include, but are not limited to, a universal serial bus, Bluetooth, Wi-Fi and cellular.

In one exemplary embodiment, a commander may include an agent for communicating performance data (and any physiological data known by the commander) and for executing any coordination commands as will be further explained in the present disclosure.

Further in practice, a commander of the present disclosure may be external to or installed within a respective device. For example, compression commander 41a may be externally coupled to chest compressor 20 or installed within chest compressor 20 as an independent module or within a controller of chest compressor 20.

Still referring to FIG. 1, the closed-loop resuscitation system 10 of the present disclosure may further employs one or more physiological data sources 30 as known in the art of the present disclosure and hereinafter conceived including, but not limited to, Point-of-Care (POC) tester, and ultrasound.

When physiological data source(s) 30 are employed in system 10, resuscitation coordinator 40 utilizes a physiological state of the patent established by the physiological data source(s) 30 as an additional basis for resuscitation procedure coordination of the resuscitation devices.

To this end, resuscitation commander 40 employs a commander for each physiological data source 30.

In one exemplary embodiment, a commander may include an agent for communicating physiological data and for executing any commands as will be further explained in the present disclosure.

Further in practice, a commander of the present disclosure may be external to or installed within a respective device. For example, infusion commander 41 d may be externally coupled to infusion pump 31 or installed within infusion pump 31 as an independent module or within a controller of infusion pump 31.

Still referring to FIG. 1, in operation, resuscitation coordinator 40 executes an closed- loop process for processing 42 performance data received from the resuscitation devices and any physiological data received from the physiological devices, and for coordinating 43 the resuscitation devices in accordance with the resuscitation procedure in view of the performance data and the physiological data (if any).

In one exemplary embodiment, FIG. 2 illustrates a flowchart 50 representative of a closed-loop resuscitation method of the present disclosure, and FIG. 3 illustrates an exemplary execution of flowchart 50.

Referring to FIGS. 2 and 3, a data processing stage S52 of flowchart 50 encompasses resuscitation coordinator 40 receiving and processing performance data 24 received from the resuscitation devices and any physiological data 34 received from the physiological devices. As previously described herein, performance data 24 will be indicative of a performance of two or more artificial circulation of the blood by chest compressor 20, a shock therapy by electrical therapeutic device 21 and a ventilation therapy by ventilator 22.

Further, physiological data 34 will be indicative of a physiological state of the patient corresponding to one or more of the performance of the artificial circulation of the blood by chest compressor 20, the performance of the shock therapy by electrical therapeutic device 21, the performance of the ventilation therapy by ventilator 22 and the performance of the infusion delivery by the infusion pump 23.

Still referring to FIGS. 2 and 3, a resuscitation coordinating stage S54 of flowchart 50 encompasses resuscitation coordinator 40 generating and communication performance command(s) 25 to two or more of the resuscitation devices, and physiological command(s) 35 (if applicable) to one or more physiological device(s).

As previously described herein, the performance command(s) 25 will be instructive of a delineation, a synchronization, a modification and/or an adjustment of the operations of the resuscitation devices, and the physiological command(s) 35 will be instructive of any modification and/or an adjustment of a physiological state of the patient.

Referring to FIG. 4, shown is an exemplary embodiment of controller 60 that includes one or more processor(s) 61, memory 62, a user interface 63, a network interface 64, and a storage 65 interconnected via one or more system bus(es) 66.

Each processor 61 can be any hardware device, as known in the art of the present disclosure or hereinafter conceived, capable of executing instructions stored in memory 62 or storage or otherwise processing data. In a non-limiting example, the processor(s) 61 can include a microprocessor, field programmable gate array (FPGA), application-specific integrated circuit (ASIC), or other similar devices.

The memory 62 can include various memories, as known in the art of the present disclosure or hereinafter conceived, including, but not limited to, LI, L2, or L3 cache or system memory. In a non-limiting example, the memory 62 can include static random access memory (SRAM), dynamic RAM (DRAM), flash memory, read only memory (ROM), or other similar memory devices. The user interface 63 can include one or more devices, as known in the art of the present disclosure or hereinafter conceived, for enabling communication with a user such as an administrator. In a non-limiting example, the user interface can include a command line interface or graphical user interface that can be presented to a remote terminal via the network interface 64.

The network interface 64 can include one or more devices, as known in the art of the present disclosure or hereinafter conceived, for enabling communication other components of a medical device. In a non-limiting example, the network interface 64 can include a network interface card (NIC) configured to communicate according to the Ethernet protocol. Additionally, the network interface 64 may implement a TCP/IP stack for communication according to the TCP/IP protocols. Various alternative or additional hardware or configurations for the network interface 64 will be apparent.

The storage 65 can include one or more machine-readable storage media, as known in the art of the present disclosure or hereinafter conceived, including, but not limited to, read-only memory (ROM), random-access memory (RAM), magnetic disk storage media, optical storage media, flash-memory devices, or similar storage media. In various non-limiting embodiments, the storage 65 can store instructions for execution by the processor(s) 61 or data upon with the processor(s) 61 may operate. For example, the storage 65 may store a base operating system for controlling various basic operations of the hardware.

The storage 65 can also store an application modules in the form of executable software/firmware for implementing the various functions of the method of FIG. 2 as previously described in the present disclosure.

In one exemplary embodiment as shown, storage 65 stores application modules 67 including data processor 68 to implement stage S52 of flowchart 50 of FIG. 2 and a resuscitation coordinator 69 to implement stages S54 of FIG. 2.

In practice, resuscitation coordinator 60 may be installed in various types of devices, such as, for example, a tablet 70, a monitor 71, and a monitor/defibrillator 72 as shown in FIG. 4.

From the description of FIGS. 1-4 herein, those having ordinary skill in the art will appreciate the numerous benefits of the present disclosure including, but not limited to, a coordination of device(s) during a resuscitation of the patient, particularly based on real-time measurements of a manual performance and/or an automated performance of resuscitation by the device(s) and/or real-time measurement(s)/assessment(s) of a physiological state of the patient.

The present disclosure has been described with reference to the preferred embodiments. Modifications and alterations may occur to others upon reading and understanding the preceding detailed description. It is intended that the invention be construed as including all such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.

Further, as one having ordinary skill in the art shall appreciate in view of the teachings provided herein, features, elements, components, etc. disclosed and described in the present disclosure/specification and/or depicted in the appended Figures and/or recited in the claims can be implemented in various combinations of hardware and software, and provide functions which may be combined in a single element or multiple elements. For example, the functions of the various features, elements, components, etc. shown/illustrated/depicted in the Figures and/or recited in the claims can be provided through the use of dedicated hardware as well as hardware capable of executing software in association with appropriate software. When provided by a processor, the functions can be provided by a single dedicated processor, by a single shared processor, or by a plurality of individual processors, some of which can be shared and/or multiplexed. Moreover, explicit use of the term “processor” or “controller” should not be construed to refer exclusively to hardware capable of executing software, and can implicitly include, without limitation, digital signal processor (“DSP”) hardware, memory (e.g., read only memory (“ROM’) for storing software, random access memory (“RAM’), non-volatile storage, etc.) and virtually any means and/or machine (including hardware, software, firmware, combinations thereof, etc.) which is capable of (and/or configurable) to perform and/or control a process.

Moreover, all statements herein reciting principles, aspects, and exemplary embodiments of the present disclosure, as well as specific examples thereof, are intended to encompass both structural and functional equivalents thereof. Additionally, it is intended that such equivalents include both currently known equivalents as well as equivalents developed in the future (e.g., any elements developed that can perform the same or substantially similar functionality, regardless of structure). Thus, for example, it will be appreciated by one having ordinary skill in the art in view of the teachings provided herein that any block diagrams presented herein can represent conceptual views of illustrative system components and/or circuitry embodying the principles of the invention. Similarly, one having ordinary skill in the art should appreciate in view of the teachings provided herein that any flow charts, flow diagrams and the like can represent various processes which can be substantially represented in computer readable storage media and so executed by a computer, processor or other device with processing capabilities, whether or not such computer or processor is explicitly shown.

Having described preferred and exemplary embodiments of the present disclosure, which embodiments are intended to be illustrative and not limiting, it is noted that modifications and variations can be made by persons having ordinary skill in the art in view of the teachings provided herein, including the appended Figures and claims. It is therefore to be understood that changes can be made in/to the preferred and exemplary embodiments of the present disclosure which are within the scope of the present disclosure and exemplary embodiments disclosed, described and taught herein.

Moreover, it is contemplated that corresponding and/or related systems incorporating and/or implementing the device or such as may be used/implemented in a device in accordance with the present disclosure are also contemplated and considered to be within the scope of the present disclosure. Further, corresponding and/or related method for manufacturing and/or using a device and/or system in accordance with the present disclosure are also contemplated and considered to be within the scope of the present disclosure.

Claims

1. A closed loop resuscitation system (10) for coordinating at least two of an artificial circulation of blood of a patient, a shock therapy of the patient, a ventilation therapy of the patient and an infusion delivery of the patient, the closed loop resuscitation system (10) comprising: at least two of: a chest compressor (20) operable to perform the artificial circulation of blood of the patient; an electrical therapeutic device (21) operable to perform the shock therapy of the patient; a ventilator (22) operable to perform the ventilation therapy of the patient; and an infusion pump (23) operable to perform the infusion delivery of the patient; and a resuscitation coordinator (40) configured to coordinate, in accordance with a resuscitation procedure, at least two of: a performance of the artificial circulation of blood by the chest compressor (20); a performance of the shock therapy of the patient by the electrical therapeutic device (21); a performance of the ventilation therapy of the patient by the ventilator (22); and a performance of the infusion delivery of the patient by the infusion pump (23).

2. The closed loop resuscitation system (10) of claim 1, wherein the resuscitation coordinator (40) being configured to coordinate in accordance with the resuscitation procedure includes at least one of: the resuscitation coordinator (40) configured to command a delineation, in accordance with the resuscitation procedure, at least two of the performance of the artificial circulation of blood by the chest compressor (20), the performance of the shock therapy of the patient by the electrical therapeutic device (21), the performance of the ventilation therapy of the patient by the ventilator (22), and the performance of the infusion delivery of the patient by the infusion pump (23); and the resuscitation coordinator (40) configured to command a synchronization, in accordance with the resuscitation procedure, at least two of the performance of the artificial circulation of blood by the chest compressor (20), the performance of the shock therapy of the patient by the electrical therapeutic device (21), and the performance of the ventilation therapy of the patient by the ventilator (22), and the performance of the infusion delivery of the patient by the infusion pump (23).

3. The closed loop resuscitation system (10) of claim 1, wherein the resuscitation coordinator (40) being configured to coordinate in accordance with the resuscitation procedure includes at least one of: the resuscitation coordinator (40) configured to command a modification, in accordance with the resuscitation procedure, at least one of the performance of the artificial circulation of blood by the chest compressor (20), the performance of the shock therapy of the patient by the electrical therapeutic device (21), the performance of the ventilation therapy of the patient by the ventilator (22), and the performance of the infusion delivery of the patient by the infusion pump (23); and the resuscitation coordinator (40) configured to command an adjustment, in accordance with the resuscitation procedure, at least one of the performance of the artificial circulation of blood by the chest compressor (20), the performance of the shock therapy of the patient by the electrical therapeutic device (21), the performance of the ventilation therapy of the patient by the ventilator (22), and the performance of the infusion delivery of the patient by the infusion pump (23).

4. The closed loop resuscitation system (10) of claim 1, wherein the resuscitation coordinator (40) is configured to further coordinate, in accordance with the restoration procedure, the at least two of the performance of the artificial circulation of blood by the chest compressor (20), the performance of the shock therapy of the patient by the electrical therapeutic device (21), the performance of the ventilation therapy of the patient by the ventilator (22), and the performance of the infusion delivery of the patient by the infusion pump (23) based on a physiological state of the patient corresponding to at least one of the performance of the artificial circulation of blood by the chest compressor (20), the performance of the shock therapy of the patient by the electrical therapeutic device (21), the performance of the ventilation therapy of the patient by the ventilator (22), and the performance of the infusion delivery of the patient by the infusion pump (23).

5. The closed loop resuscitation system (10) of claim 4, wherein the resuscitation coordinator (40) is configured to further coordinate in accordance with the resuscitation procedure includes: the resuscitation coordinator (40) configured to command, in accordance with the resuscitation procedure, at least one of a modification and an adjustment of at least one of a plurality of physiological data sources (30).

6. A resuscitation coordinator (40) for coordinating at least two of an artificial circulation of blood of a patient, a shock therapy of the patient, a ventilation therapy of the patient and a performance of an infusion delivery, the resuscitation coordinator (40) comprising: a non-transitory machine-readable storage medium encoded with instructions for execution by at least one processor, the non-transitory machine-readable storage medium including the instructions to: coordinate, in accordance with a resuscitation procedure, at least two of a performance of the artificial circulation of blood by a chest compressor (20), a performance of a shock therapy of the patient by an electrical therapeutic device (21), a performance of the ventilation therapy of the patient by a ventilator (22), and the performance of the infusion delivery of the patient by the infusion pump (23).

7. The resuscitation coordinator (40) of claim 6, wherein the instructions to coordinate in accordance with the resuscitation procedure includes: command a delineation, in accordance with the resuscitation procedure, at least two of the performance of the artificial circulation of blood by the chest compressor (20), the performance of the shock therapy of the patient by the electrical therapeutic device (21), the performance of the ventilation therapy of the patient by the ventilator (22), and the performance of the infusion delivery of the patient by the infusion pump (23); and command a synchronization, in accordance with the resuscitation procedure, at least two of the performance of the artificial circulation of blood by the chest compressor (20), the performance of the shock therapy of the patient by the electrical therapeutic device (21), and the performance of the ventilation therapy of the patient by the ventilator (22), and the performance of the infusion delivery of the patient by the infusion pump (23).

8. The resuscitation coordinator (40) of claim 6, wherein the instructions to coordinate in accordance with the resuscitation procedure includes: command a modification, in accordance with the resuscitation procedure, at least one of the performance of the artificial circulation of blood by the chest compressor (20), the performance of the shock therapy of the patient by the electrical therapeutic device (21), the performance of the ventilation therapy of the patient by the ventilator (22), and the performance of the infusion delivery of the patient by the infusion pump (23); and command an adjustment, in accordance with the resuscitation procedure, at least one of the performance of the artificial circulation of blood by the chest compressor (20), the performance of the shock therapy of the patient by the electrical therapeutic device (21), and the performance of the ventilation therapy of the patient by the ventilator (22), and the performance of the infusion delivery of the patient by the infusion pump (23).

9. The resuscitation coordinator (40) of claim 6, wherein the non-transitory machine- readable storage medium further includes instructions to: coordinate, in accordance with the restoration procedure, the at least two of the performance of the artificial circulation of blood by the chest compressor (20), the performance of the shock therapy of the patient by the electrical therapeutic device (21), the performance of the ventilation therapy of the patient by the ventilator (22), and the performance of the infusion delivery of the patient by the infusion pump (23) based on a physiological state of the patient corresponding to at least one of the performance of the artificial circulation of blood by the chest compressor (20), the performance of the shock therapy of the patient by the electrical therapeutic device (21) and the performance of the ventilation therapy of the patient by the ventilator (22).

10. The resuscitation coordinator (40) of claim 9, wherein the instructions to coordinate in accordance with the resuscitation procedure includes: command, in accordance with the resuscitation procedure, at least one of a modification and an adjustment of one of a plurality of physiological data sources (30).

11. A closed loop resuscitation method for coordinating at least two of an artificial circulation of blood of a patient, a shock therapy of the patient, a ventilation therapy of the patient, and an infusion delivery of the patient the closed loop resuscitation system (10) method: performing at least two of: the artificial circulation of blood of the patient by a chest compressor (20); the shock therapy of the patient by an electrical therapeutic device (21); the ventilation therapy of the patient by a ventilator (22); and the infusion delivery of the patient by an infusion pump (23); and coordinating, by a resuscitation coordinator (40) in accordance with a resuscitation procedure, at least two of: the performance of the artificial circulation of blood by the chest compressor (20); the performance of the shock therapy of the patient by the electrical therapeutic device (21); and the performance of the ventilation therapy of the patient by the ventilator (22), and the performance of the infusion delivery of the patient by the infusion pump (23).

12. The closed loop resuscitation method of claim 11, wherein the coordinating by the resuscitation coordinator (40) in accordance with the resuscitation procedure includes at least one of: commanding, by the resuscitation coordinator (40) in accordance with the resuscitation procedure, a delineation of at least two of the performance of the artificial circulation of blood by the chest compressor (20), the performance of the shock therapy of the patient by the electrical therapeutic device (21), the performance of the ventilation therapy of the patient by the ventilator

(22), and the performance of the infusion delivery of the patient by the infusion pump (23); and commanding, by the resuscitation coordinator (40) in accordance with the resuscitation procedure, a synchronization at least two of the performance of the artificial circulation of blood by the chest compressor (20), the performance of the shock therapy of the patient by the electrical therapeutic device (21), the performance of the ventilation therapy of the patient by the ventilator (22), and the performance of the infusion delivery of the patient by the infusion pump

(23).

13. The closed loop resuscitation method of claim 11, wherein the coordinating by the resuscitation coordinator (40) in accordance with the resuscitation procedure includes at least one of: commanding, by the resuscitation coordinator (40) in accordance with the resuscitation procedure, a modification of at least one of the performance of the artificial circulation of blood by the chest compressor (20), the performance of the shock therapy of the patient by the electrical therapeutic device (21), the performance of the ventilation therapy of the patient by the ventilator (22), and the performance of the infusion delivery of the patient by the infusion pump (23); and commanding, by the resuscitation coordinator (40) in accordance with the resuscitation procedure, an adjustment at least one of the performance of the artificial circulation of blood by the chest compressor (20), the performance of the shock therapy of the patient by the electrical therapeutic device (21), the performance of the ventilation therapy of the patient by the ventilator (22), and the performance of the infusion delivery of the patient by the infusion pump (23).

14. The closed loop resuscitation method of claim 11, wherein the coordinating, by the resuscitation coordinator (40) in accordance with the resuscitation procedure, the at least two of the performance of the artificial circulation of blood by the chest compressor (20), the performance of the shock therapy of the patient by the electrical therapeutic device (21), the performance of the ventilation therapy of the patient by the ventilator (22), and the performance of the infusion delivery of the patient by the infusion pump (23) is based on a physiological state of the patient corresponding to at least one of the performance of the artificial circulation of blood by the chest compressor (20), the performance of the shock therapy of the patient by the electrical therapeutic device (21), the performance of the ventilation therapy of the patient by the ventilator (22), and the performance of the infusion delivery of the patient by the infusion pump (23). 15. The closed loop resuscitation method of claim 14, wherein the coordinating, by the resuscitation coordinator (40) in accordance with the resuscitation procedure includes: commanding, by the resuscitation coordinator (40) in accordance with the resuscitation procedure, at least one of a modification and an adjustment of at least one of a plurality of physiological data sources (30).