WO2024103299A1 - 一种简易可伸缩小鼠吸入麻醉装置 - Google Patents

一种简易可伸缩小鼠吸入麻醉装置 Download PDF

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Publication number
WO2024103299A1
WO2024103299A1 PCT/CN2022/132319 CN2022132319W WO2024103299A1 WO 2024103299 A1 WO2024103299 A1 WO 2024103299A1 CN 2022132319 W CN2022132319 W CN 2022132319W WO 2024103299 A1 WO2024103299 A1 WO 2024103299A1
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anesthesia
cylinder
hollow cylinder
cabin
hollow
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French (fr)
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王立娟
王志杰
王立平
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Shenzhen Institute of Advanced Technology of CAS
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Shenzhen Institute of Advanced Technology of CAS
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Priority to PCT/CN2022/132319 priority Critical patent/WO2024103299A1/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D3/00—Arrangements for supporting or fettering animals for veterinary purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices

Definitions

  • the invention relates to a simple and retractable mouse inhalation anesthesia device.
  • mice are commonly used experimental animals in the field of scientific research. Due to animal ethics requirements and considering the biological characteristics of mice with agile movements, mice often need to be anesthetized when conducting some experiments. Compared with intraperitoneal injection anesthesia, isoflurane gas inhalation anesthesia has faster anesthesia induction and awakening, and a lower mortality rate. It is a safer and more efficient anesthesia method. However, isoflurane inhalation anesthesia often requires a gas anesthesia machine to anesthetize mice through an air pump. Existing anesthesia machines are expensive and not easy to carry. In the absence of anesthesia machines or when anesthesia machines are not easy to carry, experimenters cannot use isoflurane gas to anesthetize experimental animals quickly and safely. Therefore, it is very necessary to find a simple and portable anesthesia device.
  • the Chinese utility model patent with application number 202123386439.7 discloses a simple anesthesia device for mice. When it is used, the awake mouse needs to be fixed on the mouse trap before inducing anesthesia. The process of fixing the mouse awake is a great stress to the mouse, which in turn affects the experimental indicators and greatly increases the risk of experimenters being bitten by mice. Therefore, this solution is not actually feasible. At the same time, the position of the strap affects operations such as surgery, and the tightness of the fixing strap varies from person to person, causing suffocation of the mouse and the risk of compression of internal organs.
  • the present invention provides a simple and retractable mouse inhalation anesthesia device. During use, the mouse does not need to be fixed or strapped in a conscious state, and the mouse can be directly placed inside the device for induced anesthesia.
  • It includes an anesthetic placement unit, a surgical fixation board and an anesthesia cabin;
  • the front end interface is connected to the front end of the telescopic bellows through a conical cover, and the rear end of the telescopic bellows is provided with a cylinder;
  • the tail base is a hollow cylinder, one end of which is nested and connected with the cylinder, and the other end is provided with a curling edge, and a double-valve silicone sleeve is sleeved on the curling edge, and the double-valve silicone sleeve is used to seal the anesthesia cabin;
  • the inner wall of the cylinder is provided with two slide grooves;
  • the two sides of the surgical fixation plate are respectively matched with the slide grooves so that the surgical fixation plate can be translated in the anesthesia cabin, and the double-valve silicone sleeve is provided with a linear opening corresponding to the surgical fixation plate, and the surgical fixation plate can extend out of the anesthesia cabin from the linear opening;
  • the anesthetic placement part includes a hollow cylinder and an end cover; one end of the hollow cylinder is closed, and a hollow hole is provided on the closed end, and the end cover is arranged at the other end of the hollow cylinder for sealing the hollow cylinder; the end of the hollow cylinder with the hollow hole is connected to the front end interface of the anesthesia cabin.
  • the above-mentioned front-end interface is a cylindrical structure with one end closed, and a hollow hole is provided on the closed end.
  • the hollow cylinder is rotatably connected to the front-end interface of the anesthesia cabin, and the closed ends of the two are in contact. By rotating the cylindrical structure, the overlapping area of the hollow cylinder and the hollow hole in the front-end interface can be adjusted.
  • a buckle is provided at the end of the hollow cylinder of the anesthetic placement part, and a buckle groove is provided on the side wall of the front end interface for buckling with the end of the hollow cylinder.
  • the buckle and the buckle groove cooperate to realize the rotational connection between the hollow cylinder and the front end interface of the anesthesia cabin.
  • the surgical fixation plate is provided with a platform on one side close to the front end interface, and a tooth socket is provided in the platform to fix the mouse incisors.
  • the above-mentioned surgical fixation plate is provided with a fixing frame on one side close to the front end interface, and the fixing frame includes two columns, the tops of the two columns are respectively connected to a horizontal cross bar, and the ends of the two horizontal cross bars are connected to a U-shaped structure.
  • the fixing frame can fix the mouse incisors, and the fixing frame is suitable for fixing the mouse when it is in a supine position.
  • two supporting legs are respectively arranged below the conical cover and the cylinder.
  • the end cover is provided with a gas circuit interface, which allows air to flow into the anesthesia cabin body, and can also be connected to compressed air or oxygen, or can be connected to a gas anesthesia machine.
  • cone cover, cylinder, telescopic bellows and tail base are all made of transparent materials.
  • cone cover, cylinder and tail base are all made of transparent hard plastic.
  • the hollow holes in the hollow cylinder and the front end interface are six fan-shaped hollow holes.
  • the present invention provides a simple and retractable mouse inhalation anesthesia device, which can reduce the anesthesia-induced stress response and enhance the continuity between anesthesia induction and anesthesia maintenance.
  • the present invention can complete anesthesia induction and anesthesia maintenance in short surgical experimental operations in the same device, meeting the needs of anesthesia induction and maintenance of anesthesia continuity in mice during short surgical operations, and thus can solve the problem of not being able to obtain anesthesia machines in time during short surgical anesthesia (anesthesia machines and other devices are expensive and bulky and often cannot be obtained in time). It has the advantages of simple operation, small space occupation, low cost, and high work efficiency.
  • FIG1 is an overall structural diagram of a simple and retractable mouse inhalation anesthesia device according to an embodiment of the present invention
  • FIG2 is a perspective view of FIG1;
  • FIG3 is an exploded view of the anesthetic placement unit in FIG1 ;
  • FIG4 is a structural diagram of the anesthesia cabin in FIG1 ;
  • FIG5 is a perspective view of FIG4
  • FIG6 is a structural diagram of the tail base in FIG1 ;
  • FIG7 is a structural diagram of the surgical fixation plate in FIG1 ;
  • FIG8 is a structural diagram of another embodiment of a surgical fixation plate
  • FIG. 9 is a structural diagram of another embodiment of an anesthetic placement unit.
  • a simple retractable mouse inhalation anesthesia device includes an anesthetic placement part, a surgical fixation plate 12 and an anesthesia cabin.
  • the anesthesia cabin includes a front interface 1, a retractable bellows 2 and a tail base 3; the front interface 1 is connected to the front end of the retractable bellows 2 through a conical cover 4, and the rear end of the retractable bellows 2 is provided with a cylinder 5; the tail base 3 is a hollow cylinder, one end of which is nested and connected with the cylinder 5, and the other end is provided with a curling edge, and a double-valve silicone sleeve 6 is sleeved on the curling edge, and the double-valve silicone sleeve 6 is used to seal the anesthesia cabin; the inner wall of the cylinder 5 is provided with two slide grooves 7; the two sides of the surgical fixation plate 12 are respectively matched with the slide grooves 7 so that the surgical fixation plate 12 can be translated in the
  • the anesthetic placement part includes a hollow cylinder 8 and an end cover 9; one end of the hollow cylinder 8 is closed, and a hollow hole is provided on the closed end.
  • the anesthetic cotton ball is placed in the hollow cylinder 8, and the end cover 9 is arranged at the other end of the hollow cylinder 8 to seal the hollow cylinder 8; the end of the hollow cylinder 8 with the hollow hole is connected to the front end interface 1 of the anesthesia cabin.
  • the edges of the surgical fixing plate 12 on both sides can be matched with the slide groove 7 on the inner wall of the rear part of the anesthesia chamber.
  • the surgical fixing plate 12 can move axially along the slide groove 7, and can pull out and fix the anesthetized mouse through the linear opening of the double-valve silicone sleeve 6. While fixing the mouse, the head or mouth and nose of the mouse needs to be kept in the main body of the anesthesia chamber, and the anesthesia depth can be adjusted by retracting the retractable bellows 2.
  • the front end interface 1 is a cylindrical structure with one end closed, and a hollow hole is provided on the closed end.
  • the hollow cylinder 8 is rotatably connected to the front end interface 1 of the anesthesia cabin, and the closed ends of the two are in contact.
  • the size of the overlapping area of the hollow cylinder 8 and the hollow hole in the front end interface 1 can be adjusted by rotating the cylindrical structure.
  • the hollow holes of the two overlap to allow air to flow between the anesthetic placement portion and the anesthesia cabin.
  • the cylinder 5 is rotated to adjust the depth of anesthesia or close it.
  • the end of the hollow cylinder 8 of the anesthetic placement part is provided with a buckle 10, and the side wall of the front interface 1 is provided with an "L-shaped" buckle groove 11 that cooperates with the buckle 10 at the end of the hollow cylinder 8.
  • the buckle 10 and the buckle groove 11 Through the cooperation between the buckle 10 and the buckle groove 11, the hollow cylinder 8 and the front interface 1 of the anesthesia cabin are rotatably connected.
  • the anesthetic cotton ball placement part rotates counterclockwise in the "L-shaped" buckle groove 11 through the buckle 10 to seal the air connection between the anesthetic cotton ball placement part and the anesthesia cabin, and rotates closed when the anesthetic is not needed or the anesthesia needs to be reduced, which plays a role in adjusting the depth of anesthesia.
  • the surgical fixation plate 12 is provided with a 10 mm high platform 13 near the front end interface 1, and a tooth socket is provided in the platform 13 to fix the mouse incisors.
  • the purpose of this design is to fix the mouse in a prone position.
  • the surgical fixing plate 12 is provided with a fixing frame 14 near the front end interface 1, and the fixing frame 14 includes two columns, the tops of the two columns are respectively connected to a horizontal cross bar, and the ends of the two horizontal cross bars are connected to a U-shaped structure, and the fixing frame 14 can fix the mouse incisors.
  • This design is suitable for fixing the mouse in a supine position, and the suspended metal rod can hook the mouse teeth from above.
  • two legs 15 are respectively provided under the cone cover 4 and the cylinder 5 to support the simple and retractable mouse inhalation anesthesia device to keep it stable.
  • the present invention is composed of an anesthetic placement part, an anesthesia cabin, a tail base and a double-valve silicone sleeve.
  • the main purpose of the present invention is to provide anesthesia for short and minor surgeries (such as perfusion, orbital blood sampling, etc.).
  • the device is not limited to anesthesia for short and minor surgeries.
  • an air circuit interface 16 is provided on the end cover 9.
  • the air circuit interface 16 allows air to flow into the anesthesia cabin body to increase the anesthesia time; compressed air or oxygen can also be introduced into the anesthesia cabin body through the air circuit interface, thereby further increasing the anesthesia time; a gas anesthesia machine, such as an isoflurane gas anesthesia machine, can also be connected to the air circuit of the gas anesthesia machine, thereby realizing the combination of the present invention and the gas anesthesia machine, that is, anesthesia can be induced, and long-term stable anesthesia can also be achieved.
  • a gas anesthesia machine such as an isoflurane gas anesthesia machine
  • the cone cover 4, cylinder 5, retractable bellows 2, and tail base 3 are all made of transparent materials, so that the operator can see the state of the mouse during the entire operation.
  • the cone cover 4, cylinder 5, and tail base 3 are all made of transparent hard plastic.
  • the hollow cylinder 8 and the hollow holes in the front end interface 1 are six fan-shaped hollow holes of the same size, and the six fan-shaped hollow holes are arranged in a circumferentially uniform manner, so that the overlapping area of the hollow cylinder 8 and the hollow holes in the front end interface 1 can be adjusted by rotating the cylindrical structure.
  • an appropriate amount of isoflurane or other inhalation anesthetics are injected into the center of the cotton ball in the anesthetic cotton ball placement part.
  • the anesthetic cotton ball placement part is connected to the anesthesia cabin along the L-shaped buckle groove 11, and the anesthetic gas will volatilize into the anesthesia cabin.
  • the air diffusion with the anesthesia cabin body can be reduced or closed by rotating the anesthetic cotton ball placement part buckle 10 to the outer end of the L-shaped buckle groove 11 counterclockwise, which is used to adjust the anesthetic dosage.
  • the mouse incisors are inserted into the linear opening of the double-valve silicone sleeve 6 to fix the mouse incisors on the alveolar socket, and then the mouse body is further fixed according to the experimental requirements.
  • the mouse head or mouth and nose are kept inside the main body of the anesthesia chamber (inside the double-valve silicone), and the depth of anesthesia is adjusted by rotating the anesthetic placement buckle 10 and the telescopic bellows 2, and the depth of anesthesia is judged by observing breathing, heartbeat, and stimulation.
  • the description of the present invention is all for mice. If the experimental animals are replaced with rats, the present invention is also applicable, and it is only necessary to adjust the size of the entire design.

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
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Abstract

一种简易可伸缩小鼠吸入麻醉装置，包括麻醉剂放置部、手术固定板（12）和麻醉舱；麻醉舱包括前端接口（1）、可伸缩波纹管（2）、圆筒（5）和尾部底座（3）；可伸缩波纹管（2）与圆筒（5）、尾部底座（3）顺序连接，尾部底座（3）上套设双瓣膜硅胶套（6），双瓣膜硅胶套（6）用于对麻醉舱进行密封；圆筒（5）内壁设有两道滑槽（7）；手术固定板（12）的两侧与滑槽（7）配合，双瓣膜硅胶套（6）上设有与手术固定板（12）对应的线性开口；麻醉剂放置部包括中空圆柱体（8）和端盖（9）；中空圆柱体（8）一端封闭，封闭端上设有镂空孔，端盖（9）用于对中空圆柱体（8）进行密封；中空圆柱体（8）设有镂空孔的一端与麻醉舱的前端接口（1）连接。使用过程中，无需在清醒状态下固定小鼠、拉紧绑带等操作，可直接将小鼠放置于装置内部进行麻醉诱导。

Description

一种简易可伸缩小鼠吸入麻醉装置 技术领域
本发明涉及一种简易可伸缩小鼠吸入麻醉装置。
背景技术
小鼠作为科研领域常用的实验动物。出于动物伦理需求，同时考虑到小鼠动作敏捷的生物特点，在进行一些实验时常需要对小鼠进行麻醉。异氟烷气体吸入麻醉相较于腹腔注射麻醉，麻醉诱导以及苏醒较快，且死亡率更低，是一种更安全高效的麻醉方式。然而异氟烷吸入麻醉常常需要气体麻醉机通过气泵进行小鼠麻醉。现有麻醉机贵重且不易携带，在无麻醉机或不易携带麻醉机的情况下，实验人员不能够使用异氟烷气体快速、安全的将实验动物麻醉。因此，寻求一种简易、可携带的麻醉装置是十分必要的。
申请号为202123386439.7的中国实用新型专利公开了一种小鼠简易麻醉装置，其在具体使用时，需要先把清醒小鼠固定在夹鼠装置上，再开始诱导麻醉。清醒固定小鼠的过程是对小鼠的极大应激，进而影响实验指标，也会大大增加实验人员被小鼠咬伤的风险。因此，其实该方案不具备实际可操作性。同时，绑带位置影响手术等操作，且固定绑带的松紧因人而异，造成小鼠窒息，内脏受压风险等问题。
发明内容
本发明提出一种简易可伸缩小鼠吸入麻醉装置，在使用过程中，无需在清醒状态下固定、拉紧绑带等操作，可直接将小鼠放置于装置内部进行诱导麻醉。
本发明解决上述问题的技术方案是：一种简易可伸缩小鼠吸入麻醉装置，其特殊之处在于：
包括麻醉剂放置部、手术固定板和麻醉舱；
所述麻醉舱包括前端接口、可伸缩波纹管和尾部底座；
所述前端接口与可伸缩波纹管的前端通过圆锥罩连接，可伸缩波纹管的后端设有圆筒；尾部底座为一空心柱体，其一端与圆筒嵌套连接，另一端设有卷边，卷边上套设双瓣膜硅胶套，双瓣膜硅胶套用于对麻醉舱进行密封；所述圆筒内壁设有两道滑槽；
所述手术固定板的两侧分别与滑槽配合使手术固定板可在麻醉舱内进行平移，所述双瓣膜硅胶套上设有与手术固定板对应的线性开口，手术固定板可从线性开口伸出麻醉舱；
所述麻醉剂放置部包括中空圆柱体和端盖；中空圆柱体一端封闭，封闭端上设有镂空孔，端盖设置在中空圆柱体的另一端用于对中空圆柱体进行密封；中空圆柱体设有镂空孔的一端与麻醉舱的前端接口连接。
进一步地，上述前端接口为一端封闭的圆筒结构，其封闭端上设有镂空孔，中空圆柱体与麻醉舱的前端接口旋转连接，二者的封闭端相接触，通过旋转圆筒结构可以实现调整中空圆柱体和前端接口内的镂空孔重合的面积大小。
进一步地，上述麻醉剂放置部的中空圆柱体端部设有卡扣，前端接口侧壁设有与中空圆柱体端部卡扣配合的卡扣槽，通过卡扣与卡扣槽的配合，实现中空圆柱体与麻醉舱的前端接口旋转连接。
进一步地，上述手术固定板靠近前端接口一侧设有平台，所述平台内设有牙槽，可固定小鼠门齿。
进一步地，上述手术固定板靠近前端接口一侧设有固定架，所述固定架包括两个立柱，两个立柱顶部分别连接一个水平横杆，两个水平横杆的端部连接一个U型结构，所述固定架可固定小鼠门齿，固定架适用于小鼠为仰卧姿势时的固定。
进一步地，上述圆锥罩和圆筒下方分别设置有两个支腿。
进一步地，上述端盖上设有气路接口，该气路接口可以让空气流入麻醉舱主体，也可以接压缩空气或氧气，也可以与气体麻醉机相连。
进一步地，上述圆锥罩、圆筒、可伸缩波纹管、尾部底座均为透明材料制成。
进一步地，上述圆锥罩、圆筒、尾部底座均为透明的硬质塑料制成。
进一步地，上述中空圆柱体和前端接口内的镂空孔均为六个扇形镂空孔。
本发明的优点：
1、本发明提出一种简易可伸缩小鼠吸入麻醉装置，可以减轻麻醉诱导应激反应，加强麻醉诱导和麻醉维持之间的连续性。
2、本发明在使用过程中，不存在清醒状态下固定、拉紧绑带等操作，直接将小鼠放置于装置内部进行诱导麻醉。
3、本发明在使用过程中，可在同一装置中完成麻醉诱导以及短小手术实验操作中的麻醉维持，满足小鼠短小手术麻醉诱导与维持麻醉连续性的需求，进而可以解决短小手术麻醉时无法及时获取麻醉机(麻醉机等装置昂贵且笨重，常无法及时获取)的问题，具有操作简单，占据空间小，成本低，工作效率高等优点。
附图说明
图1是本发明实施例中简易可伸缩小鼠吸入麻醉装置的整体结构图；
图2是图1的透视图；
图3是图1中的麻醉剂放置部的分解图；
图4是图1中的麻醉舱结构图；
图5是图4的透视图；
图6是图1中的尾部底座结构图；
图7是图1中的手术固定板结构图；
图8是手术固定板的另一种实施例结构图；
图9是麻醉剂放置部的另一种实施例结构图。
图中所示：
1-前端接口；2-可伸缩波纹管；3-尾部底座；4-圆锥罩；5-圆筒；6-双瓣膜硅胶套；7-滑槽；8-中空圆柱体；9-端盖；10-卡扣；11-卡扣槽；12-手术固定板；13-平台；14-固定架；15-支腿；16-气路接口。
具体实施方式
为使本发明实施方式的目的、技术方案和优点更加清楚，下面将结合本发明实施方式中的附图，对本发明实施方式中的技术方案进行清楚、完整地描述，显然，所描述的实施方式是本发明一部分实施方式，而不是全部的实施方式。基于本发明中的实施方式，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施方式，都属于本发明保护的范围。因此，以下对在附图中提供的本发明的实施方式的详细描述并非旨在限制要求保护的本发明的范围，而是仅仅表示本发明的选定实施方式。
参见图1和图2，一种简易可伸缩小鼠吸入麻醉装置，包括麻醉剂放置部、手术固定板12和麻醉舱。所述麻醉舱包括前端接口1、可伸缩波纹管2和尾部底座3；所述前端接口1与可伸缩波纹管2的前端通过圆锥罩4连接，可伸缩波纹管2的后端设有圆筒5；尾部底座3为一空心柱体，其一端与圆筒5嵌套连接，另一端设有卷边，卷边上套设双瓣膜硅胶套6，双瓣膜硅胶套6用于对麻醉舱进行密封；所述圆筒5内壁设有两道滑槽7；所述手术固定板12的两侧分别与滑槽7配合使手术固定板12可在麻醉舱内进行平移，所述双瓣膜硅胶套6上设有与手术固定板12对应的线性开口，手术固定板12可从线性开口伸出麻醉舱。所述麻醉剂放置部包括中空圆柱体8和端盖9；中空圆柱体8一端封闭，封闭端上设有镂空孔，麻醉剂棉球放置在中空圆柱体8内，端盖9设置在中空圆柱体8的另一端用于对中空圆柱体8进行密封；中空圆柱体8设有镂空孔的一端与麻醉舱的前端接口1连接。
手术固定板12两侧边缘部位可与麻醉舱后部内壁上的滑槽7相配合。手术固定板12可延滑槽7轴向运动，可通过双瓣膜硅胶套6线性开口，将麻醉后的小鼠拉出并固定。固定小鼠的同时，需保持小鼠头部或口鼻在麻醉舱主体内，并通过伸缩可伸缩波纹管2来实现对麻醉深度的调整。
参见图4和图5，作为本发明的一个优选实施例，所述前端接口1为一端封闭的圆筒结构，其封闭端上设有镂空孔，中空圆柱体8与麻醉舱的前端接口1旋转连接，二者的封闭端相接触，通过旋转圆筒结构可以实现调整中空圆柱体8和前端接口1内的镂空孔重合的面积大小。
二者的镂空孔重合使麻醉剂放置部与麻醉舱之间的空气连通，在不需要麻醉剂或需要减浅麻醉时旋转圆筒5，起调节麻醉深浅或关闭的作用。
参见图1、图2、图4和图5，作为本发明的一个优选实施例，所述麻醉剂放置部的中空圆柱体8端部设有卡扣10，前端接口1侧壁设有与中空圆柱体8端部卡扣10配合的“L型”卡扣槽11，通过卡扣10与卡扣槽11的配合，实现中空圆柱体8与麻醉舱的前端接口1旋转连接。麻醉剂棉球放置部通过卡扣10在“L型”卡扣槽11逆时针旋转，可密封麻醉剂棉花放置部与麻醉舱之间的空气连接，在不需要麻醉剂或需要减浅麻醉时旋转关闭，起调节麻醉深浅作用。
参见图7，作为本发明的一个优选实施例，所述手术固定板12靠近前端接口1一侧设有10mm高的平台13，所述平台13内设有牙槽，可固定小鼠门齿。这一设计的目的是在小鼠俯卧姿势下固定小鼠。
参见图8，作为本发明的一个优选实施例，所述手术固定板12靠近前端接口1一侧设有固定架14，所述固定架14包括两个立柱，两个立柱顶部分别连接一个水平横杆，两个水平横杆的端部连接一个U型结构，所述固定架14可固定小鼠门齿。这一设计适用于在小鼠仰卧姿势下固定小鼠，悬空的金属杆可以从上方勾住小鼠牙齿。
参见图1和图2，作为本发明的一个优选实施例，所述圆锥罩4和圆筒5下方分别设置有两个支腿15，支撑简易可伸缩小鼠吸入麻醉装置，使其保持稳定。
本发明由麻醉剂放置部、麻醉舱、尾部底座及双瓣膜硅胶套组成。本发明的主要目的是针对短小手术麻醉(如灌流，眼眶取血等)。然而，在实际使用过程中，该装置并不限于短小手术麻醉。为实现这一目的，参见图9，在所述端盖9上设有气路接口16。该气路接口16可以让空气流入麻醉舱主体，增加麻醉时 间；也可以把压缩空气或氧气通过该气路接口引入麻醉舱主体，从而进一步增加麻醉时间；还可以把气体麻醉机比如，异氟烷气体麻醉机气路接到该气路接口，从而实现本发明和气体麻醉机的联用，即可以诱导麻醉，也可以实现长时间稳定麻醉。
所述圆锥罩4、圆筒5、可伸缩波纹管2、尾部底座3均为透明材料制成，这样可使操作人员在整个手术过程中看到小鼠的状态。优选地，所述圆锥罩4、圆筒5、尾部底座3均为透明的硬质塑料制成。
参见图2、图3和图9，作为本发明的一个优选实施例，所述中空圆柱体8和前端接口1内的镂空孔均为六个尺寸相同的扇形镂空孔，六个扇形镂空孔以圆周均布的方式设置，使得通过旋转圆筒结构可以实现调整中空圆柱体8和前端接口1内的镂空孔重合的面积大小。
本发明提出的简易可伸缩小鼠吸入麻醉装置在使用时，首先向麻醉剂棉球放置部内的棉球中心注入适量异氟烷等吸入麻醉药，注药后，沿L型卡扣槽11连接麻醉剂棉球放置部与麻醉舱，麻醉气体会挥发进入麻醉舱。逆时针旋转麻醉剂棉球放置部卡扣10至L型卡扣槽11外端可减小或关闭与麻醉舱主体的空气弥散，用于调节麻醉剂药量。然后取下尾部底座，直接将实验小鼠整体放入麻醉舱主体中，并盖上尾部底座以密闭麻醉舱主体，进行诱导麻醉。这样就不需要在小鼠清醒时对其进行固定，不会造成麻醉时应激反应剧烈的情况。因整体装置均为透明，可实时观察小鼠呼吸、麻醉深度等。小鼠诱导麻醉完成后，拉动手术固定板，通过双瓣膜硅胶套线性开口，将麻醉后的小鼠身体拉出(保持小鼠头部或口鼻在麻醉舱主体内)。辅以镊子伸入双瓣膜硅胶套6线性开口内，把小鼠门齿固定在牙槽上，再依实验需求对小鼠身体做进一步固定。根据实验要求，对小鼠进行手术实验期间，保持小鼠头部或口鼻在麻醉舱主体内部(双瓣膜硅胶内部)，通过旋转麻醉剂放置部卡扣10以及伸缩可伸缩波纹管2调节麻醉深浅，并通过观察呼吸、心跳、刺激判断麻醉深浅。
另外，本发明的描述都是针对小鼠，如果把实验动物换成大鼠，同样适用 本发明，只需要调整整个设计的大小尺寸就可以。
以上所述仅为本发明的实施例，并非以此限制本发明的保护范围，凡是利用本发明说明书及附图内容所作的等效结构或等效流程变换，或直接或间接运用在其他相关的系统领域，均同理包括在本发明的保护范围内。

Claims (10)

  1. 一种简易可伸缩小鼠吸入麻醉装置，其特征在于：
    包括麻醉剂放置部、手术固定板(12)和麻醉舱；
    所述麻醉舱包括前端接口(1)、可伸缩波纹管(2)和尾部底座(3)；
    所述前端接口(1)与可伸缩波纹管(2)的前端通过圆锥罩(4)连接，可伸缩波纹管(2)的后端设有圆筒(5)；尾部底座(3)为一空心柱体，其一端与圆筒(5)嵌套连接，另一端设有卷边，卷边上套设双瓣膜硅胶套(6)，双瓣膜硅胶套(6)用于对麻醉舱进行密封；所述圆筒(5)内壁设有两道滑槽(7)；
    所述手术固定板(12)的两侧分别与滑槽(7)配合使手术固定板(12)可在麻醉舱内进行平移，所述双瓣膜硅胶套(6)上设有与手术固定板(12)对应的线性开口，手术固定板(12)可从线性开口伸出麻醉舱；
    所述麻醉剂放置部包括中空圆柱体(8)和端盖(9)；中空圆柱体(8)一端封闭，封闭端上设有镂空孔，端盖(9)设置在中空圆柱体(8)的另一端用于对中空圆柱体(8)进行密封；中空圆柱体(8)设有镂空孔的一端与麻醉舱的前端接口(1)连接。
  2. 根据权利要求1所述的一种简易可伸缩小鼠吸入麻醉装置，其特征在于：
    所述前端接口(1)为一端封闭的圆筒结构，其封闭端上设有镂空孔，中空圆柱体(8)与麻醉舱的前端接口(1)旋转连接，二者的 封闭端相接触，通过旋转圆筒结构可以实现中空圆柱体(8)和前端接口(1)内的镂空孔重合的面积大小。
  3. 根据权利要求2所述的一种简易可伸缩小鼠吸入麻醉装置，其特征在于：
    所述麻醉剂放置部的中空圆柱体(8)端部设有卡扣(10)，前端接口(1)侧壁设有与中空圆柱体(8)端部卡扣(10)配合的卡扣槽(11)，通过卡扣(10)与卡扣槽(11)的配合，实现中空圆柱体(8)与麻醉舱的前端接口(1)旋转连接。
  4. 根据权利要求3所述的一种简易可伸缩小鼠吸入麻醉装置，其特征在于：
    所述手术固定板(12)靠近前端接口(1)一侧设有平台(13)，所述平台(13)内设有牙槽，可固定小鼠门齿。
  5. 根据权利要求3所述的一种简易可伸缩小鼠吸入麻醉装置，其特征在于：
    所述手术固定板(12)靠近前端接口(1)一侧设有固定架(14)，所述固定架(14)包括两个立柱，两个立柱顶部分别连接一个水平横杆，两个水平横杆的端部连接一个U型结构，所述固定架(14)可固定小鼠门齿。
  6. 根据权利要求1-5任一所述的一种简易可伸缩小鼠吸入麻醉装置，其特征在于：
    所述圆锥罩(4)和圆筒(5)下方分别设置有两个支腿(15)。
  7. 根据权利要求1-5任一所述的一种简易可伸缩小鼠吸入麻醉装置，其特征在于：
    所述端盖(9)上设有气路接口(16)。
  8. 根据权利要求1-5任一所述的一种简易可伸缩小鼠吸入麻醉装置，其特征在于：
    所述圆锥罩(4)、圆筒(5)、可伸缩波纹管(2)、尾部底座(3)均为透明材料制成。
  9. 根据权利要求1-5任一所述的一种简易可伸缩小鼠吸入麻醉装置，其特征在于：
    所述圆锥罩(4)、圆筒(5)、尾部底座(3)均为透明的硬质塑料制成。
  10. 根据权利要求1-5任一所述的一种简易可伸缩小鼠吸入麻醉装置，其特征在于：
    所述中空圆柱体(8)和前端接口(1)内的镂空孔均为六个扇形镂空孔。
PCT/CN2022/132319 2022-11-16 2022-11-16 一种简易可伸缩小鼠吸入麻醉装置 Ceased WO2024103299A1 (zh)

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KR20180138392A (ko) * 2017-06-21 2018-12-31 동아대학교 산학협력단 실험용 쥐의 영상촬영용 고정장치
CN209899665U (zh) * 2019-03-06 2020-01-07 张良斌 一种简易快速麻醉小鼠的装置
CN214908622U (zh) * 2020-12-04 2021-11-30 中国农业科学院特产研究所 一种小鼠简易麻醉装置
CN215080184U (zh) * 2020-12-14 2021-12-10 华中科技大学同济医学院附属协和医院 一种大小鼠麻醉和尾静脉注射装置
CN114343915A (zh) * 2022-01-20 2022-04-15 徐州医科大学 一种小鼠吸入麻醉诱导维持装置

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6352076B1 (en) * 1999-07-01 2002-03-05 Larry G. French Anesthesia induction chamber for small animals
KR20180138392A (ko) * 2017-06-21 2018-12-31 동아대학교 산학협력단 실험용 쥐의 영상촬영용 고정장치
CN209899665U (zh) * 2019-03-06 2020-01-07 张良斌 一种简易快速麻醉小鼠的装置
CN214908622U (zh) * 2020-12-04 2021-11-30 中国农业科学院特产研究所 一种小鼠简易麻醉装置
CN215080184U (zh) * 2020-12-14 2021-12-10 华中科技大学同济医学院附属协和医院 一种大小鼠麻醉和尾静脉注射装置
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