WO2023009448A1 - Circadian rhythm restoring blue blockers - Google Patents
Circadian rhythm restoring blue blockers Download PDFInfo
- Publication number
- WO2023009448A1 WO2023009448A1 PCT/US2022/038207 US2022038207W WO2023009448A1 WO 2023009448 A1 WO2023009448 A1 WO 2023009448A1 US 2022038207 W US2022038207 W US 2022038207W WO 2023009448 A1 WO2023009448 A1 WO 2023009448A1
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- WIPO (PCT)
- Prior art keywords
- refraction
- layer
- index
- wearable device
- spectral filter
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Classifications
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- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/10—Filters, e.g. for facilitating adaptation of the eyes to the dark; Sunglasses
- G02C7/104—Filters, e.g. for facilitating adaptation of the eyes to the dark; Sunglasses having spectral characteristics for purposes other than sun-protection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/02—Goggles
- A61F9/022—Use of special optical filters, e.g. multiple layers, filters for protection against laser light or light from nuclear explosions, screens with different filter properties on different parts of the screen; Rotating slit-discs
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B5/00—Optical elements other than lenses
- G02B5/20—Filters
- G02B5/28—Interference filters
- G02B5/285—Interference filters comprising deposited thin solid films
Definitions
- the disclosed embodiments relate to eyewear and spectral filters.
- One example wearable device for viewing a real or virtual environment includes one or more windows positioned to allow light from the real or virtual environment to propagate toward a position where a wearer's eyes would be located, and a spectral filter that comprises a coating positioned on one or more sections of the one or more windows.
- the spectral filter includes a multi-layer stack of dielectric material with alternate high and low indices of refraction such that a layer having a high index of refraction is positioned above or below a layer having a low index of reflection, and a layer having a high index of refraction is positioned above or below a layer having a low index of reflection.
- the number of the layers and a thickness of each layer are selected to provide designed transmission and blocking characteristics to block circadian-rhythm-disruptive spectra from reaching the wearer's eyes while providing viewability of the real or virtual environment by allowing light outside of the circadian-rhythm-disruptive spectra to reach the wearer's eyes.
- the designed transmission and blocking characteristics include three contiguous blocking regions at 365-400 nm, 455-495 nm, and 530-560 nm bands of wavelengths, and three contiguous transmission regions at 405-450 nm ( ⁇ 5 nm), 497-528 nm ( ⁇ 2 nm) and 565-695 nm ( ⁇ 5 nm).
- the spectral filter is configured to block 80-100% of the spectral content in each of the contiguous blocking regions.
- FIG. 1 illustrates example spectral characteristics of dye-based (left) and pigment-based (right) filters.
- FIG. 2A illustrates the solar radiation spectrum
- FIG. 2B illustrates the radiation spectrum of an example light emitting diode (LED).
- LED light emitting diode
- FIG. 2C illustrates the spectrum of an example halogen lamp.
- FIG. 3 illustrates a typical spectral sensitivity of the human eye.
- FIG. 4A is a plot of the transmission spectra for a filter specifically designed to restore circadian rhythm in accordance with an example embodiment.
- FIG. 4B illustrates a set of parameters associated with the filter of FIG. 4A.
- FIG. 5A is a plot of the transmission spectra for a filter specifically designed to restore circadian rhythm in accordance with another example embodiment.
- FIG. 5B illustrates a set of parameters associated with the filter of FIG. 5A.
- FIG. 6 illustrates an example eyewear that incorporates the circadian rhythm restoring filters of the disclosed technology.
- the timing of the brain's circadian clock is set by schedules of natural sunlight exposure. All physiological processes in the body are synchronized to the signals sent from the brain's clock as it interprets these environmental light patterns. As such, the clock's estimation of whether it is daytime (presence of light) or nighttime (near absence of light) has widespread impacts on the timing and organization of the sleep-wake cycle. Electric room lighting can interfere with the circadian clock's estimation of day versus night because the photoreceptors in the eye that send information to the clock are activated by both natural sunlight and electric room lighting. Electric lighting can thus interfere with sleep because humans are most biologically prepared to sleep at night not during the day. If the clock interprets a daytime signal when sensing electric light, it will delay the timing of sleep and will have more difficulty communicating with the rest of the body so that a consolidated period of rest is coordinated at night.
- the photoreceptors that transmit light information to the brain's clock are most sensitive to certain parts of the light spectrum.
- One photoreceptor, melanopsin, is expressed by a subpopulation of cells in the eye called intrinsically photosensitive retinal ganglion cells (ipRGCs).
- the circuitry that comprises the brain's clock is different from the circuitry that comprises the image-forming visual system (i.e. , the system that allows us to see).
- Current lens technologies that seek to limit the sleep-disrupting effects of electric lighting at night, take advantage of this segregation by filtering out all incident light below approximately 560 nm and allowing the rest through to enable visibility. This approach blocks about 50% of circadian-active light, while maintaining approximately 80% visibility.
- a large number of the existing systems rely on dye- or pigment- based filters that block or transmit a contiguous band of wavelengths but without a capability to selectively transmit or block narrower subbands within the larger contiguous band.
- Dye and pigment filters operate based on absorption of light by color dye and pigment embedded in a material such as polymer or sol-gel.
- the transmission spectrum of this type of filter has broad peaks shaped like a Gaussian function with linewidth equal to the inhomogeneous broadening of the materials.
- FIG. 1 illustrates example spectral characteristics of dye-based (left) and pigment-based (right) filters that exhibit this type of behavior.
- each spectrum includes a prominent peak with gradual fall off characteristics on both sides thereof.
- the usefulness of these filters can be limited to applications where the desired spectral range happens to coincide with the spectral peak of the filter. But even then, the gradual falloff of the spectra can cause part of the desired spectrum to be filtered while allowing part of the undesired spectral content to seep through.
- the materials can be bleached under high light intensity, high temperature and/or corrosive environment.
- filters include doped glass, semiconductor, metal, and metamaterial optical filters.
- Doped glass filters are made of a glass doped with a trace of impurity such as a metal and semiconductor nanocrystal, silver halides and cuprous ions.
- Semiconductor optical filters are made of semiconductor material with a transmission edge determined by the bandgap.
- Metal optical filters are made by depositing several layers of metal or metallic alloy made of rhodium, palladium, tungsten, nickel and chromium on a transparent substrate and are used extensively as neutral density filters.
- Metamaterial optical filters are made of micro- and nano- fabricated structures with dimensions of the order of or smaller than the operating wavelength.
- optical filters are tunable optical filters with transmission spectra that can be changed by temperature, electric and/or magnetic field.
- tunable optical filters are liquid crystal, Fabry-Perot and MEMS filters. These types of filters are generally bulky and have lower transmission than non-tunable filters.
- the disclosed embodiments rely on interference filter designs that are implemented in a wearable device (e.g., glasses, virtual reality goggles, etc.) or used as a covering for a luminaire (e.g., a light source from a house lamp) that provide a more precise and granular spectral behavior in that they allow specific spectral band or bands to be blocked and specific band or bands to be transmitted within a larger spectral bandwidth.
- a wearable device e.g., glasses, virtual reality goggles, etc.
- a luminaire e.g., a light source from a house lamp
- the disclosed devices and methods can further allow other spectral bands that are completely blocked by some prior systems to be transmitted.
- Such a strategy which would enhance visibility while restricting similar levels of circadian-active light, can be implemented by only blocking the most circadian-active blue and green light occurring between 455-495 and 530- 560 nm.
- the result of this more precise targeting of circadian-active light is that about half the spectrum that is blocked by existing lens technology between 400-560 nm is freed up to improve visibility.
- the spectral content between 365 and 400 nm, the so-called ultraviolet-A (UVA) portion of the light spectrum is removed. Humans express UVA-sensitive photoreceptors in the eye that could impact retinal function.
- UVA photoreceptors have yet to be definitively implicated in the workings of the brain's circadian clock, they can impact the clock function by impacting how the retina processes circadian-active light at 455-495 nm and 530-560 nm.
- Multi layer dielectric or dichroic filters operate by optical interference instead of absorption. These filters are made by depositing multiple layers of dielectric coating such as magnesium fluoride, zinc sulfide, cerium dioxide, titanium dioxide, silicon oxide, zirconium dioxide to name a few. Interference filters can be designed to transmit light of different wavelength band with sharp transmission edge, in contrast to the broad band spectrum of the dye and pigment filter. The transmission spectrum of this type of filter is generally dependent on the angle of the incident light, although designs can be made to minimize the angular variation.
- a long-wave pass interference filter can include a multilayer structure and can be described using the following shorthand notation:
- H denotes a quarter-wave high-index layer having a thickness l 0 / n H and — denotes half of a quarter-wave high-index layer, i.e., one- eighth of a wave l 0 /8h H .
- L denotes a quarter-wave low-index layer having a thickness 0/4n L s is an integer that denotes the number of basic periods (i.e., how many times the basis structure of high-low-high is repeated), l 0 is the reference wavelength (i.e., the center wavelength used to design the filter), and n H L represents the high or the low refractive index, depending on whether the H or L subscript is used.
- a short-wave pass interference filter can include a multilayer structure and can be described by the following notation that follows a similar convention as described above:
- a bandpass filter is a combination of long-wave pass and short-wave pass filters, and allows only a particular spectral band (i.e. , the passband) to be transmitted.
- a notch filter blocks a particular band of wavelengths (i.e., the notch) but allows the remaining spectral content to pass therethrough.
- a notch filter can be implemented by using a multilayer structure, represented by the following notation:
- a and b are numbers chosen for the location and width of the notch filter.
- a notch filter with a reference wavelength at 550 nm and bandwidth of about 100 nm can be implemented using the multilayer structure represented by:
- One key advantage of the disclosed embodiments is the selective transmission and blocking of different wavelengths of light to match the photo receptor sensitivity of the human retina with high efficiency that maintains a high visibility.
- the coating on the lens that is part of the eyewear is specifically designed to elicit a particular biological response.
- the optical lens with the coating must satisfy two efficiency conditions: transmission efficiency and illumination efficiency.
- the transmission efficiency of a color filter can be described as:
- h t is the transmission efficiency
- l 1 and l 2 are the lower and upper wavelengths, respectively, of the transmission band
- l 3 and l 4 are the lower and upper wavelengths, respectively, of the incident illumination
- T(A) is the filter transmission spectrum. Interference filters with sharp transition edge and low transmission ripple are used to achieve high h t .
- the illumination efficiency of a color filter can be described as:
- S(A) can be the spectrum of the sun, a light emitting diode (LED), a halogen lamp, a fluorescent lamp, or another source of illumination.
- Example spectra of some of the above sources are presented in FIGS. 2A to 2C.
- FIG. 2A illustrates the solar radiation spectrum
- FIG. 2B illustrates the radiation spectrum of an example LED
- FIG. 2C illustrates the spectrum of an example halogen lamp.
- FIG. 3 illustrates a typical spectral sensitivity of the human eye, and in particular, the normalized responsivity spectra for S-, M- and L-cone cells.
- the illumination efficiency of the lens must be high so that light visibility is not critically reduced during day and night.
- the filter is part of a virtual reality and/or augmented reality system.
- the filter is designed to be detachable and can be utilized as part of the system during different time of day.
- FIG. 4A illustrates a plot of the transmission spectra for a filter specifically designed to restore circadian rhythm in accordance with an example embodiment.
- the filter in FIG. 4A blocks (i.e., at nearly 0% transmission) the following spectral bands: (1) 365-400 nm, (2) 455-495 nm, and (3) 530-560 nm, and allows very high transmission (in some embodiments, close to 100%) for spectral bands 405-450 nm ( ⁇ 5 nm), 497-528 nm ( ⁇ 2 nm) and 565-695 nm ( ⁇ 5 nm), as well as for the band above 700 nm.
- the spectral tolerances are selected to block all, or almost all, of the green, blue and UV spectral content while allowing as much of the spectral content in the band 500-530 nm to be transmitted.
- spectral sensitivities of the M and L cone types are highly responsive to the illumination in the 500-530 nm band, and thus illumination in this band improves the visibility and enhances the eye's ability to form images.
- the transmission (or blockage) characteristics of the spectral bands can be modified by changing the number of layers in the design.
- the filter is designed to provide a blockage between 98-100%.
- the blockage can be 95-98%.
- the blockage is 80-95%.
- the transmission is in the range 98-100%.
- the characteristics of the spectral bands can be fine-tuned by adding more layers to the design at the expense of increasing the cost of the filters.
- FIG. 5A illustrates a plot of the transmission spectra for a filter specifically designed to restore circadian rhythm in accordance with an alternate embodiment.
- the filter in FIG. 5 similar to that in FIG. 4, blocks three spectral bands: (1) 365-400 nm, (2) 455-495 nm, and (3) 530-560 nm, and allows nearly full (in some embodiments 100%) transmission for spectral bands 405-450 nm ( ⁇ 5 nm), 497-528 nm ( ⁇ 2 nm) and 565-695 nm ( ⁇ 5 nm).
- the FIG. 5 filter blocks nearly all of the spectral ultraviolet spectrum (i.e., content below 400 nm), which has been associated with the incidence of several diseases of the eye.
- both filters in FIGS. 4A and 5A block the circadian-active blue and green regions occurring in the bands 455-495 nm and 530-560 nm, while allowing nearly 100% transmission in the band 495-530 nm therebetween, and other pass bands such as the band 560-700 nm that are carved out with surgical precision.
- This added transmission capability in regions where the human eye is spectrally sensitive provides added visibility of the scenes that are being viewed and improves the user experience in wearing the specialized glasses or goggles.
- total light transmission is improved by 20-100%, depending on the source of illumination.
- the filter allows nearly 50% more irradiance to reach the cornea under cloudy daylight conditions compared to existing designs.
- FIGS. 4A and 5A block the UVA region (between 365-400 nm), which as noted earlier, can contribute to the workings of the part of the retina that sends information to the brain's circadian clock.
- the filters in FIGS. 4A and 5A can also be designed to provide the spectral characteristics for a substrate that is different than glass.
- the filters may also include an anti-reflection coating on the back side.
- Another feature of the disclosed filters is their ability to provide nearly optimum performance for all illumination sources with broadband or relatively broadband spectra.
- the filter passbands and notches are designed to precisely coincide with, and have sharp edges, in circadian-sensitive bands. Therefore, they provide optimum performance by only blocking out the portions of the illumination spectra responsible for disruptions in the circadian rhythm.
- FIG. 6 illustrates a pair of example glasses that includes a pair of lenses 603 that can be coated with the disclosed filters.
- the glasses can include opaque side shields or blocks (not shown) to prevent side illumination to reach the eye.
- the side shields can be transparent and include filters with similar transmission and blocking characteristic as those on the lenses 603.
- the disclosed filters can be implemented as a coating provided on other types of eyewear, such as virtual reality goggles.
- the wearable device can include a unitary transparent window that can be coated uniformly, or at particular locations thereon, with the disclosed filters having transmission and blockage characteristics at precisely tailored bands of the spectrum.
- the particular locations of coatings can be selected to affect light that reaches the user's eyes at approximately normal angles.
- the coatings' locations and areal extent can be chosen to filter the light that reaches the user's eyes at both normal and inclined angles.
- the filters can be made detachable to existing eye wear, for example by small magnets or by screw- in adapter.
- One aspect of the disclosed technology relates to a wearable device for viewing a real or virtual environment that includes one or more windows positioned to allow light from the real or virtual environment to reach a wearer's eyes, and a spectral filter that comprises a coating positioned on one or more sections of the one or more windows.
- the spectral filter includes a multi-layer stack of dielectric material with alternate high and low indices of refraction such that a layer having a high index of refraction is positioned above or below a layer having a low index of reflection, and a layer having a high index of refraction is positioned above or below a layer having a low index of reflection.
- the number of the layers and thickness of each layer are selected to provide designed transmission and blocking characteristics to block circadian-rhythm-disruptive spectra from reaching the wearer's eyes while providing viewability of the real or virtual environment by allowing light outside of the circadian- rhythm-disruptive spectra to reach the wearer's eyes.
- the designed transmission and blocking characteristics include three contiguous blocking regions at 365-400 nm, 455- 495 nm, and 530-560 nm bands of wavelengths, and three contiguous transmission regions at 405-450 nm band of wavelengths with a tolerance range of ⁇ 5 nm, 497- 528 nm band of wavelengths with a tolerance range of ⁇ 2 nm and 565-695 nm band of wavelengths with a tolerance range of ⁇ 5 nm.
- the spectral filter is configured to block 80-100% of the spectral content in each of the contiguous blocking regions.
- each of the contiguous transmission regions transmits 80-100% of the spectral content in the corresponding transmission region.
- the designed transmission and blocking characteristics include a blocking region that extends above 700 nm.
- the multi-layer stack includes 87 layers.
- each layer with the high index of refraction includes titanium dioxide (T1O2) and has a 2.35 index of refraction
- each layer with the low index of refraction includes silicon dioxide (S1O2) and has a 1.45 index of refraction
- the designed transmission and blocking characteristics include a blocking region that extends from 250 nm to 400 nm.
- each layer with the high index of refraction includes titanium dioxide (T1O2) and has a 2.35 index of refraction
- each layer with the low index of refraction includes silicon dioxide (S1O2) and has a 1.45 index of refraction
- the multilayer stack includes 122 layers.
- the one or more windows include two lenses, and the spectral filter is formed as the coating on each of the lenses.
- the wearable device is a pair of goggles, the one or more windows form a unitary window, and the spectral filter is formed as the coating on the unitary window.
- the wearable device is a pair of goggles, the one or more windows form a unitary window, and the spectral filter is formed as the coating on two or more sections of the unitary window.
- the wearable device is a pair of virtual reality goggles.
- the one or more windows are made of glass or plastic.
- the spectral filter is removably attached to the one or more windows.
- the designed transmission and blocking characteristics produce optimum blockage of circadian- rhythm -disruptive light for broadband illumination or ambient lighting conditions.
- a spectral filter for use in an eyewear for restoring circadian rhythm that incudes a multi-layer stack coating on a substrate.
- the multi-layer stack includes a plurality of layers of dielectric material with alternate high and low indices of refraction such that a layer having a high index of refraction is positioned above or below a layer having a low index of reflection, and a layer having a high index of refraction is positioned above or below a layer having a low index of reflection.
- the number of the layers and a thickness of each layer are selected to provide designed transmission and blocking characteristics to block circadian-rhythm-disruptive spectra from passing through the spectral filter.
- the designed transmission and blocking characteristics include three contiguous blocking regions at 365-400 nm, 455-495 nm, and 530-560 nm bands of wavelengths, and three contiguous transmission regions at 405-450 nm band of wavelengths with a tolerance range of ⁇ 5 nm, 497-528 nm band of wavelengths with a tolerance range of ⁇ 2 nm and 565-695 nm band of wavelengths with a tolerance range of ⁇ 5 nm.
- Each of the contiguous blocking regions blocks 80-100% of the spectral content in the corresponding blocking region, and each of the contiguous transmission regions transmits 98-100% of the spectral content in the corresponding transmission region.
- the designed transmission and blocking characteristics include a blocking region that extends above 700 nm.
- each layer with the high index of refraction includes titanium dioxide (PO2) and has a 2.35 index of refraction
- each layer with the low index of refraction includes silicon dioxide (S1O2) and has a 1.45 index of refraction.
- the designed transmission and blocking characteristics include a blocking region that extends from 250 nm to 400 nm.
- each layer with the high index of refraction includes titanium dioxide (PO2) and has a 2.35 index of refraction
- each layer with the low index of refraction includes silicon dioxide (S1O2) and has a 1.45 index of refraction
- the multilayer stack includes 122 layers.
- the multi-layer stack includes 87 layers.
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Abstract
Description
Claims
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18/292,292 US20250093684A1 (en) | 2021-07-26 | 2022-07-25 | Circadian rhythm restoring blue blockers |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163225727P | 2021-07-26 | 2021-07-26 | |
| US63/225,727 | 2021-07-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2023009448A1 true WO2023009448A1 (en) | 2023-02-02 |
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ID=85087946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2022/038207 Ceased WO2023009448A1 (en) | 2021-07-26 | 2022-07-25 | Circadian rhythm restoring blue blockers |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US20250093684A1 (en) |
| WO (1) | WO2023009448A1 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170363884A1 (en) * | 2014-12-05 | 2017-12-21 | 3M Innovative Properties Company | Vision-protecting filter lens |
| US20190324179A1 (en) * | 2018-04-24 | 2019-10-24 | Palo Alto Research Center Incorporated | Angle-insensitive multi-wavelength optical filters with hue control |
| WO2021096840A1 (en) * | 2019-11-11 | 2021-05-20 | Dreamers Holdings, Llc | Sleep-aiding eyewear with improved visibility |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5996563B2 (en) * | 2011-03-03 | 2016-09-21 | エンクロマ, インコーポレイテッド | Multi-band color vision filter and LP optimization method |
| BR112015016719A2 (en) * | 2013-01-14 | 2017-07-11 | 3M Innovative Properties Co | filter, correction or eye protection device, and color discrimination optimization method |
| US10857382B2 (en) * | 2016-06-03 | 2020-12-08 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions and methods for treating and preventing chronic pain |
-
2022
- 2022-07-25 US US18/292,292 patent/US20250093684A1/en active Pending
- 2022-07-25 WO PCT/US2022/038207 patent/WO2023009448A1/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170363884A1 (en) * | 2014-12-05 | 2017-12-21 | 3M Innovative Properties Company | Vision-protecting filter lens |
| US20190324179A1 (en) * | 2018-04-24 | 2019-10-24 | Palo Alto Research Center Incorporated | Angle-insensitive multi-wavelength optical filters with hue control |
| WO2021096840A1 (en) * | 2019-11-11 | 2021-05-20 | Dreamers Holdings, Llc | Sleep-aiding eyewear with improved visibility |
Also Published As
| Publication number | Publication date |
|---|---|
| US20250093684A1 (en) | 2025-03-20 |
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