WO2024239607A1 - 一种淋巴结调控系统及方法 - Google Patents

一种淋巴结调控系统及方法 Download PDF

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WO2024239607A1
WO2024239607A1 PCT/CN2023/137647 CN2023137647W WO2024239607A1 WO 2024239607 A1 WO2024239607 A1 WO 2024239607A1 CN 2023137647 W CN2023137647 W CN 2023137647W WO 2024239607 A1 WO2024239607 A1 WO 2024239607A1
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stimulation
information
lymph node
module
data processing
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French (fr)
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赵若棋
宋昊
王立平
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Shenzhen Institute of Advanced Technology of CAS
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Shenzhen Institute of Advanced Technology of CAS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36031—Control systems using physiological parameters for adjustment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A61B5/02055—Simultaneously evaluating both cardiovascular condition and temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A61B5/33—Heart-related electrical modalities, e.g. electrocardiography [ECG] specially adapted for cooperation with other devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/389—Electromyography [EMG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/418—Evaluating particular organs or parts of the immune or lymphatic systems lymph vessels, ducts or nodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0833—Clinical applications involving detecting or locating foreign bodies or organic structures
    • A61B8/085—Clinical applications involving detecting or locating foreign bodies or organic structures for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data

Definitions

  • the present invention relates to the field of medical technology, and in particular to a lymph node regulation system and method.
  • lymphatic circulation can, on the one hand, regulate the balance between plasma and tissue fluid and take away some metabolic products; on the other hand, it can also transport a small amount of protein substances that pass through the blood vessels back into the blood, making it difficult for such macromolecules to penetrate into the capillaries, thereby improving microcirculation.
  • lymphatic system used to execute lymphatic circulation specifically includes lymphatic ducts, lymphatic tissues and lymphatic organs, among which lymphatic organs are composed of lymph nodes, thymus, spleen and tonsils.
  • lymph nodes are not only distributed in the lymphatic channels throughout the body, but also arranged along blood vessels near the inner cavity organs.
  • This important immune tissue organ is not only the place where lymph flows, gathers and filters, but also the place where T lymphocytes and B lymphocytes reside and reproduce, and it is also an important base for the occurrence of immune response. Stimulating lymph nodes through external factors can promote blood and lymph circulation, enhance the phagocytic function of macrophages, improve human immunity, promote recovery of the patient, and thus play a role in strengthening the body and eliminating evil.
  • lymph nodes through external influences, such as acupuncture electrothermal stimulation therapy.
  • This method uses a 25 or 26-gauge, 4-6-inch long needle to penetrate the patient's lymph nodes, and uses an EC-I electrotherapy device to make the patient feel warm and swollen.
  • the stimulated lymph nodes are usually located in the vicinity of the treated area, such as the axillary lymph nodes for the upper limbs and chest, the inguinal lymph nodes for the lower limbs and abdomen, and the lymph nodes behind the ears for the head.
  • the needle retention time is usually 30-40 minutes, once a day, and 12 times as a course of treatment, achieving the purpose of regulating lymph nodes.
  • this method also has obvious shortcomings: on the one hand, the execution of this method requires puncturing the skin, which may cause discomfort to the user or increase the risk of infection; on the other hand, the depth of the needle is not easy to accurately control, the spatial resolution is low, and the target area cannot be accurately stimulated, which affects the effect.
  • the purpose of the present invention is to overcome the shortcomings of the prior art and solve at least one defect in the above-mentioned background technology.
  • the present invention provides the following technical solutions:
  • a lymph node regulation system comprising: a detection module for collecting lymph node image information; a data processing module for acquiring lymph node distribution information based on the lymph node image information; a control module for acquiring stimulation information based on the lymph node distribution information, wherein the stimulation information includes electrical stimulation selection; and a stimulation module for performing stimulation operations based on the stimulation information.
  • the lymph node regulation system further includes an information feedback module that collects user feedback information and transmits it to the data processing module.
  • the information feedback module includes an electrophysiological monitoring unit to measure human body impedance during the stimulation operation.
  • the data processing module includes: an image data processing unit, which processes the lymph node image information; a feedback information processing unit, which processes the user feedback information; and a data integration unit, which integrates the information of the image data processing unit and the feedback information processing unit, and outputs data to the control module.
  • the image data processing unit performs image segmentation on the lymph node image information to obtain the position, size, shape and number of the lymph nodes.
  • the electrical stimulation comprises direct current stimulation.
  • the stimulation information further includes stimulation intensity, stimulation duration, stimulation frequency, stimulation cycle and/or temperature.
  • the stimulation intensity ranges from 1-3.5 mA.
  • control module includes a condition information processing unit, which identifies the user category through the user condition information, and outputs the stimulation information to the stimulation module according to the mapping relationship between the user category and the stimulation information.
  • a second aspect of the present invention is a lymph node regulation method, comprising: collecting lymph node image information; obtaining lymph node distribution information based on the lymph node image information; obtaining stimulation information based on the lymph node distribution information, the stimulation information including electrical stimulation selection; and performing stimulation operations based on the stimulation information.
  • the present invention has the following beneficial effects:
  • the lymph node regulation system and method provided by the present invention utilizes electrical stimulation therapy to regulate superficial lymph nodes throughout the body, thereby promoting lymph flow and improving circulation while enhancing the activity and function of lymphocytes and promoting the work of the immune system.
  • the electrical stimulation device such as the electrical stimulation patch used in the lymph node regulation system provided by the present invention is relatively simple, has low manufacturing cost, and is easy to use, which makes the system applicable to a wider range of scenarios and provides a new idea for the development of lymph node regulation towards portability.
  • the lymph node regulation system provided by the present invention adopts an electrical stimulation device with adjustable parameters, which can perform safer and more comfortable stimulation according to individual needs and improve the individual adaptability of the system.
  • the lymph node regulation system provided by the present invention is provided with a detection module and a data processing module.
  • a detection module By collecting lymph node image information and performing image segmentation and other algorithm processing, distribution information with data such as lymph node location, size, and dimensions is obtained, thereby improving the targeting, accuracy, and regulation effect of lymph node regulation.
  • the lymph node regulation system provided by the present invention is provided with a data integration unit in the data processing module, which integrates the lymph node distribution information and user feedback information to make the best decision, outputs the stimulation parameter information to the control module, and guides the execution of the subsequent stimulation module.
  • FIG1 is a structural diagram of a lymph node regulation system in an embodiment
  • FIG. 2 is a flow chart of a lymph node regulation method in an embodiment.
  • the lymph node stimulation area in the embodiments of the present application includes superficial lymph nodes throughout the body, that is, lymph nodes distributed in the superficial parts of the human body in the skin and subcutaneous tissue, which are mainly divided into the following three areas: first, the cervical lymph node group, including preauricular lymph nodes, postauricular lymph nodes, occipital lymph nodes, submandibular lymph nodes, submental lymph nodes, anterior cervical lymph nodes, posterior cervical lymph nodes and supraclavicular lymph nodes; second, the axillary lymph node group, including axillary apex lymph nodes, central lymph nodes, pectoral lymph nodes, subscapular lymph nodes and lateral lymph nodes; third, the inguinal lymph nodes located in the femoral triangle below the inguinal ligament, including the transverse group of the inguinal ligament and the longitudinal group of the inguinal ligament.
  • the cervical lymph node group including preauricular lymph nodes, postauricular lymph nodes, occipital lymph
  • the embodiment of the present application provides a lymph node regulation system and method based on the distribution characteristics of human lymph nodes.
  • the system and method achieve the regulation of superficial lymph nodes throughout the body by collecting and analyzing the distribution of lymph nodes in the target area, selecting appropriate stimulation parameters and performing stimulation operations.
  • Embodiment 1 is a diagrammatic representation of Embodiment 1:
  • this embodiment provides a lymph node regulation system, including a detection module, a data processing module, a control module, a stimulation module, an information feedback module and a power management module.
  • the detection module is used to obtain the image information of lymph node distribution and transmit the data to the data processing module.
  • the data processing module uses an algorithm to convert the data into various data of the lymph nodes, and converts them into appropriate stimulation parameters through the control module, and then produces a stimulation effect under the action of the stimulation module.
  • the information feedback module is an auxiliary module, which is used to feedback the user's subjective information and then fine-tune some stimulation parameters.
  • the power management module manages the power supply of the system to ensure the stable operation of the system.
  • the detection module in this embodiment uses ultrasound contrast imaging techniques such as B-mode ultrasound and color Doppler ultrasound to collect the image data of superficial lymph nodes throughout the body.
  • data can also be obtained through methods such as electronic computer tomography and magnetic resonance imaging.
  • this module improves the accuracy of stimulating the target area, and on the other hand, it has good controllability and can flexibly control various parameters according to the target area, so that the system has higher safety and better stimulation effect.
  • the information feedback module can complete information feedback based on the subjective information of the user asked by professionals, such as stimulation intensity, heat, and whether there is discomfort and other somatic sensations, in conjunction with the human-computer interaction interface.
  • this embodiment is also provided with an electrophysiological monitoring unit and a body temperature monitoring unit, and closed-loop information feedback is achieved with the help of modern medical means.
  • the electrophysiological monitoring unit is specifically a biodielectric spectrum patch, a conventional 12-lead electrocardiogram, etc., which is used to measure the human body impedance during electrical stimulation in real time, so as to feed back information to the data processing module to determine whether the detection current is too large.
  • parameters such as heart rate, blood oxygen and blood oxygen saturation can also be calculated based on the electrocardiogram, electromyography, body temperature and other data fed back by the two monitoring units.
  • the user feedback information collected by the information feedback module is transmitted to the data processing module and the control module. On the one hand, it can be displayed through display devices such as display screens to timely understand the user's physiological state.
  • the stimulation parameters can be adjusted in real time according to the feedback parameters to improve the stimulation effect and achieve personalized stimulation.
  • the data processing module receives information from the detection module and the information feedback module and performs calculations and integration, and then transmits data to the control module.
  • the module includes an image data processing unit, a feedback information processing unit, and a data integration unit.
  • the image data processing unit uses the acquired lymph node image information to calculate and analyze the location, size, shape, number, blood flow and other information of the lymph nodes through image processing algorithms such as preprocessing and image segmentation of the microprocessor;
  • the feedback information processing unit uses the microcontroller to process and analyze according to the content of user feedback, and then obtains somatosensory information;
  • the data integration unit analyzes the information of the image data processing unit and the feedback information processing unit and integrates it to form a three-dimensional stimulation navigation image, and then adjusts the control module.
  • a human-computer interaction interface can also be set to visualize the data results of the image data processing unit and the data integration unit to display the location, size, shape, number and other information of the user's lymph nodes, and then manually intervene in the data processing method.
  • the data processing module can specifically include one or more terminal devices.
  • the control module is the main control module of the system, which is used to receive information from the data processing module to adjust the stimulation parameters, and transmit the data to the stimulation module to realize the regulation of the superficial lymph nodes of the whole body by the physical field.
  • the control module can specifically include one or more terminal devices, and can also use one or more terminal devices together with the data processing module.
  • control module includes a microprocessor, an electrical control unit, a human-computer interaction interface, etc., wherein the microprocessor controls the parameters of the electrical stimulation, such as stimulation intensity, stimulation duration, stimulation frequency, stimulation cycle, temperature, etc., according to the instructions output by the data processing module.
  • This embodiment uses 24V direct current, and the stimulation intensity, that is, the current value can be adjusted to 1-3.5mA, wherein 1mA stimulation has the best human adaptability.
  • the safety of the device is not only related to the stimulation intensity, but also depends on the stimulation duration, that is, the power-on time, which is generally controlled at about 20 minutes/time.
  • the stimulation intensity and stimulation duration should be adjusted in combination with the user's own situation, and the device should also be avoided in a humid environment.
  • control module can also be set up with other modal control units such as light control unit and ultrasound control unit, and then perform light stimulation and ultrasound stimulation in the subsequent stimulation module to assist in regulation.
  • the human-computer interaction interface set up by the control module includes a system display screen, a system power button, a current adjustment knob and a control button to undertake input functions such as input feedback information, and then manually intervene in each control unit, including mode selection and parameter setting.
  • control module may also be provided with a disease information processing unit, which collects the user's diagnosis report, medical history, physical examination report and other disease data and lymph node information through an artificial interactive interface, and analyzes and processes them to determine the category to which the user belongs, and then realizes automatic selection of stimulation parameters based on the mapping relationship between the user category and the stimulation, and guides the execution of subsequent stimulation modules.
  • the mapping relationship between the user category and the stimulation parameter can be manually pre-set, or it can be determined after big data analysis of a large amount of disease data.
  • the weights of each data in the user's disease information may be different, and some data items that have a greater impact on health or safety have a greater weight. For example, if a user is allergic to high-frequency electrical stimulation, the corresponding stimulation frequency for the user can only be low-frequency.
  • the stimulation module is used to generate non-invasive physical stimulation, and its target area is the superficial lymph nodes of the whole body.
  • an electrical stimulation device can be used.
  • other stimulation modalities can also be used for stimulation. At this time, different modes of stimulation can be performed separately, alternately, or simultaneously.
  • the stimulation module can be a wearable stimulation device of any shape, such as a semi-enclosed cylindrical flexible shell, etc., to improve the user's comfort and experience during the regulation process.
  • the stimulation electrode jack with positive and negative poles, the electrode head with a plug wire and an elastic fabric layer can be assembled in a flexible shell connected to the control module to generate direct current stimulation and have wearable characteristics.
  • an electrical stimulation patch can also be set to perform the stimulation operation.
  • the electric current generated by the electrical stimulation device enters the human body through the skin and sweat gland ducts, and while spreading along the lymphatic and blood vessels, it acts on many receptors on the wall of the tube and affects local operation through nerve reflexes.
  • the electric current causes the capillaries to expand and enhances the permeability of the tube wall, improving the blood exchange and nutrition of tissue cells.
  • the blood vessels initially show a short-term spasm, and then begin to expand, and in the process, the blood flow rate is accelerated.
  • the expansion and relaxation caused by this low-frequency current can also improve the elasticity of the vascular wall, thereby accelerating the exchange with the tissue fluid and promoting lymphatic return.
  • the electric current causes the muscles to contract rhythmically, which squeezes and empties the substances in the veins and lymphatic vessels, producing a "pump" effect to promote venous blood and lymphatic return.
  • the use of electric current stimulation on human lymph nodes can improve microcirculation and promote blood and lymphatic return.
  • this method of using electrical stimulation to regulate lymph nodes has the characteristics of adjustable range of stimulation source, small size, and simple device. On the one hand, it improves the targeting of stimulation to the action area and improves the accuracy of lymph node regulation. On the other hand, it reduces manufacturing costs and improves ease of use, making the system have a wider range of applicable scenarios and showing the potential for development into a portable device.
  • Embodiment 2 is a diagrammatic representation of Embodiment 1:
  • this embodiment provides a lymph node regulation method, which is executed by the above-mentioned lymph node regulation system, including S1, collecting lymph node image information; S2, obtaining lymph node distribution information based on the lymph node image information; S3, obtaining stimulation information such as electrical stimulation selection based on the lymph node distribution information; S4, performing stimulation operations based on the stimulation information.
  • S1. collecting lymph node image information refers to obtaining the image data of superficial lymph nodes throughout the body using ultrasound contrast imaging technology, electronic computer tomography, magnetic resonance imaging technology, etc.
  • Acquiring lymph node distribution information based on lymph node image information refers to using the acquired lymph node image information to calculate and analyze various information such as the location, size, shape, number, blood flow, etc. of the lymph nodes through an image processing algorithm of a microprocessor.
  • Acquiring stimulation information according to lymph node distribution information refers to selecting appropriate stimulation parameters using the acquired location information, which may be stimulation intensity, stimulation duration, stimulation frequency, stimulation cycle, temperature, and other parameters.
  • Executing stimulation operation according to stimulation information refers to using radio waves to produce non-invasive physical stimulation to the target area, and specific targets include superficial lymph nodes throughout the body.
  • the lymph node regulation method may also include S5, obtaining feedback parameters and adjusting the stimulation information in a closed loop according to the feedback parameters, specifically, obtaining feedback indicators and then adjusting the stimulation parameters by collecting user subjective reactions or monitoring user information using electrophysiological technology.
  • the present invention provides a lymph node regulation system and method, which utilizes non-invasive external electrical stimulation to regulate the superficial lymph nodes throughout the body, promotes the work of the immune system, and improves the individual's health level.
  • a lymph node regulation system and method which utilizes non-invasive external electrical stimulation to regulate the superficial lymph nodes throughout the body, promotes the work of the immune system, and improves the individual's health level.
  • the accuracy of lymph node regulation is improved, the cost of use is reduced, and the scope of application of the system is expanded.

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Abstract

一种淋巴结调控系统及方法。系统包括检测模块、数据处理模块、控制模块以及刺激模块，其中刺激模块利用直流电的无创外部刺激调控全身浅层淋巴结，促进了免疫系统的工作。此外，利用电刺激作用范围易控制、设备简单的特点，提高了淋巴调控的精确度，降低了使用成本，扩大了系统适用范围。

Description

一种淋巴结调控系统及方法 技术领域
本发明涉及医疗技术领域，具体涉及一种淋巴结调控系统及方法。
 背景技术
淋巴循环作为血液循环的辅助系统，一方面可以调节血浆与组织液之间的平衡，带走一部分代谢产物，另一方面还可以把少量由血管透出的蛋白质类物质再运回血液中，使得这类大分子物质不易再透入毛细血管，从而改善了微循环。
解剖学中，用于执行淋巴循环的淋巴系统具体包括淋巴管道、淋巴组织和淋巴器官，其中淋巴器官由淋巴结、胸腺、脾脏和扁桃体等组成。作为淋巴系统的重要组成部分，淋巴结不仅分布在全身的淋巴通道上，还在内腔器官附近沿血管排列。这一重要的免疫组织器官既是淋巴液流经汇聚过滤的地方，也是T淋巴细胞和B淋巴细胞留居繁殖的场所，更是免疫应答发生的重要基地。通过外界作用刺激淋巴结可以促进血液及淋巴液循环，增强吞噬细胞的吞噬功能，提高人体免疫力，促进病体康复，进而起到扶正祛邪的作用。
因而，人们设计了一系列通过外界作用刺激淋巴结的方法或产品，比如针灸电热刺激疗法。该方法利用粗细为25或26号、长度为4-6寸的毫针穿透患者淋巴结，并加以EC-I电疗仪使患者有温热胀感。被刺激的淋巴结通常位于待治疗部位临近区域，如上肢、胸部的治疗选择腋下淋巴结、下肢、腹部的治疗选择腹股沟淋巴结、头部的治疗选择耳后淋巴结等，留针时间通常为30-40分钟，每日一次，并以12次作为一个疗程，实现了调控淋巴结的目的。但是，该方法也存在较为明显的不足：一方面，执行该方法需要刺破皮肤，可能会引起使用者的不适，或是增加感染风险；另一方面，入针的深浅不易精确控制，空间分辨率较低，无法准确刺激目标区域，进而影响作用效果。
针对以上容易引起人员不适、空间分辨率低等问题，研究者开发了利用物理场调控淋巴结的技术，主要包括光刺激、超声刺激等。该技术的优势一方面在于，刺激能够直接作用于靶点细胞，并且可以通过调节参数实现细胞活动的精确控制；另一方面在于，该技术具有非侵入性、可重复性和可调节性等特点，避免了传统手术等治疗方法可能带来的潜在风险和不良影响。因而，将物理场调控技术应用于淋巴结调控的场景，不仅可以提高使用者的适应性，在更加安全和舒适的手段下完成调节，还可以提高刺激参数的可调性，达到更高的时空分辨率和精准的刺激效果。
 技术问题
目前，研究人员利用光刺激和超声刺激实现了脑颈部淋巴结的物理场调控，但这类方法的适应场景较为狭窄，不能满足现有需求，亟待解决。本方案优势：采用电刺激有可以更精准的刺激相应部位、刺激效果更好、使用者体验感会更好。
 技术解决方案
本发明的目的在于克服现有技术不足，解决上述背景技术中的至少一种缺陷。
为实现上述目的，本发明提供以下技术方案：
本发明的第一方面，提供一种淋巴结调控系统，包括：检测模块，采集淋巴结影像信息；数据处理模块，根据所述淋巴结影像信息获取淋巴结分布信息；控制模块，根据所述淋巴结分布信息获取刺激信息，所述刺激信息包括电刺激选择；以及刺激模块，根据所述刺激信息执行刺激操作。
在一些实施例中，淋巴结调控系统还包括信息反馈模块，采集用户反馈信息并传输至所述数据处理模块。
在一些实施例中，所述信息反馈模块包括电生理监测单元，测量所述刺激操作中的人体阻抗。
在一些实施例中，所述数据处理模块包括：影像数据处理单元，处理所述淋巴结影像信息；反馈信息处理单元，处理所述用户反馈信息；以及数据整合单元，整合所述影像数据处理单元、所述反馈信息处理单元的信息，并向所述控制模块输出数据。
在一些实施例中，所述影像数据处理单元对所述淋巴结影像信息进行图像分割，获取淋巴结的位置、尺寸、形状和数量。
在一些实施例中，所述电刺激包括直流电刺激。
在一些实施例中，所述刺激信息还包括刺激强度、刺激持续时间、刺激频率、刺激周期和/或温度。
在一些实施例中，所述刺激强度的范围为1-3.5mA。
在一些实施例中，所述控制模块包括病情信息处理单元，通过用户病情信息识别用户类别，并根据所述用户类别与所述刺激信息之间的映射关系，向所述刺激模块输出所述刺激信息。
本发明的第二方面，一种淋巴结调控方法，包括：采集淋巴结影像信息；根据所述淋巴结影像信息获取淋巴结分布信息；根据所述淋巴结分布信息获取刺激信息，所述刺激信息包括电刺激选择；以及根据所述刺激信息执行刺激操作。
 有益效果
与现有技术相比，本发明的有益效果是，
（1）本发明所提供的淋巴结调控系统及方法利用电刺激疗法调控全身浅层淋巴结，在促进淋巴流动、改善循环的同时，增强了淋巴细胞的活性和功能，促进了免疫系统工作。
（2）本发明所提供的淋巴结调控系统采用的电刺激贴片等电刺激装置较为简单，制造成本低，使用简便，使得系统具有更广的适用场景，为淋巴结调控朝便携式发展提供了新思路。
（3）本发明所提供的淋巴结调控系统采用了参数可调的电刺激装置，可以根据个体需求差异执行更为安全、舒适的刺激，也提高了系统的个体适应性。
（4）本发明所提供的淋巴结调控系统设置有检测模块和数据处理模块，通过采集淋巴结影像信息并对其进行图像分割等算法处理得到具有淋巴结位置、大小、尺寸等数据的分布信息，进而提高淋巴结调控的靶向性、精确度以及调控效果。
（5）本发明所提供的淋巴结调控系统在数据处理模块设置有数据整合单元，该单元对淋巴结分布信息和用户反馈信息进行整合，以作出最优决策，向控制模块输出刺激参数信息，指导后续刺激模块的执行。
 附图说明
图1为一种实施例中的淋巴结调控系统结构图；
图2为一种实施例中的淋巴结调控方法流程图。
 本发明的实施方式
下面将结合具体实施方式对本专利的技术方案作进一步详细地说明，应该指出，以下详细说明都是示例性的，旨在对本申请提供进一步的说明。除非另有指明，本文使用的所有技术和科学术语具有与本申请所属技术领域的普通技术人员通常理解的相同含义。
本申请实施例中的淋巴结刺激区域包括全身浅层淋巴结，即分布于皮肤和皮下组织的人体表浅部位的淋巴结，主要分为以下三个区域：其一，颈部淋巴结组群，包括耳前淋巴结、耳后淋巴结、枕淋巴结、颌下淋巴结、颏下淋巴结、颈前淋巴结、颈后淋巴结以及锁骨上淋巴结等；其二，腋下淋巴结组群，包括腋尖淋巴结、中央淋巴结、胸肌淋巴结、肩胛下淋巴结以及外侧淋巴结等；其三，位于腹股沟韧带下方股三角内的腹股沟淋巴结，包括腹股沟韧带横组和腹股沟韧带纵组。
本申请实施例基于人体淋巴结分布特点，提供一种淋巴结调控系统及方法。该系统及方法通过采集并分析目标区域的淋巴结分布情况，选择合适的刺激参数并执行刺激操作，实现了全身浅层淋巴结的调控。
实施例1：
如图1所示，本实施例提供一种淋巴结调控系统，包括检测模块、数据处理模块、控制模块、刺激模块、信息反馈模块和电源管理模块。
其中，检测模块用于获取淋巴结分布的影像信息并将数据传输到数据处理模块，数据处理模块使用算法将数据转化为淋巴结的各项数据，并通过控制模块转化为适当的刺激参数，进而在刺激模块的作用下产生刺激效果。信息反馈模块为辅助模块，用于反馈用户主观信息，进而对部分刺激参数进行微调，电源管理模块则对系统的电源进行管理，以保证系统的稳定运行。
具体地，本实施例中的检测模块采用了B型超声、彩色多普勒超声等超声造影成像技术进行检测，以采集全身浅层淋巴结影像数据，此外也可以通过电子计算机断层扫描、核磁共振成像技术等方法获取数据。该模块一方面提高了刺激靶向目标区域的精确性，另一方面具有良好的可控制性，可以根据目标区域灵活控制各项参数，使得系统具有更高的安全性和更好的刺激效果。
信息反馈模块可以基于专业人员在旁询问的用户主观信息，如刺激强度、热量以及是否存在不适等体感，配合人机交互界面完成信息反馈。但完全依靠用户主观感受可能出现误判的情况，因此本实施例还设置有电生理监测单元和体温监测单元，借助现代医学手段实现了闭环信息反馈。电生理监测单元具体为生物介电谱贴片、常规12导联心电图等，用于实时测量电刺激过程中的人体阻抗，从而将信息反馈至数据处理模块以判断检测电流是否过大。此外，基于两监测单元所反馈的心电、肌电、体温等数据还可计算出心率、血氧和血氧饱和度等参数。将信息反馈模块采集的用户反馈信息传输至数据处理模块、控制模块，一方面可以通过显示屏等显示设备进行显示，及时了解用户的生理状态，另一方面可以根据反馈参数实时调整刺激参数，提高刺激效果，实现个性化刺激。
数据处理模块接收检测模块和信息反馈模块的信息并进行计算整合，进而向控制模块传输数据。该模块包括影像数据处理单元、反馈信息处理单元以及数据整合单元。其中，影像数据处理单元利用获取的淋巴结影像信息，通过微处理器的预处理、图像分割等图像处理算法计算分析出淋巴结的位置、尺寸、形状、数量、血流等各项信息；反馈信息处理单元根据用户反馈的内容，利用微控制器处理分析，进而得到体感等信息；数据整合单元分析影像数据处理单元和反馈信息处理单元的信息并进行整合，形成三维刺激导航图像，进而调整控制模块。此外，还可以设置人机交互界面，将影像数据处理单元和数据整合单元的数据结果可视化，以展示用户淋巴结的位置、尺寸、形状、数量等信息，进而人为干预数据处理方式。与此同时，数据处理模块具体可以包括一台或多台终端设备。
控制模块是系统的主控模块，用于接收数据处理模块的信息以调节刺激参数，并将数据传递到刺激模块实现物理场对全身浅层淋巴结的调控。控制模块具体可以包括一台或多台终端设备，也可以与数据处理模块共同利用一台或多台终端设备。
此外，控制模块包括微处理器、电控制单元、人机交互界面等，其中微处理器根据数据处理模块输出的指令控制电刺激的参数，如刺激强度、刺激持续时间、刺激频率、刺激周期、温度等。本实施例采用了24V的直流电，刺激强度即可调节电流数值为1-3.5mA，其中1mA刺激所具有的人体适应性最好。就流经人体的电流通路而言，设备安全性不仅与刺激强度有关，还取决于刺激持续时间即通电时间，一般控制在20分钟/次左右，使用时应结合用户自身情况调节刺激强度和刺激持续时间，还应避免在潮湿环境下使用本设备。
与此同时，控制模块还可设置光控制单元、超声控制单元等其他模态控制单元，进而在后续刺激模块执行光刺激、超声刺激以辅助调控。控制模块设置的人机交互界面包括系统显示屏、系统电源键、电流调节旋钮以及控制按键，以承担输入反馈信息等输入功能，进而对各控制单元进行人工干预，干预内容包括模态选择和参数设定等。
进一步地，控制模块还可设置病情信息处理单元，该单元通过人工交互界面收集用户的诊断报告、病历和体检报告等病情数据和淋巴结信息，并对其进行分析处理，确定用户所属类别，进而根据用户类别和刺激之间的映射关系，实现刺激参数的自动选择，指导后续刺激模块的执行。其中，用户类别与刺激参数之间的映射关系可以是人为预先设定的，也可以是通过对大量病情数据进行大数据分析后确定的。需要说明的是，用户病情信息中的各项数据的权重可以不一样，一些对健康或安全影响较大的数据项的权重较大，例如，某个用户对高频电刺激过敏，则该用户对应的刺激频率只能是低频。
刺激模块用于产生非侵入式物理刺激，其靶点区域为全身浅层淋巴结，具体可采用电刺激装置。除电刺激外也可采用其他刺激模态进行刺激，此时不同方式的刺激可以单独进行，也可以交替进行或同时进行。
刺激模块具体可以是形状任意的可穿戴式刺激装置，如半包围圆柱状的柔性外壳等，以提高调控过程中用户的舒适度和体验度。具体应用时，可将具有正负极的刺激电极插孔、带插头导线和附加有弹性织物层的电极头等装配在与控制模块相连接的柔性外壳中，使其产生直流电刺激并具备可穿戴的特点。此外，也可设置电刺激贴片执行刺激操作。
由电刺激装置产生的电流经皮肤、汗腺管进入人体，在沿淋巴管和血管扩散同时，作用于管壁上的众多感受器并经神经反射影响局部运作。一方面，电流使毛细血管发生扩张并增强了管壁的通透性，改善了组织细胞的血液交流和营养。具体来讲，当电流对血管产生作用时，血管最初表现为短时间的痉挛，继而开始扩张，并在此过程中加快了血液流速，同时，这种低频电流引起的扩张、舒张还可以改善血管壁的肌理弹性，从而加快与组织液之间进行交换的速度，促进淋巴回流。另一方面，电流使肌肉发生节律性收缩，进而挤压排空静脉和淋巴管内的物质，产生“泵”的作用，以促进静脉血液和淋巴回流。综上，利用电流刺激作用于人体淋巴结，可以改善微循环，促进血液和淋巴回流。
此外，这种利用电刺激进行淋巴结调控的方式具有刺激源作用范围可调、体积较小、装置简单等特点，一方面提高了刺激对作用区域的靶向性，提升了淋巴结调控的精确度，另一方面降低了制造成本，提高了使用便捷性，使得系统具有更广的适用场景，展现出了朝向便携式设备发展的潜力。
实施例2：
如图2所示，本实施例提供一种淋巴结调控方法，该方法由上述淋巴结调控系统执行，包括S1、采集淋巴结影像信息；S2、根据淋巴结影像信息获取淋巴结分布信息；S3、根据淋巴结分布信息获取电刺激选择等刺激信息；S4、根据刺激信息执行刺激操作。
具体地，S1、采集淋巴结影像信息是指利用超声造影成像技术、电子计算机断层扫描、核磁共振成像技术等获取全身浅层淋巴结影像数据。
S2、根据淋巴结影像信息获取淋巴结分布信息是指利用获取的淋巴结影像信息，通过微处理器的图像处理算法计算分析出淋巴结的位置、尺寸、形状、数量、血流等各项信息。
S3、根据淋巴结分布信息获取刺激信息是指利用获取的位置信息选择合适的刺激参数。具体可以为刺激强度、刺激持续时间、刺激频率、刺激周期、温度等参数选择。
S4、根据刺激信息执行刺激操作是指利用电波对目标区域产生非侵入式的物理刺激，具体靶点包括全身浅层淋巴结。
进一步地，淋巴结调控方法还可以包括S5、获取反馈参数并根据反馈参数闭环调节刺激信息，具体是指通过采集用户主观反应或是利用电生理技术监测用户信息，获得反馈指标进而调节刺激参数。
综上所述，本发明提供一种淋巴结调控系统及方法，利用电刺激的无创外部刺激调控全身浅层淋巴结，促进了免疫系统的工作，改善了个体健康水平。此外，利用电刺激作用范围易控制、设备简单的特点，提高了淋巴调控的精确度，降低了使用成本，扩大了系统适用范围。
以上所述仅是本发明的一些实施方式。对于本领域技术人员来说，在不脱离本发明创造构思的前提下，还可以做出若干变形和改进，这些都属于本发明的保护范围。

Claims (10)

  1. 一种淋巴结调控系统，其特征在于，包括：
    检测模块，采集淋巴结影像信息；
    数据处理模块，根据所述淋巴结影像信息获取淋巴结分布信息；
    控制模块，根据所述淋巴结分布信息获取刺激信息，所述刺激信息包括电刺激选择；以及
    刺激模块，根据所述刺激信息执行刺激操作。
  2. 根据权利要求1所述的淋巴结调控系统，其特征在于，还包括：
    信息反馈模块，采集用户反馈信息并传输至所述数据处理模块。
  3. 根据权利要求2所述的淋巴结调控系统，其特征在于，所述信息反馈模块包括：
    电生理监测单元，测量所述刺激操作中的人体阻抗。
  4. 根据权利要求3所述的淋巴结调控系统，其特征在于，所述数据处理模块包括：
    影像数据处理单元，处理所述淋巴结影像信息；
    反馈信息处理单元，处理所述用户反馈信息；以及
    数据整合单元，整合所述影像数据处理单元、所述反馈信息处理单元的信息，并向所述控制模块输出数据。
  5. 根据权利要求4所述的淋巴结调控系统，其特征在于，所述影像数据处理单元对所述淋巴结影像信息进行图像分割，获取淋巴结的位置、尺寸、形状和数量。
  6. 根据权利要求1-5中任一项所述的淋巴结调控系统，其特征在于，所述电刺激包括直流电刺激。
  7. 根据权利要求6所述的淋巴结调控系统，其特征在于，所述刺激信息还包括：
    刺激强度、刺激持续时间、刺激频率、刺激周期和/或温度。
  8. 根据权利要求7所述的淋巴结调控系统，其特征在于，所述刺激强度为1-3.5mA。
  9. 根据权利要求8所述的淋巴结调控系统，其特征在于，所述控制模块包括：
    病情信息处理单元，通过用户病情信息识别用户类别，并根据所述用户类别与所述刺激信息之间的映射关系，向所述刺激模块输出所述刺激信息。
  10. 一种淋巴结调控方法，其特征在于，包括：
    采集淋巴结影像信息；
    根据所述淋巴结影像信息获取淋巴结分布信息；
    根据所述淋巴结分布信息获取刺激信息，所述刺激信息包括电刺激选择；以及
    根据所述刺激信息执行刺激操作。
PCT/CN2023/137647 2023-05-19 2023-12-08 一种淋巴结调控系统及方法 Ceased WO2024239607A1 (zh)

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