WO2023134420A1 - 一种水苏与石斛复方口服液及其制备方法 - Google Patents

一种水苏与石斛复方口服液及其制备方法 Download PDF

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WO2023134420A1
WO2023134420A1 PCT/CN2022/141092 CN2022141092W WO2023134420A1 WO 2023134420 A1 WO2023134420 A1 WO 2023134420A1 CN 2022141092 W CN2022141092 W CN 2022141092W WO 2023134420 A1 WO2023134420 A1 WO 2023134420A1
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dendrobium
stachys
oral liquid
compound oral
spleen
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PCT/CN2022/141092
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English (en)
French (fr)
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姜雪萍
陈乃富
韩邦兴
应凤兰
张嗣波
钱珍珍
赵艳丽
王振南
李跃
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皖西学院
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Priority to ZA2023/02883A priority Critical patent/ZA202302883B/en
Publication of WO2023134420A1 publication Critical patent/WO2023134420A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A61K36/8984—Dendrobium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the invention relates to an oral liquid, in particular to a compound oral liquid of stachyus and dendrobium and a preparation method thereof.
  • Stachys is a perennial herb of the family Lamiaceae. Plants 20-80 cm tall, with rhizomes that grow fibrous roots at nodes. Stems simple, erect, quadrangular, grooved, with small setae on ribs and nodes, rest glabrous.
  • Dendrobium also known as Immortal Dendrobium Orchid Rhyme, Immortal Grass, Resurrection Grass, Ziying Xianzhu, Chlorophytum, Linlan, Forbidden Life, etc.
  • the stem is erect, fleshy and thick, slightly flattened cylindrical.
  • the object of the present invention is to provide a stachys and dendrobium compound oral liquid and a preparation method thereof, aiming at the problem of poor therapeutic effect of drugs and reluctance to take drugs proposed in the above prior art.
  • a compound oral liquid of stachyus and dendrobium comprises components and mass ratios: 5-20g of stachyus, 2-10g of dendrobium, 2-10g of jujube, 1-5g of poria cocos, 1-5g of Chinese yam 4g, tangerine peel 1-5g, bacillus licheniformis powder 1-5g, bifidobacterium powder 1-5g.
  • stachys include dried rhizomes of stachys and fresh rhizomes of stachys
  • dendrobium includes Dendrobium Huoshanense and Dendrobium officinale.
  • a preparation method of stachyus and dendrobium compound oral liquid comprising the following steps:
  • Step 1 Take a certain amount of dendrobium, crush it in a mortar, and set aside.
  • Step 2 Take stachyus, jujube, Poria cocos, yam, and tangerine peel, mix them with the dendrobium in step 1, put them into a container for decoction, add 2-10 times the amount of water for the first time, and add them for the second time after decocting for 2.5 hours. 2-6 times the amount of water, after decocting for 1 hour, add 2-6 times the amount of water for the third time, filter, and combine the decoction.
  • Step 3 the decoction is concentrated until a solution is obtained.
  • Step 4 Pour the concentrated solution of Step 3 into a centrifuge, take the supernatant, and set aside.
  • Step 5 Add stachyose to the supernatant in Step 4, stir evenly to obtain a mixed solution, and adjust the pH value of the mixed solution to 4.5-5.5.
  • Step six filling.
  • Step seven sterilization treatment.
  • Step 9 packaging and labeling, and refrigerating the packaged finished product.
  • the temperature of the water added in the second step is 50-100°C.
  • the relative density of the solution obtained in the third step is 1.0198-1.0411, and the relative crude drug content is 0.75-1.0 g/ml.
  • the centrifugal speed of the centrifuge is 3500-4000r/min, and the centrifugation time is 10-20min.
  • the amount of stachyose added to the supernatant in the step five is 1g/100ml-2g/100ml.
  • the temperature of the sterilization treatment in the step 7 is 115-121° C., and the time is 10-20 minutes.
  • Dendrobium oral liquid of the present invention the oral liquid is easier to be absorbed by patients than pills, and is easy to take.
  • This application is mainly for invigorating qi and invigorating the spleen, and can also regulate qi and eliminate food, moisten the intestines and relieve constipation. It is used to regulate spleen and stomach weakness, spleen deficiency and constipation.
  • Bifidobacteria can promote intestinal peristalsis, prevent constipation, and improve immunity.
  • Bacillus licheniformis is an intestinal probiotic, which can improve intestinal flora imbalance and promote intestinal While peristalsis, it can also invigorate the spleen and qi;
  • the preparation method of Dendrobium oral liquid of the present invention is mainly Chinese medicinal materials of the same origin as medicine and food, without any additives, on the basis of retaining the characteristics of traditional Chinese medicine decoction, it is matched with probiotics to play a synergistic effect, the preparation operation is simple, and the prepared Dendrobium oral liquid has stable effect, fewer procedures and high processing efficiency.
  • a compound oral liquid of stachyus and dendrobium comprises the following components and mass ratios: 5-20g of stachyus, 2-10g of dendrobium, 2-10g of jujube, 1-5g of poria cocos, 1-4g of yam, Chenpi 1-5g, Bacillus licheniformis powder 1-5g, Bifidobacterium powder 1-5g.
  • Stachys includes dried rhizomes of stachyus and fresh rhizomes of stachyus.
  • Dendrobium includes Dendrobium Huoshanense and Dendrobium officinale.
  • the formula is mainly Chinese medicinal materials with the same origin as medicine and food, without any additives. On the basis of retaining the characteristics of traditional Chinese medicine decoctions, it is combined with probiotics to play a synergistic effect.
  • a preparation method of stachyus and dendrobium compound oral liquid comprises the following steps:
  • Step 1 Take a certain amount of dendrobium, crush it in a mortar, and set aside.
  • Step 2 Take stachyus, jujube, Poria cocos, yam, and tangerine peel, mix them with the dendrobium in step 1, put them into a container for decoction, add 2-10 times the amount of water for the first time, and add them for the second time after decocting for 2.5 hours. 2-6 times the amount of water, after decocting for 1 hour, add 2-6 times the amount of water for the third time, the temperature of the water is 50-100°C, filter, and combine the decoction.
  • Step 3 the decoction is concentrated to obtain a solution with a relative density of 1.0198-1.0411 and a relative crude drug content of 0.75-1.0 g/ml.
  • Step 4 Pour the concentrated solution of Step 3 into a centrifuge at a centrifuge speed of 3500-4000r/min, perform centrifugation for 10-20min, and take the supernatant for later use.
  • Step 5 Add stachyose to the supernatant of step 4, add stachyose to the oral solution at 1g/100ml-2g/100ml, stir evenly to obtain a mixed solution, and adjust the pH value of the mixed solution to 4.5-5.5.
  • Step six filling.
  • Step 7 sterilization treatment, the temperature of the sterilization treatment is 115-121° C., and the time is 10-20 minutes.
  • Step 9 packaging and labeling, and refrigerating the packaged finished product.
  • a preparation method of stachyus and dendrobium compound oral liquid comprises the following steps:
  • Step 1 Take 2g of dendrobium, crush it in a mortar, and set aside.
  • Step 2 Take 5g of stachyus, 2g of jujube, 1g of poria cocos, 1g of yam, and 1g of tangerine peel, mix them with the dendrobium of step 1, put them into a container for decoction, add 2 times the amount of water for the first time, and decoct for 2.5 hours Add 2 times the amount of water for the second time, and add 2 times the amount of water for the third time after decocting for 1 hour.
  • the temperature of the water is 50°C, filter, and combine the decoction.
  • Step 3 the decoction is concentrated to obtain a solution with a relative density of 1.0198-1.0411 and a relative crude drug content of 0.75-1.0 g/ml.
  • Step 4 Pour the concentrated solution of Step 3 into a centrifuge at a centrifuge speed of 3500r/min for 10 minutes, and take the supernatant for later use.
  • Step 5 Add stachyose to the supernatant of step 4, add stachyose to the oral solution at a rate of 1g/100ml, stir evenly to obtain a mixed solution, and adjust the pH value of the mixed solution to 4.5.
  • Step six filling.
  • Step 7 sterilization treatment, the temperature of the sterilization treatment is 115° C., and the time is 10 minutes.
  • Step 9 packaging and labeling, and refrigerating the packaged finished product.
  • a preparation method of stachyus and dendrobium compound oral liquid comprises the following steps:
  • Step 1 Take 8g of dendrobium, crush it in a mortar, and set aside.
  • Step 2 Take 8g of stachyus, 8g of jujube, 2g of poria cocos, 2g of yam, and 2g of tangerine peel, mix them with the dendrobium of step 1, put them into a container for decoction, add 8 times the amount of water for the first time, and decoct for 2.5 hours Add 4 times the amount of water for the second time, add 4 times the amount of water for the third time after decocting for 1 hour, the temperature of the water is 80°C, filter, and combine the decoction.
  • Step 3 the decoction is concentrated to obtain a solution with a relative density of 1.0198-1.0411 and a relative crude drug content of 0.75-1.0 g/ml.
  • Step 4 pour the concentrated solution of Step 3 into a centrifuge at a centrifuge speed of 3700r/min for 15 minutes, and take the supernatant for later use.
  • Step 5 Add stachyose to the supernatant of step 4, add stachyose to the oral solution at 1.667g/100ml, stir evenly to obtain a mixed solution, and adjust the pH value of the mixed solution to 5.
  • Step six filling.
  • Step 7 sterilization treatment, the temperature of the sterilization treatment is 118° C., and the time is 15 minutes.
  • Step 9 packaging and labeling, and refrigerating the packaged finished product.
  • a preparation method of stachyus and dendrobium compound oral liquid comprises the following steps:
  • Step 1 Take 10g of dendrobium, crush it in a mortar, and set aside.
  • Step 2 Take 20g of stachyus, 10g of jujube, 5g of poria cocos, 4g of yam, and 5g of tangerine peel, mix them with the dendrobium of step 1, put them into a container for decoction, add 10 times the amount of water for the first time, and decoct for 2.5 hours Add 6 times the amount of water for the second time, and add 6 times the amount of water for the third time after decocting for 1 hour.
  • the temperature of the water is 100°C, filter, and combine the decoction.
  • Step 3 the decoction is concentrated to obtain a solution with a relative density of 1.0198-1.0411 and a relative crude drug content of 0.75-1.0 g/ml.
  • Step 4 Pour the concentrated solution of Step 3 into a centrifuge at a centrifugal speed of 4000r/min for 20 minutes, and take the supernatant for later use.
  • Step 5 Add stachyose to the supernatant of step 4, add stachyose to the oral solution at 2 g/100 ml, stir evenly to obtain a mixed solution, and adjust the pH value of the mixed solution to 5.5.
  • Step six filling.
  • Step 7 sterilization treatment, the temperature of the sterilization treatment is 121° C., and the time is 20 minutes.
  • Step 9 packaging and labeling, and refrigerating the packaged finished product.

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Abstract

本发明公开一种水苏与石斛复方口服液及其制备方法，苏斛口服液包括各组分及质量配比：水苏5-20g，石斛2-10g，大枣2-10g，茯苓1-5g，山药1-4g，陈皮1-5g，地衣芽孢杆菌粉1-5g，双歧杆菌粉1-5g，所述水苏包括水苏干燥根茎和水苏新鲜根茎，石斛包括霍山石斛和铁皮石斛。本发明石斛口服液，口服液较药丸，容易被患者吸收，且容易服用，本申请以补气健脾为主，兼能理气消食，润肠通便，用于调理脾胃虚弱，脾虚便秘，水苏下气杀谷除饮食，石斛补五脏虚劳，厚肠胃，茯苓味甘淡，健脾利湿，益气安神以止泻，山药补脾益气，大枣调和脾胃以促运化，配方主要为药食同源中药材，无任何添加剂，在保留中药传统汤剂特色的基础上，搭配益生菌，发挥协同作用。

Description

一种水苏与石斛复方口服液及其制备方法 技术领域
本发明涉及一种口服液，具体是一种水苏与石斛复方口服液及其制备方法。
 背景技术
水苏，是唇形科水苏属多年生草本。植株高20-80厘米，有在节上生须根的根茎。茎单一，直立，四棱形，具槽，在稜及节上被小刚毛，余部无毛。
石斛，又名仙斛兰韵、不死草、还魂草、紫萦仙株、吊兰、林兰、禁生等。茎直立，肉质状肥厚，稍扁的圆柱形。药用植物，性味甘淡微咸，寒，归胃、肾，肺经；其中，霍山石斛又名“米斛”，具有“龙头凤尾”特征。
患者出现脾虚食停的情况，传统的治疗手段，一般采用饮用颗粒药物治疗脾胃，同时服用益生菌，但是多数患者脾胃功能差，不便于消化吸收颗粒药物，孩子不愿意吃药。
发明内容
本发明的目的在于提供一种水苏与石斛复方口服液及其制备方法，针对上述现有技术中提出的药物治疗效果差，不愿服药的问题。
本发明的目的可以通过以下技术方案实现：
一种水苏与石斛复方口服液，所述苏斛口服液包括各组分及质量配比：水苏5-20g，石斛2-10g，大枣2-10g，茯苓1-5g，山药1-4g，陈皮1-5g，地衣芽孢杆菌粉1-5g，双歧杆菌粉1-5g。
进一步的，所述水苏包括水苏干燥根茎和水苏新鲜根茎，石斛包括霍山石斛和铁皮石斛。
一种水苏与石斛复方口服液的制备方法，所述制备方法包括以下步骤：
步骤一、取一定量的石斛，研钵捣碎，备用。
步骤二、取水苏、大枣、茯苓、山药、陈皮，与步骤一的石斛混合，放入容器中煎煮，第一次加入2-10倍量的水，煎煮2.5h后第二次加2-6倍量的水，煎煮1h后第三次加入2-6倍量的水，过滤，合并煎液。
步骤三、煎液浓缩至得到溶液。
步骤四、将步骤三浓缩液倒入离心机，取上清液，备用。
步骤五、向步骤四上清液中加入水苏糖，搅拌均匀得到混合液，调节混合液的PH值至4.5-5.5。
步骤六、灌装。
步骤七、灭菌处理。
步骤八、接种
在无菌的环境下，向步骤七灭菌处理后的溶液内接种地衣芽孢杆菌和双歧杆菌。
步骤九、包装和贴标，将包装好的成品冷藏保存。
进一步的，所述步骤二中所添加水的温度50-100℃。
进一步的，所述步骤三所得溶液的相对密度为1.0198-1.0411，相对生药量为0.75-1.0g/ml。
进一步的，所述步骤四中离心机的离心转速为3500-4000r/min，离心处理时间为10-20min。
进一步的，所述步骤五中向上清液中添加水苏糖的量为1g/100ml-2g/100ml。
进一步的，所述步骤七中灭菌处理的温度为115-121℃，时间为10-20min。
本发明的有益效果：
1、本发明石斛口服液，口服液较药丸，容易被患者吸收，且容易服用，本申请以补气健脾为主，兼能理气消食，润肠通便。用于调理脾胃虚弱，脾虚便秘，双歧杆菌可促进肠道蠕动,起到防止便秘的作用，同时还可以提高免疫，地衣芽孢杆菌是肠道益生菌，改善肠道菌群失调，在促进肠道蠕动的同时，还能补脾益气；
2、本发明石斛口服液的制备方法，配方主要为药食同源中药材，无任何添加剂，在保留中药传统汤剂特色的基础上，搭配益生菌，发挥协同作用，制备操作简单，制备的石斛口服液效果稳定，工序少，加工效率高。
具体实施方式
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其它实施例，都属于本发明保护的范围。
一种水苏与石斛复方口服液，苏斛口服液包括各组分及质量配比：水苏5-20g，石斛2-10g，大枣2-10g，茯苓1-5g，山药1-4g，陈皮1-5g，地衣芽孢杆菌粉1-5g，双歧杆菌粉1-5g。
水苏包括水苏干燥根茎和水苏新鲜根茎。
石斛包括霍山石斛和铁皮石斛。
该配方主要为药食同源中药材，无任何添加剂，在保留中药传统汤剂特色的基础上，搭配益生菌，发挥协同作用，
一种水苏与石斛复方口服液的制备方法，制备方法包括以下步骤：
步骤一、取一定量的石斛，研钵捣碎，备用。
步骤二、取水苏、大枣、茯苓、山药、陈皮，与步骤一的石斛混合，放入容器中煎煮，第一次加入2-10倍量的水，煎煮2.5h后第二次加2-6倍量的水，煎煮1h后第三次加入2-6倍量的水，水的温度50-100℃，过滤，合并煎液。
步骤三、煎液浓缩至得到溶液，相对密度为1.0198-1.0411，相对生药量为0.75-1.0g/ml。
步骤四、将步骤三浓缩液倒入离心机，离心转速为3500-4000r/min，进行离心处理10-20min，取上清液，备用。
步骤五、向步骤四上清液中加入水苏糖，按1g/100ml-2g/100ml口服液加入水苏糖，搅拌均匀得到混合液，调节混合液的PH值至4.5-5.5。
步骤六、灌装。
步骤七、灭菌处理，灭菌处理的温度为115-121℃，时间为10-20min。
步骤八、接种
在无菌的环境下，向步骤七灭菌处理后的溶液内接种地衣芽孢杆菌和双歧杆菌。
步骤九、包装和贴标，将包装好的成品冷藏保存。
实施例1
一种水苏与石斛复方口服液的制备方法，制备方法包括以下步骤：
步骤一、取2g的石斛，研钵捣碎，备用。
步骤二、取5g水苏、2g大枣、1g茯苓、1g山药、1g陈皮，与步骤一的石斛混合，放入容器中煎煮，第一次加入2倍量的水,煎煮2.5h后第二次加2倍量的水，煎煮1h后第三次加入2倍量的水，水的温度50℃，过滤，合并煎液。
步骤三、煎液浓缩至得到溶液，相对密度为1.0198-1.0411，相对生药量为0.75-1.0g/ml。
步骤四、将步骤三浓缩液倒入离心机，离心转速为3500r/min，进行离心处理10min，取上清液，备用。
步骤五、向步骤四上清液中加入水苏糖，按1g/100ml口服液加入水苏糖，搅拌均匀得到混合液，调节混合液的PH值至4.5。
步骤六、灌装。
步骤七、灭菌处理，灭菌处理的温度为115℃，时间为10min。
步骤八、接种
在无菌的环境下，向步骤七灭菌处理后的溶液内接种地衣芽孢杆菌粉1g和双歧杆菌粉1g。
步骤九、包装和贴标，将包装好的成品冷藏保存。
实施例2
一种水苏与石斛复方口服液的制备方法，制备方法包括以下步骤：
步骤一、取8g石斛，研钵捣碎，备用。
步骤二、取8g水苏、8g大枣、2g茯苓、2g山药、2g陈皮，与步骤一的石斛混合，放入容器中煎煮，第一次加入8倍量的水,煎煮2.5h后第二次加4倍量的水，煎煮1h后第三次加入4倍量的水，水的温度80℃，过滤，合并煎液。
步骤三、煎液浓缩至得到溶液，相对密度为1.0198-1.0411，相对生药量为0.75-1.0g/ml。
步骤四、将步骤三浓缩液倒入离心机，离心转速为3700r/min，进行离心处理15min，取上清液，备用。
步骤五、向步骤四上清液中加入水苏糖，按1.667g/100ml口服液加入水苏糖，搅拌均匀得到混合液，调节混合液的PH值至5。
步骤六、灌装。
步骤七、灭菌处理，灭菌处理的温度为118℃，时间为15min。
步骤八、接种
在无菌的环境下，向步骤七灭菌处理后的溶液内接种地衣芽孢杆菌粉3g和双歧杆菌粉3g。
步骤九、包装和贴标，将包装好的成品冷藏保存。
实施例3
一种水苏与石斛复方口服液的制备方法，制备方法包括以下步骤：
步骤一、取10g石斛，研钵捣碎，备用。
步骤二、取20g水苏、10g大枣、5g茯苓、4g山药、5g陈皮，与步骤一的石斛混合，放入容器中煎煮，第一次加入10倍量的水,煎煮2.5h后第二次加6倍量的水，煎煮1h后第三次加入6倍量的水，水的温度100℃，过滤，合并煎液。
步骤三、煎液浓缩至得到溶液，相对密度为1.0198-1.0411，相对生药量为0.75-1.0g/ml。
步骤四、将步骤三浓缩液倒入离心机，离心转速为4000r/min，进行离心处理20min，取上清液，备用。
步骤五、向步骤四上清液中加入水苏糖，按2g/100ml口服液加入水苏糖，搅拌均匀得到混合液，调节混合液的PH值至5.5。
步骤六、灌装。
步骤七、灭菌处理，灭菌处理的温度为121℃，时间为20min。
步骤八、接种
在无菌的环境下，向步骤七灭菌处理后的溶液内接种地衣芽孢杆菌粉5g和双歧杆菌粉5g。
步骤九、包装和贴标，将包装好的成品冷藏保存。
在本说明书的描述中，参考术语“一个实施例”、“示例”、“具体示例”等的描述意指结合该实施例或示例描述的具体特征、结构、材料和特点包含于本发明的至少一个实施例或示例中。在本说明书中，对上述术语的示意性表述不一定指的是相同的实施例或示例。而且，描述的具体特征、结构、材料和特点可以在任何的一个或多个实施例或示例中以合适的方式结合。
以上显示和描述了本发明的基本原理、主要特征和本发明的优点。本行业的技术人员应该了解，本发明不受上述实施例的限制，上述实施例和说明书中描述的只是说明本发明的原理，在不脱离本发明精神和范围的前提下，本发明还会有各种变化和改进，这些变化和改进都落入要求保护的本发明范围内。

Claims (8)

  1. 一种水苏与石斛复方口服液，其特征在于，所述苏斛口服液包括各组分及质量配比：水苏5-20g，石斛2-10g，大枣2-10g，茯苓1-5g，山药1-4g，陈皮1-5g，地衣芽孢杆菌粉1-5g，双歧杆菌粉1-5g。
  2. 根据权利要求1所述的一种水苏与石斛复方口服液，其特征在于，所述水苏包括水苏干燥根茎和水苏新鲜根茎，石斛包括霍山石斛和铁皮石斛。
  3. 根据权利要求1-2任意一项所述的一种水苏与石斛复方口服液的制备方法，其特征在于，所述制备方法包括以下步骤：
    步骤一、取一定量的石斛，研钵捣碎，备用；
    步骤二、取水苏、大枣、茯苓、山药、陈皮，与步骤一的石斛混合，放入容器中煎煮，第一次加入2-10倍量的水，煎煮2.5h后第二次加2-6倍量的水，煎煮1h后第三次加入2-6倍量的水，过滤，合并煎液；
    步骤三、煎液浓缩至得到溶液；
    步骤四、将步骤三浓缩液倒入离心机，取上清液，备用；
    步骤五、向步骤四上清液中加入水苏糖，搅拌均匀得到混合液，调节混合液的PH值至4.5-5.5；
    步骤六、灌装；
    步骤七、灭菌处理；
    步骤八、接种
    在无菌的环境下，向步骤七灭菌处理后的溶液内接种地衣芽孢杆菌和双歧杆菌；
    步骤九、包装和贴标，将包装好的成品冷藏保存。
  4. 根据权利要求3所述的一种水苏与石斛复方口服液的制备方法，其特征在于，所述步骤二中所添加水的温度50-100℃。
  5. 根据权利要求3所述的一种水苏与石斛复方口服液的制备方法，其特征在于，所述步骤三所得溶液的相对密度为1.0198-1.0411，相对生药量为0.75-1.0g/ml。
  6. 根据权利要求3任意一项所述的一种水苏与石斛复方口服液的制备方法，其特征在于，所述步骤四中离心机的离心转速为3500-4000r/min，离心处理时间为10-20min。
  7. 根据权利要求3所述的一种水苏与石斛复方口服液的制备方法，其特征在于，所述步骤五中向上清液中添加水苏糖的量为1g/100ml-2g/100ml。
  8. 根据权利要求3所述的一种水苏与石斛复方口服液的制备方法，其特征在于，所述步骤七中灭菌处理的温度为115-121℃，时间为10-20min。
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