WO2023280636A1 - Produit de soin et de protection de la peau, et de désinfection de plaies, toléré par la peau, à appliquer sur la peau - Google Patents

Produit de soin et de protection de la peau, et de désinfection de plaies, toléré par la peau, à appliquer sur la peau Download PDF

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Publication number
WO2023280636A1
WO2023280636A1 PCT/EP2022/067730 EP2022067730W WO2023280636A1 WO 2023280636 A1 WO2023280636 A1 WO 2023280636A1 EP 2022067730 W EP2022067730 W EP 2022067730W WO 2023280636 A1 WO2023280636 A1 WO 2023280636A1
Authority
WO
WIPO (PCT)
Prior art keywords
skin
cream
agent according
carrier matrix
gel
Prior art date
Application number
PCT/EP2022/067730
Other languages
German (de)
English (en)
Inventor
Rainer Pommersheim
Denis Breuch
Holger LÖWE
Original Assignee
TULICHEM GmbH
Merlin Apotheke Ruth Gebhardt Und Dr. Frank Ullrich Ohg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TULICHEM GmbH, Merlin Apotheke Ruth Gebhardt Und Dr. Frank Ullrich Ohg filed Critical TULICHEM GmbH
Publication of WO2023280636A1 publication Critical patent/WO2023280636A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the invention relates to a skin-friendly, caring and protective as well as a wound disinfectant for application to the skin or for treating it, containing one or more active substances, in particular, but not exclusively, plant extracts or oils and a carrier matrix according to the preamble of claim 1.
  • Products which can be applied to the skin and in which application to the skin results in a caring, but also a disinfecting, germ-reducing effect.
  • These preparations are based on the active ingredients isopropanol, ethanol or other alcohols.
  • the utility model DE 20 2020 104 615 Ul is a disinfecting, skin-friendly, caring and moisturizing agent for application to the skin.
  • the agent has one or more disinfecting active ingredients and is characterized in that water-soluble chlorine derivatives and/or an alcohol are incorporated into a base matrix and additionally containing a mixture of substances for odor masking of the special disinfecting materials.
  • a cream or lotion is an oil-in-water emulsion or water-in-oil emulsion that makes the ingredients ready for application.
  • Creams are less viscous than ointments, i.e. more liquid, and are easily absorbed by the skin.
  • Emulsifiers or emulsion stabilizers are often used in creams. In general usage, they are increasingly also referred to as non-medical, i.e. purely care products. In the case of currently commercially available products which can be applied to the skin, the manufacturer often promises a beneficial effect. Such products usually contain mixtures of vegetable oils or extracts, which have a physiological effect. Preparations that contain cannabidiols (CBD) as ingredients have also become known.
  • CBD cannabidiols
  • Examples of such products are the Bioturm natural cosmetics CBD ointment, Wobcare CBD active cream, Rubaxx cannabis CBD gel, Venostasin gel or the comfrey cream from the Benedictine Association of Beuron e.V.
  • the corresponding active ingredients or a combination of active ingredients are only offered in a single dosage form, for example as an ointment, gel or cream.
  • the aim of the invention is therefore to create a quasi modular system with which it is possible to react flexibly and quickly to corresponding customer requirements.
  • the object of the invention is achieved by a skin-friendly, caring and protective and disinfecting agent according to claim 1, the dependent claims representing at least expedient configurations and developments.
  • a stored active substance starting base mixture is placed in a carrier matrix integrated.
  • the carrier matrix is designed either as a cream, lotion or ointment, as a gel matrix or as an alcoholic cream.
  • the cream can be made water-based or fat-based.
  • the alcoholic cream is a combination of an alcoholic gel and a fat-based cream.
  • Functional additives can be added to the active substance starting base mixture.
  • Such functional or ancillary materials may include fragrances, dyes, odor masking materials, fillers, thickeners, humectants, and/or ultraviolet shielding agents.
  • alum As a means of quickly closing wounds, e.g. B. alum is used.
  • This agent can be combined with an analgesic component, e.g. B. Polidocanol can be combined.
  • a cannabidiol (CBD) isolate in gel form or a mixture of herbal oils enriched with CBD as a cream is also effective in this regard.
  • the carrier matrix can be based on a commercially available base cream or hydrophilic ointment.
  • the carrier matrix can also contain hydrophilic gel or a lipophilic gel.
  • the active substance starting base mixture contains, for example, cannabidiol, essential oils and/or plant isolates.
  • the skin-friendly, caring and protective agent can be used as a cream or ointment based on fats or oils, as a gel based on water and/or alcohol, as an alcoholic cream, which has both a high fat and or oil content and at the same time has a high alcohol content.
  • the respective agent therefore consists at least of the carrier matrix, the active substances and additional substances that can have a functional effect and are selected depending on the intended application.
  • These functional or complementary additives can be fragrances or dyes, but also substances for masking odors or fillers, including substances such as flair, for example, to achieve an additional moisturizing effect.
  • UV absorbers or UV blockers can be added if there is a desire to use the agent as UV protection.
  • the carrier matrix can simply be exchanged or the carrier matrix can be varied while retaining the active substances and the selected functional or additional additives.
  • creams are agents based on oil and water.
  • Water-based creams are oil-in-water emulsions.
  • Fat-based creams are water-in-oil emulsions.
  • An oil-in-water cream can achieve a cooling effect.
  • Ointments are fat-based substances which, unlike creams, do not contain any water according to the pharmaceutical definition, but are able to absorb water depending on their composition.
  • a gel is defined here as a finely dispersed system consisting of at least one solid and one liquid phase.
  • the solid phase for example a polymer, forms a spongy, three-dimensional network, the pores of which can be filled with a liquid, for example an alcohol and/or water or a gas. Both phases penetrate each other completely.
  • Alcoholic creams are formulations that contain fats and water, similar to a conventional cream, but also have a high alcohol content.
  • the alcoholic creams used here according to the invention are a combination of an alcoholic gel with a fat-based cream, with higher alcohol contents of up to 70% and more being achievable, resulting in an improved disinfecting effect.
  • the skin-friendly, caring and protective agent according to the invention consists of the following substances or components:
  • the carrier matrix consists of different substances or is structured differently, as follows: a. Carrier matrix as a cream or ointment:
  • Base Cream DAC Glycerol Monostearate 60, Cetyl Alcohol, Medium Chain Triglycerides (Neutral Oil, Miglyol 812), White Vaseline, Macrogol-20- glycerol monostearate., Propylene Glycol, Purified Water.
  • Lanolin DAB composed of wool wax, purified water and extra virgin olive oil.
  • Hydrophilic base emulsion DAC composed of sorbitan monostearate, type I, macrogol-8-stearate, type I, glycerol 85%, medium-chain triglycerides, citric acid, potassium sorbate, purified water.
  • Hydrophobic base cream DAC composed of triglycerol diisostearate, isopropyl palmitate, paraffin oil, polyethylene, potassium sorbate, citric acid, magnesium sulfate, glycerol 85%, purified water.
  • Hydrophilic ointment DAB consisting of viscous paraffin, vaseline, emulsifying cetostearyl alcohol.
  • Carrier matrix as gel consisting of viscous paraffin, vaseline, emulsifying cetostearyl alcohol.
  • the gel matrix can be a hydrophilic gel, for example consisting of gel formers such as carbomers, cellulose derivatives such as e.g. hydroxyethyl cellulose, carboxymethyl cellulose, hydroxypropylmethyl cellulose or methyl cellulose, or polysaccharides such as e.g. alginate, agar, xanthan,
  • Lipophilic gels are also possible as a matrix, for example consisting of viscous paraffin with the addition of polyethylene or neutral oils with thickeners such as zinc stearate, aluminum stearate, highly disperse silicon dioxide or ethyl cellulose.
  • Carrier matrix as alcoholic cream for example consisting of viscous paraffin with the addition of polyethylene or neutral oils with thickeners such as zinc stearate, aluminum stearate, highly disperse silicon dioxide or ethyl cellulose.
  • a hydrogel can serve as a basis here, for example consisting of carbomer or another of the substances mentioned in lb, purified water and ethanol in which a neutral oil or an emulsion such as a base cream according to item 1.a. or another cream or ointment has been incorporated.
  • CBD Cannabidiol
  • CBD oils, extracts or isolates in combination with e.g. menthol and camphor are also worth mentioning.
  • Formulations without cannabidiol are also possible, such as: Essential oils, alcoholic extracts and isolates from anise, arnica, cayenne pepper, frankincense, caraway, cloves, cinnamon, eucalyptus, fennel, lavender, lemon, chamomile, tea tree, lemon balm, arnica , flanf, St. John's wort, spruce, pine needles, rosemary, thyme, etc., and combinations thereof.
  • CBD cannabidiol
  • Dyes can be ß-carotene, riboflavin, carmine, curcurmine, azorubine, patent blue V, gold, titanium dioxide, iron oxides, mica b. Fragrances:
  • the invention relies on commercially available mixtures of substances that serve to mask odors.
  • the composition of two such products is given as an example, as can be seen from the manufacturer's data sheet:
  • Hexyl salicylates 3,7-dimethyloctan-3-ol, l-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethane-l -one , 2H-Pyran-4-ol, tetrahydro-4-methyl-2-(2-methylpropyl)- , Benzenepentanol, beta-methyl- ,Benzenepropanol, beta.,3-trimethyl-, Pentadecan-15-olide, 2 ,6-dimethyloct-7-en-2-ol, a-methyl-1,3-benzodioxole-5-propionaldehyde, 4-(4-methyl-3-pentenyl)cyclohex-3-ene-1-carbaldehyde, (E )-anetholes, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopentenl-yl
  • the product has an additional moisturizing effect.
  • a UV blocker such as titanium oxide
  • it can be used for sun protection.
  • the sun protection factor is given by the concentration of titanium oxide.
  • an additional amount of an alcohol for example ethanol, can be added to the mixture in proportions of more than 70%. This achieves a germicidal effect.
  • the ready-to-sell agent for application to the skin consists of the components described above in different mixing ratios. In any case, it must contain components 1 and 2 and, if necessary, 3.
  • the agent according to the invention can be provided and offered in appropriate containers or packaging. Dispensers, cans, tubes or the like are used for this purpose.
  • the agent according to the invention is particularly preferably intended for use as a hand cream and is applied to the skin in the classic manner by rubbing it in, which results in the desired caring or disinfecting effect.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne un produit de soin et de protection de la peau, et de désinfection de plaies, toléré par la peau, à appliquer sur la peau ou destinée au traitement de celle-ci, présentant une ou plusieurs substances actives, en particulier mais non exclusivement, des extraits végétaux ou des huiles végétales, ainsi qu'une matrice de support. Selon l'invention, un mélange de base de départ à substance active en réserve est intégré à la matrice de support selon la forme de d'administration et d'application souhaitée, la matrice de support se présentant au choix sous la forme d'une crème, d'une lotion ou d'une pommade, sous la forme d'une matrice de gel ou sous la forme d'une crème alcoolisée.
PCT/EP2022/067730 2021-07-05 2022-06-28 Produit de soin et de protection de la peau, et de désinfection de plaies, toléré par la peau, à appliquer sur la peau WO2023280636A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE202021103593.5U DE202021103593U1 (de) 2021-07-05 2021-07-05 Hautverträgliches, pflegendes und schützendes Mittel zum Auftragen auf die Haut
DE202021103593.5 2021-07-05

Publications (1)

Publication Number Publication Date
WO2023280636A1 true WO2023280636A1 (fr) 2023-01-12

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2022/067730 WO2023280636A1 (fr) 2021-07-05 2022-06-28 Produit de soin et de protection de la peau, et de désinfection de plaies, toléré par la peau, à appliquer sur la peau

Country Status (2)

Country Link
DE (1) DE202021103593U1 (fr)
WO (1) WO2023280636A1 (fr)

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1955591A1 (fr) 2007-01-09 2008-08-13 Painless Tech GbR Produit de soin et traitement antimicrobien de la peau
AT509000A1 (de) * 2009-10-23 2011-05-15 Rausch Peter Wasserlösliche zubereitungen von cannabinoiden und cannabispräparaten und deren anwendungen
US20170042791A1 (en) * 2015-08-11 2017-02-16 KannaInnovations LLC Topical compositions comprising hydroxy acids and cannabinoids for skin care
EP3251668A1 (fr) * 2016-06-02 2017-12-06 Pharmotech SA Compositions de cannabidiol et leurs utilisations
CN107811904A (zh) * 2017-10-27 2018-03-20 云南汉木森生物科技有限责任公司 抗炎祛斑雪花膏及其制备方法
CA2971197A1 (fr) * 2017-06-20 2018-12-20 One World Cannabis Ltd Extraits de cannabis et formulations topiques destines a une utilisation pour des problemes cutanes
US20200197359A1 (en) * 2018-09-17 2020-06-25 Cody D. Freeze Cannabinoid and Terpene-Infused Topical Cream
DE202020104277U1 (de) * 2020-06-30 2020-08-11 Merlin Apotheke am Hochhaus Ruth Gebhardt & Dr. Frank Ullrich OHG Desinfizierendes, hautverträgliches, pflegendes Mittel zum Auftragen auf die Haut
DE202020104615U1 (de) 2020-07-24 2020-08-19 Merlin Apotheke am Hochhaus Ruth Gebhardt & Dr. Frank Ullrich OHG Desinfizierendes, hautverträgliches, pflegendes und rückfettendes Mittel zum Auftragen auf die Haut
US20200345657A1 (en) * 2019-05-02 2020-11-05 Betterlife Pharma Inc. Cannabinoid stock for formulation products
WO2022016160A1 (fr) * 2020-07-17 2022-01-20 India Globalization Capital, Inc. Composition à base de cannabidiol (cbd) et méthode de traitement de la douleur
WO2022159614A1 (fr) * 2021-01-20 2022-07-28 Therabody, Inc. Formulations stables de mélanges d'huiles de cannabinoïdes organiques

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1955591A1 (fr) 2007-01-09 2008-08-13 Painless Tech GbR Produit de soin et traitement antimicrobien de la peau
AT509000A1 (de) * 2009-10-23 2011-05-15 Rausch Peter Wasserlösliche zubereitungen von cannabinoiden und cannabispräparaten und deren anwendungen
US20170042791A1 (en) * 2015-08-11 2017-02-16 KannaInnovations LLC Topical compositions comprising hydroxy acids and cannabinoids for skin care
EP3251668A1 (fr) * 2016-06-02 2017-12-06 Pharmotech SA Compositions de cannabidiol et leurs utilisations
CA2971197A1 (fr) * 2017-06-20 2018-12-20 One World Cannabis Ltd Extraits de cannabis et formulations topiques destines a une utilisation pour des problemes cutanes
CN107811904A (zh) * 2017-10-27 2018-03-20 云南汉木森生物科技有限责任公司 抗炎祛斑雪花膏及其制备方法
US20200197359A1 (en) * 2018-09-17 2020-06-25 Cody D. Freeze Cannabinoid and Terpene-Infused Topical Cream
US20200345657A1 (en) * 2019-05-02 2020-11-05 Betterlife Pharma Inc. Cannabinoid stock for formulation products
DE202020104277U1 (de) * 2020-06-30 2020-08-11 Merlin Apotheke am Hochhaus Ruth Gebhardt & Dr. Frank Ullrich OHG Desinfizierendes, hautverträgliches, pflegendes Mittel zum Auftragen auf die Haut
WO2022016160A1 (fr) * 2020-07-17 2022-01-20 India Globalization Capital, Inc. Composition à base de cannabidiol (cbd) et méthode de traitement de la douleur
DE202020104615U1 (de) 2020-07-24 2020-08-19 Merlin Apotheke am Hochhaus Ruth Gebhardt & Dr. Frank Ullrich OHG Desinfizierendes, hautverträgliches, pflegendes und rückfettendes Mittel zum Auftragen auf die Haut
WO2022159614A1 (fr) * 2021-01-20 2022-07-28 Therabody, Inc. Formulations stables de mélanges d'huiles de cannabinoïdes organiques

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