WO2025004436A1 - 試料分析システム - Google Patents

試料分析システム Download PDF

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Publication number
WO2025004436A1
WO2025004436A1 PCT/JP2024/005820 JP2024005820W WO2025004436A1 WO 2025004436 A1 WO2025004436 A1 WO 2025004436A1 JP 2024005820 W JP2024005820 W JP 2024005820W WO 2025004436 A1 WO2025004436 A1 WO 2025004436A1
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Prior art keywords
sample
flow path
liquid
analysis
liquid supply
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Ceased
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PCT/JP2024/005820
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English (en)
French (fr)
Japanese (ja)
Inventor
塁 加藤
伸彦 西
知義 松下
幸子 若杉
健介 大穂
裕子 小林
徹也 才村
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Shimadzu Corp
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Shimadzu Corp
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Priority to JP2025529431A priority Critical patent/JPWO2025004436A1/ja
Priority to CN202480037145.0A priority patent/CN121241260A/zh
Publication of WO2025004436A1 publication Critical patent/WO2025004436A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Definitions

  • the present invention relates to a sample analysis system that includes an autosampler and a sample analysis device that analyzes a liquid sample supplied from the autosampler.
  • an autosampler When performing continuous analysis of multiple liquid samples using an analytical device such as a mass spectrometer or liquid chromatograph, an autosampler is generally used that automatically and sequentially collects liquid samples one by one from a large number of sample containers prepared in advance and introduces them into the analytical device (see, for example, Patent Document 1).
  • the autosampler includes, for example, a tray arrangement section in which one or more sample trays are arranged with multiple sample containers containing samples, a bottle arrangement section in which one or more bottles containing cleaning liquid or calibration samples (hereinafter collectively referred to as "cleaning liquid, etc.") are arranged, an aspiration nozzle for aspirating liquid from the sample container or bottle, and a nozzle movement mechanism for moving the aspiration nozzle horizontally and vertically.
  • the analyst When performing automatic continuous analysis using a sample analysis system including such an autosampler and analyzer, the analyst first places multiple sample containers containing the samples to be analyzed on a sample tray, sets the sample tray in the tray arrangement section within the autosampler, and sets bottles containing cleaning solutions, etc., in the bottle arrangement section. The analyst then performs setting operations related to the automatic continuous analysis in a control device (typically a personal computer equipped with dedicated control software) for controlling the autosampler and analyzer.
  • a control device typically a personal computer equipped with dedicated control software
  • the setting operation sets items such as which sample container (or bottle containing a calibration sample) in the autosampler the sample will be taken from for each analysis step in the automatic continuous analysis (i.e., the position of the suction nozzle in each analysis step), what analysis conditions will be applied to each analysis, when during the automatic continuous analysis the flow path cleaning step will be performed with cleaning liquid, and from which bottle in the autosampler the cleaning liquid will be taken in the cleaning step (i.e., the position of the suction nozzle in the cleaning step).
  • the sample analysis system is provided with a flow path switching valve for connecting one of one or more flow paths through which the cleaning liquid or the like collected from the one or more large-capacity bottles flows and one of the flow paths through which the liquid collected by the autosampler flows, to a flow path leading to the analysis device.
  • This configuration allows the number of steps included in the continuous automatic analysis to be increased compared to the conventional configuration, but on the other hand, the analyst must set in advance the position of the flow path switching valve in each step in addition to the position of the suction nozzle in the autosampler in each step, which increases the workload of the analyst in the setting operation. For example, for a step of analyzing a liquid sample contained in one of the sample containers in the autosampler, it is necessary to set the tip of the suction nozzle so that it is inserted into the target sample container, and to set the position of the flow path switching valve so that the flow path through which the liquid sample collected by the autosampler flows is connected to the flow path leading to the analysis device.
  • a predetermined standby position for example, a position that is not inserted into any sample container or bottle, or a position that is inserted into a specific sample container or bottle such as a cleaning solution bottle
  • the position of the flow path switching valve so that the flow path through which the liquid collected from the large-capacity bottle containing the calibration sample flows is connected to the flow path leading to the analysis device.
  • the suction nozzle must be set to the standby position, and the position of the flow path switching valve must be set so that the flow path through which the liquid collected from the large-capacity bottle containing the cleaning liquid flows is connected to the flow path leading to the analysis device.
  • the present invention was made in consideration of the above problems, and its purpose is to provide a sample analysis system that can perform continuous automatic analysis with a greater number of steps than conventional systems, and that allows easy setup operations for the continuous automatic analysis.
  • the sample analysis system which has been made to solve the above problems, comprises: A sample analyzer; an autosampler including a plate placement section on which a sample plate having a plurality of sample storage sections each containing a liquid sample is placed, a nozzle for aspirating liquid from one of the plurality of sample storage sections, a sampling flow path into which the liquid aspirated by the nozzle is fed, and a movement mechanism for moving the nozzle in horizontal and vertical directions;
  • One or more liquid supply units provided outside the autosampler; a flow path switching valve that selectively connects one of the one or more liquid supply units and the sampling flow path to a flow path leading to the sample analyzer; a control device for controlling the operation of at least the sample analyzer, the autosampler, and the flow path switching valve to execute automatic continuous analysis including a plurality of sample analysis steps and one or more cleaning steps; Equipped with The control device, a selection receiving unit that displays buttons or identifiers corresponding to each of the plurality of sample receptacles and
  • the sample analysis system according to the present invention having the above configuration can perform continuous automatic analysis with a greater number of steps than conventional methods, and can also easily perform the setting operations for the continuous automatic analysis.
  • FIG. 1 is a schematic configuration diagram of a sample analysis system according to an embodiment of the present invention.
  • FIG. 4 shows an example of a washing condition setting screen in the sample analyzing system.
  • FIG. 4 shows an example of a sample/washing solution position selection screen in the sample analyzing system.
  • FIG. 4 shows an example of a batch setting screen in the sample analyzing system.
  • 4 is a flowchart showing a control procedure for the flow path switching valve and the autosampler at the start of each analysis step and cleaning step of the automatic continuous analysis by the sample analysis system.
  • FIG. 4 shows an example of a drop-down list in the sample analyzing system.
  • FIG. 1 is a schematic diagram of a sample analysis system according to this embodiment.
  • This sample analysis system (hereinafter sometimes simply referred to as the system) is a system for performing automatic continuous analysis of multiple liquid samples, and includes a mass spectrometer 100 (corresponding to the sample analysis device in this invention), an autosampler 200, a calibration sample supply unit 300, a first cleaning liquid supply unit 400, a second cleaning liquid supply unit 500, a flow path switching valve 600, and a control device 700.
  • the mass spectrometer 100 is an ICP mass spectrometer equipped with an ion source 102 that ionizes a liquid sample by introducing it into an inductively coupled plasma (ICP) generated by a plasma torch 101, a mass separation section 103 that separates the ions generated by the ion source 102 based on m/z (mass-to-charge ratio), and a detector 104 that detects the ions separated by the mass separation section 103.
  • ICP inductively coupled plasma
  • the autosampler 200 comprises a tray arrangement section 203 (corresponding to the plate arrangement section in this invention) in which multiple sample trays 202 (corresponding to the sample plate in this invention) can be arranged, a bottle arrangement section 205 (corresponding to the liquid container arrangement section in this invention) in which one or more small-capacity bottles 204 (corresponding to the liquid container in this invention), which are relatively small-capacity bottles containing a specified liquid, a sampling needle 206 (corresponding to the nozzle in this invention) with a suction port at its tip and used to collect liquid (liquid sample or the specified liquid) from multiple sample containers 201 (corresponding to the sample storage section in this invention) mounted on the sample tray 202 or the small-capacity bottles 204 arranged in the bottle arrangement section 205, a needle moving mechanism 207 (corresponding to the moving mechanism in this invention) including a motor or the like not shown, and a sampling flow path 208 connected to the base end of the sampling needle 206.
  • a tray arrangement section 203 corresponding to the plate arrangement section in this invention
  • the sampling needle 206 can be moved horizontally (X-axis and Y-axis directions in the figure) and vertically (Z-axis direction in the figure) by a needle moving mechanism 207, and can move over the multiple sample containers 201 and multiple small-capacity bottles 204 in the autosampler 200 and insert its tip into each of them. Furthermore, the sampling needle 206 can also be moved to a standby position 209 where its tip is not inserted into any of the multiple sample containers 201 and multiple small-capacity bottles 204.
  • the standby position is a position where the tip of the sampling needle 206 is not inserted into any of the sample containers 201 and small-capacity bottles 204, but instead, the standby position may be a position where the tip of the sampling needle 206 is inserted into a specific sample container 201 or small-capacity bottle 204.
  • the sampling flow path 208 is connected to the base of the sampling needle 206, but the sampling flow path 208 may be connected to an injection port (not shown) provided in the autosampler 200, and after liquid is collected by the sampling needle 206, the tip of the sampling needle 206 is inserted into the injection port and the liquid is ejected, thereby sending the liquid into the sampling flow path 208.
  • the calibration sample supply unit 300 includes a calibration sample bottle 301, which is a large-capacity bottle in which a calibration sample is stored, and a calibration sample flow path 302, one end of which is inserted into the calibration sample bottle 301 and through which the calibration sample collected from the bottle 301 flows.
  • "large capacity” means a larger volume than the small-capacity bottle 204 described above (same below).
  • the first cleaning liquid supply unit 400 includes a first cleaning liquid bottle 401, which is a large-capacity bottle in which a first cleaning liquid (e.g., water, a specified organic solvent, a mixture of water and a specified organic solvent, or a specified acid such as hydrochloric acid or nitric acid) is stored, and a first cleaning liquid flow path 402, one end of which is inserted into the first cleaning liquid bottle 401 and through which the first cleaning liquid collected from the bottle 401 flows.
  • a first cleaning liquid e.g., water, a specified organic solvent, a mixture of water and a specified organic solvent, or a specified acid such as hydrochloric acid or nitric acid
  • the second cleaning liquid supply unit 500 includes a second cleaning liquid bottle 501, which is a large-capacity bottle that stores a second cleaning liquid that is a different type of cleaning liquid from the first cleaning liquid, and a second cleaning liquid flow path 502, one end of which is inserted into the second cleaning liquid bottle 501 and through which the second cleaning liquid collected from the bottle 501 flows.
  • the calibration sample supply unit 300, the first cleaning liquid supply unit 400, and the second cleaning liquid supply unit 500 each correspond to a liquid supply unit in the present invention.
  • the flow path switching valve 600 is a four-way rotary valve equipped with one outlet port 610 and four inlet ports.
  • the four inlet ports are referred to as the first port 621, the second port 622, the third port 623, and the fourth port 624.
  • the outlet port 610 is connected to the mass analysis flow path 105 (corresponding to the "flow path leading to the mass analysis device" in this invention), which is a flow path leading to the plasma torch 101 provided in the ion source 102 of the mass analysis device 100.
  • a liquid delivery pump 900 consisting of, for example, a peristaltic pump is provided on the mass analysis flow path 105.
  • the sampling flow path 208 of the autosampler 200 is connected to the first port 621, and the other end of the calibration sample flow path 302 is connected to the second port 622.
  • the other end of the first cleaning liquid flow path 402 is connected to the third port 623, and the other end of the second cleaning liquid flow path 502 is connected to the fourth port 624.
  • the flow path switching valve 600 can be selectively switched between a state in which the outlet port 610 and the first port 621 are connected (i.e., a state in which the autosampler 200 is connected to the mass spectrometer 100), a state in which the outlet port 610 and the second port 622 are connected (i.e., a state in which the calibration sample supply unit 300 is connected to the mass spectrometer 100), a state in which the outlet port 610 and the third port 623 are connected (i.e., a state in which the first cleaning liquid supply unit 400 is connected to the mass spectrometer 100), and a state in which the outlet port 610 and the fourth port 624 are connected (i.e., a state in which the second cleaning liquid supply unit 500 is connected to the mass spectrometer 100).
  • the control device 700 has a setting/selection screen generating unit 701, a display control unit 702, an analysis control unit 703, a liquid supply source information storage unit 704, and a setting information storage unit 705 (details of each unit will be described later).
  • the functions of the control device 700 are realized by a computer (typically a personal computer) equipped with a CPU, memory, and a large-capacity storage medium such as a hard disk drive (HDD) or a solid-state device (SDD).
  • a predetermined program is installed in the computer, and the functions of the setting/selection screen generating unit 701, the display control unit 702, and the analysis control unit 703 in this system are realized in software form by the CPU executing this program.
  • the functions of the liquid supply source information storage unit 704 and the setting information storage unit 705 are realized by the large-capacity storage medium.
  • a display unit 706 for displaying various information and an input unit 707 for the user to input various instructions are connected to the computer.
  • the display unit 706 is composed of, for example, a liquid crystal display
  • the input unit 707 is composed of, for example, a pointing device such as a keyboard or a mouse, or a touch panel attached to the display unit 706.
  • the analysis control unit 703 corresponds to the liquid supply control unit in the present invention.
  • the setting/selection screen generating unit 701, the display control unit 702, the display unit 706, and the input unit 707 collectively function as the selection receiving unit in the present invention.
  • the liquid supply source information storage unit 704 stores plan view data showing the positions of each sample container 201 and each small-capacity bottle 204 when the sample trays 202 and small-capacity bottles 204 are arranged in the autosampler 200, by type and number of sample trays 202 arranged in the tray arrangement unit 203.
  • the user places a sample tray 202 carrying multiple sample containers 201 in the tray placement section 203 of the autosampler 200, places a small-capacity bottle 204 containing a predetermined liquid (e.g., a standard sample, or a type of cleaning liquid different from the first and second cleaning liquids described above) in the bottle placement section 205 of the autosampler 200, and then performs setup work for the automatic continuous analysis.
  • a predetermined liquid e.g., a standard sample, or a type of cleaning liquid different from the first and second cleaning liquids described above
  • the procedure for this setup work is explained below. Note that the following explanation is given by taking as an example a case in which four sample trays 202 of 2mL x 24 type (i.e. a type capable of carrying 24 sample containers 201 with a capacity of 2mL) are placed in the tray placement section 203.
  • the user inputs a predetermined instruction to the control device 700 via the input unit 707.
  • a predetermined setting screen (not shown) is generated by the setting/selection screen generating unit 701, and the setting screen is displayed on the screen of the display unit 706 under the control of the display control unit 702.
  • the user operates the input unit 707 to specify on the setting screen the type (here, "2 mL x 24") and number (here, "4") of sample trays 202 set in the autosampler 200.
  • a cleaning condition setting screen 810 as shown in FIG. 2 is generated by the setting/selection screen generating unit 701 and displayed on the screen of the display unit 706 under the control of the display control unit 702.
  • This screen 810 allows the user to set the cleaning time, the rotation speed of the pump that supplies the cleaning liquid (i.e., the liquid delivery pump 900), and the source of the cleaning liquid for the cleaning process that is performed at a predetermined timing during automatic continuous analysis (e.g., each time the analysis of each sample is completed).
  • the user can specify the execution timing of the cleaning process as appropriate on a predetermined setting screen (not shown).
  • the cleaning condition setting screen 810 has a cleaning time input field 811, a pump RPM input field 812, and a cleaning solution supply source input field 813, and the user operates the input unit 707 to input desired values into the cleaning time input field 811 and the pump RPM input field 812.
  • a sample/cleaning solution position selection screen 820 as shown in FIG. 3 is generated by the setting/selection screen generation unit 701 and is displayed on the screen of the display unit 706 under the control of the display control unit 702.
  • the sample and cleaning liquid position selection screen 820 includes a plan view 821 showing the position of each sample tray 202 in the autosampler 200, the position of each sample container 201 on each sample tray 202, and the position of each small-capacity bottle 204.
  • This plan view 821 corresponds to the type and number of sample trays 202 specified by the user above, and is read from the liquid supply source information storage unit 704 and displayed.
  • the figures (circles in the example of FIG. 3, but not limited to this) indicating the position of each sample container 201 and each small-capacity bottle 204 are each buttons.
  • buttons indicating the position of each sample container 201 will be referred to as sample position buttons 822
  • the buttons indicating the position of the small-capacity bottles 204 will be referred to as bottle position buttons 823.
  • the sample position button 822 is assigned a unique identifier for each sample position ("01" to "96” in the example of Figure 3)
  • the bottle position button 823 is assigned a unique identifier for the position of each small-capacity bottle 204 ("R0" to "R4" in the example of Figure 3).
  • the sample/cleaning solution position selection screen 820 further includes buttons (hereinafter referred to as valve port buttons 824) corresponding to the inlet ports 621-624 of the flow path switching valve 600 other than the one to which the autosampler 200 is connected, i.e., the second port 622, the third port 623, and the fourth port 624.
  • the valve port buttons 824 are provided with identifiers corresponding to the inlet ports 621-624 and their connection destinations. In the example of FIG.
  • each valve port button 824 refers to the second port 622, the third port 623, and the fourth port 624, respectively, and the characters “TUNE”, "WS1", and “WS2” following these characters refer to the connection destinations of the ports 622, 623, and 624, respectively, to the calibration sample bottle 301, the first cleaning solution bottle 401, and the second cleaning solution bottle 501.
  • These identifiers are registered in advance by the user, etc., and stored in the liquid supply source information storage unit 704.
  • buttons 822, 823, and 824 displayed on the sample/cleaning liquid position selection screen 820 the button that corresponds to the appropriate liquid supply source in the cleaning process.
  • the user selected valve port button 824 corresponding to the fourth port 624 of the flow path switching valve 600 on the sample/cleaning liquid position selection screen 820 is assumed that the user selected valve port button 824 corresponding to the fourth port 624 of the flow path switching valve 600 on the sample/cleaning liquid position selection screen 820.
  • the fourth port 624 (strictly speaking, the second cleaning liquid supply unit 500 connected to said port 624) is determined as the supply source of cleaning liquid in the cleaning process, and is stored in the setting information storage unit 705 together with the cleaning time and pump rotation speed values entered on the cleaning condition setting screen 810.
  • the batch setting screen 830 includes a batch table 831 in which the order of execution and the like of the multiple analysis steps included in the automatic continuous analysis are described.
  • one row corresponds to an analysis step for one sample, and each row describes the information necessary to perform the analysis, such as the analysis category, the number of analyses, the name of the sample to be analyzed, the position of the sample to be analyzed, and the amount of sample collected.
  • the analysis category refers to whether the analysis is for calibrating the device, analysis of a standard sample for creating a calibration curve, or analysis of an unknown sample.
  • the first line of the column (second column) in which the analysis category is described contains the word "TUNE” to indicate an analysis for calibrating the device
  • the second to fourth lines contain the words "CAL1,” "CAL2,” or "CAL3” to indicate an analysis of a standard sample for creating a calibration curve
  • the fifth and sixth lines contain the word "UNK" to indicate an analysis of an unknown sample.
  • sample position description column 832 When the user selects any cell in the column in which the position of the sample to be analyzed is described (hereinafter referred to as the sample position description column 832) in the above batch table 831, a sample and cleaning solution position selection screen 820 similar to that shown in Figure 3 is displayed on the screen of the display unit 706.
  • the identifier corresponding to the pressed button is entered into the cell on the batch table 831.
  • the first line of the sample position description column 832 contains the characters "VA2:TUNE”, which is an identifier representing the second port 622 of the flow path switching valve 600 connected to the calibration sample supply unit 300
  • the second to fourth lines of the same column 832 contain the characters "R1", “R2”, and “R3”, which are identifiers corresponding to specific small-capacity bottles 204 arranged in the bottle arrangement unit 205 of the autosampler 200
  • the fifth and sixth lines of the same column 832 contain the characters "01” and "02”, which are identifiers corresponding to the first and second sample containers 201 of the multiple sample containers 201 mounted on the first sample tray 202 (the upper left sample tray 202 in FIG. 3) of the four sample trays 202 arranged in the tray arrangement unit 203.
  • the user When the user inputs the necessary information into the batch table 831 in the manner described above and then presses the analysis start button 833 on the batch setting screen 830, the contents entered in the batch table 831 on the batch setting screen 830 are stored in the setting information storage unit 705 in association with the above-mentioned cleaning conditions, and automatic continuous analysis based on the batch table 831 and the above-mentioned cleaning conditions is started.
  • the analysis steps defined in each row of the batch table 831 are executed in order, and the cleaning steps defined in the above-mentioned cleaning conditions are executed at predetermined timing.
  • the operation of the flow path switching valve 600 and the needle movement mechanism 207 of the autosampler 200 is controlled so that the sample or cleaning solution specified in the batch table 831 or the above-mentioned cleaning conditions for that step is supplied to the mass spectrometer 100. The procedure at this time will be explained below with reference to the flowchart in Figure 5.
  • the analysis control unit 703 determines whether the source of the liquid (sample or cleaning liquid) to be used in the process to be executed (analysis process or cleaning process) exists within the autosampler 200 based on the batch table 831 stored in the setting information storage unit 705 or the cleaning conditions (step 1). For example, if the process to be executed is an analysis process, the analysis control unit 703 refers to the identifier described in the sample position description column 832 in the row corresponding to the analysis process in the batch table 831, and if the process to be executed is a cleaning process, it refers to the identifier indicating the source of the cleaning liquid specified in the cleaning conditions.
  • the analysis control unit 703 controls the flow path switching valve 600 so that the autosampler 200 is connected to the mass spectrometer 100 (i.e., the outlet port 610 and the first port 621 are connected) (step 2), and further controls the needle moving mechanism 207 so that the tip of the sampling needle 206 is inserted into the sample container 201 or the small capacity bottle 204 corresponding to the identifier (step 3). Note that steps 2 and 3 may be performed in the reverse order.
  • the analysis control unit 703 determines that the liquid supply source is outside the autosampler 200 (i.e., No in step 1).
  • the analysis control unit 703 then controls the flow path switching valve 600 so that the second port 622, the third port 623, or the fourth port 624 that corresponds to the identifier is connected to the mass spectrometer 100 (i.e., the second port 622, the third port 623, or the fourth port 624 that corresponds to the identifier is connected to the outlet port 610) (step 4), and further controls the needle moving mechanism 207 so that the sampling needle 206 is at the above-mentioned standby position 209 (step 5). Note that steps 4 and 5 may be performed in the reverse order.
  • the liquid delivery pump 900 is operated to supply the sample or cleaning liquid to the mass spectrometer 100, and the sample is analyzed or the flow path is cleaned.
  • the calibration sample, first cleaning liquid, and second cleaning liquid which are liquids used in relatively large quantities, are collected from the calibration sample bottle 301, first cleaning liquid bottle 401, and second cleaning liquid bottle 501, which are large-capacity bottles located outside the autosampler 200, thereby making it possible to avoid shortages of cleaning liquid, etc. during continuous automatic analysis and to accommodate continuous automatic analysis with a greater number of steps than in the past. Furthermore, in the setting operation for the continuous automatic analysis, the user does not need to separately set the position of the sampling needle 206 of the autosampler 200 and the position of the flow path switching valve, which reduces the user's workload and prevents input errors by the user.
  • the sample analyzer in the present invention may be any device capable of analyzing liquid samples, and may be, for example, a mass analyzer other than the above-mentioned ICP mass analyzer (e.g., electrospray ionization mass spectrometry or atmospheric pressure chemical ionization mass spectrometry), or a liquid chromatograph, etc.
  • a mass analyzer other than the above-mentioned ICP mass analyzer e.g., electrospray ionization mass spectrometry or atmospheric pressure chemical ionization mass spectrometry
  • a liquid chromatograph e.g., a liquid chromatograph, etc.
  • sample plate in the present invention is not limited to the sample tray 202 capable of mounting multiple sample containers 201 as described above, but may be, for example, a microplate equipped with multiple wells (recesses) in which liquid samples are held.
  • the wells correspond to the sample holding portion in the present invention.
  • the selection reception unit is not limited to having the user select an appropriate button on the sample/cleaning solution position selection screen 820 as shown in FIG. 3.
  • a drop-down list 840 listing identifiers corresponding to the positions of each sample container 201 and each small-capacity bottle 204 in the autosampler 200, and identifiers corresponding to each inlet port 621-624 (other than those connected to the autosampler) of the flow path switching valve 600 may be displayed on the screen of the display unit 706, and the user may select an appropriate identifier from the identifiers displayed in the drop-down list 840.
  • the system according to the above embodiment is configured to have three liquid supply units, namely, the calibration sample supply unit 300, the first cleaning liquid supply unit 400, and the second cleaning liquid supply unit 500, but the number of liquid supply units in the present invention may be one, two, or four or more.
  • the number of liquid supply units in the present invention may be one, two, or four or more.
  • five small-capacity bottles 204 are arranged in the bottle arrangement unit 205 (corresponding to the liquid container arrangement unit), but the liquid container arrangement unit in the present invention is not limited to this, and one, two to three, or five or more liquid containers may be arranged.
  • a sample analysis system comprises: A sample analyzer; an autosampler including a plate placement section on which a sample plate having a plurality of sample storage sections each containing a liquid sample is placed, a nozzle for aspirating liquid from one of the plurality of sample storage sections, a sampling flow path into which the liquid aspirated by the nozzle is fed, and a movement mechanism for moving the nozzle in horizontal and vertical directions;
  • One or more liquid supply units provided outside the autosampler; a flow path switching valve that selectively connects one of the one or more liquid supply units and the sampling flow path to a flow path leading to the sample analyzer; a control device for controlling the operation of at least the sample analyzer, the autosampler, and the flow path switching valve to execute automatic continuous analysis including a plurality of sample analysis steps and one or more cleaning steps; Equipped with The control device, a selection receiving unit that displays buttons or identifiers corresponding to each of the plurality of sample receptacles and each of the one
  • the sample analysis system according to paragraph 1 eliminates the need for the user to separately set the position of the autosampler's sampling needle and the position of the flow path switching valve, as was the case in the past. This simplifies the setup work for automatic continuous analysis and reduces the occurrence of input errors by the user.
  • the sample analysis system according to the second aspect of the present invention is the sample analysis system according to the first aspect of the present invention
  • the autosampler further has a liquid container arrangement section in which one or more liquid containers are arranged, and the nozzle aspirates liquid from any of the plurality of sample receptacles and the one or more liquid containers
  • the selection receiving unit further displays a button or an identifier corresponding to each of the one or more liquid containers
  • the liquid supply control unit further controls the moving mechanism so that, for a process among the multiple sample analysis processes and the cleaning process, when the button or the identifier corresponding to any of the one or more liquid containers is selected in the selection reception unit, the liquid supply control unit controls the moving mechanism so that the nozzle is inserted into the liquid container corresponding to the button or the identifier, and controls the flow path switching valve so that the sampling flow path is connected to the flow path leading to the sample analysis device.
  • the liquid container disposed in the autosampler can also be selected by the selection reception section as a supply source of liquid to be supplied to the sample analysis device.
  • Mass spectrometer 200 Autosampler 201... Sample container 202... Sample tray 203... Tray placement section 204... Small capacity bottle 205... Bottle placement section 206... Sampling needle 207... Needle moving mechanism 208... Sampling flow path 209... Standby position 300... Calibration sample supply section 400... First cleaning liquid supply section 500... Second cleaning liquid supply section 600... Flow path switching valve 610... Outlet port 621... First port 622... Second port 623... Third port 624...

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PCT/JP2024/005820 2023-06-29 2024-02-19 試料分析システム Ceased WO2025004436A1 (ja)

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JP2025529431A JPWO2025004436A1 (https=) 2023-06-29 2024-02-19
CN202480037145.0A CN121241260A (zh) 2023-06-29 2024-02-19 样品分析系统

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JP2023-107186 2023-06-29

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JP2002031626A (ja) * 2000-05-09 2002-01-31 Tosoh Corp 糖化ヘモグロビン分析計
US20130146479A1 (en) * 2010-05-21 2013-06-13 Antec Leyden B.V. Analytical apparatus comprising an electrochemical flow cell and a structure elucidation spectrometer
JP2015190801A (ja) 2014-03-27 2015-11-02 株式会社島津製作所 自動分析装置用制御装置
JP2022075478A (ja) * 2020-11-05 2022-05-18 株式会社島津製作所 分析システムおよび分析方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002031626A (ja) * 2000-05-09 2002-01-31 Tosoh Corp 糖化ヘモグロビン分析計
US20130146479A1 (en) * 2010-05-21 2013-06-13 Antec Leyden B.V. Analytical apparatus comprising an electrochemical flow cell and a structure elucidation spectrometer
JP2015190801A (ja) 2014-03-27 2015-11-02 株式会社島津製作所 自動分析装置用制御装置
JP2022075478A (ja) * 2020-11-05 2022-05-18 株式会社島津製作所 分析システムおよび分析方法

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