WO2022215619A1 - Ｇｌｐ－１分泌促進用組成物 - Google Patents

Ｇｌｐ－１分泌促進用組成物 Download PDF

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Publication number
WO2022215619A1
WO2022215619A1 PCT/JP2022/015872 JP2022015872W WO2022215619A1 WO 2022215619 A1 WO2022215619 A1 WO 2022215619A1 JP 2022015872 W JP2022015872 W JP 2022015872W WO 2022215619 A1 WO2022215619 A1 WO 2022215619A1
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WO
WIPO (PCT)
Prior art keywords
composition
component
secretion
glp
thymol
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Ceased
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PCT/JP2022/015872
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English (en)
French (fr)
Japanese (ja)
Inventor
遵 高橋
未佳 山田
紀恵 新井
英美子 橋新
仁志 三皷
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Nagase Viita Co Ltd
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Hayashibara Co Ltd
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Priority to US18/553,882 priority Critical patent/US20240139226A1/en
Priority to JP2023512977A priority patent/JPWO2022215619A1/ja
Priority to EP22784603.7A priority patent/EP4309515A4/en
Publication of WO2022215619A1 publication Critical patent/WO2022215619A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00—Tea; Tea substitutes; Preparations thereof
    • A23F3/16—Tea extraction; Tea extracts; Treating tea extract; Making instant tea
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00—Tea; Tea substitutes; Preparations thereof
    • A23F3/40—Tea flavour; Tea oil; Flavouring of tea or tea extract
    • A23F3/405—Flavouring with flavours other than natural tea flavour or tea oil
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F5/00—Coffee; Coffee substitutes; Preparations thereof
    • A23F5/24—Extraction of coffee; Coffee extracts; Making instant coffee
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F5/00—Coffee; Coffee substitutes; Preparations thereof
    • A23F5/24—Extraction of coffee; Coffee extracts; Making instant coffee
    • A23F5/26—Extraction of water soluble constituents
    • A23F5/267—Extraction of water soluble constituents using additives, specific extraction media or specific coffee blends
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G9/00—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor
    • A23G9/32—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor characterised by the composition containing organic or inorganic compounds
    • A23G9/36—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
    • C12G3/00—Preparation of other alcoholic beverages
    • C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
    • C12G3/05—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs with health-improving ingredients, e.g. flavonoids, flavones, polyphenols or polysaccharides

Definitions

  • Endocrine cells are scattered in the intestinal epithelium, and it is known that gastrointestinal hormones secreted from these intestinal endocrine cells regulate the functions of other organs. Some of the gastrointestinal hormones secreted from endocrine cells, also called incretins, are secreted into the blood with meal intake and act on ⁇ cells of the islets of Langerhans in the pancreas (hereinafter referred to as “pancreatic ⁇ cells”) to produce insulin. Promotes secretion.
  • component (A) glycosylnaringenin
  • component (B) ⁇ -pinene, ⁇ -pinene, sabinene, camphene, valencene, ⁇ -caryophyllene, ⁇ -ionone, methyl anthranilate, methyl N-methylanthranilate, thymol and nootkatone as an active ingredient.
  • component (A) and component (B) which are active ingredients of the composition of the present invention, will be described in order.
  • Typical compounds included in the term "glycosyl naringenin” as used herein include “naringin ” (chemical formula 2 below), and “3′′- ⁇ -monoglucosyl naringin” (chemical formula 3 below) having a structure in which glucose is ⁇ -bonded to the 3-position (3′′) OH group of the glucose residue in neohesperidose of naringin. etc.
  • Naringin for example, is contained in immature peels of citrus fruits and is a substance having an antioxidant effect. In addition to physiological actions such as strengthening capillaries, preventing bleeding, regulating blood pressure and lowering cholesterol, it maintains the homeostasis of the body. It has also been found to have TNF inducing activity.
  • the dosage, administration route, administration interval, intake amount, or intake interval of the composition for promoting GLP-1 secretion of the present invention are appropriately set according to the body weight, sex, age, condition, or other factors of the subject of administration or intake.
  • the intake or dosage is, for example, 0.1 to 500 mg, preferably 1 to 300 mg, more preferably 2 to 200 mg as glycosylnaringenin per day for an adult (body weight 60 kg). , more preferably 5 to 150 mg.
  • Acidulants include, for example, benzoic acid, adipic acid, sorbic acid, citric acid, trisodium citrate, gluconodeltalactone, gluconic acid, potassium gluconate, sodium gluconate, succinic acid, monosodium succinate, Disodium succinate, sodium acetate, DL-tartaric acid, L-tartaric acid, DL-sodium tartrate, sodium L-tartrate, lactic acid, sodium lactate, acetic acid, fumaric acid, monosodium fumarate, DL-malic acid, DL-malic acid Examples include sodium, phosphoric acid, malic acid, itaconic acid, ⁇ -ketoglutaric acid, phytic acid, disodium dihydrogen pyrophosphate, sodium metaphosphate, vinegar and fruit juice.
  • Examples of food flavors include citrus flavors such as orange, lemon, lime, grapefruit, mandarin, and tangerine, shikuwasha, yuzu, mandarin orange, citrus, bergamot, iyokan, kabosu, bitter orange, buntan, kumquat, sudachi, and ponkan; apple , banana, cherry, grape, melon, peach, pineapple, plum, cranberry, and strawberry; Beans flavors, such as vanilla, coffee, cocoa, and chocolate; mint flavors, such as peppermint, spearmint, and horsemint Flavors; Spicy flavors such as allspice, cinnamon, and nutmeg; Nut flavors such as almonds, peanuts, and walnuts; Seafood flavors such as crab, shrimp, and other seafood; Other vegetables, grains, seaweed, etc. Various flavors of can be exemplified.
  • xanthan gum e.g., locust bean gum, guar gum, tara gum, etc.
  • galactomannans e.g., locust bean gum, guar gum, tara gum, etc.
  • psyllium seed gum e.g., locust bean gum, guar gum, tara gum, etc.
  • psyllium seed gum e.g., psyllium seed gum, wormwood seed gum, sesbania gum, tamarind seed gum, gellan gum, deacylated gellan gum, native gellan gum, carrageenan, glucomannan, Konjac powder, macrohomopsis gum, arabinogalactan, elemi resin, karaya gum, dammar resin, tragacanth gum, peach resin, amaseed gum, cassia gum, tricanthus gum, agar, gelatin, pectin (e.g.
  • reaction solution containing ⁇ -glycosylnaringin.
  • this reaction solution is adjusted to pH 4.5, 100 units of glucoamylase (trade name: Glucozyme (manufactured by Amano Enzyme Co., Ltd.)) is added per 1 g of dextrin, and the mixture is reacted at 55°C for 24 hours to obtain ⁇ - alpha-glucosylnaringin was produced from glycosylnaringin.
  • glucoamylase trade name: Glucozyme (manufactured by Amano Enzyme Co., Ltd.)
  • ⁇ Energy drink> As an amino acid mixture, 4 parts by mass of isoleucine, 6 parts by mass of leucine, 8 parts by mass of lysine, 8 parts by mass of phenylalanine, 1 part by mass of tyrosine, 12 parts by mass of tryptophan, 8 parts by mass of valine, 1 part by mass of aspartic acid, 1 part by mass of serine, A mixture of 8 parts by weight of aminoacetic acid, 8 parts by weight of alanine, 2 parts by weight of histidine, 8 parts by weight of arginine, 2 parts by weight of threonine, and 1 part by weight of methionine was prepared and dissolved in water to prepare a 2% solution of the mixture.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PCT/JP2022/015872 2021-04-07 2022-03-30 Ｇｌｐ－１分泌促進用組成物 Ceased WO2022215619A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US18/553,882 US20240139226A1 (en) 2021-04-07 2022-03-30 A composition for promoting glp-1 secretion
JP2023512977A JPWO2022215619A1 (https=) 2021-04-07 2022-03-30
EP22784603.7A EP4309515A4 (en) 2021-04-07 2022-03-30 COMPOSITION PROMOTING THE SECRETION OF GLP-1

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2021-065419 2021-04-07
JP2021065419 2021-04-07

Publications (1)

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WO2022215619A1 true WO2022215619A1 (ja) 2022-10-13

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US (1) US20240139226A1 (https=)
EP (1) EP4309515A4 (https=)
JP (1) JPWO2022215619A1 (https=)
TW (1) TW202304312A (https=)
WO (1) WO2022215619A1 (https=)

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EP4609727A4 (en) * 2022-10-28 2026-03-04 Nagase Viita Co Ltd Composition for improving mouthfeel, food/beverage product composition and method for producing same, and method for improving mouthfeel

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WO2024123824A1 (en) * 2022-12-05 2024-06-13 Enveda Therapeutics, Inc. Nootkatone for the treatment of pruritus

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