WO2024130577A1 - 动物生命体征实时监测系统 - Google Patents

动物生命体征实时监测系统 Download PDF

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Publication number
WO2024130577A1
WO2024130577A1 PCT/CN2022/140572 CN2022140572W WO2024130577A1 WO 2024130577 A1 WO2024130577 A1 WO 2024130577A1 CN 2022140572 W CN2022140572 W CN 2022140572W WO 2024130577 A1 WO2024130577 A1 WO 2024130577A1
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animal
physiological information
real
time monitoring
acquisition sensor
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French (fr)
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王琳
张一栏
王烨
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Shenzhen Institute of Advanced Technology of CAS
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Shenzhen Institute of Advanced Technology of CAS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition

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  • the present application relates to the technical field of laboratory animal vital sign monitoring, and in particular to a real-time monitoring system for animal vital signs.
  • the existing small animal wearable fabrics have a relatively simple function, usually used to fix small animals for acupuncture and other operations.
  • Devices for monitoring the physiological information of small animals are generally complex, cannot be worn, and have few measurement parameters.
  • implantable small animal physiological information monitoring technologies There are implantable small animal physiological information monitoring technologies, but they will interfere with the normal physiological information of small animals.
  • fixation clothes for mouse fixation and acupuncture there are similar invention patents such as fixation clothes for mouse fixation and acupuncture.
  • the patent application number 201420853966.5 “Fixation clothes and fixation device for experimental mice” proposes a mouse fixation clothes and fixation device used in medical animal experiments; the patent application number 201320727782.
  • “Mouse abdominal and dorsal acupuncture fixator” proposes a mouse abdominal and dorsal acupuncture fixator that can perform acupuncture on the back and abdomen of mice at the same time;
  • the patent application number 200510019571.0 “Mouse asthma model vital signs monitoring device” realizes the accurate measurement and analysis of the vital signs of mouse asthma model, which is suitable for the basic research on the cause and pathogenesis of asthma.
  • the measurement parameters of these devices are relatively single.
  • Patent application number 201920519555.5 "A monitoring device for detecting the vital signs of mice”, uses millimeter-wave radar and digital signal modules to analyze and process the heart rate and respiratory rate of mice, but the accuracy is not high;
  • Patent application number 202111134089.7 "A laboratory anesthesia information processing system and method based on big data”, collects corresponding data through electrocardiogram acquisition modules, blood pressure acquisition modules, and blood oxygen saturation acquisition modules, and processes anesthesia information by adjusting the concentration of anesthetic drugs.
  • the system device and operation are relatively complicated.
  • the above inventions for in vitro physiological information monitoring of mice have relatively simple measurement parameters and complex systems. At present, there are some small animal vital signs monitoring devices implanted in the body on the market, but they cause great damage to mice and affect normal physiological information parameters.
  • One of the purposes of the present application is to provide a real-time monitoring system for animal vital signs, comprising: a signal acquisition sensor, a wearable fabric and a signal analysis platform, wherein the signal acquisition sensor is used to detect physiological information parameters, the signal acquisition sensor is fixed on the wearable fabric, and the signal analysis platform is used to obtain the physiological information parameters and analyze the physiological information parameters, wherein the physiological information parameters include animal heart rate, respiratory rate, body temperature, blood oxygen saturation and number of exercise steps.
  • the information acquisition sensor is connected to the embedded main control STM32F103C8T6, and receives the physiological information parameters using a Bluetooth gateway through a broadcast protocol, and transmits the physiological information parameters to the signal analysis platform.
  • the signal analysis platform obtains the animal's heart rate, respiratory rate, body temperature, blood oxygen saturation and exercise steps based on the physiological information parameters.
  • the signal acquisition sensor includes a PPG green light module, and the PPG green light module obtains dynamic heart rate parameters according to photoplethysmography.
  • the signal analysis platform performs time domain analysis on the dynamic heart rate parameters to calculate the heart rate value.
  • the signal acquisition sensor includes a PPG red light and infrared light module.
  • the PPG red light and infrared light module obtains the blood oxygen saturation parameter according to the different absorption characteristics of oxygenated hemoglobin HbO2 and hemoglobin Hb contained in the blood to light of different wavelengths, and the signal analysis platform calculates the corresponding ratio according to the blood oxygen saturation parameter to obtain the blood oxygen value.
  • the signal acquisition sensor includes a high thermal conductivity temperature sensor, which can continuously measure the animal's body surface temperature, and the signal analysis platform calculates the body temperature through a built-in algorithm based on the body surface temperature.
  • the signal acquisition sensor includes an accelerometer, using the a x , a y , and a z parameters of the three-axis accelerometer, and the signal analysis platform obtains the signal through median filtering and peak detection.
  • the signal analysis platform obtains the respiratory rate based on the heart rate value.
  • the wearable fabric is made of elastic woven fabric, and a fixed pocket for fixing the signal acquisition sensor is provided at a position of the wearable fabric close to the heart of the animal.
  • the animal vital signs real-time monitoring system comprises: a signal acquisition sensor, a wearable fabric and a signal analysis platform, wherein the signal acquisition sensor is used to detect physiological information parameters, the signal acquisition sensor is fixed on the wearable fabric, and the signal analysis platform is used to obtain the physiological information parameters and analyze the physiological information parameters, wherein the physiological information parameters include the animal's heart rate, respiratory rate, body temperature, blood oxygen saturation and number of steps.
  • the animal vital signs real-time monitoring system overcomes the defects of the existing animal physiological information monitoring devices, such as complex systems, inability to wear, single measurement parameters, and need for in vivo implantation, and realizes real-time monitoring of the heart rate, respiratory rate, body temperature, blood oxygen and other physiological information of the small animal during exercise without interfering with the normal life activities of the small animal. It can monitor and remotely record the changes in the vital signs data of mice in real time and obtain better data results.
  • FIG1 is a schematic diagram of the structure of a real-time monitoring system for animal vital signs provided in an embodiment of the present application.
  • FIG2 is a schematic diagram of the structure of a wearable fabric provided in an embodiment of the present application.
  • FIG3 is a schematic diagram of a configuration page of the information analysis platform provided in Example 1 of the present application.
  • FIG4 is a schematic diagram of a system overview page of the information analysis platform provided in Example 1 of the present application.
  • FIG5 is a diagram showing the effect after the experiment provided in Example 1 of the present application.
  • first and second are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, a feature defined as “first” or “second” may explicitly or implicitly include one or more of the features. In the description of this application, the meaning of “plurality” is two or more, unless otherwise clearly and specifically defined.
  • Fig. 1 is a schematic diagram of the structure of a real-time monitoring system for animal vital signs provided by an embodiment of the present application, including: a signal acquisition sensor 110, a wearable fabric 120 and a signal analysis platform 130.
  • a signal acquisition sensor 110 a wearable fabric 120
  • a signal analysis platform 130 a signal analysis platform 130.
  • the signal acquisition sensor 110 is used to detect physiological information parameters, including animal heart rate, respiratory rate, body temperature, blood oxygen saturation and movement steps.
  • the information acquisition sensor 110 is connected to the embedded main control STM32F103C8T6, and receives the physiological information parameters using a Bluetooth gateway through a broadcast protocol, and transmits the physiological information parameters to the signal analysis platform.
  • the signal analysis platform obtains the animal's heart rate, respiratory rate, body temperature, blood oxygen saturation and exercise steps based on the physiological information parameters.
  • the wearable fabric 120 is made of elastic woven fabric.
  • a fixing pocket for fixing the signal acquisition sensor 110 is provided at a position of the wearable fabric 120 close to the animal's heart.
  • the signal acquisition sensor 110 includes a PPG green light module, and the PPG green light module obtains dynamic heart rate parameters according to photoplethysmography.
  • the signal analysis platform performs time domain analysis on the dynamic heart rate parameters to calculate the heart rate value.
  • the signal acquisition sensor 110 includes a PPG red light and infrared light module.
  • the PPG red light and infrared light module obtains the blood oxygen saturation parameter according to the different absorption characteristics of oxygenated hemoglobin HbO2 and hemoglobin Hb contained in the blood to light of different wavelengths, and the signal analysis platform calculates the corresponding ratio according to the blood oxygen saturation parameter to obtain the blood oxygen value.
  • the signal acquisition sensor 110 includes a high thermal conductivity temperature sensor, which can continuously measure the animal's body surface temperature, and the signal analysis platform calculates the body temperature through a built-in algorithm based on the body surface temperature.
  • the signal acquisition sensor 110 includes an accelerometer and a gyroscope, using ax , ay , az of the accelerometer and mx , my , mz of the gyroscope, and the signal analysis platform 130 obtains the number of motion steps by using median filtering and peak detection.
  • the signal analysis platform 130 obtains the respiratory rate based on the heart rate value.
  • the real-time monitoring system for animal vital signs provided by the above-mentioned embodiment of the present application, the signal acquisition sensor 110 is used to detect physiological information parameters, the signal acquisition sensor 110 is fixed on the wearable fabric 120, and the signal analysis platform 130 is used to obtain the physiological information parameters and analyze the physiological information parameters, and the physiological information parameters include animal heart rate, respiratory rate, body temperature, blood oxygen saturation and movement steps.
  • the real-time monitoring system for animal vital signs provided by the present application overcomes the defects of the existing animal physiological information monitoring device, such as complex system, inability to wear, single measurement parameters, and need for in vivo implantation, and realizes real-time monitoring of the heart rate, respiratory rate, body temperature, blood oxygen and other physiological information of small animals during exercise without interfering with the normal life activities of small animals. It can monitor and remotely record the changes in the vital signs data of mice in real time, and obtain better data results.
  • mice 6-8 week old healthy white mice are suspended at 5° using the tail suspension method (with the hind limbs unloaded). The mice can grow and move normally.
  • the device consists of three parts: wearable fabric, signal acquisition sensor (mainly optical sensor) and physiological information acquisition and analysis system. (See Figure 1 and Figure 2)
  • the purpose of the wearable clothing is to fix the signal acquisition sensor, read the dynamic heart rate, respiratory rate, body temperature, blood oxygen saturation SPO2 and other data; and at the same time, the mouse can move freely. Therefore, the wearable clothing uses elastic fabric and the size is made according to the body size of the experimental mouse. Leave a hole for the mouse's forelimbs so that the mouse can move freely. In the position of the wearable clothing close to the mouse's heart, leave a fixed pocket for the sensor and a hole for detecting the signal so that the signal can be collected normally.
  • the information acquisition sensor is connected to the embedded main control. STM32F103C8T6, and uses the Bluetooth gateway to receive data through the broadcast protocol. The data is developed into our physiological information acquisition system platform, and the heart rate, respiratory rate, body temperature, blood oxygen saturation SPO2, etc. of the mouse are calculated through relevant algorithms.
  • the specific implementation method is as follows: the dynamic heart rate is measured by the PPG green light module with an accuracy of 5bpm, 10bpm and 15bpm, and the data is broadcast once every 250ms.
  • the power consumption is ultra-low and accurate, supporting broadcast protocol reading and SDK/API APP reading.
  • the photoplethysmography method due to the blood flow in the artery, the absorption of light changes, and the obtained signal is divided into a DC signal and an AC DC signal.
  • the heart rate value is calculated through time domain analysis.
  • a flexible signal acquisition device is designed with a size of 24mm long and 10mm wide.
  • Blood oxygen SPO2 is measured by PPG red light and infrared light modules, with high power consumption of about 800uA. Since oxygenated hemoglobin HbO2 and hemoglobin Hb contained in the blood have different absorption characteristics for light of different wavelengths, the signal analysis platform calculates the corresponding ratio through relevant algorithms to obtain the blood oxygen value.
  • the surface temperature is measured by a high thermal conductivity temperature sensor, which continuously measures the surface temperature of the mouse and broadcasts it continuously. The accuracy is ⁇ 0.1 degrees Celsius.
  • the signal analysis platform calculates the body temperature by combining the surface temperature with the built-in algorithm. The signal analysis platform calculates the respiratory rate in combination with the measured heart rate.
  • the number of steps is mainly obtained by using a x , a y , a z of the accelerometer and m x , my y , m z of the gyroscope, and by using median filtering and peak detection.
  • the sampling rate is 25 Hz.
  • the measured data is uploaded to the physiological information monitoring system via the Bluetooth connection protocol.
  • the first step is to configure the age and weight of the user (i.e., the mouse) and connect the sensor device, as shown in Figure 3, which is a schematic diagram of the configuration page of the information analysis platform provided in this embodiment.
  • the second step is to enter the system overview page and start collecting mouse physiological information, as shown in FIG4 , which is a schematic diagram of the system overview page provided in this embodiment.
  • the third step is to enter the detailed parameter page and observe the real-time data.
  • the heart rate, respiratory rate, and body surface temperature output results every 30 seconds to form a line graph; the blood oxygen output measurement results every 2 minutes and then draw a bar graph.
  • the experimental mouse vital signs monitoring is composed of a non-restrained wearable clothing, a sensor, an experimental mouse, a vital signs observation cabin, and an electronic computer. The experimental mouse is suspended.
  • FIG5 is a diagram showing the effect of the experiment in the embodiment of the present application.
  • the heart rate of the experimental mice can be accurately measured and recorded, and it can be seen that the result meets the expectations and requirements.
  • the results show that the present invention has designed a real-time monitoring system for animal vital signs, which can record parameters such as heart rate, respiratory rate, body temperature, blood oxygen saturation SPO2, etc. during the unrestrained movement of small animals, thereby facilitating the exploration of changes in relevant physiological information of small animals during normal life activities.

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Abstract

一种动物生命体征实时监测系统，包括：信号采集传感器（110）、可穿戴织物（120）及信号分析平台（130），所述信号采集传感器（110）用来检测生理信息参数，所述信号采集传感器（110）固定于所述可穿戴织物（120）上，所述信号分析平台（130）用于获取所述生理信息参数，并对所述生理信息参数进行分析，所述生理信息参数包括动物心率、呼吸频率、体温、血氧饱和度及运动步数。该动物生命体征实时监测系统，克服现有的动物生理信息监测装置的系统复杂、无法穿戴、测量参数单一、需要体内植入等缺陷，实现了在对小动物正常生命活动无干扰的情况下，实时监测小动物在运动过程中心率、呼吸频率、体温、血氧等生理信息，能够实时监测并远程记录小鼠生命体征数据变化。

Description

动物生命体征实时监测系统 技术领域
本申请涉及实验动物体征监测技术领域，特别涉及一种动物生命体征实时监测系统。
背景技术
现有的小动物穿戴织物功能较为单一，通常用来固定小动物以对其进行针刺等操作。针对小动物生理信息监测的装置，普遍设备复杂、无法穿戴且测量参数较少。有植入式的小动物生理信息监测技术，但是会对小动物的正常生理信息造成干扰。
目前已有的发明相近专利有用于小鼠固定及针刺的固定衣，申请号为201420853966.5的专利《实验小鼠的固定衣及固定装置》提出了一种在医学动物实验中使用的小鼠固定衣及固定装置；申请号为201320727782.X的专利《小鼠腹背针刺固定器》提出了一种小鼠腹背针刺固定器，可同时进行小鼠背部和腹部的针刺；申请号为200510019571.0的专利《小鼠哮喘模型体征监测装置》实现了对小鼠哮喘模型体征的精确测量与分析，适用于哮喘的病因及发病机理的基础研究。这些装置测量参数较为单一。申请号为201920519555.5的专利《一种用于探测小鼠生命体征的监测装置》使用毫米波雷达及数字信号模块，对小鼠的心率、呼吸速率进行分析处理，但是精度不高；申请号为202111134089.7的专利《一种基于大数据的实验室麻醉信息处理系统及方法》 通过心电图采集模块、血压采集模块和血氧饱和度采集模块等采集相应数据，通过调节麻醉药物浓度，对麻醉信息进行处理。但是该系统装置及操作都较为复杂。以上针对于小鼠的体外生理信息监测发明，测量参数都较为单一，且系统复杂。目前市面上还有一些体内植入的小动物生命体征监测装置，但是对小鼠损伤较大，且影响到正常的生理信息参数。
发明内容
鉴于此，有必要针对现有技术中存在的缺陷提供一种可实现动物正常生命活动无干扰的情况下，实时监测动物生理信息的动物生命体征实时监测系统。
为解决上述问题，本申请采用下述技术方案：
本申请的目的之一，提供了一种动物生命体征实时监测系统，包括：信号采集传感器、可穿戴织物及信号分析平台，所述信号采集传感器用来检测生理信息参数，所述信号采集传感器固定于所述可穿戴织物上，所述信号分析平台用于获取所述生理信息参数，并对所述生理信息参数进行分析，所述生理信息参数包括动物心率、呼吸频率、体温、血氧饱和度及运动步数。
在其中一些实施例中，所述信息采集传感器连接嵌入式主控STM32F103C8T6，并通过广播协议使用蓝牙网关接收所述生理信息参数，并将所述生理信息参数传输至所述信号分析平台，所述信号分析平台根据所述生理信息参数获取动物的心率、呼吸频率、体温、血氧饱和度及运动步数。
在其中一些实施例中，所述信号采集传感器包括PPG绿光模组，所述PPG 绿光模组根据光电容积脉搏波描记法获取动态心率参数，所述信号分析平台对所述动态心率参数进行时域分析，计算出心率值。
在其中一些实施例中，所述信号采集传感器包括PPG红光和红外光模组。所述PPG红光和红外光模组根据血液中含有的氧合血红蛋白HbO2和血红蛋白Hb对不同波长的光有不同的吸收特性，获取所述血氧饱和度参数，所述信号分析平台根据血氧饱和度参数计算出相应的比值，得到血氧值。
在其中一些实施例中，所述信号采集传感器包括高导热温度传感器，所述高导热温度传感器可连续测量动物体表温度，所述信号分析平台根据所述体表温度通过内置算法计算出体温。
在其中一些实施例中，所述信号采集传感器包含加速度计，采用三轴加速度计的a x，a y，a z参数，所述信号分析平台通过中值滤波及波峰检测获取
运动步数。
在其中一些实施例中，所述信号分析平台根据所述心率值，得到呼吸率。
在其中一些实施例中，所述可穿戴织物采用有弹性的织布，在所述可穿戴织物靠近动物心脏的位置，设置有固定所述信号采集传感器的固定口袋。
本申请采用上述技术方案，其有益效果如下：
本申请提供的动物生命体征实时监测系统，包括：信号采集传感器、可穿戴织物及信号分析平台，所述信号采集传感器用来检测生理信息参数，所述信号采集传感器固定于所述可穿戴织物上，所述信号分析平台用于获取所述生理信息参数，并对所述生理信息参数进行分析，所述生理信息参数包括动物心率、 呼吸频率、体温、血氧饱和度及运动步数，本申请提供的动物生命体征实时监测系统，克服现有的动物生理信息监测装置的系统复杂、无法穿戴、测量参数单一、需要体内植入等缺陷，实现了在对小动物正常生命活动无干扰的情况下，实时监测小动物在运动过程中心率、呼吸频率、体温、血氧等生理信息。能够实时监测并远程记录小鼠生命体征数据变化，得到较好的数据结果。
附图说明
为了更清楚地说明本申请实施例的技术方案，下面将对本申请实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面所描述的附图仅仅是本申请的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。
图1为本申请实施例提供的动物生命体征实时监测系统的结构示意图。
图2为本申请实施例提供的可穿戴织物的结构示意图。
图3为本申请实施例1提供的信息分析平台的配置页面示意图。
图4为本申请实施例1提供的信息分析平台的系统总览页面示意图。
图5为本申请实施例1提供的实验后的效果图。
具体实施方式
下面详细描述本申请的实施例，所述实施例的示例在附图中示出，其中自始至终相同或类似的标号表示相同或类似的元件或具有相同或类似功能的元 件。下面通过参考附图描述的实施例是示例性的，旨在用于解释本申请，而不能理解为对本申请的限制。
在本申请的描述中，需要理解的是，术语“上”、“下”、“水平”、“内”、“外”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本申请和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本申请的限制。
此外，术语“第一”、“第二”仅用于描述目的，而不能理解为指示或暗示相对重要性或者隐含指明所指示的技术特征的数量。由此，限定有“第一”、“第二”的特征可以明示或者隐含地包括一个或者更多个该特征。在本申请的描述中，“多个”的含义是两个或两个以上，除非另有明确具体的限定。
为了使本申请的目的、技术方案及优点更加清楚明白，以下结合附图及实施例，对本申请进行进一步详细说明。
请参阅图1，本申请一实施例提供的一种动物生命体征实时监测系统的结构示意图，包括：信号采集传感器110、可穿戴织物120及信号分析平台130。以下详细说明各个部件之间的连接关系及其实现方式。
所述信号采集传感器110用来检测生理信息参数。所述生理信息参数包括动物心率、呼吸频率、体温、血氧饱和度及运动步数。
在本实施例中，所述信息采集传感器110连接嵌入式主控STM32F103C8T6，并通过广播协议使用蓝牙网关接收所述生理信息参数，并将所述生理信息参数传输至所述信号分析平台，所述信号分析平台根据所述生 理信息参数获取动物的心率、呼吸频率、体温、血氧饱和度及运动步数。
请参阅图2，所述可穿戴织物120采用有弹性的织布，在所述可穿戴织物120靠近动物心脏的位置，设置有固定所述信号采集传感器110的固定口袋。
在其中一些实施例中，所述信号采集传感器110包括PPG绿光模组，所述PPG绿光模组根据光电容积脉搏波描记法获取动态心率参数，所述信号分析平台对所述动态心率参数进行时域分析，计算出心率值。
在其中一些实施例中，所述信号采集传感器110包括PPG红光和红外光模组。所述PPG红光和红外光模组根据血液中含有的氧合血红蛋白HbO2和血红蛋白Hb对不同波长的光有不同的吸收特性，获取所述血氧饱和度参数，所述信号分析平台根据血氧饱和度参数计算出相应的比值，得到血氧值。
在其中一些实施例中，所述信号采集传感器110包括高导热温度传感器，所述高导热温度传感器可连续测量动物体表温度，所述信号分析平台根据所述体表温度通过内置算法计算出体温。
在其中一些实施例中，所述信号采集传感器110包括加速度计及陀螺仪，采用加速度计的a x，a y，a z和陀螺仪的m x，m y，m z，所述信号分析平台130利用中值滤波及波峰检测获取运动步数。
在其中一些实施例中，所述信号分析平台130根据所述心率值，得到呼吸率。
本申请上述实施例提供的动物生命体征实时监测系统，所述信号采集传感 器110用来检测生理信息参数，所述信号采集传感器110固定于所述可穿戴织物120上，所述信号分析平台130用于获取所述生理信息参数，并对所述生理信息参数进行分析，所述生理信息参数包括动物心率、呼吸频率、体温、血氧饱和度及运动步数。本申请提供的动物生命体征实时监测系统，克服现有的动物生理信息监测装置的系统复杂、无法穿戴、测量参数单一、需要体内植入等缺陷，实现了在对小动物正常生命活动无干扰的情况下，实时监测小动物在运动过程中心率、呼吸频率、体温、血氧等生理信息。能够实时监测并远程记录小鼠生命体征数据变化，得到较好的数据结果。
以下结合具体实施例1对本申请上述实施例提供的技术方案进行详细说明。
本实施例以小鼠为例。6-8周健康的白色小鼠；用尾吊法将小鼠以5°进行悬吊(后肢去负荷)；小鼠可以进行正常生长和活动。
本实施例中，该装置由可穿戴织物、信号采集传感器(主要是光学传感器)和生理信息采集分析系统三部分组成。(可参见图1及图2)
穿戴衣目的是用来固定信号采集传感器，读取动态心率、呼吸频率、体温、血氧饱和度SPO2等数据；并且同时使小鼠可以自由活动。因此该穿戴衣采用有弹性的织布，尺寸根据实验小鼠体型制成。为小鼠前肢留出空穴，使小鼠可以自由活动。在穿戴衣靠近小鼠心脏的位置，留出传感器的固定口袋及探测信号的空穴，使信号可以正常采集。信息采集传感器连接嵌入式主控。STM32F103C8T6，并通过广播协议使用蓝牙网关接收数据。将数据开发到我们的生理信息采集系统平台，并通过相关算法计算出小鼠的心率、呼吸频率、 体温、血氧饱和度SPO2等。
具体实现方法为：动态心率由PPG绿光模组测量，精度为5bpm、10bpm和15bpm，连续测量250ms数据广播一次。功耗超低且精确，支持广播协议读取，支持SDK/API APP读取。根据光电容积脉搏波描记法，由于动脉里有血液流动，对光的吸收有变化，得到的信号分为直流DC信号和交流DC信号。通过时域分析，计算出心率值。根据小鼠心腹面的左冠状动脉分布，设计柔性信号采集装置大小为长24mm，宽10mm。
血氧SPO2由PPG红光和红外光模组测量，功耗较高，约800uA。由于血液中含有的氧合血红蛋白HbO2和血红蛋白Hb对不同波长的光有不同的吸收特性，信号分析平台通过相关算法计算出相应的比值，得到血氧值。
体表温度由高导热温度传感器测量，连续测量小鼠体表温度，并且连续广播。精确度为±0.1摄氏度。信号分析平台通过内置算法，结合体表温度，计算出体温。信号分析平台结合测量的心率，计算出呼吸率。
运动步数主要采用加速度计的a x，a y，a z和陀螺仪的m x，m y，m z，利用中值滤波及波峰检测，解析出运动步数。采样率为25Hz。
测量得到的数据通过蓝牙连接协议上传到生理信息监测系统，使用该系统时，第一步先对用户(即小鼠)的年龄、体重进行配置，并连接传感器设备，如图3所示，为本实施例提供的信息分析平台的配置页面示意图。
第二步进入该系统总览页面，开始采集小鼠生理信息，如图4所示，为本实施例提供的系统总览页面示意图。
第三步进入详细参数页面，观察实时数据。心率、呼吸频率、体表温度每间隔30秒输出一次结果，形成折线图；血氧每2分钟输出一次测量结果，再画出柱状图。
具体实施方式：实验小鼠体征监测，由无束缚穿戴衣、传感器、受试实验小鼠、体征观察舱、电子计算机组成，受试实验小鼠悬吊。
请参阅图5，是本申请实施例实验后的效果图，可以准确测量并记录实验小鼠的心率，可知结果满足预期及要求的。
结果显示本发明设计了一个动物生命体征实时监测系统，可以实现小动物无束缚运动过程中心率、呼吸频率、体温、血氧饱和度SPO2等参数的记录，从而方便探究在正常生命活动过程中小动物相关生理信息的变化。
可以理解，以上所述实施例的各技术特征可以进行任意的组合，为使描述简洁，未对上述实施例中的各个技术特征所有可能的组合都进行描述，然而，只要这些技术特征的组合不存在矛盾，都应当认为是本说明书记载的范围。
以上仅为本申请的较佳实施例而已，仅具体描述了本申请的技术原理，这些描述只是为了解释本申请的原理，不能以任何方式解释为对本申请保护范围的限制。基于此处解释，凡在本申请的精神和原则之内所作的任何修改、等同替换和改进，及本领域的技术人员不需要付出创造性的劳动即可联想到本申请的其他具体实施方式，均应包含在本申请的保护范围之内。

Claims (8)

  1. 一种动物生命体征实时监测系统，其特征在于，包括：信号采集传感器、可穿戴织物及信号分析平台，所述信号采集传感器用来检测生理信息参数，所述信号采集传感器固定于所述可穿戴织物上，所述信号分析平台用于获取所述生理信息参数，并对所述生理信息参数进行分析，所述生理信息参数包括动物心率、呼吸频率、体温、血氧饱和度及运动步数。
  2. 如权利要求1所述的动物生命体征实时监测系统，其特征在于，所述信息采集传感器连接嵌入式主控STM32F103C8T6，并通过广播协议使用蓝牙网关接收所述生理信息参数，并将所述生理信息参数传输至所述信号分析平台，所述信号分析平台根据所述生理信息参数获取动物的心率、呼吸频率、体温、血氧饱和度及运动步数。
  3. 如权利要求1或2所述的动物生命体征实时监测系统，其特征在于，所述信号采集传感器包括PPG绿光模组，所述PPG绿光模组根据光电容积脉搏波描记法获取动态心率参数，所述信号分析平台对所述动态心率参数进行时域分析，计算出心率值。
  4. 如权利要求1或2所述的动物生命体征实时监测系统，其特征在于，所述信号采集传感器包括PPG红光和红外光模组。所述PPG红光和红外光模组根据血液中含有的氧合血红蛋白HbO2和血红蛋白Hb对不同波长的光有不同的吸收特性，获取所述血氧饱和度参数，所述信号分析平台根据血氧饱和度参数计算出相应的比值，得到血氧值。
  5. 如权利要求1或2所述的动物生命体征实时监测系统，其特征在于，所述信号采集传感器包括高导热温度传感器，所述高导热温度传感器可连续测量动物体表温度，所述信号分析平台根据所述体表温度通过内置算法计算出体温。
  6. 如权利要求1或2所述的动物生命体征实时监测系统，其特征在于，所述信号采集传感器包括加速度计及陀螺仪，采用加速度计的a x，a y，a z和陀螺仪的m x，m y，m z，所述信号分析平台利用中值滤波及波峰检测获取运动步数。
  7. 如权利要求3所述的动物生命体征实时监测系统，其特征在于，所述信号分析平台根据所述心率值，得到呼吸率。
  8. 如权利要求1所述的动物生命体征实时监测系统，其特征在于，所述可穿戴织物采用有弹性的织布，在所述可穿戴织物靠近动物心脏的位置，设置有固定所述信号采集传感器的固定口袋。
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