Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
  • A61N5/00—Radiation therapy
  • A61N5/06—Radiation therapy using light

Definitions

• This disclosure relates to a skin-acting device.
• the present disclosure therefore aims to provide a skin action device that can appropriately act on human skin.
• An information acquisition unit that acquires target part information regarding a target part of a user's body; a control unit that controls an action of an action source on the target site based on target site information from the information acquisition unit, or controls a position of the action source.
• This disclosure makes it possible to provide a skin action device that can appropriately act on human skin.
• FIG. 13 is an image of how to use the app.
• FIG. 1 is a perspective view of a mask (1).
• FIG. FIG. 2 is a perspective view of the mask.
• FIG. 2 is a schematic diagram showing a state in which a light source is placed at a fixed distance from a face.
• FIG. 1 is an explanatory diagram of a mask equipped with electrodes. 4 is an explanatory diagram of characteristics of light (predetermined light) emitted from an LED.
• FIG. FIG. 1 is a diagram showing test results relating to the melanin production inhibitory effect depending on the wavelength of light irradiated to the skin.
• FIG. 2 is a diagram showing an outline of a control system for the light irradiation device.
• FIG. 1 is a perspective view of a mask (1).
• FIG. FIG. 2 is a perspective view of the mask.
• FIG. 2 is a schematic diagram showing a state in which a light
• FIG. 1 is a diagram showing test results (part 1) concerning the melanin production inhibitory effect of green LED light irradiation.
• FIG. 13 is a diagram showing test results (part 2) concerning the melanin production inhibitory effect of green LED light irradiation.
• FIG. 13 is a diagram showing test results (part 3) concerning the melanin production inhibitory effect of irradiation with green LED light.
• FIG. 13 is a diagram showing test results (part 4) concerning the melanin production inhibitory effect of irradiation with green LED light.
• FIG. 5 is a diagram showing test results (part 5) concerning the melanin production inhibitory effect of green LED light irradiation.
• FIG. 13 is a diagram showing test results (part 6) concerning the melanin production inhibitory effect of irradiation with green LED light.
• FIG. 20 is a table showing evaluation results obtained from the test results of FIGS. 16 to 19 .
• FIG. 13 is a diagram showing test results (part 7) concerning the melanin production inhibitory effect by irradiation with green LED light.
• FIG. 13 is a diagram showing test results (part 8) concerning the melanin production inhibitory effect by irradiation with green LED light.
• FIG. 13 is a diagram showing test results (part 9) concerning the melanin production inhibitory effect by irradiation with green LED light.
• FIG. 10 is a diagram showing test results (part 10) concerning the melanin production inhibitory effect of irradiation with green LED light.
• 1 is a table showing the relationship between the radiation intensity of green LED light and the effect (the effect of suppressing melanin production).
• 1 is a graph (part 1) showing the relationship between the radiation intensity of green LED light and the effect.
• 2 is a graph (part 2) showing the relationship between the radiation intensity of green LED light and the effect.
• 13 is a graph (part 3) showing the relationship between the radiation intensity of green LED light and the effect. 13 is a graph showing another test result regarding the relationship between the radiant intensity of green LED light and the effect.
• FIG. 13 is a diagram showing test results (part 1) relating to differences in melanin production inhibitory effects caused by differences in wavelength.
• FIG. 13 is a diagram showing test results (part 2) relating to differences in melanin production inhibitory effects caused by differences in wavelength.
• FIG. 13 is a diagram showing test results (part 3) relating to differences in melanin production inhibitory effects caused by differences in wavelength.
• FIG. 1 shows test results regarding the expression level of keratin 10.
• FIG. 2 is a perspective view of the front side of the mask.
• FIG. 2 is a perspective view of the rear side of the mask.
• 1A to 1C are diagrams showing the positional relationship between the face and the wires.
• FIG. 13 is a diagram showing the tensile force acting on the mask.
• 1A to 1C are diagrams showing the positional relationship between the face and the wires.
• FIG. 13 is a diagram showing the tensile force acting on the mask.
• FIG. FIG. 13 is a diagram showing the relationship between LED distance and output.
• FIG. 13 is a diagram showing the arrangement of two types of LEDs. 1A to 1C are diagrams for explaining the reason why light unevenness occurs and the reason why light unevenness is eliminated, respectively.
• FIG. 11 is a comparison diagram showing a comparison of light output, etc.
• FIG. 2 is a perspective view of a mask and a neck cover.
• 1A and 1B are diagrams illustrating a hard surface type mask.
• 1A and 1B are diagrams illustrating a soft multi-mask type.
• 13 is a diagram showing the results (test results) of evaluating the variation in output of a plurality of green LEDs in a high-density arrangement area according to the present embodiment.
• FIG. FIG. 40 is a diagram showing evaluation results (test results) similar to those in FIG.
• FIG. 40 is a diagram showing evaluation results (test results) similar to those in FIG. 39, when the predetermined distance is 10 mm.
• FIG. 13 is an explanatory diagram of test results showing the usefulness of small LEDs among the LEDs forming a plurality of green LEDs.
• FIG. 43 is a diagram illustrating the principle corresponding to the test results of FIG. 42 .
• FIG. 43 is an explanatory diagram of test conditions for reproducing the tests shown in FIGS. 39 to 42.
• the light irradiation device 1 includes an information acquisition unit 3 that acquires image information of a part of the user's body that is to be irradiated with light, a control unit 4 that controls the light to be irradiated to the part to be irradiated with light based on unevenness information from the information acquisition unit 3, and a number of light sources 10 (e.g., LEDs) that output light under the control of the control unit 4.
• an information acquisition unit 3 that acquires image information of a part of the user's body that is to be irradiated with light
• a control unit 4 that controls the light to be irradiated to the part to be irradiated with light based on unevenness information from the information acquisition unit 3
• a number of light sources 10 e.g., LEDs
• the information acquisition unit 3 acquires information wirelessly or via wire from, for example, a smartphone as the imaging device 2.
• the information acquisition unit 3 acquires unevenness information regarding the unevenness of the part of the user's body, the face, that is the target of light irradiation.
• the information acquisition unit 3 may also acquire the results of a skin diagnosis.
• the control unit 4 estimates the distance from the light emission surface of the light source 10 to the area to be irradiated with light based on the unevenness information from the information acquisition unit 3, and calculates the optimal irradiation intensity.
• the optimal irradiation intensity is calculated using stored memory information, a predetermined calculation formula, etc.
• the light intensity is controlled by the voltage to the light source 10 and the duty ratio. For example, as shown diagrammatically in Figure 2, the skin diagnosis result is reflected in the control of the light source 10.
• a large number of light sources 10 are evenly provided on the inner surface of the mask 20.
• the multiple light sources 10 can independently emit light simultaneously.
• the mask 20 is made of a plastic housing.
• the mask 20 has an opening 20a that exposes the eyes.
• a headband 21 is attached to the mask 20.
• the headband 21 allows the mask 20 to be attached to and detached from the user's face.
• the mask 20 may be shaped to cover not only the face but also the neck (see also FIG. 36 below). In this case, it is possible to provide care for the neck, which tends to require more care with age.
• each light source 10 When the user wears the mask 20 on their face, the light emission surface of each light source 10 is positioned opposite the area of the user's face that is to be irradiated with light.
• Each light source 10 is composed of multiple types of LEDs to respond to various skin troubles.
• the multiple types of LEDs are green LEDs, red LEDs, blue LEDs, yellow LEDs, etc.
• the multiple types of LEDs may also include invisible light LEDs such as ultraviolet LEDs and infrared LEDs in addition to or instead of visible light LEDs such as green LEDs.
• Green LEDs are effective for melanin suppression and blemish care.
• Red LEDs are effective for wrinkle suppression and sagging suppression.
• Blue LEDs are effective for acne and skin soothing, etc.
• Each light source may be composed of only one type, or multiple types of light sources may be configured to respond to skin troubles and areas. The number of LEDs according to the area may be arranged, or a light source with multiple light-emitting elements integrated into one chip may be used, and the type of light emitted may be changed by control.
• the light source 10 emits light having a central wavelength in the wavelength range of 490 nm to 525 nm. When emitting green light having a central wavelength in the wavelength range of 490 nm to 525 nm, it is effective in suppressing melanin production.
• light is irradiated to the target area with optimal irradiation intensity, making it possible to effectively treat skin problems and the like.
• the optimal irradiation intensity is adjusted according to the area, skin problem, and skin condition.
• the second embodiment will be described.
• the difference from the first embodiment is that the information acquisition unit 3 acquires information on the hue and brightness of the skin color from the image information, and the control unit 4 controls the output or wavelength of the light source 10 based on the information on the hue and brightness of the skin color.
• the hue and brightness of the skin color (brownish dullness, yellowish dullness, blue circles, dark spots, light spots), etc. are determined, and the optimum irradiation intensity and optimum wavelength range are controlled.
• the control may be either the intensity or the wavelength, or both.
• a sensor such as a spot sensor may be installed to detect the color of the skin, and the optimum irradiation intensity and optimum wavelength range may be controlled. For example, an area with many spots may be determined based on the captured image, and the irradiation wavelength and irradiation intensity may be controlled so that the irradiation wavelength and irradiation intensity suitable for spots are realized.
• the functions of the first and second embodiments may be combined to perform measurements and control the irradiation intensity and wavelength range.
• a distance sensor 9 is disposed near each light source 10.
• the distance sensor 9 is a TOF (Time of Flight), an ultrasonic measuring device, a depth image sensor, a laser range finder, or the like.
• the information acquisition unit 3 acquires distance information from each distance sensor 9, rather than information from the imaging device. In other words, the information acquisition unit 3 acquires unevenness information regarding the unevenness of the area to be irradiated with light, based on distance information measuring the distance from the light source 10 to the area to be irradiated with light.
• the control unit 4 controls the light to be irradiated to the area to be irradiated with light, based on the unevenness information (distance information) from the information acquisition unit 3.
• more accurate distance information can be obtained than in the first embodiment, so light can be irradiated to the target area with a more optimal irradiation intensity, making it more effective at treating skin problems and the like.
• more accurate distance information can be obtained than in the first embodiment, it is possible to control the illuminance intensity so that optimal irradiation can be performed for each wavelength region.
• a plurality of light source units 11 are provided on the inner surface of the mask 20.
• a light source 10 is provided in each light source unit 11 so as to be movable. This allows the distance from the light emission surface of the light source 10 to the area to be irradiated with light to be adjusted.
• the light source 10 may be movable along a direction toward or away from the skin, or in a direction intersecting said direction. It may also have a degree of freedom of rotation.
• each light source 10 can be positioned at an optimal position for light irradiation. Therefore, skin troubles and the like can be effectively addressed without adjusting the light intensity of the light source 10 as in the first, second, and third embodiments.
• the light source 10 may be brought closer to the skin than for areas not requiring a relatively strong illuminance intensity. Areas requiring a relatively strong illuminance intensity may be determined based on image information, etc. For example, for areas requiring the melanin production inhibitory effect described below, the light source 10 may be brought closer to the skin than for areas not requiring the same, in order to increase the illuminance intensity of light with a wavelength of 520 nm compared to 450 nm.
• the mask 20A is formed into a soft housing (flexible soft housing) made of silicone rubber or the like. Because it is a soft housing, it can be worn in a state of close contact with the face (target area for light irradiation) 23. If lotion is applied to the face 23, it can be made to fit more closely to the face 23. As shown in Fig. 8, since the inner surface of the mask 20A fits closely to the face 23, the distance from the light emission surface of each light source 10 to the target area for light irradiation can be kept constant regardless of the unevenness of the face. Therefore, for each light source, light is irradiated to the target area for light irradiation at a constant optimal irradiation intensity, and skin troubles and the like can be dealt with more effectively.
• the mask may have a fixing part to keep it in place.
• a dial-type tightening device or a belt made of elastic material may be used.
• Light irradiation may be performed by arranging light sources with multiple wavelength ranges and multiple irradiation intensities, and by sensing, arranging the light sources to provide optimal irradiation.
• an EMS Electro Muscle Stimulation
• microcurrent generator iontophoresis device
• RF Radio Frequency generator
• electrodes must be attached to a mask, etc. This allows electrical stimulation, including DC and AC stimulation, to be applied to the body.
• a microcurrent generator is effective in improving the penetration of beauty ingredients, etc.
• the control unit 4 may obtain optimal output through feedback control based on the analysis results of the skin tester and the image capture device 2.
• the face of the user is the main target of light irradiation, but any part of the user's body can be irradiated with light, and the light can also be applied to the body.
• the light source 10 may be a light source with multiple wavelengths.
• a mask-type device has been described as a representative example, but it may be a wearable type or a tabletop type.
• a tabletop type it may be, for example, set upright on the floor, or placed on a table with the illumination surface formed on the side. It may also be equipped with a sensor that identifies the environment (such as an illuminance sensor), and control may be performed to suppress light irritation to the eyes due to excessive illumination according to the ambient light.
• a sensor that identifies the environment
• control may be performed to suppress light irritation to the eyes due to excessive illumination according to the ambient light.
• the LED illumination is turned on in a completely dark situation, strong light will enter the eyes with open pupils, causing inconvenience such as strain on the eyes. Therefore, by performing this type of control, such inconveniences can be suppressed.
• human faces may be classified into a number of unevenness patterns, and the light intensity and wavelength may be adjusted based on which unevenness pattern the information from the imaging device 2 corresponds to.
• a photo of the human face may be taken with a user terminal such as a smartphone, and sent to a server computer where the unevenness of the face may be analyzed (for example, distinguishing between complexion and blemishes and grasping the facial contours), and the wearing device may control the illuminance according to the distance.
• the user's face pattern may also be divided, and irradiation corresponding to this division may be read from a database and performed.
• the wearing device may be equipped with an adjuster to ensure accurate wearing. By providing an adjuster that allows the device to be worn to fit the target area, irradiation control can be performed more accurately.
• the number of LEDs and LED wavelengths can be pre-adjusted to be optimal for the intended area, and the device can be configured with a mounting surface that can be fine-tuned so that it can be mounted at a uniform distance from the skin surface for optimal irradiation intensity. This makes it possible to receive optimized irradiation without information acquisition or the use of sensors.
• Fig. 10 is an explanatory diagram of the characteristics of light (predetermined light) emitted from a light source (hereinafter referred to as LED 10) 10, with wavelength on the horizontal axis and intensity on the vertical axis, showing an example of the characteristics.
• Fig. 11 is a diagram showing test results relating to the effect of inhibiting melanin production according to the wavelength of light irradiated to the skin.
• Fig. 11 shows test results for cell survival rate, melanin production rate, and melanin production rate per cell when irradiated with LED 10 wavelengths of 450 nm, 520 nm, and 850 nm. Note that in Fig. 11, the control refers to the test result when nothing was irradiated.
• the LED 10 is preferably a light source that generates a predetermined light having a central wavelength in the wavelength range of 490 nm or more and 525 nm or less. Strictly speaking, 505 nm and its vicinity are blue-green wavelengths, and 525 nm and its vicinity are green wavelengths, but hereinafter, the wavelength range longer than 490 nm and equal to or less than 525 nm may be referred to as "green.”
• the specified light has a central wavelength of approximately 505 nm, as shown in FIG. 10. With such a central wavelength, melanin production in the irradiated area of the user's skin can be suppressed more effectively than in the case where the specified light is not irradiated, as described below.
• the specified light can be irradiated in a manner that has a melanin production suppression effect that is 10% or more better than when the specified light is not irradiated in the irradiated area of the user's skin.
• the predetermined light preferably has a half-width at half maximum (see FIG. 10) of ⁇ 20 nm or less, and more preferably about ⁇ 10 nm. This maximizes the effect of suppressing melanin production in the irradiated area of the user's skin.
• the predetermined light is preferably irradiated at a radiation intensity in the range of 0.5 mW/cm 2 or more and 62 mW/cm 2 or less, more preferably at a radiation intensity in the range of 11.5 mW/cm 2 or more and 30 mW/cm 2 or less. Test results regarding this will be described later with reference to FIG. 23 and subsequent figures.
• the predetermined light is irradiated with an irradiation energy in the range of 0.09 J/cm 2 or more and 30 J/cm 2 or less, and more preferably, with an irradiation energy in the range of 0.09 J/cm 2 or more and 11 J/cm 2 or less.
• LED 10 may be combined with other LEDs having other central wavelengths to form a single chip.
• LED 10 and a red LED are combined into a single chip LED, the ratio of the number of green LEDs to red LEDs on one chip may be appropriately adapted.
• FIG. 12 is a diagram showing an outline of a control system to be added to the above-described control system (FIGS. 1 and 5) for the light irradiation device 1. Note that the control system in FIG. 12 may function in various combinations with FIG. 1 and FIG. 5.
• the light irradiation device 1 includes a control device 100, to which a power source 90 and an LED 10 are electrically connected.
• the control device 100 operates based on power from the power source 90 and controls the LED 10.
• the LED 10 operates based on power from the power source 90 under the control of the control device 100.
• the power source 90 may include an external power source and/or an internal power source.
• the internal power source may be a rechargeable battery.
• the control device 100 irradiates the skin with a predetermined light via the LED 10.
• the control device 100 may achieve continuous light irradiation for 1 minute or more, with the irradiation time of the predetermined light accounting for 1/2 or more.
• the control device 100 may also control the emission of light from the LED 10 in one or more operation modes.
• the one or more operation modes may include a predetermined operation mode associated with the melanin production suppression effect, or a predetermined operation mode associated with an effect related to the melanin production suppression effect.
• the control device 100 causes a predetermined light to be output from the head unit in the predetermined operation mode.
• FIG. 13 is a diagram showing an example of the hardware configuration of the control device 100.
• a control target 60 is illustrated in association with the hardware configuration of the control device 100.
• the control device 100 includes a CPU (Central Processing Unit) 11, a RAM (Random Access Memory) 12, a ROM (Read Only Memory) 13, an auxiliary storage device 14, a drive device 15, and a communication interface 17, all connected by a bus 19, as well as a wired transceiver unit 25 and a wireless transceiver unit 26 connected to the communication interface 17.
• a CPU Central Processing Unit
• RAM Random Access Memory
• ROM Read Only Memory
• auxiliary storage device 14 a drive device 15
• a communication interface 17 all connected by a bus 19, as well as a wired transceiver unit 25 and a wireless transceiver unit 26 connected to the communication interface 17.
• the auxiliary storage device 14 is, for example, a HDD (Hard Disk Drive) or an SSD (Solid State Drive), and is a storage device that stores data related to application software (also called “apps") and the like.
• the wired transceiver unit 25 includes a transceiver unit capable of communicating using a wired network.
• a control target 60 is connected to the wired transceiver unit 25. However, some or all of the control target 60 may be connected to the bus 19 or to the wireless transceiver unit 26.
• the wireless transmission/reception unit 26 is a transmission/reception unit capable of communicating using a wireless network.
• the wireless network may include a wireless communication network for mobile phones, the Internet, a VPN (Virtual Private Network), a WAN (Wide Area Network), etc.
• the wireless transmission/reception unit 26 may also include a near field communication (NFC) unit, a Bluetooth (registered trademark) communication unit, a Wi-Fi (Wireless-Fidelity) transmission/reception unit, an infrared transmission/reception unit, etc.
• the control device 100 may communicate with a server (not shown) via the wireless transmission/reception unit 26 to acquire various information.
• the control device 100 may be connectable to a recording medium 16.
• the recording medium 16 stores a specific program.
• the program stored in the recording medium 16 is installed in the auxiliary storage device 14 of the control device 100 via the drive device 15.
• the installed specific program can be executed by the CPU 11 of the control device 100.
• the recording medium 16 may be a recording medium that records information optically, electrically or magnetically, such as a CD (Compact Disc)-ROM, a flexible disk, or a magneto-optical disk, or a semiconductor memory that records information electrically, such as a ROM or a flash memory.
• the recording medium 16 does not include a carrier wave.
• Melanin the pigment that causes pigmentation in the skin, is produced in melanocytes and plays an important role in preventing DNA damage from harmful ultraviolet rays. However, it is also the cause of spots, and there is a high demand for improving this. Therefore, we conducted an experiment to verify the effectiveness of green LED light, which suppresses cellular activity, to see if it also affects melanoma activity and reduces melanin production.
• the melanin production inhibitory effect of green LEDs was evaluated using mouse-derived B164A5 cells (B16 melanoma cells, Riken BRC) and human-derived melanoma cells (HMV-II cells, KAC Co., Ltd.) obtained at Toin University of Yokohama at the request of the university.
• the green LED light source used was Ushio Electric's SMT525 (wavelength 525 nm) and SMT505 (wavelength 505 nm).
• B16 melanoma cells were seeded in a 6-well plate at 1 ⁇ 10 4 and 2 ⁇ 10 4 cells/mL, cultured at 37° C. and 5% CO 2 for 3 days, and then replaced with phenol red-free medium. Green LED irradiation was performed once a day for 3 days, and then cultured for 1 day. Then, Cell Counting Kit-8 (manufactured by Dojindo Laboratories, Inc.) was added and cultured for 3 hours. After culture, the medium was dispensed, the absorbance at 450 nm was measured, and the number of surviving cells was calculated. The higher the absorbance at 450 nm, the higher the number of surviving cells.
• B16 melanoma cells were seeded in a 6-well plate at 1 ⁇ 10 4 and 2 ⁇ 10 4 cells/mL, and after 3 days of culture at 37° C. under 5% CO 2 , the medium was replaced with a phenol red-free medium containing 100 nM of melanin synthesis inducer ⁇ -MSH.
• the cells were washed with 1 mL of PBS (-), dissolved in 2 mol/L aqueous sodium hydroxide solution containing 10 wt% dimethyl sulfoxide (DMSO), and the amount of melanin produced was measured from the absorbance at 405 nm. Furthermore, the amount of cell-derived protein was measured using RC DC (registered trademark) protein assay (manufactured by BioRad). Based on the measurement results, the amount of melanin per amount of cell-derived protein was calculated.
• PBS PBS
• DMSO dimethyl sulfoxide
• the melanin synthesis inducer ⁇ -MSH had a low effect on the proliferation of melanoma cells in HMV-II cells, so theophylline, an MSH enhancer, was used as a melanin synthesis inducer to evaluate HMV-II cells.
• 2 mL of 1 ⁇ 10 4 cells/mL HMV-II cell dispersion was dispensed into a 66-well plate, seeded at 1 ⁇ 10 4 cells/mL, and cultured at 37° C. under 5% CO 2 for 3 days, after which the medium was replaced with 2 mL of phenol red-free medium containing 25 ⁇ L of Theophylline after 40 mM culture.
• the cells were cultured for 1 day, and the cells were dissolved in 2 mol/L aqueous sodium hydroxide solution with 300 ⁇ L of 2 M NaOH solution containing 10 wt% dimethyl sulfoxide (DMSO), and the amount of melanin produced was measured from the absorbance at 405 nm. Furthermore, the amount of cell-derived protein was measured using RC DC (registered trademark) protein assay (manufactured by BioRad). Based on the measurement results, the amount of melanin per amount of cell-derived protein was calculated.
• RC DC registered trademark
• HMV-II cells were seeded at 1 x 10 4 cells/mL in a 6-well plate, cultured at 37°C and 5% CO 2 for 3 days, and then replaced with phenol red-free medium. After 3 days of 505 nm LED irradiation once a day, the cells were cultured for 1 day. Then, Cell Counting Kit-8 (manufactured by Dojindo Laboratories, Inc.) was added and the cells were cultured for 3 hours. After the culture, the medium was dispensed and the absorbance at 450 nm was measured. After the measurement, the survival rate was calculated as a relative value to the absorbance at 450 nm without LED light irradiation.
• FIGS. 23 to 24B show other test results, with FIG. 23 being a table showing the relationship between the radiation intensity of green LED light and the effect (the effect of suppressing melanin production), and FIG. 23A to 24B being graphs showing the relationship between the radiation intensity of green LED light and the effect.
• B16 melanoma 4A5 was provided by Riken BRC.
• the word "cells" used hereafter refers to these.
• the cells and cell culture were performed as described in steps S1 to S3 below, and the following media were used.
• Dulbecco's Modified Eagle Medium (DMEM, Cat No. 10566-016, Gibco, USA) containing 10.0% (v/v) Fetal Bovine Serum (FBS, Cat No. SH30071.03, Hyclone (registered trademark), UK) and 1.0% (v/v) antifungal agent (Antibiotic-Antimycotic 100X, Cat No. 15240-062, Invitrogen, USA) was used.
• Step S2 Irradiation with green LED light The medium was removed, washed with phosphate buffer saline (PBS(-), Cat No.
• Step S3 After washing with PBS after culturing, 2 mL of alamarBlue solution, which was prepared by diluting alamarBlue (registered trademark) (Cat No.
• the alamarBlue solution was collected and placed in a 96-well plate (Cat No. 9017, costar, USA), and the absorbance at 570 nm and 600 nm (OD570, OD600) was measured using a microplate reader (SPARK (registered trademark) 10M, TECAN, Switzerland).
• SPARK registered trademark
• the alamarBlue solution was removed from the 60 mm dish, and after washing with PBS (-), 1 mL of 1 M aqueous sodium hydroxide solution containing 10% DMSO was added to solubilize the melanin, and the mixture was incubated at 85 ° C for 10 minutes. 100 ⁇ L of the melanin solution was placed in a 96-well plate, and the absorbance at 405 nm (OD405) was measured using a microplate reader. The cell viability of the LED application group was calculated by taking the control OD570-600 as 100%. In addition, the melanin production rate was calculated by taking the control and LED irradiation application group OD405 and the OD570-600 measured with alamarBlue as the melanin production rate per cell. A significant difference test was performed using an unpaired t-test between the control and LED application groups. The significance level for both tests was set to less than 5% on both sides.
• the radiation intensity of the predetermined light is preferably in the range of 0.5 mW/cm 2 or more, and more preferably 11.5 mW/cm 2 or more.
• Fig. 24C shows the difference in effect when irradiating green LED light with a wavelength of 520 nm at different radiation intensities.
• the test shown in Fig. 24C was also carried out in the same manner as Fig. 23A and the like.
• the control indicates the test result without any irradiation.
• the test results of 9 mW/ cm2 and 62 W/ cm2 are compared with the control.
• Graphs A, B, and C correspond to cell viability, melanin production rate, and melanin production rate per cell, respectively.
• the radiation intensity of the predetermined light when the radiation intensity of the predetermined light becomes higher than a certain level, the effect does not become significantly large (i.e., it becomes saturated). From these, as described above, it can be said that the radiation intensity of the predetermined light is preferably in the range of 0.5 mW/ cm2 or more and 62 mW/ cm2 or less, and more preferably in the range of 11.5 mW/ cm2 or more and 62 mW/cm2 or less . Also, from the viewpoint of power consumption, it can be said that an upper limit value of about 30 mW/ cm2 is desirable instead of 62 mW/ cm2 .
• the irradiation energy of the predetermined light was in the range of 0.09 J/ cm2 or more and 11 J/ cm2 or less.
• the test was performed with the irradiation energy of the predetermined light in the range of 0.09 J/ cm2 or more and 45 J/ cm2 or less. Effective effects were also confirmed even with a relatively small irradiation energy range of 0.09 J/ cm2 or more and 11 J/ cm2 or less.
• FIG. 24D shows other test results, showing test results when LED light of wavelengths 450 nm, 520 nm, and 850 nm was irradiated.
• FIG. 24D shows test results for cell viability, melanin production rate, and melanin production rate per cell when LED 36 was irradiated with wavelengths of 450 nm, 520 nm, and 850 nm, respectively. Note that in FIG. 24D, the control shows the test results when no light was irradiated.
• test results shown in Figure 24D were conducted by a different institution than the tests described above with reference to Figures 4A and 4B, but the test methods were substantially similar.
• FIG. 24E shows further test results, and is a diagram showing test results relating to the difference in the melanin production suppression effect caused by the difference between three types of wavelengths.
• FIG. 24E shows test results for the melanin production rate per cell when irradiated with LED 36 wavelengths of 505 nm, 525 nm, and 630 nm. Note that in FIG. 24E, the control also shows the test results when nothing was irradiated.
• test results shown in Figure 24E were conducted by a different institution than the tests described above with reference to Figures 4A and 4B, but the test methods were substantially similar.
• Figure 24F shows further test results, and is a diagram showing test results relating to the difference in melanin production suppression effect caused by the difference between four types of wavelengths.
• Figure 24F shows test results for cell survival rate when irradiated with LED 36 wavelengths of 470 nm, 490 nm, 505 nm, and 525 nm. Note that in Figure 24F, the control also shows the test results when nothing was irradiated.
• test results shown in Figure 24F were conducted by a different institution than the tests described above with reference to Figures 4A and 4B, but the test methods were substantially similar.
• the survival rate of B16 melanoma cells was lower at wavelengths of 470 nm, 505 nm, and 525 nm compared to the wavelength of 490 nm.
• the superiority of wavelengths of 470 nm, 505 nm, and 525 nm over the wavelength of 490 nm was demonstrated.
• Fig. 24G shows the test results for the expression level of keratin 10.
• Fig. 24G shows the test results for the expression level of keratin 10 when irradiated with LED 36 at wavelengths of 470 nm, 505 nm, and 590 nm.
• test method is outlined below:
• Step S1 Cell pre-culture Human epidermal keratinocytes (NHEK) were put to sleep in a T-75 flask using a medium, and cultured in a CO2 incubator (5% CO2 , 37°C, humidified). When the cells reached about 80% confluence, they were passaged to a T-225 flask, and cultured until the required number of cells was obtained, and then used for the subsequent test.
• the cell passage method is as follows. After washing the cells with PBS (-/-), the cells were detached using 0.05% Trypsin-EDTA, and trypsin neutralizing solution was added to neutralize trypsin.
• the cell suspension was collected in a centrifuge tube and centrifuged (room temperature, 180 xg, 5 min). The supernatant was removed, new medium was added to suspend the cells, and the number of cells was counted. The cells were suspended to the desired cell density using a medium, and seeded in a culture vessel to be used in the test.
• Step S2 Cell treatment Cells were seeded on a 60 mm dish at 900,000 cells/dish/3 mL. The day after seeding, 5 mL of medium was added, making a total of 8 mL, and device treatment was performed for 30 seconds. Treatment was performed every 24 hours ⁇ 1 hour, and a total of three facial treatments were performed with the facial beauty device. Calcium chloride was added to the medium at the same time as the first device treatment, making the medium 8 mL. Then, treatment was performed for 72 hours.
• Step S4 Quantitative PCR
• the RNA sample was diluted to approximately 100 ng/ ⁇ L before use.
• the RT-PCR reaction was performed under the following conditions: 50°C, 30 min-95°C, 15 min-(94°C, 15 sec-60°C, 60 sec) x 40 cycles.
• the GAPDH gene was used as an internal standard gene.
• the expression level of keratin 10 was significantly greater at a wavelength of 505 nm than at wavelengths of 470 nm and 590 nm.
• the superiority of the wavelength of 505 nm over wavelengths of 470 nm and 590 nm was demonstrated.
• the epidermis is arranged in four layers: the basal layer, the spinous layer, the granular layer, and the stratum corneum.
• turnover occurs in four stages: cell proliferation in the basal layer, keratin (K10) synthesis in the spinous layer, cell death (apoptosis and necrosis) in the granular layer, and cleavage by a proteolytic enzyme (KLK8) in the stratum corneum.
• turnover the process in which epidermal cells are generated in the basal layer, mature as they migrate toward the upper layers, and are formed by exfoliation at the stratum corneum is called turnover.
• keratin 10 is expressed in the spinous layer and is useful in the turnover process due to the mechanism of turnover.
• the expression of keratin 10 suggests that normal turnover is proceeding.
• test results shown in Figures 4A, 4B, and 24D to 24G show that irradiating the skin with light having a central wavelength in the wavelength range longer than 490 nm and equal to or less than 525 nm is more advantageous in terms of the effect of suppressing melanin production and the effect of expressing keratin 10 than irradiating the skin with light having a central wavelength in other wavelength ranges.
• the mask 20B is a wearable type that is worn by the user, and as shown in Figs. 25 and 26, similar to Fig. 7, it is formed in a soft housing made of silicone rubber or the like.
• the mask 20B has a shape that corresponds approximately to the face of a human (e.g., a woman), and the face shape is provided with two openings 20a that expose the eyes, an opening 20b that exposes the nose, an opening 20c that exposes the lips, and two openings 20d that expose the ears.
• the mask 20B is formed in a belt-like shape at the part that covers the back of the head of the human from the outside. By expanding and contracting this belt-like part, it is formed so that it can be attached and detached to the user's face.
• the nose and mouth do not necessarily need to be opened, and may be configured to be able to be irradiated.
• wires W1 to W5 are built into the mask 20B on each side. Note that the wires W1 to W5 are not shown in Figure 26, but are shown in Figures 27 and 29. In Figures 27 and 29, in order to clarify the positional relationship with the face, only the wires W1 to W5 and the cylinders 40a to 40e inside the mask 20B are shown.
• Each wire W1 to W5 passes through each of the cylindrical bodies 40a to 40e fixed to the mask 20B, and both ends of the wires W1 to W5 exposed from within the cylindrical bodies 40a to 40e are guided into a pair of tension adjusters 41 (shown in Figure 26).
• FIG. 27 three of the five wires W1-W5 on each side pass through the central area of the face, and as shown in FIG. 29, two pass through the edge area of the face.
• the upper wire W1 of the three on the central area side passes through a cylinder 40a fixed vertically and horizontally at a position corresponding to the forehead and is led to the tension adjustment device 41 along an almost horizontal direction.
• the middle wire W2 of the three on the central area side passes through a cylinder 40b fixed vertically and horizontally at a position corresponding to the area between the corner of the eye and the lips and is led to the tension adjustment device 41 along an almost horizontal direction.
• the lower wire W3 on the central area side passes through a cylinder 40c fixed vertically and horizontally from the edge of the lip to the chin and is led to the tension adjustment device 41 along an almost horizontal direction.
• the upper of the two wires on the edge area side, W4 passes through a cylinder 40d fixed diagonally at a position corresponding to the edge of the forehead and is led to the tension adjustment device 41 in an almost diagonal upward direction.
• the lower of the two wires on the edge area side, W5 passes through a cylinder 40e fixed vertically between a position above the corner of the eye and a position below the lips and is led to the tension adjustment device 41 in an almost horizontal direction.
• the pair of tension adjusters 41 are attached to the belt-like portion of the mask 20B, that is, the portion that covers the back of the person's head from the outside. By rotating the knob of each adjuster 41, a tension force is applied to the wires W1 to W5, and the amount of rotation of the knob of each adjuster 41 can be used to adjust the tension on the wires W1 to W5.
• the constant distance d is 1 to 15 mm, preferably 3 to 7 mm, and more preferably 5 mm. In this embodiment, the constant distance d is set to 5 mm.
• the half-value angle distance (the distance at which the light intensity is halved) is shortened, but the number of LEDs required for mask 20B increases, and power consumption increases. If the irradiation distance is shortened by 1 mm, the number of LEDs required for mask 20B increases by 180. On the other hand, if the irradiation distance of the LEDs is lengthened, the half-value angle distance increases, but the light intensity of the LEDs decreases in proportion to the square of the distance. If the irradiation distance is increased from 5 mm to 10 mm, the light intensity will be reduced to 1/4 and current consumption will increase. Taking these factors into consideration, in this embodiment, it is set to 5 mm.
• the spacer 43 is formed in a conical shape with a cross-sectional area that increases as it approaches the skin surface 42.
• the shape of the spacer 43 may be cylindrical, prismatic, or wavy, and is not critical.
• the spacer 43 is a light-transmitting member. It is preferable that the spacer 43 is formed from, for example, an elastic material that does not feel unnatural when in contact with the skin surface 42.
• the mask 20B uses both the wires W1 to W5 and the spacer 43, but it may use only one of these configurations. In addition, various arrangements and numbers of the wires W1 to W5 are possible.
• each LED 10A and 10B is configured to emit blue-green light (wavelength 490 nm to 525 nm), red light (wavelength 615 nm to 655 nm), and yellow light (wavelength 570 nm to 610 nm) that have the skin effect described above.
• LEDs 10A and 10B are arranged in a soft housing of a wearable mask 20B worn by the user, and are arranged facing each other with respect to the skin surface 42. As shown in FIG. 33, LEDs 10A and 10B are composed of two types of LEDs: a plurality of LEDs (first light source) 10A arranged at equal intervals in the two-dimensional direction, and an LED (second light source) 10B arranged at the center position of four LEDs adjacent in the two-dimensional direction. The interval between adjacent LEDs 10A in the two-dimensional direction is set to twice the half-value angle distance (the distance at which the light intensity is halved) of LED 10A. LED 10B is smaller in size and has lower output than LED 10A.
• the distance d between LED 10A, LED 10B and skin surface 42 is set to 5 mm, so the distance between adjacent LEDs 10A in the two-dimensional direction is set to 20 mm, which is twice the half-value angle distance.
• the distance between adjacent LEDs 10B in the two-dimensional direction is also set to 20 mm.
• LED 10B in addition to LED 10A will be explained with reference to FIG. 34.
• FIG. 34 if two adjacent LEDs 10A are L1 and L2, the light intensity distribution of both will theoretically be as shown in FIG. 34(a).
• the light intensity between the two LEDs is 1.0:0 at L1 and L2, and 0.5:0.5 at the intermediate half-value angle distance, and is kept uniform in the section between L1 and L2.
• the light intensity of L2 (or L1) is not 0 near L1 (or L2) and has a weak light intensity.
• LED 10B which is smaller in size and has a lower output than LED 10A, is placed in the middle position between L1 and L2 where light unevenness occurs, to complement the light intensity and make the light illumination in the section between L1 and L2 uniform.
• the wires W1 to W5 ensure close contact with the skin, and the spacer 43 maintains a constant distance d between the LEDs 10A and 10B and the skin surface 42, so that the distance d between the LEDs 10A and 10B and the skin surface 42 is a constant value (5 mm) over almost the entire area, and optimal light output can be output evenly to the constant distance d, allowing suitable light irradiation to be performed on the skin surface 42 with the expectation of various effects, such as cosmetic effects.
• Figure 35 shows a comparison of the light output, etc., between an arrangement in which only LED 10A is arranged (arrangement equivalent to the comparative example) and an embodiment in which LED 10A and LED 10B are arranged. As shown in Figure 35, it was shown that the maximum light output can be kept lower in the embodiment in which LED 10A and LED 10B are arranged, compared to an arrangement in which only LED 10A is arranged (arrangement equivalent to the comparative example).
• the LED with green light output is preferably irradiated with a wavelength of 505 nm and a radiation intensity of 11 mW/cm 2 to 44 mW/cm 2. As described in detail above, this is because it has been proven that it has a high effect of suppressing melanin production.
• the LED with yellow light output is preferably irradiated with a wavelength of 590 nm and an output target value of 18 mW/cm 2. This is because it has been proven that this value promotes collagen production and promotes skin turnover.
• the LED with red light output is preferably irradiated with a wavelength of 635 nm and an output target value of 50 mW/cm 2. This is because it has been proven that this value is suitable for increasing hyaluron production.
• FIG. 36 shows an application example of the embodiment described above.
• a neck cover 45 is provided in addition to the mask 20B of the embodiment described above.
• the neck cover 45 is also formed in the same configuration as the mask 20B. Therefore, in this application example, various effects such as beauty effects can be expected not only for the skin on the user's face but also for the skin on the neck.
• the soft three-dimensional mask type of Figures 38 (a) and (b) is fixed by wrapping it around the face and irradiates light, but there is a problem that the irradiation distance varies around the nose and the edge of the face (chin) where it is in close contact, and it cannot follow the unevenness of the user's face and cannot maintain a constant distance.
• the soft mask is three-dimensionally shaped to fit the face and is designed to keep the skin at a constant distance, providing more optimal irradiation to the skin.
• the device can be configured to suit the part and shape, allowing for more optimized irradiation treatment. If the wavelength, optimal irradiation, output, and distance to the skin surface differ depending on the part and shape, it is desirable to configure the mask to suit the preferred implementation. For example, since the skin around the eyes is thin and weak, it is preferable to use a mask with low output and irradiate from a close distance, and for parts with noticeable pores such as the nose and cheeks, it is preferable to irradiate evenly and from a slightly distant wide surface with a slightly stronger irradiation intensity.
• the LED arrangement needs to be suitable for irradiation according to the characteristics, rather than uniform irradiation, and the spacer needs to be adjusted and configured to maintain the irradiation distance according to the part.
• the spacer needs to be adjusted and configured to maintain the irradiation distance according to the part.
• the light irradiation device 1 may irradiate light from the above-mentioned green LED onto the dry skin of the user, but may also irradiate light from the green LED onto skin to which a gel or liquid containing the substance to be permeated has been applied.
• the substance to be permeated may be any substance.
• the substance may be a substance that can be applied to human skin, and may typically be a substance that is expected to have various effects, such as cosmetic effects.
• the high-density arrangement area refers to an area where LEDs 10A, 10B are arranged at a high density in a manner that achieves the "uniformity" described below.
• the multiple LEDs 10A, 10B are arranged in the high-density arrangement area so that the output acting on the user's skin is uniform.
• the multiple LEDs 10A, 10B are arranged so that the output acts uniformly across the target skin range.
• "uniform” refers to a state in which, among the levels of the output acting across the target skin range, the range in which the output level is 0.5 or higher, when the maximum value of the output level acting across the target skin range is 1, accounts for 70% or more of the target skin range.
• FIG. 39 is a diagram showing the results of evaluation (test results) of the variation in the output of a plurality of LEDs 10A, 10B in a high-density arrangement region according to this embodiment.
• the output (irradiation intensity) for a rectangular region corresponding to the target skin range is shown by hatching in the form of a distribution of absolute values.
• the irradiation intensity corresponding to each hatched region is as shown in the legend in the figure.
• the output (irradiation intensity) for a rectangular region corresponding to the target skin range is shown by hatching in the form of a distribution of relative values.
• the irradiation intensity corresponding to each hatched region is as shown in the legend in the figure.
• the relative value is a relative value when the maximum value of the irradiation intensity is set to 1.
• the maximum value (peak) of the irradiation intensity is 11.4 mW/cm 2 , which satisfies the desirable range of 11.0 mW/cm 2 or more described later.
• Figures 40 and 41 show the results of the test shown in Figure 39 with respect to the difference in distance d from the skin surface 42. Specifically, in the test shown in Figure 39, the distance d from the skin surface 42 is 7 mm, whereas in the tests shown in Figures 40 and 41, the distance d from the skin surface 42 is 5 mm and 10 mm, respectively.
• the maximum value (peak) of the irradiation intensity is as large as 13.6 mW/ cm2 as shown in Fig. 40, but as can be seen from the test results related to the relative values on the lower side, the variation in irradiation intensity is significantly large. Specifically, when the maximum value is set to 1, the range where the output level is from 0.4 to 0.6 becomes relatively wide.
• the maximum value (peak) of the irradiation intensity is 8.66 mW/cm 2 , which is insufficient.
• the distance d from the skin surface 42 is preferably within the range of 7 mm or its vicinity.
• FIG. 42 is an explanatory diagram of test results showing the usefulness of LED 10B, of the multiple LEDs 10A and 10B described above.
• the top and bottom of the left side (case 1) show test results relating to a configuration in which LED 10B is not present, of LEDs 10A and 10B, and the top and bottom of the right side (case 2) show test results relating to this embodiment in which both LEDs 10A and 10B are provided.
• the top and bottom of each represent the absolute value evaluation and relative value evaluation described above, and their meanings are as described above.
• FIG. 42A This effect can be inferred from the principle shown in FIG. 42A, which corresponds to FIG. 34 described above.
• FIG. 42A if two adjacent LEDs 10A are L1 and L2, the light intensity distribution of both is theoretically as shown in FIG. 42A (a).
• the LEDs are arranged at the half-value angle distance of the LEDs, the light intensity between the two LEDs is 1.0:0 at L1 and L2, and 0.5:0.5 at the intermediate half-value angle distance, and is kept uniform in the section between L1 and L2.
• the light intensity of L2 (or L1) is not 0 near L1 (or L2) and has a weak light intensity, as shown in FIG.
• an LED 10B (indicated as L3 in Figure 42A) that is smaller in size and has a lower output than LED 10A is placed in the middle position between L1 and L2 where the uneven light occurs. This complements the light intensity and makes it possible to make the light intensity uniform in the section between L1 and L2.
• LED 10A instead of LED 10B at the midpoint between L1 and L2, but in this case, the light intensity directly below L1 and L2 will increase, and the maximum value (peak) of the irradiation intensity may become excessive, or the desired uniformity may not be achieved.
• the board needs to have mounting areas for multiple other LEDs, and free space for spacers 43 to abut, etc. Therefore, it may not be possible to arrange LEDs 10A, which require a relatively large mounting area, in a dense arrangement.
• the relatively small LED 10B requires only a relatively small mounting area, and is therefore suitable for mounting in a high-density arrangement area.
• the relatively small LED 10B requires only a relatively small mounting area, and is therefore suitable for mounting in a high-density arrangement area.
• the small red LED is also arranged in the center of the area formed by four adjacent large red LEDs in the high-density arrangement area. This similarly makes it possible to equalize the output of the red LED over the target skin area facing the high-density arrangement area and to easily secure a space for the spacer 43 to abut.
• the red LED preferably has a peak output of 10 mW/cm2 or more when the distance d from the skin surface 42 is 7 mm.
• the red LED, together with the infrared LED preferably has a peak output of 50 mW/ cm2 or more when the distance d from the skin surface 42 is 7 mm.
• the small yellow LED is also arranged in the center of the area formed by four adjacent large yellow LEDs in the high-density arrangement area. This similarly makes it possible to equalize the output of the yellow LEDs over the target skin area facing the high-density arrangement area, and to easily secure a space for the spacer 43 to abut.
• the yellow LED preferably has a peak output of 5 mW/cm2 or less , and more preferably has a peak output of 10 mW/ cm2 or less, when the distance d from the skin surface 42 is 7 mm.
• Figure 43 is an explanatory diagram of the test conditions for reproducing each test shown in Figures 39 to 42 above.
• a plan view of the test device 5 is shown at the top, and a side view of the test device 5 is shown at the bottom.
• the test device 5 includes an XY stage 500 and a Z stage 520.
• the Z stage 520 is movable in three axial directions relative to the XY stage 500, and its height H11 in the Z direction relative to the XY stage 500 is adjustable.
• the arrow R11A corresponds to the Z direction corresponding to the up-down direction
• the arrow R11B corresponds to the X direction perpendicular to the Z direction
• the Y direction (not shown) corresponds to the direction perpendicular to the paper surface (XZ plane).
• the test object 510 is placed on the XY stage 500.
• the test object 510 is a substrate (e.g., a flexible substrate on which the LEDs 10A and 10B are mounted) in the high-density arrangement area of the light irradiation device 1.
• the substrate is laid out flat on the XY stage 500 with the back side of the mask facing up.
• the substrates may be placed separately in order so that the same positional relationship as in the product state is reproduced.
• a rubber sheet with spacers may be used instead of the back side of the mask.
• the height of the spacers may be set to a height corresponding to the distance d from the skin surface 42, and the material of the rubber sheet may have the same characteristics (light transmission characteristics) as the back side of the mask, for example, silicone rubber.
• a light intensity measuring device (light power meter) 530 is attached to the Z stage 520.
• the light intensity measuring device 530 may be, for example, a spectrometer from Hangzhou Hopoo Light & Color Technology Co., Ltd.
• the Z stage 520 is adjusted for each measurement point, and the light receiving sensor of the light intensity measuring device 530 is set so that it touches the back side of the mask (or the surface of the rubber sheet).
• the measurement points are set in a measurement range (for example, a 20 x 20 mm range) and may be moved at a predetermined pitch (5 mm pitch). In this case, the measurement range and the predetermined pitch may be set so that the LED 10A is located at the center of the measurement range.
• the number of measurement points may be set so that the entire high-density arrangement area is covered depending on the size of the high-density arrangement area.
• the measurement results are visualized (for example, graph processing in Excel that colors the squares) as in the test results shown in Figures 39 to 42 above, and may be evaluated in two ways: absolute values and relative values to the maximum value.
• the action source was an LED, but it is also possible to use action sources that act without physical contact, such as irradiation using various light sources, plasma discharge, and wind.
• a light irradiation device comprising: a control unit that controls the light to be irradiated to the light irradiation target site or controls a position of the light source based on the unevenness information from the information acquisition unit.
• the information acquisition unit acquires skin color hue and brightness information from the image information, and the control unit controls the output or wavelength of the light source based on the skin color hue and brightness information.
• the light source is characterized in that it irradiates light having a central wavelength in the wavelength range of 490 nm or more and 525 nm or less.
• the light sources are arranged facing the multiple light irradiation target areas, and the multiple light sources are capable of independently irradiating light simultaneously.
• the light source is a wearable type that is worn by the user, or a tabletop type that is installed in a predetermined positional relationship with the user.
• a diffusion member (lens, sheet with diffusion effect) may be provided between the light source and the skin surface to further enhance uniformity.
• the device may be possible to design the device to irradiate the face or other parts of the body (neck, beaulleté, back, etc.), and to make it easier to operate when worn, it may be designed so that the controller is worn around the neck, or the battery is integrated into the controller and worn on the shoulder.
• Light irradiation device 2 Imaging device (smartphone) 3 Information acquisition unit 4 Control unit 10 Light source 10A LED (first light source) 10B LED (second light source) 9 Distance sensor 20, 20A Mask 41 Tension adjuster 42 Skin surface 43 Spacer W1 to W5 Wires

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• 2023
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