WO2023095355A1 - 超音波治療装置 - Google Patents
超音波治療装置 Download PDFInfo
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- WO2023095355A1 WO2023095355A1 PCT/JP2022/010587 JP2022010587W WO2023095355A1 WO 2023095355 A1 WO2023095355 A1 WO 2023095355A1 JP 2022010587 W JP2022010587 W JP 2022010587W WO 2023095355 A1 WO2023095355 A1 WO 2023095355A1
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- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 45
- 239000000523 sample Substances 0.000 claims abstract description 38
- 230000005540 biological transmission Effects 0.000 claims abstract description 20
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 9
- 238000002604 ultrasonography Methods 0.000 claims description 57
- 238000000034 method Methods 0.000 abstract description 17
- 238000012790 confirmation Methods 0.000 abstract description 4
- 238000003384 imaging method Methods 0.000 description 48
- 238000011287 therapeutic dose Methods 0.000 description 14
- 238000010586 diagram Methods 0.000 description 5
- 238000006073 displacement reaction Methods 0.000 description 3
- 230000002194 synthesizing effect Effects 0.000 description 3
- 210000003484 anatomy Anatomy 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 239000002872 contrast media Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 230000036544 posture Effects 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/13—Tomography
- A61B8/14—Echo-tomography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0052—Ultrasound therapy using the same transducer for therapy and imaging
Definitions
- the present invention relates to an ultrasonic therapeutic device, and more particularly to a device comprising a therapeutic ultrasonic transducer and an ultrasonic probe for image generation.
- a treatment device that uses high-intensity focused ultrasound therapy is widely used.
- This treatment apparatus is called a HIFU irradiation apparatus or HIFU irradiation system (High Intensity Focused Ultrasound), and irradiates ultrasonic waves to a treatment site to necrotize tissue.
- a HIFU irradiation device is equipped with a plurality of ultrasonic transducers arranged on a bowl-shaped surface.
- the plurality of ultrasonic transducers are arranged so that the ultrasonic waves emitted from each are irradiated to one point to form a focal point.
- ultrasonic waves are emitted with the focus adjusted to the treatment site.
- An ultrasonic diagnostic apparatus that shows a focal point on an ultrasonic image is used to confirm the irradiation position.
- Patent Document 1 describes an ultrasonic therapeutic apparatus that observes the position of a focal point using an ultrasonic diagnostic apparatus that displays a B-mode image (tomographic image).
- a B-mode image tomographic image
- ultrasonic waves of a weak level that do not affect tissues are emitted from a therapeutic ultrasonic transducer, and a tomographic image is displayed by transmission and reception of ultrasonic waves by an ultrasonic imaging probe. Since the acoustic properties of the tissue of the subject change according to the temperature change of the tissue, the tomographic image shows the position of the focal point by the strength of the luminance.
- Patent Document 2 describes, as a technique related to the present invention, an echo component generated by scattering by a microbubble-based contrast agent, which is visualized by distinguishing it from a component generated by nonlinear propagation of a transmission pulse.
- confirmation of irradiation of the therapeutic ultrasonic wave to the affected area is performed by observing the position of bubbles generated by the therapeutic ultrasonic wave and observing the patient's living tissue.
- Observation of the position of a bubble is performed, for example, by harmonic imaging in which ultrasonic waves are transmitted from an ultrasonic probe toward an affected area and harmonics generated around the bubble are received by the ultrasonic probe.
- Observation of a patient's biological tissue is performed by acquiring a B-mode image through transmission and reception of ultrasonic waves by an ultrasonic probe.
- this confirmation method it is necessary to separately observe the position of the bubble and the living tissue, and the procedure is complicated and not easy.
- the purpose of the present invention is to facilitate confirmation that therapeutic ultrasound has been applied to an affected area in treatment using an ultrasonic therapy apparatus.
- the present invention comprises a therapeutic ultrasonic transducer, an ultrasonic probe, and a control section for controlling the ultrasonic transducer and the ultrasonic probe, wherein the control section controls the ultrasonic transducer for treatment.
- a therapeutic ultrasonic wave transmission process for transmitting therapeutic ultrasonic waves, and a plurality of ultrasonic waves are transmitted to the ultrasonic probe at different timings, reflected by living tissue, and transmitted to the plurality of ultrasonic waves received by the ultrasonic probe an irradiation area image generation process of synthesizing a plurality of received signals based on the received signals and generating irradiation area data based on the harmonic components of each of the received signals; and B-mode image generation processing for generating mode image data.
- control unit causes the display device to display a first image based on the irradiation area data and a second image based on the B-mode image data.
- control unit causes the display device to display the first image and the second image in an overlapping manner.
- control unit displays a graphic indicating a treatment reference region or a treatment reference point corresponding to the position of the ultrasonic transducer so as to be superimposed on the second image.
- control unit detects the movement of the living tissue based on the B-mode image data sequentially generated over time, and calculates the treatment amount at each position in the patient coordinate system fixed to the living tissue. , based on each of the irradiation area data corresponding to each of the B-mode image data.
- a driving device for driving the ultrasonic transducer is provided, and the control unit detects the movement of the living tissue based on the B-mode image data sequentially generated over time, and detects the movement of the living tissue. to move the ultrasonic transducer according to the movement of the living tissue.
- the present invention it is possible to easily confirm that the therapeutic ultrasound has been irradiated to the affected area.
- FIG. 2 is a diagram conceptually showing temporal waveforms of therapeutic ultrasound and imaging ultrasound.
- FIG. 4 is a diagram schematically showing a B-mode irradiation area image together with a HIFU transducer unit;
- FIG. 4 is a diagram showing a B-mode irradiation area image that changes over time and a treatment dose distribution;
- FIG. 4 is a diagram schematically showing a B-mode irradiation area image, contours of living tissue, and a HIFU transducer unit under tracking irradiation processing;
- FIG. 1 shows the configuration of a HIFU irradiation apparatus 100 (ultrasonic therapeutic apparatus) according to an embodiment of the present invention.
- the HIFU irradiation apparatus 100 includes a HIFU transducer unit 10, a HIFU drive circuit 14, an ultrasound probe 16, a transmission/reception circuit 18, an imaging calculation section 20, a controller 22, a display device 24 and a drive device 26.
- the controller 22 may be a personal computer, a tablet computer, or the like.
- the controller 22 is connected with operating equipment (not shown) for the user to operate the HIFU irradiation apparatus 100 .
- the operating device may include a mouse, a touch panel integrated with the display device 24, a switch, a keyboard, and the like.
- the HIFU transducer unit 10 includes a bowl-shaped transducer housing 12 with a downward opening, and a plurality of ultrasonic transducers 1 fixed to the transducer housing 12 .
- the shape of the transducer housing 12 may be similar to the side surface of a cone.
- a cone refers to a three-dimensional shape formed by a collection of straight lines extending from one point in space to the bottom surface.
- Each ultrasonic transducer 1 is arranged in a transducer housing so that when each ultrasonic transducer 1 emits an ultrasonic wave, the intensity of the ultrasonic wave is increased at the treatment reference point P below the transducer housing 12. 12 is fixed.
- the HIFU drive circuit 14 causes each ultrasonic transducer 1 included in the HIFU transducer unit 10 to generate ultrasonic waves under the control of the controller 22 .
- the HIFU drive circuit 14 also adjusts the intensity of the ultrasonic waves generated by each ultrasonic transducer 1 under the control of the controller 22 .
- the ultrasonic probe 16 is fixed to the transducer housing 12 so that ultrasonic waves are transmitted and received at a position below the transducer housing 12 and above the treatment reference point P.
- the ultrasonic probe 16 vertically penetrates through the vertex of the transducer housing 12, and the transmitting/receiving section 2 for transmitting/receiving ultrasonic waves faces downward.
- a general ultrasonic diagnostic apparatus may be used for the transmission/reception circuit 18 and the imaging calculation unit 20 .
- the imaging calculation section 20 may be configured by a processor that executes a program to control the transmission/reception circuit 18 .
- the transmitting/receiving circuit 18 performs the following processing under the control of the imaging calculation section 20 . That is, the transmitting/receiving circuit 18 causes the ultrasonic probe 16 to transmit ultrasonic waves and scan beams (ultrasonic beams) of the transmitted ultrasonic waves.
- the ultrasonic beam is scanned on an observation plane including the central axis 3 extending vertically from the vertex of the transducer housing 12 .
- the transmission/reception circuit 18 causes the ultrasonic probe 16 to receive the reflected ultrasonic waves arriving from the directions in which the ultrasonic beams are directed, and the received signals based on the reflected ultrasonic waves received from each direction in which the ultrasonic beams are directed, Acquired from the ultrasonic probe 16 .
- the transmission/reception circuit 18 outputs each reception signal to the imaging calculation section 20 .
- the imaging calculation unit 20 generates ultrasound data based on each reception signal output from the transmission/reception circuit 18 .
- the ultrasound data is irradiation area data indicating an area where harmonic components are generated in the patient's body tissue, or B-mode image data indicating a B-mode image (tomographic image) acquired from the patient's body tissue. you can
- the driving device 26 moves the HIFU transducer unit 10 and the ultrasonic probe 16 and adjusts their positions under the control of the controller 22 . Further, the driving device 26 may rotate the ultrasonic probe 16 around the central axis 3 and rotate the observation surface of the ultrasonic probe 16 around the central axis 3 under the control of the controller 22 .
- the following positioning processing is performed before therapeutic ultrasound is emitted from the HIFU transducer unit 10 to the patient.
- the HIFU drive circuit 14 causes each ultrasonic transducer 1 to transmit ultrasonic waves with a lower intensity than that used during treatment.
- the driving device 26 sets the rotational angular position of the ultrasonic probe 16 so that the ultrasonic probe 16 scans an observation plane at a predetermined rotational angular position with an ultrasonic beam.
- the imaging calculation unit 20 causes the ultrasound probe 16 to scan an ultrasound beam on the observation plane, acquires B-mode image data as ultrasound data, and outputs it to the controller 22 .
- the controller 22 causes the display device 24 to display the B-mode image.
- the user as a practitioner refers to the B-mode image displayed on the display device 24 to confirm the difference between the position (focus) where the ultrasonic waves transmitted from the HIFU transducer unit 10 are intensified and the position of the affected area. .
- the user changes the positions or postures of the ultrasonic probe 16 and the HIFU transducer unit 10 when the difference between the focus position and the affected part position is not within the allowable range. After confirming that the position of the focus and the position of the affected area match or that the difference between the position of the focus and the position of the affected area is within an allowable range, the user sends the controller 22 for treatment. operation.
- the controller 22 controls the HIFU drive circuit 14 according to user's operation.
- the HIFU driving circuit 14 causes each ultrasonic transducer 1 to transmit therapeutic ultrasonic waves having an intensity necessary for treatment according to control by the controller 22 . This causes the living tissue to be cauterized and treated at the focal point.
- the HIFU irradiation apparatus 100 performs an irradiation area display process for displaying an image showing an irradiation area irradiated with therapeutic ultrasound on the display device 24 while irradiating the patient with therapeutic ultrasound. do.
- the process of superimposing and displaying two images involves synthesizing image data so that the other image can be seen through one image, generating new image data, and generating an image based on the new image data. It may be processing to display.
- FIG. 2 conceptually shows time waveforms of therapeutic ultrasound waves 38 transmitted from the HIFU transducer unit 10 and imaging ultrasound waves 46 transmitted from the ultrasound probe 16 when the irradiation area display processing is executed. shown in
- the therapeutic ultrasound 38 is composed of strong and weak ultrasound pulses 44 including strong level ultrasound 40 and weak level ultrasound 42 following the strong level ultrasound 40 .
- a strong and weak ultrasonic pulse 44 is repeatedly transmitted from the HIFU transducer unit 10 over time.
- An irradiation pause period 48 is provided between the strong and weak ultrasonic pulses 44 adjacent on the time axis, and the transmission of the therapeutic ultrasonic waves 38 is stopped during the irradiation pause period 48 .
- the living tissue When a strong and weak ultrasonic pulse 44 is transmitted from the HIFU transducer unit 10, the living tissue is cauterized at the focal point. While the strong-level ultrasonic waves 40 are applied to the living tissue, bubbles are generated from the living tissue, and the bubble-generated state is maintained by the irradiation of the weak-level ultrasonic waves 42 .
- the imaging ultrasonic waves 46 for generating ultrasonic data are transmitted from the ultrasonic probe 16 three times.
- the second imaging ultrasonic wave 46-2 transmitted for the second time is delayed by 120° in phase with respect to the first imaging ultrasonic wave 46-1 transmitted for the first time.
- the third imaging ultrasonic wave 46-3 transmitted for the third time is delayed by 120° in phase with respect to the second imaging ultrasonic wave 46-2.
- Each imaging ultrasound wave 46 is reflected within living tissue. Harmonics are generated as each imaging ultrasound wave 46 reflects around the bubble generated by the strong and weak ultrasound pulse 44 . Therefore, the reflected ultrasonic waves reflected from the living tissue contain harmonics caused by air bubbles in addition to the fundamental wave. In general, the greater the amount of generated bubbles, the greater the intensity of generated harmonics.
- the ultrasonic probe 16 receives the first to third reflected ultrasonic waves from the first imaging ultrasonic wave 46-1 to the third imaging ultrasonic wave 46-3, and respectively receives the first received signal to the third received signal is output to the transmission/reception circuit 18 .
- the transmitting/receiving circuit 18 amplifies the first to third received signals and outputs them to the imaging calculation unit 20 .
- the imaging calculation unit 20 sums up the first to third received signals and generates a harmonic signal by summing up the harmonic components contained in each of the first to third received signals. Due to the phase relationship between the first imaging ultrasonic wave 46-1 to the third imaging ultrasonic wave 46-3, the fundamental wave component is suppressed in the signal obtained by summing the first received signal to the third received signal.
- the imaging calculation unit 20 generates harmonic signals for the first to third reflected ultrasonic waves arriving from each direction in which the ultrasonic beam is directed, and generates harmonic signals for each direction. Generate irradiation area data based on.
- the irradiation area data is image data representing an irradiation area image showing an area where bubbles are generated in the area scanned with the ultrasonic beam.
- the imaging calculation unit 20 generates a B-mode image based on one of the first to third reflected ultrasound waves. For example, the imaging calculation unit 20 generates pixel data of a B-mode image in each direction based on the second reflected ultrasonic waves arriving from each direction in which the ultrasonic beam is directed, and obtains pixel data in each direction. B-mode image data is generated based on the data. Note that the reflected ultrasound that is the basis of the B-mode image data may be the first reflected ultrasound or the third reflected ultrasound.
- the imaging calculation unit 20 outputs irradiation area data and B-mode image data to the controller 22 .
- the controller 22 causes the display device 24 to display an image (B-mode irradiation area image) in which the irradiation area image is superimposed on the B-mode image based on the irradiation area data and the B-mode image data.
- the imaging calculation unit 20 outputs irradiation area data and B-mode image data to the controller 22 at frame time intervals (reciprocal of the frame rate).
- the controller 22 causes the display device 24 to sequentially display the B-mode irradiation area images as time elapses.
- the controller 22 may cause the display device 24 to display a figure indicating the treatment reference point P superimposed on the B-mode irradiation area image. Further, the controller 22 may cause the display device 24 to display a graphic indicating the area around the treatment reference point P and the treatment reference point P (treatment reference area) superimposed on the B-mode irradiation area image.
- the controller 22 may display the image based on the irradiation area data and the B-mode image separately without overlapping the images.
- the controller 22 may cause the display device 24 to display the image based on the irradiation area data and the B-mode image side by side so that they can be compared.
- FIG. 3 schematically shows the B-mode irradiation area image 52 together with the HIFU transducer unit 10.
- a B-mode image 54 is shown in a scanning area scanned with an ultrasonic beam, and an irradiation area 60 is an air bubble image formed by harmonics of reflected waves.
- Imaging ultrasound may be transmitted two or more times.
- the phase difference between adjacent imaging ultrasonic waves on the time axis is 360°/M.
- each imaging ultrasound is assigned a phase of ⁇ +i ⁇ 360°/M (where ⁇ is an arbitrary phase and i is an integer from 0 to M ⁇ 1).
- the phase of the sound waves may be set.
- the imaging calculation unit 20 sums up the first to Mth received signals and generates a harmonic signal by summing up the harmonic components contained in each of the first to Mth received signals. Also, the imaging calculation unit 20 generates a B-mode image based on one of the first to M-th reflected ultrasound waves.
- the HIFU irradiation apparatus 100 includes the HIFU transducer unit 10 including the therapeutic ultrasound transducer 1, the ultrasound probe 16, and the control unit 30 that controls the ultrasound transducer 1 and the ultrasound probe 16. It has The control section 30 is composed of the HIFU drive circuit 14 , the transmission/reception circuit 18 , the imaging calculation section 20 and the controller 22 .
- the control unit 30 executes therapeutic ultrasound transmission processing, irradiation area image generation processing, and B-mode image generation processing.
- the therapeutic ultrasonic wave transmission process is a process for causing the ultrasonic transducer 1 to transmit therapeutic ultrasonic waves.
- a plurality of ultrasonic waves are transmitted to the ultrasonic probe 16 at different timings, reflected by the living tissue, and the first to Mth reflected ultrasonic waves received by the ultrasonic probe 16 (a plurality of This is a process of summing up (synthesizing) the first received signal to the Mth received signal (a plurality of received signals) based on the ultrasonic wave) and generating irradiation area data based on the harmonic components of each received signal.
- B-mode image generation processing is processing for generating B-mode image data of living tissue using one of a plurality of received signals.
- the control unit 30 executes display processing for causing the display device 24 to display a first image based on the irradiation area data and a second image based on the B-mode image data.
- the control unit 30 may cause the display device 24 to display the first image and the second image in an overlapping manner. Further, the control unit 30 may cause the display device 24 to display a graphic indicating a reference treatment area or a graphic indicating the reference point P for treatment corresponding to the position of the ultrasonic transducer 1 so as to be superimposed on the second image.
- the biological tissue is irradiated with therapeutic ultrasound waves, and the region irradiated with the therapeutic ultrasound waves is displayed on the B-mode image.
- B-mode image data is generated using reflected ultrasound from any of the multiple imaging ultrasounds to generate the illuminated area data. This makes it easier for the user to confirm that the therapeutic ultrasound has been applied to the affected area.
- the controller 22 obtains patient coordinate system irradiation data in which each coordinate value in the patient coordinate system fixed to the patient (each position in the patient coordinate system fixed to the living tissue) is associated with the irradiation dose. good too.
- the dose may be defined as the pixel value of the irradiation area data.
- the patient coordinate system irradiation data represents the distribution of the dose in the patient coordinate system.
- the controller 22 performs tracking processing on the B-mode image data sequentially output from the imaging calculation unit 20 at frame time intervals, and detects the movement of the living tissue on the B-mode image that appears in the B-mode image. This detection may be performed as follows.
- the controller 22 generates data specifying the contour of the living tissue based on the B-mode image data.
- the controller 22 obtains the dose based on the pixel values of the irradiation area data obtained together with the B-mode image data for each coordinate value in the patient coordinate system fixed with respect to the contour, thereby performing patient coordinate system irradiation.
- Generate data By generating patient coordinate system irradiation data for each B-mode image data sequentially output from the imaging calculation unit 20 at frame time intervals, patient coordinate system irradiation data that follows the movement of living tissue on the B-mode image. is generated.
- the upper part of FIG. 4 shows B-mode irradiation area images 52 that are sequentially generated over time, together with an xy coordinate system as a patient coordinate system 56 .
- the B-mode irradiation area image 52 changes over time from the image shown on the left to the image shown on the right.
- the patient moves to the right, and the body tissue contour 50 and the patient coordinate system 56 move to the right as time elapses.
- the irradiation area 60 does not move with respect to the B-mode irradiation area image 52 , but moves leftward with respect to the patient coordinate system 56 .
- the patient coordinate system irradiation data is obtained by associating the irradiation amount with each coordinate value of the patient coordinate system 56 that moves rightward with the patient.
- the controller 22 obtains patient coordinate system irradiation data for each B-mode image data sequentially output from the imaging calculation unit 20 at frame time intervals, and calculates the irradiation dose for each coordinate value in the patient coordinate system for a predetermined number of frames. A therapeutic dose summed over a period of time may be determined. The controller 22 may obtain therapeutic dose distribution data in which each coordinate value in the patient coordinate system is associated with a therapeutic dose.
- the lower part of FIG. 4 shows the therapeutic dose distribution 58 indicated by the therapeutic dose distribution data generated with respect to the patient coordinate system 56 .
- the therapeutic amount obtained by summing up the pixel values of the irradiation region 60 at each time is shown by a figure superimposed on the irradiation region 60 at each time.
- Treatment dose distribution 58 shows that patient movement has caused the treatment dose to be distributed to the left of contour 50 .
- the controller 22 may cause the display device 24 to display a therapeutic dose distribution image based on the therapeutic dose distribution data.
- the therapeutic dose distribution image is an image representing the distribution of the therapeutic dose in the patient coordinate system.
- the controller 22 may cause the display device 24 to display a therapeutic dose distribution image in which the luminance of pixels representing living tissue increases as the therapeutic dose increases.
- the treatment dose distribution image may be colored so that the treatment dose is colored according to the treatment dose.
- the controller 22 detects the movement of the living tissue based on the B-mode image data that is sequentially generated over time, and calculates the treatment amount at each position in the patient coordinate system fixed to the living tissue. It is obtained based on each irradiation area data corresponding to the mode image data.
- the therapeutic dose distribution data is data in which a therapeutic dose is associated with each position in a patient coordinate system fixed to the patient. Thus, a therapeutic dose associated with the patient's anatomy is indicated even if the patient moves during treatment.
- a follow-up irradiation process according to an application embodiment of the present invention will be described.
- the controller 22 detects the movement of the living tissue based on the B-mode image data that is sequentially generated over time, controls the driving device 26 according to the movement of the living tissue, The ultrasonic transducer 1 of the HIFU transducer unit 10 is moved according to the movement of living tissue.
- the controller 22 performs tracking processing on the B-mode image data sequentially output from the imaging calculation unit 20 at frame time intervals. That is, the amount of displacement of the living tissue appearing in the B-mode image on the B-mode image is obtained at frame time intervals. For example, the controller 22 generates data specifying the contour of the living tissue based on the B-mode image data, and based on each B-mode image data generated at the frame time interval, the contour displacement at the frame time interval. ask for quantity.
- the controller 22 controls the driving device 26 so that the treatment reference point P moves by the displacement amount of the contour at time intervals that are K times the frame time interval.
- K is an integer of 1 or more.
- the driving device 26 moves the HIFU transducer unit 10 and the ultrasonic probe 16 under the control of the controller 22 .
- FIG. 5 schematically shows a B-mode irradiation area image 52, a body tissue contour 50, and the HIFU transducer unit 10 under tracking irradiation processing.
- the B-mode irradiation area image 52 shows the irradiation area 60 as an image of bubbles (an image obtained by harmonic imaging).
- An anatomy contour 50 is also shown. Inside the contour 50 is an illuminated area 60, as shown in the left-hand view of FIG.
- the center view of FIG. 5 shows that the patient's body has moved to the right, causing contour 50 to move to the right from its original position shown in dashed lines.
- FIG. 5 shows the HIFU transducer unit 10 moving to the right following the movement of the contour 50 .
- the irradiation area 60 is again located near the center of the tissue contour 50, indicating that the therapeutic ultrasound is applied to the appropriate location.
- the outline 50 is shown on the B-mode irradiation area image 52 in FIG. 5 , the outline 50 does not necessarily have to be displayed on the display device 24 .
- the focus of the therapeutic ultrasound follows the movement of the contour 50, that is, the movement of the specific living tissue.
- the focus follows the movement of the affected area according to the movement of the patient's body, and the affected area is irradiated with therapeutic ultrasound.
- HIFU transducer unit 10 HIFU transducer unit, 12 ultrasound transducer, 14 HIFU drive circuit, 16 ultrasound probe, 18 transmission/reception circuit, 20 imaging calculation unit, 22 controller, 24 display device, 26 drive device, 40 strong level ultrasound, 42 weak Level ultrasound, 44 Strong and weak ultrasound pulse, 46-1 First imaging ultrasound, 46-2 Second imaging ultrasound, 46-3 Third imaging ultrasound, 48 Irradiation rest period, 50 Contour, 52 B mode irradiation area Image, 54 B-mode image, 56 patient coordinate system, 58 treatment dose distribution, 60 irradiation area, 100 HIFU irradiation device.
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Abstract
Description
Claims (6)
- 治療用の超音波振動子と、
超音波プローブと、
前記超音波振動子および前記超音波プローブを制御する制御部と、を備え、
前記制御部は、
前記超音波振動子に治療用超音波を送信させる治療用超音波送信処理と、
複数の超音波を異なるタイミングで前記超音波プローブに送信させ、生体組織で反射し、前記超音波プローブで受信された複数の前記超音波に基づく複数の受信信号を合成し、各前記受信信号の高調波成分に基づく照射領域データを生成する照射領域画像生成処理と、
複数の前記受信信号のうちいずれかを用いて、前記生体組織のBモード画像データを生成するBモード画像生成処理と、
を実行することを特徴とする超音波治療装置。 - 請求項1に記載の超音波治療装置において、
前記制御部は、
前記照射領域データに基づく第1画像と、前記Bモード画像データに基づく第2画像とを表示装置に表示させることを特徴とする超音波治療装置。 - 請求項2に記載の超音波治療装置において、
前記制御部は、
前記第1画像と前記第2画像とを重ねて前記表示装置に表示させることを特徴とする超音波治療装置。 - 請求項2または請求項3に記載の超音波治療装置において、
前記制御部は、
前記超音波振動子の位置に応じた治療基準領域または治療基準点を示す図形を、前記第2画像に重ねて表示することを特徴とする超音波治療装置。 - 請求項1から請求項4のいずれか1項に記載の超音波治療装置において、
前記制御部は、時間経過と共に順次生成される前記Bモード画像データに基づいて前記生体組織の動きを検出し、
前記生体組織に固定された患者座標系における各位置での治療量を、各前記Bモード画像データに対応する各前記照射領域データに基づいて求めることを特徴とする超音波治療装置。 - 請求項1から請求項5のいずれか1項に記載の超音波治療装置において、
前記超音波振動子を駆動する駆動装置を備え、
前記制御部は、時間経過と共に順次生成される前記Bモード画像データに基づいて前記生体組織の動きを検出し、
前記生体組織の動きに応じて前記駆動装置を制御し、前記超音波振動子を前記生体組織の動きに応じて移動させることを特徴とする超音波治療装置。
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CN202280075862.3A CN118251258A (zh) | 2021-11-29 | 2022-03-10 | 超声波治疗装置 |
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JP2021192735A JP7137682B1 (ja) | 2021-11-29 | 2021-11-29 | 超音波治療装置 |
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JP (1) | JP7137682B1 (ja) |
KR (1) | KR20240112916A (ja) |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0871069A (ja) | 1994-09-02 | 1996-03-19 | Toshiba Corp | 超音波治療装置 |
JP2004344672A (ja) * | 2004-07-09 | 2004-12-09 | Toshiba Corp | 超音波治療装置 |
WO2005058168A2 (ja) * | 2003-12-16 | 2005-06-30 | Hitachi Medical Corp | 超音波体動検出装置、及びこれを用いた画像提示装置及び超音波治療装置 |
WO2005087109A1 (ja) | 2004-03-12 | 2005-09-22 | Hitachi Medical Corporation | 超音波撮像装置 |
JP2013055984A (ja) * | 2011-09-07 | 2013-03-28 | Hitachi Aloka Medical Ltd | 超音波診断装置および超音波診断用プログラム |
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JP5929368B2 (ja) | 2012-03-16 | 2016-06-01 | コニカミノルタ株式会社 | 超音波画像診断装置 |
FR3081334B1 (fr) | 2018-05-25 | 2020-05-01 | Cardiawave Sa | Appareil de traitement par ultrasons comportant des moyens d'imagerie des bulles de cavitation |
CN109431536B (zh) | 2018-09-17 | 2019-08-23 | 西安交通大学 | 一种聚焦超声空化的实时高分辨时空分布成像方法与系统 |
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- 2022-03-10 KR KR1020247021467A patent/KR20240112916A/ko unknown
- 2022-03-10 CN CN202280075862.3A patent/CN118251258A/zh active Pending
- 2022-03-10 WO PCT/JP2022/010587 patent/WO2023095355A1/ja active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0871069A (ja) | 1994-09-02 | 1996-03-19 | Toshiba Corp | 超音波治療装置 |
WO2005058168A2 (ja) * | 2003-12-16 | 2005-06-30 | Hitachi Medical Corp | 超音波体動検出装置、及びこれを用いた画像提示装置及び超音波治療装置 |
WO2005087109A1 (ja) | 2004-03-12 | 2005-09-22 | Hitachi Medical Corporation | 超音波撮像装置 |
JP2004344672A (ja) * | 2004-07-09 | 2004-12-09 | Toshiba Corp | 超音波治療装置 |
JP2013055984A (ja) * | 2011-09-07 | 2013-03-28 | Hitachi Aloka Medical Ltd | 超音波診断装置および超音波診断用プログラム |
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JP2023079320A (ja) | 2023-06-08 |
JP7137682B1 (ja) | 2022-09-14 |
KR20240112916A (ko) | 2024-07-19 |
CN118251258A (zh) | 2024-06-25 |
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