WO2022210606A1 - Method for evaluating future risk of developing dementia - Google Patents

Method for evaluating future risk of developing dementia Download PDF

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WO2022210606A1
WO2022210606A1 PCT/JP2022/015191 JP2022015191W WO2022210606A1 WO 2022210606 A1 WO2022210606 A1 WO 2022210606A1 JP 2022015191 W JP2022015191 W JP 2022015191W WO 2022210606 A1 WO2022210606 A1 WO 2022210606A1
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ile
gln
tyr
leu
lys
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PCT/JP2022/015191
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French (fr)
Japanese (ja)
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健 池内
由紀 矢野
麻優香 神田
和 佐藤
直子 嵐田
幸聖 唐川
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味の素株式会社
国立大学法人新潟大学
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Priority to KR1020237033394A priority Critical patent/KR20230163420A/en
Priority to JP2023511305A priority patent/JPWO2022210606A1/ja
Publication of WO2022210606A1 publication Critical patent/WO2022210606A1/en

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4869—Determining body composition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records

Definitions

  • the present invention relates to an evaluation method, a calculation method, an evaluation device, a calculation device, an evaluation program, a calculation program, a recording medium, an evaluation system, and a terminal device for the future onset risk of dementia.
  • Dementia refers to a condition in which normally developed intellectual function is impaired in general and persistently due to acquired brain lesions, resulting in difficulty in daily life. , memory, thinking, orientation, comprehension, calculation, learning, language, judgment, etc.” syndrome” (Non-Patent Document 1). Alzheimer's disease (hereinafter sometimes referred to as AD) accounts for the highest proportion of about 60% of the multiple diseases that cause dementia.
  • Typical neuropathological features of AD include senile plaques and neurofibrillary tangles in the brain.
  • the cause of senile plaques is the deposition of a protein called amyloid ⁇ (A ⁇ ), and the cause of neurofibrillary tangles is known to be hyperphosphorylated tau protein.
  • a ⁇ amyloid ⁇
  • SPECT single photon emission computed tomography
  • Non-Patent Documents 3 and 4 a diagnostic technique for AD using the concentrations of A ⁇ and phosphorylated tau protein in cerebrospinal fluid (CSF) as indices has been provided.
  • acetylcholinesterase inhibitors and NMDA (N-methyl-D-aspartic acid) receptor inhibitors are used as therapeutic agents for AD, but both of these drugs only have the effect of delaying the progression of symptoms for a certain period of time. Therefore, no pathophysiological modification therapy required for radical treatment has been established yet.
  • Antibody drugs and the like have also been developed based on neuropathological findings such as the accumulation of A ⁇ and phosphorylated tau protein, but it is becoming clear that they are not effective for post-onset patients. Therefore, in recent years, it is generally thought that it is appropriate to target the stage prior to the onset of AD for intervention.
  • MCI Mild Cognitive Impairment
  • FTD frontotemporal dementia
  • Non-Patent Document 7 a treatment policy suitable for the pathology only from clinical symptoms at the stage of MCI. Therefore, for MCI populations showing cognitive decline against the background of various diseases, onset prediction technology (for example, AD By providing onset prediction technology that determines whether or not it will develop, that is, MCI due to Alzheimer's pathology (MCI due to AD), etc.), it will be useful for selecting appropriate intervention and treatment from an early stage It is expected.
  • onset prediction technology for example, AD By providing onset prediction technology that determines whether or not it will develop, that is, MCI due to Alzheimer's pathology (MCI due to AD), etc.
  • AD diagnostic imaging methods such as amyloid PET and tau PET, which are used as AD diagnostic techniques, as indicators for predicting the onset of AD. It is not realistic to have a patient undergo a highly invasive examination. Therefore, a simpler and cheaper screening test technique is required.
  • Patent Documents 1, 2, and 3 a technique for determining MCI by a blood test
  • Patent Document 4 a technique for measuring the peptide fragment concentration in blood and using it as an index
  • test items blood count test items and biochemical test items may be collectively referred to as "test items”.
  • An object of the present invention is to provide an evaluation program, a calculation program, a recording medium, an evaluation system, and a terminal device.
  • the evaluation method according to the present invention includes concentration values of 19 amino acids in the blood to be evaluated, values of 25 amino acid-related metabolites in the blood ( concentration value or area value), test values of the 13 types of test items in the blood, and at least one value of the two types of physical characteristics (BMI (Body Mass Index) and body weight) to be evaluated, Alternatively, using a formula containing a variable to which the at least one value is substituted and the value of the formula calculated using the at least one value, the evaluation of evaluating the risk of developing dementia in the future for the subject. characterized by comprising a step.
  • the 19 kinds of amino acids are Ala, Arg, Asn, Cit, Gln, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, and Val. .
  • various amino acids are mainly abbreviated, but their official names are as follows.
  • the 25 amino acid-related metabolites are 3h-Kyn, 5h-Indole-3-acetic acid, Anthranilic acid, Indol-3-acetic acid, Indole-3-lactic acid, Kynurenic acid, Picolinic acid, Quinolinic acid , Serotonin, Xanthurenic acid, Neopterin, 1-Mehis, 3-Mehis, ADMA, b-AiBA, Cystathionine, GABA, hArg, Kyn, N6-acetyl-L-lysine, N8-acetyl-spd, SDMA, Thioproline, aABA, and Spd.
  • test items are WBC, RBC, Hb, Ht, folic acid, LDLC, Alb, prealbumin, CRP, TG, uric acid, ⁇ GTP, and HbA1c.
  • abbreviated names various inspection items are mainly described by abbreviated names, but their official names are as follows.
  • abbreviation (formal name) WBC white blood cell count RBC red blood cell count Hb hemoglobin content Ht Hematocrit value LDLC Low-density lipoprotein cholesterol Alb Albumin CRP C-reactive protein TG Triglyceride ⁇ GTP ⁇ -glutamyl transpeptidase HbA1c Hemoglobin A1c
  • the evaluation step includes the sum of the concentration values of Val, Leu, and Ile and the value of a categorical variable related to the possession of the APOE allele, or the variable into which the sum is substituted and the Using a formula containing a variable to which the value of the categorical variable is substituted, the sum, and the value of the formula calculated using the value of the categorical variable, the future of dementia for the evaluation subject characterized by evaluating the onset risk of
  • the value of a binary variable (dummy variable) regarding the presence or absence of the APOE ⁇ 4 allele may be used as the value of the categorical variable.
  • the value of the number of APOE ⁇ 4 alleles contained in the APOE genotype (0, 1, or 2) may be used as the value of the categorical variable.
  • six classifications of APOE genotypes based on three isoforms for the APOE gene (( ⁇ 2 allyl, ⁇ 2 allyl), ( ⁇ 3 allyl, ⁇ 3 allyl), ( ⁇ 4 allyl, ⁇ 4 allyl), ( ⁇ 2 allyl, ⁇ 3 allyl), ( ⁇ 2 allyl, ⁇ 4 allyl), and ( ⁇ 3 allyl, ⁇ 4 allyl)) may be used as values of categorical variables.
  • the gene is referred to as APOE, but its formal name is apolipoprotein E.
  • an examination step of examining the ApoE gene using the biological sample to be evaluated and determining the value of the categorical variable based on the ApoE genotype obtained in the examination step. and, in the evaluating step, the value of the categorical variable is the value determined in the determining step.
  • the evaluation target does not possess the APOE ⁇ 4 allele
  • the evaluation step includes Ala, Arg, Asn, Cit, Gln, Gly, His, Ile, Leu, Lys, Met , Orn, Phe, Pro, Ser, Thr, Trp, Tyr, and Val and the sum of the concentration values of Val, Leu, and Ile, or the at least one value is Using the formula containing the variables to be substituted and the value of the formula calculated using the at least one value, the risk of future development of dementia is evaluated for the evaluation subject. .
  • an examination step of examining the ApoE gene using the biological sample to be evaluated and a confirmation step of confirming whether or not the subject is confirmed to have the APOE ⁇ 4 allele in the evaluation step.
  • the evaluation step is characterized by being executed by the control section of an information processing apparatus having a control section.
  • the calculation method according to the present invention includes concentration values of the 19 types of amino acids in the blood to be evaluated, values of the 25 types of amino acid-related metabolites in the blood, and the 13 types of test items in the blood. and at least one value of the two physical characteristic values to be evaluated, and a variable into which the at least one value is assigned, for evaluating the risk of future onset of dementia is characterized by including a calculation step of calculating the value of the formula using the formula:
  • the calculation step includes: the sum of the concentration values of Val, Leu, and Ile; the value of a categorical variable related to the possession of the APOE allele; and a variable into which the value of the Cull variable is substituted, and the value of the formula is calculated using a formula for evaluating the risk of developing dementia in the future.
  • the evaluation target does not have the APOE ⁇ 4 allele
  • the calculation step includes Ala, Arg, Asn, Cit, Gln, Gly, His, Ile, Leu, Lys, Met , Orn, Phe, Pro, Ser, Thr, Trp, Tyr, and Val and the sum of the concentration values of Val, Leu, and Ile, and the at least one value is
  • a formula for evaluating the future risk of dementia including the variables to be substituted is used to calculate the value of the formula.
  • the calculation step is characterized by being executed by the control section of an information processing apparatus having a control section.
  • the evaluation apparatus is an evaluation apparatus comprising a control unit, wherein the control unit controls the concentration values of the 19 amino acids in the blood to be evaluated, the 25 amino acid-related At least one value of the values of metabolites, the test values of the 13 types of test items in the blood, and the values of the two types of physical characteristics to be evaluated, or the at least one value is substituted Using a formula containing a variable and the value of the formula calculated using the at least one value, an evaluation means is provided for evaluating the future risk of developing dementia for the evaluation subject.
  • the evaluation device is communicably connected via a network to a terminal device that provides the at least one value or the value of the expression, and the control unit receives a data receiving means for receiving the at least one value or the value of the formula; and result transmitting means for transmitting the evaluation result obtained by the evaluating means to the terminal device, wherein the evaluating means The at least one value received by the data receiving means or the value of the formula is used.
  • the calculation device is a calculation device comprising a control unit, wherein the control unit controls the concentration values of the 19 amino acids in the blood to be evaluated, the 25 amino acid-related At least one value among the values of metabolites, the test values of the thirteen test items in the blood, and the two physical characteristic values of the evaluation object, and the at least one value are substituted. and calculating means for calculating the value of the formula using a formula for evaluating the risk of developing dementia in the future, including the variables.
  • an evaluation program is an evaluation program to be executed by an information processing apparatus having a control unit, wherein the concentration of the 19 types of amino acids in the blood to be evaluated is to be executed by the control unit. values of the 25 types of amino acid-related metabolites in the blood; test values of the 13 types of test items in the blood; and values of the two types of physical characteristics to be evaluated. value, or the formula containing the variable to which the at least one value is substituted and the value of the formula calculated using the at least one value, dementia for the subject to evaluate the risk of developing future dementia and including an evaluation step for
  • a calculation program is a calculation program to be executed in an information processing apparatus having a control unit, and is a calculation program for executing in the control unit, the concentration of the 19 amino acids in the blood to be evaluated. values of the 25 types of amino acid-related metabolites in the blood; test values of the 13 types of test items in the blood; and values of the two types of physical characteristics to be evaluated. and a formula for evaluating the risk of future development of dementia that includes a variable into which the at least one value is substituted, and a calculating step of calculating the value of the formula. .
  • a recording medium is a non-transitory computer-readable recording medium, characterized by including programmed instructions for causing an information processing device to execute the evaluation method or the calculation method.
  • an evaluation system is an evaluation system configured by connecting an evaluation device having a control unit and a terminal device having a control unit so as to be communicable via a network, wherein the control of the terminal device
  • the part is the concentration values of the 19 amino acids in the blood to be evaluated, the values of the 25 amino acid-related metabolites in the blood, the test values of the 13 test items in the blood, and the evaluation At least one value of the two types of physical characteristic values of the subject, or a formula including a variable into which the at least one value is substituted and the value of the formula calculated using the at least one value data transmission means for transmitting data to the evaluation device; and result reception means for receiving an evaluation result regarding the future risk of developing dementia for the evaluation target, which is transmitted from the evaluation device;
  • the control unit uses data receiving means for receiving the at least one value or the value of the formula transmitted from the terminal device, and the at least one value or the value of the formula received by the data receiving means. and evaluation means for evaluating the future risk of developing dementia for the evaluation object, and
  • a terminal device is a terminal device comprising a control unit, wherein the control unit comprises result acquisition means for acquiring an evaluation result regarding the risk of developing Alzheimer's disease in the future for an evaluation target.
  • the evaluation results include concentration values of the 19 types of amino acids in the blood of the evaluation object, values of the 25 types of amino acid-related metabolites in the blood, and test values of the 13 types of test items in the blood. , and at least one value of the two types of physical characteristic values to be evaluated, or an expression containing a variable into which the at least one value is substituted and the at least one value calculated using the It is characterized by being the result of evaluating the future risk of developing dementia for the evaluation object using the value of the formula.
  • the terminal device is communicably connected via a network with an evaluation device that evaluates the risk of future development of dementia for the evaluation object, and the control unit controls the at least one value or
  • the method further comprises data transmission means for transmitting the value of the expression to the evaluation device, and the result acquisition means receives the evaluation result transmitted from the evaluation device.
  • FIG. 1 is a principle configuration diagram showing the basic principle of the first embodiment.
  • FIG. 2 is a principle configuration diagram showing the basic principle of the second embodiment.
  • FIG. 3 is a diagram showing an example of the overall configuration of this system.
  • FIG. 4 is a diagram showing another example of the overall configuration of this system.
  • FIG. 5 is a block diagram showing an example of the configuration of the evaluation device 100 of this system.
  • FIG. 6 is a diagram showing an example of information stored in the measurement data file 106a.
  • FIG. 7 is a diagram showing an example of information stored in the index state information file 106b.
  • FIG. 8 is a diagram showing an example of information stored in the specified index state information file 106c.
  • FIG. 9 is a diagram showing an example of information stored in the formula file 106d1.
  • FIG. 1 is a principle configuration diagram showing the basic principle of the first embodiment.
  • FIG. 2 is a principle configuration diagram showing the basic principle of the second embodiment.
  • FIG. 3 is a diagram showing an example of
  • FIG. 10 is a diagram showing an example of information stored in the evaluation result file 106e.
  • FIG. 11 is a block diagram showing the configuration of the evaluation unit 102d.
  • FIG. 12 is a block diagram showing an example of the configuration of the client device 200 of this system.
  • FIG. 13 is a block diagram showing an example of the configuration of the database device 400 of this system.
  • an embodiment (first embodiment) of the evaluation method and the calculation method according to the present invention an evaluation device, a calculation device, an evaluation method, a calculation method, an evaluation program, a calculation program, a recording medium, an evaluation system, and a terminal device (second embodiment) will be described in detail with reference to the drawings.
  • this invention is not limited by these embodiments.
  • FIG. 1 is a principle configuration diagram showing the basic principle of the first embodiment.
  • concentration values of the 19 types of amino acids in blood collected from an evaluation subject (for example, individuals such as animals and humans), and the 25 types of amino acid-related metabolites in the blood acquisition of measurement data related to at least one measurement value (concentration value or area value), the test values of the 13 types of test items in the blood, and the characteristic values of the two types of physical characteristics to be evaluated.
  • concentration value or area value concentration value or area value
  • the test values of the 13 types of test items in the blood and the characteristic values of the two types of physical characteristics to be evaluated.
  • step S11 concentration values of the 19 types of amino acids, the values of the 25 types of amino acid-related metabolites, the test values of the 13 types of test items, and the characteristic values of the 2 types of physical characteristics.
  • the subject to be evaluated may be, for example, a healthy subject, a subject with MCI, or a subject evaluated as likely to have MCI by some means such as testing.
  • An evaluation subject with MCI is, for example, a subject diagnosed with MCI based on the existing diagnostic criteria for MCI (for example, Non-Patent Document 4, etc.).
  • step S11 for example, measurement data measured by a company or the like that measures the measurement values may be acquired.
  • measurement data may be obtained by performing measurement using the following measurement methods (A), (B), (C), or (D) from blood collected from an evaluation subject.
  • the unit of the concentration value may be, for example, molar concentration, weight concentration, or enzyme activity, and may be obtained by adding, subtracting, multiplying, or dividing these concentrations by an arbitrary constant.
  • BCP bromocresol purple
  • CLEIA chemiluminescent enzyme immunoassay
  • flow cytometry method using a semiconductor laser sheath flow direct current detection method
  • SLS sodium lauryl sulfate
  • Plasma is separated from the blood by centrifuging the collected blood sample. All plasma samples are stored frozen at ⁇ 80° C. until concentration values are measured.
  • acetonitrile is added to remove proteins, and if necessary, contaminants such as phospholipids are removed by solid phase extraction, etc., and a labeling reagent (3-aminopyridyl-N-hydroxysuccinimide pre-column derivatization with dilucarbamate) and concentration values are analyzed by liquid chromatography mass spectrometry (including tandem mass spectrometry) (WO2003/069328, WO2005/116629 ).
  • B Separating the plasma from the blood by centrifuging the collected blood sample. All plasma samples are stored frozen at ⁇ 80° C. until concentration values are measured.
  • sulfosalicylic acid is added to deproteinize, and then the concentration value is analyzed with an amino acid analyzer based on the principle of the post-column derivatization method using a ninhydrin reagent.
  • C Blood cell separation is performed on the collected blood sample using a membrane, MEMS (Micro Electro Mechanical Systems) technology, or the principle of centrifugation to separate plasma or serum from the blood. Plasma or serum samples that are not subjected to concentration readings immediately after obtaining plasma or serum are stored frozen at -80°C until concentration readings are taken.
  • concentration value measurement molecules such as enzymes and aptamers that react with or bind to target blood substances are used, and concentration values are analyzed by quantifying substances and spectroscopic values that increase or decrease due to substrate recognition.
  • D An internal standard mixed solution and acetonitrile are added to the collected plasma sample, mixed, and then centrifuged. After the obtained supernatant is dried, it is redissolved in purified water to obtain a sample after pretreatment. This sample is quantified by liquid chromatography mass spectrometry (including tandem mass spectrometry). An internal standard method based on peak area is used for quantification.
  • the future risk of developing dementia (for example, AD, DLB, FTD, VaD, etc.) is evaluated for the evaluation target (step S12).
  • Data such as missing values and outliers may be removed from the measurement data acquired in step S11 before executing step S12.
  • evaluating the risk of developing dementia in the future for an object to be evaluated means, for example, predicting or examining the risk of the object to be evaluated developing dementia in the future.
  • the future is, for example, a predetermined period from the time of blood collection (for example, "average period from MCI to AD known in the medical field", or, for example, 3 years, 4 years, 5 years etc., when a period of years, etc.) has passed.
  • step S11 the measurement data of the evaluation target is acquired, and in step S12, the measurement value included in the measurement data of the evaluation target acquired in step S11 is used to determine whether the evaluation target has dementia.
  • step S12 the measurement value included in the measurement data of the evaluation target acquired in step S11 is used to determine whether the evaluation target has dementia.
  • highly reliable information can serve as a reference for knowing the risk of developing dementia in the future.
  • the subject to be evaluated has MCI, or is evaluated to be highly likely to have MCI by some means such as testing, it will be helpful in knowing the risk of developing dementia in the future.
  • Obtained highly reliable information can be provided, for example, in a stage prior to the onset of dementia called MCI, for the purpose of preventing the onset of dementia, for example.
  • the evaluation method according to the present embodiment is useful as a simple and inexpensive dementia onset risk prediction test method suitable for mass screening.
  • the evaluation results of the future risk of developing dementia obtained by the evaluation method according to the present embodiment are, for example, dementia disease-modifying drugs (e.g., anti-amyloid ⁇ antibody, anti-amyloid ⁇ protofibril antibody, anti-tau It can be used for discrimination (screening) of administration subjects of antibodies, amyloid ⁇ vaccines, etc.
  • dementia disease-modifying drugs e.g., anti-amyloid ⁇ antibody, anti-amyloid ⁇ protofibril antibody, anti-tau It can be used for discrimination (screening) of administration subjects of antibodies, amyloid ⁇ vaccines, etc.
  • the evaluation result of the future risk of developing dementia obtained by the evaluation method according to the present embodiment can be used, for example, to predict the therapeutic effect of an AD disease-modifying drug (for example, the evaluation according to the present embodiment After administering the drug to a person who has been evaluated to have a high risk of future onset by the method, the person after the administration is re-evaluated by the evaluation method according to this embodiment, and if the risk of future onset is low, treatment It may be predicted that there is a possibility that it can be said to be effective.)
  • the evaluation result of the future onset risk of dementia obtained by the evaluation method according to the present embodiment is, for example, dementia Can be used to predict progress.
  • a test step of testing the ApoE gene using a biological sample for example, blood, oral swab, or hair
  • a biological sample for example, blood, oral swab, or hair
  • determining the ApoE genotype obtained by the test a determination step of determining the value of a categorical variable related to APOE allele possession, and in step S12, the measured value (specifically the sum of the concentration values of Val, Leu, and Ile) and the determination You may evaluate the future onset risk of dementia about an evaluation object using the calculated value.
  • the values of the categorical variables include i) the value of a binary variable (dummy variable) regarding the presence or absence of the APOE ⁇ 4 allele, ii) the value of the number of APOE ⁇ 4 alleles contained in the APOE genotype (0, 1, or 2).
  • APOE genotypes based on three isoforms for the APOE gene (( ⁇ 2 allyl, ⁇ 2 allyl), ( ⁇ 3 allyl, ⁇ 3 allyl), ( ⁇ 4 allyl, ⁇ 4 allyl), ( ⁇ 2 The values assigned to each of ( ⁇ 2 allyl, ⁇ 3 allyl), ( ⁇ 2 allyl, ⁇ 4 allyl), and ( ⁇ 3 allyl, ⁇ 4 allyl)) may be used.
  • step S11 the test step and a confirmation step of confirming whether or not the subject has the APOE ⁇ 4 allele based on the ApoE genotype obtained by the test are executed, and in step S11, Measurement data is obtained using blood collected from an evaluation subject that does not possess the APOE ⁇ 4 allele, and in step S12, measurement values included in the obtained measurement data (specifically, Ala, Arg, Asn, Cit, Gln, Gly , His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, and Val concentration values and at least one of the sum of Val, Leu, and Ile concentration values) may be used to assess the future risk of developing dementia for the subject.
  • measurement values included in the obtained measurement data specifically, Ala, Arg, Asn, Cit, Gln, Gly , His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, and Val concentration values and at least one of
  • the measured value reflects the future risk of developing dementia for the evaluation subject, and the measured value is converted, for example, by the following methods, and the converted value is evaluated It may be determined to reflect the future risk of developing dementia for the subject.
  • the measured value or the converted value of the measured value itself may be treated as the evaluation result regarding the future risk of developing dementia for the evaluation target.
  • the range that the measured value can take is a predetermined range (for example, the range from 0.0 to 1.0, the range from 0.0 to 10.0, the range from 0.0 to 100.0, or from -10.0 10.0 range, etc.), for example, adding, subtracting, multiplying, or dividing the measured value by an arbitrary value, or converting the measured value to a predetermined conversion method (e.g., exponential conversion, logarithmic conversion , angle transform, square root transform, probit transform, reciprocal transform, Box-Cox transform, or exponentiation), or by performing a combination of these calculations on the measured value may be converted.
  • a predetermined conversion method e.g., exponential conversion, logarithmic conversion , angle transform, square root transform, probit transform, reciprocal transform, Box-Cox transform, or exponentiation
  • the value of the exponential function with the measured value as the index and the Napier number as the base (specifically, the probability p that the future risk of developing dementia is in a predetermined state (such as a high-risk state) is defined
  • the value of p/(1-p) when the natural logarithm ln (p/(1-p)) is equal to the measured value) may be further calculated, and the value of the calculated exponential function is set to 1 and the value (specifically, the value of the probability p) may be further calculated.
  • the measured value may be converted so that the value after conversion under a specific condition becomes a specific value.
  • the measured value may be converted so that the converted value is 5.0 when the specificity is 60% and the converted value is 8.0 when the specificity is 90%.
  • the measured values may be transformed so that the transformed value is 5.0 when the degree is 80% and the transformed value is 8.0 when the specificity is 95%.
  • a process of normalizing the distribution of the measured values and converting the measured values into deviation values so that the average is 50 and the standard deviation is 10 based on the normal distribution may be performed for each measurement object.
  • the various conversions described above may be performed by gender or by age.
  • the measured value in this specification may be the measured value itself, or may be a numerical value after converting the measured value.
  • the future risk of developing dementia may be evaluated for the evaluation target using the values after the measured values are converted, for example, by the conversion method described above.
  • position information regarding the position of a predetermined mark on a predetermined ruler that is visibly displayed on a display device such as a monitor or on a physical medium such as paper is a measured value or, if the measured value is converted, the converted value It may be determined that the generated location information reflects the future risk of developing dementia for the subject of evaluation.
  • the predetermined ruler is for evaluating the risk of future development of dementia, for example, a ruler with a scale, "the possible range of the measured value or the value after conversion, or , at least scales corresponding to the upper and lower limits of "a portion of the range" are indicated.
  • a predetermined mark corresponds to a measured value or a converted value, and is, for example, a circle mark or a star mark.
  • the measured value is lower than or below a predetermined value (mean ⁇ 1SD, 2SD, 3SD, N quantile, N percentile, or clinically significant cutoff value, etc.) or a predetermined value If it is higher than or equal to or higher than a predetermined value, the risk of developing dementia in the future may be evaluated for the evaluation target.
  • the deviation value (after normalizing the distribution of the measured values by gender for each measurement object, measure so that the average is 50 and the standard deviation is 10 based on the normal distribution. A value obtained by converting the value into a deviation value) may be used. For example, if the deviation value is less than the mean value -2SD (deviation value ⁇ 30) or if the deviation value is higher than the mean +2SD (deviation value >70), the future onset risk of dementia for the evaluation target may be evaluated.
  • the risk of future onset of dementia may be evaluated for the evaluation target by calculating the value of the formula using the formula and the measured values that include the variables into which the measured values are substituted. Specifically, by substituting measured values into the variables included in the formula for evaluating the future risk of developing dementia and calculating the value of the formula, the future risk of developing dementia is evaluated for the evaluation target. You may
  • step S12 the inspection step and the determination step are executed, and in step S12, the variable and a variable to which the value determined in the determination step is substituted, the measured value, and the determined value are used to calculate the value of the formula, thereby determining the risk of future onset of dementia for the evaluation subject. may be evaluated.
  • step S11 measurement data is obtained using blood collected from an evaluation subject that does not possess the APOE ⁇ 4 allele
  • step S12 Measurement values included in the acquired measurement data (specifically, Ala, Arg, Asn, Cit, Gln, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr , and at least one of the concentration values of Val and the sum of the concentration values of Val, Leu, and Ile) may be used to evaluate the risk of developing dementia in the future for the subject.
  • the value of the calculated formula reflects the future risk of developing dementia for the evaluation subject, and the value of the formula is converted, for example, by the following methods, and after conversion It may be determined that the value of reflects the future risk of developing dementia for the subject being evaluated. In other words, the value of the formula or the converted value of the formula itself may be treated as the evaluation result regarding the future risk of developing dementia for the subject of evaluation.
  • the range of possible values of the expression is a predetermined range (for example, the range from 0.0 to 1.0, the range from 0.0 to 10.0, the range from 0.0 to 100.0, or -10.0 to 10.0, etc.), for example, adding, subtracting, multiplying, or dividing the value of the expression by an arbitrary value, or converting the value of the expression to a predetermined conversion method (e.g., exponential conversion , logarithmic transformation, angle transformation, square root transformation, probit transformation, inverse transformation, Box-Cox transformation, or power transformation), or by combining these calculations on the value of the expression , may transform the value of the expression.
  • a predetermined conversion method e.g., exponential conversion , logarithmic transformation, angle transformation, square root transformation, probit transformation, inverse transformation, Box-Cox transformation, or power transformation
  • the value of the exponential function with the value of the formula as the index and the Napier number as the base (specifically, the probability p that the future risk of developing dementia is in a predetermined state (such as a high-risk state) was defined
  • the value of p / (1-p) when the natural logarithm ln (p / (1-p)) is equal to the value of the formula) may be further calculated, and the calculated value of the exponential function may be further calculated by dividing by the sum of 1 and the value (specifically, the value of probability p).
  • the value of the expression may be converted so that the value after conversion under a specific condition becomes a specific value.
  • the value of the formula may be converted so that the converted value is 5.0 when the specificity is 60% and the converted value is 8.0 when the specificity is 90%
  • the value of the formula may be transformed so that the transformed value is 5.0 when the specificity is 80% and the transformed value is 8.0 when the specificity is 95%.
  • the values in the formula may be converted into deviation values so that the average is 50 and the standard deviation is 10.
  • the various conversions described above may be performed by gender or by age.
  • the value of the formula in this specification may be the value of the formula itself, or may be the value after converting the value of the formula.
  • the position information regarding the position of a predetermined mark on a predetermined ruler visibly displayed on a display device such as a monitor or on a physical medium such as paper is the value of the formula or, if the value of the formula is converted, the conversion It may be generated using the later values and determined that the generated location information reflects the future risk of developing dementia for the subject.
  • the predetermined ruler is for evaluating the risk of developing dementia in the future. Alternatively, at least scales corresponding to the upper and lower limits of "part of the range" are indicated.
  • the predetermined mark corresponds to the value of the formula or the value after conversion, and is, for example, a circle mark or an asterisk.
  • the degree of risk (possibility) for the subject to develop dementia in the future may be qualitatively evaluated. Specifically, using "measured value and one or more preset thresholds" or “measured value, an expression containing a variable into which the measured value is substituted, and one or more preset thresholds" Therefore, the subject of evaluation may be classified into any one of a plurality of categories defined by at least considering the degree of risk of developing dementia in the future.
  • the multiple categories include a category for assigning subjects with a high risk of developing dementia in the future, a category for assigning subjects with a low risk of developing dementia in the future, and a category for assigning subjects with a low risk of developing dementia in the future.
  • a segment may be included to attribute subjects with moderate .
  • the plurality of categories may include a category for assigning subjects with a high risk of developing dementia in the future and a category for assigning subjects with a low risk of developing dementia in the future.
  • the measured value or the value of the formula may be converted by a predetermined method, and the converted value may be used to classify the evaluation object into one of a plurality of categories.
  • the formula used for evaluation is not particularly limited in form, but may be of the form shown below, for example.
  • ⁇ Linear models such as multiple regression equations, linear discriminants, principal component analysis, and canonical discriminant analysis based on the least squares method
  • Generalized linear models such as logistic regression and Cox regression based on the maximum likelihood method
  • Formulas created by cluster analysis such as K-means method and hierarchical cluster analysis ⁇ MCMC (Markov chain Monte Carlo method), Bayesian network, Formulas created based on Bayesian statistics such as hierarchical Bayesian formulas
  • Formulas created by class classification such as support vector machines and decision trees
  • Formulas created by methods that do not belong to the above categories such as fractional formulas Sum of formulas in different formats
  • An expression such as
  • the formula used in the evaluation may be, for example, the method described in International Publication No. WO 2004/052191 by the applicant or the method described in International Publication No. WO 2006/098192 by the applicant. method can be created. It should be noted that the formulas obtained by these methods can be suitably used for evaluating the future risk of developing dementia regardless of the units of the measured values.
  • coefficients and constant terms are added to each variable, and these coefficients and constant terms are preferably real numbers, more preferably is any value that belongs to the range of the 99% confidence interval of the coefficient and constant term obtained for performing the various classifications from the data, and more preferably, the value obtained for performing the various classifications from the data Any value within the 95% confidence interval of the coefficient and the constant term will do.
  • the value of each coefficient and its confidence interval may be obtained by multiplying it by a real number
  • the value of the constant term and its confidence interval may be obtained by adding, subtracting, multiplying, or dividing it by an arbitrary real constant.
  • linear transformation addition of constant, constant multiplication
  • monotonically increasing (decreasing) transformation e.g. logit transformation
  • a fractional expression is such that the numerator of the fractional expression is represented by the sum of variables A, B, C, . is represented by the sum of Fractional expressions also include the sum of fractional expressions ⁇ , ⁇ , ⁇ , . Fractional expressions also include divided fractional expressions. It should be noted that the variables used for the numerator and denominator may each have appropriate coefficients. Also, the variables used for the numerator and denominator may overlap. Also, each fractional expression may have an appropriate coefficient. Also, the coefficient values and constant term values of each variable may be real numbers.
  • fractional formula includes the fractional formula after the replacement.
  • values related to other biological information listed below may be further used.
  • the formula used for evaluation may further include one or more variables into which values related to other biometric information listed below are substituted, in addition to variables into which measured values are substituted.
  • biomarkers such as information (walking speed, grip strength, etc.); Values obtained from genetic information in biological samples (eg, blood, oral swabs, hair, etc.), such as the number of carriers of Alzheimer's disease risk genes (APOE ⁇ 4 allele, etc.)6.
  • MMSE Mini-Mental State Examination
  • MoCA Monitoring Cognitive Assessment
  • FAB Fluorescence Antibody
  • HDS-R Revised Hasegawa Simple Intelligence Scale
  • WAIS TM Wechsler Adult Intelligence Scale
  • WMS TM -R Wechsler memory test revised edition
  • CDR clinical dementia scale
  • ADAMS-Cog Alzheimer's Disease Assessment Scale-cognitive subscale
  • GDS Garitaric Depression Scale (geriatric depression scale)
  • FIG. 2 is a principle configuration diagram showing the basic principle of the second embodiment.
  • the description that overlaps with the above-described first embodiment may be omitted.
  • the case of using the value of the formula or its converted value is described as an example, but for example, the measured value or its converted value ( For example, a deviation value, etc.) may be used.
  • the control unit calculates the value of the expression using the expression stored in the storage unit in advance, which includes the measured values included in the measurement data to be evaluated and the variables into which the measured values are substituted.
  • a subject is evaluated for future risk of developing dementia (step S21).
  • step S21 may be created based on the formula creation process (steps 1 to 4) described below.
  • steps 1 to 4 an outline of the formula creating process will be described. It should be noted that the processing described here is merely an example, and the method of creating an expression is not limited to this.
  • the index state information includes measurement data and index data (for example, binary data) regarding the risk of developing dementia in the future.
  • a plurality of different formula creation methods may be used together to create a plurality of candidate formulas.
  • index status information which is multivariate data composed of measurement data and index data obtained by analyzing blood obtained from a large number of people without dementia (for example, healthy subjects or patients with MCI)
  • a plurality of groups of candidate formulas may be generated concurrently using a plurality of different algorithms.
  • discriminant analysis and logistic regression analysis may be performed simultaneously using different algorithms to generate two different candidate formulas.
  • a candidate formula may be generated by converting the index state information using a candidate formula created by performing principal component analysis and performing discriminant analysis on the converted index state information.
  • the candidate formula created using principal component analysis is a linear formula containing each variable that maximizes the variance of all measured data.
  • Candidate formulas created using discriminant analysis are high-order formulas (including exponentials and logarithms) that contain variables that minimize the ratio of the sum of variances within each group to the variance of all measured data. be.
  • the candidate formulas created using the support vector machine are high-order formulas (including kernel functions) containing each variable that maximizes the boundary between groups.
  • a candidate formula created using multiple regression analysis is a high-order formula including each variable that minimizes the sum of distances from all measured data.
  • a candidate formula created using Cox regression analysis is a linear model including a logarithmic hazard ratio, and is a linear formula including each variable and its coefficient that maximizes the likelihood of the model.
  • a candidate formula created using logistic regression analysis is a linear model representing the logarithmic odds of probability, and is a linear formula containing each variable that maximizes the likelihood of that probability.
  • k neighbors of each measurement data are searched, and the group to which the input measurement data belongs is defined as the group to which the largest number of neighboring points belong. This is a method of selecting variables that best match the group defined as .
  • Cluster analysis is a method of clustering (grouping) points that are closest to each other in all measurement data.
  • a decision tree is a technique for assigning an order to variables and discriminating a group of measurement data from patterns that variables with higher order can take.
  • the control unit verifies (cross-verifies) the candidate formulas created in step 1 based on a predetermined verification method (step 2). Verification of the candidate formula is performed for each candidate formula created in step 1.
  • step 2 based on at least one of a plurality of methods such as the bootstrap method, holdout method, N-fold method, and leave-one-out method, the discrimination rate, sensitivity, and specificity of the candidate formula , Information Criterion (Akaike Information Criterion (AIC), Bayesian Information Criterion (BIC)), ROC_AUC (area under the receiver characteristic curve), C-index (Concordance index), etc. Verification may be performed with respect to one type of index. As a result, it is possible to create candidate formulas with high predictability or robustness that take into account index state information and evaluation conditions.
  • AIC Kaike Information Criterion
  • BIC Bayesian Information Criterion
  • ROC_AUC area under the receiver characteristic curve
  • C-index Conscordance index
  • the discrimination rate is the evaluation method according to the present embodiment, and an evaluation subject whose true state is negative (e.g., an evaluation subject that did not develop dementia after a certain period of time from blood collection) is correctly evaluated as negative.
  • it is the ratio of correct positive evaluation subjects whose true status is positive (for example, evaluation subjects who developed dementia after a certain period of time from blood sampling).
  • the sensitivity is the ratio of correct positive evaluations of evaluation targets whose true state is positive in the evaluation method according to the present embodiment.
  • the specificity is the proportion of the evaluation targets whose true status is negative are correctly evaluated as negative in the evaluation method according to the present embodiment.
  • the Akaike Information Criterion is a criterion that indicates how well observed data matches a statistical model in the case of regression analysis, etc. x (the number of free parameters of the statistical model)” is judged to be the best model.
  • the Bayesian Information Criterion is a model selection criterion derived based on the concept of Bayesian statistics, "-2 ⁇ (maximum logarithmic likelihood of statistical model) + (number of free parameters of statistical model) x ln (sample size)” (model with few parameters) is determined to be the best.
  • C-index is an index representing the accuracy of prognosis prediction proposed by Harrell et al. is a good indicator.
  • the predictability is the average of discrimination rate, sensitivity, and specificity obtained by repeating verification of candidate formulas.
  • Robustness is variance of discrimination rate, sensitivity, and specificity obtained by repeating verification of candidate formulas.
  • the control unit selects a combination of measurement data included in the index state information used when creating the candidate formula by selecting variables of the candidate formula based on a predetermined variable selection method.
  • variables may be selected for each candidate formula created in step 1. This allows appropriate selection of the variables of the candidate formula.
  • step 1 is executed again.
  • variables of the candidate formula are selected based on at least one of the stepwise method, best path method, neighborhood search method, and genetic algorithm. good too.
  • the best path method is a method of selecting variables by sequentially reducing the variables included in the candidate formula one by one and optimizing the evaluation index given by the candidate formula.
  • control unit repeatedly executes the above-described steps 1, 2, and 3, and based on the verification results accumulated by this, selects a candidate formula from among a plurality of candidate formulas to be used for evaluation.
  • a formula to be used for evaluation is created (step 4).
  • Selection of candidate formulas includes, for example, selecting the optimum candidate formula from among candidate formulas prepared by the same formula preparation method, and selecting the optimum formula from all candidate formulas.
  • the creation of the candidate formula, the verification of the candidate formula, and the selection of the variables of the candidate formula are systematized and executed in a series of steps, thereby improving the dementia.
  • the optimal formula for assessing the risk of future onset of
  • the measured values are used for multivariate statistical analysis, and by combining the variable selection method and cross-validation to select the optimal and robust set of variables, a formula with high evaluation performance to extract
  • this system the configuration of the evaluation system (hereinafter sometimes referred to as "this system") according to the second embodiment will be described with reference to FIGS. 3 to 8.
  • FIG. Note that this system is merely an example, and the present invention is not limited to this.
  • the case of using the value of the formula or its converted value is described as an example, but for example, the measured value or its converted value ( For example, a deviation value, etc.) may be used.
  • FIG. 3 is a diagram showing an example of the overall configuration of this system.
  • FIG. 4 is a diagram showing another example of the overall configuration of this system.
  • this system comprises an evaluation device 100 that evaluates the risk of developing dementia in the future for an individual to be evaluated, and a client device 200 that provides measurement data of the individual (corresponding to the terminal device of the present invention). ) are communicably connected via the network 300 .
  • the client device 200 that provides the data used for evaluation and the client device 200 that provides the evaluation results may be separate devices.
  • the present system includes a database device 400 that stores index state information used to create formulas in the evaluation device 100, formulas used in evaluation, and the like. may be configured to be communicably connected via the network 300 .
  • FIG. 5 is a block diagram showing an example of the configuration of the evaluation device 100 of this system, and conceptually shows only those portions of the configuration that are related to the present invention.
  • the evaluation device 100 controls the evaluation device through a control unit 102 such as a CPU (Central Processing Unit) that controls the evaluation device, a communication device such as a router, and a wired or wireless communication line such as a dedicated line. It is composed of a communication interface unit 104 communicatively connected to the network 300, a storage unit 106 storing various databases, tables, files, etc., and an input/output interface unit 108 connected to the input device 112 and the output device 114. , and these units are communicably connected via an arbitrary communication path.
  • the evaluation device 100 may be configured in the same housing as various analysis devices (for example, an analysis device that analyzes a measurement target, etc.).
  • a small analyzer having a configuration (hardware and software) for calculating measured values and outputting (printing, monitor display, etc.) the calculated measured values further includes an evaluation unit 102d described later, and the evaluation unit 102d and outputting the result obtained by using the above configuration.
  • the communication interface unit 104 mediates communication between the evaluation device 100 and the network 300 (or a communication device such as a router). That is, the communication interface unit 104 has a function of communicating data with another terminal via a communication line.
  • the input/output interface unit 108 connects to the input device 112 and the output device 114 .
  • the output device 114 may be a monitor (including a home television), a speaker, or a printer (below, the output device 114 may be referred to as the monitor 114).
  • the input device 112 can be a keyboard, a mouse, a microphone, or a monitor that realizes a pointing device function in cooperation with a mouse.
  • the storage unit 106 is storage means, and can use, for example, a memory device such as RAM (Random Access Memory) or ROM (Read Only Memory), a fixed disk device such as a hard disk, a flexible disk, an optical disk, or the like.
  • the storage unit 106 stores a computer program that cooperates with the OS (Operating System) to issue commands to the CPU to perform various processes. As illustrated, the storage unit 106 stores a measurement data file 106a, an index state information file 106b, a designated index state information file 106c, a formula related information database 106d, and an evaluation result file 106e.
  • the measurement data file 106a stores measurement data.
  • FIG. 6 is a diagram showing an example of information stored in the measurement data file 106a.
  • the information stored in the measurement data file 106a is configured by associating an individual number for uniquely identifying an individual (sample) to be evaluated with the measurement data.
  • the measured data are treated as numerical values, that is, as a continuous scale, but the measured data may be a nominal scale or an ordinal scale. If the measurement data is a nominal scale or an ordinal scale, arbitrary numerical values given to each state may be used for various processes such as evaluation and calculation of formula values. Also, the measured data may be combined with other biometric information values (see above).
  • the index state information file 106b stores index state information used when formulating formulas.
  • FIG. 7 is a diagram showing an example of information stored in the index state information file 106b.
  • the information stored in the index status information file 106b is configured by correlating individual numbers, index data regarding the risk of developing AD in the future, and measurement data.
  • index data and measurement data are treated as numerical values, that is, continuous scales, but index data and measurement data may be nominal scales or ordinal scales.
  • index data and measurement data are nominal scales or ordinal scales, arbitrary numerical values given to each state may be used for various processes such as evaluation and calculation of formula values.
  • the designated index state information file 106c stores the index state information designated by the later-described designation section 102b.
  • FIG. 8 is a diagram showing an example of information stored in the specified index state information file 106c. As shown in FIG. 8, the information stored in the designated index state information file 106c is configured by associating individual numbers, designated index data, and designated measurement data.
  • the formula-related information database 106d is composed of formula files 106d1 that store formulas created by the formula creating unit 102c, which will be described later.
  • the formula file 106d1 stores formulas used for evaluation.
  • FIG. 9 is a diagram showing an example of information stored in the formula file 106d1.
  • Information stored in the formula file 106d1 includes ranks, formulas (in FIG. 9, Fp(His, . . . ), Fp(His, 3h-Kyn, Kyn), Fk(His, 3h-Kyn, Kyn, .
  • FIG. 10 is a diagram showing an example of information stored in the evaluation result file 106e.
  • the information stored in the evaluation result file 106e includes an individual number for uniquely identifying the individual (sample) to be evaluated, measurement data of the individual obtained in advance, and an evaluation result regarding the risk of developing dementia in the future ( For example, a value of a formula calculated by a calculation unit 102d1, which will be described later, a value after converting the value of a formula by a conversion unit 102d2, which will be described later, position information generated by a generation unit 102d3, which will be described later, or obtained by a classification unit 102d4, which will be described later. classification results, etc.) and are associated with each other.
  • control unit 102 has an internal memory for storing a control program such as an OS, a program defining various processing procedures, required data, and the like, and performs various information processing based on these programs. to run. As illustrated, the control unit 102 is roughly divided into an acquisition unit 102a, a designation unit 102b, an expression creation unit 102c, an evaluation unit 102d, a result output unit 102e, and a transmission unit 102f.
  • the control unit 102 removes data with missing values, removes data with many outliers, and removes data with missing values from the index state information sent from the database device 400 and the measurement data sent from the client device 200. We also perform data processing such as removing variables with a large number of
  • the acquisition unit 102a acquires information (specifically, measurement data, index state information, formulas, etc.). For example, the acquisition unit 102a receives information (specifically, measurement data, index state information, formulas, etc.) transmitted from the client device 200 or the database device 400 via the network 300 or the like. Acquisition may be performed. Note that the acquisition unit 102a may receive data used for evaluation transmitted from a client device 200 different from the client device 200 to which the evaluation result is transmitted. Further, for example, when the evaluation device 100 includes a mechanism (including hardware and software) for reading information recorded on the recording medium, the acquisition unit 102a reads the information recorded on the recording medium (specifically, Specifically, information may be obtained by reading measurement data, index state information, formulas, etc.) via the mechanism. The designating unit 102b designates target index data and measurement data when creating a formula.
  • the formula creation unit 102c creates a formula based on the index state information acquired by the acquisition unit 102a and the index state information specified by the specification unit 102b. Note that, when formulas are stored in advance in a predetermined storage area of the storage unit 106, the formula creation unit 102c may create a formula by selecting a desired formula from the storage unit 106. FIG. Alternatively, the formula creation unit 102c may create a formula by selecting and downloading a desired formula from another computer device (for example, the database device 400) in which formulas are stored in advance.
  • another computer device for example, the database device 400
  • the evaluation unit 102d uses a formula obtained in advance (for example, a formula created by the formula creation unit 102c or a formula acquired by the acquisition unit 102a) and measurement values included in the individual measurement data acquired by the acquisition unit 102a. Calculating the value of the formula assesses the individual's risk of future development of dementia. Note that the evaluation unit 102d may use the measured value or its converted value (for example, deviation value) to evaluate the future risk of developing dementia for the individual.
  • FIG. 11 is a block diagram showing the structure of the evaluation unit 102d, and conceptually shows only the part of the structure related to the present invention.
  • the evaluation unit 102d further includes a calculation unit 102d1, a conversion unit 102d2, a generation unit 102d3, and a classification unit 102d4.
  • the calculation unit 102d1 calculates the value of the formula using the formula including variables into which the measured values are substituted and the measured values included in the measured data. Note that the evaluation unit 102d may store the value of the formula calculated by the calculation unit 102d1 as the evaluation result in a predetermined storage area of the evaluation result file 106e.
  • the conversion unit 102d2 converts the value of the formula calculated by the calculation unit 102d1, for example, using the conversion method described above.
  • the evaluation unit 102d may store the value converted by the conversion unit 102d2 as the evaluation result in a predetermined storage area of the evaluation result file 106e. Further, the conversion unit 102d2 may convert the measured value included in the measurement data, for example, using the conversion method described above.
  • Generating unit 102d3 converts position information about the position of a predetermined mark on a predetermined ruler visibly displayed on a display device such as a monitor or on a physical medium such as paper into the value of the formula calculated by calculating unit 102d1 or the converting unit 102d2. It is generated using the value after conversion by (it may be the measured value or the value after conversion).
  • the evaluation unit 102d may store the position information generated by the generation unit 102d3 as the evaluation result in a predetermined storage area of the evaluation result file 106e.
  • the classification unit 102d4 uses the value of the formula calculated by the calculation unit 102d1 or the value after conversion by the conversion unit 102d2 (measured value or the converted value may be used) to classify the individual at the future onset risk of dementia. into any one of a plurality of categories defined taking into account at least the .
  • the result output unit 102e outputs to the output device 114 the processing results of each processing unit of the control unit 102 (including the evaluation results obtained by the evaluation unit 102d).
  • the transmission unit 102f transmits evaluation results to the client device 200 that is the transmission source of the individual measurement data, and transmits formulas created by the evaluation device 100 and evaluation results to the database device 400. Note that the transmission unit 102f may transmit the evaluation result to a client device 200 different from the client device 200 that is the transmission source of the data used for evaluation.
  • FIG. 12 is a block diagram showing an example of the configuration of the client device 200 of this system, and conceptually shows only those portions of the configuration that are related to the present invention.
  • the client device 200 is composed of a control unit 210, a ROM 220, a HD (Hard Disk) 230, a RAM 240, an input device 250, an output device 260, an input/output IF 270, and a communication IF 280. are connected so that they can communicate with each other.
  • the client device 200 is an information processing device (for example, a personal computer, a workstation, a home game device, an Internet TV, a PHS (Personal Handyphone System) terminal, etc.) to which peripheral devices such as a printer, monitor, and image scanner are connected as necessary.
  • Known information processing terminals such as portable terminals, mobile communication terminals, PDA (Personal Digital Assistant), etc. may also be used.
  • the input device 250 is a keyboard, mouse, microphone, or the like.
  • a monitor 261 which will be described later, also cooperates with the mouse to realize the pointing device function.
  • Output device 260 is output means for outputting information received via communication IF 280 , and includes monitor (including home television) 261 and printer 262 .
  • the output device 260 may be provided with a speaker or the like.
  • the input/output IF 270 connects to the input device 250 and the output device 260 .
  • the communication IF 280 communicably connects the client device 200 and the network 300 (or a communication device such as a router).
  • the client device 200 is connected to the network 300 via a communication device (eg, modem, TA (Terminal Adapter), router, etc.) and a telephone line or a dedicated line.
  • a communication device eg, modem, TA (Terminal Adapter), router, etc.
  • the client device 200 can access the evaluation device 100 according to a predetermined communication protocol.
  • the control unit 210 includes a receiving unit 211 and a transmitting unit 212.
  • the receiving unit 211 receives various information such as evaluation results transmitted from the evaluation device 100 via the communication IF 280 .
  • the transmission unit 212 transmits various types of information such as individual measurement data to the evaluation device 100 via the communication IF 280 .
  • the control unit 210 may realize all or any part of the processing performed by the control unit by a CPU and a program interpreted and executed by the CPU.
  • the ROM 220 or HD 230 stores a computer program for giving instructions to the CPU in cooperation with the OS and performing various processes.
  • the computer program is executed by being loaded into the RAM 240 and configures the control unit 210 in cooperation with the CPU.
  • the computer program may be recorded in an application program server connected to the client device 200 via any network, and the client device 200 may download all or part of it as necessary.
  • all or any part of the processing performed by the control unit 210 may be realized by hardware such as wired logic.
  • control unit 210 includes an evaluation unit 210a (including a calculation unit 210a1, a conversion unit 210a2, a generation unit 210a3, and a classification unit 210a4) having the same function as the evaluation unit 102d provided in the evaluation apparatus 100. ).
  • the evaluation unit 210a causes the conversion unit 210a2 to convert the expression value (
  • the generation unit 210a3 generates position information corresponding to the value of the formula or the value after conversion (which may be the measured value or the value after conversion), and the classification unit 210a4 generates the position information corresponding to the value of the formula.
  • a value or a transformed value (measured value or transformed value may be used) may be used to classify an individual into one of a plurality of categories.
  • the network 300 has a function of connecting the evaluation device 100, the client device 200, and the database device 400 so that they can communicate with each other.
  • the network 300 includes a VAN (Value-Added Network), a personal computer communication network, a public telephone network (including both analog and digital), a leased line network (including both analog and digital), CATV ( Community Antenna TeleVision) network, mobile circuit switched network or mobile packet switched network (IMT (International Mobile Telecommunication) 2000 system, GSM (registered trademark) (Global System for Mobile Communications) system, or PDC (Personal Digital Cellular) / PDC- P system, etc.), radio call network, local wireless network (including Bluetooth (registered trademark), etc.), PHS network, satellite communication network (CS (Communication Satellite), BS (Broadcasting Satellite), or ISDB (including Integrated Services Digital Broadcasting), etc.).
  • VAN Value-Added Network
  • a personal computer communication network including both analog and digital
  • a public telephone network including both analog and digital
  • FIG. 13 is a block diagram showing an example of the configuration of the database device 400 of this system, and conceptually shows only those portions of the configuration related to the present invention.
  • the database device 400 has a function of storing index state information used when formulas are created by the evaluation device 100 or the database device, formulas created by the evaluation device 100, evaluation results by the evaluation device 100, and the like.
  • the database device 400 includes a control unit 402 such as a CPU that controls the database device, a communication device (router, etc.), and a wired or wireless communication circuit (dedicated line, etc.). It is connected to a communication interface unit 404 that communicably connects the database device to the network 300, a storage unit 406 that stores various databases, tables, files (for example, files for web pages), an input device 412, and an output device 414. and an input/output interface unit 408, and these units are communicably connected via an arbitrary communication path.
  • a control unit 402 such as a CPU that controls the database device, a communication device (router, etc.), and a wired or wireless communication circuit (dedicated line, etc.). It is connected to a communication interface unit 404 that communicably connect
  • the storage unit 406 is storage means, and can use, for example, a memory device such as RAM/ROM, a fixed disk device such as a hard disk, a flexible disk, an optical disk, or the like.
  • the storage unit 406 stores various programs and the like used for various processes.
  • the communication interface unit 404 mediates communication between the database device 400 and the network 300 (or a communication device such as a router). That is, the communication interface unit 404 has a function of communicating data with another terminal via a communication line.
  • the input/output interface unit 408 connects to the input device 412 and the output device 414 .
  • the output device 414 can be a monitor (including a home television), a speaker, or a printer.
  • the input device 412 can be a keyboard, a mouse, a microphone, or a monitor that realizes a pointing device function in cooperation with a mouse.
  • the control unit 402 has an internal memory for storing control programs such as an OS, programs defining various processing procedures, required data, and the like, and executes various information processing based on these programs. As illustrated, the control unit 402 is roughly divided into a transmission unit 402a and a reception unit 402b.
  • the transmitting unit 402a transmits various types of information such as index state information and formulas to the evaluation apparatus 100.
  • FIG. The receiving unit 402b receives various information such as formulas and evaluation results transmitted from the evaluation apparatus 100 .
  • the evaluation device 100 receives the measurement data, calculates the value of the formula, classifies the individuals into categories, and transmits the evaluation results, and the client device 200 receives the evaluation results.
  • the client device 200 is provided with the evaluation unit 210a, it is sufficient for the evaluation device 100 to calculate the value of the expression.
  • classification of individuals into categories, and the like may be appropriately shared between the evaluation device 100 and the client device 200 .
  • the evaluation unit 210a converts the value of the expression with the conversion unit 210a2, and the value of the expression or the converted value with the generation unit 210a3.
  • the classification unit 210a4 may classify the individual into any one of a plurality of classes using the value of the formula or the converted value thereof.
  • the evaluation unit 210a causes the generation unit 210a3 to generate location information corresponding to the converted value, or the classification unit 210a4 to generate location information corresponding to the converted value.
  • Individuals may be classified into any one of a plurality of categories using the value of .
  • the evaluation unit 210a classifies the value of the formula or its converted value in the classification unit 210a4. may be used to classify an individual into any one of a plurality of categories.
  • the evaluation device, the calculation device, the evaluation method, the calculation method, the evaluation program, the calculation program, the evaluation system, and the terminal device according to the present invention are not limited to the above-described second embodiment. Various different embodiments may be implemented within the scope.
  • processing procedures, control procedures, specific names, information including parameters such as registration data and search conditions for each process, screen examples, and database configurations shown in this specification and drawings may not be specified unless otherwise specified. can be changed arbitrarily except for
  • each component shown in the figure is functionally conceptual, and does not necessarily need to be physically configured as shown in the figure.
  • the processing functions provided by the evaluation device 100 may be implemented in whole or in part by a CPU and a program interpreted and executed by the CPU. Alternatively, it may be implemented as hardware by wired logic.
  • the program is recorded on a non-temporary computer-readable recording medium containing programmed instructions for causing the information processing apparatus to execute the evaluation method according to the present invention. read mechanically. That is, the storage unit 106 such as ROM or HDD stores computer programs for giving commands to the CPU in cooperation with the OS to perform various processes. This computer program is executed by being loaded into the RAM and constitutes a control section in cooperation with the CPU.
  • this computer program may be stored in an application program server connected to the evaluation apparatus 100 via any network, and it is possible to download all or part of it as necessary. .
  • the evaluation program according to the present invention may be stored in a non-temporary computer-readable recording medium, or may be configured as a program product.
  • this "recording medium” includes memory cards, USB memories, SD cards, flexible disks, magneto-optical disks, ROMs, EPROMs, EEPROMs (registered trademark), CD-ROMs, MOs, DVDs, and Blu-ray ( (registered trademark) include any "portable physical media” such as Discs.
  • a "program” is a data processing method written in any language or writing method, regardless of the format such as source code or binary code.
  • the "program” is not necessarily limited to a single configuration, but is distributed as multiple modules or libraries, or cooperates with a separate program represented by the OS to achieve its function. Including things. It should be noted that well-known configurations and procedures can be used for the specific configuration and reading procedure for reading the recording medium in each device shown in the embodiments, the installation procedure after reading, and the like.
  • the various databases stored in the storage unit are storage means such as memory devices such as RAM and ROM, fixed disk devices such as hard disks, flexible disks, and optical disks. Stores programs, tables, databases, files for web pages, and so on.
  • the evaluation device 100 may be configured as an information processing device such as a known personal computer or workstation, or an information processing device to which any peripheral device is connected. Moreover, the evaluation device 100 may be realized by installing software (including programs, data, etc.) for realizing the evaluation method of the present invention in the information processing device.
  • the specific form of distributing/integrating the devices is not limited to the illustrated one, and all or part of the devices can be functionally or physically distributed/integrated in arbitrary units according to various additions or functional loads.
  • Example 1 The sample data obtained in Example 1 was used.
  • a logistic regression formula was used as the multivariate discriminant.
  • a combination of two variables to be included in the logistic regression formula was searched from the plasma concentration values of the 19 kinds of amino acids, and a search for a logistic regression formula with good ability to discriminate between the AD non-onset group and the AD onset group was performed.
  • the list of 121 logistic regression formulas (the number of variables included in the formula is 2) that had a ROC_AUC value of 0.600 or more in discriminating between the AD non-onset group and the AD onset group is shown below in [1.
  • a two-variable formula including amino acids Since the ROC_AUC values corresponding to these 121 logistic regression equations are high, it is believed that these 121 logistic regression equations are useful for the evaluation described in Example 1. Note that the following [1. Two-variable formula including amino acids] shows the variables included in the formula and the ROC_AUC value for each formula (the same applies hereinafter).
  • Example 1 The sample data used in Example 1 was used.
  • a logistic regression formula was used as the multivariate discriminant.
  • a combination of three variables to be included in the logistic regression formula was searched from the plasma concentration values of the 19 amino acids, and a search for a logistic regression formula with good ability to discriminate between the AD non-development group and the AD development group was performed.
  • Example 1 The sample data used in Example 1 was used.
  • a logistic regression formula was used as the multivariate discriminant. Combinations of four variables to be included in the logistic regression equation were searched from the plasma concentration values of the 19 amino acids, and a search for a logistic regression equation with good ability to discriminate between the AD non-onset group and the AD onset group was performed.
  • Example 1 The sample data used in Example 1 was used.
  • a logistic regression formula was used as the multivariate discriminant. Combinations of five variables to be included in the logistic regression equation were searched from the plasma concentration values of the 19 kinds of amino acids, and a search for a logistic regression equation with good ability to discriminate between the AD non-onset group and the AD onset group was performed.
  • Example 1 The sample data obtained in Example 1 was used.
  • a logistic regression formula was used as the multivariate discriminant.
  • a combination of six variables to be included in the logistic regression formula was searched from the plasma concentration values of the 19 amino acids, and a search for a logistic regression formula with good ability to discriminate between the AD non-onset group and the AD onset group was performed.
  • Example 1 The blood samples and dementia diagnosis results obtained in Example 1 and the blood concentrations (nmol/ml) of the 19 amino acids measured in Example 1 were used (total of 88 cases). As described in Example 1, these 88 cases were classified into an AD onset group (23 cases) and an AD non-onset group (65 cases).
  • a whole blood sample is obtained from the blood sample, the white blood cell count (/ ⁇ L) in the whole blood is determined by flow cytometry using a semiconductor laser, and the red blood cell count ( ⁇ 10 4 / ⁇ L) in the whole blood is determined by the sheath flow direct current detection method.
  • the hemoglobin amount (g/dL) in whole blood was measured by the SLS-hemoglobin method, and the hematocrit value (%) in whole blood was measured by the erythrocyte pulse peak value detection method.
  • a serum sample was obtained from the blood sample, and the folic acid concentration (ng/mL) in the serum was measured by the chemiluminescent enzyme immunoassay method, the LDL-cholesterol concentration (mg/dL) in the serum was measured by the direct method, and the improved BCP method was used.
  • Serum albumin concentration (g/dL) by immunonephelometry, serum prealbumin concentration (mg/dL) by immunoturbidimetry, serum C-reactive protein concentration (mg/dL) by latex immunoturbidimetry were measured for triglyceride concentration (mg/dL) in serum by the enzymatic method and uric acid concentration (mg/dL) in serum by the uricase POD method.
  • a discriminant multivariate function
  • a logistic regression equation was used as the multivariate discriminant. For combinations of four variables to be included in the logistic regression equation, three plasma concentration values are selected from the above-described 19 amino acid plasma concentration values, and one test value or characteristic value is selected from Group 1 below. Under these conditions, a search was made for a logistic regression formula with good ability to discriminate between the AD non-onset group and the AD onset group.
  • Group 1 body weight (kg), BMI (kg/m 2 ), white blood cell count in whole blood (WBC), red blood cell count in whole blood (RBC), hemoglobin content in whole blood (Hb), total Blood hematocrit value (Ht), serum folic acid concentration (folic acid), serum LDL-cholesterol concentration (LDLC), serum albumin concentration (Alb), serum prealbumin concentration (prealbumin), serum It consists of C-reactive protein concentration (CRP) in serum, triglyceride concentration (TG), and concentration of uric acid in serum (uric acid).
  • WBC white blood cell count in whole blood
  • RBC red blood cell count in whole blood
  • Hb hemoglobin content in whole blood
  • Ht total Blood hematocrit value
  • serum folic acid concentration folic acid
  • LDLC serum LDL-cholesterol concentration
  • Alb serum albumin concentration
  • prealbumin concentration prealbumin
  • serum It consists of C-reactive protein concentration (CRP) in serum, triglycer
  • Table 4 shows the number and percentage of formulas in which the ROC_AUC value in discriminating between the AD non-onset group and the AD onset group increased by incorporating variables other than the 19 types of amino acids.
  • Blood samples and dementia diagnosis results obtained in Example 1 blood concentrations (nmol/ml) of the 19 amino acids measured in Example 1, and 11 test items measured in Example 7 and two types of physical feature values were used (total of 88 cases). As described in Example 1, these 88 cases were classified into an AD onset group (23 cases) and an AD non-onset group (65 cases).
  • a serum sample was obtained from the blood sample, and the ⁇ GTP concentration (U/L) in serum was measured according to the JSCC standardized method.
  • a method for discriminating two groups, an AD non-onset group and an AD onset group including a variable to which a plasma amino acid concentration value is substituted and a variable to which a test value of a general biochemical index or a characteristic value of a physical characteristic is substituted.
  • a multivariate discriminant multivariate function
  • a logistic regression formula was used as the multivariate discriminant. For combinations of five variables to be included in the logistic regression equation, four plasma concentration values are selected from the plasma concentration values of the above 19 amino acids, and one test value or characteristic value is selected from Group 2 below. Under these conditions, a search for a logistic regression formula with a good ability to discriminate between the AD non-onset group and the AD onset group was performed. Group 2 is a group obtained by adding serum ⁇ GTP concentration ( ⁇ GTP) to Group 1 described in Example 7.
  • Table 5 shows the number and percentage of formulas in which the ROC_AUC value in discriminating between the AD non-onset group and the AD onset group increased by incorporating variables other than the 19 types of amino acids.
  • Example 1 Blood samples and dementia diagnosis results obtained in Example 1, blood concentrations (nmol/ml) of the 19 amino acids measured in Example 1, and 11 test items measured in Example 7 The test values, the characteristic values of two types of physical characteristics, and the test values of one type of test item measured in Example 8 were used (total of 88 cases). As described in Example 1, these 88 cases were classified into an AD onset group (23 cases) and an AD non-onset group (65 cases). A whole blood sample was obtained from the blood samples, and hemoglobin A1c (%) in the whole blood was measured by the latex agglutination method.
  • a method for discriminating two groups, an AD non-onset group and an AD onset group including a variable to which a plasma amino acid concentration value is substituted and a variable to which a test value of a general biochemical index or a characteristic value of a physical characteristic is substituted.
  • a multivariate discriminant multivariate function
  • a logistic regression formula was used as the multivariate discriminant.
  • a combination of 6 variables to be included in the logistic regression equation is selected from the plasma concentration values of the 19 amino acids described above, and 5 plasma concentration values are selected, and 1 test value or characteristic value is selected from Group 3 below. Under these conditions, a search for a logistic regression formula with a good ability to discriminate between the AD non-onset group and the AD onset group was performed.
  • Group 3 is a group composed of the remaining 13 elements excluding body weight and hemoglobin A1c (HbA1c) in whole blood, which constitute Group 2 described in Example 8.
  • Table 6 shows the number and percentage of formulas in which the ROC_AUC value in discriminating between the AD non-onset group and the AD onset group increased by incorporating variables other than the 19 types of amino acids.
  • amino acid-related metabolites 3h-Kyn, 5h-Indole-3-acetic acid, Anthranilic acid, Indole-3-acetic acid, Indole-3-lactic acid, Kynurenic acid, Picolinic acid, Quinolinic acid, Xanthurenic acid, and Neopterin
  • blood concentrations nmol/ml
  • 15 types that can be quantified from the viewpoint of recovery rate, peak shape, and stability using the above-described measurement method (A), and that concentrations above the lower limit of quantification concentration were measured in more than half of the samples (59 cases).
  • amino acid-related metabolites of and thioproline were measured in blood (nmol/ml).
  • Blood samples from 164 people aged 50 years or older diagnosed with MCI and 2 people aged 50 years or older diagnosed with normal cognitive function, and cognition by dementia specialists 9 months to 24 months after sample collection Disease diagnosis information was acquired (total of 166 cases). According to the acquired dementia diagnostic information, these 166 cases were classified into a dementia onset group (AD onset: 35 cases, DLB onset: 2 cases, total 37 cases) and a dementia non-onset group (129 cases).
  • dementia non-onset refers to having either MCI or healthy cognitive function at the time of diagnosis.
  • blood concentrations (nmol/ml) of the 19 amino acids were measured from the obtained blood samples using the measurement method (A) described above.
  • the fitting of the multivariate logistic regression formula means substituting the sample data into the amino acid values of the multivariate logistic regression formula described in Example 2.
  • ROC_AUC was used for evaluation of discrimination ability.
  • Example 11 The sample data used in Example 11 was used.
  • the fitting of the multivariate logistic regression formula means substituting the sample data into the amino acid values of the multivariate logistic regression formula described in Example 3.
  • ROC_AUC was used for evaluation of discrimination ability.
  • Example 11 The sample data used in Example 11 was used.
  • the fitting of the multivariate logistic regression formula means substituting the sample data into the amino acid values of the multivariate logistic regression formula described in Example 4.
  • ROC_AUC was used for evaluation of discrimination ability.
  • ROC_AUC of these logistic regression formulas (the number of variables included in the formula is 4) is shown in [8. Four-variable formula including amino acids]. These logistic regression equations are useful for the evaluation described in Example 11 because the ROC_AUC values corresponding to these 708 logistic regression equations are as high as 0.64 or more, even at the lowest. Note that the following [8. Four-variable formula containing amino acids] includes, for each formula, the variables included in the formula, the ROC_AUC value in Example 4, the ROC_AUC value in Example 13, the false positive rate in Example 18 described later, and the The ROC_AUC value in Example 21 and the ROC_AUC value in Example 24, which will be described later, are shown.
  • Example 11 The sample data used in Example 11 was used.
  • the fitting of the multivariate logistic regression equation means substituting the sample data into the amino acid values of the multivariate logistic regression equation described in Example 5.
  • ROC_AUC was used for evaluation of discrimination ability.
  • ROC_AUC of these logistic regression formulas (the number of variables included in the formula is 5) is shown in [9. A five-variable formula including amino acids]. These logistic regression equations are useful for the evaluation described in Example 11 because the ROC_AUC values corresponding to these 1,009 logistic regression equations are as high as 0.65 or higher, even at the lowest. Note that the following [9. Five-variable formula containing amino acids] includes, for each formula, the variables included in the formula, the ROC_AUC value in Example 5, the ROC_AUC value in Example 14, the false positive rate in Example 19 described later, and the The ROC_AUC value in Example 22 and the ROC_AUC value in Example 25, which will be described later, are shown.
  • Example 11 The sample data used in Example 11 was used.
  • the fitting of the multivariate logistic regression formula means substituting the sample data into the amino acid values of the multivariate logistic regression formula described in Example 6.
  • ROC_AUC was used for evaluation of discrimination ability.
  • ROC_AUC of these logistic regression formulas (the number of variables included in the formula is 6) is shown in [10. 6-variable formula including amino acids]. These logistic regression equations are useful for the evaluation described in Example 11 because the ROC_AUC values corresponding to these 1,965 logistic regression equations are as high as 0.64 or higher, even at the lowest.
  • the following [10. Six-variable formula containing amino acids] includes, for each formula, the variables included in the formula, the ROC_AUC value in Example 6, the ROC_AUC value in Example 15, the false positive rate in Example 20 described later, and the The ROC_AUC value in Example 23 and the ROC_AUC value in Example 26, which will be described later, are shown.
  • the multivariate logistic regression equation (multivariate function) described in Example 2 which includes two of the 19 types of amino acids as variables, is applied, and the dementia onset group and The false-positive rate when discriminating the dementia non-onset group was obtained.
  • the fitting of the multivariate logistic regression formula means substituting the sample data into the amino acid values of the multivariate logistic regression formula described in Example 2.
  • the cutoff value for discriminating between the dementia onset group and the dementia non-onset group is the sample data described in Example 1 and the multivariate logistic regression equation described in Example 2. It was obtained as a point at which the specificity was 95%. .
  • logistic regression formulas (the number of variables included in the formula is 2), the list of false positive rates in discriminating between the dementia non-development group and the dementia development group for the above-mentioned health checkup subjects, of [6. A two-variable formula including amino acids]. Since the false-positive rate corresponding to these 121 logistic regression equations is as low as less than 16% at the highest, these two-variable logistic regression equations represent a population of people presumed to have cognitively healthy or MCI ( For example, it is useful for "evaluating the risk of developing dementia in the future (e.g., 2-group discrimination as to whether the risk of developing dementia in the future is high or low, etc.)".
  • Example 16 The sample data used in Example 16 was used. Applying the multivariate logistic regression equation (multivariate function) described in Example 3, including 3 of the 19 types of amino acids as variables, false when discriminating between the dementia onset group and the dementia non-onset group A positive rate was obtained.
  • the false positive rate refers to the ratio of the dementia onset group that was erroneously discriminated by the multivariate logistic regression equation described in Example 3 among the sample data (544 non-dementia patients) described above.
  • the cutoff value for discriminating between the dementia onset group and the dementia non-onset group is the sample data described in Example 1 and the multivariate logistic regression equation described in Example 3. It was obtained as a point at which the specificity was 95%.
  • the specificity is the dementia non-development group by the multivariate logistic regression formula described in Example 3 among the dementia non-developers (65 cases) in the sample data described in Example 1. It was correctly discriminated. Percentage.
  • Example 16 The sample data used in Example 16 was used. Applying the multivariate logistic regression equation (multivariate function) described in Example 4, which includes 4 of the 19 types of amino acids as variables, false when discriminating between the dementia onset group and the dementia non-onset group A positive rate was obtained.
  • the false positive rate refers to the ratio of the dementia onset group erroneously discriminated by the multivariate logistic regression equation described in Example 4 among the sample data (544 non-dementia patients) described above.
  • the cutoff value for discriminating between the dementia onset group and the dementia non-onset group is the sample data described in Example 1 and the multivariate logistic regression equation described in Example 4. It was obtained as a point at which the specificity was 95%.
  • the specificity is the non-dementia non-development group (65 cases) in the sample data described in Example 1, and the non-dementia non-development group by the multivariate logistic regression formula described in Example 4. Percentage.
  • Example 16 The sample data used in Example 16 was used. Applying the multivariate logistic regression equation (multivariate function) described in Example 5, including 5 of the 19 types of amino acids as variables, false when discriminating between the dementia onset group and the dementia non-onset group A positive rate was obtained.
  • the false positive rate refers to the ratio of the dementia onset group erroneously discriminated by the multivariate logistic regression equation described in Example 5 in the sample data (544 non-dementia patients).
  • the cutoff value for discriminating between the dementia onset group and the dementia non-onset group is the sample data described in Example 1 and the multivariate logistic regression equation described in Example 5. It was obtained as a point at which the specificity was 95%. .
  • the specificity is the dementia non-development group by the multivariate logistic regression formula described in Example 5 among the dementia non-developers (65 cases) in the sample data described in Example 1. It was correctly discriminated. Percentage.
  • Example 16 The sample data used in Example 16 was used. Applying the multivariate logistic regression equation (multivariate function) described in Example 6, including 6 of the 19 types of amino acids as variables, false when discriminating between the dementia onset group and the dementia non-onset group A positive rate was obtained.
  • the false positive rate refers to the ratio of the dementia onset group erroneously discriminated by the multivariate logistic regression formula described in Example 6 among the sample data (544 non-dementia patients) described above.
  • the cutoff value for discriminating between the dementia onset group and the dementia non-onset group is the sample data described in Example 1 and the multivariate logistic regression equation described in Example 6. It was obtained as a point at which the specificity was 95%. .
  • the specificity is the dementia non-development group by the multivariate logistic regression formula described in Example 6 among the dementia non-developers (65 cases) in the sample data described in Example 1. It was correctly discriminated. Percentage.
  • Data of 120 people with MCI and 120 people with normal cognitive function were extracted by propensity score matching using age and gender as variables for 219 people with MCI aged 50 and over and 220 people with normal cognitive function aged 50 and over. and used as data for formula derivation.
  • a logistic regression equation (6-variable logistic regression equation) that discriminates MCI subjects from those with normal cognitive function using the blood amino acid concentrations (nmol/ml) of Cit, Lys, Orn, Ser, Thr, and Trp as variables for formula-derived data ).
  • the first cut-off value is the point where the specificity is 60%
  • the point where the specificity is 90% is the second cut. Off value.
  • “Rank A” if the value of the 6-variable logistic regression equation is less than the first cutoff value
  • “Rank B” if the first cutoff value or more and less than the second cutoff value, the second cutoff value or more
  • the case was designated as "rank C”.
  • this "rank B” and “rank C” are rank B and rank C in AILS (cognitive function decline) in AminoIndex (registered trademark) Lifestyle-related disease risk screening (AILS (registered trademark)) corresponds to
  • AILS cognitive function decline
  • rank in Amino Index registered trademark
  • Lifestyle-related disease risk screening AILS (registered trademark)
  • Subjects who were ranked B or C were included.
  • the fact that the AILS (cognitive function decline) was rank B or rank C means that the possibility of current cognitive function decline was evaluated to be high.
  • these 110 cases were classified into a dementia onset group (AD onset 28 cases, DLB onset 2 cases, total 30 cases) and a dementia non-onset group (80 cases).
  • the fitting of the multivariate logistic regression formula means substituting the aforementioned sample data for the amino acid values of the multivariate logistic regression formula described in Example 4.
  • ROC_AUC was used for evaluation of discrimination ability.
  • ROC_AUC The list of ROC_AUC of these logistic regression formulas (the number of variables included in the formula is 4) is shown in [8. Four-variable formula including amino acids]. Since the lowest ROC_AUC value corresponding to these 708 logistic regression equations is as high as 0.60 or more, these logistic regression equations are highly likely to have cognitive decline due to some means such as testing. (e.g., AILS (cognitive decline) rank B or rank C) "Evaluation of the risk of developing dementia in the future (e.g., whether the risk of developing dementia in the future is high It is useful for 2-group discrimination of low or not, etc.).
  • AILS cognitive decline
  • rank B or rank C "Evaluation of the risk of developing dementia in the future (e.g., whether the risk of developing dementia in the future is high It is useful for 2-group discrimination of low or not, etc.).
  • Example 21 The sample data used in Example 21 was used.
  • the fitting of the multivariate logistic regression equation means substituting the aforementioned sample data for the amino acid values of the multivariate logistic regression equation described in Example 5.
  • ROC_AUC was used for evaluation of discrimination ability.
  • Example 21 The sample data used in Example 21 was used.
  • the fitting of the multivariate logistic regression formula means substituting the aforementioned sample data for the amino acid values of the multivariate logistic regression formula described in Example 6.
  • ROC_AUC was used for evaluation of discrimination ability.
  • AILS cognitive function decline
  • AminoIndex registered trademark
  • Lifestyle-related disease risk screening AILS (registered trademark)
  • Those who were ranked C were targeted.
  • the fact that the AILS (cognitive function decline) was rank C means that it was evaluated that there is a high possibility that the cognitive function is currently declining.
  • these 52 cases were classified into a dementia onset group (AD onset: 12 cases, DLB onset: 1 case, total 13 cases) and a dementia non-onset group (39 cases).
  • the fitting of the multivariate logistic regression formula means substituting the aforementioned sample data for the amino acid values of the multivariate logistic regression formula described in Example 4.
  • ROC_AUC was used for evaluation of discrimination ability.
  • ROC_AUC of these logistic regression formulas (the number of variables included in the formula is 4) is shown in [8. Four-variable formula including amino acids]. Since the lowest ROC_AUC value corresponding to these 708 logistic regression equations is as high as 0.53 or more, these logistic regression equations are highly likely to have cognitive decline due to some means such as testing. "Evaluation of the risk of developing dementia in the future (e.g., whether the risk of developing dementia in the future is high or low 2 group discrimination, etc.)”.
  • Example 24 The sample data used in Example 24 was used.
  • the fitting of the multivariate logistic regression equation means substituting the aforementioned sample data for the amino acid values of the multivariate logistic regression equation described in Example 5.
  • ROC_AUC was used for evaluation of discrimination ability.
  • Example 24 The sample data used in Example 24 was used.
  • the fitting of the multivariate logistic regression formula means substituting the aforementioned sample data for the amino acid values of the multivariate logistic regression formula described in Example 6.
  • ROC_AUC was used for evaluation of discrimination ability.
  • Blood samples from 114 individuals aged 50 and older diagnosed with MCI and 1 patient aged 50 and older diagnosed with normal cognitive function, and by a dementia specialist approximately 9 months to 27 months after sample acquisition Dementia diagnosis information was obtained (total of 115 cases). According to the acquired dementia diagnosis information, these 115 cases were classified into a dementia onset group (AD onset 49 cases, DLB onset 5 cases, total 54 cases) and a dementia non-onset group (61 cases).
  • dementia-free refers to either MCI or cognitively healthy at the time of diagnosis at least about 21 months after blood sample acquisition.
  • blood concentrations (nmol/ml) of the 19 amino acids were measured from the obtained blood samples using the measurement method (A) described above.
  • a multivariate logistic regression equation (multivariate function) was created including one and a binary variable (dummy variable) regarding the presence or absence of the APOE ⁇ 4 allele.
  • the value of the dummy variable was set to 0 when the APOE ⁇ 4 allele was not possessed and 1 when the APOE ⁇ 4 allele was possessed.
  • the ability to discriminate between the dementia onset group and the dementia non-onset group by the created multivariate logistic regression formula is a univariate logistic regression consisting of one out of 20 variables composed of the 19 types of amino acids and BCAA_sum. It was evaluated by comparing the ability to discriminate between the dementia onset group and the dementia non-onset group.
  • ROC_AUC was used for evaluation of discrimination ability.
  • ROC_AUC is a value obtained by subtracting the ROC_AUC of the univariate regression from the ROC_AUC of the bivariate regression.
  • the addition of APOE ⁇ 4 allele possession information increases ROC_AUC by 0.071 to 0.153. It is useful for "evaluation of the risk of developing dementia in the future (for example, 2-group discrimination as to whether the risk of developing dementia in the future is high or low, etc.)" for a group including people.
  • the bivariate logistic regression equations of BCAA_sum, Val, Leu, Ile, Trp, or the combination of Gly and APOE ⁇ 4 allele-bearing information each have a high ROC_AUC of 0.700 or more, and thus are considered useful for the above evaluation.
  • Example 27 The sample data used in Example 27 was used. Based on the APOE genetic information of the 115 cases, 75 APOE ⁇ 4 allele non-bearing groups (AD onset 26 cases, DLB onset 1 case, dementia non-onset 48 cases) and APOE ⁇ 4 allele carrying group 40 cases (AD onset 23 cases, 4 cases with DLB and 13 cases without dementia). In each stratified group, a univariate logistic regression equation consisting of one of the 20 variables was created, and the ability to discriminate between the dementia onset group and the dementia non-onset group was evaluated. ROC_AUC was used for evaluation of discrimination ability.
  • ROC_AUC A list of ROC_AUC of these logistic regression formulas (the number of variables included in the formula is one) is shown in Table 9 below.
  • ROC_AUC differs between the APOE ⁇ 4 allele-bearing group and the APOE ⁇ 4 allele-non-bearing group.
  • the ROC_AUC of BCAA_sum, Leu, and Val in the APOE ⁇ 4 allele non-carrier group is as high as 0.700 or higher, so when the evaluation target is limited to APOE ⁇ 4 allele non-carriers, using these variables is useful for the above evaluation. It is considered to be
  • the present invention can be widely implemented in many industrial fields, especially in fields such as pharmaceuticals, foods, and medical care, and is extremely useful.
  • evaluation device 102 control unit 102a reception unit 102b specification unit 102c formula creation unit 102d evaluation unit 102d1 calculation unit 102d2 conversion unit 102d3 generation unit 102d4 classification unit 102e result output unit 102f transmission unit 104 communication interface unit 106 storage unit 106a measurement data file 106b Index state information file 106c Designated index state information file 106d Formula related information database 106d1 Formula file 106e Evaluation result file 108 Input/output interface unit 112 Input device 114 Output device 200 Client device (terminal device (information communication terminal device)) 300 network 400 database device

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Abstract

The present invention addresses the problem of providing an evaluating method and the like capable of providing highly reliable information that can be used as a reference for understanding a risk of developing dementia in the future. In an embodiment of the present invention, a risk of developing dementia in the future is evaluated for an evaluation target using at least one value among: concentration values of 19 types of amino acid (Ala, Arg, Asn, Cit, Gln, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, and Val) in blood of the evaluation target; values of 25 types of amino acid-related metabolite (3h-Kyn, 5h-Indole-3-acetic acid, Anthranilic acid, Indol-3-acetic acid, Indole-3-lactic acid, Kynurenic acid, Picolinic acid, Quinolinic acid, Serotonin, Xanthurenic acid, Neopterin, 1-Mehis, 3-Mehis, ADMA, b-AiBA, Cystathionine, GABA, hArg, Kyn, N6-acetyl-L-lysine, N8-acetyl-Spd, SDMA, Thioproline, aABA, and Spd) in the blood; test values of 13 types of test item (WBC, RBC, Hb, Ht, folic acid, LDLC, Alb, prealbumin, CRP, TG, uric acid, γGTP, and HbA1c) in the blood; and two types of body characteristic (BMI and body weight) of the evaluation target.

Description

認知症の将来の発症リスクの評価方法Evaluation method of future onset risk of dementia
　本発明は、認知症の将来の発症リスクの評価方法、算出方法、評価装置、算出装置、評価プログラム、算出プログラム、記録媒体、評価システム、および端末装置に関するものである。 The present invention relates to an evaluation method, a calculation method, an evaluation device, a calculation device, an evaluation program, a calculation program, a recording medium, an evaluation system, and a terminal device for the future onset risk of dementia.
　認知症は、後天的な脳の病変により正常に発達した知的機能が全般的かつ持続的に低下し日常生活に支障を生じた状態を指し、「通常、慢性あるいは進行性の脳疾患によって生じ、記憶、思考、見当識、理解、計算、学習、言語、判断等多数の高次大脳機能の障害からなる症候群」と定義される疾患である（非特許文献１）。複数からなる認知症の原因疾患のうち、約６割と最も高い割合を占めるのがアルツハイマー型認知症（Alzheimer’s　Disease：以下、ＡＤと記す場合がある。）である。 Dementia refers to a condition in which normally developed intellectual function is impaired in general and persistently due to acquired brain lesions, resulting in difficulty in daily life. , memory, thinking, orientation, comprehension, calculation, learning, language, judgment, etc.” syndrome” (Non-Patent Document 1). Alzheimer's disease (hereinafter sometimes referred to as AD) accounts for the highest proportion of about 60% of the multiple diseases that cause dementia.
　ＡＤの典型的な神経病理的特徴としては、脳における老人班および神経原繊維変化が挙げられる。老人班の原因はアミロイドβ（Ａβ）と呼ばれるタンパク質の沈着であり、神経原繊維変化の原因は過剰にリン酸化されたタウタンパク質であることが分かっている。近年行われた大規模観察研究により、これらの病理的特徴はＡＤを発症する以前から始まっていることが明らかになっている（非特許文献２）。近年、脳組織におけるＡβおよびリン酸化タウタンパク質の蓄積ならびに脳組織の委縮を定量化する手法として、ポジトロン断層撮影法（ＰＥＴ（positron　emission　tomography））、シングルフォトン断層撮影法（ＳＰＥＣＴ（signle　photon　emission　computed　tomography））、および核磁共鳴画像法（ＭＲＩ（magnetic　resonance　imaging））等の画像診断技術が提供されている。しかしながら、これらの画像診断技術のいずれも単独での確定診断法としては推奨されていない。そのため、ＡＤは、神経心理検査や、問診による臨床症状所見等との総合評価に基づいて診断されているのが現状である。この他、脳脊髄液（ＣＳＦ（cerebrospinal　fluid））中のＡβおよびリン酸化タウタンパク質の濃度を指標としたＡＤの診断技術も提供されている（非特許文献３、４）。 Typical neuropathological features of AD include senile plaques and neurofibrillary tangles in the brain. The cause of senile plaques is the deposition of a protein called amyloid β (Aβ), and the cause of neurofibrillary tangles is known to be hyperphosphorylated tau protein. Large-scale observational studies conducted in recent years have revealed that these pathological features begin before the onset of AD (Non-Patent Document 2). In recent years, positron emission tomography (PET) and single photon emission computed tomography (SPECT) have been used as methods to quantify the accumulation of Aβ and phosphorylated tau protein in brain tissue and the atrophy of brain tissue. tomography), and magnetic resonance imaging (MRI). However, none of these imaging techniques are recommended alone as definitive diagnosis. Therefore, AD is currently diagnosed based on a neuropsychological examination and a comprehensive evaluation including clinical symptom findings and the like obtained through interviews. In addition, a diagnostic technique for AD using the concentrations of Aβ and phosphorylated tau protein in cerebrospinal fluid (CSF) as indices has been provided (Non-Patent Documents 3 and 4).
　現在、ＡＤの治療薬としてはアセチルコリンエステラーゼ阻害剤やＮＭＤＡ（N-methyl-D-aspartic　acid）受容体阻害剤が用いられているが、いずれの薬も症状の進行を一定期間遅延させる効果しか得られていないので、根本治療に要求される病態修飾療法は未だ確立されていない。また、Ａβやリン酸化タウタンパク質の蓄積といった神経病理的知見に基づく抗体医薬等の開発も行われているが、発症後の患者に対しては効果を発揮しないことが明らかになりつつある。そのため、近年では、ＡＤを発症する前段階を介入対象とすることが適切であるとの考え方が一般的である。 Currently, acetylcholinesterase inhibitors and NMDA (N-methyl-D-aspartic acid) receptor inhibitors are used as therapeutic agents for AD, but both of these drugs only have the effect of delaying the progression of symptoms for a certain period of time. Therefore, no pathophysiological modification therapy required for radical treatment has been established yet. Antibody drugs and the like have also been developed based on neuropathological findings such as the accumulation of Aβ and phosphorylated tau protein, but it is becoming clear that they are not effective for post-onset patients. Therefore, in recent years, it is generally thought that it is appropriate to target the stage prior to the onset of AD for intervention.
　このような背景を踏まえ、ＡＤ発症前の早期診断および早期介入によるＡＤ発症予防の必要性が高まっている。ここで、軽度認知障害（Mild　Cognitive　Impairment：以下、ＭＣＩと記す場合がある。）は、年齢や正常な老化と比べて認知機能に問題はあるが、日常生活に支障はなく認知症との診断には至らない、さまざまな認知症の前段階または境界例と考えられる状態を指す。現状、主に２つの診断基準が提唱され、広く受け入れられている（非特許文献５、６）。ＭＣＩと診断された患者の年間１０～２０％が数年後にＡＤを発症することが明らかになっている。しかし、ＭＣＩ罹患者の全てがＡＤを発症するとは限らず、例えば血管性認知症（Vascular　Dementia：以下、ＶａＤと記す場合がある。）やレヴィー小体型認知症（Dementia　with　Lewy　bodies：以下、ＤＬＢと記す場合がある。）、前頭側頭葉型認知症（Frontotemporal　Dementia：以下、ＦＴＤと記す場合がある。）等のＡＤとは異なるタイプの認知症を発症することもある。さらに、認知症のタイプごとに治療法が異なる。また、神経変性病理を持たず認知症を発症しない、もしくは認知機能が健常に戻るＭＣＩ罹患者も少数ながら存在する（非特許文献７）。よって、ＭＣＩ罹患の段階で、臨床症状のみから病態に適した治療方針を判断することは極めて困難である。そのため、さまざまな疾患を背景として認知機能低下を示すＭＣＩの集団について、認知症を発症する可能性が高い集団と認知症を発症しない可能性が高い集団を判別する発症予測技術（例えば、ＡＤを発症するか否か、すなわちアルツハイマー病理を背景としたＭＣＩ罹患者（MCI　due　to　AD）を判定する発症予測技術、など）を提供することにより、早期からの適切な介入および治療法の選択に役立つことが期待される。 Against this background, there is a growing need for early diagnosis and early intervention to prevent the onset of AD. Here, Mild Cognitive Impairment (hereinafter sometimes referred to as MCI) has problems in cognitive function compared to age and normal aging, but it does not interfere with daily life and is diagnosed as dementia. Refers to conditions considered to be pre-stage or borderline cases of various dementias that do not lead to dementia. At present, mainly two diagnostic criteria have been proposed and are widely accepted (Non-Patent Documents 5 and 6). It has been shown that 10-20% of patients diagnosed with MCI annually develop AD several years later. However, not all MCI sufferers develop AD. ), frontotemporal dementia (hereinafter sometimes referred to as FTD), and other types of dementia different from AD may develop. Furthermore, different types of dementia have different treatments. In addition, there are a small number of MCI patients who do not have neurodegenerative pathology and do not develop dementia, or whose cognitive function returns to normal (Non-Patent Document 7). Therefore, it is extremely difficult to determine a treatment policy suitable for the pathology only from clinical symptoms at the stage of MCI. Therefore, for MCI populations showing cognitive decline against the background of various diseases, onset prediction technology (for example, AD By providing onset prediction technology that determines whether or not it will develop, that is, MCI due to Alzheimer's pathology (MCI due to AD), etc.), it will be useful for selecting appropriate intervention and treatment from an early stage It is expected.
　また、近年、ＡＤ診断技術として用いられるアミロイドＰＥＴおよびタウＰＥＴ等の画像診断法のＡＤの発症予測指標としての適用について研究が行われているものの、自覚症状のない無症状期の患者にこれらの侵襲性の高い検査を受診させることは現実的とはいえない。そのため、より簡便且つ安価なスクリーニング検査技術が求められる。 In recent years, studies have been conducted on the application of diagnostic imaging methods such as amyloid PET and tau PET, which are used as AD diagnostic techniques, as indicators for predicting the onset of AD. It is not realistic to have a patient undergo a highly invasive examination. Therefore, a simpler and cheaper screening test technique is required.
　ところで、血液中の特定のアミノ酸濃度を指標としたＡＤやＭＣＩの診断技術が考案されている（特許文献１、２、３）。他方、血液検査によりＭＣＩを判別する技術としては、血液中のペプチド断片濃度を測定し指標とする技術が考案されている（特許文献４）。 By the way, diagnostic techniques for AD and MCI have been devised using the concentration of specific amino acids in blood as an index ( Patent Documents 1, 2, and 3). On the other hand, as a technique for determining MCI by a blood test, a technique for measuring the peptide fragment concentration in blood and using it as an index has been devised (Patent Document 4).
特開２０１１－２４２２１７号公報JP 2011-242217 A 国際公開第２０２０／０６７３８６号WO2020/067386 国際公開第２０２０／０９０７７４号WO2020/090774 特開２０１６－０２８２４４号公報JP 2016-028244 A
　しかしながら、血液検査で得られる血液中のアミノ酸およびアミノ酸関連代謝物の濃度や、血液検査で得られる血液中の血算検査項目または生化学検査項目の検査値、これらの値が代入される変数を含む式の値を指標として、認知症の将来の発症リスクを判定するための簡便且つ安価な技術に関しては、開発されていないまたは実用化されていない、という課題があった。なお、以下、血算検査項目および生化学検査項目を総称して「検査項目」と記す場合がある。 However, the concentration of amino acids and amino acid-related metabolites in the blood obtained by blood tests, the test values of blood count items or biochemical test items in the blood obtained by blood tests, and the variables into which these values are substituted There is a problem that a simple and inexpensive technique for determining the risk of developing dementia in the future using the value of the expression containing the expression as an index has not been developed or put into practical use. Hereinafter, blood count test items and biochemical test items may be collectively referred to as "test items".
　本発明は、上記に鑑みてなされたもので、認知症の将来の発症リスクを知る上で参考となり得る信頼性の高い情報を提供することができる評価方法、算出方法、評価装置、算出装置、評価プログラム、算出プログラム、記録媒体、評価システム、および端末装置を提供することを目的とする。 The present invention has been made in view of the above, and an evaluation method, calculation method, evaluation device, calculation device, which can provide highly reliable information that can be helpful in knowing the risk of developing dementia in the future, An object of the present invention is to provide an evaluation program, a calculation program, a recording medium, an evaluation system, and a terminal device.
　上述した課題を解決し、目的を達成するために、本発明にかかる評価方法は、評価対象の血液中の１９種類のアミノ酸の濃度値、前記血液中の２５種類のアミノ酸関連代謝物の値（濃度値または面積値）、前記血液中の１３種類の検査項目の検査値、および前記評価対象の２種類の身体特徴（BMI（Body　Mass　Index）および体重）の値のうちの少なくとも１つの値、または、前記少なくとも１つの値が代入される変数を含む式および前記少なくとも１つの値を用いて算出された前記式の値を用いて、前記評価対象について認知症の将来の発症リスクを評価する評価ステップを含むこと、を特徴とする。 In order to solve the above-mentioned problems and achieve the object, the evaluation method according to the present invention includes concentration values of 19 amino acids in the blood to be evaluated, values of 25 amino acid-related metabolites in the blood ( concentration value or area value), test values of the 13 types of test items in the blood, and at least one value of the two types of physical characteristics (BMI (Body Mass Index) and body weight) to be evaluated, Alternatively, using a formula containing a variable to which the at least one value is substituted and the value of the formula calculated using the at least one value, the evaluation of evaluating the risk of developing dementia in the future for the subject. characterized by comprising a step.
　ここで、前記１９種類のアミノ酸は、Ala、Arg、Asn、Cit、Gln、Gly、His、Ile、Leu、Lys、Met、Orn、Phe、Pro、Ser、Thr、Trp、Tyr、およびValである。なお、本明細書では、各種アミノ酸を主に略称で表記するが、それらの正式名称は以下の通りである。
（略称）      （正式名称）
Ala           Alanine
Arg           Arginine
Asn           Asparagine
Cit           Citrulline
Gln           Glutamine
Gly           Glycine
His           Histidine
Ile           Isoleucine
Leu           Leucine
Lys           Lysine
Met           Methionine
Orn           Ornithine
Phe           Phenylalanine
Pro           Proline
Ser           Serine
Thr           Threonine
Trp           Tryptophan
Tyr           Tyrosine
Val           Valine Here, the 19 kinds of amino acids are Ala, Arg, Asn, Cit, Gln, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, and Val. . In the present specification, various amino acids are mainly abbreviated, but their official names are as follows.
(abbreviation) (formal name)
Ala Alanine
Arg Arginine
Asn Asparagine
Cit Citrulline
Gln Glutamine
Gly Glycine
His Histidine
Ile Isoleucine
Leu Leucine
Lys Lysine
met-methionine
Orn Ornithine
Phe Phenylalanine
Pro Proline
Ser Serine
Thr Threonine
Trp Tryptophan
Tyr Tyrosine
Val Valine
　また、前記２５種類のアミノ酸関連代謝物は、3h-Kyn、5h-Indole-3-acetic　acid、Anthranilic　acid、Indol-3-acetic　acid、Indole-3-lactic　acid、Kynurenic　acid、Picolinic　acid、Quinolinic　acid、Serotonin、Xanthurenic　acid、Neopterin、1-Mehis、3-Mehis、ADMA、b-AiBA、Cystathionine、GABA、hArg、Kyn、N6-acetyl-L-lysine、N8-acetyl-spd、SDMA、Thioproline、aABA、およびSpdである。なお、本明細書では、各種アミノ酸関連代謝物を主に略称で表記するが、それらの正式名称は以下の通りである。
（略称）                           （正式名称）
3h-Kyn                             3-hydroxy-L-kynurenine
5h-Indole-3-acetic　acid           5-hydroxy-3-indoleacetic　acid
Anthranilic　acid                  Anthranilic　acid
Indol-3-acetic　acid               3-indoleacetic　acid
Indole-3-lactic　acid       Indole-3-lactic　acid
Kynurenic　acid                           Kynurenic　acid
Picolinic　acid                           Picolinic　acid
Quinolinic　acid                   Quinolinic　acid
Serotonin                          Serotonin
Xanthurenic　acid                  Xanthurenic　acid
Neopterin                          Neopterin
1-Mehis                            N(pi)-Methyl-L-histidine
3-Mehis                            N(tau)-Methyl-L-histidine
ADMA                               Asymmetric　dimethylarginine
b-AiBA                             L-3-Aminoisobutyric　acid
Cystathionine                      L-Cystathionine
GABA                               4-Aminobutyric　Acid
hArg                               L-Homoarginine
Kyn                                L-Kynurenine
N6-acetyl-L-lysine                 N-epsilon-Acetyl-L-lysine
N8-acetyl-spd                      N8-Acetylspermidine
SDMA                               Symmetric　dimethylarginine
Thioproline                        L-Thioproline
aABA                               3-Aminobutanoic　acid
Spd                                Spermidine In addition, the 25 amino acid-related metabolites are 3h-Kyn, 5h-Indole-3-acetic acid, Anthranilic acid, Indol-3-acetic acid, Indole-3-lactic acid, Kynurenic acid, Picolinic acid, Quinolinic acid , Serotonin, Xanthurenic acid, Neopterin, 1-Mehis, 3-Mehis, ADMA, b-AiBA, Cystathionine, GABA, hArg, Kyn, N6-acetyl-L-lysine, N8-acetyl-spd, SDMA, Thioproline, aABA, and Spd. In the present specification, various amino acid-related metabolites are mainly abbreviated, and their formal names are as follows.
(abbreviation) (formal name)
3h-Kyn 3-hydroxy-L-kynurenine
5h-Indole-3-acetic acid 5-hydroxy-3-indoleacetic acid
Anthranilic acid
Indol-3-acetic acid 3-indoleacetic acid
Indole-3-lactic acid Indole-3-lactic acid
Kynurenic acid Kynurenic acid
Picolinic acid Picolinic acid
Quinolinic acid Quinolinic acid
SerotoninSerotonin
Xanthurenic acid Xanthurenic acid
Neopterin Neopterin
1-Mehis N(pi)-Methyl-L-histidine
3-Mehis N(tau)-Methyl-L-histidine
ADMA Asymmetric dimethylarginine
b-AiBA L-3-Aminoisobutyric acid
Cystathionine L-Cystathionine
GABA 4-Aminobutyric Acid
hArg L-Homoarginine
Kyn L-Kynurenine
N6-acetyl-L-lysine N-epsilon-Acetyl-L-lysine
N8-acetyl-spd N8-Acetylspermidine
SDMA symmetric dimethylarginine
Thioproline L-Thioproline
aABA 3-Aminobutanoic acid
Spd Spermidine
　また、前記１３種類の検査項目は、WBC、RBC、Hb、Ht、葉酸、LDLC、Alb、プレアルブミン、CRP、TG、尿酸、γGTP、およびHbA1cである。なお、本明細書では、各種検査項目を主に略称で表記するが、それらの正式名称は以下の通りである。
（略称）      （正式名称）
WBC           White　blood　cell　count
RBC           Red　blood　cell　count
Hb            Hemoglobin　content
Ht            Hematocrit　value
LDLC          Low-density　lipoprotein cholesterol
Alb           Albumin
CRP           C-reactive　protein
TG            Triglyceride
γGTP         γ-glutamyl　transpeptidase
HbA1c         Hemoglobin　A1c The 13 types of test items are WBC, RBC, Hb, Ht, folic acid, LDLC, Alb, prealbumin, CRP, TG, uric acid, γGTP, and HbA1c. In this specification, various inspection items are mainly described by abbreviated names, but their official names are as follows.
(abbreviation) (formal name)
WBC white blood cell count
RBC red blood cell count
Hb hemoglobin content
Ht Hematocrit value
LDLC Low-density lipoprotein cholesterol
Alb Albumin
CRP C-reactive protein
TG Triglyceride
γGTP γ-glutamyl transpeptidase
HbA1c Hemoglobin A1c
　また、本発明にかかる評価方法において、前記評価ステップは、Val、Leu、およびIleの前記濃度値の合計ならびにＡＰＯＥアリルの保有に関するカテゴリカル変数の値、または、前記合計が代入される変数と前記カテゴリカル変数の前記値が代入される変数とを含む式、前記合計、および前記カテゴリカル変数の前記値を用いて算出された前記式の値、を用いて、前記評価対象について認知症の将来の発症リスクを評価するものであること、を特徴とする。ここで、例えば、ＡＰＯＥε４アリルの有無に関する二値変数（ダミー変数）の値を、カテゴリカル変数の値として使用してもよい。また、例えば、ＡＰＯＥ遺伝子型に含まれるＡＰＯＥε４アリルの個数の値（０個、１個、または２個）を、カテゴリカル変数の値として使用してもよい。また、例えば、ＡＰＯＥ遺伝子に対する３種類のアイソフォームに基づくＡＰＯＥ遺伝子型の６つの分類（（ε２アリル，ε２アリル）、（ε３アリル，ε３アリル）、（ε４アリル，ε４アリル）、（ε２アリル，ε３アリル）、（ε２アリル，ε４アリル）、および（ε３アリル，ε４アリル））のそれぞれに割り当てた値を、カテゴリカル変数の値として使用してもよい。なお、本明細書では遺伝子ＡＰＯＥと表記するがその正式名称はapolipoprotein　Eである。 Further, in the evaluation method according to the present invention, the evaluation step includes the sum of the concentration values of Val, Leu, and Ile and the value of a categorical variable related to the possession of the APOE allele, or the variable into which the sum is substituted and the Using a formula containing a variable to which the value of the categorical variable is substituted, the sum, and the value of the formula calculated using the value of the categorical variable, the future of dementia for the evaluation subject characterized by evaluating the onset risk of Here, for example, the value of a binary variable (dummy variable) regarding the presence or absence of the APOEε4 allele may be used as the value of the categorical variable. Also, for example, the value of the number of APOE ε4 alleles contained in the APOE genotype (0, 1, or 2) may be used as the value of the categorical variable. Further, for example, six classifications of APOE genotypes based on three isoforms for the APOE gene ((ε2 allyl, ε2 allyl), (ε3 allyl, ε3 allyl), (ε4 allyl, ε4 allyl), (ε2 allyl, ε3 allyl), (ε2 allyl, ε4 allyl), and (ε3 allyl, ε4 allyl)) may be used as values of categorical variables. In this specification, the gene is referred to as APOE, but its formal name is apolipoprotein E.
　また、本発明にかかる評価方法において、前記評価対象の生体サンプルを用いてＡｐｏＥ遺伝子を検査する検査ステップと、前記検査ステップで得られたＡｐｏＥの遺伝型を基に前記カテゴリカル変数の値を決定する決定ステップと、をさらに含み、前記評価ステップにおいて、前記カテゴリカル変数の前記値は、前記決定ステップで決定した前記値であること、を特徴とする。 Further, in the evaluation method according to the present invention, an examination step of examining the ApoE gene using the biological sample to be evaluated; and determining the value of the categorical variable based on the ApoE genotype obtained in the examination step. and, in the evaluating step, the value of the categorical variable is the value determined in the determining step.
　また、本発明にかかる評価方法において、前記評価対象は、ＡＰＯＥε４アリルを保有しないものであり、前記評価ステップは、Ala、Arg、Asn、Cit、Gln、Gly、His、Ile、Leu、Lys、Met、Orn、Phe、Pro、Ser、Thr、Trp、Tyr、およびValの前記濃度値ならびにVal、Leu、およびIleの前記濃度値の合計のうちの少なくとも１つの値、または、前記少なくとも１つの値が代入される変数を含む式および前記少なくとも１つの値を用いて算出された前記式の値を用いて、前記評価対象について認知症の将来の発症リスクを評価するものであること、を特徴とする。 Further, in the evaluation method according to the present invention, the evaluation target does not possess the APOE ε4 allele, and the evaluation step includes Ala, Arg, Asn, Cit, Gln, Gly, His, Ile, Leu, Lys, Met , Orn, Phe, Pro, Ser, Thr, Trp, Tyr, and Val and the sum of the concentration values of Val, Leu, and Ile, or the at least one value is Using the formula containing the variables to be substituted and the value of the formula calculated using the at least one value, the risk of future development of dementia is evaluated for the evaluation subject. .
　また、本発明にかかる評価方法において、前記評価対象の生体サンプルを用いてＡｐｏＥ遺伝子を検査する検査ステップと、前記検査ステップで得られたＡｐｏＥの遺伝型を基にＡＰＯＥε４アリルを保有しているか否か確認する確認ステップと、をさらに含み、前記評価ステップにおいて、前記評価対象は、前記確認ステップでＡＰＯＥε４アリルを保有していないと確認されたものであること、を特徴とする。 Further, in the evaluation method according to the present invention, an examination step of examining the ApoE gene using the biological sample to be evaluated; and a confirmation step of confirming whether or not the subject is confirmed to have the APOE ε4 allele in the evaluation step.
　また、本発明にかかる評価方法において、前記評価ステップは、制御部を備える情報処理装置の前記制御部において実行されること、を特徴とする。 Further, in the evaluation method according to the present invention, the evaluation step is characterized by being executed by the control section of an information processing apparatus having a control section.
　また、本発明にかかる算出方法は、評価対象の血液中の前記１９種類のアミノ酸の濃度値、前記血液中の前記２５種類のアミノ酸関連代謝物の値、前記血液中の前記１３種類の検査項目の検査値、および前記評価対象の前記２種類の身体特徴の値のうちの少なくとも１つの値、ならびに、前記少なくとも１つの値が代入される変数を含む認知症の将来の発症リスクを評価するための式を用いて、前記式の値を算出する算出ステップを含むこと、を特徴とする。 In addition, the calculation method according to the present invention includes concentration values of the 19 types of amino acids in the blood to be evaluated, values of the 25 types of amino acid-related metabolites in the blood, and the 13 types of test items in the blood. and at least one value of the two physical characteristic values to be evaluated, and a variable into which the at least one value is assigned, for evaluating the risk of future onset of dementia is characterized by including a calculation step of calculating the value of the formula using the formula:
　また、本発明にかかる算出方法において、前記算出ステップは、Val、Leu、およびIleの前記濃度値の合計、ＡＰＯＥアリルの保有に関するカテゴリカル変数の値、ならびに前記合計が代入される変数と前記カテゴリカル変数の前記値が代入される変数とを含む認知症の将来の発症リスクを評価するための式を用いて、前記式の値を算出するものであること、を特徴とする。 Further, in the calculation method according to the present invention, the calculation step includes: the sum of the concentration values of Val, Leu, and Ile; the value of a categorical variable related to the possession of the APOE allele; and a variable into which the value of the Cull variable is substituted, and the value of the formula is calculated using a formula for evaluating the risk of developing dementia in the future.
　また、本発明にかかる算出方法において、前記評価対象は、ＡＰＯＥε４アリルを保有しないものであり、前記算出ステップは、Ala、Arg、Asn、Cit、Gln、Gly、His、Ile、Leu、Lys、Met、Orn、Phe、Pro、Ser、Thr、Trp、Tyr、およびValの前記濃度値ならびにVal、Leu、およびIleの前記濃度値の合計のうちの少なくとも１つの値、ならびに、前記少なくとも１つの値が代入される変数を含む認知症の将来の発症リスクを評価するための式を用いて、前記式の値を算出するものであること、を特徴とする。 Further, in the calculation method according to the present invention, the evaluation target does not have the APOE ε4 allele, and the calculation step includes Ala, Arg, Asn, Cit, Gln, Gly, His, Ile, Leu, Lys, Met , Orn, Phe, Pro, Ser, Thr, Trp, Tyr, and Val and the sum of the concentration values of Val, Leu, and Ile, and the at least one value is A formula for evaluating the future risk of dementia including the variables to be substituted is used to calculate the value of the formula.
　また、本発明にかかる算出方法において、前記算出ステップは、制御部を備える情報処理装置の前記制御部において実行されること、を特徴とする。 Further, in the calculation method according to the present invention, the calculation step is characterized by being executed by the control section of an information processing apparatus having a control section.
　また、本発明にかかる評価装置は、制御部を備える評価装置であって、前記制御部は、評価対象の血液中の前記１９種類のアミノ酸の濃度値、前記血液中の前記２５種類のアミノ酸関連代謝物の値、前記血液中の前記１３種類の検査項目の検査値、および前記評価対象の前記２種類の身体特徴の値のうちの少なくとも１つの値、または、前記少なくとも１つの値が代入される変数を含む式および前記少なくとも１つの値を用いて算出された前記式の値を用いて、前記評価対象について認知症の将来の発症リスクを評価する評価手段を備えること、を特徴とする。 Further, the evaluation apparatus according to the present invention is an evaluation apparatus comprising a control unit, wherein the control unit controls the concentration values of the 19 amino acids in the blood to be evaluated, the 25 amino acid-related At least one value of the values of metabolites, the test values of the 13 types of test items in the blood, and the values of the two types of physical characteristics to be evaluated, or the at least one value is substituted Using a formula containing a variable and the value of the formula calculated using the at least one value, an evaluation means is provided for evaluating the future risk of developing dementia for the evaluation subject.
　また、本発明にかかる評価装置は、前記少なくとも１つの値または前記式の前記値を提供する端末装置とネットワークを介して通信可能に接続されており、前記制御部は、前記端末装置から送信された前記少なくとも１つの値または前記式の前記値を受信するデータ受信手段と、前記評価手段で得られた評価結果を前記端末装置へ送信する結果送信手段と、をさらに備え、前記評価手段は、前記データ受信手段で受信した前記少なくとも１つの値または前記式の前記値を用いること、を特徴とする。 Further, the evaluation device according to the present invention is communicably connected via a network to a terminal device that provides the at least one value or the value of the expression, and the control unit receives a data receiving means for receiving the at least one value or the value of the formula; and result transmitting means for transmitting the evaluation result obtained by the evaluating means to the terminal device, wherein the evaluating means The at least one value received by the data receiving means or the value of the formula is used.
　また、本発明にかかる算出装置は、制御部を備える算出装置であって、前記制御部は、評価対象の血液中の前記１９種類のアミノ酸の濃度値、前記血液中の前記２５種類のアミノ酸関連代謝物の値、前記血液中の前記１３種類の検査項目の検査値、および前記評価対象の前記２種類の身体特徴の値のうちの少なくとも１つの値、ならびに、前記少なくとも１つの値が代入される変数を含む認知症の将来の発症リスクを評価するための式を用いて、前記式の値を算出する算出手段を備えること、を特徴とする。 Further, the calculation device according to the present invention is a calculation device comprising a control unit, wherein the control unit controls the concentration values of the 19 amino acids in the blood to be evaluated, the 25 amino acid-related At least one value among the values of metabolites, the test values of the thirteen test items in the blood, and the two physical characteristic values of the evaluation object, and the at least one value are substituted. and calculating means for calculating the value of the formula using a formula for evaluating the risk of developing dementia in the future, including the variables.
　また、本発明にかかる評価プログラムは、制御部を備える情報処理装置において実行させるための評価プログラムであって、前記制御部において実行させるための、評価対象の血液中の前記１９種類のアミノ酸の濃度値、前記血液中の前記２５種類のアミノ酸関連代謝物の値、前記血液中の前記１３種類の検査項目の検査値、および前記評価対象の前記２種類の身体特徴の値のうちの少なくとも１つの値、または、前記少なくとも１つの値が代入される変数を含む式および前記少なくとも１つの値を用いて算出された前記式の値を用いて、前記評価対象について認知症の将来の発症リスクを評価する評価ステップを含むこと、を特徴とする。 Further, an evaluation program according to the present invention is an evaluation program to be executed by an information processing apparatus having a control unit, wherein the concentration of the 19 types of amino acids in the blood to be evaluated is to be executed by the control unit. values of the 25 types of amino acid-related metabolites in the blood; test values of the 13 types of test items in the blood; and values of the two types of physical characteristics to be evaluated. value, or the formula containing the variable to which the at least one value is substituted and the value of the formula calculated using the at least one value, dementia for the subject to evaluate the risk of developing future dementia and including an evaluation step for
　また、本発明にかかる算出プログラムは、制御部を備える情報処理装置において実行させるための算出プログラムであって、前記制御部において実行させるための、評価対象の血液中の前記１９種類のアミノ酸の濃度値、前記血液中の前記２５種類のアミノ酸関連代謝物の値、前記血液中の前記１３種類の検査項目の検査値、および前記評価対象の前記２種類の身体特徴の値のうちの少なくとも１つの値、ならびに、前記少なくとも１つの値が代入される変数を含む認知症の将来の発症リスクを評価するための式を用いて、前記式の値を算出する算出ステップを含むこと、を特徴とする。 Further, a calculation program according to the present invention is a calculation program to be executed in an information processing apparatus having a control unit, and is a calculation program for executing in the control unit, the concentration of the 19 amino acids in the blood to be evaluated. values of the 25 types of amino acid-related metabolites in the blood; test values of the 13 types of test items in the blood; and values of the two types of physical characteristics to be evaluated. and a formula for evaluating the risk of future development of dementia that includes a variable into which the at least one value is substituted, and a calculating step of calculating the value of the formula. .
　また、本発明にかかる記録媒体は、一時的でないコンピュータ読み取り可能な記録媒体であって、情報処理装置に前記評価方法または前記算出方法を実行させるためのプログラム化された命令を含むこと、を特徴とする。 Further, a recording medium according to the present invention is a non-transitory computer-readable recording medium, characterized by including programmed instructions for causing an information processing device to execute the evaluation method or the calculation method. and
　また、本発明にかかる評価システムは、制御部を備える評価装置と制御部を備える端末装置とをネットワークを介して通信可能に接続して構成される評価システムであって、前記端末装置の前記制御部は、評価対象の血液中の前記１９種類のアミノ酸の濃度値、前記血液中の前記２５種類のアミノ酸関連代謝物の値、前記血液中の前記１３種類の検査項目の検査値、および前記評価対象の前記２種類の身体特徴の値のうちの少なくとも１つの値、または、前記少なくとも１つの値が代入される変数を含む式および前記少なくとも１つの値を用いて算出された前記式の値を前記評価装置へ送信するデータ送信手段と、前記評価装置から送信された、前記評価対象についての認知症の将来の発症リスクに関する評価結果を受信する結果受信手段と、を備え、前記評価装置の前記制御部は、前記端末装置から送信された前記少なくとも１つの値または前記式の前記値を受信するデータ受信手段と、前記データ受信手段で受信した前記少なくとも１つの値または前記式の前記値を用いて、前記評価対象について認知症の将来の発症リスクを評価する評価手段と、前記評価手段で得られた前記評価結果を前記端末装置へ送信する結果送信手段と、を備えること、を特徴とする。 Further, an evaluation system according to the present invention is an evaluation system configured by connecting an evaluation device having a control unit and a terminal device having a control unit so as to be communicable via a network, wherein the control of the terminal device The part is the concentration values of the 19 amino acids in the blood to be evaluated, the values of the 25 amino acid-related metabolites in the blood, the test values of the 13 test items in the blood, and the evaluation At least one value of the two types of physical characteristic values of the subject, or a formula including a variable into which the at least one value is substituted and the value of the formula calculated using the at least one value data transmission means for transmitting data to the evaluation device; and result reception means for receiving an evaluation result regarding the future risk of developing dementia for the evaluation target, which is transmitted from the evaluation device; The control unit uses data receiving means for receiving the at least one value or the value of the formula transmitted from the terminal device, and the at least one value or the value of the formula received by the data receiving means. and evaluation means for evaluating the future risk of developing dementia for the evaluation object, and result transmission means for transmitting the evaluation result obtained by the evaluation means to the terminal device. .
　また、本発明にかかる端末装置は、制御部を備えた端末装置であって、前記制御部は、評価対象についてのアルツハイマー型認知症の将来の発症リスクに関する評価結果を取得する結果取得手段を備え、前記評価結果は、前記評価対象の血液中の前記１９種類のアミノ酸の濃度値、前記血液中の前記２５種類のアミノ酸関連代謝物の値、前記血液中の前記１３種類の検査項目の検査値、および前記評価対象の前記２種類の身体特徴の値のうちの少なくとも１つの値、または、前記少なくとも１つの値が代入される変数を含む式および前記少なくとも１つの値を用いて算出された前記式の値を用いて、前記評価対象について認知症の将来の発症リスクを評価した結果であること、を特徴とする。 Further, a terminal device according to the present invention is a terminal device comprising a control unit, wherein the control unit comprises result acquisition means for acquiring an evaluation result regarding the risk of developing Alzheimer's disease in the future for an evaluation target. , the evaluation results include concentration values of the 19 types of amino acids in the blood of the evaluation object, values of the 25 types of amino acid-related metabolites in the blood, and test values of the 13 types of test items in the blood. , and at least one value of the two types of physical characteristic values to be evaluated, or an expression containing a variable into which the at least one value is substituted and the at least one value calculated using the It is characterized by being the result of evaluating the future risk of developing dementia for the evaluation object using the value of the formula.
　また、本発明にかかる端末装置は、前記評価対象について認知症の将来の発症リスクを評価する評価装置とネットワークを介して通信可能に接続されており、前記制御部は、前記少なくとも１つの値または前記式の前記値を前記評価装置へ送信するデータ送信手段をさらに備え、前記結果取得手段は、前記評価装置から送信された前記評価結果を受信すること、を特徴とする。 Further, the terminal device according to the present invention is communicably connected via a network with an evaluation device that evaluates the risk of future development of dementia for the evaluation object, and the control unit controls the at least one value or The method further comprises data transmission means for transmitting the value of the expression to the evaluation device, and the result acquisition means receives the evaluation result transmitted from the evaluation device.
　本発明によれば、認知症の将来の発症リスクを知る上で参考となり得る信頼性の高い情報を提供することができるという効果を奏する。 According to the present invention, it is possible to provide highly reliable information that can be used as a reference for knowing the risk of developing dementia in the future.
図１は、第１実施形態の基本原理を示す原理構成図である。FIG. 1 is a principle configuration diagram showing the basic principle of the first embodiment. 図２は、第２実施形態の基本原理を示す原理構成図である。FIG. 2 is a principle configuration diagram showing the basic principle of the second embodiment. 図３は、本システムの全体構成の一例を示す図である。FIG. 3 is a diagram showing an example of the overall configuration of this system. 図４は、本システムの全体構成の他の一例を示す図である。FIG. 4 is a diagram showing another example of the overall configuration of this system. 図５は、本システムの評価装置１００の構成の一例を示すブロック図である。FIG. 5 is a block diagram showing an example of the configuration of the evaluation device 100 of this system. 図６は、測定データファイル１０６ａに格納される情報の一例を示す図である。FIG. 6 is a diagram showing an example of information stored in the measurement data file 106a. 図７は、指標状態情報ファイル１０６ｂに格納される情報の一例を示す図である。FIG. 7 is a diagram showing an example of information stored in the index state information file 106b. 図８は、指定指標状態情報ファイル１０６ｃに格納される情報の一例を示す図である。FIG. 8 is a diagram showing an example of information stored in the specified index state information file 106c. 図９は、式ファイル１０６ｄ１に格納される情報の一例を示す図である。FIG. 9 is a diagram showing an example of information stored in the formula file 106d1. 図１０は、評価結果ファイル１０６ｅに格納される情報の一例を示す図である。FIG. 10 is a diagram showing an example of information stored in the evaluation result file 106e. 図１１は、評価部１０２ｄの構成を示すブロック図である。FIG. 11 is a block diagram showing the configuration of the evaluation unit 102d. 図１２は、本システムのクライアント装置２００の構成の一例を示すブロック図である。FIG. 12 is a block diagram showing an example of the configuration of the client device 200 of this system. 図１３は、本システムのデータベース装置４００の構成の一例を示すブロック図である。FIG. 13 is a block diagram showing an example of the configuration of the database device 400 of this system.
　以下に、本発明にかかる評価方法および算出方法の実施形態（第１実施形態）ならびに本発明にかかる評価装置、算出装置、評価方法、算出方法、評価プログラム、算出プログラム、記録媒体、評価システム、および端末装置の実施形態（第２実施形態）を、図面に基づいて詳細に説明する。なお、本発明はこれらの実施形態により限定されるものではない。 Below, an embodiment (first embodiment) of the evaluation method and the calculation method according to the present invention, an evaluation device, a calculation device, an evaluation method, a calculation method, an evaluation program, a calculation program, a recording medium, an evaluation system, and a terminal device (second embodiment) will be described in detail with reference to the drawings. In addition, this invention is not limited by these embodiments.
［第１実施形態］
　ここでは、第１実施形態について図１を参照して説明する。図１は第１実施形態の基本原理を示す原理構成図である。 [First embodiment]
Here, the first embodiment will be described with reference to FIG. FIG. 1 is a principle configuration diagram showing the basic principle of the first embodiment.
　まず、評価対象（例えば動物やヒトなどの個体）から採取した血液（例えば血漿や血清などを含む）中の前記１９種類のアミノ酸の濃度値、当該血液中の前記２５種類のアミノ酸関連代謝物の値（濃度値または面積値）、当該血液中の前記１３種類の検査項目の検査値、および当該評価対象の前記２種類の身体特徴の特徴値のうちの少なくとも１つの測定値に関する測定データを取得する（ステップＳ１１）。換言すると、前記１９種類のアミノ酸の濃度値、前記２５種類のアミノ酸関連代謝物の値、前記１３種類の検査項目の検査値、および前記２種類の身体特徴の特徴値を含む群から選択される少なくとも１つの測定値に関する測定データを取得する。なお、「測定値」は、濃度値、面積値、検査値、および特徴値の総称である。また、アミノ酸、アミノ酸関連代謝物、検査項目、および身体特徴を総称して「測定対象」と記載する場合がある。 First, concentration values of the 19 types of amino acids in blood (including plasma and serum, etc.) collected from an evaluation subject (for example, individuals such as animals and humans), and the 25 types of amino acid-related metabolites in the blood acquisition of measurement data related to at least one measurement value (concentration value or area value), the test values of the 13 types of test items in the blood, and the characteristic values of the two types of physical characteristics to be evaluated. (step S11). In other words, it is selected from the group including the concentration values of the 19 types of amino acids, the values of the 25 types of amino acid-related metabolites, the test values of the 13 types of test items, and the characteristic values of the 2 types of physical characteristics. Obtaining measurement data for at least one measurement. Note that "measured value" is a general term for density value, area value, inspection value, and feature value. In addition, amino acids, amino acid-related metabolites, test items, and physical characteristics may be collectively referred to as "measurement target".
　ここで、評価対象は、例えば、健常者、ＭＣＩを有するもの、または、検査などの何らかの手段によりＭＣＩである可能性が高いと評価されたもの、などでもよい。また、ＭＣＩを有する評価対象とは、例えば、ＭＣＩの既存の診断基準（例えば非特許文献４など）に基づきＭＣＩと診断されたものなどである。 Here, the subject to be evaluated may be, for example, a healthy subject, a subject with MCI, or a subject evaluated as likely to have MCI by some means such as testing. An evaluation subject with MCI is, for example, a subject diagnosed with MCI based on the existing diagnostic criteria for MCI (for example, Non-Patent Document 4, etc.).
　また、ステップＳ１１では、例えば、測定値の測定を行う企業等が測定した測定データを取得してもよい。また、評価対象から採取した血液から、例えば以下の（Ａ）、（Ｂ）、（Ｃ）、または（Ｄ）などの測定方法による測定を実施することで測定データを取得してもよい。ここで、濃度値の単位は、例えばモル濃度、重量濃度、または酵素活性であってもよく、これらの濃度に任意の定数を加減乗除することで得られるものでもよい。また、評価対象から採取した血液から、例えばＢＣＰ（bromocresol　purple）改良法、ＣＬＥＩＡ（chemiluminescent　enzyme　immuno　assay）法、半導体レーザーを使用したフローサイトメトリー法、シースフロー直流電流検出方式、ＳＬＳ（sodium　lauryl　sulfate）－ヘモグロビン法、または赤血球パルス波高値検出法などの測定方法による検査値の測定を実施することで、測定データを取得してもよい。
（Ａ）採取した血液サンプルを遠心することにより血液から血漿を分離する。全ての血漿サンプルは、濃度値の測定時まで－８０℃で凍結保存する。濃度値測定時には、アセトニトリルを添加し除蛋白処理を行った後、必要に応じて固層抽出等によりリン脂質等の夾雑物を除去し、標識試薬（３－アミノピリジル－Ｎ－ヒドロキシスクシンイミジルカルバメート）を用いてプレカラム誘導体化を行い、そして、液体クロマトグラフィー質量分析法（タンデム質量分析法を含む）により濃度値を分析する（国際公開第２００３／０６９３２８号、国際公開第２００５／１１６６２９号を参照）。
（Ｂ）採取した血液サンプルを遠心することにより血液から血漿を分離する。全ての血漿サンプルは、濃度値の測定時まで－８０℃で凍結保存する。濃度値測定時には、スルホサリチル酸を添加し除蛋白処理を行った後、ニンヒドリン試薬を用いたポストカラム誘導体化法を原理としたアミノ酸分析計により濃度値を分析する。
（Ｃ）採取した血液サンプルを、膜やＭＥＭＳ（Micro　Electro　Mechanical　Systems）技術または遠心分離の原理を用いて血球分離を行い、血液から血漿または血清を分離する。血漿または血清取得後すぐに濃度値の測定を行わない血漿または血清サンプルは、濃度値の測定時まで－８０℃で凍結保存する。濃度値測定時には、酵素やアプタマーなど、標的とする血中物質と反応または結合する分子等を用い、基質認識によって増減する物質や分光学的値を定量等することにより濃度値を分析する。
（Ｄ）採取した血漿サンプルに内標準混合溶液およびアセトニトリルを加えて混和した後、遠心分離する。得られた上清を乾固後、精製水にて再溶解し前処理後試料とする。この試料を液体クロマトグラフィー質量分析法（タンデム質量分析法を含む）にて定量する。定量にはピーク面積による内標準法を用いる。 Further, in step S11, for example, measurement data measured by a company or the like that measures the measurement values may be acquired. Alternatively, measurement data may be obtained by performing measurement using the following measurement methods (A), (B), (C), or (D) from blood collected from an evaluation subject. Here, the unit of the concentration value may be, for example, molar concentration, weight concentration, or enzyme activity, and may be obtained by adding, subtracting, multiplying, or dividing these concentrations by an arbitrary constant. Further, from the blood collected from the evaluation subject, for example, BCP (bromocresol purple) improved method, CLEIA (chemiluminescent enzyme immunoassay) method, flow cytometry method using a semiconductor laser, sheath flow direct current detection method, SLS (sodium lauryl sulfate )-Measurement data may be obtained by measuring test values by a measurement method such as the hemoglobin method or the red blood cell pulse peak value detection method.
(A) Plasma is separated from the blood by centrifuging the collected blood sample. All plasma samples are stored frozen at −80° C. until concentration values are measured. At the time of concentration value measurement, acetonitrile is added to remove proteins, and if necessary, contaminants such as phospholipids are removed by solid phase extraction, etc., and a labeling reagent (3-aminopyridyl-N-hydroxysuccinimide pre-column derivatization with dilucarbamate) and concentration values are analyzed by liquid chromatography mass spectrometry (including tandem mass spectrometry) (WO2003/069328, WO2005/116629 ).
(B) Separating the plasma from the blood by centrifuging the collected blood sample. All plasma samples are stored frozen at −80° C. until concentration values are measured. When measuring the concentration value, sulfosalicylic acid is added to deproteinize, and then the concentration value is analyzed with an amino acid analyzer based on the principle of the post-column derivatization method using a ninhydrin reagent.
(C) Blood cell separation is performed on the collected blood sample using a membrane, MEMS (Micro Electro Mechanical Systems) technology, or the principle of centrifugation to separate plasma or serum from the blood. Plasma or serum samples that are not subjected to concentration readings immediately after obtaining plasma or serum are stored frozen at -80°C until concentration readings are taken. At the time of concentration value measurement, molecules such as enzymes and aptamers that react with or bind to target blood substances are used, and concentration values are analyzed by quantifying substances and spectroscopic values that increase or decrease due to substrate recognition.
(D) An internal standard mixed solution and acetonitrile are added to the collected plasma sample, mixed, and then centrifuged. After the obtained supernatant is dried, it is redissolved in purified water to obtain a sample after pretreatment. This sample is quantified by liquid chromatography mass spectrometry (including tandem mass spectrometry). An internal standard method based on peak area is used for quantification.
　つぎに、ステップＳ１１で取得した測定データに含まれる測定値を用いて、評価対象について認知症（例えば、ＡＤ、ＤＬＢ、ＦＴＤ、またはＶａＤなど）の将来の発症リスクを評価する（ステップＳ１２）。なお、ステップＳ１２を実行する前に、ステップＳ１１で取得した測定データから欠損値および外れ値などのデータを除去してもよい。ここで、評価対象について認知症の将来の発症リスクを評価するとは、例えば、この評価対象が認知症を将来発症するリスクを予測または検査することである。また、将来とは、例えば、採血時から所定期間（例えば、医学分野において知られている「ＭＣＩからＡＤへ進行するまでにかかる平均的な期間」、または、例えば３年、４年、５年等といった年単位の期間、など）が経過した時、などである。 Next, using the measured values included in the measurement data acquired in step S11, the future risk of developing dementia (for example, AD, DLB, FTD, VaD, etc.) is evaluated for the evaluation target (step S12). Data such as missing values and outliers may be removed from the measurement data acquired in step S11 before executing step S12. Here, evaluating the risk of developing dementia in the future for an object to be evaluated means, for example, predicting or examining the risk of the object to be evaluated developing dementia in the future. In addition, the future is, for example, a predetermined period from the time of blood collection (for example, "average period from MCI to AD known in the medical field", or, for example, 3 years, 4 years, 5 years etc., when a period of years, etc.) has passed.
　以上、第１実施形態によれば、ステップＳ１１では評価対象の測定データを取得し、ステップＳ１２では、ステップＳ１１で取得した評価対象の測定データに含まれる測定値を用いて、評価対象について認知症の将来の発症リスクを評価する。これにより、認知症の将来の発症リスクを知る上で参考となり得る信頼性の高い情報を提供することができる。例えば、評価対象が、ＭＣＩを有するもの、または、検査などの何らかの手段によりＭＣＩである可能性が高いと評価されたものであった場合は、認知症の将来の発症リスクを知る上で参考となり得る信頼性の高い情報を、例えばＭＣＩという認知症発症の前段階で、例えば認知症発症予防を目的として提供することができる。また、本実施形態に係る評価方法は、マススクリーニングに適した簡便且つ安価な認知症発症リスク予測検査法として有用なものである。また、本実施形態に係る評価方法で得られた、認知症の将来の発症リスクの評価結果は、例えば、認知症疾患修飾薬（例えば、抗アミロイドβ抗体、抗アミロイドβプロトフィブリル抗体、抗タウ抗体、またはアミロイドβワクチンなど）の投与対象の判別（スクリーニング）に使うことができる。また、本実施形態に係る評価方法で得られた、認知症の将来の発症リスクの評価結果は、例えば、ＡＤ疾患修飾薬の治療効果予測に使うことができる（例えば、本実施形態に係る評価方法により将来の発症リスクが高いと評価された人に薬を投与した後、当該投与後の人を本実施形態に係る評価方法により再び評価した結果、将来の発症リスクが低くなっていたら、治療効果が出ていると言える可能性があると予測してもよい。）また、本実施形態に係る評価方法で得られた、認知症の将来の発症リスクの評価結果は、例えば、認知症の進行度の予測に使うことができる。 As described above, according to the first embodiment, in step S11, the measurement data of the evaluation target is acquired, and in step S12, the measurement value included in the measurement data of the evaluation target acquired in step S11 is used to determine whether the evaluation target has dementia. assess the risk of future development of As a result, it is possible to provide highly reliable information that can serve as a reference for knowing the risk of developing dementia in the future. For example, if the subject to be evaluated has MCI, or is evaluated to be highly likely to have MCI by some means such as testing, it will be helpful in knowing the risk of developing dementia in the future. Obtained highly reliable information can be provided, for example, in a stage prior to the onset of dementia called MCI, for the purpose of preventing the onset of dementia, for example. Moreover, the evaluation method according to the present embodiment is useful as a simple and inexpensive dementia onset risk prediction test method suitable for mass screening. Further, the evaluation results of the future risk of developing dementia obtained by the evaluation method according to the present embodiment are, for example, dementia disease-modifying drugs (e.g., anti-amyloid β antibody, anti-amyloid β protofibril antibody, anti-tau It can be used for discrimination (screening) of administration subjects of antibodies, amyloid β vaccines, etc. In addition, the evaluation result of the future risk of developing dementia obtained by the evaluation method according to the present embodiment can be used, for example, to predict the therapeutic effect of an AD disease-modifying drug (for example, the evaluation according to the present embodiment After administering the drug to a person who has been evaluated to have a high risk of future onset by the method, the person after the administration is re-evaluated by the evaluation method according to this embodiment, and if the risk of future onset is low, treatment It may be predicted that there is a possibility that it can be said to be effective.) In addition, the evaluation result of the future onset risk of dementia obtained by the evaluation method according to the present embodiment is, for example, dementia Can be used to predict progress.
　また、ステップＳ１２を実行する前に、評価対象から採取した生体サンプル（例えば血液、口腔スワブ、または毛髪等）を用いてＡｐｏＥ遺伝子を検査する検査ステップと、検査で得られたＡｐｏＥの遺伝型を基に、ＡＰＯＥアリルの保有に関するカテゴリカル変数の値を決定する決定ステップと、を実行し、ステップＳ１２では、測定値（具体的にはVal、Leu、およびIleの濃度値の合計）および当該決定した値を用いて、評価対象について認知症の将来の発症リスクを評価してもよい。なお、カテゴリカル変数の値として、ｉ）ＡＰＯＥε４アリルの有無に関する二値変数（ダミー変数）の値、ｉｉ）ＡＰＯＥ遺伝子型に含まれるＡＰＯＥε４アリルの個数の値（０個、１個、または２個）、または、ｉｉｉ）ＡＰＯＥ遺伝子に対する３種類のアイソフォームに基づくＡＰＯＥ遺伝子型の６つの分類（（ε２アリル，ε２アリル）、（ε３アリル，ε３アリル）、（ε４アリル，ε４アリル）、（ε２アリル，ε３アリル）、（ε２アリル，ε４アリル）、および（ε３アリル，ε４アリル））のそれぞれに割り当てた値、を使用してもよい。 Further, before executing step S12, a test step of testing the ApoE gene using a biological sample (for example, blood, oral swab, or hair) collected from the subject to be evaluated, and determining the ApoE genotype obtained by the test. a determination step of determining the value of a categorical variable related to APOE allele possession, and in step S12, the measured value (specifically the sum of the concentration values of Val, Leu, and Ile) and the determination You may evaluate the future onset risk of dementia about an evaluation object using the calculated value. The values of the categorical variables include i) the value of a binary variable (dummy variable) regarding the presence or absence of the APOE ε4 allele, ii) the value of the number of APOE ε4 alleles contained in the APOE genotype (0, 1, or 2). ), or iii) six classes of APOE genotypes based on three isoforms for the APOE gene ((ε2 allyl, ε2 allyl), (ε3 allyl, ε3 allyl), (ε4 allyl, ε4 allyl), (ε2 The values assigned to each of (ε2 allyl, ε3 allyl), (ε2 allyl, ε4 allyl), and (ε3 allyl, ε4 allyl)) may be used.
　また、ステップＳ１１を実行する前に、前記検査ステップと、検査で得られたＡｐｏＥの遺伝型を基にＡＰＯＥε４アリルを保有しているか否か確認する確認ステップと、を実行し、ステップＳ１１では、ＡＰＯＥε４アリルを保有しない評価対象から採取した血液を用いて測定データを取得し、ステップＳ１２では、当該取得した測定データに含まれる測定値（具体的にはAla、Arg、Asn、Cit、Gln、Gly、His、Ile、Leu、Lys、Met、Orn、Phe、Pro、Ser、Thr、Trp、Tyr、およびValの濃度値ならびにVal、Leu、およびIleの濃度値の合計のうちの少なくとも１つの値）を用いて、評価対象について認知症の将来の発症リスクを評価してもよい。 Also, before executing step S11, the test step and a confirmation step of confirming whether or not the subject has the APOE ε4 allele based on the ApoE genotype obtained by the test are executed, and in step S11, Measurement data is obtained using blood collected from an evaluation subject that does not possess the APOE ε4 allele, and in step S12, measurement values included in the obtained measurement data (specifically, Ala, Arg, Asn, Cit, Gln, Gly , His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, and Val concentration values and at least one of the sum of Val, Leu, and Ile concentration values) may be used to assess the future risk of developing dementia for the subject.
　また、測定値が評価対象についての認知症の将来の発症リスクを反映したものであると決定してもよく、さらに測定値を例えば以下に挙げた手法などで変換し、変換後の値が評価対象についての認知症の将来の発症リスクを反映したものであると決定してもよい。換言すると、測定値または当該測定値の変換後の値そのものを、評価対象についての認知症の将来の発症リスクに関する評価結果として扱ってもよい。
　測定値の取り得る範囲が所定範囲（例えば０．０から１．０までの範囲、０．０から１０．０までの範囲、０．０から１００．０までの範囲、または－１０．０から１０．０までの範囲、など）に収まるようにする等のために、例えば、測定値に対して任意の値を加減乗除したり、測定値を所定の変換手法（例えば、指数変換、対数変換、角変換、平方根変換、プロビット変換、逆数変換、Ｂｏｘ－Ｃｏｘ変換、またはべき乗変換など）で変換したり、また、測定値に対してこれらの計算を組み合わせて行ったりすることで、測定値を変換してもよい。例えば、測定値を指数としネイピア数を底とする指数関数の値（具体的には、認知症の将来の発症リスクが所定の状態（例えば高リスクの状態など）である確率ｐを定義したときの自然対数ｌｎ（ｐ／（１－ｐ））が測定値と等しいとした場合におけるｐ／（１－ｐ）の値）をさらに算出してもよく、また、算出した指数関数の値を１と当該値との和で割った値（具体的には、確率ｐの値）をさらに算出してもよい。
　また、特定の条件のときの変換後の値が特定の値となるように、測定値を変換してもよい。例えば、特異度が６０％のときの変換後の値が５．０となり且つ特異度が９０％のときの変換後の値が８．０となるように測定値を変換してもよく、特異度が８０％のときの変換後の値が５．０となり且つ特異度が９５％のときの変換後の値が８．０となるように測定値を変換してもよい。
　また、測定値の分布を正規分布化し、その正規分布を基に平均が５０で且つ標準偏差が１０となるように測定値の偏差値化を行うという処理を、測定対象ごとに行ってもよい。
　また、上述した各種の変換は、男女別または年齢別に行ってもよい。
　また、本明細書における測定値は、測定値そのものであってもよく、測定値を変換した後の数値であってもよい。 In addition, it may be determined that the measured value reflects the future risk of developing dementia for the evaluation subject, and the measured value is converted, for example, by the following methods, and the converted value is evaluated It may be determined to reflect the future risk of developing dementia for the subject. In other words, the measured value or the converted value of the measured value itself may be treated as the evaluation result regarding the future risk of developing dementia for the evaluation target.
The range that the measured value can take is a predetermined range (for example, the range from 0.0 to 1.0, the range from 0.0 to 10.0, the range from 0.0 to 100.0, or from -10.0 10.0 range, etc.), for example, adding, subtracting, multiplying, or dividing the measured value by an arbitrary value, or converting the measured value to a predetermined conversion method (e.g., exponential conversion, logarithmic conversion , angle transform, square root transform, probit transform, reciprocal transform, Box-Cox transform, or exponentiation), or by performing a combination of these calculations on the measured value may be converted. For example, the value of the exponential function with the measured value as the index and the Napier number as the base (specifically, the probability p that the future risk of developing dementia is in a predetermined state (such as a high-risk state) is defined The value of p/(1-p) when the natural logarithm ln (p/(1-p)) is equal to the measured value) may be further calculated, and the value of the calculated exponential function is set to 1 and the value (specifically, the value of the probability p) may be further calculated.
Also, the measured value may be converted so that the value after conversion under a specific condition becomes a specific value. For example, the measured value may be converted so that the converted value is 5.0 when the specificity is 60% and the converted value is 8.0 when the specificity is 90%. The measured values may be transformed so that the transformed value is 5.0 when the degree is 80% and the transformed value is 8.0 when the specificity is 95%.
In addition, a process of normalizing the distribution of the measured values and converting the measured values into deviation values so that the average is 50 and the standard deviation is 10 based on the normal distribution may be performed for each measurement object. .
Also, the various conversions described above may be performed by gender or by age.
Moreover, the measured value in this specification may be the measured value itself, or may be a numerical value after converting the measured value.
　また、測定値を例えば上述した変換手法で変換した後の値を用いて、評価対象について認知症の将来の発症リスクを評価してもよい。 In addition, the future risk of developing dementia may be evaluated for the evaluation target using the values after the measured values are converted, for example, by the conversion method described above.
　また、モニタ等の表示装置または紙等の物理媒体に視認可能に示される所定の物差し上における所定の目印の位置に関する位置情報を、測定値または当該測定値を変換した場合にはその変換後の値を用いて生成し、生成した位置情報が評価対象についての認知症の将来の発症リスクを反映したものであると決定してもよい。なお、所定の物差しとは、認知症の将来の発症リスクを評価するためのものであり、例えば、目盛りが示された物差しであって、「測定値または変換後の値の取り得る範囲、または、当該範囲の一部分」における上限値と下限値に対応する目盛りが少なくとも示されたもの、などである。また、所定の目印とは、測定値または変換後の値に対応するものであり、例えば、丸印または星印などである。 In addition, position information regarding the position of a predetermined mark on a predetermined ruler that is visibly displayed on a display device such as a monitor or on a physical medium such as paper is a measured value or, if the measured value is converted, the converted value It may be determined that the generated location information reflects the future risk of developing dementia for the subject of evaluation. In addition, the predetermined ruler is for evaluating the risk of future development of dementia, for example, a ruler with a scale, "the possible range of the measured value or the value after conversion, or , at least scales corresponding to the upper and lower limits of "a portion of the range" are indicated. A predetermined mark corresponds to a measured value or a converted value, and is, for example, a circle mark or a star mark.
　また、測定値が、所定値（平均値±１ＳＤ、２ＳＤ、３ＳＤ、Ｎ分位点、Ｎパーセンタイル、または臨床的意義の認められたカットオフ値など）より低いもしくは所定値以下の場合または所定値以上もしくは所定値より高い場合に、評価対象について認知症の将来の発症リスクを評価してもよい。その際、測定値そのものではなく、偏差値（測定対象ごとに、男女別に測定値の分布を正規分布化した後、その正規分布を基に平均が５０で且つ標準偏差が１０となるように測定値の偏差値化を行って得られた値）を用いてもよい。例えば、偏差値が平均値－２ＳＤ未満の場合（偏差値＜３０の場合）または偏差値が平均値＋２ＳＤより高い場合（偏差値＞７０の場合）に、評価対象について認知症の将来の発症リスクを評価してもよい。 In addition, if the measured value is lower than or below a predetermined value (mean ± 1SD, 2SD, 3SD, N quantile, N percentile, or clinically significant cutoff value, etc.) or a predetermined value If it is higher than or equal to or higher than a predetermined value, the risk of developing dementia in the future may be evaluated for the evaluation target. At that time, instead of the measured value itself, the deviation value (after normalizing the distribution of the measured values by gender for each measurement object, measure so that the average is 50 and the standard deviation is 10 based on the normal distribution. A value obtained by converting the value into a deviation value) may be used. For example, if the deviation value is less than the mean value -2SD (deviation value <30) or if the deviation value is higher than the mean +2SD (deviation value >70), the future onset risk of dementia for the evaluation target may be evaluated.
　また、測定値が代入される変数を含む式および測定値を用いて式の値を算出することで、評価対象について認知症の将来の発症リスクを評価してもよい。具体的には、認知症の将来の発症リスクを評価するための式に含まれる変数に測定値を代入して式の値を算出することで、評価対象について認知症の将来の発症リスクを評価してもよい。 In addition, the risk of future onset of dementia may be evaluated for the evaluation target by calculating the value of the formula using the formula and the measured values that include the variables into which the measured values are substituted. Specifically, by substituting measured values into the variables included in the formula for evaluating the future risk of developing dementia and calculating the value of the formula, the future risk of developing dementia is evaluated for the evaluation target. You may
　また、ステップＳ１２を実行する前に、前記検査ステップと前記決定ステップとを実行し、ステップＳ１２では、測定値（具体的にはVal、Leu、およびIleの濃度値の合計）が代入される変数と前記決定ステップで決定した値が代入される変数とを含む式、当該測定値、および当該決定した値を用いて式の値を算出することで、評価対象について認知症の将来の発症リスクを評価してもよい。 Also, before executing step S12, the inspection step and the determination step are executed, and in step S12, the variable and a variable to which the value determined in the determination step is substituted, the measured value, and the determined value are used to calculate the value of the formula, thereby determining the risk of future onset of dementia for the evaluation subject. may be evaluated.
　また、ステップＳ１１を実行する前に、前記検査ステップと前記確認ステップとを実行し、ステップＳ１１では、ＡＰＯＥε４アリルを保有しない評価対象から採取した血液を用いて測定データを取得し、ステップＳ１２では、当該取得した測定データに含まれる測定値（具体的にはAla、Arg、Asn、Cit、Gln、Gly、His、Ile、Leu、Lys、Met、Orn、Phe、Pro、Ser、Thr、Trp、Tyr、およびValの濃度値ならびにVal、Leu、およびIleの濃度値の合計のうちの少なくとも１つの値）を用いて、評価対象について認知症の将来の発症リスクを評価してもよい。 Also, before executing step S11, the test step and the confirmation step are executed, and in step S11, measurement data is obtained using blood collected from an evaluation subject that does not possess the APOE ε4 allele, and in step S12, Measurement values included in the acquired measurement data (specifically, Ala, Arg, Asn, Cit, Gln, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr , and at least one of the concentration values of Val and the sum of the concentration values of Val, Leu, and Ile) may be used to evaluate the risk of developing dementia in the future for the subject.
　また、算出した式の値が評価対象についての認知症の将来の発症リスクを反映したものであると決定してもよく、さらに式の値を例えば以下に挙げた手法などで変換し、変換後の数値が評価対象についての認知症の将来の発症リスクを反映したものであると決定してもよい。換言すると、式の値または当該式の値の変換後の値そのものを、評価対象についての認知症の将来の発症リスクに関する評価結果として扱ってもよい。
　式の値の取り得る範囲が所定範囲（例えば０．０から１．０までの範囲、０．０から１０．０までの範囲、０．０から１００．０までの範囲、または－１０．０から１０．０までの範囲、など）に収まるようにする等のために、例えば、式の値に対して任意の値を加減乗除したり、式の値を所定の変換手法（例えば、指数変換、対数変換、角変換、平方根変換、プロビット変換、逆数変換、Ｂｏｘ－Ｃｏｘ変換、またはべき乗変換など）で変換したり、また、式の値に対してこれらの計算を組み合わせて行ったりすることで、式の値を変換してもよい。例えば、式の値を指数としネイピア数を底とする指数関数の値（具体的には、認知症の将来の発症リスクが所定の状態（例えば高リスクの状態など）である確率ｐを定義したときの自然対数ｌｎ（ｐ／（１－ｐ））が式の値と等しいとした場合におけるｐ／（１－ｐ）の値）をさらに算出してもよく、また、算出した指数関数の値を１と当該値との和で割った値（具体的には、確率ｐの値）をさらに算出してもよい。
　また、特定の条件のときの変換後の値が特定の値となるように、式の値を変換してもよい。例えば、特異度が６０％のときの変換後の値が５．０となり且つ特異度が９０％のときの変換後の値が８．０となるように式の値を変換してもよく、特異度が８０％のときの変換後の値が５．０となり且つ特異度が９５％のときの変換後の値が８．０となるように式の値を変換してもよい。
　また、平均が５０で且つ標準偏差が１０となるように式の値の偏差値化を行ってもよい。
　また、上述した各種の変換は、男女別または年齢別に行ってもよい。
　また、本明細書における式の値は、式の値そのものであってもよく、式の値を変換した後の値であってもよい。 In addition, it may be determined that the value of the calculated formula reflects the future risk of developing dementia for the evaluation subject, and the value of the formula is converted, for example, by the following methods, and after conversion It may be determined that the value of reflects the future risk of developing dementia for the subject being evaluated. In other words, the value of the formula or the converted value of the formula itself may be treated as the evaluation result regarding the future risk of developing dementia for the subject of evaluation.
If the range of possible values of the expression is a predetermined range (for example, the range from 0.0 to 1.0, the range from 0.0 to 10.0, the range from 0.0 to 100.0, or -10.0 to 10.0, etc.), for example, adding, subtracting, multiplying, or dividing the value of the expression by an arbitrary value, or converting the value of the expression to a predetermined conversion method (e.g., exponential conversion , logarithmic transformation, angle transformation, square root transformation, probit transformation, inverse transformation, Box-Cox transformation, or power transformation), or by combining these calculations on the value of the expression , may transform the value of the expression. For example, the value of the exponential function with the value of the formula as the index and the Napier number as the base (specifically, the probability p that the future risk of developing dementia is in a predetermined state (such as a high-risk state) was defined The value of p / (1-p) when the natural logarithm ln (p / (1-p)) is equal to the value of the formula) may be further calculated, and the calculated value of the exponential function may be further calculated by dividing by the sum of 1 and the value (specifically, the value of probability p).
Alternatively, the value of the expression may be converted so that the value after conversion under a specific condition becomes a specific value. For example, the value of the formula may be converted so that the converted value is 5.0 when the specificity is 60% and the converted value is 8.0 when the specificity is 90%, The value of the formula may be transformed so that the transformed value is 5.0 when the specificity is 80% and the transformed value is 8.0 when the specificity is 95%.
Also, the values in the formula may be converted into deviation values so that the average is 50 and the standard deviation is 10.
Also, the various conversions described above may be performed by gender or by age.
Further, the value of the formula in this specification may be the value of the formula itself, or may be the value after converting the value of the formula.
　また、モニタ等の表示装置または紙等の物理媒体に視認可能に示される所定の物差し上における所定の目印の位置に関する位置情報を、式の値または当該式の値を変換した場合にはその変換後の値を用いて生成し、生成した位置情報が評価対象についての認知症の将来の発症リスクを反映したものであると決定してもよい。なお、所定の物差しとは、認知症の将来の発症リスクを評価するためのものであり、例えば、目盛りが示された物差しであって、「式の値または変換後の値の取り得る範囲、または、当該範囲の一部分」における上限値と下限値に対応する目盛りが少なくとも示されたもの、などである。また、所定の目印とは、式の値または変換後の値に対応するものであり、例えば、丸印または星印などである。 In addition, the position information regarding the position of a predetermined mark on a predetermined ruler visibly displayed on a display device such as a monitor or on a physical medium such as paper is the value of the formula or, if the value of the formula is converted, the conversion It may be generated using the later values and determined that the generated location information reflects the future risk of developing dementia for the subject. The predetermined ruler is for evaluating the risk of developing dementia in the future. Alternatively, at least scales corresponding to the upper and lower limits of "part of the range" are indicated. Further, the predetermined mark corresponds to the value of the formula or the value after conversion, and is, for example, a circle mark or an asterisk.
　また、評価対象が認知症を将来発症するリスク（可能性）の程度を定性的に評価してもよい。具体的には、「測定値および予め設定された１つまたは複数の閾値」または「測定値、測定値が代入される変数を含む式、および予め設定された１つまたは複数の閾値」を用いて、評価対象を、認知症の将来の発症リスクの程度を少なくとも考慮して定義された複数の区分のうちのどれか１つの区分に分類してもよい。なお、複数の区分には、認知症の将来の発症リスクが高い対象を属させるための区分、認知症の将来の発症リスクが低い対象を属させるための区分、および認知症の将来の発症リスクが中程度である対象を属させるための区分が含まれていてもよい。また、複数の区分には、認知症の将来の発症リスクが高い対象を属させるための区分および認知症の将来の発症リスクが低い対象を属させるための区分が含まれていてもよい。また、測定値または式の値を所定の手法で変換し、変換後の値を用いて評価対象を複数の区分のうちのどれか１つの区分に分類してもよい。 In addition, the degree of risk (possibility) for the subject to develop dementia in the future may be qualitatively evaluated. Specifically, using "measured value and one or more preset thresholds" or "measured value, an expression containing a variable into which the measured value is substituted, and one or more preset thresholds" Therefore, the subject of evaluation may be classified into any one of a plurality of categories defined by at least considering the degree of risk of developing dementia in the future. The multiple categories include a category for assigning subjects with a high risk of developing dementia in the future, a category for assigning subjects with a low risk of developing dementia in the future, and a category for assigning subjects with a low risk of developing dementia in the future. A segment may be included to attribute subjects with moderate . In addition, the plurality of categories may include a category for assigning subjects with a high risk of developing dementia in the future and a category for assigning subjects with a low risk of developing dementia in the future. Alternatively, the measured value or the value of the formula may be converted by a predetermined method, and the converted value may be used to classify the evaluation object into one of a plurality of categories.
　また、評価の際に用いる式について、その形式は特に問わないが、例えば、以下に示す形式のものでもよい。
・最小二乗法に基づく重回帰式、線形判別式、主成分分析、正準判別分析などの線形モデル
・最尤法に基づくロジスティック回帰、Ｃｏｘ回帰などの一般化線形モデル
・一般化線形モデルに加えて個体間差、施設間差などの変量効果を考慮した一般化線形混合モデル
・Ｋ－ｍｅａｎｓ法、階層的クラスター解析などクラスター解析で作成された式
・ＭＣＭＣ(マルコフ連鎖モンテカルロ法)、ベイジアンネットワーク、階層ベイズ法などベイズ統計に基づき作成された式
・サポートベクターマシンや決定木などクラス分類により作成された式
・分数式など上記のカテゴリに属さない手法により作成された式
・異なる形式の式の和で示されるような式 The formula used for evaluation is not particularly limited in form, but may be of the form shown below, for example.
・Linear models such as multiple regression equations, linear discriminants, principal component analysis, and canonical discriminant analysis based on the least squares method ・Generalized linear models such as logistic regression and Cox regression based on the maximum likelihood method ・In addition to generalized linear models Generalized linear mixed model considering random effects such as inter-individual differences and inter-institutional differences ・ Formulas created by cluster analysis such as K-means method and hierarchical cluster analysis ・ MCMC (Markov chain Monte Carlo method), Bayesian network, Formulas created based on Bayesian statistics such as hierarchical Bayesian formulas Formulas created by class classification such as support vector machines and decision trees Formulas created by methods that do not belong to the above categories such as fractional formulas Sum of formulas in different formats An expression such as
　また、評価の際に用いる式を、例えば、本出願人による国際出願である国際公開第２００４／０５２１９１号に記載の方法または本出願人による国際出願である国際公開第２００６／０９８１９２号に記載の方法で作成してもよい。なお、これらの方法で得られた式であれば、測定値の単位に因らず、当該式を認知症の将来の発症リスクを評価するのに好適に用いることができる。 Further, the formula used in the evaluation may be, for example, the method described in International Publication No. WO 2004/052191 by the applicant or the method described in International Publication No. WO 2006/098192 by the applicant. method can be created. It should be noted that the formulas obtained by these methods can be suitably used for evaluating the future risk of developing dementia regardless of the units of the measured values.
　ここで、重回帰式、多重ロジスティック回帰式、正準判別関数などにおいては各変数に係数および定数項が付加されるが、この係数および定数項は、好ましくは実数であれば構わず、より好ましくは、データから前記各種分類を行うために得られた係数および定数項の９９％信頼区間の範囲に属する値であれば構わず、さらに好ましくは、データから前記各種分類を行うために得られた係数および定数項の９５％信頼区間の範囲に属する値であれば構わない。また、各係数の値およびその信頼区間はそれを実数倍したものでもよく、定数項の値およびその信頼区間はそれに任意の実定数を加減乗除したものでもよい。ロジスティック回帰式、線形判別式、重回帰式などを評価の際に用いる場合、線形変換（定数の加算、定数倍）および単調増加（減少）の変換（例えばｌｏｇｉｔ変換など）は式の評価性能を変えるものではなく、変換後の式の評価性能は変換前のものと同等であるので、変換後の式を評価の際に用いてもよい。 Here, in multiple regression equations, multiple logistic regression equations, canonical discriminant functions, etc., coefficients and constant terms are added to each variable, and these coefficients and constant terms are preferably real numbers, more preferably is any value that belongs to the range of the 99% confidence interval of the coefficient and constant term obtained for performing the various classifications from the data, and more preferably, the value obtained for performing the various classifications from the data Any value within the 95% confidence interval of the coefficient and the constant term will do. Also, the value of each coefficient and its confidence interval may be obtained by multiplying it by a real number, and the value of the constant term and its confidence interval may be obtained by adding, subtracting, multiplying, or dividing it by an arbitrary real constant. When using logistic regression, linear discriminant, multiple regression, etc. in the evaluation, linear transformation (addition of constant, constant multiplication) and monotonically increasing (decreasing) transformation (e.g. logit transformation) reduce the evaluation performance of the equation. Since the evaluation performance of the expression after conversion is equivalent to that before conversion, the expression after conversion may be used for evaluation.
　また、分数式とは、当該分数式の分子が変数Ａ，Ｂ，Ｃ，・・・の和で表わされ、および／または、当該分数式の分母が変数ａ，ｂ，ｃ，・・・の和で表わされるものである。また、分数式には、このような構成の分数式α，β，γ，・・・の和（例えばα＋βのようなもの）も含まれる。また、分数式には、分割された分数式も含まれる。なお、分子や分母に用いられる変数には、それぞれ適当な係数がついても構わない。また、分子や分母に用いられる変数は、重複しても構わない。また、各分数式に適当な係数がついても構わない。また、各変数の係数の値や定数項の値は、実数であれば構わない。また、ある分数式と、当該ある分数式において分子の変数と分母の変数が入れ替えられた後の分数式（「入れ替え後の分数式」）とでは、目的変数との相関の正負の符号が概して逆転するものの、目的変数との相関性は保たれるが故に式の評価性能も同等と見做せるので、分数式には、当該入れ替え後の分数式も含まれる。 Further, a fractional expression is such that the numerator of the fractional expression is represented by the sum of variables A, B, C, . is represented by the sum of Fractional expressions also include the sum of fractional expressions α, β, γ, . Fractional expressions also include divided fractional expressions. It should be noted that the variables used for the numerator and denominator may each have appropriate coefficients. Also, the variables used for the numerator and denominator may overlap. Also, each fractional expression may have an appropriate coefficient. Also, the coefficient values and constant term values of each variable may be real numbers. In addition, between a certain fractional expression and a fractional expression in which the numerator variable and the denominator variable have been exchanged (“swapped fractional expression”), the positive or negative sign of the correlation with the objective variable is generally Although it is reversed, since the correlation with the objective variable is maintained, the evaluation performance of the formula can be considered to be the same, so the fractional formula includes the fractional formula after the replacement.
　そして、認知症の将来の発症リスクを評価する際、測定値以外に、以下に挙げる他の生体情報に関する値をさらに用いてもよい。また、評価の際に用いる式には、測定値が代入される変数以外に、以下に挙げる他の生体情報に関する値が代入される１つまたは複数の変数がさらに含まれてもよい。
１．アミノ酸およびアミノ酸関連代謝物以外の他の血中の代謝物（糖類・脂質等）、タンパク質、ペプチド、ミネラル、ビタミン、有機酸、ホルモン等の濃度値
２．総蛋白、糖化アルブミン、インスリン抵抗性指数、総コレステロール、ＨＤＬコレステロール、アミラーゼ、総ビリルビン、クレアチニン、推算糸球体濾過量(ｅＧＦＲ)、ＧＯＴ（ＡＳＴ）、ＧＰＴ（ＡＬＴ）、グルコース（血糖値）、ＭＣＶ、ＭＣＨ、ＭＣＨＣ、血小板数、インスリン、尿素窒素、カルシウム、血清鉄等の血液検査値
３．超音波エコー、Ｘ線、ＣＴ、ＭＲＩ、内視鏡像等の画像情報から得られる値
４．年齢、身長、腹囲、収縮期血圧、拡張期血圧、性別、喫煙情報、食事情報、飲酒情報、運動情報、ストレス情報、睡眠情報、家族の既往歴情報、疾患歴情報（糖尿病等）、身体能力情報（歩行速度、握力等）等の生体指標に関する値
５．アルツハイマー型認知症のリスク遺伝子（ＡＰＯＥε４アリル等）の保有数等の、生体サンプル（例えば血液、口腔スワブ、または毛髪等）中の遺伝子情報から得られる値
６．神経心理検査（ＭＭＳＥ（Ｍｉｎｉ－Ｍｅｎｔａｌ　Ｓｔａｔｅ　Ｅｘａｍｉｎａｔｉｏｎ）、ＭｏＣＡ（Ｍｏｎｔｒｅａｌ　Ｃｏｇｎｉｔｉｖｅ　Ａｓｓｅｓｓｍｅｎｔ）、ＦＡＢ（Ｆｒｏｎｔａｌ　Ａｓｓｅｓｓｍｅｎｔ　Ｂａｔｔｅｒｙ）、ＨＤＳ－Ｒ（改訂　長谷川式簡易知能評価スケール）、ＷＡＩＳＴＭ（ウェクスラー成人知能検査）、ＷＭＳＴＭ－Ｒ（ウェクスラー記憶検査　改訂版）、ＣＤＲ（臨床的認知症尺度）、ＡＤＡＭＳ－Ｃｏｇ（Alzheimer's　Disease　Assessment　Scale-cognitive　subscale）、ＧＤＳ（Ｇｅｒｉｔａｒｉｃ　Ｄｅｐｒｅｓｓｉｏｎ　Ｓｃａｌｅ（老年期うつ病評価尺度））等）により検査結果として得られる値。 Then, when evaluating the risk of developing dementia in the future, in addition to the measured values, values related to other biological information listed below may be further used. In addition, the formula used for evaluation may further include one or more variables into which values related to other biometric information listed below are substituted, in addition to variables into which measured values are substituted.
1. Concentration values of blood metabolites other than amino acids and amino acid-related metabolites (sugars, lipids, etc.), proteins, peptides, minerals, vitamins, organic acids, hormones, etc.2. Total protein, glycated albumin, insulin resistance index, total cholesterol, HDL cholesterol, amylase, total bilirubin, creatinine, estimated glomerular filtration rate (eGFR), GOT (AST), GPT (ALT), glucose (blood sugar level), MCV , MCH, MCHC, platelet count, insulin, urea nitrogen, calcium, serum iron, etc. 3. Values obtained from image information such as ultrasonic echoes, X-rays, CT, MRI, and endoscopic images;4. Age, height, waist circumference, systolic blood pressure, diastolic blood pressure, gender, smoking information, diet information, drinking information, exercise information, stress information, sleep information, family history information, disease history information (diabetes, etc.), physical ability 5. Values related to biomarkers such as information (walking speed, grip strength, etc.); Values obtained from genetic information in biological samples (eg, blood, oral swabs, hair, etc.), such as the number of carriers of Alzheimer's disease risk genes (APOE ε4 allele, etc.)6. Neuropsychological tests (MMSE (Mini-Mental State Examination), MoCA (Montreal Cognitive Assessment), FAB (Frontal Assessment Battery), HDS-R (Revised Hasegawa Simple Intelligence Scale), WAIS TM (Wechsler Adult Intelligence Scale), WMS TM -R (Wechsler memory test revised edition), CDR (clinical dementia scale), ADAMS-Cog (Alzheimer's Disease Assessment Scale-cognitive subscale), GDS (Geritaric Depression Scale (geriatric depression scale))), etc.) A value obtained as an inspection result.
［第２実施形態］
［２－１．第２実施形態の概要］
　ここでは、第２実施形態の概要について図２を参照して説明する。図２は第２実施形態の基本原理を示す原理構成図である。なお、本第２実施形態の説明では、上述した第１実施形態と重複する説明を省略する場合がある。特に、ここでは、認知症の将来の発症リスクを評価する際に、式の値またはその変換後の値を用いるケースを一例として記載しているが、例えば、測定値またはその変換後の値（例えば偏差値など）を用いてもよい。 [Second embodiment]
[2-1. Overview of Second Embodiment]
Here, an overview of the second embodiment will be described with reference to FIG. FIG. 2 is a principle configuration diagram showing the basic principle of the second embodiment. In addition, in the description of the second embodiment, the description that overlaps with the above-described first embodiment may be omitted. In particular, here, when evaluating the risk of developing dementia in the future, the case of using the value of the formula or its converted value is described as an example, but for example, the measured value or its converted value ( For example, a deviation value, etc.) may be used.
　制御部は、評価対象の予め取得した測定データに含まれる測定値および当該測定値が代入される変数を含む予め記憶部に記憶された式を用いて、式の値を算出することで、評価対象について認知症の将来の発症リスクを評価する（ステップＳ２１）。これにより、認知症の将来の発症リスクを知る上で参考となり得る信頼性の高い情報を提供することができる。例えば、評価対象が、ＭＣＩを有するもの、または、検査などの何らかの手段によりＭＣＩである可能性が高いと評価されたものであった場合は、認知症の将来の発症リスクを知る上で参考となり得る信頼性の高い情報を、例えばＭＣＩという認知症発症の前段階で、例えば認知症発症予防を目的として提供することができる。 The control unit calculates the value of the expression using the expression stored in the storage unit in advance, which includes the measured values included in the measurement data to be evaluated and the variables into which the measured values are substituted. A subject is evaluated for future risk of developing dementia (step S21). As a result, it is possible to provide highly reliable information that can serve as a reference for knowing the risk of developing dementia in the future. For example, if the subject to be evaluated has MCI, or is evaluated to be highly likely to have MCI by some means such as testing, it will be helpful in knowing the risk of developing dementia in the future. Obtained highly reliable information can be provided, for example, in a stage prior to the onset of dementia called MCI, for the purpose of preventing the onset of dementia, for example.
　なお、ステップＳ２１で用いられる式は、以下に説明する式作成処理（工程１～工程４）に基づいて作成されたものでもよい。ここで、式作成処理の概要について説明する。なお、ここで説明する処理はあくまでも一例であり、式の作成方法はこれに限定されない。 The formula used in step S21 may be created based on the formula creation process (steps 1 to 4) described below. Here, an outline of the formula creating process will be described. It should be noted that the processing described here is merely an example, and the method of creating an expression is not limited to this.
　まず、制御部は、予め記憶部に記憶された指標状態情報（欠損値や外れ値などを持つデータが事前に除去されているものでもよい）から所定の式作成手法に基づいて、候補式（例えば、ｙ＝ａ１ｘ１＋ａ２ｘ２＋・・・＋ａｎｘｎ、ｙ：指標データ、ｘｉ：測定データ、ａｉ：定数、ｉ＝１，２，・・・，ｎ）を作成する（工程１）。なお、指標状態情報は、測定データと、認知症の将来の発症リスクに関する指標データ（例えば、２値データなど）と、を含むものである。 First, the control unit generates a candidate formula ( For example, y=a1x1+a2x2+ . . . +anxn, y: index data, xi: measurement data, ai: constant, i=1, 2, . Note that the index state information includes measurement data and index data (for example, binary data) regarding the risk of developing dementia in the future.
　なお、工程１において、指標状態情報から、複数の異なる式作成手法（主成分分析や判別分析、サポートベクターマシン、重回帰分析、Ｃｏｘ回帰分析、ロジスティック回帰分析、ｋ－ｍｅａｎｓ法、クラスター解析、決定木などの多変量解析に関するものを含む。）を併用して複数の候補式を作成してもよい。具体的には、認知症ではない多数の者（例えば健常者またはＭＣＩを有する患者など）から得た血液を分析して得た測定データおよび指標データから構成される多変量データである指標状態情報に対して、複数の異なるアルゴリズムを利用して複数群の候補式を同時並行的に作成してもよい。例えば、異なるアルゴリズムを利用して判別分析およびロジスティック回帰分析を同時に行い、２つの異なる候補式を作成してもよい。また、主成分分析を行って作成した候補式を利用して指標状態情報を変換し、変換した指標状態情報に対して判別分析を行うことで候補式を作成してもよい。これにより、最終的に、評価に最適な式を作成することができる。 In step 1, a plurality of different formula creation methods (principal component analysis, discriminant analysis, support vector machine, multiple regression analysis, Cox regression analysis, logistic regression analysis, k-means method, cluster analysis, decision (including those related to multivariate analysis such as trees)) may be used together to create a plurality of candidate formulas. Specifically, index status information, which is multivariate data composed of measurement data and index data obtained by analyzing blood obtained from a large number of people without dementia (for example, healthy subjects or patients with MCI) , a plurality of groups of candidate formulas may be generated concurrently using a plurality of different algorithms. For example, discriminant analysis and logistic regression analysis may be performed simultaneously using different algorithms to generate two different candidate formulas. Alternatively, a candidate formula may be generated by converting the index state information using a candidate formula created by performing principal component analysis and performing discriminant analysis on the converted index state information. As a result, it is possible to finally create an optimal expression for evaluation.
　ここで、主成分分析を用いて作成した候補式は、全ての測定データの分散を最大にするような各変数を含む一次式である。また、判別分析を用いて作成した候補式は、各群内の分散の和の全ての測定データの分散に対する比を最小にするような各変数を含む高次式（指数や対数を含む）である。また、サポートベクターマシンを用いて作成した候補式は、群間の境界を最大にするような各変数を含む高次式（カーネル関数を含む）である。また、重回帰分析を用いて作成した候補式は、全ての測定データからの距離の和を最小にするような各変数を含む高次式である。また、Ｃｏｘ回帰分析を用いて作成した候補式は、対数ハザード比を含む線形モデルで、そのモデルの尤度を最大とするような各変数とその係数を含む一次式である。また、ロジスティック回帰分析を用いて作成した候補式は、確率の対数オッズを表す線形モデルであり、その確率の尤度を最大にするような各変数を含む一次式である。また、ｋ－ｍｅａｎｓ法とは、各測定データのｋ個近傍を探索し、近傍点の属する群の中で一番多いものをそのデータの所属群と定義し、入力された測定データの属する群と定義された群とが最も合致するような変数を選択する手法である。また、クラスター解析とは、全ての測定データの中で最も近い距離にある点同士をクラスタリング（群化）する手法である。また、決定木とは、変数に序列をつけて、序列が上位である変数の取りうるパターンから測定データの群を判別する手法である。 Here, the candidate formula created using principal component analysis is a linear formula containing each variable that maximizes the variance of all measured data. Candidate formulas created using discriminant analysis are high-order formulas (including exponentials and logarithms) that contain variables that minimize the ratio of the sum of variances within each group to the variance of all measured data. be. Also, the candidate formulas created using the support vector machine are high-order formulas (including kernel functions) containing each variable that maximizes the boundary between groups. A candidate formula created using multiple regression analysis is a high-order formula including each variable that minimizes the sum of distances from all measured data. A candidate formula created using Cox regression analysis is a linear model including a logarithmic hazard ratio, and is a linear formula including each variable and its coefficient that maximizes the likelihood of the model. A candidate formula created using logistic regression analysis is a linear model representing the logarithmic odds of probability, and is a linear formula containing each variable that maximizes the likelihood of that probability. In the k-means method, k neighbors of each measurement data are searched, and the group to which the input measurement data belongs is defined as the group to which the largest number of neighboring points belong. This is a method of selecting variables that best match the group defined as . Cluster analysis is a method of clustering (grouping) points that are closest to each other in all measurement data. A decision tree is a technique for assigning an order to variables and discriminating a group of measurement data from patterns that variables with higher order can take.
　式作成処理の説明に戻り、制御部は、工程１で作成した候補式を、所定の検証手法に基づいて検証（相互検証）する（工程２）。候補式の検証は、工程１で作成した各候補式に対して行う。なお、工程２において、ブートストラップ法やホールドアウト法、Ｎ－フォールド法、リーブワンアウト法などの複数の手法のうちの少なくとも１種類の手法に基づいて、候補式の判別率や感度、特異度、情報量基準（赤池情報量規準（ＡＩＣ）、ベイズ情報量基準（ＢＩＣ））、ＲＯＣ＿ＡＵＣ（受信者特性曲線の曲線下面積）、Ｃ－ｉｎｄｅｘ（Concordance　index）などの複数の指標のうちの少なくとも１種類の指標に関して検証してもよい。これにより、指標状態情報や評価条件を考慮した予測性または頑健性の高い候補式を作成することができる。 Returning to the description of the formula creation process, the control unit verifies (cross-verifies) the candidate formulas created in step 1 based on a predetermined verification method (step 2). Verification of the candidate formula is performed for each candidate formula created in step 1. In step 2, based on at least one of a plurality of methods such as the bootstrap method, holdout method, N-fold method, and leave-one-out method, the discrimination rate, sensitivity, and specificity of the candidate formula , Information Criterion (Akaike Information Criterion (AIC), Bayesian Information Criterion (BIC)), ROC_AUC (area under the receiver characteristic curve), C-index (Concordance index), etc. Verification may be performed with respect to one type of index. As a result, it is possible to create candidate formulas with high predictability or robustness that take into account index state information and evaluation conditions.
　ここで、判別率とは、本実施形態にかかる評価手法で、真の状態が陰性である評価対象（例えば採血から一定期間経過後に認知症を発症しなかった評価対象など）を正しく陰性と評価し、真の状態が陽性である評価対象（例えば採血から一定期間経過後に認知症を発症した評価対象など）を正しく陽性と評価している割合である。また、感度とは、本実施形態にかかる評価手法で、真の状態が陽性である評価対象を正しく陽性と評価している割合である。また、特異度とは、本実施形態にかかる評価手法で、真の状態が陰性である評価対象を正しく陰性と評価している割合である。また、赤池情報量規準（ＡＩＣ）とは、回帰分析などの場合に、観測データが統計モデルにどの程度一致するかを表す基準であり、「－２×（統計モデルの最大対数尤度）＋２×（統計モデルの自由パラメータ数）」で定義される値が最小となるモデルを最もよいと判断する。また、ベイズ情報量基準（ＢＩＣ）は、ベイズ統計学の考え方に基づいて導出されたモデル選択基準であり、「－２×（統計モデルの最大対数尤度）＋（統計モデルの自由パラメータ数）×ｌｎ（サンプルサイズ）」で定義される値が最小となるモデル（パラメータの少ないモデル）を最もよいと判断する。また、ＲＯＣ＿ＡＵＣは、２次元座標上に（ｘ，ｙ）＝（１－特異度，感度）をプロットして作成される曲線である受信者特性曲線（ＲＯＣ）の曲線下面積として定義され、ＲＯＣ＿ＡＵＣの値は完全な判別では１となり、この値が１に近いほど判別性が高いことを示す。また、Ｃ－ｉｎｄｅｘは、Ｈａｒｒｅｌｌらが提唱する予後予測の精度を表す指標であり、モデルから予測されるイベント発生確率と実際のイベント発生確率の大小関係がどの程度一致しているかを表すノンパラメトリックな指標である。また、予測性とは、候補式の検証を繰り返すことで得られた判別率や感度、特異度を平均したものである。また、頑健性とは、候補式の検証を繰り返すことで得られた判別率や感度、特異度の分散である。 Here, the discrimination rate is the evaluation method according to the present embodiment, and an evaluation subject whose true state is negative (e.g., an evaluation subject that did not develop dementia after a certain period of time from blood collection) is correctly evaluated as negative. However, it is the ratio of correct positive evaluation subjects whose true status is positive (for example, evaluation subjects who developed dementia after a certain period of time from blood sampling). In addition, the sensitivity is the ratio of correct positive evaluations of evaluation targets whose true state is positive in the evaluation method according to the present embodiment. Further, the specificity is the proportion of the evaluation targets whose true status is negative are correctly evaluated as negative in the evaluation method according to the present embodiment. In addition, the Akaike Information Criterion (AIC) is a criterion that indicates how well observed data matches a statistical model in the case of regression analysis, etc. x (the number of free parameters of the statistical model)” is judged to be the best model. In addition, the Bayesian Information Criterion (BIC) is a model selection criterion derived based on the concept of Bayesian statistics, "-2 × (maximum logarithmic likelihood of statistical model) + (number of free parameters of statistical model) x ln (sample size)” (model with few parameters) is determined to be the best. In addition, ROC_AUC is defined as the area under the receiver characteristic curve (ROC), which is a curve created by plotting (x, y) = (1-specificity, sensitivity) on two-dimensional coordinates. is 1 for perfect discrimination, and the closer this value is to 1, the higher the discriminability. In addition, the C-index is an index representing the accuracy of prognosis prediction proposed by Harrell et al. is a good indicator. The predictability is the average of discrimination rate, sensitivity, and specificity obtained by repeating verification of candidate formulas. Robustness is variance of discrimination rate, sensitivity, and specificity obtained by repeating verification of candidate formulas.
　式作成処理の説明に戻り、制御部は、所定の変数選択手法に基づいて候補式の変数を選択することで、候補式を作成する際に用いる指標状態情報に含まれる測定データの組み合わせを選択する（工程３）。なお、工程３において、変数の選択は、工程１で作成した各候補式に対して行ってもよい。これにより、候補式の変数を適切に選択することができる。そして、工程３で選択した測定データを含む指標状態情報を用いて再び工程１を実行する。また、工程３において、工程２での検証結果から、ステップワイズ法、ベストパス法、近傍探索法、および遺伝的アルゴリズムのうちの少なくとも１種類の手法に基づいて、候補式の変数を選択してもよい。なお、ベストパス法とは、候補式に含まれる変数を１個ずつ順次減らしていき、候補式が与える評価指標を最適化することで変数を選択する方法である。 Returning to the description of the formula creation process, the control unit selects a combination of measurement data included in the index state information used when creating the candidate formula by selecting variables of the candidate formula based on a predetermined variable selection method. (Step 3). In step 3, variables may be selected for each candidate formula created in step 1. This allows appropriate selection of the variables of the candidate formula. Then, using the index state information including the measurement data selected in step 3, step 1 is executed again. Further, in step 3, from the verification results in step 2, variables of the candidate formula are selected based on at least one of the stepwise method, best path method, neighborhood search method, and genetic algorithm. good too. The best path method is a method of selecting variables by sequentially reducing the variables included in the candidate formula one by one and optimizing the evaluation index given by the candidate formula.
　式作成処理の説明に戻り、制御部は、上述した工程１、工程２、および工程３を繰り返し実行し、これにより蓄積した検証結果に基づいて、複数の候補式の中から評価の際に用いる候補式を選出することで、評価の際に用いる式を作成する（工程４）。なお、候補式の選出には、例えば、同じ式作成手法で作成した候補式の中から最適なものを選出する場合と、すべての候補式の中から最適なものを選出する場合とがある。 Returning to the description of the formula creation process, the control unit repeatedly executes the above-described steps 1, 2, and 3, and based on the verification results accumulated by this, selects a candidate formula from among a plurality of candidate formulas to be used for evaluation. By selecting candidate formulas, a formula to be used for evaluation is created (step 4). Selection of candidate formulas includes, for example, selecting the optimum candidate formula from among candidate formulas prepared by the same formula preparation method, and selecting the optimum formula from all candidate formulas.
　以上、説明したように、式作成処理では、候補式の作成、候補式の検証、および候補式の変数の選択を、一連の流れで体系化（システム化）して実行することにより、認知症の将来の発症リスクの評価に最適な式を作成することができる。換言すると、式作成処理では、測定値を多変量の統計解析に用い、且つ、最適でロバストな変数の組を選択するために変数選択法とクロスバリデーションとを組み合わせることにより、評価性能の高い式を抽出する。 As described above, in the formula creation process, the creation of the candidate formula, the verification of the candidate formula, and the selection of the variables of the candidate formula are systematized and executed in a series of steps, thereby improving the dementia. can develop the optimal formula for assessing the risk of future onset of In other words, in the formula creation process, the measured values are used for multivariate statistical analysis, and by combining the variable selection method and cross-validation to select the optimal and robust set of variables, a formula with high evaluation performance to extract
［２－２．第２実施形態の構成］
　ここでは、第２実施形態にかかる評価システム（以下、「本システム」と記す場合がある。）の構成について、図３から図８を参照して説明する。なお、本システムはあくまでも一例であり、本発明はこれに限定されない。特に、ここでは、認知症の将来の発症リスクを評価する際に、式の値またはその変換後の値を用いるケースを一例として記載しているが、例えば、測定値またはその変換後の値（例えば偏差値など）を用いてもよい。 [2-2. Configuration of Second Embodiment]
Here, the configuration of the evaluation system (hereinafter sometimes referred to as "this system") according to the second embodiment will be described with reference to FIGS. 3 to 8. FIG. Note that this system is merely an example, and the present invention is not limited to this. In particular, here, when evaluating the risk of developing dementia in the future, the case of using the value of the formula or its converted value is described as an example, but for example, the measured value or its converted value ( For example, a deviation value, etc.) may be used.
　まず、本システムの全体構成について図３および図４を参照して説明する。図３は本システムの全体構成の一例を示す図である。また、図４は本システムの全体構成の他の一例を示す図である。本システムは、図３に示すように、評価対象である個体について認知症の将来の発症リスクを評価する評価装置１００と、個体の測定データを提供するクライアント装置２００（本発明の端末装置に相当）とを、ネットワーク３００を介して通信可能に接続して構成されている。 First, the overall configuration of this system will be described with reference to FIGS. 3 and 4. FIG. 3 is a diagram showing an example of the overall configuration of this system. FIG. 4 is a diagram showing another example of the overall configuration of this system. As shown in FIG. 3, this system comprises an evaluation device 100 that evaluates the risk of developing dementia in the future for an individual to be evaluated, and a client device 200 that provides measurement data of the individual (corresponding to the terminal device of the present invention). ) are communicably connected via the network 300 .
　なお、本システムにおいて、評価に用いられるデータの提供元となるクライアント装置２００と評価結果の提供先となるクライアント装置２００は別々のものであってもよい。本システムは、図４に示すように、評価装置１００やクライアント装置２００の他に、評価装置１００で式を作成する際に用いる指標状態情報や評価の際に用いる式などを格納したデータベース装置４００を、ネットワーク３００を介して通信可能に接続して構成されてもよい。 In this system, the client device 200 that provides the data used for evaluation and the client device 200 that provides the evaluation results may be separate devices. As shown in FIG. 4, in addition to the evaluation device 100 and the client device 200, the present system includes a database device 400 that stores index state information used to create formulas in the evaluation device 100, formulas used in evaluation, and the like. may be configured to be communicably connected via the network 300 .
　つぎに、本システムの評価装置１００の構成について図５から図１１を参照して説明する。図５は、本システムの評価装置１００の構成の一例を示すブロック図であり、該構成のうち本発明に関係する部分のみを概念的に示している。 Next, the configuration of the evaluation device 100 of this system will be described with reference to FIGS. 5 to 11. FIG. FIG. 5 is a block diagram showing an example of the configuration of the evaluation device 100 of this system, and conceptually shows only those portions of the configuration that are related to the present invention.
　評価装置１００は、当該評価装置を統括的に制御するＣＰＵ（Central　Processing　Unit）等の制御部１０２と、ルータ等の通信装置および専用線等の有線または無線の通信回線を介して当該評価装置をネットワーク３００に通信可能に接続する通信インターフェース部１０４と、各種のデータベースやテーブルやファイルなどを格納する記憶部１０６と、入力装置１１２や出力装置１１４に接続する入出力インターフェース部１０８と、で構成されており、これら各部は任意の通信路を介して通信可能に接続されている。ここで、評価装置１００は、各種の分析装置（例えば、測定対象を分析する分析装置等）と同一筐体で構成されてもよい。例えば、測定値を算出し、算出した測定値を出力（印刷やモニタ表示など）する構成（ハードウェアおよびソフトウェア）を備えた小型分析装置において、後述する評価部１０２ｄをさらに備え、当該評価部１０２ｄで得られた結果を前記構成を用いて出力すること、を特徴とするものでもよい。 The evaluation device 100 controls the evaluation device through a control unit 102 such as a CPU (Central Processing Unit) that controls the evaluation device, a communication device such as a router, and a wired or wireless communication line such as a dedicated line. It is composed of a communication interface unit 104 communicatively connected to the network 300, a storage unit 106 storing various databases, tables, files, etc., and an input/output interface unit 108 connected to the input device 112 and the output device 114. , and these units are communicably connected via an arbitrary communication path. Here, the evaluation device 100 may be configured in the same housing as various analysis devices (for example, an analysis device that analyzes a measurement target, etc.). For example, a small analyzer having a configuration (hardware and software) for calculating measured values and outputting (printing, monitor display, etc.) the calculated measured values further includes an evaluation unit 102d described later, and the evaluation unit 102d and outputting the result obtained by using the above configuration.
　通信インターフェース部１０４は、評価装置１００とネットワーク３００（またはルータ等の通信装置）との間における通信を媒介する。すなわち、通信インターフェース部１０４は、他の端末と通信回線を介してデータを通信する機能を有する。 The communication interface unit 104 mediates communication between the evaluation device 100 and the network 300 (or a communication device such as a router). That is, the communication interface unit 104 has a function of communicating data with another terminal via a communication line.
　入出力インターフェース部１０８は、入力装置１１２や出力装置１１４に接続する。ここで、出力装置１１４には、モニタ（家庭用テレビを含む）の他、スピーカやプリンタを用いることができる（なお、以下では、出力装置１１４をモニタ１１４と記載する場合がある。）。入力装置１１２には、キーボードやマウスやマイクの他、マウスと協働してポインティングデバイス機能を実現するモニタを用いることができる。 The input/output interface unit 108 connects to the input device 112 and the output device 114 . Here, the output device 114 may be a monitor (including a home television), a speaker, or a printer (below, the output device 114 may be referred to as the monitor 114). The input device 112 can be a keyboard, a mouse, a microphone, or a monitor that realizes a pointing device function in cooperation with a mouse.
　記憶部１０６は、ストレージ手段であり、例えば、ＲＡＭ（Random　Access　Memory）・ＲＯＭ（Read　Only　Memory）等のメモリ装置や、ハードディスクのような固定ディスク装置、フレキシブルディスク、光ディスク等を用いることができる。記憶部１０６には、ＯＳ（Operating　System）と協働してＣＰＵに命令を与え各種処理を行うためのコンピュータプログラムが記録されている。記憶部１０６は、図示の如く、測定データファイル１０６ａと、指標状態情報ファイル１０６ｂと、指定指標状態情報ファイル１０６ｃと、式関連情報データベース１０６ｄと、評価結果ファイル１０６ｅと、を格納する。 The storage unit 106 is storage means, and can use, for example, a memory device such as RAM (Random Access Memory) or ROM (Read Only Memory), a fixed disk device such as a hard disk, a flexible disk, an optical disk, or the like. The storage unit 106 stores a computer program that cooperates with the OS (Operating System) to issue commands to the CPU to perform various processes. As illustrated, the storage unit 106 stores a measurement data file 106a, an index state information file 106b, a designated index state information file 106c, a formula related information database 106d, and an evaluation result file 106e.
　測定データファイル１０６ａは、測定データを格納する。図６は、測定データファイル１０６ａに格納される情報の一例を示す図である。測定データファイル１０６ａに格納される情報は、図６に示すように、評価対象である個体（サンプル）を一意に識別するための個体番号と、測定データとを相互に関連付けて構成されている。ここで、図６では、測定データを数値、すなわち連続尺度として扱っているが、測定データは名義尺度や順序尺度でもよい。なお、測定データが名義尺度や順序尺度の場合は、各状態に対し与えた任意の数値を、評価や式の値の算出などの各種処理に用いてもよい。また、測定データに他の生体情報に関する値（上記参照）を組み合わせてもよい。 The measurement data file 106a stores measurement data. FIG. 6 is a diagram showing an example of information stored in the measurement data file 106a. As shown in FIG. 6, the information stored in the measurement data file 106a is configured by associating an individual number for uniquely identifying an individual (sample) to be evaluated with the measurement data. Here, in FIG. 6, the measured data are treated as numerical values, that is, as a continuous scale, but the measured data may be a nominal scale or an ordinal scale. If the measurement data is a nominal scale or an ordinal scale, arbitrary numerical values given to each state may be used for various processes such as evaluation and calculation of formula values. Also, the measured data may be combined with other biometric information values (see above).
　図５に戻り、指標状態情報ファイル１０６ｂは、式を作成する際に用いる指標状態情報を格納する。図７は、指標状態情報ファイル１０６ｂに格納される情報の一例を示す図である。指標状態情報ファイル１０６ｂに格納される情報は、図７に示すように、個体番号と、ＡＤの将来の発症リスクに関する指標データと、測定データと、を相互に関連付けて構成されている。ここで、図７では、指標データおよび測定データを数値、すなわち連続尺度として扱っているが、指標データおよび測定データは名義尺度や順序尺度でもよい。なお、指標データおよび測定データが名義尺度や順序尺度の場合は、各状態に対して与えた任意の数値を、評価や式の値の算出などの各種処理に用いてもよい。 Returning to FIG. 5, the index state information file 106b stores index state information used when formulating formulas. FIG. 7 is a diagram showing an example of information stored in the index state information file 106b. As shown in FIG. 7, the information stored in the index status information file 106b is configured by correlating individual numbers, index data regarding the risk of developing AD in the future, and measurement data. Here, in FIG. 7, index data and measurement data are treated as numerical values, that is, continuous scales, but index data and measurement data may be nominal scales or ordinal scales. When the index data and measurement data are nominal scales or ordinal scales, arbitrary numerical values given to each state may be used for various processes such as evaluation and calculation of formula values.
　図５に戻り、指定指標状態情報ファイル１０６ｃは、後述する指定部１０２ｂで指定した指標状態情報を格納する。図８は、指定指標状態情報ファイル１０６ｃに格納される情報の一例を示す図である。指定指標状態情報ファイル１０６ｃに格納される情報は、図８に示すように、個体番号と、指定した指標データと、指定した測定データと、を相互に関連付けて構成されている。 Returning to FIG. 5, the designated index state information file 106c stores the index state information designated by the later-described designation section 102b. FIG. 8 is a diagram showing an example of information stored in the specified index state information file 106c. As shown in FIG. 8, the information stored in the designated index state information file 106c is configured by associating individual numbers, designated index data, and designated measurement data.
　図５に戻り、式関連情報データベース１０６ｄは、後述する式作成部１０２ｃで作成した式を格納する式ファイル１０６ｄ１で構成される。式ファイル１０６ｄ１は、評価の際に用いる式を格納する。図９は、式ファイル１０６ｄ１に格納される情報の一例を示す図である。式ファイル１０６ｄ１に格納される情報は、図９に示すように、ランクと、式（図９では、Ｆｐ(Ｈｉｓ，・・・）やＦｐ(Ｈｉｓ，３ｈ－Ｋｙｎ，Ｋｙｎ）、Ｆｋ(Ｈｉｓ，３ｈ－Ｋｙｎ，Ｋｙｎ，・・・）など）と、各式作成手法に対応する閾値と、各式の検証結果（例えば各式の値）と、を相互に関連付けて構成されている。 Returning to FIG. 5, the formula-related information database 106d is composed of formula files 106d1 that store formulas created by the formula creating unit 102c, which will be described later. The formula file 106d1 stores formulas used for evaluation. FIG. 9 is a diagram showing an example of information stored in the formula file 106d1. Information stored in the formula file 106d1 includes ranks, formulas (in FIG. 9, Fp(His, . . . ), Fp(His, 3h-Kyn, Kyn), Fk(His, 3h-Kyn, Kyn, .
　図５に戻り、評価結果ファイル１０６ｅは、後述する評価部１０２ｄで得られた評価結果を格納する。図１０は、評価結果ファイル１０６ｅに格納される情報の一例を示す図である。評価結果ファイル１０６ｅに格納される情報は、評価対象である個体（サンプル）を一意に識別するための個体番号と、予め取得した個体の測定データと、認知症の将来の発症リスクに関する評価結果（例えば、後述する算出部１０２ｄ１で算出した式の値、後述する変換部１０２ｄ２で式の値を変換した後の値、後述する生成部１０２ｄ３で生成した位置情報、または後述する分類部１０２ｄ４で得られた分類結果など）と、を相互に関連付けて構成されている。 Returning to FIG. 5, the evaluation result file 106e stores evaluation results obtained by the evaluation unit 102d, which will be described later. FIG. 10 is a diagram showing an example of information stored in the evaluation result file 106e. The information stored in the evaluation result file 106e includes an individual number for uniquely identifying the individual (sample) to be evaluated, measurement data of the individual obtained in advance, and an evaluation result regarding the risk of developing dementia in the future ( For example, a value of a formula calculated by a calculation unit 102d1, which will be described later, a value after converting the value of a formula by a conversion unit 102d2, which will be described later, position information generated by a generation unit 102d3, which will be described later, or obtained by a classification unit 102d4, which will be described later. classification results, etc.) and are associated with each other.
　図５に戻り、制御部１０２は、ＯＳ等の制御プログラム・各種の処理手順等を規定したプログラム・所要データなどを格納するための内部メモリを有し、これらのプログラムに基づいて種々の情報処理を実行する。制御部１０２は、図示の如く、大別して、取得部１０２ａと指定部１０２ｂと式作成部１０２ｃと評価部１０２ｄと結果出力部１０２ｅと送信部１０２ｆとを備えている。制御部１０２は、データベース装置４００から送信された指標状態情報やクライアント装置２００から送信された測定データに対して、欠損値のあるデータの除去・外れ値の多いデータの除去・欠損値のあるデータの多い変数の除去などのデータ処理も行う。 Returning to FIG. 5, the control unit 102 has an internal memory for storing a control program such as an OS, a program defining various processing procedures, required data, and the like, and performs various information processing based on these programs. to run. As illustrated, the control unit 102 is roughly divided into an acquisition unit 102a, a designation unit 102b, an expression creation unit 102c, an evaluation unit 102d, a result output unit 102e, and a transmission unit 102f. The control unit 102 removes data with missing values, removes data with many outliers, and removes data with missing values from the index state information sent from the database device 400 and the measurement data sent from the client device 200. We also perform data processing such as removing variables with a large number of
　取得部１０２ａは、情報（具体的には、測定データや指標状態情報、式など）を取得する。例えば、取得部１０２ａは、クライアント装置２００やデータベース装置４００から送信された情報（具体的には、測定データや指標状態情報、式など）を、ネットワーク３００などを介して受信することで、情報の取得を行ってもよい。なお、取得部１０２ａは、評価結果の送信先のクライアント装置２００とは異なるクライアント装置２００から送信された評価に用いられるデータを受信してもよい。また、例えば、記録媒体に記録されている情報の読み出しを行うための機構（ハードウェアおよびソフトウェアを含む）を評価装置１００が備える場合、取得部１０２ａは、記録媒体に記録されている情報（具体的には、測定データや指標状態情報、式など）を当該機構を介して読み出すことで、情報の取得を行ってもよい。指定部１０２ｂは、式を作成するにあたり対象とする指標データおよび測定データを指定する。 The acquisition unit 102a acquires information (specifically, measurement data, index state information, formulas, etc.). For example, the acquisition unit 102a receives information (specifically, measurement data, index state information, formulas, etc.) transmitted from the client device 200 or the database device 400 via the network 300 or the like. Acquisition may be performed. Note that the acquisition unit 102a may receive data used for evaluation transmitted from a client device 200 different from the client device 200 to which the evaluation result is transmitted. Further, for example, when the evaluation device 100 includes a mechanism (including hardware and software) for reading information recorded on the recording medium, the acquisition unit 102a reads the information recorded on the recording medium (specifically, Specifically, information may be obtained by reading measurement data, index state information, formulas, etc.) via the mechanism. The designating unit 102b designates target index data and measurement data when creating a formula.
　式作成部１０２ｃは、取得部１０２ａで取得した指標状態情報や指定部１０２ｂで指定した指標状態情報に基づいて式を作成する。なお、式が予め記憶部１０６の所定の記憶領域に格納されている場合には、式作成部１０２ｃは、記憶部１０６から所望の式を選択することで、式を作成してもよい。また、式作成部１０２ｃは、式を予め格納した他のコンピュータ装置（例えばデータベース装置４００）から所望の式を選択しダウンロードすることで、式を作成してもよい。 The formula creation unit 102c creates a formula based on the index state information acquired by the acquisition unit 102a and the index state information specified by the specification unit 102b. Note that, when formulas are stored in advance in a predetermined storage area of the storage unit 106, the formula creation unit 102c may create a formula by selecting a desired formula from the storage unit 106. FIG. Alternatively, the formula creation unit 102c may create a formula by selecting and downloading a desired formula from another computer device (for example, the database device 400) in which formulas are stored in advance.
　評価部１０２ｄは、事前に得られた式（例えば式作成部１０２ｃで作成した式または取得部１０２ａで取得した式など）および取得部１０２ａで取得した個体の測定データに含まれる測定値を用いて式の値を算出することで、個体について認知症の将来の発症リスクを評価する。なお、評価部１０２ｄは、測定値またはその変換後の値（例えば偏差値）を用いて、個体について認知症の将来の発症リスクを評価してもよい。 The evaluation unit 102d uses a formula obtained in advance (for example, a formula created by the formula creation unit 102c or a formula acquired by the acquisition unit 102a) and measurement values included in the individual measurement data acquired by the acquisition unit 102a. Calculating the value of the formula assesses the individual's risk of future development of dementia. Note that the evaluation unit 102d may use the measured value or its converted value (for example, deviation value) to evaluate the future risk of developing dementia for the individual.
　ここで、評価部１０２ｄの構成について図１１を参照して説明する。図１１は、評価部１０２ｄの構成を示すブロック図であり、当該構成のうち本発明に関係する部分のみを概念的に示している。評価部１０２ｄは、算出部１０２ｄ１と、変換部１０２ｄ２と、生成部１０２ｄ３と、分類部１０２ｄ４と、をさらに備えている。 Here, the configuration of the evaluation unit 102d will be described with reference to FIG. FIG. 11 is a block diagram showing the structure of the evaluation unit 102d, and conceptually shows only the part of the structure related to the present invention. The evaluation unit 102d further includes a calculation unit 102d1, a conversion unit 102d2, a generation unit 102d3, and a classification unit 102d4.
　算出部１０２ｄ１は、測定値が代入される変数を含む式および測定データに含まれる測定値を用いて、式の値を算出する。なお、評価部１０２ｄは、算出部１０２ｄ１で算出した式の値を評価結果として評価結果ファイル１０６ｅの所定の記憶領域に格納してもよい。 The calculation unit 102d1 calculates the value of the formula using the formula including variables into which the measured values are substituted and the measured values included in the measured data. Note that the evaluation unit 102d may store the value of the formula calculated by the calculation unit 102d1 as the evaluation result in a predetermined storage area of the evaluation result file 106e.
　変換部１０２ｄ２は、算出部１０２ｄ１で算出した式の値を例えば上述した変換手法などで変換する。なお、評価部１０２ｄは、変換部１０２ｄ２で変換した後の値を評価結果として評価結果ファイル１０６ｅの所定の記憶領域に格納してもよい。また、変換部１０２ｄ２は、測定データに含まれる測定値を、例えば上述した変換手法などで変換してもよい。 The conversion unit 102d2 converts the value of the formula calculated by the calculation unit 102d1, for example, using the conversion method described above. Note that the evaluation unit 102d may store the value converted by the conversion unit 102d2 as the evaluation result in a predetermined storage area of the evaluation result file 106e. Further, the conversion unit 102d2 may convert the measured value included in the measurement data, for example, using the conversion method described above.
　生成部１０２ｄ３は、モニタ等の表示装置または紙等の物理媒体に視認可能に示される所定の物差し上における所定の目印の位置に関する位置情報を、算出部１０２ｄ１で算出した式の値または変換部１０２ｄ２で変換した後の値（測定値またはその変換後の値でもよい）を用いて生成する。なお、評価部１０２ｄは、生成部１０２ｄ３で生成した位置情報を評価結果として評価結果ファイル１０６ｅの所定の記憶領域に格納してもよい。 Generating unit 102d3 converts position information about the position of a predetermined mark on a predetermined ruler visibly displayed on a display device such as a monitor or on a physical medium such as paper into the value of the formula calculated by calculating unit 102d1 or the converting unit 102d2. It is generated using the value after conversion by (it may be the measured value or the value after conversion). The evaluation unit 102d may store the position information generated by the generation unit 102d3 as the evaluation result in a predetermined storage area of the evaluation result file 106e.
　分類部１０２ｄ４は、算出部１０２ｄ１で算出した式の値または変換部１０２ｄ２で変換した後の値（測定値またはその変換後の値でもよい）を用いて、個体を、認知症の将来の発症リスクを少なくとも考慮して定義された複数の区分のうちのどれか１つの区分に分類する。 The classification unit 102d4 uses the value of the formula calculated by the calculation unit 102d1 or the value after conversion by the conversion unit 102d2 (measured value or the converted value may be used) to classify the individual at the future onset risk of dementia. into any one of a plurality of categories defined taking into account at least the .
　結果出力部１０２ｅは、制御部１０２の各処理部での処理結果（評価部１０２ｄで得られた評価結果を含む）等を出力装置１１４に出力する。 The result output unit 102e outputs to the output device 114 the processing results of each processing unit of the control unit 102 (including the evaluation results obtained by the evaluation unit 102d).
　送信部１０２ｆは、個体の測定データの送信元のクライアント装置２００に対して評価結果を送信したり、データベース装置４００に対して、評価装置１００で作成した式や評価結果を送信したりする。なお、送信部１０２ｆは、評価に用いられるデータの送信元のクライアント装置２００とは異なるクライアント装置２００に対して評価結果を送信してもよい。 The transmission unit 102f transmits evaluation results to the client device 200 that is the transmission source of the individual measurement data, and transmits formulas created by the evaluation device 100 and evaluation results to the database device 400. Note that the transmission unit 102f may transmit the evaluation result to a client device 200 different from the client device 200 that is the transmission source of the data used for evaluation.
　つぎに、本システムのクライアント装置２００の構成について図１２を参照して説明する。図１２は、本システムのクライアント装置２００の構成の一例を示すブロック図であり、該構成のうち本発明に関係する部分のみを概念的に示している。 Next, the configuration of the client device 200 of this system will be described with reference to FIG. FIG. 12 is a block diagram showing an example of the configuration of the client device 200 of this system, and conceptually shows only those portions of the configuration that are related to the present invention.
　クライアント装置２００は、制御部２１０とＲＯＭ２２０とＨＤ（Hard　Disk）２３０とＲＡＭ２４０と入力装置２５０と出力装置２６０と入出力ＩＦ２７０と通信ＩＦ２８０とで構成されており、これら各部は任意の通信路を介して通信可能に接続されている。クライアント装置２００は、プリンタ・モニタ・イメージスキャナ等の周辺装置を必要に応じて接続した情報処理装置（例えば、パーソナルコンピュータ・ワークステーション・家庭用ゲーム装置・インターネットＴＶ・ＰＨＳ（Personal　Handyphone　System）端末・携帯端末・移動体通信端末・ＰＤＡ（Personal　Digital　Assistant）等の既知の情報処理端末など）を基にしたものであってもよい。 The client device 200 is composed of a control unit 210, a ROM 220, a HD (Hard Disk) 230, a RAM 240, an input device 250, an output device 260, an input/output IF 270, and a communication IF 280. are connected so that they can communicate with each other. The client device 200 is an information processing device (for example, a personal computer, a workstation, a home game device, an Internet TV, a PHS (Personal Handyphone System) terminal, etc.) to which peripheral devices such as a printer, monitor, and image scanner are connected as necessary. Known information processing terminals such as portable terminals, mobile communication terminals, PDA (Personal Digital Assistant), etc.) may also be used.
　入力装置２５０はキーボードやマウスやマイク等である。なお、後述するモニタ２６１もマウスと協働してポインティングデバイス機能を実現する。出力装置２６０は、通信ＩＦ２８０を介して受信した情報を出力する出力手段であり、モニタ（家庭用テレビを含む）２６１およびプリンタ２６２を含む。この他、出力装置２６０にスピーカ等を設けてもよい。入出力ＩＦ２７０は入力装置２５０や出力装置２６０に接続する。 The input device 250 is a keyboard, mouse, microphone, or the like. A monitor 261, which will be described later, also cooperates with the mouse to realize the pointing device function. Output device 260 is output means for outputting information received via communication IF 280 , and includes monitor (including home television) 261 and printer 262 . In addition, the output device 260 may be provided with a speaker or the like. The input/output IF 270 connects to the input device 250 and the output device 260 .
　通信ＩＦ２８０は、クライアント装置２００とネットワーク３００（またはルータ等の通信装置）とを通信可能に接続する。換言すると、クライアント装置２００は、通信装置（例えばモデムやＴＡ（Terminal　Adapter）、ルータなど）および電話回線を介してまたは専用線を介して、ネットワーク３００に接続される。これにより、クライアント装置２００は、所定の通信規約に従って評価装置１００にアクセスすることができる。 The communication IF 280 communicably connects the client device 200 and the network 300 (or a communication device such as a router). In other words, the client device 200 is connected to the network 300 via a communication device (eg, modem, TA (Terminal Adapter), router, etc.) and a telephone line or a dedicated line. Thereby, the client device 200 can access the evaluation device 100 according to a predetermined communication protocol.
　制御部２１０は、受信部２１１および送信部２１２を備えている。受信部２１１は、通信ＩＦ２８０を介して、評価装置１００から送信された評価結果などの各種情報を受信する。送信部２１２は、通信ＩＦ２８０を介して、個体の測定データなどの各種情報を評価装置１００へ送信する。 The control unit 210 includes a receiving unit 211 and a transmitting unit 212. The receiving unit 211 receives various information such as evaluation results transmitted from the evaluation device 100 via the communication IF 280 . The transmission unit 212 transmits various types of information such as individual measurement data to the evaluation device 100 via the communication IF 280 .
　制御部２１０は、当該制御部で行う処理の全部または任意の一部を、ＣＰＵおよび当該ＣＰＵにて解釈して実行するプログラムで実現してもよい。ＲＯＭ２２０またはＨＤ２３０には、ＯＳと協働してＣＰＵに命令を与え、各種処理を行うためのコンピュータプログラムが記録されている。当該コンピュータプログラムは、ＲＡＭ２４０にロードされることで実行され、ＣＰＵと協働して制御部２１０を構成する。また、当該コンピュータプログラムは、クライアント装置２００と任意のネットワークを介して接続されるアプリケーションプログラムサーバに記録されてもよく、クライアント装置２００は、必要に応じてその全部または一部をダウンロードしてもよい。また、制御部２１０で行う処理の全部または任意の一部を、ワイヤードロジック等によるハードウェアで実現してもよい。 The control unit 210 may realize all or any part of the processing performed by the control unit by a CPU and a program interpreted and executed by the CPU. The ROM 220 or HD 230 stores a computer program for giving instructions to the CPU in cooperation with the OS and performing various processes. The computer program is executed by being loaded into the RAM 240 and configures the control unit 210 in cooperation with the CPU. Also, the computer program may be recorded in an application program server connected to the client device 200 via any network, and the client device 200 may download all or part of it as necessary. . Also, all or any part of the processing performed by the control unit 210 may be realized by hardware such as wired logic.
　ここで、制御部２１０は、評価装置１００に備えられている評価部１０２ｄが有する機能と同様の機能を有する評価部２１０ａ（算出部２１０ａ１、変換部２１０ａ２、生成部２１０ａ３、および分類部２１０ａ４を含む）を備えていてもよい。そして、制御部２１０に評価部２１０ａが備えられている場合には、評価部２１０ａは、評価装置１００から送信された評価結果に含まれている情報に応じて、変換部２１０ａ２で式の値（測定値でもよい）を変換したり、生成部２１０ａ３で式の値または変換後の値（測定値またはその変換後の値でもよい）に対応する位置情報を生成したり、分類部２１０ａ４で式の値または変換後の値（測定値またはその変換後の値でもよい）を用いて個体を複数の区分のうちのどれか１つの区分に分類したりしてもよい。 Here, the control unit 210 includes an evaluation unit 210a (including a calculation unit 210a1, a conversion unit 210a2, a generation unit 210a3, and a classification unit 210a4) having the same function as the evaluation unit 102d provided in the evaluation apparatus 100. ). When the control unit 210 is provided with the evaluation unit 210a, the evaluation unit 210a causes the conversion unit 210a2 to convert the expression value ( The generation unit 210a3 generates position information corresponding to the value of the formula or the value after conversion (which may be the measured value or the value after conversion), and the classification unit 210a4 generates the position information corresponding to the value of the formula. A value or a transformed value (measured value or transformed value may be used) may be used to classify an individual into one of a plurality of categories.
　つぎに、本システムのネットワーク３００について図３および図４を参照して説明する。ネットワーク３００は、評価装置１００とクライアント装置２００とデータベース装置４００とを相互に通信可能に接続する機能を有し、例えばインターネットやイントラネット、ＬＡＮ（Local　Area　Network)(有線／無線の双方を含む）等である。なお、ネットワーク３００は、ＶＡＮ(Value-Added　Network）や、パソコン通信網や、公衆電話網（アナログ／デジタルの双方を含む）や、専用回線網（アナログ／デジタルの双方を含む）や、ＣＡＴＶ（Community　Antenna　TeleVision）網や、携帯回線交換網または携帯パケット交換網（ＩＭＴ（International　Mobile　Telecommunication）２０００方式、ＧＳＭ（登録商標)(Global　System　for　Mobile　Communications）方式、またはＰＤＣ（Personal　Digital　Cellular）／ＰＤＣ－Ｐ方式等を含む）や、無線呼出網や、局所無線網（Bluetooth（登録商標）等を含む）や、ＰＨＳ網や、衛星通信網（ＣＳ（Communication　Satellite）、ＢＳ（Broadcasting　Satellite）、またはＩＳＤＢ（Integrated　Services　Digital　Broadcasting）等を含む）等でもよい。 Next, the network 300 of this system will be explained with reference to FIGS. 3 and 4. FIG. The network 300 has a function of connecting the evaluation device 100, the client device 200, and the database device 400 so that they can communicate with each other. is. Note that the network 300 includes a VAN (Value-Added Network), a personal computer communication network, a public telephone network (including both analog and digital), a leased line network (including both analog and digital), CATV ( Community Antenna TeleVision) network, mobile circuit switched network or mobile packet switched network (IMT (International Mobile Telecommunication) 2000 system, GSM (registered trademark) (Global System for Mobile Communications) system, or PDC (Personal Digital Cellular) / PDC- P system, etc.), radio call network, local wireless network (including Bluetooth (registered trademark), etc.), PHS network, satellite communication network (CS (Communication Satellite), BS (Broadcasting Satellite), or ISDB (including Integrated Services Digital Broadcasting), etc.).
　つぎに、本システムのデータベース装置４００の構成について図１３を参照して説明する。図１３は、本システムのデータベース装置４００の構成の一例を示すブロック図であり、該構成のうち本発明に関係する部分のみを概念的に示している。 Next, the configuration of the database device 400 of this system will be described with reference to FIG. FIG. 13 is a block diagram showing an example of the configuration of the database device 400 of this system, and conceptually shows only those portions of the configuration related to the present invention.
　データベース装置４００は、評価装置１００または当該データベース装置で式を作成する際に用いる指標状態情報や評価装置１００で作成した式、評価装置１００での評価結果などを格納する機能を有する。図１３に示すように、データベース装置４００は、当該データベース装置を統括的に制御するＣＰＵ等の制御部４０２と、通信装置（ルータ等）および有線または無線の通信回路（専用線等）を介して当該データベース装置をネットワーク３００に通信可能に接続する通信インターフェース部４０４と、各種のデータベースやテーブルやファイル（例えばＷｅｂページ用ファイル）などを格納する記憶部４０６と、入力装置４１２や出力装置４１４に接続する入出力インターフェース部４０８と、で構成されており、これら各部は任意の通信路を介して通信可能に接続されている。 The database device 400 has a function of storing index state information used when formulas are created by the evaluation device 100 or the database device, formulas created by the evaluation device 100, evaluation results by the evaluation device 100, and the like. As shown in FIG. 13, the database device 400 includes a control unit 402 such as a CPU that controls the database device, a communication device (router, etc.), and a wired or wireless communication circuit (dedicated line, etc.). It is connected to a communication interface unit 404 that communicably connects the database device to the network 300, a storage unit 406 that stores various databases, tables, files (for example, files for web pages), an input device 412, and an output device 414. and an input/output interface unit 408, and these units are communicably connected via an arbitrary communication path.
　記憶部４０６は、ストレージ手段であり、例えば、ＲＡＭ・ＲＯＭ等のメモリ装置や、ハードディスクのような固定ディスク装置や、フレキシブルディスクや、光ディスク等を用いることができる。記憶部４０６は、各種処理に用いる各種プログラム等を格納する。通信インターフェース部４０４は、データベース装置４００とネットワーク３００（またはルータ等の通信装置）との間における通信を媒介する。すなわち、通信インターフェース部４０４は、他の端末と通信回線を介してデータを通信する機能を有する。入出力インターフェース部４０８は、入力装置４１２や出力装置４１４に接続する。ここで、出力装置４１４には、モニタ（家庭用テレビを含む）の他、スピーカやプリンタを用いることができる。また、入力装置４１２には、キーボードやマウスやマイクの他、マウスと協働してポインティングデバイス機能を実現するモニタを用いることができる。 The storage unit 406 is storage means, and can use, for example, a memory device such as RAM/ROM, a fixed disk device such as a hard disk, a flexible disk, an optical disk, or the like. The storage unit 406 stores various programs and the like used for various processes. The communication interface unit 404 mediates communication between the database device 400 and the network 300 (or a communication device such as a router). That is, the communication interface unit 404 has a function of communicating data with another terminal via a communication line. The input/output interface unit 408 connects to the input device 412 and the output device 414 . Here, the output device 414 can be a monitor (including a home television), a speaker, or a printer. Also, the input device 412 can be a keyboard, a mouse, a microphone, or a monitor that realizes a pointing device function in cooperation with a mouse.
　制御部４０２は、ＯＳ等の制御プログラム・各種の処理手順等を規定したプログラム・所要データなどを格納するための内部メモリを有し、これらのプログラムに基づいて種々の情報処理を実行する。制御部４０２は、図示の如く、大別して、送信部４０２ａと受信部４０２ｂを備えている。送信部４０２ａは、指標状態情報や式などの各種情報を、評価装置１００へ送信する。受信部４０２ｂは、評価装置１００から送信された、式や評価結果などの各種情報を受信する。 The control unit 402 has an internal memory for storing control programs such as an OS, programs defining various processing procedures, required data, and the like, and executes various information processing based on these programs. As illustrated, the control unit 402 is roughly divided into a transmission unit 402a and a reception unit 402b. The transmitting unit 402a transmits various types of information such as index state information and formulas to the evaluation apparatus 100. FIG. The receiving unit 402b receives various information such as formulas and evaluation results transmitted from the evaluation apparatus 100 .
　なお、本説明では、評価装置１００が、測定データの受信から、式の値の算出、個体の区分への分類、そして評価結果の送信までを実行し、クライアント装置２００が評価結果の受信を実行するケースを例として挙げたが、クライアント装置２００に評価部２１０ａが備えられている場合は、評価装置１００は式の値の算出を実行すれば十分であり、例えば式の値の変換、位置情報の生成、および個体の区分への分類などは、評価装置１００とクライアント装置２００とで適宜分担して実行してもよい。
　例えば、クライアント装置２００が評価装置１００から式の値を受信した場合には、評価部２１０ａは、変換部２１０ａ２で式の値を変換したり、生成部２１０ａ３で式の値またはその変換後の値に対応する位置情報を生成したり、分類部２１０ａ４で式の値またはその変換後の値を用いて個体を複数の区分のうちのどれか１つの区分に分類したりしてもよい。
　また、クライアント装置２００が評価装置１００から変換後の値を受信した場合には、評価部２１０ａは、生成部２１０ａ３で変換後の値に対応する位置情報を生成したり、分類部２１０ａ４で変換後の値を用いて個体を複数の区分のうちのどれか１つの区分に分類したりしてもよい。
　また、クライアント装置２００は、評価装置１００から式の値またはその変換後の値と位置情報とを受信した場合には、評価部２１０ａは、分類部２１０ａ４で式の値またはその変換後の値を用いて個体を複数の区分のうちのどれか１つの区分に分類してもよい。 In this description, the evaluation device 100 receives the measurement data, calculates the value of the formula, classifies the individuals into categories, and transmits the evaluation results, and the client device 200 receives the evaluation results. However, if the client device 200 is provided with the evaluation unit 210a, it is sufficient for the evaluation device 100 to calculate the value of the expression. , classification of individuals into categories, and the like may be appropriately shared between the evaluation device 100 and the client device 200 .
For example, when the client device 200 receives the value of the expression from the evaluation device 100, the evaluation unit 210a converts the value of the expression with the conversion unit 210a2, and the value of the expression or the converted value with the generation unit 210a3. Alternatively, the classification unit 210a4 may classify the individual into any one of a plurality of classes using the value of the formula or the converted value thereof.
When the client device 200 receives a converted value from the evaluation device 100, the evaluation unit 210a causes the generation unit 210a3 to generate location information corresponding to the converted value, or the classification unit 210a4 to generate location information corresponding to the converted value. Individuals may be classified into any one of a plurality of categories using the value of .
Further, when the client device 200 receives the value of the formula or its converted value and the position information from the evaluation device 100, the evaluation unit 210a classifies the value of the formula or its converted value in the classification unit 210a4. may be used to classify an individual into any one of a plurality of categories.
［２－３．他の実施形態］
　本発明にかかる評価装置、算出装置、評価方法、算出方法、評価プログラム、算出プログラム、評価システム、および端末装置は、上述した第２実施形態以外にも、請求の範囲に記載した技術的思想の範囲内において種々の異なる実施形態にて実施されてよいものである。 [2-3. Other embodiments]
The evaluation device, the calculation device, the evaluation method, the calculation method, the evaluation program, the calculation program, the evaluation system, and the terminal device according to the present invention are not limited to the above-described second embodiment. Various different embodiments may be implemented within the scope.
　また、第２実施形態において説明した各処理のうち、自動的に行われるものとして説明した処理の全部または一部を手動的に行うこともでき、あるいは、手動的に行われるものとして説明した処理の全部または一部を公知の方法で自動的に行うこともできる。 Further, among the processes described in the second embodiment, all or part of the processes described as being automatically performed can be performed manually, or the processes described as being performed manually can be performed manually. can also be performed automatically by known methods.
　また、本明細書中や図面中で示した、処理手順、制御手順、具体的名称、各処理の登録データや検索条件等のパラメータを含む情報、画面例、およびデータベース構成については、特記する場合を除いて任意に変更することができる。 In addition, the processing procedures, control procedures, specific names, information including parameters such as registration data and search conditions for each process, screen examples, and database configurations shown in this specification and drawings may not be specified unless otherwise specified. can be changed arbitrarily except for
　また、評価システムを構成する各装置に関して、図示の各構成要素は機能概念的なものであり、必ずしも物理的に図示の如く構成されていることを要しない。 In addition, regarding each device that constitutes the evaluation system, each component shown in the figure is functionally conceptual, and does not necessarily need to be physically configured as shown in the figure.
　例えば、評価装置１００が備える処理機能、特に制御部１０２にて行われる各処理機能については、その全部または任意の一部を、ＣＰＵおよび当該ＣＰＵにて解釈実行されるプログラムにて実現してもよく、また、ワイヤードロジックによるハードウェアとして実現してもよい。尚、プログラムは、情報処理装置に本発明にかかる評価方法を実行させるためのプログラム化された命令を含む一時的でないコンピュータ読み取り可能な記録媒体に記録されており、必要に応じて評価装置１００に機械的に読み取られる。すなわち、ＲＯＭまたはＨＤＤなどの記憶部１０６には、ＯＳと協働してＣＰＵに命令を与え、各種処理を行うためのコンピュータプログラムが記録されている。このコンピュータプログラムは、ＲＡＭにロードされることによって実行され、ＣＰＵと協働して制御部を構成する。 For example, the processing functions provided by the evaluation device 100, particularly the processing functions performed by the control unit 102, may be implemented in whole or in part by a CPU and a program interpreted and executed by the CPU. Alternatively, it may be implemented as hardware by wired logic. The program is recorded on a non-temporary computer-readable recording medium containing programmed instructions for causing the information processing apparatus to execute the evaluation method according to the present invention. read mechanically. That is, the storage unit 106 such as ROM or HDD stores computer programs for giving commands to the CPU in cooperation with the OS to perform various processes. This computer program is executed by being loaded into the RAM and constitutes a control section in cooperation with the CPU.
　また、このコンピュータプログラムは、評価装置１００に対して任意のネットワークを介して接続されたアプリケーションプログラムサーバに記憶されていてもよく、必要に応じてその全部または一部をダウンロードすることも可能である。 Also, this computer program may be stored in an application program server connected to the evaluation apparatus 100 via any network, and it is possible to download all or part of it as necessary. .
　また、本発明にかかる評価プログラムを、一時的でないコンピュータ読み取り可能な記録媒体に格納してもよく、また、プログラム製品として構成することもできる。ここで、この「記録媒体」とは、メモリーカード、ＵＳＢメモリ、ＳＤカード、フレキシブルディスク、光磁気ディスク、ＲＯＭ、ＥＰＲＯＭ、ＥＥＰＲＯＭ（登録商標）、ＣＤ－ＲＯＭ、ＭＯ、ＤＶＤ、およびＢｌｕ－ｒａｙ（登録商標）　Ｄｉｓｃ等の任意の「可搬用の物理媒体」を含むものとする。 Also, the evaluation program according to the present invention may be stored in a non-temporary computer-readable recording medium, or may be configured as a program product. Here, this "recording medium" includes memory cards, USB memories, SD cards, flexible disks, magneto-optical disks, ROMs, EPROMs, EEPROMs (registered trademark), CD-ROMs, MOs, DVDs, and Blu-ray ( (registered trademark) include any "portable physical media" such as Discs.
　また、「プログラム」とは、任意の言語または記述方法にて記述されたデータ処理方法であり、ソースコードまたはバイナリコード等の形式を問わない。なお、「プログラム」は必ずしも単一的に構成されるものに限られず、複数のモジュールやライブラリとして分散構成されるものや、ＯＳに代表される別個のプログラムと協働してその機能を達成するものも含む。なお、実施形態に示した各装置において記録媒体を読み取るための具体的な構成および読み取り手順ならびに読み取り後のインストール手順等については、周知の構成や手順を用いることができる。 In addition, a "program" is a data processing method written in any language or writing method, regardless of the format such as source code or binary code. In addition, the "program" is not necessarily limited to a single configuration, but is distributed as multiple modules or libraries, or cooperates with a separate program represented by the OS to achieve its function. Including things. It should be noted that well-known configurations and procedures can be used for the specific configuration and reading procedure for reading the recording medium in each device shown in the embodiments, the installation procedure after reading, and the like.
　記憶部に格納される各種のデータベース等は、ＲＡＭ・ＲＯＭ等のメモリ装置、ハードディスク等の固定ディスク装置、フレキシブルディスク、および光ディスク等のストレージ手段であり、各種処理やウェブサイト提供に用いる、各種のプログラム、テーブル、データベース、およびウェブページ用ファイル等を格納する。 The various databases stored in the storage unit are storage means such as memory devices such as RAM and ROM, fixed disk devices such as hard disks, flexible disks, and optical disks. Stores programs, tables, databases, files for web pages, and so on.
　また、評価装置１００は、既知のパーソナルコンピュータもしくはワークステーション等の情報処理装置または任意の周辺装置が接続された情報処理装置として構成してもよい。また、評価装置１００は、当該情報処理装置に本発明の評価方法を実現させるソフトウェア（プログラムまたはデータ等を含む）を実装することにより実現してもよい。 Also, the evaluation device 100 may be configured as an information processing device such as a known personal computer or workstation, or an information processing device to which any peripheral device is connected. Moreover, the evaluation device 100 may be realized by installing software (including programs, data, etc.) for realizing the evaluation method of the present invention in the information processing device.
　更に、装置の分散・統合の具体的形態は図示するものに限られず、装置の全部または一部を、各種の付加または機能負荷に応じて、任意の単位で機能的または物理的に分散・統合して構成することができる。すなわち、上述した実施形態を任意に組み合わせて実施してもよく、上述した実施形態を選択的に実施してもよい。 Furthermore, the specific form of distributing/integrating the devices is not limited to the illustrated one, and all or part of the devices can be functionally or physically distributed/integrated in arbitrary units according to various additions or functional loads. can be configured as That is, the embodiments described above may be arbitrarily combined and implemented, or the embodiments described above may be selectively implemented.
　ＭＣＩと診断された６５歳以上の高齢者の血液サンプルおよびサンプル取得後９カ月～１５カ月経過時の認知症専門医による認知症診断情報を取得した（計８８例）。取得した認知症診断情報に従って、この８８例を、ＡＤ発症群（２３例）とＡＤ非発症群（６５例）に分類した。また、前述の測定方法（Ａ）を用いて、取得した血液サンプルから前記１９種のアミノ酸の血中濃度（ｎｍｏｌ／ｍｌ）を測定した。 We obtained blood samples from elderly people aged 65 and over who were diagnosed with MCI and dementia diagnosis information by dementia specialists 9 to 15 months after sample acquisition (total of 88 cases). According to the acquired dementia diagnostic information, these 88 cases were classified into an AD onset group (23 cases) and an AD non-onset group (65 cases). In addition, blood concentrations (nmol/ml) of the 19 amino acids were measured from the obtained blood samples using the measurement method (A) described above.
　ＡＤ非発症群とＡＤ発症群の血中濃度について帰無仮説を「両群の平均値が等しい」とした場合の検定（Ｗｅｌｃｈのｔ検定）において、ＡＤ非発症群に対して有意（ｐ値＜０．０５）な変動が認められた物質は、Ｈｉｓ、Ｉｌｅ、Ｌｅｕ、Ｌｙｓ、Ｔｙｒ、およびＶａｌであった。表１に、これら物質の血中濃度を用いた、サンプル取得後９カ月～１５カ月経過時のＡＤ非発症者とＡＤ発症者との鑑別における、ＲＯＣ曲線のＲＯＣ＿ＡＵＣの値を示す。各物質に対応するＲＯＣ＿ＡＵＣの値は高いことから、これら物質は、ＭＣＩと診断された者を対象とした「ＡＤを将来発症するリスクの評価（例えば、ＡＤを将来発症するリスクが高いか低いかの２群判別、など）」に有用である。 In the test (Welch's t-test) when the null hypothesis for the blood concentration of the AD non-onset group and the AD onset group is "equal mean values for both groups", significant (p value <0.05) variation was observed for His, Ile, Leu, Lys, Tyr, and Val. Table 1 shows the ROC_AUC values of the ROC curve in discriminating between AD non-developers and AD developpers 9 to 15 months after sample acquisition using the blood concentrations of these substances. Since the ROC_AUC value corresponding to each substance is high, these substances can be used for "assessment of the risk of developing AD in the future (e.g., whether the risk of developing AD in the future is high or low)" for those diagnosed with MCI. 2 group discrimination, etc.)”.
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000001
　実施例１で得られたサンプルデータを用いた。血漿中のアミノ酸濃度値が代入される変数を含む、ＡＤ非発症群とＡＤ発症群との２群を判別するための多変量判別式（多変量関数）を求めた。 The sample data obtained in Example 1 was used. A multivariate discriminant (multivariate function) for discriminating between two groups, an AD non-onset group and an AD onset group, including variables into which plasma amino acid concentration values are substituted, was determined.
　多変量判別式としてロジスティック回帰式を用いた。ロジスティック回帰式に含める２個の変数の組み合わせを前記１９種類のアミノ酸の血漿中濃度値から探索し、ＡＤ非発症群とＡＤ発症群の判別能が良好なロジスティック回帰式の探索を実施した。 A logistic regression formula was used as the multivariate discriminant. A combination of two variables to be included in the logistic regression formula was searched from the plasma concentration values of the 19 kinds of amino acids, and a search for a logistic regression formula with good ability to discriminate between the AD non-onset group and the AD onset group was performed.
　ＡＤ非発症群とＡＤ発症群の判別におけるＲＯＣ＿ＡＵＣ値が０．６００以上であった１２１個のロジスティック回帰式（式に含まれる変数の個数は２個）の一覧を、以下の［１．アミノ酸を含む２変数の式］に示した。これら１２１個のロジスティック回帰式に対応するＲＯＣ＿ＡＵＣ値は高いことから、これら１２１個のロジスティック回帰式は、実施例１に記載した評価に有用であると考えられる。なお、以下の［１．アミノ酸を含む２変数の式］には、各式に関して、式に含まれる変数とＲＯＣ＿ＡＵＣ値が示されている（以下同様）。 The list of 121 logistic regression formulas (the number of variables included in the formula is 2) that had a ROC_AUC value of 0.600 or more in discriminating between the AD non-onset group and the AD onset group is shown below in [1. A two-variable formula including amino acids]. Since the ROC_AUC values corresponding to these 121 logistic regression equations are high, it is believed that these 121 logistic regression equations are useful for the evaluation described in Example 1. Note that the following [1. Two-variable formula including amino acids] shows the variables included in the formula and the ROC_AUC value for each formula (the same applies hereinafter).
　実施例１で用いたサンプルデータを用いた。血漿中のアミノ酸濃度値が代入される変数を含む、ＡＤ非発症群とＡＤ発症群との２群を判別するための多変量判別式（多変量関数）を求めた。 The sample data used in Example 1 was used. A multivariate discriminant (multivariate function) for discriminating between two groups, an AD non-onset group and an AD onset group, including variables into which plasma amino acid concentration values are substituted, was determined.
　多変量判別式としてロジスティック回帰式を用いた。ロジスティック回帰式に含める３個の変数の組み合わせを前記１９種類のアミノ酸の血漿中濃度値から探索し、ＡＤ非発症群とＡＤ発症群の判別能が良好なロジスティック回帰式の探索を実施した。 A logistic regression formula was used as the multivariate discriminant. A combination of three variables to be included in the logistic regression formula was searched from the plasma concentration values of the 19 amino acids, and a search for a logistic regression formula with good ability to discriminate between the AD non-development group and the AD development group was performed.
　ＡＤ非発症群とＡＤ発症群の判別におけるＲＯＣ＿ＡＵＣ値が０．６５０以上であった５７３個のロジスティック回帰式（式に含まれる変数の個数は３個）の一覧を、以下の［２．アミノ酸を含む３変数の式］に示した。これら５７３個のロジスティック回帰式に対応するＲＯＣ＿ＡＵＣ値は高いことから、これら５７３個のロジスティック回帰式は、実施例１に記載した評価に有用であると考えられる。 The list of 573 logistic regression formulas (the number of variables included in the formula is 3) that had a ROC_AUC value of 0.650 or more in discriminating between the AD non-onset group and the AD onset group is shown below in [2. Three-variable formula including amino acids]. Since the ROC_AUC values corresponding to these 573 logistic regression equations are high, these 573 logistic regression equations are considered useful for the evaluation described in Example 1.
　実施例１で用いたサンプルデータを用いた。血漿中のアミノ酸濃度値が代入される変数を含む、ＡＤ非発症群とＡＤ発症群との２群を判別するための多変量判別式（多変量関数）を求めた。 The sample data used in Example 1 was used. A multivariate discriminant (multivariate function) for discriminating between two groups, an AD non-onset group and an AD onset group, including variables into which plasma amino acid concentration values are substituted, was determined.
　多変量判別式としてロジスティック回帰式を用いた。ロジスティック回帰式に含める４個の変数の組み合わせを前記１９種類のアミノ酸の血漿中濃度値から探索し、ＡＤ非発症群とＡＤ発症群の判別能が良好なロジスティック回帰式の探索を実施した。 A logistic regression formula was used as the multivariate discriminant. Combinations of four variables to be included in the logistic regression equation were searched from the plasma concentration values of the 19 amino acids, and a search for a logistic regression equation with good ability to discriminate between the AD non-onset group and the AD onset group was performed.
　ＡＤ非発症群とＡＤ発症群の判別におけるＲＯＣ＿ＡＵＣ値が０．７２０以上であった７０８個のロジスティック回帰式（式に含まれる変数の個数は４個）の一覧を、以下の［３．アミノ酸を含む４変数の式］に示した。これら７０８個のロジスティック回帰式に対応するＲＯＣ＿ＡＵＣ値は高いことから、これら７０８個のロジスティック回帰式は、実施例１に記載した評価に有用であると考えられる。 The list of 708 logistic regression formulas (the number of variables included in the formula is 4) that had a ROC_AUC value of 0.720 or more in discriminating between the AD non-onset group and the AD onset group is shown below in [3. Four-variable formula including amino acids]. Since the ROC_AUC values corresponding to these 708 logistic regression equations are high, these 708 logistic regression equations are considered useful for the evaluation described in Example 1.
　実施例１で用いたサンプルデータを用いた。血漿中のアミノ酸濃度値が代入される変数を含む、ＡＤ非発症群とＡＤ発症群との２群を判別するための多変量判別式（多変量関数）を求めた。 The sample data used in Example 1 was used. A multivariate discriminant (multivariate function) for discriminating between two groups, an AD non-onset group and an AD onset group, including variables into which plasma amino acid concentration values are substituted, was determined.
　多変量判別式としてロジスティック回帰式を用いた。ロジスティック回帰式に含める５個の変数の組み合わせを前記１９種類のアミノ酸の血漿中濃度値から探索し、ＡＤ非発症群とＡＤ発症群の判別能が良好なロジスティック回帰式の探索を実施した。 A logistic regression formula was used as the multivariate discriminant. Combinations of five variables to be included in the logistic regression equation were searched from the plasma concentration values of the 19 kinds of amino acids, and a search for a logistic regression equation with good ability to discriminate between the AD non-onset group and the AD onset group was performed.
　ＡＤ非発症群とＡＤ発症群の判別におけるＲＯＣ＿ＡＵＣ値が０．７４０以上であった１００９個のロジスティック回帰式（式に含まれる変数の個数は５個）の一覧を、以下の［４．アミノ酸を含む５変数の式］に示した。これら１００９個のロジスティック回帰式に対応するＲＯＣ＿ＡＵＣ値は高いことから、これら１００９個のロジスティック回帰式は、実施例１に記載した評価に有用であると考えられる。 The list of 1009 logistic regression formulas (the number of variables included in the formula is 5) that had a ROC_AUC value of 0.740 or more in discriminating between the AD non-onset group and the AD onset group is shown below in [4. A five-variable formula including amino acids]. Since the ROC_AUC values corresponding to these 1009 logistic regression equations are high, it is believed that these 1009 logistic regression equations are useful for the evaluation described in Example 1.
　実施例１で得られたサンプルデータを用いた。血漿中のアミノ酸濃度値が代入される変数を含む、ＡＤ非発症群とＡＤ発症群との２群を判別するための多変量判別式（多変量関数）を求めた。 The sample data obtained in Example 1 was used. A multivariate discriminant (multivariate function) for discriminating between two groups, an AD non-onset group and an AD onset group, including variables into which plasma amino acid concentration values are substituted, was obtained.
　多変量判別式としてロジスティック回帰式を用いた。ロジスティック回帰式に含める６個の変数の組み合わせを前記１９種類のアミノ酸の血漿中濃度値から探索し、ＡＤ非発症群とＡＤ発症群の判別能が良好なロジスティック回帰式の探索を実施した。 A logistic regression formula was used as the multivariate discriminant. A combination of six variables to be included in the logistic regression formula was searched from the plasma concentration values of the 19 amino acids, and a search for a logistic regression formula with good ability to discriminate between the AD non-onset group and the AD onset group was performed.
　ＡＤ非発症群とＡＤ発症群の判別におけるＲＯＣ＿ＡＵＣ値が０．７５０以上であった１９６５個のロジスティック回帰式（式に含まれる変数の個数は６個）の一覧を、以下の［５．アミノ酸を含む６変数の式］に示した。これら１９６５個のロジスティック回帰式に対応するＲＯＣ＿ＡＵＣ値は高いことから、これら１９６５個のロジスティック回帰式は、実施例１に記載した評価に有用であると考えられる。 A list of 1965 logistic regression formulas (the number of variables included in the formula is 6) that had a ROC_AUC value of 0.750 or more in discriminating between the AD non-onset group and the AD onset group is shown below in [5. 6-variable formula including amino acids]. Since the ROC_AUC values corresponding to these 1965 logistic regression equations are high, these 1965 logistic regression equations are considered useful for the evaluation described in Example 1.
　実施例６に記載した１９６５個の式を基に、式における各アミノ酸変数の出現頻度を求めた。表２に、各アミノ酸変数の出現頻度の集計結果を示す。 Based on the 1965 formulas described in Example 6, the frequency of appearance of each amino acid variable in the formula was determined. Table 2 shows the results of counting the frequency of occurrence of each amino acid variable.
Figure JPOXMLDOC01-appb-T000002
Figure JPOXMLDOC01-appb-T000002
　これより、Ｉｌｅ、Ｇｌｎ、Ｔｙｒ、Ｌｙｓ、Ｈｉｓ、Ａｓｎ、Ｌｅｕ、Ｐｈｅ、およびＡｒｇの出現頻度は５００回以上と高いことが示された。特に、Ｉｌｅ、Ｇｌｎ、およびＴｙｒの出現頻度は１，０００回以上と高いことが示された。 From this, it was shown that Ile, Gln, Tyr, Lys, His, Asn, Leu, Phe, and Arg appear more frequently than 500 times. In particular, Ile, Gln, and Tyr appeared at a high frequency of 1,000 or more.
　更に、式における２種類のアミノ酸変数の組み合わせの出現頻度を求めた。表３に、各組み合わせの出現頻度の集計結果を示す。 Furthermore, we calculated the appearance frequency of the combination of the two types of amino acid variables in the formula. Table 3 shows the count results of the frequency of appearance of each combination.
Figure JPOXMLDOC01-appb-T000003
Figure JPOXMLDOC01-appb-T000003
　これより、以下の２種類のアミノ酸変数の組み合わせの出現頻度は１００回以上と高いことが示された。
Gln, Ile; Ile, Tyr; His, Ile; Ile, Lys; Gln, Tyr; Asn, Ile; Gln, His; Ile, Phe; Leu, Tyr; Gln, Leu; Arg, Ile; Gln, Lys; Phe, Tyr; Cit, Ile; Lys, Tyr; His, Tyr; Asn, Tyr; Asn, Lys; Gln, Phe; Asn, Gln; Gly, Ile; Arg, Lys; Ile, Met; Ile, Leu; Gln, Gly; Gly, Tyr; Asn, Leu; Ile, Trp; Asn, His; Leu, Phe; Gln, Trp; Arg, Tyr; Cit, Tyr; Leu, Lys; Ile, Orn; Cit, Gln; Met, Tyr; Arg, Gln; His, Phe; Ile, Thr; Lys, Phe; Trp, Tyr; Ile, Ser; Gln, Val; Ile, Val; Gln, Orn; Ala, Ile; Gln, Met; Asn, Cit; Asn, Phe; Gln, Ser; Ile, Pro; His, Leu; Tyr, Val; Orn, Tyr; Arg, Asn; His, Lys; Ser, Tyr; Gln, Thr; His, Met; Cit, Lys; Ala, Gln; Arg, His; Gly, Lys; Cit, His; Thr, Tyr; Asn, Gly; Arg, Phe; Pro, Tyr; Lys, Trp; Gly, Leu; Gln, Pro; Lys, Met; Ala, Tyr; Arg, Leu; His, Trp; His, Orn; Leu, Trp; Lys, Val; Lys, Orn; His, Val; Asn, Orn; Gly, His; Lys, Thr; Cit, Leu; Ala, His; Asn, Met; Lys, Ser; Phe, Thr; His, Pro; Leu, Orn; Cit, Phe; Cit, Gly; Asn, Val; His, Ser; Gly, Phe; Leu, Met; Asn, Trp; Met, Phe; Asn, Thr; His, Thr; Orn, Phe; Phe, Trp From this, it was shown that the frequency of appearance of the combination of the following two types of amino acid variables is as high as 100 times or more.
Gln, Ile; Ile, Tyr; His, Ile; Ile, Lys; Gln, Tyr; Tyr; Cit, Ile; Lys, Tyr; His, Tyr; Asn, Tyr; Gly, Tyr; Asn, Leu; Ile, Trp; Asn, His; Leu, Phe; Gln, Trp; Gln; His, Phe; Ile, Thr; Lys, Phe; Trp, Tyr; Gln, Ser; Ile, Pro; His, Leu; Tyr, Val; Orn, Tyr; His; Gly, Lys; Cit, His; Thr, Tyr; Asn, Gly; His, Trp; His, Orn; Leu, Trp; Lys, Val; Lys, Orn; His, Val; Asn, Orn; Ser; Phe, Thr; His, Pro; Leu, Orn; Cit, Phe; His, Thr; Orn, Phe; Phe, Trp
　特に、以下の２種類のアミノ酸変数の組み合わせの出現頻度は５００回以上と高いことが示された。
Gln, Ile; Ile, Tyr; His, Ile; Ile, Lys; Gln, Tyr; Asn, Ile; Gln, His; Ile, Phe In particular, it was shown that the frequency of occurrence of combinations of the following two types of amino acid variables is as high as 500 times or more.
Gln, Ile; Ile, Tyr; His, Ile; Ile, Lys; Gln, Tyr;
　式における出現頻度が高かった前記の単体のアミノ酸変数および２種類のアミノ酸変数の組み合わせは、実施例１に記載した評価に有用であると考えられる。 The single amino acid variable and the combination of two types of amino acid variables that appear frequently in the formula are considered useful for the evaluation described in Example 1.
　実施例１で得られた血液サンプルおよび認知症診断結果ならびに実施例１で測定された前記１９種類のアミノ酸の血中濃度（ｎｍｏｌ／ｍｌ）を用いた（計８８例）。なお、実施例１に記載の通り、この８８例は、ＡＤ発症群（２３例）とＡＤ非発症群（６５例）に分類された。血液サンプルから全血サンプルを取得し、半導体レーザーを使用したフローサイトメトリー法により全血中の白血球数（／μＬ）を、シースフロー直流電流検出方式により全血中の赤血球数（×１０４／μＬ）を、ＳＬＳ－ヘモグロビン法により全血中の血色素量（ｇ／ｄＬ）を、赤血球パルス波高値検出法により全血中のヘマトクリット値（％）を測定した。また、血液サンプルから血清サンプルを取得し、化学発光酵素免疫測定法により血清中の葉酸濃度（ｎｇ／ｍＬ）を、直接法により血清中のＬＤＬ－コレステロール濃度（ｍｇ／ｄＬ）を、ＢＣＰ改良法により血清中のアルブミン濃度（ｇ／ｄＬ）を、免疫比濁法により血清中のプレアルブミン濃度（ｍｇ／ｄＬ）を、ラテックス免疫比濁法により血清中のＣ反応性蛋白濃度（ｍｇ／ｄＬ）を、酵素法により血清中の中性脂肪濃度（ｍｇ／ｄＬ）を、ウリカーゼＰＯＤ法により血清中の尿酸濃度（ｍｇ／ｄＬ）を測定した。 The blood samples and dementia diagnosis results obtained in Example 1 and the blood concentrations (nmol/ml) of the 19 amino acids measured in Example 1 were used (total of 88 cases). As described in Example 1, these 88 cases were classified into an AD onset group (23 cases) and an AD non-onset group (65 cases). A whole blood sample is obtained from the blood sample, the white blood cell count (/μL) in the whole blood is determined by flow cytometry using a semiconductor laser, and the red blood cell count (×10 4 /μL) in the whole blood is determined by the sheath flow direct current detection method. μL), the hemoglobin amount (g/dL) in whole blood was measured by the SLS-hemoglobin method, and the hematocrit value (%) in whole blood was measured by the erythrocyte pulse peak value detection method. In addition, a serum sample was obtained from the blood sample, and the folic acid concentration (ng/mL) in the serum was measured by the chemiluminescent enzyme immunoassay method, the LDL-cholesterol concentration (mg/dL) in the serum was measured by the direct method, and the improved BCP method was used. Serum albumin concentration (g/dL) by immunonephelometry, serum prealbumin concentration (mg/dL) by immunoturbidimetry, serum C-reactive protein concentration (mg/dL) by latex immunoturbidimetry were measured for triglyceride concentration (mg/dL) in serum by the enzymatic method and uric acid concentration (mg/dL) in serum by the uricase POD method.
　アミノ酸の血漿中濃度値が代入される変数と検査項目の検査値または身体特徴の特徴値が代入される変数を含む、ＡＤ非発症群とＡＤ発症群との２群を判別するための多変量判別式（多変量関数）を求めた。 A multivariate for discriminating two groups, an AD non-onset group and an AD onset group, including a variable to which a plasma concentration value of an amino acid is substituted and a variable to which a test value of a test item or a characteristic value of a physical characteristic is substituted. A discriminant (multivariate function) was obtained.
　多変量判別式としてロジスティック回帰式を用いた。ロジスティック回帰式に含める４個の変数の組み合わせを、前記１９種類のアミノ酸の血漿中濃度値から３個の血漿中濃度値を選択し、下記グループ１から１個の検査値または特徴値を選択するという条件で探索し、ＡＤ非発症群とＡＤ発症群の判別能が良好なロジスティック回帰式の探索を実施した。なお、グループ１は、体重（ｋｇ）、ＢＭＩ（ｋｇ／ｍ２）、全血中の白血球数（ＷＢＣ）、全血中の赤血球数（ＲＢＣ）、全血中の血色素量（Ｈｂ）、全血中のヘマトクリット値（Ｈｔ）、血清中の葉酸濃度（葉酸）、血清中のＬＤＬ－コレステロール濃度（ＬＤＬＣ）、血清中のアルブミン濃度（Ａｌｂ）、血清中のプレアルブミン濃度（プレアルブミン）、血清中のＣ反応性蛋白濃度（ＣＲＰ）、血清中の中性脂肪濃度（ＴＧ）、および血清中の尿酸の濃度（尿酸）から構成される。 A logistic regression equation was used as the multivariate discriminant. For combinations of four variables to be included in the logistic regression equation, three plasma concentration values are selected from the above-described 19 amino acid plasma concentration values, and one test value or characteristic value is selected from Group 1 below. Under these conditions, a search was made for a logistic regression formula with good ability to discriminate between the AD non-onset group and the AD onset group. In Group 1, body weight (kg), BMI (kg/m 2 ), white blood cell count in whole blood (WBC), red blood cell count in whole blood (RBC), hemoglobin content in whole blood (Hb), total Blood hematocrit value (Ht), serum folic acid concentration (folic acid), serum LDL-cholesterol concentration (LDLC), serum albumin concentration (Alb), serum prealbumin concentration (prealbumin), serum It consists of C-reactive protein concentration (CRP) in serum, triglyceride concentration (TG), and concentration of uric acid in serum (uric acid).
　得られたロジスティック回帰式のうち、ＡＤ非発症群とＡＤ発症群の判別におけるＲＯＣ＿ＡＵＣ値が前記１９種類のアミノ酸以外の変数を組み込むことで上昇した式の数と、割合を表４に示す。 Among the obtained logistic regression formulas, Table 4 shows the number and percentage of formulas in which the ROC_AUC value in discriminating between the AD non-onset group and the AD onset group increased by incorporating variables other than the 19 types of amino acids.
Figure JPOXMLDOC01-appb-T000004
Figure JPOXMLDOC01-appb-T000004
　前記１９種類のアミノ酸の血漿中濃度値から選択した３個の血漿中濃度値の組み合わせは９６９通りであるが、この９６９通りの組み合わせに、ＬＤＬＣ、ＲＢＣ、ＣＲＰ、プレアルブミン、Ｈｔ、Ｈｂ、ＢＭＩ、ＷＢＣ、葉酸、ＴＧ、尿酸、体重、およびＡｌｂのうちのいずれか１個の変数を追加することにより、７０％以上（６７９通り以上）の式でＲＯＣ＿ＡＵＣ値が上昇した。このことから、これら１３個の変数のうちのいずれか１個の変数を式に加えることで、実施例１に記載した評価における式の有用性が高くなると考えられる。 There are 969 combinations of three plasma concentration values selected from the plasma concentration values of the 19 amino acids. , WBC, folic acid, TG, uric acid, body weight, and Alb increased ROC_AUC values in more than 70% (>679 ways) of formulas. From this, it is considered that adding any one of these 13 variables to the equation increases the usefulness of the equation in the evaluation described in Example 1.
　特に、前記の９６９通りの組み合わせに、ＬＤＬＣ、ＲＢＣ、ＣＲＰ、プレアルブミン、Ｈｔ、Ｈｂ、ＢＭＩ、およびＷＢＣのうちのいずれか１個の変数を追加することにより、９０％以上（８７３通り以上）の式でＲＯＣ＿ＡＵＣ値が上昇した。このことから、これら８個の変数のうちのいずれか１個の変数を式に加えることで、実施例１に記載した評価における式の有用性がさらに高くなると考えられる。 In particular, by adding any one variable of LDLC, RBC, CRP, prealbumin, Ht, Hb, BMI, and WBC to the 969 combinations, 90% or more (873 or more) The ROC_AUC value increased with the formula of From this, it is believed that adding any one of these eight variables to the equation further increases the usefulness of the equation in the evaluation described in Example 1.
　実施例１で得られた血液サンプルおよび認知症診断結果、実施例１で測定された前記１９種類のアミノ酸の血中濃度（ｎｍｏｌ／ｍｌ）、ならびに実施例７で測定された１１種類の検査項目の検査値および２種類の身体特徴の特徴値を用いた（計８８例）。なお、実施例１に記載の通り、この８８例は、ＡＤ発症群（２３例）とＡＤ非発症群（６５例）に分類された。血液サンプルから血清サンプルを取得し、ＪＳＣＣ標準化対応法により血清中のγＧＴＰ濃度（Ｕ／Ｌ）を測定した。 Blood samples and dementia diagnosis results obtained in Example 1, blood concentrations (nmol/ml) of the 19 amino acids measured in Example 1, and 11 test items measured in Example 7 and two types of physical feature values were used (total of 88 cases). As described in Example 1, these 88 cases were classified into an AD onset group (23 cases) and an AD non-onset group (65 cases). A serum sample was obtained from the blood sample, and the γGTP concentration (U/L) in serum was measured according to the JSCC standardized method.
　血漿中のアミノ酸濃度値が代入される変数と一般生化学指標の検査値または身体特徴の特徴値が代入される変数を含む、ＡＤ非発症群とＡＤ発症群との２群を判別するための多変量判別式（多変量関数）を求めた。 A method for discriminating two groups, an AD non-onset group and an AD onset group, including a variable to which a plasma amino acid concentration value is substituted and a variable to which a test value of a general biochemical index or a characteristic value of a physical characteristic is substituted. A multivariate discriminant (multivariate function) was obtained.
　多変量判別式としてロジスティック回帰式を用いた。ロジスティック回帰式に含める５個の変数の組み合わせを、前記１９種類のアミノ酸の血漿中濃度値から４個の血漿中濃度値を選択し、下記グループ２から１個の検査値または特徴値を選択するという条件で探索し、ＡＤ非発症群とＡＤ発症群の判別能が良好なロジスティック回帰式の探索を実施した。なお、グループ２は、実施例７に記載したグループ１に血清中のγＧＴＰ濃度（γＧＴＰ）が加わったグループである。 A logistic regression formula was used as the multivariate discriminant. For combinations of five variables to be included in the logistic regression equation, four plasma concentration values are selected from the plasma concentration values of the above 19 amino acids, and one test value or characteristic value is selected from Group 2 below. Under these conditions, a search for a logistic regression formula with a good ability to discriminate between the AD non-onset group and the AD onset group was performed. Group 2 is a group obtained by adding serum γGTP concentration (γGTP) to Group 1 described in Example 7.
　得られたロジスティック回帰式のうち、ＡＤ非発症群とＡＤ発症群の判別におけるＲＯＣ＿ＡＵＣ値が前記１９種類のアミノ酸以外の変数を組み込むことで上昇した式の数と、割合を表５に示す。 Among the obtained logistic regression formulas, Table 5 shows the number and percentage of formulas in which the ROC_AUC value in discriminating between the AD non-onset group and the AD onset group increased by incorporating variables other than the 19 types of amino acids.
Figure JPOXMLDOC01-appb-T000005
Figure JPOXMLDOC01-appb-T000005
　前記１９種類のアミノ酸の血漿中濃度値から選択した４個の血漿中濃度値の組み合わせは３，８７６通りであるが、この３，８７６通りの組み合わせに、ＬＤＬＣ、ＲＢＣ、ＣＲＰ、プレアルブミン、Ｈｔ、Ｈｂ、ＢＭＩ、ＷＢＣ、葉酸、ＴＧ、尿酸、Ａｌｂ、体重、およびγＧＴＰのうちのいずれか１個の変数を追加することにより、７０％以上（２，７１４通り以上）の式でＲＯＣ＿ＡＵＣ値が上昇した。このことから、これら１４個の変数のうちのいずれか１個の変数を式に加えることで、実施例１に記載した評価における式の有用性が高くなると考えられる。 There are 3,876 combinations of four plasma concentration values selected from the plasma concentration values of the 19 amino acids. , Hb, BMI, WBC, folic acid, TG, uric acid, Alb, body weight, and γGTP, the ROC_AUC value was found to be Rose. From this, it is considered that adding any one of these 14 variables to the equation increases the usefulness of the equation in the evaluation described in Example 1.
　特に、前記の３，８７６通りの組み合わせに、ＬＤＬＣ、ＲＢＣ、ＣＲＰ、プレアルブミン、Ｈｔ、Ｈｂ、ＢＭＩ、およびＷＢＣのうちのいずれか１個の変数を追加することにより、９０％以上（３，４８９通り以上）の式でＲＯＣ＿ＡＵＣ値が上昇した。このことから、これらの８個の変数のうちのいずれか１個の変数を式に加えることで、実施例１に記載した評価における式の有用性がさらに高くなると考えられる。 In particular, by adding any one variable of LDLC, RBC, CRP, prealbumin, Ht, Hb, BMI, and WBC to the 3,876 combinations, more than 90% (3, 489 or more) equations increased ROC_AUC values. From this, it is believed that adding any one of these eight variables to the equation further increases the usefulness of the equation in the evaluation described in Example 1.
　実施例１で得られた血液サンプルおよび認知症診断結果、実施例１で測定された前記１９種類のアミノ酸の血中濃度（ｎｍｏｌ／ｍｌ）、実施例７で測定された１１種類の検査項目の検査値および２種類の身体特徴の特徴値、ならびに実施例８で測定された１種類の検査項目の検査値を用いた（計８８例）。なお、実施例１に記載の通り、この８８例は、ＡＤ発症群（２３例）とＡＤ非発症群（６５例）に分類された。血液サンプルから全血サンプルを取得し、ラテックス凝集法により全血中のヘモグロビンＡ１ｃ（％）を測定した。 Blood samples and dementia diagnosis results obtained in Example 1, blood concentrations (nmol/ml) of the 19 amino acids measured in Example 1, and 11 test items measured in Example 7 The test values, the characteristic values of two types of physical characteristics, and the test values of one type of test item measured in Example 8 were used (total of 88 cases). As described in Example 1, these 88 cases were classified into an AD onset group (23 cases) and an AD non-onset group (65 cases). A whole blood sample was obtained from the blood samples, and hemoglobin A1c (%) in the whole blood was measured by the latex agglutination method.
　血漿中のアミノ酸濃度値が代入される変数と一般生化学指標の検査値または身体特徴の特徴値が代入される変数を含む、ＡＤ非発症群とＡＤ発症群との２群を判別するための多変量判別式（多変量関数）を求めた。 A method for discriminating two groups, an AD non-onset group and an AD onset group, including a variable to which a plasma amino acid concentration value is substituted and a variable to which a test value of a general biochemical index or a characteristic value of a physical characteristic is substituted. A multivariate discriminant (multivariate function) was obtained.
　多変量判別式としてロジスティック回帰式を用いた。ロジスティック回帰式に含める６個の変数の組み合わせを、前記１９種類のアミノ酸の血漿中濃度値から５個の血漿中濃度値を選択し、下記グループ３から１個の検査値または特徴値を選択するという条件で探索し、ＡＤ非発症群とＡＤ発症群の判別能が良好なロジスティック回帰式の探索を実施した。なお、グループ３は、実施例８に記載したグループ２を構成する、体重を除く残り１３個の要素および全血中のヘモグロビンＡ１ｃ（ＨｂＡ１ｃ）で構成されるグループである。 A logistic regression formula was used as the multivariate discriminant. A combination of 6 variables to be included in the logistic regression equation is selected from the plasma concentration values of the 19 amino acids described above, and 5 plasma concentration values are selected, and 1 test value or characteristic value is selected from Group 3 below. Under these conditions, a search for a logistic regression formula with a good ability to discriminate between the AD non-onset group and the AD onset group was performed. Group 3 is a group composed of the remaining 13 elements excluding body weight and hemoglobin A1c (HbA1c) in whole blood, which constitute Group 2 described in Example 8.
　得られたロジスティック回帰式のうち、ＡＤ非発症群とＡＤ発症群の判別におけるＲＯＣ＿ＡＵＣ値が前記１９種類のアミノ酸以外の変数を組み込むことで上昇した式の数と、割合を表６に示す。 Among the obtained logistic regression formulas, Table 6 shows the number and percentage of formulas in which the ROC_AUC value in discriminating between the AD non-onset group and the AD onset group increased by incorporating variables other than the 19 types of amino acids.
Figure JPOXMLDOC01-appb-T000006
Figure JPOXMLDOC01-appb-T000006
　前記１９種類のアミノ酸の血漿中濃度値から選択した５個の血漿中濃度値の組み合わせは１１，６２８通りであるが、この１１，６２８通りの組み合わせに、ＬＤＬＣ、ＲＢＣ、ＣＲＰ、プレアルブミン、Ｈｔ、Ｈｂ、ＢＭＩ、ＷＢＣ、葉酸、ＴＧ、尿酸、Ａｌｂ、γＧＹＰ、およびＨｂＡ１ｃのうちのいずれか１個の変数を追加することにより、７０％以上（８，１４０通り以上）の式でＲＯＣ＿ＡＵＣ値が上昇した。このことから、これら１４個の変数のうちのいずれか１個の変数を式に加えることで、実施例１に記載した評価における式の有用性が高くなると考えられる。 There are 11,628 combinations of five plasma concentration values selected from the plasma concentration values of the 19 amino acids. , Hb, BMI, WBC, folic acid, TG, uric acid, Alb, γGYP, and HbA1c, the ROC_AUC value was reduced to Rose. From this, it is considered that adding any one of these 14 variables to the equation increases the usefulness of the equation in the evaluation described in Example 1.
　特に、前記の１１，６２８通りの組み合わせに、ＬＤＬＣ、ＲＢＣ、ＣＲＰ、プレアルブミン、Ｈｔ、およびＨｂのうちのいずれか１個の変数を追加することにより、９０％以上（１０，４６６通り以上）の式でＲＯＣ＿ＡＵＣ値が上昇した。このことから、これら６個の変数のうちのいずれか１個の変数を式に加えることで、実施例１に記載した評価における式の有用性がさらに高くなると考えられる。 In particular, by adding any one variable of LDLC, RBC, CRP, prealbumin, Ht, and Hb to the 11,628 combinations, 90% or more (10,466 or more) The ROC_AUC value increased with the formula of From this, it is believed that adding any one of these six variables to the formula further increases the usefulness of the formula in the evaluation described in Example 1.
　ＭＣＩと診断された５０歳以上の高齢者の血液サンプルおよびサンプル取得後９カ月～１５カ月経過時の認知症専門医による認知症診断情報を取得した（計１５１例）。取得した認知症診断情報に従って、この１５１例を、ＡＤ発症群（３３例）とＡＤ非発症群（１１８例）に分類した。血液サンプルから前述の測定方法（Ｄ）を用いて、回収率、ピーク形状、安定性の観点から定量可能であり、かつサンプルの過半数（５９例）以上において定量下限濃度以上の濃度が測定された１０種類のアミノ酸関連代謝物（3h-Kyn、5h-Indole-3-acetic acid、Anthranilic acid、Indole-3-acetic acid、Indole-3-lactic acid、Kynurenic acid、Picolinic acid、Quinolinic acid、Xanthurenic acid、およびNeopterin）の血中濃度（ｎｍｏｌ／ｍｌ）を測定した。さらに前述の測定方法（Ａ）を用いて、回収率、ピーク形状、安定性の観点から定量可能であり、かつサンプルの過半数（５９例）以上において定量下限濃度以上の濃度が測定された１５種類のアミノ酸関連代謝物（1-Mehis、3-Mehis、aABA、ADMA、b-AiBA、cystathionine、GABA、hArg、Kyn、N6-acetyl-L-lysine、N8-acetyl-spd、SDMA、serotonin、Spd、およびthioproline）の血中濃度（ｎｍｏｌ／ｍｌ）を測定した。 We obtained blood samples from elderly people aged 50 and over who were diagnosed with MCI and dementia diagnosis information by dementia specialists 9 to 15 months after sample acquisition (total of 151 cases). According to the acquired dementia diagnostic information, these 151 cases were classified into an AD onset group (33 cases) and an AD non-onset group (118 cases). From the blood sample, using the above-mentioned measurement method (D), it was possible to quantify from the viewpoint of recovery, peak shape, and stability, and more than half of the samples (59 cases) had a concentration equal to or higher than the lower limit of quantitation. 10 amino acid-related metabolites (3h-Kyn, 5h-Indole-3-acetic acid, Anthranilic acid, Indole-3-acetic acid, Indole-3-lactic acid, Kynurenic acid, Picolinic acid, Quinolinic acid, Xanthurenic acid, and Neopterin) blood concentrations (nmol/ml) were measured. Furthermore, 15 types that can be quantified from the viewpoint of recovery rate, peak shape, and stability using the above-described measurement method (A), and that concentrations above the lower limit of quantification concentration were measured in more than half of the samples (59 cases). amino acid-related metabolites of and thioproline) were measured in blood (nmol/ml).
　アミノ酸関連代謝物の血中濃度は正規分布に従わないと仮定し、ＡＤ非発症群とＡＤ発症群の血中濃度について帰無仮説を「両群の中央値が等しい」とした場合の検定（Mann-WhitneyのU検定）において、ＡＤ非発症群に対して有意（ｐ値＜０．０５）な変動が認められた物質は、Indole-3-lactic acid、ADMA、hArg、およびKynであった。表７に、これら物質の血中濃度を用いた、サンプル取得後９カ月～１５カ月経過時のＡＤ非発症者とＡＤ発症者との鑑別における、ＲＯＣ曲線のＲＯＣ＿ＡＵＣの値を示す。各物質に対応するＲＯＣ＿ＡＵＣの値は高いことから、これら物質は、実施例１に記載した評価に有用である。 Assuming that the blood concentration of amino acid-related metabolites does not follow a normal distribution, the test when the null hypothesis for the blood concentration of the AD non-onset group and the AD onset group is "the median values of both groups are equal" ( Mann-Whitney U test), the substances that showed significant (p-value < 0.05) variation with respect to the non-AD group were Indole-3-lactic acid, ADMA, hArg, and Kyn. . Table 7 shows the ROC_AUC values of the ROC curve in discriminating between AD non-developers and AD developpers 9 to 15 months after sample acquisition using the blood concentrations of these substances. These substances are useful for the evaluation described in Example 1 because the ROC_AUC values corresponding to each substance are high.
Figure JPOXMLDOC01-appb-T000007
Figure JPOXMLDOC01-appb-T000007
　ＭＣＩと診断された５０歳以上の高齢者１６４例および認知機能健常と診断された５０歳以上の高齢者２例の血液サンプル、およびサンプル取得後９カ月～２４カ月経過時の認知症専門医による認知症診断情報を取得した（計１６６例）。取得した認知症診断情報に従って、この１６６例を、認知症発症群（ＡＤ発症３５例、ＤＬＢ発症２例、計３７例）と認知症非発症群（１２９例）に分類した。ここで、認知症非発症とは、診断時点でＭＣＩもしくは認知機能健常のいずれかの状態であったことをいう。また、前述の測定方法（Ａ）を用いて、取得した血液サンプルから前記１９種のアミノ酸の血中濃度（ｎｍｏｌ／ｍｌ）を測定した。 Blood samples from 164 people aged 50 years or older diagnosed with MCI and 2 people aged 50 years or older diagnosed with normal cognitive function, and cognition by dementia specialists 9 months to 24 months after sample collection Disease diagnosis information was acquired (total of 166 cases). According to the acquired dementia diagnostic information, these 166 cases were classified into a dementia onset group (AD onset: 35 cases, DLB onset: 2 cases, total 37 cases) and a dementia non-onset group (129 cases). Here, dementia non-onset refers to having either MCI or healthy cognitive function at the time of diagnosis. In addition, blood concentrations (nmol/ml) of the 19 amino acids were measured from the obtained blood samples using the measurement method (A) described above.
　測定したサンプルデータについて、前記１９種類のアミノ酸のうち２個を変数として含む、実施例２に記載した多変量のロジスティック回帰式（多変量関数）を当てはめ、認知症発症群と認知症非発症群の判別能を評価した。ここで、多変量ロジスティック回帰式の当てはめとは、実施例２に記載した多変量ロジスティック回帰式のアミノ酸値に当該サンプルデータを代入することをいう。判別能の評価にはＲＯＣ＿ＡＵＣを用いた。 For the measured sample data, applying the multivariate logistic regression equation (multivariate function) described in Example 2, including two of the 19 types of amino acids as variables, dementia onset group and dementia non-onset group was evaluated. Here, the fitting of the multivariate logistic regression formula means substituting the sample data into the amino acid values of the multivariate logistic regression formula described in Example 2. ROC_AUC was used for evaluation of discrimination ability.
　これらのロジスティック回帰式（式に含まれる変数の個数は２個）のＲＯＣ＿ＡＵＣの一覧を、以下の［６．アミノ酸を含む２変数の式］に示した。これら１２１個のロジスティック回帰式に対応するＲＯＣ＿ＡＵＣ値は最も低いものでも０．５５以上と高いことから、これらのロジスティック回帰式は、認知症を発症していない者の集団を対象とした「認知症を将来発症するリスクの評価（例えば、認知症を将来発症するリスクが高いか低いかの２群判別、など）」に有用である。なお、以下の［６．アミノ酸を含む２変数の式］には、各式に関して、式に含まれる変数と、実施例２におけるＲＯＣ＿ＡＵＣ値と、実施例１１におけるＲＯＣ＿ＡＵＣ値と、後述する実施例１６における偽陽性率と、が示されている。 The list of ROC_AUC of these logistic regression formulas (the number of variables included in the formula is 2) is shown in [6. A two-variable formula including amino acids]. Since the ROC_AUC value corresponding to these 121 logistic regression equations is as high as 0.55 or more even at the lowest, these logistic regression equations It is useful for evaluating the risk of developing dementia in the future (for example, 2-group discrimination as to whether the risk of developing dementia in the future is high or low). Note that the following [6. Two-variable formula containing amino acids], for each formula, the variables included in the formula, the ROC_AUC value in Example 2, the ROC_AUC value in Example 11, and the false positive rate in Example 16 described later. It is shown.
　実施例１１で用いたサンプルデータを用いた。前記１９種類のアミノ酸のうち３個を変数として含む、実施例３に記載した多変量のロジスティック回帰式（多変量関数）を当てはめ、認知症発症群と認知症非発症群の判別能を評価した。ここで、多変量ロジスティック回帰式の当てはめとは、実施例３に記載した多変量ロジスティック回帰式のアミノ酸値に当該サンプルデータを代入することをいう。判別能の評価にはＲＯＣ＿ＡＵＣを用いた。 The sample data used in Example 11 was used. The multivariate logistic regression equation (multivariate function) described in Example 3, which includes 3 of the 19 types of amino acids as variables, was applied to evaluate the discriminative ability between the dementia onset group and the dementia non-onset group. . Here, the fitting of the multivariate logistic regression formula means substituting the sample data into the amino acid values of the multivariate logistic regression formula described in Example 3. ROC_AUC was used for evaluation of discrimination ability.
　これらのロジスティック回帰式（式に含まれる変数の個数は３個）のＲＯＣ＿ＡＵＣの一覧を、以下の［７．アミノ酸を含む３変数の式］に示した。これら５７３個のロジスティック回帰式に対応するＲＯＣ＿ＡＵＣ値は最も低いものでも０．５７以上と高いことから、これらのロジスティック回帰式は、実施例１１に記載した評価に有用である。なお、以下の［７．アミノ酸を含む３変数の式］には、各式に関して、式に含まれる変数と、実施例３におけるＲＯＣ＿ＡＵＣ値と、実施例１２におけるＲＯＣ＿ＡＵＣ値と、後述する実施例１７における偽陽性率と、が示されている。 The list of ROC_AUC of these logistic regression formulas (the number of variables included in the formula is 3) is shown in [7. Three-variable formula including amino acids]. These logistic regression equations are useful for the evaluation described in Example 11 because the ROC_AUC values corresponding to these 573 logistic regression equations are as high as 0.57 or more, even at the lowest. In addition, the following [7. Three-variable formula containing amino acids], for each formula, the variables included in the formula, the ROC_AUC value in Example 3, the ROC_AUC value in Example 12, and the false positive rate in Example 17 described later. It is shown.
　実施例１１で用いたサンプルデータを用いた。前記１９種類のアミノ酸のうち４個を変数として含む、実施例４に記載した多変量のロジスティック回帰式（多変量関数）を当てはめ、認知症発症群と認知症非発症群の判別能を評価した。ここで、多変量ロジスティック回帰式の当てはめとは、実施例４に記載した多変量ロジスティック回帰式のアミノ酸値に当該サンプルデータを代入することをいう。判別能の評価にはＲＯＣ＿ＡＵＣを用いた。 The sample data used in Example 11 was used. The multivariate logistic regression equation (multivariate function) described in Example 4, which includes 4 of the 19 types of amino acids as variables, was applied to evaluate the discriminating ability between the dementia onset group and the dementia non-onset group. . Here, the fitting of the multivariate logistic regression formula means substituting the sample data into the amino acid values of the multivariate logistic regression formula described in Example 4. ROC_AUC was used for evaluation of discrimination ability.
　これらのロジスティック回帰式（式に含まれる変数の個数は４個）のＲＯＣ＿ＡＵＣの一覧を、以下の［８．アミノ酸を含む４変数の式］に示した。これら７０８個のロジスティック回帰式に対応するＲＯＣ＿ＡＵＣ値は最も低いものでも０．６４以上と高いことから、これらのロジスティック回帰式は、実施例１１に記載した評価に有用である。なお、以下の［８．アミノ酸を含む４変数の式］には、各式に関して、式に含まれる変数と、実施例４におけるＲＯＣ＿ＡＵＣ値と、実施例１３におけるＲＯＣ＿ＡＵＣ値と、後述する実施例１８における偽陽性率と、後述する実施例２１におけるＲＯＣ＿ＡＵＣ値と、後述する実施例２４におけるＲＯＣ＿ＡＵＣ値と、が示されている。 　The list of ROC_AUC of these logistic regression formulas (the number of variables included in the formula is 4) is shown in [8. Four-variable formula including amino acids]. These logistic regression equations are useful for the evaluation described in Example 11 because the ROC_AUC values corresponding to these 708 logistic regression equations are as high as 0.64 or more, even at the lowest. Note that the following [8. Four-variable formula containing amino acids] includes, for each formula, the variables included in the formula, the ROC_AUC value in Example 4, the ROC_AUC value in Example 13, the false positive rate in Example 18 described later, and the The ROC_AUC value in Example 21 and the ROC_AUC value in Example 24, which will be described later, are shown.
　実施例１１で用いたサンプルデータを用いた。前記１９種類のアミノ酸のうち５個を変数として含む、実施例５に記載した多変量のロジスティック回帰式（多変量関数）を当てはめ、認知症発症群と認知症非発症群の判別能を評価した。ここで、多変量ロジスティック回帰式の当てはめとは、実施例５に記載した多変量ロジスティック回帰式のアミノ酸値に当該サンプルデータを代入することをいう。判別能の評価にはＲＯＣ＿ＡＵＣを用いた。 The sample data used in Example 11 was used. The multivariate logistic regression formula (multivariate function) described in Example 5, which includes 5 of the 19 types of amino acids as variables, was applied to evaluate the discriminating ability between the dementia onset group and the dementia non-onset group. . Here, the fitting of the multivariate logistic regression equation means substituting the sample data into the amino acid values of the multivariate logistic regression equation described in Example 5. ROC_AUC was used for evaluation of discrimination ability.
　これらのロジスティック回帰式（式に含まれる変数の個数は５個）のＲＯＣ＿ＡＵＣの一覧を、以下の［９．アミノ酸を含む５変数の式］に示した。これら１，００９個のロジスティック回帰式に対応するＲＯＣ＿ＡＵＣ値は最も低いものでも０．６５以上と高いことから、これらのロジスティック回帰式は、実施例１１に記載した評価に有用である。なお、以下の［９．アミノ酸を含む５変数の式］には、各式に関して、式に含まれる変数と、実施例５におけるＲＯＣ＿ＡＵＣ値と、実施例１４におけるＲＯＣ＿ＡＵＣ値と、後述する実施例１９における偽陽性率と、後述する実施例２２におけるＲＯＣ＿ＡＵＣ値と、後述する実施例２５におけるＲＯＣ＿ＡＵＣ値と、が示されている。 The list of ROC_AUC of these logistic regression formulas (the number of variables included in the formula is 5) is shown in [9. A five-variable formula including amino acids]. These logistic regression equations are useful for the evaluation described in Example 11 because the ROC_AUC values corresponding to these 1,009 logistic regression equations are as high as 0.65 or higher, even at the lowest. Note that the following [9. Five-variable formula containing amino acids] includes, for each formula, the variables included in the formula, the ROC_AUC value in Example 5, the ROC_AUC value in Example 14, the false positive rate in Example 19 described later, and the The ROC_AUC value in Example 22 and the ROC_AUC value in Example 25, which will be described later, are shown.
　実施例１１で用いたサンプルデータを用いた。前記１９種類のアミノ酸のうち６個を変数として含む、実施例６に記載した多変量のロジスティック回帰式（多変量関数）を当てはめ、認知症発症群と認知症非発症群の判別能を評価した。ここで、多変量ロジスティック回帰式の当てはめとは、実施例６に記載した多変量ロジスティック回帰式のアミノ酸値に当該サンプルデータを代入することをいう。判別能の評価にはＲＯＣ＿ＡＵＣを用いた。 The sample data used in Example 11 was used. The multivariate logistic regression equation (multivariate function) described in Example 6, which includes 6 of the 19 types of amino acids as variables, was applied to evaluate the ability to discriminate between the dementia onset group and the dementia non-onset group. . Here, the fitting of the multivariate logistic regression formula means substituting the sample data into the amino acid values of the multivariate logistic regression formula described in Example 6. ROC_AUC was used for evaluation of discrimination ability.
　これらのロジスティック回帰式（式に含まれる変数の個数は６個）のＲＯＣ＿ＡＵＣの一覧を、以下の［１０．アミノ酸を含む６変数の式］に示した。これら１，９６５個のロジスティック回帰式に対応するＲＯＣ＿ＡＵＣ値は最も低いものでも０．６４以上と高いことから、これらのロジスティック回帰式は、実施例１１に記載した評価に有用である。なお、以下の［１０．アミノ酸を含む６変数の式］には、各式に関して、式に含まれる変数と、実施例６におけるＲＯＣ＿ＡＵＣ値と、実施例１５におけるＲＯＣ＿ＡＵＣ値と、後述する実施例２０における偽陽性率と、後述する実施例２３におけるＲＯＣ＿ＡＵＣ値と、後述する実施例２６におけるＲＯＣ＿ＡＵＣ値と、が示されている。 The list of ROC_AUC of these logistic regression formulas (the number of variables included in the formula is 6) is shown in [10. 6-variable formula including amino acids]. These logistic regression equations are useful for the evaluation described in Example 11 because the ROC_AUC values corresponding to these 1,965 logistic regression equations are as high as 0.64 or higher, even at the lowest. In addition, the following [10. Six-variable formula containing amino acids] includes, for each formula, the variables included in the formula, the ROC_AUC value in Example 6, the ROC_AUC value in Example 15, the false positive rate in Example 20 described later, and the The ROC_AUC value in Example 23 and the ROC_AUC value in Example 26, which will be described later, are shown.
　５０歳以上の健康診断受診者の血液サンプル、およびサンプル取得後１年後の健康診断受診データを取得した。前述の測定方法（Ａ）を用いて、取得した血液サンプルから前記１９種のアミノ酸の血中濃度（ｎｍｏｌ／ｍｌ）を測定した。 We obtained blood samples from health checkup participants over the age of 50, and health checkup data one year after the sample was obtained. Blood concentrations (nmol/ml) of the above 19 amino acids were measured from the obtained blood samples using the measurement method (A) described above.
　上記健康診断受診者は、全受診者において血液サンプル取得から１年後に自立して健康診断受診が可能であったことから、血液サンプル取得から１年後に認知機能低下に伴う日常生活動作に支障が無い者、すなわち認知症非発症者とみなし、問診データによりがん、精神疾患、または腎疾患の既往もしくは現有が疑われるものは除外した。除外後の全５４４例を評価対象とした。 All of the above-mentioned health checkup participants were able to undergo the health checkup independently one year after the blood sample was obtained. Those who did not have dementia, that is, those who did not develop dementia were considered, and those suspected of having or having a history of cancer, mental illness, or renal disease based on interview data were excluded. A total of 544 cases after exclusion were included in the evaluation.
　測定した健康診断受診者のサンプルデータについて、前記１９種類のアミノ酸のうち２個を変数として含む、実施例２に記載した多変量のロジスティック回帰式（多変量関数）を当てはめ、認知症発症群と認知症非発症群を判別する際の偽陽性率を求めた。ここで、多変量ロジスティック回帰式の当てはめとは、実施例２に記載した多変量ロジスティック回帰式のアミノ酸値に当該サンプルデータを代入することをいう。また、ここで、偽陽性率とは、前述の健康診断受診者のサンプルデータ（認知症非発症者５４４例）中、実施例２に記載した多変量ロジスティック回帰式によって認知症発症群と誤って判別された割合をいい、以下の式で表される（以下同様）。
偽陽性率（％）＝１００×認知症発症群と判別された者の数÷（認知症非発症群と判別された者の数＋認知症発症群と判別された者の数） For the sample data of the measured health checkup subjects, the multivariate logistic regression equation (multivariate function) described in Example 2, which includes two of the 19 types of amino acids as variables, is applied, and the dementia onset group and The false-positive rate when discriminating the dementia non-onset group was obtained. Here, the fitting of the multivariate logistic regression formula means substituting the sample data into the amino acid values of the multivariate logistic regression formula described in Example 2. Further, here, the false positive rate is the sample data of the above-mentioned health checkup subjects (544 cases of non-dementia patients), by the multivariate logistic regression formula described in Example 2. Refers to the determined ratio, which is represented by the following formula (the same applies hereinafter).
False positive rate (%) = 100 × number of persons identified as dementia onset group ÷ (number of persons identified as non-dementia onset group + number of persons identified as dementia onset group)
　認知症発症群と認知症非発症群を判別するカットオフ値は、実施例１に記載したサンプルデータおよび実施例２に記載した多変量ロジスティック回帰式において特異度が９５％となる点として求めた。ここで、特異度とは、実施例１に記載したサンプルデータにおける認知症非発症者（６５例）中、実施例２に記載した多変量ロジスティック回帰式によって認知症非発症群と正しく判別された割合をいい、以下の式で表される（以下同様）。
特異度（％）＝１００×認知症非発症群と判別された者の数÷（認知症非発症群と判別された者の数＋認知症発症群と判別された者の数） The cutoff value for discriminating between the dementia onset group and the dementia non-onset group is the sample data described in Example 1 and the multivariate logistic regression equation described in Example 2. It was obtained as a point at which the specificity was 95%. . Here, the specificity is the dementia non-development group by the multivariate logistic regression formula described in Example 2 among the dementia non-developers (65 cases) in the sample data described in Example 1. It was correctly discriminated. Refers to the ratio and is represented by the following formula (same below).
Specificity (%) = 100 × number of persons identified as dementia non-onset group ÷ (number of persons identified as non-dementia onset group + number of persons identified as dementia onset group)
　これらのロジスティック回帰式（式に含まれる変数の個数は２個）の、前述の健康診断受診者を対象とした認知症非発症群と認知症発症群の判別における偽陽性率の一覧を、以下の［６．アミノ酸を含む２変数の式］に示した。これら１２１個のロジスティック回帰式に対応する偽陽性率は最も高いものでも１６％未満と低いことから、これら２変数のロジスティック回帰式は、認知機能健常もしくはＭＣＩであると推定される者の集団（例えば、健康診断受診者など）を対象とした「認知症を将来発症するリスクの評価（例えば、認知症を将来発症するリスクが高いか低いかの２群判別、など）」に有用である。 These logistic regression formulas (the number of variables included in the formula is 2), the list of false positive rates in discriminating between the dementia non-development group and the dementia development group for the above-mentioned health checkup subjects, of [6. A two-variable formula including amino acids]. Since the false-positive rate corresponding to these 121 logistic regression equations is as low as less than 16% at the highest, these two-variable logistic regression equations represent a population of people presumed to have cognitively healthy or MCI ( For example, it is useful for "evaluating the risk of developing dementia in the future (e.g., 2-group discrimination as to whether the risk of developing dementia in the future is high or low, etc.)".
　実施例１６で用いたサンプルデータを用いた。前記１９種類のアミノ酸のうち３個を変数として含む、実施例３に記載した多変量のロジスティック回帰式（多変量関数）を当てはめ、認知症発症群と認知症非発症群を判別する際の偽陽性率を求めた。ここで、偽陽性率とは、前述のサンプルデータ（認知症非発症者５４４例）中、実施例３に記載した多変量ロジスティック回帰式によって認知症発症群と誤って判別された割合をいう。 The sample data used in Example 16 was used. Applying the multivariate logistic regression equation (multivariate function) described in Example 3, including 3 of the 19 types of amino acids as variables, false when discriminating between the dementia onset group and the dementia non-onset group A positive rate was obtained. Here, the false positive rate refers to the ratio of the dementia onset group that was erroneously discriminated by the multivariate logistic regression equation described in Example 3 among the sample data (544 non-dementia patients) described above.
　認知症発症群と認知症非発症群を判別するカットオフ値は、実施例１に記載したサンプルデータおよび実施例３に記載した多変量ロジスティック回帰式において特異度が９５％となる点として求めた。ここで、特異度とは、実施例１に記載したサンプルデータにおける認知症非発症者（６５例）中、実施例３に記載した多変量ロジスティック回帰式によって認知症非発症群と正しく判別された割合をいう。 The cutoff value for discriminating between the dementia onset group and the dementia non-onset group is the sample data described in Example 1 and the multivariate logistic regression equation described in Example 3. It was obtained as a point at which the specificity was 95%. . Here, the specificity is the dementia non-development group by the multivariate logistic regression formula described in Example 3 among the dementia non-developers (65 cases) in the sample data described in Example 1. It was correctly discriminated. Percentage.
　これらのロジスティック回帰式（式に含まれる変数の個数は３個）の、実施例１６で用いたサンプルデータでの認知症非発症群と認知症発症群の判別における偽陽性率の一覧を、以下の［７．アミノ酸を含む３変数の式］に示した。これら５７３個のロジスティック回帰式に対応する偽陽性率は最も高いものでも２０％未満と低いことから、これら３変数のロジスティック回帰式は、実施例１６に記載した評価に有用である。 These logistic regression formulas (the number of variables included in the formula is 3), a list of false positive rates in discriminating between the dementia non-development group and the dementia development group in the sample data used in Example 16, of [7. Three-variable formula including amino acids]. These 3-variable logistic regression equations are useful for the evaluation described in Example 16 because the false positive rate corresponding to these 573 logistic regression equations is as low as less than 20% at the highest.
　実施例１６で用いたサンプルデータを用いた。前記１９種類のアミノ酸のうち４個を変数として含む、実施例４に記載した多変量のロジスティック回帰式（多変量関数）を当てはめ、認知症発症群と認知症非発症群を判別する際の偽陽性率を求めた。ここで、偽陽性率とは、前述のサンプルデータ（認知症非発症者５４４例）中、実施例４に記載した多変量ロジスティック回帰式によって認知症発症群と誤って判別された割合をいう。 The sample data used in Example 16 was used. Applying the multivariate logistic regression equation (multivariate function) described in Example 4, which includes 4 of the 19 types of amino acids as variables, false when discriminating between the dementia onset group and the dementia non-onset group A positive rate was obtained. Here, the false positive rate refers to the ratio of the dementia onset group erroneously discriminated by the multivariate logistic regression equation described in Example 4 among the sample data (544 non-dementia patients) described above.
　認知症発症群と認知症非発症群を判別するカットオフ値は、実施例１に記載したサンプルデータおよび実施例４に記載した多変量ロジスティック回帰式において特異度が９５％となる点として求めた。ここで、特異度とは、実施例１に記載したサンプルデータにおける認知症非発症者（６５例）中、実施例４に記載した多変量ロジスティック回帰式によって認知症非発症群と正しく判別された割合をいう。 The cutoff value for discriminating between the dementia onset group and the dementia non-onset group is the sample data described in Example 1 and the multivariate logistic regression equation described in Example 4. It was obtained as a point at which the specificity was 95%. . Here, the specificity is the non-dementia non-development group (65 cases) in the sample data described in Example 1, and the non-dementia non-development group by the multivariate logistic regression formula described in Example 4. Percentage.
　これらのロジスティック回帰式（式に含まれる変数の個数は４個）の、実施例１６で用いたサンプルデータでの認知症非発症群と認知症発症群の判別における偽陽性率の一覧を、以下の［８．アミノ酸を含む４変数の式］に示した。これら７０８個のロジスティック回帰式に対応する偽陽性率は最も高いものでも１２％未満と低いことから、これら４変数のロジスティック回帰式は、実施例１６に記載した評価に有用である。 These logistic regression formulas (the number of variables included in the formula is 4), a list of false positive rates in discriminating between the dementia non-development group and the dementia development group in the sample data used in Example 16, below. of [8. Four-variable formula including amino acids]. These 4-variable logistic regression equations are useful for the evaluation described in Example 16 because the false positive rate corresponding to these 708 logistic regression equations is as low as less than 12% at the highest.
　実施例１６で用いたサンプルデータを用いた。前記１９種類のアミノ酸のうち５個を変数として含む、実施例５に記載した多変量のロジスティック回帰式（多変量関数）を当てはめ、認知症発症群と認知症非発症群を判別する際の偽陽性率を求めた。ここで、偽陽性率とは、前述のサンプルデータ（認知症非発症者５４４例）中、実施例５に記載した多変量ロジスティック回帰式によって認知症発症群と誤って判別された割合をいう。 The sample data used in Example 16 was used. Applying the multivariate logistic regression equation (multivariate function) described in Example 5, including 5 of the 19 types of amino acids as variables, false when discriminating between the dementia onset group and the dementia non-onset group A positive rate was obtained. Here, the false positive rate refers to the ratio of the dementia onset group erroneously discriminated by the multivariate logistic regression equation described in Example 5 in the sample data (544 non-dementia patients).
　認知症発症群と認知症非発症群を判別するカットオフ値は、実施例１に記載したサンプルデータおよび実施例５に記載した多変量ロジスティック回帰式において特異度が９５％となる点として求めた。ここで、特異度とは、実施例１に記載したサンプルデータにおける認知症非発症者（６５例）中、実施例５に記載した多変量ロジスティック回帰式によって認知症非発症群と正しく判別された割合をいう。 The cutoff value for discriminating between the dementia onset group and the dementia non-onset group is the sample data described in Example 1 and the multivariate logistic regression equation described in Example 5. It was obtained as a point at which the specificity was 95%. . Here, the specificity is the dementia non-development group by the multivariate logistic regression formula described in Example 5 among the dementia non-developers (65 cases) in the sample data described in Example 1. It was correctly discriminated. Percentage.
　これらのロジスティック回帰式（式に含まれる変数の個数は５個）の、実施例１６で用いたサンプルデータでの認知症非発症群と認知症発症群の判別における偽陽性率の一覧を、以下の［９．アミノ酸を含む５変数の式］に示した。これら１，００９個のロジスティック回帰式に対応する偽陽性率は最も高いものでも１１％未満と低いことから、これら５変数のロジスティック回帰式は、実施例１６に記載した評価に有用である。 These logistic regression formulas (the number of variables included in the formula is 5), a list of false positive rates in discriminating between the dementia non-development group and the dementia development group in the sample data used in Example 16, below. of [9. A five-variable formula including amino acids]. These 5-variable logistic regression equations are useful for the evaluation described in Example 16 because the false positive rate corresponding to these 1,009 logistic regression equations is as low as less than 11% at the highest.
　実施例１６で用いたサンプルデータを用いた。前記１９種類のアミノ酸のうち６個を変数として含む、実施例６に記載した多変量のロジスティック回帰式（多変量関数）を当てはめ、認知症発症群と認知症非発症群を判別する際の偽陽性率を求めた。ここで、偽陽性率とは、前述のサンプルデータ（認知症非発症者５４４例）中、実施例６に記載した多変量ロジスティック回帰式によって認知症発症群と誤って判別された割合をいう。 The sample data used in Example 16 was used. Applying the multivariate logistic regression equation (multivariate function) described in Example 6, including 6 of the 19 types of amino acids as variables, false when discriminating between the dementia onset group and the dementia non-onset group A positive rate was obtained. Here, the false positive rate refers to the ratio of the dementia onset group erroneously discriminated by the multivariate logistic regression formula described in Example 6 among the sample data (544 non-dementia patients) described above.
　認知症発症群と認知症非発症群を判別するカットオフ値は、実施例１に記載したサンプルデータおよび実施例６に記載した多変量ロジスティック回帰式において特異度が９５％となる点として求めた。ここで、特異度とは、実施例１に記載したサンプルデータにおける認知症非発症者（６５例）中、実施例６に記載した多変量ロジスティック回帰式によって認知症非発症群と正しく判別された割合をいう。 The cutoff value for discriminating between the dementia onset group and the dementia non-onset group is the sample data described in Example 1 and the multivariate logistic regression equation described in Example 6. It was obtained as a point at which the specificity was 95%. . Here, the specificity is the dementia non-development group by the multivariate logistic regression formula described in Example 6 among the dementia non-developers (65 cases) in the sample data described in Example 1. It was correctly discriminated. Percentage.
　これらのロジスティック回帰式（式に含まれる変数の個数は６個）の、実施例１６で用いたサンプルデータでの認知症非発症群と認知症発症群の判別における偽陽性率の一覧を、以下の［１０．アミノ酸を含む６変数の式］に示した。これら１，９６５個のロジスティック回帰式に対応する偽陽性率は最も高いものでも１１％未満と低いことから、これら６変数のロジスティック回帰式は、実施例１６に記載した評価に有用である。 These logistic regression formulas (the number of variables included in the formula is 6), a list of false positive rates in discriminating between the dementia non-development group and the dementia development group in the sample data used in Example 16, of [10. 6-variable formula including amino acids]. These 6-variable logistic regression equations are useful for the evaluation described in Example 16 because the false positive rate corresponding to these 1,965 logistic regression equations is as low as less than 11% at the highest.
　５０歳以上のＭＣＩ者２１９名、５０歳以上の認知機能健常者２２０名に対して、年齢および性別を変数とする傾向スコアマッチングにより、ＭＣＩ者１２０名、認知機能健常者１２０名のデータを抽出し、式導出用データとした。 Data of 120 people with MCI and 120 people with normal cognitive function were extracted by propensity score matching using age and gender as variables for 219 people with MCI aged 50 and over and 220 people with normal cognitive function aged 50 and over. and used as data for formula derivation.
　式導出データに対し、Ｃｉｔ，Ｌｙｓ，Ｏｒｎ，Ｓｅｒ，Ｔｈｒ，Ｔｒｐの血中アミノ酸濃度（ｎｍｏｌ／ｍｌ）を変数とし、ＭＣＩ者と認知機能健常者を判別するロジスティック回帰式（６変量ロジスティック回帰式）を求めた。得られた６変量ロジスティック回帰式を前述の認知機能健常者２２０名に当てはめた際に、特異度が６０％となる点を第一カットオフ値、特異度が９０％となる点を第二カットオフ値とした。６変量ロジスティック回帰式の値が第一カットオフ値未満の場合を「ランクＡ」、第一カットオフ値以上かつ第二カットオフ値未満の場合を「ランクＢ」、第二カットオフ値以上の場合を「ランクＣ」とした。なお、この「ランクＢ」と「ランクＣ」は、アミノインデックス（登録商標） 生活習慣病リスクスクリーニング（ＡＩＬＳ（エーアイエルエス）（登録商標））中のＡＩＬＳ（認知機能低下）におけるランクＢ、ランクＣに相当する。 A logistic regression equation (6-variable logistic regression equation) that discriminates MCI subjects from those with normal cognitive function using the blood amino acid concentrations (nmol/ml) of Cit, Lys, Orn, Ser, Thr, and Trp as variables for formula-derived data ). When the obtained 6-variable logistic regression formula is applied to the aforementioned 220 healthy subjects with cognitive function, the first cut-off value is the point where the specificity is 60%, and the point where the specificity is 90% is the second cut. Off value. "Rank A" if the value of the 6-variable logistic regression equation is less than the first cutoff value, "Rank B" if the first cutoff value or more and less than the second cutoff value, the second cutoff value or more The case was designated as "rank C". In addition, this "rank B" and "rank C" are rank B and rank C in AILS (cognitive function decline) in AminoIndex (registered trademark) Lifestyle-related disease risk screening (AILS (registered trademark)) corresponds to
　ＭＣＩと診断された５０歳以上の高齢者の血液サンプルおよびサンプル取得後９カ月～１５カ月経過時の認知症専門医による認知症診断情報を取得した（計１５９例）。前述の測定方法（Ａ）を用いて、取得した血液サンプルから前記１９種のアミノ酸の血中濃度（ｎｍｏｌ／ｍｌ）を測定した。 We obtained blood samples from elderly people aged 50 and over who were diagnosed with MCI and dementia diagnosis information by dementia specialists 9 to 15 months after sample acquisition (total of 159 cases). Blood concentrations (nmol/ml) of the above 19 amino acids were measured from the obtained blood samples using the measurement method (A) described above.
　測定したアミノ酸の血中濃度データから、前述の方法によりアミノインデックス （登録商標） 生活習慣病リスクスクリーニング(ＡＩＬＳ（エーアイエルエス）（登録商標）)中のＡＩＬＳ（認知機能低下）ランクを算出し、ランクＢもしくはランクＣであった者（計１１０例）を対象とした。ここで、ＡＩＬＳ（認知機能低下）がランクＢもしくはランクＣであったことは、現在認知機能が低下している可能性が高いと評価されたことを意味する。取得した認知症診断情報に従って、この１１０例を、認知症発症群（ＡＤ発症２８例、ＤＬＢ発症２例、計３０例）と認知症非発症群（８０例）に分類した。 From the measured blood concentration data of amino acids, AILS (cognitive function decline) rank in Amino Index (registered trademark) Lifestyle-related disease risk screening (AILS (registered trademark)) was calculated by the method described above. Subjects who were ranked B or C (total of 110 cases) were included. Here, the fact that the AILS (cognitive function decline) was rank B or rank C means that the possibility of current cognitive function decline was evaluated to be high. According to the acquired dementia diagnosis information, these 110 cases were classified into a dementia onset group (AD onset 28 cases, DLB onset 2 cases, total 30 cases) and a dementia non-onset group (80 cases).
　測定したサンプルデータについて、前記１９種類のアミノ酸のうち４個を変数として含む、実施例４に記載した多変量のロジスティック回帰式（多変量関数）を当てはめ、認知症発症群と認知症非発症群の判別能を評価した。ここで、多変量ロジスティック回帰式の当てはめとは、実施例４に記載した多変量ロジスティック回帰式のアミノ酸値に前述のサンプルデータを代入することをいう。判別能の評価にはＲＯＣ＿ＡＵＣを用いた。 For the measured sample data, applying the multivariate logistic regression formula (multivariate function) described in Example 4, including 4 of the 19 types of amino acids as variables, dementia onset group and dementia non-onset group was evaluated. Here, the fitting of the multivariate logistic regression formula means substituting the aforementioned sample data for the amino acid values of the multivariate logistic regression formula described in Example 4. ROC_AUC was used for evaluation of discrimination ability.
　これらのロジスティック回帰式（式に含まれる変数の個数は４個）のＲＯＣ＿ＡＵＣの一覧を、以下の［８．アミノ酸を含む４変数の式］に示した。これら７０８個のロジスティック回帰式に対応するＲＯＣ＿ＡＵＣ値は最も低いものでも０．６０以上と高いことから、これらのロジスティック回帰式は、検査などの何らかの手段により認知機能が低下している可能性が高いと評価された者（例えばＡＩＬＳ（認知機能低下）でランクＢもしくはランクＣである者）を対象とした「認知症を将来発症するリスクの評価（例えば、認知症を将来発症するリスクが高いか低いかの２群判別、など）」に有用である。 　The list of ROC_AUC of these logistic regression formulas (the number of variables included in the formula is 4) is shown in [8. Four-variable formula including amino acids]. Since the lowest ROC_AUC value corresponding to these 708 logistic regression equations is as high as 0.60 or more, these logistic regression equations are highly likely to have cognitive decline due to some means such as testing. (e.g., AILS (cognitive decline) rank B or rank C) "Evaluation of the risk of developing dementia in the future (e.g., whether the risk of developing dementia in the future is high It is useful for 2-group discrimination of low or not, etc.).
　実施例２１で用いたサンプルデータを用いた。前記１９種類のアミノ酸のうち５個を変数として含む、実施例５に記載した多変量のロジスティック回帰式（多変量関数）を当てはめ、認知症発症群と認知症非発症群の判別能を評価した。ここで、多変量ロジスティック回帰式の当てはめとは、実施例５に記載した多変量ロジスティック回帰式のアミノ酸値に前述のサンプルデータを代入することをいう。判別能の評価にはＲＯＣ＿ＡＵＣを用いた。 The sample data used in Example 21 was used. The multivariate logistic regression formula (multivariate function) described in Example 5, which includes 5 of the 19 types of amino acids as variables, was applied to evaluate the discriminating ability between the dementia onset group and the dementia non-onset group. . Here, the fitting of the multivariate logistic regression equation means substituting the aforementioned sample data for the amino acid values of the multivariate logistic regression equation described in Example 5. ROC_AUC was used for evaluation of discrimination ability.
　これらのロジスティック回帰式（式に含まれる変数の個数は５個）のＲＯＣ＿ＡＵＣの一覧を、以下の［９．アミノ酸を含む５変数の式］に示した。これら１，００９個のロジスティック回帰式に対応するＲＯＣ＿ＡＵＣ値は最も低いものでも０．６２以上と高いことから、これらのロジスティック回帰式は、実施例２１に記載した評価に有用である。 The list of ROC_AUC of these logistic regression formulas (the number of variables included in the formula is 5) is shown in [9. A five-variable formula including amino acids]. These logistic regression equations are useful for the evaluation described in Example 21 because the ROC_AUC values corresponding to these 1,009 logistic regression equations are as high as 0.62 or higher, even at the lowest.
　実施例２１で用いたサンプルデータを用いた。前記１９種類のアミノ酸のうち６個を変数として含む、実施例６に記載した多変量のロジスティック回帰式（多変量関数）を当てはめ、認知症発症群と認知症非発症群の判別能を評価した。ここで、多変量ロジスティック回帰式の当てはめとは、実施例６に記載した多変量ロジスティック回帰式のアミノ酸値に前述のサンプルデータを代入することをいう。判別能の評価にはＲＯＣ＿ＡＵＣを用いた。 The sample data used in Example 21 was used. The multivariate logistic regression equation (multivariate function) described in Example 6, which includes 6 of the 19 types of amino acids as variables, was applied to evaluate the ability to discriminate between the dementia onset group and the dementia non-onset group. . Here, the fitting of the multivariate logistic regression formula means substituting the aforementioned sample data for the amino acid values of the multivariate logistic regression formula described in Example 6. ROC_AUC was used for evaluation of discrimination ability.
　これらのロジスティック回帰式（式に含まれる変数の個数は６個）のＲＯＣ＿ＡＵＣの一覧を、以下の［１０．アミノ酸を含む６変数の式］に示した。これら１，９６５個のロジスティック回帰式に対応するＲＯＣ＿ＡＵＣ値は最も低いものでも０．６２以上と高いことから、これらのロジスティック回帰式は、実施例２１に記載した評価に有用である。 The list of ROC_AUC of these logistic regression formulas (the number of variables included in the formula is 6) is shown in [10. 6-variable formula including amino acids]. Since the ROC_AUC values corresponding to these 1,965 logistic regression equations are as high as 0.62 or higher, these logistic regression equations are useful for the evaluation described in Example 21.
　ＭＣＩと診断された５０歳以上の高齢者の血液サンプルおよびサンプル取得後９カ月～１５カ月経過時の認知症専門医による認知症診断情報を取得した（計１５９例）。前述の測定方法（Ａ）を用いて、取得した血液サンプルから前記１９種のアミノ酸の血中濃度（ｎｍｏｌ／ｍｌ）を測定した。 We obtained blood samples from elderly people aged 50 and over who were diagnosed with MCI and dementia diagnosis information by dementia specialists 9 to 15 months after sample acquisition (total of 159 cases). Blood concentrations (nmol/ml) of the above 19 amino acids were measured from the obtained blood samples using the measurement method (A) described above.
　測定したアミノ酸の血中濃度データから、実施例２１に記載の方法によりアミノインデックス（登録商標） 生活習慣病リスクスクリーニング(ＡＩＬＳ（エーアイエルエス）（登録商標）)中のＡＩＬＳ（認知機能低下）ランクを算出し、ランクＣであった者（計５２例）を対象とした。ここで、ＡＩＬＳ（認知機能低下）がランクＣであったことは、現在認知機能が低下している可能性が高いと評価されたことを意味する。取得した認知症診断情報に従って、この５２例を、認知症発症群（ＡＤ発症１２例、ＤＬＢ発症１例、計１３例）と認知症非発症群（３９例）に分類した。 From the measured blood concentration data of amino acids, AILS (cognitive function decline) rank in AminoIndex (registered trademark) Lifestyle-related disease risk screening (AILS (registered trademark)) by the method described in Example 21. Those who were ranked C (total of 52 cases) were targeted. Here, the fact that the AILS (cognitive function decline) was rank C means that it was evaluated that there is a high possibility that the cognitive function is currently declining. According to the acquired dementia diagnosis information, these 52 cases were classified into a dementia onset group (AD onset: 12 cases, DLB onset: 1 case, total 13 cases) and a dementia non-onset group (39 cases).
　測定したサンプルデータについて、前記１９種類のアミノ酸のうち４個を変数として含む、実施例４に記載した多変量のロジスティック回帰式（多変量関数）を当てはめ、認知症発症群と認知症非発症群の判別能を評価した。ここで、多変量ロジスティック回帰式の当てはめとは、実施例４に記載した多変量ロジスティック回帰式のアミノ酸値に前述のサンプルデータを代入することをいう。判別能の評価にはＲＯＣ＿ＡＵＣを用いた。 For the measured sample data, applying the multivariate logistic regression formula (multivariate function) described in Example 4, including 4 of the 19 types of amino acids as variables, dementia onset group and dementia non-onset group was evaluated. Here, the fitting of the multivariate logistic regression formula means substituting the aforementioned sample data for the amino acid values of the multivariate logistic regression formula described in Example 4. ROC_AUC was used for evaluation of discrimination ability.
　これらのロジスティック回帰式（式に含まれる変数の個数は４個）のＲＯＣ＿ＡＵＣの一覧を、以下の［８．アミノ酸を含む４変数の式］に示した。これら７０８個のロジスティック回帰式に対応するＲＯＣ＿ＡＵＣ値は最も低いものでも０．５３以上と高いことから、これらのロジスティック回帰式は、検査などの何らかの手段により認知機能が低下している可能性が高いと評価された者（例えばＡＩＬＳ（認知機能低下）でランクＣである者）を対象とした「認知症を将来発症するリスクの評価（例えば、認知症を将来発症するリスクが高いか低いかの２群判別、など）」に有用である。 　The list of ROC_AUC of these logistic regression formulas (the number of variables included in the formula is 4) is shown in [8. Four-variable formula including amino acids]. Since the lowest ROC_AUC value corresponding to these 708 logistic regression equations is as high as 0.53 or more, these logistic regression equations are highly likely to have cognitive decline due to some means such as testing. "Evaluation of the risk of developing dementia in the future (e.g., whether the risk of developing dementia in the future is high or low 2 group discrimination, etc.)”.
　実施例２４で用いたサンプルデータを用いた。前記１９種類のアミノ酸のうち５個を変数として含む、実施例５に記載した多変量のロジスティック回帰式（多変量関数）を当てはめ、認知症発症群と認知症非発症群の判別能を評価した。ここで、多変量ロジスティック回帰式の当てはめとは、実施例５に記載した多変量ロジスティック回帰式のアミノ酸値に前述のサンプルデータを代入することをいう。判別能の評価にはＲＯＣ＿ＡＵＣを用いた。 The sample data used in Example 24 was used. The multivariate logistic regression formula (multivariate function) described in Example 5, which includes 5 of the 19 types of amino acids as variables, was applied to evaluate the discriminating ability between the dementia onset group and the dementia non-onset group. . Here, the fitting of the multivariate logistic regression equation means substituting the aforementioned sample data for the amino acid values of the multivariate logistic regression equation described in Example 5. ROC_AUC was used for evaluation of discrimination ability.
　これらのロジスティック回帰式（式に含まれる変数の個数は５個）のＲＯＣ＿ＡＵＣの一覧を、以下の［９．アミノ酸を含む５変数の式］に示した。これら１，００９個のロジスティック回帰式に対応するＲＯＣ＿ＡＵＣ値は最も低いものでも０．５５以上と高いことから、これらのロジスティック回帰式は、実施例２４に記載した評価に有用である。 The list of ROC_AUC of these logistic regression formulas (the number of variables included in the formula is 5) is shown in [9. A five-variable formula including amino acids]. These logistic regression equations are useful for the evaluation described in Example 24, since the lowest ROC_AUC values corresponding to these 1,009 logistic regression equations are as high as 0.55 or more.
　実施例２４で用いたサンプルデータを用いた。前記１９種類のアミノ酸のうち６個を変数として含む、実施例６に記載した多変量のロジスティック回帰式（多変量関数）を当てはめ、認知症発症群と認知症非発症群の判別能を評価した。ここで、多変量ロジスティック回帰式の当てはめとは、実施例６に記載した多変量ロジスティック回帰式のアミノ酸値に前述のサンプルデータを代入することをいう。判別能の評価にはＲＯＣ＿ＡＵＣを用いた。 The sample data used in Example 24 was used. The multivariate logistic regression equation (multivariate function) described in Example 6, which includes 6 of the 19 types of amino acids as variables, was applied to evaluate the ability to discriminate between the dementia onset group and the dementia non-onset group. . Here, the fitting of the multivariate logistic regression formula means substituting the aforementioned sample data for the amino acid values of the multivariate logistic regression formula described in Example 6. ROC_AUC was used for evaluation of discrimination ability.
　これらのロジスティック回帰式（式に含まれる変数の個数は６個）のＲＯＣ＿ＡＵＣの一覧を、以下の［１０．アミノ酸を含む６変数の式］に示した。これら１，９６５個のロジスティック回帰式に対応するＲＯＣ＿ＡＵＣ値は最も低いものでも０．５７以上と高いことから、これらのロジスティック回帰式は、実施例２４に記載した評価に有用である。 The list of ROC_AUC of these logistic regression formulas (the number of variables included in the formula is 6) is shown in [10. 6-variable formula including amino acids]. Since the ROC_AUC values corresponding to these 1,965 logistic regression equations are as high as 0.57 or higher, these logistic regression equations are useful for the evaluation described in Example 24.
　ＭＣＩと診断された５０歳以上の高齢者１１４例および認知機能健常と診断された５０歳以上の高齢者１例の血液サンプル、およびサンプル取得後約９カ月～２７カ月経過時の認知症専門医による認知症診断情報を取得した（計１１５例）。取得した認知症診断情報に従って、この１１５例を、認知症発症群（ＡＤ発症４９例、ＤＬＢ発症５例、計５４例）と認知症非発症群（６１例）に分類した。ここで、認知症非発症とは、血液サンプル取得後少なくとも約２１カ月より長期の診断時点でＭＣＩもしくは認知機能健常のいずれかの状態であったことをいう。また、前述の測定方法（Ａ）を用いて、取得した血液サンプルから前記１９種のアミノ酸の血中濃度（ｎｍｏｌ／ｍｌ）を測定した。 Blood samples from 114 individuals aged 50 and older diagnosed with MCI and 1 patient aged 50 and older diagnosed with normal cognitive function, and by a dementia specialist approximately 9 months to 27 months after sample acquisition Dementia diagnosis information was obtained (total of 115 cases). According to the acquired dementia diagnosis information, these 115 cases were classified into a dementia onset group (AD onset 49 cases, DLB onset 5 cases, total 54 cases) and a dementia non-onset group (61 cases). Here, dementia-free refers to either MCI or cognitively healthy at the time of diagnosis at least about 21 months after blood sample acquisition. In addition, blood concentrations (nmol/ml) of the 19 amino acids were measured from the obtained blood samples using the measurement method (A) described above.
　測定したサンプルデータについて、前記１９種類のアミノ酸および３種類の分岐鎖アミノ酸（Ｖａｌ、Ｌｅｕ、Ｉｌｅ）の血中濃度の総和（以下、「ＢＣＡＡ＿ｓｕｍ」と表記する。）で構成される２０変数のうち１個とＡＰＯＥε４アリルの保有の有無に関する二値変数（ダミー変数）とを含む多変量のロジスティック回帰式（多変量関数）を作成した。なお、ダミー変数の値について、ＡＰＯＥε４アリル保有無しの場合を０とし、ＡＰＯＥε４アリル保有ありの場合を１とした。そして、当該作成した多変量のロジスティック回帰式による認知症発症群と認知症非発症群の判別能を、前記１９種類のアミノ酸およびＢＣＡＡ＿ｓｕｍで構成される２０変数のうち１個からなる単変量ロジスティック回帰による認知症発症群と認知症非発症群の判別能と比較して評価した。ここで、判別能の評価にはＲＯＣ＿ＡＵＣを用いた。 Of the 20 variables composed of the sum of the blood concentrations of the 19 amino acids and the 3 branched-chain amino acids (Val, Leu, Ile) (hereinafter referred to as "BCAA_sum") for the measured sample data, A multivariate logistic regression equation (multivariate function) was created including one and a binary variable (dummy variable) regarding the presence or absence of the APOE ε4 allele. The value of the dummy variable was set to 0 when the APOE ε4 allele was not possessed and 1 when the APOE ε4 allele was possessed. Then, the ability to discriminate between the dementia onset group and the dementia non-onset group by the created multivariate logistic regression formula is a univariate logistic regression consisting of one out of 20 variables composed of the 19 types of amino acids and BCAA_sum. It was evaluated by comparing the ability to discriminate between the dementia onset group and the dementia non-onset group. Here, ROC_AUC was used for evaluation of discrimination ability.
　これらのロジスティック回帰式（式に含まれる変数の個数は１個または２個）のＲＯＣ＿ＡＵＣの一覧を、以下の表８に示す。なお、表８において、ΔＲＯＣ＿ＡＵＣは、２変量回帰式のＲＯＣ＿ＡＵＣから単変量回帰式のＲＯＣ＿ＡＵＣを引いた値である。ＡＰＯＥε４アリル保有情報の追加により、ＲＯＣ＿ＡＵＣは０．０７１～０．１５３上昇するため、前記２０変数から選ばれる任意の１個とＡＰＯＥε４アリル保有情報とを組み合わせることは、ＭＣＩである者と認知機能健常者を含む集団を対象とした「認知症を将来発症するリスクの評価（例えば、認知症を将来発症するリスクが高いか低いかの２群判別、など）」に有用である。特に、ＢＣＡＡ＿ｓｕｍ、Ｖａｌ、Ｌｅｕ、Ｉｌｅ、Ｔｒｐ、またはＧｌｙとＡＰＯＥε４アリル保有情報との組み合わせの２変量ロジスティック回帰式はそれぞれＲＯＣ＿ＡＵＣが０．７００以上と高いため、前記評価に有用であると考えられる。 A list of ROC_AUC of these logistic regression formulas (the number of variables included in the formula is 1 or 2) is shown in Table 8 below. In Table 8, ΔROC_AUC is a value obtained by subtracting the ROC_AUC of the univariate regression from the ROC_AUC of the bivariate regression. The addition of APOE ε4 allele possession information increases ROC_AUC by 0.071 to 0.153. It is useful for "evaluation of the risk of developing dementia in the future (for example, 2-group discrimination as to whether the risk of developing dementia in the future is high or low, etc.)" for a group including people. In particular, the bivariate logistic regression equations of BCAA_sum, Val, Leu, Ile, Trp, or the combination of Gly and APOE ε4 allele-bearing information each have a high ROC_AUC of 0.700 or more, and thus are considered useful for the above evaluation.
Figure JPOXMLDOC01-appb-T000008
Figure JPOXMLDOC01-appb-T000008
　実施例２７で用いたサンプルデータを用いた。前記１１５例のデータをＡＰＯＥ遺伝子情報に基づき、ＡＰＯＥε４アリル非保有群７５例（ＡＤ発症２６例、ＤＬＢ発症１例、認知症非発症４８例）とＡＰＯＥε４アリル保有群４０例（ＡＤ発症２３例、ＤＬＢ発症４例、認知症非発症１３例）に層別した。層別した各群において、前記２０変数のうち１個からなる単変量ロジスティック回帰式を作成し、認知症発症群と認知症非発症群の判別能を評価した。判別能の評価にはＲＯＣ＿ＡＵＣを用いた。 The sample data used in Example 27 was used. Based on the APOE genetic information of the 115 cases, 75 APOE ε4 allele non-bearing groups (AD onset 26 cases, DLB onset 1 case, dementia non-onset 48 cases) and APOE ε4 allele carrying group 40 cases (AD onset 23 cases, 4 cases with DLB and 13 cases without dementia). In each stratified group, a univariate logistic regression equation consisting of one of the 20 variables was created, and the ability to discriminate between the dementia onset group and the dementia non-onset group was evaluated. ROC_AUC was used for evaluation of discrimination ability.
　これらのロジスティック回帰式（式に含まれる変数の個数は１個）のＲＯＣ＿ＡＵＣの一覧を、以下の表９に示す。Ｃｉｔ以外の１９変数において、ＡＰＯＥε４アリル保有群とＡＰＯＥε４アリル非保有群でＲＯＣ＿ＡＵＣは異なるため、ＡＰＯＥε４アリル保有情報で層別することは実施例２７に記載の評価に有用である。特に、ＡＰＯＥε４アリル非保有群におけるＢＣＡＡ＿ｓｕｍ、Ｌｅｕ、およびＶａｌのＲＯＣ＿ＡＵＣはそれぞれ０．７００以上と高いため、評価対象をＡＰＯＥε４アリル非保有者に限定した場合、これらの変数を用いることは前記評価に有用であると考えられる。 A list of ROC_AUC of these logistic regression formulas (the number of variables included in the formula is one) is shown in Table 9 below. In 19 variables other than Cit, ROC_AUC differs between the APOE ε4 allele-bearing group and the APOE ε4 allele-non-bearing group. In particular, the ROC_AUC of BCAA_sum, Leu, and Val in the APOE ε4 allele non-carrier group is as high as 0.700 or higher, so when the evaluation target is limited to APOE ε4 allele non-carriers, using these variables is useful for the above evaluation. It is considered to be
Figure JPOXMLDOC01-appb-T000009
Figure JPOXMLDOC01-appb-T000009
　以上のように、本発明は、産業上の多くの分野、特に医薬品や食品、医療などの分野で広く実施することができ、極めて有用である。 As described above, the present invention can be widely implemented in many industrial fields, especially in fields such as pharmaceuticals, foods, and medical care, and is extremely useful.
　１００　評価装置
　　　　　１０２　制御部
　　　　　　　　　１０２ａ　受信部
　　　　　　　　　１０２ｂ　指定部
　　　　　　　　　１０２ｃ　式作成部
　　　　　　　　　１０２ｄ　評価部
　　　　　　　　　　　　　　１０２ｄ１　算出部
　　　　　　　　　　　　　　１０２ｄ２　変換部
　　　　　　　　　　　　　　１０２ｄ３　生成部
　　　　　　　　　　　　　　１０２ｄ４　分類部
　　　　　　　　　１０２ｅ　結果出力部
　　　　　　　　　１０２ｆ　送信部
　　　　　１０４　通信インターフェース部
　　　　　１０６　記憶部
　　　　　　　　　１０６ａ　測定データファイル
　　　　　　　　　１０６ｂ　指標状態情報ファイル
　　　　　　　　　１０６ｃ　指定指標状態情報ファイル
　　　　　　　　　１０６ｄ　式関連情報データベース
　　　　　　　　　　　　　　１０６ｄ１　式ファイル
　　　　　　　　　１０６ｅ　評価結果ファイル
　　　　　１０８　入出力インターフェース部
　　　　　１１２　入力装置
　　　　　１１４　出力装置
　２００　クライアント装置（端末装置（情報通信端末装置））
　３００　ネットワーク
　４００　データベース装置 100 evaluation device 102 control unit 102a reception unit 102b specification unit 102c formula creation unit 102d evaluation unit 102d1 calculation unit 102d2 conversion unit 102d3 generation unit 102d4 classification unit 102e result output unit 102f transmission unit 104 communication interface unit 106 storage unit 106a measurement data file 106b Index state information file 106c Designated index state information file 106d Formula related information database 106d1 Formula file 106e Evaluation result file 108 Input/output interface unit 112 Input device 114 Output device 200 Client device (terminal device (information communication terminal device))
300 network 400 database device
［１．アミノ酸を含む２変数の式］
Gln, Ile, 0.732; Asn, Leu, 0.724; Gln, Leu, 0.723; Tyr, Ile, 0.719; Asn, Ile, 0.717; Cit, Ile, 0.717; Ile, Phe, 0.716; Leu, Phe, 0.716; His, Ile, 0.713; Lys, Ile, 0.711; Tyr, Val, 0.71; Arg, Ile, 0.708; Met, Ile, 0.707; Pro, Ile, 0.707; Ile, Leu, 0.707; Gly, Ile, 0.706; Ala, Ile, 0.705; Ala, Leu, 0.705; Cit, Leu, 0.705; Lys, Leu, 0.705; Leu, Trp, 0.705; Thr, Ile, 0.704; Val, Leu, 0.704; Val, Lys, 0.703; Val, Ile, 0.703; Orn, Ile, 0.703; Ile, Trp, 0.703; Thr, Leu, 0.703; Tyr, Leu, 0.703; Met, Leu, 0.703; Orn, Leu, 0.702; Gly, Leu, 0.702; Gln, His, 0.701; Ser, Ile, 0.7; Ser, Leu, 0.7; His, Leu, 0.698; Gln, Val, 0.697; Arg, Leu, 0.697; Pro, Leu, 0.697; Gln, Lys, 0.697; His, Val, 0.697; Asn, Val, 0.693; Cit, Val, 0.69; Val, Phe, 0.689; Arg, Val, 0.688; Gln, Pro, 0.688; Val, Orn, 0.687; Pro, Val, 0.686; Val, Met, 0.686; Gln, Met, 0.685; Thr, Val, 0.682; Val, Trp, 0.681; Gly, Val, 0.68; Ala, Val, 0.68; Ser, Val, 0.678; Gln, Tyr, 0.676; Asn, Tyr, 0.668; Asn, Lys, 0.667; Arg, Tyr, 0.661; Arg, Lys, 0.66; His, Tyr, 0.657; His, Phe, 0.653; His, Met, 0.653; His, Thr, 0.652; His, Lys, 0.652; Ser, His, 0.651; Gly, His, 0.65; Asn, His, 0.647; His, Cit, 0.647; His, Orn, 0.646; His, Ala, 0.644; His, Pro, 0.643; Gln, Ala, 0.64; His, Arg, 0.64; Pro, Lys, 0.639; Cit, Tyr, 0.637; His, Trp, 0.634; Pro, Tyr, 0.634; Tyr, Lys, 0.634; Cit, Pro, 0.63; Gln, Arg, 0.63; Gly, Tyr, 0.63; Gln, Phe, 0.629; Gly, Pro, 0.628; Gly, Gln, 0.627; Gln, Thr, 0.627; Asn, Gln, 0.627; Ala, Pro, 0.626; Gln, Cit, 0.625; Tyr, Met, 0.625; Tyr, Phe, 0.625; Ser, Tyr, 0.624; Asn, Ala, 0.623; Ala, Tyr, 0.623; Thr, Tyr, 0.623; Ser, Gln, 0.622; Asn, Pro, 0.622; Ser, Pro, 0.622; Gln, Trp, 0.621; Thr, Pro, 0.621; Tyr, Orn, 0.621; Lys, Trp, 0.621; Tyr, Trp, 0.618; Arg, Pro, 0.617; Pro, Trp, 0.615; Pro, Phe, 0.613; Asn, Trp, 0.613; Pro, Orn, 0.613; Cit, Lys, 0.612; Gly, Lys, 0.611; Ala, Trp, 0.611; Thr, Lys, 0.61; Ser, Lys, 0.608; Gly, Ala, 0.607; Ala, Cit, 0.607; Gln, Orn, 0.606; Pro, Met, 0.605; Asn, Met, 0.604; Ala, Arg, 0.603; Ala, Lys, 0.603; Met, Lys, 0.601 [1. Bivariate formula containing amino acids]
Gln, Ile, 0.732; Asn, Leu, 0.724; Gln, Leu, 0.723; Tyr, Ile, 0.719; Ile, 0.713; Lys, Ile, 0.711; Tyr, Val, 0.71; Arg, Ile, 0.708; Met, Ile, 0.707; Ala, Leu, 0.705; Cit, Leu, 0.705; Lys, Leu, 0.705; Leu, Trp, 0.705; Thr, Ile, 0.704; Orn, Ile, 0.703; Ile, Trp, 0.703; Thr, Leu, 0.703; Tyr, Leu, 0.703; Met, Leu, 0.703; Ile, 0.7; Ser, Leu, 0.7; His, Leu, 0.698; Gln, Val, 0.697; Arg, Leu, 0.697; Val, Phe, 0.689; Arg, Val, 0.688; Gln, Pro, 0.688; Val, Orn, 0.687; Pro, Val, 0.686; Thr, Val, 0.682; Val, Trp, 0.681; Gly, Val, 0.68; Ala, Val, 0.68; Ser, Val, 0.678; Tyr, 0.661; Arg, His, Phe, 0.653; His, Met, 0.653; His, Thr, 0.652; His, Lys, 0.652; Ser, His, 0.651; His, Cit, 0.647; His, Orn, 0.646; His, Ala, 0.644; His, Pro, 0.643; Gln, Ala, 0.64; His, Trp, 0.634; Pro, Tyr, 0.634; Tyr, Lys, 0.634; Cit, Pro, 0.63; Gln, 0.627; Gln, Thr, 0.627; Asn, Gln, 0.627; Ala, Pro, 0.626; Ala, Tyr, 0.623; Thr, Tyr, 0.623; Ser, Gln, 0.622; Asn, Pro, 0.622; Ser, Pro, 0.622; Gln, Trp, 0.621; Lys, Trp, 0.621; Tyr, Trp, 0.618; Arg, Pro, 0.617; Pro, Trp, 0.615; Ala, Trp, 0.611; Thr, Lys, 0.61; Ser, Lys, 0.608; Gly, Ala, 0.607; Ala, Cit, 0.607; 0.604; Ala, Arg, Ala, Lys, 0.603; Met, Lys, 0.601
［２．アミノ酸を含む３変数の式］
Gln, His, Ile, 0.752; Gln, Lys, Ile, 0.745; Asn, Lys, Ile, 0.744; Gln, Leu, Phe, 0.741; Cit, Tyr, Ile, 0.741; Gln, Cit, Ile, 0.74; Gln, Tyr, Leu, 0.74; Gln, Lys, Leu, 0.74; Asn, Gln, Ile, 0.739; Gln, Ile, Phe, 0.739; Gln, Tyr, Ile, 0.738; Asn, Gln, Leu, 0.737; Asn, His, Ile, 0.737; Gln, Orn, Leu, 0.736; Gln, Ile, Leu, 0.736; Gln, His, Tyr, 0.735; Arg, Tyr, Lys, 0.735; Arg, Lys, Ile, 0.735; Tyr, Met, Ile, 0.735; Asn, Lys, Leu, 0.733; Asn, Tyr, Leu, 0.733; Gln, Pro, Ile, 0.733; Asn, Val, Lys, 0.732; Tyr, Ile, Phe, 0.732; Gln, Val, Ile, 0.731; Gln, Ile, Trp, 0.731; Gln, Arg, Ile, 0.731; His, Ile, Phe, 0.73; Tyr, Leu, Phe, 0.73; Gly, Gln, Ile, 0.73; Asn, Tyr, Ile, 0.73; Gln, Orn, Ile, 0.73; Asn, Ile, Leu, 0.729; Gln, Ala, Leu, 0.729; Asn, Gly, Leu, 0.728; Asn, Cit, Ile, 0.728; Gln, Ala, Ile, 0.728; Gly, Gln, Leu, 0.727; Gln, Val, Lys, 0.727; Ser, Gln, Ile, 0.726; Ser, Gln, Leu, 0.726; Asn, Leu, Phe, 0.726; Gln, Thr, Ile, 0.726; Asn, Tyr, Val, 0.726; Arg, Tyr, Ile, 0.726; Asn, His, Val, 0.725; Gln, Met, Ile, 0.725; His, Tyr, Ile, 0.724; Gln, His, Lys, 0.724; Gln, Leu, Trp, 0.724; Ile, Leu, Phe, 0.724; Gln, His, Pro, 0.723; Gln, Pro, Leu, 0.723; Gln, Tyr, Val, 0.723; Gln, Thr, Leu, 0.723; Cit, Ile, Phe, 0.723; Gln, Arg, Leu, 0.722; Tyr, Met, Leu, 0.722; Asn, Thr, Ile, 0.721; Asn, Ile, Trp, 0.721; Gln, His, Leu, 0.721; Cit, Lys, Ile, 0.721; Tyr, Ile, Trp, 0.721; Val, Ile, Phe, 0.721; Met, Lys, Ile, 0.721; Asn, Ala, Ile, 0.721; Asn, Orn, Leu, 0.721; Asn, Ile, Phe, 0.721; Asn, Met, Leu, 0.72; Gln, Cit, Leu, 0.72; Ala, Tyr, Ile, 0.72; Arg, Tyr, Leu, 0.72; Tyr, Orn, Ile, 0.72; Ser, Asn, Leu, 0.719; Asn, Leu, Trp, 0.719; Gly, Tyr, Ile, 0.719; Gln, Met, Leu, 0.719; Thr, Tyr, Ile, 0.719; Cit, Arg, Ile, 0.719; Cit, Tyr, Val, 0.719; Cit, Met, Ile, 0.719; Pro, Tyr, Ile, 0.719; Asn, Thr, Leu, 0.718; Ala, Cit, Ile, 0.718; Cit, Pro, Ile, 0.718; Arg, Val, Lys, 0.718; Lys, Ile, Phe, 0.718; Asn, His, Leu, 0.717; Asn, Pro, Leu, 0.717; Asn, Val, Leu, 0.717; Arg, Ile, Leu, 0.717; Asn, Gly, Ile, 0.717; Asn, Orn, Ile, 0.717; Gln, His, Val, 0.717; Gln, Val, Leu, 0.717; His, Arg, Ile, 0.717; His, Met, Ile, 0.717; Tyr, Val, Ile, 0.717; Ser, Asn, Ile, 0.716; Asn, Val, Ile, 0.716; Ala, Ile, Phe, 0.716; Tyr, Val, Met, 0.716; Gly, Cit, Ile, 0.716; His, Tyr, Val, 0.716; Thr, Cit, Ile, 0.716; Lys, Leu, Phe, 0.716; Asn, Ala, Leu, 0.715; Asn, Cit, Leu, 0.715; Asn, Arg, Ile, 0.715; Asn, Arg, Leu, 0.715; His, Leu, Phe, 0.715; Thr, Ile, Phe, 0.715; Thr, Leu, Phe, 0.715; Cit, Orn, Ile, 0.715; Cit, Ile, Trp, 0.715; Tyr, Lys, Ile, 0.715; Gly, His, Ile, 0.714; Gly, Cit, Leu, 0.714; Gly, Ile, Phe, 0.714; Ala, Met, Ile, 0.714; Cit, Val, Ile, 0.714; Arg, Val, Ile, 0.714; Arg, Lys, Leu, 0.714; Pro, Ile, Phe, 0.714; Val, Leu, Phe, 0.714; Orn, Ile, Phe, 0.714; Asn, Met, Ile, 0.714; Gly, Leu, Phe, 0.714; Ala, Arg, Ile, 0.714; Cit, Tyr, Leu, 0.714; Cit, Val, Leu, 0.714; Arg, Leu, Phe, 0.714; Lys, Ile, Leu, 0.714; Asn, Pro, Ile, 0.713; Gly, Tyr, Val, 0.713; His, Cit, Ile, 0.713; His, Pro, Ile, 0.713; His, Lys, Ile, 0.713; Cit, Ile, Leu, 0.713; Arg, Ile, Phe, 0.713; Val, Lys, Ile, 0.713; Ser, Tyr, Ile, 0.712; His, Ala, Ile, 0.712; His, Orn, Ile, 0.712; His, Ile, Leu, 0.712; Ile, Leu, Trp, 0.712; Ser, His, Ile, 0.712; His, Ile, Trp, 0.712; Ala, Met, Leu, 0.712; Ala, Leu, Trp, 0.712; Arg, Tyr, Val, 0.712; Tyr, Ile, Leu, 0.712; Met, Ile, Phe, 0.712; Ser, Cit, Ile, 0.711; Gly, Tyr, Leu, 0.711; Gln, His, Ala, 0.711; Pro, Tyr, Val, 0.711; Tyr, Val, Phe, 0.711; Val, Leu, Trp, 0.711; Ser, Leu, Phe, 0.71; Gly, Lys, Ile, 0.71; Gln, His, Orn, 0.71; Pro, Leu, Phe, 0.71; Lys, Ile, Trp, 0.71; Lys, Leu, Trp, 0.71; Leu, Phe, Trp, 0.71; Thr, Lys, Ile, 0.71; Ala, Tyr, Val, 0.71; Ala, Ile, Leu, 0.71; Pro, Met, Ile, 0.71; Met, Lys, Leu, 0.71; Gln, His, Met, 0.709; Ala, Leu, Phe, 0.709; Pro, Ile, Leu, 0.709; Tyr, Lys, Leu, 0.709; Tyr, Leu, Trp, 0.709; Met, Ile, Leu, 0.709; Met, Leu, Phe, 0.709; Ser, Ile, Phe, 0.709; Gly, Val, Leu, 0.709; Gly, Lys, Leu, 0.709; His, Thr, Ile, 0.709; His, Val, Ile, 0.709; Ala, Tyr, Leu, 0.709; Ala, Orn, Ile, 0.709; Arg, Pro, Ile, 0.709; Arg, Orn, Ile, 0.709; Tyr, Val, Trp, 0.709; Val, Lys, Leu, 0.709; Val, Lys, Phe, 0.709; Ser, Leu, Trp, 0.708; Gly, Arg, Ile, 0.708; Gly, Met, Ile, 0.708; Gly, Ile, Leu, 0.708; His, Cit, Val, 0.708; His, Val, Lys, 0.708; His, Val, Phe, 0.708; His, Leu, Trp, 0.708; Ala, Lys, Ile, 0.708; Arg, Orn, Leu, 0.708; Pro, Tyr, Leu, 0.708; Pro, Lys, Ile, 0.708; Tyr, Val, Leu, 0.708; Orn, Lys, Ile, 0.708; Orn, Leu, Phe, 0.708; Gly, Orn, Ile, 0.707; His, Ala, Leu, 0.707; His, Lys, Leu, 0.707; Thr, Ala, Leu, 0.707; Thr, Cit, Leu, 0.707; Thr, Tyr, Val, 0.707; Cit, Leu, Trp, 0.707; Arg, Pro, Leu, 0.707; Tyr, Val, Lys, 0.707; Met, Orn, Ile, 0.707; Ser, Val, Leu, 0.707; Gly, Ile, Trp, 0.707; His, Val, Leu, 0.707; Thr, Ala, Ile, 0.707; Thr, Ile, Leu, 0.707; Ala, Arg, Leu, 0.707; Cit, Lys, Leu, 0.707; Arg, Met, Ile, 0.707; Arg, Ile, Trp, 0.707; Tyr, Val, Orn, 0.707; Val, Orn, Leu, 0.707; Orn, Lys, Leu, 0.707; Ile, Phe, Trp, 0.707; Ser, Lys, Leu, 0.706; Gly, Arg, Leu, 0.706; Ala, Cit, Leu, 0.706; Met, Ile, Trp, 0.706; Orn, Ile, Trp, 0.706; Ser, Ile, Leu, 0.705; Gly, Ala, Ile, 0.705; Gly, Pro, Ile, 0.705; Gly, Orn, Leu, 0.705; Gly, Leu, Trp, 0.705; His, Cit, Leu, 0.705; Ala, Val, Ile, 0.705; Pro, Met, Leu, 0.705; Val, Ile, Leu, 0.705; Val, Ile, Trp, 0.705; Ser, Ala, Leu, 0.705; Ser, Cit, Leu, 0.705; Ser, Tyr, Val, 0.705; Ser, Lys, Ile, 0.705; Gly, Thr, Ile, 0.705; His, Val, Orn, 0.705; Thr, Orn, Ile, 0.705; Thr, Leu, Trp, 0.705; Cit, Val, Lys, 0.705; Cit, Met, Leu, 0.705; Cit, Leu, Phe, 0.705; Val, Met, Lys, 0.705; Val, Met, Ile, 0.705; Orn, Leu, Trp, 0.705; Ser, Met, Ile, 0.704; Gly, Ala, Leu, 0.704; Gly, Met, Leu, 0.704; Gln, His, Thr, 0.704; Thr, Val, Ile, 0.704; Thr, Met, Ile, 0.704; Thr, Ile, Trp, 0.704; Ala, Pro, Ile, 0.704; Ala, Ile, Trp, 0.704; Arg, Pro, Lys, 0.704; Pro, Orn, Ile, 0.704; Pro, Ile, Trp, 0.704; Val, Met, Leu, 0.704; Val, Lys, Trp, 0.704; Met, Orn, Leu, 0.704; Orn, Ile, Leu, 0.704; Ser, Gly, Leu, 0.703; Ser, Orn, Leu, 0.703; Gly, His, Leu, 0.703; Gly, Thr, Leu, 0.703; His, Val, Met, 0.703; Thr, Arg, Ile, 0.703; Thr, Tyr, Leu, 0.703; Thr, Val, Lys, 0.703; Thr, Met, Leu, 0.703; Pro, Leu, Trp, 0.703; Ser, Ala, Ile, 0.703; Gly, Pro, Leu, 0.703; Gly, Val, Ile, 0.703; Thr, Pro, Ile, 0.703; Thr, Val, Leu, 0.703; Thr, Lys, Leu, 0.703; Ala, Val, Leu, 0.703; Pro, Val, Leu, 0.703; Met, Leu, Trp, 0.703; Ser, Val, Lys, 0.702; Asn, His, Tyr, 0.702; His, Tyr, Leu, 0.702; His, Met, Leu, 0.702; Cit, Arg, Leu, 0.702; Tyr, Orn, Leu, 0.702; Val, Orn, Ile, 0.702; Gln, His, Cit, 0.702; Gln, Ala, Lys, 0.702; His, Ala, Val, 0.702; His, Val, Trp, 0.702; Ala, Lys, Leu, 0.702; Arg, Val, Leu, 0.702; Pro, Val, Ile, 0.702; Ser, Val, Ile, 0.701; Ser, Ile, Trp, 0.701; Asn, His, Lys, 0.701; Gly, Val, Lys, 0.701; Gln, Tyr, Lys, 0.701; His, Orn, Leu, 0.701; Ala, Orn, Leu, 0.701; Val, Orn, Lys, 0.701; Ser, Arg, Leu, 0.7; Ser, Met, Leu, 0.7; Gly, Gln, His, 0.7; Gln, His, Arg, 0.7; Gln, Pro, Tyr, 0.7; His, Arg, Val, 0.7; Cit, Pro, Leu, 0.7; Ser, Gln, His, 0.7; Ser, Arg, Ile, 0.7; Asn, Gln, Val, 0.7; Cit, Orn, Leu, 0.7; Arg, Leu, Trp, 0.7; Ser, Gly, Ile, 0.699; Ser, Thr, Ile, 0.699; Asn, Val, Orn, 0.699; Gln, His, Phe, 0.699; Gln, Pro, Lys, 0.699; Gln, Val, Met, 0.699; Gln, Met, Lys, 0.699; His, Arg, Leu, 0.699; His, Pro, Leu, 0.699; Thr, Pro, Leu, 0.699; Pro, Orn, Leu, 0.699; Pro, Lys, Leu, 0.699; Ser, His, Val, 0.698; Ser, Tyr, Leu, 0.698; Gln, Val, Orn, 0.698; Ser, Pro, Ile, 0.698; Asn, Tyr, Lys, 0.698; Asn, Val, Met, 0.698; Gly, Gln, Val, 0.698; Gln, Cit, Val, 0.698; Gln, Val, Phe, 0.698; His, Pro, Val, 0.698; Ser, His, Leu, 0.697; Ser, Pro, Leu, 0.697; Thr, Arg, Leu, 0.697; Ala, Pro, Leu, 0.697; Arg, Pro, Val, 0.697; Pro, Val, Phe, 0.697; Ser, Asn, Val, 0.697; Ser, Orn, Ile, 0.697; Asn, Gln, Lys, 0.697; Asn, Val, Phe, 0.697; Gln, Thr, Val, 0.697; Thr, Orn, Leu, 0.697; Cit, Pro, Val, 0.697; Ser, Gln, Val, 0.696; Asn, Cit, Val, 0.696; Asn, Pro, Val, 0.696; Gly, Gln, Lys, 0.696; Gln, Arg, Val, 0.696; Gln, Pro, Met, 0.696; Pro, Val, Lys, 0.696; Ser, Thr, Leu, 0.695; Asn, Arg, Val, 0.695; Gln, Pro, Val, 0.695; Gly, His, Val, 0.695; Gln, Val, Trp, 0.695; Gln, Orn, Lys, 0.695; His, Thr, Leu, 0.694; Gln, Cit, Pro, 0.693; Cit, Val, Phe, 0.693; Arg, Val, Phe, 0.693; Asn, Gly, Val, 0.693; Asn, Ala, Val, 0.693; Gln, Cit, Lys, 0.693; His, Thr, Val, 0.693; Arg, Met, Leu, 0.693; Ser, Gln, Lys, 0.692; Asn, Tyr, Trp, 0.692; Gly, Cit, Val, 0.692; Gly, Arg, Val, 0.692; Gln, Lys, Phe, 0.692; Asn, Thr, Val, 0.691; Asn, Val, Trp, 0.691; Cit, Arg, Val, 0.691; Val, Orn, Phe, 0.691; Asn, Gln, His, 0.691; Gln, His, Trp, 0.691; Gln, Ala, Val, 0.691; Thr, Val, Orn, 0.691; Ala, Val, Lys, 0.691; Cit, Val, Orn, 0.691; Gln, Lys, Trp, 0.69; Gln, Thr, Lys, 0.69; Gln, Arg, Pro, 0.69; Gln, Arg, Lys, 0.689; Gly, Gln, Pro, 0.688; Gly, Val, Phe, 0.688; His, Arg, Tyr, 0.688; Ala, Val, Phe, 0.688; Val, Orn, Trp, 0.688; Ser, Cit, Val, 0.688; Thr, Val, Phe, 0.688; Ala, Cit, Val, 0.688; Cit, Val, Met, 0.688; Cit, Val, Trp, 0.688; Ser, Pro, Val, 0.687; Ser, Val, Orn, 0.687; Asn, Gln, Pro, 0.687; Gly, Val, Orn, 0.687; Gly, Pro, Val, 0.686; Thr, Cit, Val, 0.686; Ala, Arg, Val, 0.686; Arg, Val, Orn, 0.686; Pro, Val, Met, 0.686; Pro, Val, Orn, 0.686; Val, Met, Orn, 0.686; Ser, Arg, Val, 0.686; Gly, Gln, Met, 0.686; Arg, Val, Met, 0.686; Gly, Val, Met, 0.685; Gln, Thr, Pro, 0.685; Gln, Thr, Met, 0.685; Arg, Val, Trp, 0.685; Val, Met, Trp, 0.685; Ser, Gln, Pro, 0.684; Thr, Arg, Val, 0.684; Ser, Gln, Met, 0.683; Asn, His, Orn, 0.683; Gly, Val, Trp, 0.683; Gln, Ala, Met, 0.683; Gln, Pro, Phe, 0.683; Gln, Met, Phe, 0.683; Thr, Pro, Val, 0.683; Ala, Val, Orn, 0.683; Ser, Thr, Val, 0.683; Ser, Ala, Val, 0.683; Asn, Lys, Trp, 0.683; Gln, Tyr, Orn, 0.683; Val, Met, Phe, 0.683; Ser, Val, Phe, 0.683; Gly, Ala, Val, 0.682; Arg, Orn, Lys, 0.682; Asn, Pro, Tyr, 0.681; Gly, Thr, Val, 0.681; Asn, Gln, Tyr, 0.681; Ala, Val, Trp, 0.681; Ser, Val, Met, 0.68; His, Cit, Tyr, 0.68; Thr, Val, Trp, 0.68; Ala, Val, Met, 0.68; Pro, Val, Trp, 0.68; Gln, Ala, Tyr, 0.679; Ala, Pro, Val, 0.679; Gly, Gln, Tyr, 0.679; Ser, Gly, Val, 0.678; His, Tyr, Met, 0.678; Thr, Val, Met, 0.678; Val, Phe, Trp, 0.678; Ser, Val, Trp, 0.677; Asn, His, Ala, 0.677; Asn, Ala, Tyr, 0.677; As

n, Cit, Tyr, 0.676; Gln, Cit, Tyr, 0.676; Gln, Tyr, Met, 0.676; Gln, Tyr, Trp, 0.676; His, Thr, Tyr, 0.676; Gln, Arg, Tyr, 0.676; Asn, His, Trp, 0.676; Gln, Arg, Met, 0.676; Gln, Thr, Tyr, 0.675; Thr, Ala, Val, 0.675; Asn, Arg, Lys, 0.674; Gln, Tyr, Phe, 0.674; Ser, Gln, Tyr, 0.673; His, Arg, Lys, 0.673; Asn, Gln, Met, 0.672; Asn, Met, Lys, 0.672; Gln, Cit, Met, 0.672; Asn, Gly, Lys, 0.671; Asn, Tyr, Orn, 0.671; Asn, Orn, Lys, 0.671; Asn, Arg, Tyr, 0.67; Gly, His, Tyr, 0.67; Asn, Gly, Tyr, 0.67; Ser, Asn, Tyr, 0.669; Asn, Thr, Lys, 0.669; Asn, Pro, Lys, 0.669; Asn, Tyr, Met, 0.669; Asn, Tyr, Phe, 0.669; Ser, His, Tyr, 0.666; Asn, Thr, Tyr, 0.666; His, Met, Lys, 0.666; His, Lys, Trp, 0.666; Gln, Met, Orn, 0.665; His, Arg, Orn, 0.665; His, Tyr, Lys, 0.665; Cit, Arg, Lys, 0.665; Tyr, Met, Lys, 0.665; Ser, Asn, Lys, 0.664; His, Tyr, Orn, 0.664; Arg, Pro, Tyr, 0.664; Arg, Tyr, Orn, 0.664; Asn, Lys, Phe, 0.663; Gln, Pro, Orn, 0.663; Gln, Ala, Pro, 0.663; Gln, Pro, Trp, 0.663; His, Tyr, Phe, 0.663; His, Tyr, Trp, 0.663; Arg, Lys, Trp, 0.663; Gly, Arg, Tyr, 0.662; His, Pro, Lys, 0.662; Cit, Tyr, Orn, 0.662; Asn, His, Pro, 0.66; Ala, Arg, Lys, 0.66; Thr, Arg, Lys, 0.66; Cit, Arg, Tyr, 0.658; Asn, Cit, Lys, 0.658; His, Thr, Lys, 0.658; His, Ala, Arg, 0.658; His, Ala, Phe, 0.658; Ser, His, Lys, 0.657; Gln, Ala, Trp, 0.657; Cit, Tyr, Trp, 0.657; Asn, Ala, Lys, 0.657; Arg, Lys, Phe, 0.657; Gly, His, Lys, 0.656; His, Cit, Pro, 0.656; His, Lys, Phe, 0.656; Cit, Tyr, Lys, 0.656; Arg, Tyr, Trp, 0.656; His, Thr, Cit, 0.655; His, Ala, Pro, 0.655; His, Ala, Tyr, 0.655; His, Arg, Pro, 0.655; Pro, Tyr, Met, 0.655; Pro, Lys, Trp, 0.655; Ser, His, Orn, 0.655; Asn, Ala, Met, 0.655; His, Arg, Trp, 0.655; Ser, His, Ala, 0.654; Asn, His, Phe, 0.654; Gly, His, Phe, 0.654; His, Met, Phe, 0.654; Cit, Pro, Tyr, 0.654; Ser, His, Thr, 0.653; Gln, Ala, Phe, 0.653; His, Thr, Pro, 0.653; His, Cit, Lys, 0.653; Thr, Tyr, Lys, 0.653; Ala, Arg, Tyr, 0.653; Cit, Pro, Lys, 0.653; Arg, Met, Lys, 0.653; Gln, Met, Trp, 0.652; His, Cit, Met, 0.652; His, Cit, Trp, 0.652; Gln, Thr, Ala, 0.651; Gln, Ala, Cit, 0.651; His, Thr, Phe, 0.651; His, Orn, Lys, 0.651; Arg, Tyr, Met, 0.651; Ser, His, Pro, 0.65; Asn, His, Cit, 0.65; Asn, His, Met, 0.65; Asn, Ala, Trp, 0.65; His, Pro, Tyr, 0.65; His, Pro, Orn, 0.65 [2. Three-variable formula containing amino acids]
Gln, His, Ile, 0.752; Gln, Lys, Ile, 0.745; Asn, Lys, Ile, 0.744; Gln, Leu, Phe, 0.741; Tyr, Leu, 0.74; Gln, Lys, Leu, 0.74; Asn, Gln, Ile, 0.739; Gln, Ile, Phe, 0.739; Ile, 0.737; Gln, Orn, Leu, 0.736; Gln, Ile, Leu, 0.736; Gln, His, Tyr, 0.735; Arg, Tyr, Lys, 0.735; Asn, Lys, Leu, 0.733; Asn, Tyr, Leu, 0.733; Gln, Pro, Ile, 0.733; Asn, Val, Lys, 0.732; Tyr, Ile, Phe, 0.732; Gln, Ile, Trp, 0.731; Gln, Arg, Ile, 0.731; His, Ile, Phe, 0.73; Tyr, Leu, Phe, 0.73; Orn, Ile, 0.73; Asn, Ile, Leu, 0.729; Gln, Ala, Leu, 0.729; Asn, Gly, Leu, 0.728; Asn, Cit, Ile, 0.728; Leu, 0.727; Gln, Val, Lys, 0.727; Ser, Gln, Ile, 0.726; Ser, Gln, Leu, 0.726; Asn, Leu, Phe, 0.726; Arg, Tyr, Ile, 0.726; Asn, His, Val, 0.7 25; Gln, Met, Ile, 0.725; His, Tyr, Ile, 0.724; Gln, His, Lys, 0.724; Gln, Leu, Trp, 0.724; Gln, Pro, Leu, 0.723; Gln, Tyr, Val, 0.723; Gln, Thr, Leu, 0.723; Cit, Ile, Phe, 0.723; Thr, Ile, 0.721; Asn, Ile, Trp, 0.721; Gln, His, Leu, 0.721; Cit, Lys, Ile, 0.721; Tyr, Ile, Trp, 0.721; Asn, Orn, Leu, 0.721; Asn, Ile, Phe, 0.721; Asn, Met, Leu, 0.72; Gln, Cit, Leu, 0.72; Arg, Tyr, Leu, 0.72; Tyr, Orn, Ile, 0.72; Ser, Asn, Leu, 0.719; Asn, Leu, Trp, 0.719; Gly, Tyr, Ile, 0.719; Thr, Tyr, Ile, 0.719; Cit, Arg, Ile, 0.719; Cit, Tyr, Val, 0.719; Cit, Met, Ile, 0.719; Pro, Tyr, Ile, 0.719; Cit, Ile, 0.718; Cit, Pro, Ile, 0.718; Arg, Val, Lys, 0.718; Lys, Ile, Phe, 0.718; Asn, His, Leu, 0.717; Leu, 0.717; Arg, Ile, Leu, 0.717; Asn, Gly, I Asn, Orn, Ile, 0.717; Gln, His, Val, 0.717; Gln, Val, Leu, 0.717; His, Arg, Ile, 0.717; His, Met, Ile, 0.717; Ser, Asn, Ile, 0.716; Asn, Val, Ile, 0.716; Ala, Ile, Phe, 0.716; Tyr, Val, Met, 0.716; Gly, Cit, Ile, 0.716; Thr, Cit, Ile, 0.716; Lys, Leu, Phe, 0.716; Asn, Ala, Leu, 0.715; Asn, Cit, Leu, 0.715; Asn, Arg, Ile, 0.715; Leu, Phe, 0.715; Thr, Ile, Phe, 0.715; Thr, Leu, Phe, 0.715; Cit, Orn, Ile, 0.715; Cit, Ile, Trp, 0.715; Ile, 0.714; Gly, Cit, Leu, 0.714; Gly, Ile, Phe, 0.714; Ala, Met, Ile, 0.714; Cit, Val, Ile, 0.714; Pro, Ile, Phe, 0.714; Val, Leu, Phe, 0.714; Orn, Ile, Phe, 0.714; Asn, Met, Ile, 0.714; Gly, Leu, Phe, 0.714; Cit, Tyr, Leu, 0.714; Cit, Val, Leu, 0.714; Arg, Leu, Phe, 0.714; Lys, Ile, Leu, 0.714; Asn, Pro, Ile, 0.713; Cit, Ile, 0.713; His, Pro, Ile, 0.713; His, Lys, Ile, 0.713; Cit, Ile, Leu, 0.713; Arg, Ile, Phe, 0.713; Val, Lys, Ile, 0.713; Ser, Tyr, Ile, 0.712; Orn, Ile, 0.712; His, Ile, Leu, 0.712; Ile, Leu, Trp, 0.712; Ser, His, Ile, 0.712; His, Ile, Trp, 0.712; Trp, 0.712; Arg, Tyr, Val, 0.712; Tyr, Ile, Leu, 0.712; Met, Ile, Phe, 0.712; Ser, Cit, Ile, 0.711; Pro, Tyr, Val, 0.711; Tyr, Val, Phe, 0.711; Val, Leu, Trp, 0.711; Ser, Leu, Phe, 0.71; Gly, Lys, Ile, 0.71; Pro, Leu, Phe, 0.71; Lys, Ile, Trp, 0.71; Lys, Leu, Trp, 0.71; Leu, Phe, Trp, 0.71; Thr, Lys, Ile, 0.71; Ile, Leu, 0.71; Pro, Met, Ile, 0.71; Met, Lys, Leu, 0.71; Gln, His, Met, 0.709; Ala, Leu, Phe, 0.709; Leu, 0.709; Tyr, Leu, Trp, 0.709; Met, Ile, Leu, 0.709; Met, Leu, Phe, 0.709; Ser, Ile, Phe, 0.709; His, Thr, Ile, 0.709; His, Val, Ile, 0.709; Ala, Tyr, Leu, 0.709; Ala, Orn, Ile, 0.709; Arg, Pro, Ile, 0.709; Arg, Orn, Ile, 0.709; Tyr, Val, Trp, 0.709; Lys, Phe, 0.709; Ser, Leu, Trp, 0.708; Gly, Arg, Ile, 0.708; Gly, Met, Ile, 0.708; Gly, Ile, Leu, 0.708; His, Val, Phe, 0.708; His, Leu, Trp, 0.708; Ala, Lys, Ile, 0.708; Arg, Orn, Leu, 0.708; Pro, Tyr, Leu, 0.708; Orn, Lys, Ile, 0.708; Orn, Leu, Phe, 0.708; Gly, Orn, Ile, 0.707; His, Ala, Leu, 0.707; His, Lys, Leu, 0.707; Thr, Ala, Leu, 0.707; Thr, Cit, Leu, 0.707; Thr, Tyr, Val, 0.707; Cit, Leu, Trp, 0.707; Arg, Pro, Leu, 0.707; Orn, Ile, 0.707; Ser, Val, Leu, 0.707; Gly, Ile, Trp, 0.707; His, Val, Leu, 0.707; Thr, Ala, Ile, 0.707; Leu, 0.707; Cit, Lys, Leu, 0.707; Arg, Met, Ile, 0.707; Arg, Ile, Trp, 0.707; Tyr, Val, Orn, 0.707; 0.707; Ile, Phe, Trp, 0.707; Ser, Lys, Leu, 0.706; Gly, Arg, Leu, 0.706; Ala, Cit, Leu, 0.706; Met, Ile, Trp, 0.706; Orn, Ile, Trp, 0.706; Gly, Pro, Ile, 0.705; Gly, Orn, Leu, 0.705; Gly, Leu, Trp, 0.705; His, Cit, Leu, 0.705; Ala, Val, Ile, 0.705; Val, Ile, Leu, 0.705; Val, Ile, Trp, 0.705; Ser, Ala, Leu, 0.705; Ser, Cit, Leu, 0.705; Ser, Tyr, Val, 0.705; Thr, Ile, 0.705; His, Val, Orn, 0.705; Thr, Orn, Ile, 0.705; Thr, Leu, Trp, 0.705; Cit, Val, Lys, 0.705; Phe, 0.705; Val, Met, Lys, 0.705; Val, Met, Ile, 0.705; Orn, Leu, Trp, 0.705; Ser, Met, Ile, 0.704; Thr, Val, Ile, 0.704; Thr, Met, Ile, 0.704; Thr, Ile, Trp, 0.704; Ala, Pro, Ile, 0.704; Ala, Ile, Trp, 0.704; Arg, Pro, Lys, 0.704; Pro, Orn, Ile, 0.704; Pro, Ile, Trp, 0.704; Val, Met, Leu, 0.704; Val, Lys, Trp, 0.704; Ile, Leu, 0.704; Ser, Gly, Leu, 0.70 3; Ser, Orn, Leu, 0.703; Gly, His, Leu, 0.703; Gly, Thr, Leu, 0.703; His, Val, Met, 0.703; Thr, Val, Lys, 0.703; Thr, Met, Leu, 0.703; Pro, Leu, Trp, 0.703; Ser, Ala, Ile, 0.703; Gly, Pro, Leu, 0.703; Pro, Ile, 0.703; Thr, Val, Leu, 0.703; Thr, Lys, Leu, 0.703; Ala, Val, Leu, 0.703; Pro, Val, Leu, 0.703; Lys, 0.702; Asn, His, Tyr, 0.702; His, Tyr, Leu, 0.702; His, Met, Leu, 0.702; Cit, Arg, Leu, 0.702; Gln, His, Cit, 0.702; Gln, Ala, Lys, 0.702; His, Ala, Val, 0.702; His, Val, Trp, 0.702; Ala, Lys, Leu, 0.702; Pro, Val, Ile, 0.702; Ser, Val, Ile, 0.701; Ser, Ile, Trp, 0.701; Asn, His, Lys, 0.701; Gly, Val, Lys, 0.701; Orn, Leu, 0.701; Ala, Orn, Leu, 0.701; Val, Orn, Lys, 0.701; Ser, Arg, Leu, 0.7; Ser, Met, Leu, 0.7; Arg, 0.7; Gln, Pro, Tyr, 0.7; His, Arg, Val, 0. Ser, Gln, His, 0.7; Ser, Arg, Ile, 0.7; Asn, Gln, Val, 0.7; Cit, Orn, Leu, 0.7; Arg, Leu, Trp, 0.7; Ser, Gly, Ile, 0.699; Ser, Thr, Ile, 0.699; Asn, Val, Orn, 0.699; Gln, His, Phe, 0.699; Met, Lys, 0.699; His, Arg, Leu, 0.699; His, Pro, Leu, 0.699; Thr, Pro, Leu, 0.699; Pro, Orn, Leu, 0.699; Ser, Tyr, Leu, 0.698; Gln, Val, Orn, 0.698; Ser, Pro, Ile, 0.698; Asn, Tyr, Lys, 0.698; Asn, Val, Met, 0.698; Gln, Cit, Val, 0.698; Gln, Val, Phe, 0.698; His, Pro, Val, 0.698; Ser, His, Leu, 0.697; Ser, Pro, Leu, 0.697; Ala, Pro, Leu, 0.697; Arg, Pro, Val, 0.697; Pro, Val, Phe, 0.697; Ser, Asn, Val, 0.697; Ser, Orn, Ile, 0.697; Val, Phe, 0.697; Gln, Thr, Val, 0.697; Thr, Orn, Leu, 0.697; Cit, Pro, Val, 0.697; Ser, Gln, Val, 0.696; Val, 0.696; Gly, Gln, Lys, 0.696; Gln, Arg, Val, 0.69 6; Gln, Pro, Met, 0.696; Pro, Val, Lys, 0.696; Ser, Thr, Leu, 0.695; Asn, Arg, Val, 0.695; Gln, Val, Trp, 0.695; Gln, Orn, Lys, 0.695; His, Thr, Leu, 0.694; Gln, Cit, Pro, 0.693; Cit, Val, Phe, 0.693; Gly, Val, 0.693; Asn, Ala, Val, 0.693; Gln, Cit, Lys, 0.693; His, Thr, Val, 0.693; Arg, Met, Leu, 0.693; Trp, 0.692; Gly, Cit, Val, 0.692; Gly, Arg, Val, 0.692; Gln, Lys, Phe, 0.692; Asn, Thr, Val, 0.691; Val, Orn, Phe, 0.691; Asn, Gln, His, 0.691; Gln, His, Trp, 0.691; Gln, Ala, Val, 0.691; Thr, Val, Orn, 0.691; Cit, Val, Orn, 0.691; Gln, Lys, Trp, 0.69; Gln, Thr, Lys, 0.69; Gln, Arg, Pro, 0.69; Val, Phe, 0.688; His, Arg, Tyr, 0.688; Ala, Val, Phe, 0.688; Val, Orn, Trp, 0.688; Ser, Cit, Val, 0.688; Val, 0.688; Cit, Val, Met, 0.688; Cit, Val, Ser, Pro, Val, 0.687; Ser, Val, Orn, 0.687; Asn, Gln, Pro, 0.687; Gly, Val, Orn, 0.687; Gly, Pro, Val, 0.686; Ala, Arg, Val, 0.686; Arg, Val, Orn, 0.686; Pro, Val, Met, 0.686; Pro, Val, Orn, 0.686; Val, Met, Orn, 0.686; Gly, Gln, Met, 0.686; Arg, Val, Met, 0.686; Gly, Val, Met, 0.685; Gln, Thr, Pro, 0.685; Met, Trp, 0.685; Ser, Gln, Pro, 0.684; Thr, Arg, Val, 0.684; Ser, Gln, Met, 0.683; Asn, His, Orn, 0.683; Met, 0.683; Gln, Pro, Phe, 0.683; Gln, Met, Phe, 0.683; Thr, Pro, Val, 0.683; Asn, Lys, Trp, 0.683; Gln, Tyr, Orn, 0.683; Val, Met, Phe, 0.683; Ser, Val, Phe, 0.683; Gly, Ala, Val, 0.682; Asn, Pro, Tyr, 0.681; Gly, Thr, Val, 0.681; Asn, Gln, Tyr, 0.681; Ala, Val, Trp, 0.681; Ser, Val, Met, 0.68; Val, Trp, 0.68; Ala, Val, Met, 0.68; Pr o, Val, Trp, 0.68; Gln, Ala, Tyr, 0.679; Ala, Pro, Val, 0.679; Gly, Gln, Tyr, 0.679; Ser, Gly, Val, 0.678; Val, Met, 0.678; Val, Phe, Trp, 0.678; Ser, Val, Trp, 0.677; Asn, His, Ala, 0.677; Asn, Ala, Tyr, 0.677;

n, Cit, Tyr, 0.676; Gln, Cit, Tyr, 0.676; Gln, Tyr, Met, 0.676; Gln, Tyr, Trp, 0.676; His, Thr, Tyr, 0.676; His, Trp, 0.676; Gln, Arg, Met, 0.676; Gln, Thr, Tyr, 0.675; Thr, Ala, Val, 0.675; Asn, Arg, Lys, 0.674; Tyr, 0.673; His, Arg, Lys, 0.673; Asn, Gln, Met, 0.672; Asn, Met, Lys, 0.672; Asn, Orn, Lys, 0.671; Asn, Arg, Tyr, 0.67; Gly, His, Tyr, 0.67; Asn, Gly, Tyr, 0.67; Ser, Asn, Tyr, 0.669; Asn, Pro, Lys, 0.669; Asn, Tyr, Met, 0.669; Asn, Tyr, Phe, 0.669; Ser, His, Tyr, 0.666; Asn, Thr, Tyr, 0.666; Lys, Trp, 0.666; Gln, Met, Orn, 0.665; His, Arg, Orn, 0.665; His, Tyr, Lys, 0.665; Cit, Arg, Lys, 0.665; Lys, 0.664; His, Tyr, Orn, 0.664; Arg, Pro, Tyr, 0.664; Arg, Tyr, Orn, 0.664; Asn, Lys, Phe, 0.663; 0.663; Gln, Pro, Trp, 0.663; His, Tyr, Phe, His, Tyr, Trp, 0.663; Arg, Lys, Trp, 0.663; Gly, Arg, Tyr, 0.662; His, Pro, Lys, 0.662; Cit, Tyr, Orn, 0.662; Ala, Arg, Lys, 0.66; Thr, Arg, Lys, 0.66; Cit, Arg, Tyr, 0.658; Asn, Cit, Lys, 0.658; His, Thr, Lys, 0.658; Ala, Phe, 0.658; Ser, His, Lys, 0.657; Gln, Ala, Trp, 0.657; Cit, Tyr, Trp, 0.657; Asn, Ala, Lys, 0.657; Lys, 0.656; His, Cit, Pro, 0.656; His, Lys, Phe, 0.656; Cit, Tyr, Lys, 0.656; Arg, Tyr, Trp, 0.656; His, Ala, Tyr, 0.655; His, Arg, Pro, 0.655; Pro, Tyr, Met, 0.655; Pro, Lys, Trp, 0.655; Ser, His, Orn, 0.655; His, Arg, Trp, 0.655; Ser, His, Ala, 0.654; Asn, His, Phe, 0.654; Gly, His, Phe, 0.654; His, Met, Phe, 0.654; His, Thr, 0.653; Gln, Ala, Phe, 0.653; His, Thr, Pro, 0.653; His, Cit, Lys, 0.653; Thr, Tyr, Lys, 0.653; Lys, 0.653; Arg, Met, Lys, 0.653; Gln, M et, Trp, 0.652; His, Cit, Met, 0.652; His, Cit, Trp, 0.652; Gln, Thr, Ala, 0.651; Gln, Ala, Cit, 0.651; Lys, 0.651; Arg, Tyr, Met, 0.651; Ser, His, Pro, 0.65; Asn, His, Cit, 0.65; His, Pro, Orn, 0.65; 0.65;
［３．アミノ酸を含む４変数の式］
Gln, His, Tyr, Ile, 0.765; Gln, His, Ile, Phe, 0.763; Gln, Tyr, Ile, Phe, 0.761; Asn, Gln, His, Ile, 0.76; Gln, His, Cit, Ile, 0.759; Gln, Arg, Lys, Ile, 0.759; Asn, Arg, Lys, Ile, 0.757; His, Tyr, Ile, Phe, 0.755; Gln, His, Met, Ile, 0.754; Asn, Cit, Lys, Ile, 0.753; Gln, His, Arg, Ile, 0.753; Gln, Tyr, Leu, Phe, 0.753; Asn, Gln, Lys, Ile, 0.752; Gln, His, Val, Ile, 0.752; Arg, Tyr, Lys, Ile, 0.752; Gly, Gln, Tyr, Ile, 0.752; Gln, His, Pro, Ile, 0.752; Gln, His, Ile, Leu, 0.752; Gln, Tyr, Leu, Trp, 0.752; Asn, Gln, Lys, Leu, 0.751; Gly, Gln, Tyr, Leu, 0.751; Gln, His, Ala, Ile, 0.751; Gln, His, Ile, Trp, 0.75; Thr, Tyr, Leu, Phe, 0.75; Gly, Gln, Lys, Ile, 0.75; Asn, Thr, Lys, Ile, 0.749; Gly, Gln, His, Ile, 0.749; Gln, Cit, Tyr, Ile, 0.749; Gln, Tyr, Ile, Leu, 0.749; Gln, His, Thr, Ile, 0.749; Gln, Tyr, Lys, Leu, 0.749; Gln, Ile, Leu, Phe, 0.749; His, Tyr, Met, Ile, 0.749; Arg, Lys, Ile, Phe, 0.749; Asn, Met, Lys, Ile, 0.748; Gln, His, Tyr, Leu, 0.748; Gln, Cit, Orn, Ile, 0.748; Gln, Lys, Ile, Phe, 0.748; Asn, Cit, Tyr, Ile, 0.747; Gln, Val, Lys, Ile, 0.747; Gln, Lys, Ile, Leu, 0.747; Gln, Lys, Ile, Trp, 0.747; Cit, Tyr, Lys, Ile, 0.747; Asn, His, Lys, Ile, 0.747; Asn, His, Ile, Phe, 0.747; Asn, Lys, Ile, Leu, 0.747; Gln, His, Orn, Ile, 0.747; Gln, Tyr, Lys, Ile, 0.747; Ser, Gln, Tyr, Ile, 0.746; Ser, Gln, Lys, Ile, 0.746; Asn, His, Tyr, Ile, 0.746; Asn, Tyr, Leu, Phe, 0.746; Gln, His, Lys, Ile, 0.746; Gln, Thr, Lys, Ile, 0.746; Gln, Ala, Cit, Ile, 0.746; Gln, Cit, Lys, Ile, 0.746; Gln, Orn, Leu, Phe, 0.746; Ser, Gln, His, Ile, 0.745; Asn, Gly, Tyr, Leu, 0.745; Asn, Gln, Ile, Leu, 0.745; Asn, Gln, Leu, Phe, 0.745; Asn, His, Val, Lys, 0.745; Gly, Cit, Tyr, Ile, 0.745; Cit, Tyr, Val, Ile, 0.745; Cit, Tyr, Orn, Ile, 0.745; Cit, Tyr, Ile, Phe, 0.745; Asn, Gly, Lys, Ile, 0.745; Gln, Met, Lys, Ile, 0.745; Gln, Orn, Lys, Ile, 0.745; Tyr, Met, Lys, Ile, 0.745; Tyr, Lys, Ile, Phe, 0.745; Asn, Gln, Tyr, Ile, 0.744; Asn, His, Met, Ile, 0.744; Gln, Cit, Pro, Ile, 0.744; His, Cit, Tyr, Ile, 0.744; His, Arg, Tyr, Ile, 0.744; Asn, Orn, Lys, Ile, 0.743; Gly, Gln, Orn, Leu, 0.743; Gln, Thr, Leu, Phe, 0.743; Gln, Arg, Tyr, Ile, 0.743; Gln, Tyr, Met, Ile, 0.743; Asn, Gln, Tyr, Leu, 0.743; Asn, His, Orn, Ile, 0.743; Asn, Lys, Ile, Trp, 0.743; Gly, Gln, Cit, Ile, 0.743; Gly, Gln, Leu, Phe, 0.743; Gln, Cit, Arg, Ile, 0.743; Gln, Lys, Leu, Phe, 0.743; Tyr, Met, Ile, Phe, 0.743; Asn, Gln, Orn, Ile, 0.742; Asn, Gln, Orn, Leu, 0.742; Asn, Gln, Ile, Phe, 0.742; Asn, Lys, Ile, Phe, 0.742; Gln, His, Tyr, Phe, 0.742; Gln, Tyr, Met, Leu, 0.742; Cit, Pro, Tyr, Ile, 0.742; Arg, Pro, Tyr, Lys, 0.742; Ser, Gln, Tyr, Leu, 0.742; Asn, Val, Lys, Ile, 0.742; Gln, His, Orn, Leu, 0.742; Gln, Ala, Tyr, Leu, 0.742; Gln, Cit, Ile, Leu, 0.742; Gln, Cit, Ile, Phe, 0.742; Ala, Cit, Tyr, Ile, 0.742; Ser, Gln, Leu, Phe, 0.741; Asn, His, Ala, Ile, 0.741; Asn, His, Arg, Ile, 0.741; Asn, His, Val, Ile, 0.741; Asn, Tyr, Val, Ile, 0.741; Gln, His, Tyr, Val, 0.741; Gln, Ala, Lys, Ile, 0.741; Gln, Cit, Tyr, Leu, 0.741; Gln, Cit, Ile, Trp, 0.741; Gln, Pro, Lys, Ile, 0.741; Cit, Tyr, Met, Ile, 0.741; Arg, Orn, Lys, Ile, 0.741; Arg, Lys, Ile, Leu, 0.741; Asn, Gln, Val, Lys, 0.74; Asn, Tyr, Met, Leu, 0.74; Asn, Tyr, Lys, Ile, 0.74; Cit, Tyr, Ile, Trp, 0.74; Tyr, Ile, Leu, Phe, 0.74; Tyr, Leu, Phe, Trp, 0.74; Ser, Cit, Tyr, Ile, 0.74; Asn, Arg, Tyr, Ile, 0.74; Asn, Tyr, Lys, Leu, 0.74; Gln, Tyr, Val, Leu, 0.74; Cit, Tyr, Ile, Leu, 0.74; Tyr, Val, Ile, Phe, 0.74; Asn, Pro, Lys, Ile, 0.739; Asn, Tyr, Ile, Leu, 0.739; Asn, Val, Lys, Leu, 0.739; Asn, Lys, Leu, Phe, 0.739; Gln, His, Pro, Tyr, 0.739; Gln, His, Tyr, Lys, 0.739; Gln, Pro, Tyr, Leu, 0.739; Gln, Pro, Ile, Phe, 0.739; Gln, Tyr, Orn, Leu, 0.739; Gln, Tyr, Ile, Trp, 0.739; Gln, Val, Lys, Leu, 0.739; Gln, Leu, Phe, Trp, 0.739; His, Arg, Ile, Phe, 0.739; Ser, Asn, Lys, Leu, 0.738; Ser, Arg, Lys, Ile, 0.738; Asn, Gly, Gln, Leu, 0.738; Asn, His, Ile, Leu, 0.738; Gln, Thr, Tyr, Ile, 0.738; Gln, Thr, Ile, Leu, 0.738; Gln, Val, Leu, Phe, 0.738; Gln, Lys, Leu, Trp, 0.738; Gln, Ile, Leu, Trp, 0.738; Asn, Tyr, Ile, Phe, 0.738; Gln, Thr, Cit, Ile, 0.738; Gln, Thr, Tyr, Leu, 0.738; Gln, Ala, Tyr, Ile, 0.738; Gln, Arg, Tyr, Leu, 0.738; Gln, Orn, Lys, Leu, 0.738; Gln, Orn, Ile, Phe, 0.738; Cit, Arg, Lys, Ile, 0.738; Arg, Tyr, Orn, Lys, 0.738; Arg, Lys, Ile, Trp, 0.738; Tyr, Met, Ile, Leu, 0.738; Tyr, Met, Leu, Phe, 0.738; Asn, Gly, His, Ile, 0.737; Asn, Gly, Lys, Leu, 0.737; Asn, His, Pro, Ile, 0.737; Asn, Arg, Tyr, Leu, 0.737; Asn, Orn, Lys, Leu, 0.737; Gln, Thr, Orn, Leu, 0.737; Gln, Arg, Leu, Phe, 0.737; Gln, Tyr, Val, Ile, 0.737; Gln, Tyr, Val, Trp, 0.737; Gln, Orn, Leu, Trp, 0.737; Gln, Pro, Tyr, Ile, 0.737; Gln, Tyr, Orn, Ile, 0.737; Asn, Gln, Thr, Leu, 0.737; Asn, Gln, Cit, Ile, 0.737; Asn, His, Ile, Trp, 0.737; Asn, Cit, Ile, Leu, 0.737; Gln, Ala, Ile, Leu, 0.737; Gln, Arg, Ile, Leu, 0.737; Gln, Val, Orn, Ile, 0.737; His, Lys, Ile, Phe, 0.737; Cit, Arg, Tyr, Ile, 0.737; Arg, Tyr, Ile, Phe, 0.737; Arg, Met, Lys, Ile, 0.737; Ser, Asn, His, Ile, 0.736; Ser, Gln, Orn, Leu, 0.736; Ser, Gln, Lys, Leu, 0.736; Asn, Gln, His, Tyr, 0.736; Asn, Gln, Pro, Ile, 0.736; Asn, Gln, Val, Leu, 0.736; Asn, His, Thr, Ile, 0.736; Asn, His, Tyr, Val, 0.736; Asn, Tyr, Val, Lys, 0.736; Gly, Tyr, Met, Ile, 0.736; Gln, His, Tyr, Trp, 0.736; Gln, His, Leu, Phe, 0.736; Gln, Cit, Val, Ile, 0.736; Gln, Cit, Leu, Phe, 0.736; Thr, Cit, Tyr, Ile, 0.736; Arg, Ile, Leu, Phe, 0.736; Tyr, Orn, Ile, Phe, 0.736; Tyr, Ile, Phe, Trp, 0.736; Asn, Gln, Arg, Ile, 0.735; Asn, Gln, Val, Ile, 0.735; Asn, Thr, Tyr, Val, 0.735; Asn, Ala, Lys, Ile, 0.735; Asn, Lys, Leu, Trp, 0.735; Gly, Arg, Lys, Ile, 0.735; Gln, Thr, Lys, Leu, 0.735; Gln, Ala, Lys, Leu, 0.735; Gln, Cit, Met, Ile, 0.735; Gln, Val, Ile, Phe, 0.735; Gln, Met, Lys, Leu, 0.735; Gln, Orn, Ile, Leu, 0.735; Thr, Arg, Lys, Ile, 0.735; Ser, Asn, Tyr, Leu, 0.735; Ser, Asn, Lys, Ile, 0.735; Asn, His, Cit, Ile, 0.735; Asn, His, Tyr, Leu, 0.735; Gly, Gln, Tyr, Val, 0.735; Gln, His, Tyr, Orn, 0.735; Gln, Val, Orn, Leu, 0.735; Gln, Met, Ile, Leu, 0.735; His, Ile, Leu, Phe, 0.735; His, Ile, Phe, Trp, 0.735; Thr, Tyr, Ile, Phe, 0.735; Arg, Val, Lys, Ile, 0.735; Pro, Tyr, Met, Ile, 0.735; Tyr, Met, Ile, Trp, 0.735; Asn, Gln, Tyr, Val, 0.734; Asn, Orn, Ile, Leu, 0.734; Gly, Gln, Pro, Ile, 0.734; Gly, Gln, Ile, Phe, 0.734; Gly, Arg, Tyr, Ile, 0.734; Gln, His, Pro, Leu, 0.734; Gln, His, Lys, Leu, 0.734; Gln, Pro, Orn, Ile, 0.734; Gln, Met, Orn, Leu, 0.734; Ala, Tyr, Met, Ile, 0.734; Cit, Arg, Tyr, Lys, 0.734; Cit, Tyr, Leu, Phe, 0.734; Arg, Tyr, Lys, Trp, 0.734; Ser, Asn, Gln, Ile, 0.733; Ser, Asn, Gln, Leu, 0.733; Asn, Gln, Arg, Leu, 0.733; Asn, Ala, Tyr, Leu, 0.733; Asn, Tyr, Met, Ile, 0.733; Gly, Gln, Lys, Leu, 0.733; Gln, His, Cit, Tyr, 0.733; Gln, Thr, Arg, Ile, 0.733; Gln, Ala, Ile, Phe, 0.733; Gln, Ala, Leu, Trp, 0.733; Gln, Cit, Lys, Leu, 0.733; Gln, Pro, Val, Ile, 0.733; Gln, Val, Met, Ile, 0.733; Ala, Arg, Lys, Ile, 0.733; Ala, Tyr, Leu, Phe, 0.733; Cit, Ile, Leu, Phe, 0.733; Arg, Pro, Lys, Ile, 0.733; Pro, Tyr, Ile, Phe, 0.733; Tyr, Lys, Leu, Phe, 0.733; Lys, Ile, Leu, Phe, 0.733; Asn, Gly, Gln, Ile, 0.733; Asn, Gln, Leu, Trp, 0.733; Asn, Thr, Lys, Leu, 0.733; Asn, Arg, Tyr, Val, 0.733; Asn, Tyr, Orn, Ile, 0.733; Asn, Ile, Leu, Phe, 0.733; Gly, Gln, Ile, Leu, 0.733; Gly, Arg, Tyr, Lys, 0.733; Gln, His, Ala, Tyr, 0.733; Gln, His, Ala, Leu, 0.733; Gln, Thr, Ile, Phe, 0.733; Gln, Val, Lys, Phe, 0.733; Gln, Val, Ile, Leu, 0.733; His, Cit, Ile, Phe, 0.733; Cit, Pro, Lys, Ile, 0.733; Arg, Tyr, Val, Lys, 0.733; Ser, Asn, Tyr, Ile, 0.732; Ser, Gln, His, Tyr, 0.732; Ser, Gln, Arg, Ile, 0.732; Asn, Gly, Val, Lys, 0.732; Asn, Gln, Ile, Trp, 0.732; Asn, Cit, Orn, Ile, 0.732; Asn, Cit, Ile, Phe, 0.732; Asn, Tyr, Val, Leu, 0.732; Asn, Tyr, Leu, Trp, 0.732; Asn, Val, Met, Lys, 0.732; Asn, Val, Orn, Lys, 0.732; Asn, Met, Ile, Leu, 0.732; Gln, His, Ala, Lys, 0.732; Gln, Pro, Ile, Leu, 0.732; Gln, Val, Ile, Trp, 0.732; Gln, Ile, Phe, Trp, 0.732; Cit, Lys, Ile, Phe, 0.732; Arg, Tyr, Val, Ile, 0.732; Ser, Asn, Val, Lys, 0.731; Asn, Gly, Tyr, Ile, 0.731; Asn, Gly, Ile, Leu, 0.731; Asn, Gln, Thr, Ile, 0.731; Asn, Gln, Met, Leu, 0.731; Asn, Cit, Tyr, Leu, 0.731; Asn, Val, Lys, Phe, 0.731; Asn, Met, Lys, Leu, 0.731; Gly, Gln, Orn, Ile, 0.731; Gln, His, Cit, Pro, 0.731; Gln, Ala, Met, Leu, 0.731; Gln, Arg, Ile, Phe, 0.731; His, Tyr, Leu, Phe, 0.731; His, Orn, Ile, Phe, 0.731; Ala, Tyr, Ile, Phe, 0.731; Arg, Tyr, Met, Ile, 0.731; Arg, Tyr, Leu, Phe, 0.731; Ser, Gln, Cit, Ile, 0.731; Ser, Arg, Tyr, Ile, 0.731; Asn, Gln, Ala, Leu, 0.731; Asn, His, Lys, Leu, 0.731; Asn, Thr, Val, Lys, 0.731; Gln, His, Thr, Tyr, 0.731; Gln, His, Arg, Tyr, 0.731; Gln, Thr, Val, Ile, 0.731; Gln, Thr, Leu, Trp, 0.731; Gln, Arg, Orn, Leu, 0.731; Gln, Orn, Ile, Trp, 0.731; His, Ala, Ile, Phe, 0.731; His, Val, Ile, Phe, 0.731; Thr, Tyr, Met, Ile, 0.731; Tyr, Val, Met, Ile, 0.731; Tyr, Orn, Leu, Phe, 0.731; Ser, Gln, Ile, Phe, 0.73; Ser, His, Ile, Phe, 0.73; Asn, Gly, Tyr, Val, 0.73; Asn, Gln, Ala, Ile, 0.73; Asn, Pro, Tyr, Ile, 0.73; Asn, Tyr, Val, Met, 0.73; Asn, Tyr, Orn, Leu, 0.73; Gly, Gln, Val, Ile, 0.73; Gly, His, Ile, Phe, 0.73; Gly, Tyr, Met, Leu, 0.73; Gln, His, Pro, Phe, 0.73; Gln, Thr, Ala, Leu, 0.73; Gln, Arg, Tyr, Lys, 0.73; Gln, Arg, Ile, Trp, 0.73; Gln, Pro, Met, Ile, 0.73; Gln, Tyr, Val, Met, 0.73; His, Arg, Lys, Ile, 0.73; Arg, Tyr, Lys, Leu, 0.73; Gln, Ala, Met, Ile, 0.73; Ser, Gln, Val, Ile, 0.73; Ser, Gln, Ile, Leu, 0.73; Ser, Tyr, Ile, Phe, 0.73; Asn, Gln, Met, Ile, 0.73; Asn, Ala, Cit, Ile, 0.73; Asn, Ala, Tyr, Ile, 0.73; Asn, Cit, Val, Lys, 0.73; Asn, Val, Ile, Leu, 0.73; Gln, Ala, Orn, Leu, 0.73; Gln, Arg, Orn, Ile, 0.73; Gln, Tyr, Val, Lys, 0.73; His, Arg, Tyr, Lys, 0.73; Thr, Arg, Tyr, Ile, 0.73; Arg, Tyr, Orn, Leu, 0.73; Ser, Gln, His, Leu, 0.729; Ser, Gln, Thr, Ile, 0.729; Ser, Gln, Orn, Ile, 0.729; Ser, Gln, Leu, Trp, 0.729; Ser, Tyr, Met, Ile, 0.729; Asn, Gly, Cit, Ile, 0.729; Asn, Thr, Tyr, Leu, 0.729; Asn, Arg, Tyr, Lys, 0.729; Asn, Orn, Leu, Phe, 0.729; Gly, Gln, Thr, Ile, 0.729; Gly, Gln, Ala, Ile, 0.729; Gly, Gln, Met, Ile, 0.729; Gly, Tyr, Ile, Phe, 0.729; Gln, Ala, Val, Leu, 0.729; Gln, Ala, Orn, Ile, 0.729; Gln, Ala, Ile, Trp, 0.729; Gln, Arg, Val, Ile, 0.729; Gln

, Pro, Ile, Trp, 0.729; His, Thr, Ile, Phe, 0.729; His, Tyr, Ile, Trp, 0.729; His, Met, Lys, Ile, 0.729; Ser, Gln, Pro, Ile, 0.728; Ser, Gln, Val, Lys, 0.728; Asn, His, Leu, Phe, 0.728; Asn, Thr, Ile, Leu, 0.728; Asn, Ala, Ile, Trp, 0.728; Asn, Cit, Val, Ile, 0.728; Asn, Cit, Lys, Leu, 0.728; Asn, Arg, Lys, Leu, 0.728; Asn, Pro, Tyr, Leu, 0.728; Asn, Pro, Leu, Phe, 0.728; Asn, Ile, Leu, Trp, 0.728; Gly, Gln, His, Tyr, 0.728; Gly, Gln, Arg, Ile, 0.728; Gly, Gln, Ile, Trp, 0.728; Gly, Gln, Leu, Trp, 0.728; Gly, Arg, Tyr, Leu, 0.728; Gln, His, Pro, Lys, 0.728; Gln, His, Tyr, Met, 0.728; Gln, Arg, Pro, Ile, 0.728; Gln, Tyr, Val, Phe, 0.728; His, Ala, Met, Ile, 0.728; His, Pro, Ile, Phe, 0.728; Thr, Tyr, Val, Phe, 0.728; Arg, Pro, Tyr, Ile, 0.728; Arg, Tyr, Orn, Ile, 0.728; Arg, Tyr, Ile, Leu, 0.728; Tyr, Val, Met, Phe, 0.728; Tyr, Met, Orn, Ile, 0.728; Ser, Gly, Gln, Ile, 0.728; Ser, Gln, Ile, Trp, 0.728; Asn, Thr, Ile, Phe, 0.728; Asn, Arg, Ile, Leu, 0.728; Asn, Tyr, Val, Orn, 0.728; Asn, Val, Leu, Phe, 0.728; Gly, Gln, Ala, Leu, 0.728; Gly, Tyr, Leu, Phe, 0.728; Gln, His, Val, Lys, 0.728; Gln, Thr, Val, Lys, 0.728; Gln, Thr, Orn, Ile, 0.728; Gln, Met, Orn, Ile, 0.728; Gln, Met, Ile, Trp, 0.728; Gln, Met, Leu, Phe, 0.728; His, Arg, Met, Ile, 0.728; His, Tyr, Lys, Ile, 0.728; His, Met, Ile, Phe, 0.728; Arg, Tyr, Ile, Trp, 0.728; Ser, Asn, Tyr, Val, 0.727; Ser, Thr, Tyr, Ile, 0.727; Ser, Tyr, Leu, Phe, 0.727; Asn, Gln, His, Val, 0.727; Asn, Gln, His, Leu, 0.727; Asn, Thr, Cit, Ile, 0.727; Asn, Thr, Tyr, Ile, 0.727; Gly, Gln, His, Leu, 0.727; Gly, Gln, Met, Leu, 0.727; Gln, His, Orn, Lys, 0.727; Gln, Thr, Ala, Ile, 0.727; Gln, Ala, Pro, Leu, 0.727; Gln, Pro, Lys, Leu, 0.727; Gln, Pro, Leu, Phe, 0.727; Gln, Tyr, Val, Orn, 0.727; His, Cit, Lys, Ile, 0.727; Ala, Cit, Arg, Ile, 0.727; Ala, Arg, Tyr, Lys, 0.727; Tyr, Met, Lys, Leu, 0.727; Ser, Asn, Orn, Leu, 0.726; Ser, Met, Lys, Ile, 0.726; Asn, Gly, Val, Leu, 0.726; Asn, Gln, His, Lys, 0.726; Asn, His, Pro, Val, 0.726; Asn, His, Val, Met, 0.726; Asn, Ala, Ile, Leu, 0.726; Asn, Arg, Val, Lys, 0.726; Asn, Pro, Tyr, Val, 0.726; Asn, Tyr, Val, Trp, 0.726; Asn, Tyr, Ile, Trp, 0.726; Asn, Val, Lys, Trp, 0.726; Gly, Gln, Thr, Leu, 0.726; Gly, Gln, Val, Lys, 0.726; Gln, Thr, Met, Ile, 0.726; Gln, Cit, Orn, Leu, 0.726; Gln, Met, Leu, Trp, 0.726; Pro, Tyr, Leu, Phe, 0.726; Tyr, Val, Ile, Trp, 0.726; Tyr, Orn, Ile, Trp, 0.726; Val, Lys, Ile, Phe, 0.726; Met, Lys, Ile, Phe, 0.726; Orn, Lys, Ile, Phe, 0.726; Ser, Gly, Gln, Leu, 0.726; Ser, Gln, Ala, Leu, 0.726; Ser, Gln, Met, Ile, 0.726; Asn, Gly, Orn, Leu, 0.726; Asn, Gly, Leu, Phe, 0.726; Asn, Gly, Leu, Trp, 0.726; Asn, Cit, Ile, Trp, 0.726; Asn, Met, Leu, Phe, 0.726; Gln, His, Thr, Leu, 0.726; Gln, Arg, Val, Lys, 0.726; Gln, Pro, Orn, Leu, 0.726; His, Cit, Met, Ile, 0.726; Ala, Arg, Tyr, Ile, 0.726; Arg, Tyr, Lys, Phe, 0.726; Tyr, Val, Met, Leu, 0.726; Tyr, Val, Leu, Phe, 0.726; Ser, Gln, Pro, Leu, 0.725; Asn, Gly, Cit, Leu, 0.725; Asn, Gln, Pro, Leu, 0.725; Asn, Cit, Arg, Ile, 0.725; Asn, Cit, Pro, Ile, 0.725; Gly, Tyr, Orn, Ile, 0.725; Gln, Thr, Tyr, Val, 0.725; Gln, Thr, Ile, Trp, 0.725; Gln, Ala, Arg, Ile, 0.725; Gln, Ala, Arg, Leu, 0.725; Gln, Ala, Val, Ile, 0.725; Gln, Arg, Lys, Leu, 0.725; Gln, Arg, Leu, Trp, 0.725; Gln, Pro, Leu, Trp, 0.725; Gln, Val, Lys, Trp, 0.725; His, Thr, Tyr, Ile, 0.725; His, Arg, Orn, Ile, 0.725; Thr, Tyr, Orn, Ile, 0.725; Cit, Tyr, Val, Orn, 0.725; Cit, Lys, Ile, Trp, 0.725; Arg, Tyr, Leu, Trp, 0.725; Arg, Val, Orn, Lys, 0.725; Val, Met, Lys, Ile, 0.725; Val, Ile, Leu, Phe, 0.725; Asn, Gly, His, Val, 0.724; Asn, Gly, Thr, Leu, 0.724; Asn, Gln, His, Pro, 0.724; Asn, Ala, Lys, Leu, 0.724; Asn, Cit, Met, Ile, 0.724; Asn, Arg, Orn, Leu, 0.724; Asn, Pro, Ile, Leu, 0.724; Gly, Gln, Pro, Leu, 0.724; Gly, Gln, Val, Leu, 0.724; Gln, Arg, Met, Ile, 0.724; Gln, Val, Orn, Lys, 0.724; Thr, Tyr, Ile, Trp, 0.724; Ala, Ile, Leu, Phe, 0.724; Cit, Tyr, Orn, Leu, 0.724; Cit, Tyr, Lys, Leu, 0.724; Cit, Tyr, Leu, Trp, 0.724; Cit, Met, Lys, Ile, 0.724; Cit, Orn, Lys, Ile, 0.724; Pro, Tyr, Val, Met, 0.724; Pro, Tyr, Ile, Trp, 0.724; Tyr, Orn, Lys, Ile, 0.724; Ser, Asn, His, Val, 0.724; Ser, Asn, Ile, Leu, 0.724; Ser, Gln, Thr, Leu, 0.724; Ser, His, Tyr, Ile, 0.724; Asn, Gln, Cit, Leu, 0.724; Asn, Ala, Tyr, Val, 0.724; Asn, Cit, Tyr, Val, 0.724; Asn, Arg, Pro, Leu, 0.724; Asn, Arg, Val, Ile, 0.724; Asn, Tyr, Val, Phe, 0.724; Gly, Gln, His, Pro, 0.724; Gly, Ile, Leu, Phe, 0.724; Gln, His, Cit, Lys, 0.724; Gln, His, Arg, Pro, 0.724; Gln, His, Pro, Met, 0.724; Gln, His, Met, Lys, 0.724; Gln, His, Lys, Phe, 0.724; Gln, His, Leu, Trp, 0.724; Gln, Ala, Pro, Ile, 0.724; His, Ala, Arg, Ile, 0.724; His, Cit, Orn, Ile, 0.724; His, Arg, Ile, Trp, 0.724; Cit, Arg, Ile, Phe, 0.724; Arg, Orn, Leu, Phe, 0.724; Tyr, Met, Leu, Trp, 0.724; Val, Lys, Leu, Phe, 0.724; Ile, Leu, Phe, Trp, 0.724; Ser, Asn, Ala, Leu, 0.723; Ser, Gln, His, Pro, 0.723; Ser, Gln, Ala, Ile, 0.723; Asn, His, Ala, Val, 0.723; Asn, His, Orn, Leu, 0.723; Asn, Thr, Leu, Phe, 0.723; Asn, Ala, Arg, Ile, 0.723; Asn, Pro, Ile, Trp, 0.723; Asn, Met, Ile, Trp, 0.723; Gly, Tyr, Val, Met, 0.723; Gly, Tyr, Ile, Trp, 0.723; Gly, Met, Lys, Ile, 0.723; Gln, Cit, Leu, Trp, 0.723; Gln, Pro, Tyr, Val, 0.723; Gln, Pro, Met, Leu, 0.723; Thr, Pro, Tyr, Ile, 0.723; Ala, Tyr, Met, Leu, 0.723; Ala, Met, Lys, Ile, 0.723; Arg, Tyr, Met, Lys, 0.723; Pro, Tyr, Met, Leu, 0.723; Pro, Ile, Leu, Phe, 0.723; Met, Orn, Lys, Ile, 0.723; Asn, Gln, Tyr, Lys, 0.723; Asn, His, Val, Orn, 0.723; Gly, Gln, His, Lys, 0.723; Gly, Lys, Leu, Phe, 0.723; Gln, His, Thr, Pro, 0.723; Gln, His, Thr, Lys, 0.723; Gln, His, Arg, Leu, 0.723; Gln, His, Val, Orn, 0.723; Gln, Arg, Pro, Lys, 0.723; His, Ala, Tyr, Ile, 0.723; His, Cit, Val, Lys, 0.723; His, Pro, Tyr, Ile, 0.723; Thr, Tyr, Met, Leu, 0.723; Thr, Lys, Ile, Phe, 0.723; Ala, Cit, Lys, Ile, 0.723; Arg, Tyr, Met, Leu, 0.723; Ser, Asn, Leu, Phe, 0.722; Ser, Gln, Tyr, Val, 0.722; Ser, His, Met, Ile, 0.722; Ser, Thr, Lys, Ile, 0.722; Asn, Gly, His, Leu, 0.722; Asn, Ala, Arg, Leu, 0.722; Asn, Ala, Orn, Ile, 0.722; Gly, Arg, Tyr, Val, 0.722; Gln, His, Lys, Trp, 0.722; Gln, Thr, Pro, Ile, 0.722; Gln, Cit, Tyr, Val, 0.722; Gln, Met, Ile, Phe, 0.722; Thr, Ala, Cit, Ile, 0.722; Thr, Cit, Pro, Ile, 0.722; Thr, Ile, Leu, Phe, 0.722; Ala, Arg, Tyr, Leu, 0.722; Cit, Pro, Tyr, Leu, 0.722; Cit, Val, Ile, Phe, 0.722; Ser, Gln, Val, Leu, 0.721; Ser, Gln, Met, Leu, 0.721; Ser, Cit, Lys, Ile, 0.721; Asn, Gly, Arg, Leu, 0.721; Asn, Pro, Lys, Leu, 0.721; Asn, Orn, Ile, Trp, 0.721; Gly, Cit, Lys, Ile, 0.721; Gln, His, Met, Leu, 0.721; Gln, Ala, Cit, Leu, 0.721; Gln, Arg, Tyr, Val, 0.721; Gln, Val, Met, Lys, 0.721; His, Tyr, Orn, Ile, 0.721; His, Lys, Leu, Phe, 0.721; Ala, Cit, Tyr, Leu, 0.721; Arg, Tyr, Val, Phe, 0.721; Tyr, Val, Met, Lys, 0.721; Tyr, Val, Lys, Ile, 0.721; Val, Ile, Phe, Trp, 0.721; Met, Lys, Ile, Leu, 0.721; Orn, Ile, Leu, Phe, 0.721; Asn, Gly, Pro, Leu, 0.721; Asn, Gly, Met, Leu, 0.721; Asn, His, Thr, Val, 0.721; Asn, His, Ala, Leu, 0.721; Asn, His, Cit, Val, 0.721; Asn, His, Cit, Leu, 0.721; Asn, His, Pro, Leu, 0.721; Asn, Thr, Met, Ile, 0.721; Asn, Thr, Ile, Trp, 0.721; Asn, Arg, Ile, Trp, 0.721; Asn, Val, Ile, Phe, 0.721; Asn, Met, Orn, Leu, 0.721; Gly, His, Tyr, Ile, 0.721; Gly, Cit, Pro, Ile, 0.721; Gln, His, Ala, Val, 0.721; Gln, His, Pro, Orn, 0.721; Gln, Pro, Val, Leu, 0.721; His, Cit, Arg, Ile, 0.721; His, Lys, Ile, Trp, 0.721; Thr, Arg, Tyr, Leu, 0.721; Ala, Met, Ile, Leu, 0.721; Cit, Pro, Tyr, Val, 0.721; Cit, Lys, Ile, Leu, 0.721; Tyr, Val, Met, Trp, 0.721; Tyr, Lys, Ile, Trp, 0.721; Met, Lys, Ile, Trp, 0.721; Ser, Asn, Gly, Leu, 0.72; Ser, Asn, Ala, Ile, 0.72; Ser, Asn, Met, Leu, 0.72; Ser, Gln, Cit, Leu, 0.72; Ser, Arg, Tyr, Leu, 0.72; Ser, Tyr, Met, Leu, 0.72; Ser, Tyr, Orn, Ile, 0.72; Asn, Gly, Thr, Ile, 0.72; Asn, Gly, Ile, Phe, 0.72; Asn, Ala, Leu, Phe, 0.72; Asn, Cit, Orn, Leu, 0.72; Asn, Cit, Leu, Phe, 0.72; Asn, Pro, Orn, Leu, 0.72; Asn, Val, Orn, Leu, 0.72; Asn, Met, Ile, Phe, 0.72; Asn, Leu, Phe, Trp, 0.72; Gly, His, Arg, Ile, 0.72; Gly, Ala, Cit, Ile, 0.72; Gly, Cit, Tyr, Leu, 0.72; Gly, Cit, Val, Ile, 0.72; Gly, Cit, Ile, Leu, 0.72; Gly, Cit, Ile, Phe, 0.72; Gly, Tyr, Val, Ile, 0.72; Gln, Thr, Pro, Leu, 0.72; Gln, Thr, Val, Leu, 0.72; Gln, Ala, Tyr, Val, 0.72; Gln, Ala, Leu, Phe, 0.72; Gln, Cit, Arg, Leu, 0.72; Gln, Pro, Tyr, Lys, 0.72; Gln, Val, Leu, Trp, 0.72; His, Cit, Ile, Trp, 0.72; His, Arg, Tyr, Val, 0.72; His, Arg, Val, Lys, 0.72; His, Tyr, Val, Ile, 0.72; His, Met, Ile, Leu, 0.72; Thr, Tyr, Val, Ile, 0.72; Thr, Tyr, Lys, Ile, 0.72; Ala, Cit, Pro, Ile, 0.72; Ala, Cit, Orn, Ile, 0.72; Ala, Tyr, Val, Ile, 0.72; Cit, Arg, Pro, Ile, 0.72; Cit, Tyr, Val, Met, 0.72; Cit, Met, Ile, Phe, 0.72; Cit, Ile, Leu, Trp, 0.72; Arg, Val, Lys, Phe, 0.72 [3. Four-variable formula including amino acids]
Gln, His, Tyr, Ile, 0.765; Gln, His, Ile, Phe, 0.763; Gln, Tyr, Ile, Phe, 0.761; Asn, Gln, His, Ile, 0.76; Gln, Arg, Lys, Ile, 0.759; Asn, Arg, Lys, Ile, 0.757; His, Tyr, Ile, Phe, 0.755; Gln, His, Met, Ile, 0.754; Asn, Cit, Lys, Ile, 0.753; Gln, His, Arg, Ile, 0.753; Gln, Tyr, Leu, Phe, 0.753; Asn, Gln, Lys, Ile, 0.752; Gln, His, Val, Ile, 0.752; Gly, Gln, Tyr, Ile, 0.752; Gln, His, Pro, Ile, 0.752; Gln, His, Ile, Leu, 0.752; Gln, Tyr, Leu, Trp, 0.752; Asn, Gln, Lys, Leu, 0.751; Gly, Gln, Tyr, Leu, 0.751; Gln, His, Ala, Ile, 0.751; Gln, His, Ile, Trp, 0.75; Thr, Tyr, Leu, Phe, 0.75; Asn, Thr, Lys, Ile, 0.749; Gly, Gln, His, Ile, 0.749; Gln, Cit, Tyr, Ile, 0.749; Gln, Tyr, Ile, Leu, 0.749; Gln, Tyr, Lys, Leu, 0.749; Gln, Ile, Leu, Phe, 0.749; His, Tyr, Met, Ile, 0.749; Arg, Lys, Ile, Phe, 0.749; Asn, Met, Lys, Ile, 0.748; Gln, His, Tyr, Leu, 0.748; Gln, Cit, Orn, Ile, 0.748; Lys, Ile, Phe, 0.748; Asn, Cit, Tyr, Ile, 0.747; Gln, Val, Lys, Ile, 0.747; Gln, Lys, Ile, Leu, 0.747; Tyr, Lys, Ile, 0.747; Asn, His, Lys, Ile, 0.747; Asn, His, Ile, Phe, 0.747; Asn, Lys, Ile, Leu, 0.747; Tyr, Lys, Ile, 0.747; Ser, Gln, Tyr, Ile, 0.746; Ser, Gln, Lys, Ile, 0.746; Asn, His, Tyr, Ile, 0.746; Asn, Tyr, Leu, Phe, 0.746; His, Lys, Ile, 0.746; Gln, Thr, Lys, Ile, 0.746; Gln, Ala, Cit, Ile, 0.746; Gln, Cit, Lys, Ile, 0.746; Gln, His, Ile, 0.745; Asn, Gly, Tyr, Leu, 0.745; Asn, Gln, Ile, Leu, 0.745; Asn, Gln, Leu, Phe, 0.745; Cit, Tyr, Ile, 0.745; Cit, Tyr, Val, Ile, 0.745; Cit, Tyr, Orn, Ile, 0.745; Cit, Tyr, Ile, Phe, 0.745; Met, Lys, Ile, 0.745; Gln, Orn, Lys, Ile, 0.745; Tyr, Met, Lys, Ile, 0.745; Tyr, Lys, Ile, Phe, 0.745; Asn, Gln, Tyr, Ile, 0.744; His, Met, Ile, 0.744; Gln, Cit, Pro, Ile, 0.744; His, C it, Tyr, Ile, 0.744; His, Arg, Tyr, Ile, 0.744; Asn, Orn, Lys, Ile, 0.743; Gly, Gln, Orn, Leu, 0.743; Arg, Tyr, Ile, 0.743; Gln, Tyr, Met, Ile, 0.743; Asn, Gln, Tyr, Leu, 0.743; Asn, His, Orn, Ile, 0.743; Gln, Cit, Ile, 0.743; Gly, Gln, Leu, Phe, 0.743; Gln, Cit, Arg, Ile, 0.743; Gln, Lys, Leu, Phe, 0.743; Tyr, Met, Ile, Phe, 0.743; Gln, Orn, Ile, 0.742; Asn, Gln, Orn, Leu, 0.742; Asn, Gln, Ile, Phe, 0.742; Asn, Lys, Ile, Phe, 0.742; Tyr, Met, Leu, 0.742; Cit, Pro, Tyr, Ile, 0.742; Arg, Pro, Tyr, Lys, 0.742; Ser, Gln, Tyr, Leu, 0.742; His, Orn, Leu, 0.742; Gln, Ala, Tyr, Leu, 0.742; Gln, Cit, Ile, Leu, 0.742; Gln, Cit, Ile, Phe, 0.742; Gln, Leu, Phe, 0.741; Asn, His, Ala, Ile, 0.741; Asn, His, Arg, Ile, 0.741; Asn, His, Val, Ile, 0.741; His, Tyr, Val, 0.741; Gln, Ala, Lys, Ile, 0.741; Gln, Ci t, Tyr, Leu, 0.741; Gln, Cit, Ile, Trp, 0.741; Gln, Pro, Lys, Ile, 0.741; Cit, Tyr, Met, Ile, 0.741; Lys, Ile, Leu, 0.741; Asn, Gln, Val, Lys, 0.74; Asn, Tyr, Met, Leu, 0.74; Asn, Tyr, Lys, Ile, 0.74; Cit, Tyr, Ile, Trp, 0.74; Ile, Leu, Phe, 0.74; Tyr, Leu, Phe, Trp, 0.74; Ser, Cit, Tyr, Ile, 0.74; Asn, Arg, Tyr, Ile, 0.74; Asn, Tyr, Lys, Leu, 0.74; Tyr, Val, Leu, 0.74; Cit, Tyr, Ile, Leu, 0.74; Tyr, Val, Ile, Phe, 0.74; Asn, Pro, Lys, Ile, 0.739; Asn, Tyr, Ile, Leu, 0.739; Val, Lys, Leu, 0.739; Asn, Lys, Leu, Phe, 0.739; Gln, His, Pro, Tyr, 0.739; Gln, His, Tyr, Lys, 0.739; Pro, Ile, Phe, 0.739; Gln, Tyr, Orn, Leu, 0.739; Gln, Tyr, Ile, Trp, 0.739; Gln, Val, Lys, Leu, 0.739; Arg, Ile, Phe, 0.739; Ser, Asn, Lys, Leu, 0.738; Ser, Arg, Lys, Ile, 0.738; Asn, Gly, Gln, Leu, 0.738; Thr, Tyr, Ile, 0.738; Gln, Thr, Ile, Leu, 0.738; Gln, Val, Leu, Phe, Gln, Lys, Leu, Trp, 0.738; Gln, Ile, Leu, Trp, 0.738; Asn, Tyr, Ile, Phe, 0.738; Gln, Thr, Cit, Ile, 0.738; Gln, Ala, Tyr, Ile, 0.738; Gln, Arg, Tyr, Leu, 0.738; Gln, Orn, Lys, Leu, 0.738; Gln, Orn, Ile, Phe, 0.738; Arg, Tyr, Orn, Lys, 0.738; Arg, Lys, Ile, Trp, 0.738; Tyr, Met, Ile, Leu, 0.738; Tyr, Met, Leu, Phe, 0.738; Asn, Gly, Lys, Leu, 0.737; Asn, His, Pro, Ile, 0.737; Asn, Arg, Tyr, Leu, 0.737; Asn, Orn, Lys, Leu, 0.737; Gln, Arg, Leu, Phe, 0.737; Gln, Tyr, Val, Ile, 0.737; Gln, Tyr, Val, Trp, 0.737; Gln, Orn, Leu, Trp, 0.737; Gln, Tyr, Orn, Ile, 0.737; Asn, Gln, Thr, Leu, 0.737; Asn, Gln, Cit, Ile, 0.737; Asn, His, Ile, Trp, 0.737; Gln, Ala, Ile, Leu, 0.737; Gln, Arg, Ile, Leu, 0.737; Gln, Val, Orn, Ile, 0.737; His, Lys, Ile, Phe, 0.737; Arg, Tyr, Ile, Phe, 0.737; Arg, Met, Lys, Ile, 0 Ser, Asn, His, Ile, 0.736; Ser, Gln, Orn, Leu, 0.736; Ser, Gln, Lys, Leu, 0.736; Asn, Gln, His, Tyr, 0.736; Asn, His, Thr, Ile, 0.736; Asn, His, Tyr, Val, 0.736; Asn, Tyr, Val, Lys, 0.736; Gly, Tyr, Met, Ile Gln, His, Tyr, Trp, 0.736; Gln, His, Leu, Phe, 0.736; Gln, Cit, Val, Ile, 0.736; Gln, Cit, Leu, Phe, 0.736; , 0.736; Arg, Ile, Leu, Phe, 0.736; Tyr, Orn, Ile, Phe, 0.736; Tyr, Ile, Phe, Trp, 0.736; Asn, Gln, Arg, Ile, 0.735; Asn, Ala, Lys, Ile, 0.735; Asn, Lys, Leu, Trp, 0.735; Gly, Arg, Lys, Ile, 0.735; Gln, Thr, Lys, Leu Gln, Ala, Lys, Leu, 0.735; Gln, Cit, Met, Ile, 0.735; Gln, Val, Ile, Phe, 0.735; Gln, Met, Lys, Leu, 0.735; Ser, Asn, Tyr, Leu, 0.735; Ser, Asn, Lys, Ile, 0.735; Asn, His, Cit, Ile, 0.735; Asn, His, Tyr, Leu , 0.735; Gly, Gln, Tyr, Val, 0.735; Gln, His, Tyr, Orn, 0. 735; Gln, Val, Orn, Leu, 0.735; Gln, Met, Ile, Leu, 0.735; His, Ile, Leu, Phe, 0.735; His, Ile, Phe, Trp, 0.735; Arg, Val, Lys, Ile, 0.735; Pro, Tyr, Met, Ile, 0.735; Tyr, Met, Ile, Trp, 0.735; Asn, Gln, Tyr, Val, 0.734; Gly, Gln, Pro, Ile, 0.734; Gly, Gln, Ile, Phe, 0.734; Gly, Arg, Tyr, Ile, 0.734; Gln, His, Pro, Leu, 0.734; Gln, Pro, Orn, Ile, 0.734; Gln, Met, Orn, Leu, 0.734; Ala, Tyr, Met, Ile, 0.734; Cit, Arg, Tyr, Lys, 0.734; Ser, Asn, Gln, Ile, 0.733; Ser, Asn, Gln, Leu, 0.733; Asn, Gln, Arg, Leu, 0.733; Asn, Ala, Tyr, Leu, 0.734; Asn, Tyr, Met, Ile, 0.733; Gly, Gln, Lys, Leu, 0.733; Gln, His, Cit, Tyr, 0.733; Gln, Thr, Arg, Ile, 0.733; Gln, Ala, Leu, Trp, 0.733; Gln, Cit, Lys, Leu, 0.733; Gln, Pro, Val, Ile, 0.733; Gln, Val, Met, Ile, 0.733; Ala, Tyr, Leu, Phe, 0.733; Cit, Ile, Leu, Phe, 0.7 33; Arg, Pro, Lys, Ile, 0.733; Pro, Tyr, Ile, Phe, 0.733; Tyr, Lys, Leu, Phe, 0.733; Lys, Ile, Leu, Phe, 0.733; Asn, Gln, Leu, Trp, 0.733; Asn, Thr, Lys, Leu, 0.733; Asn, Arg, Tyr, Val, 0.733; Asn, Tyr, Orn, Ile, 0.733; Gly, Gln, Ile, Leu, 0.733; Gly, Arg, Tyr, Lys, 0.733; Gln, His, Ala, Tyr, 0.733; Gln, His, Ala, Leu, 0.733; Gln, Val, Lys, Phe, 0.733; Gln, Val, Ile, Leu, 0.733; His, Cit, Ile, Phe, 0.733; Cit, Pro, Lys, Ile, 0.733; Ser, Asn, Tyr, Ile, 0.732; Ser, Gln, His, Tyr, 0.732; Ser, Gln, Arg, Ile, 0.732; Asn, Gly, Val, Lys, 0.732; Asn, Cit, Orn, Ile, 0.732; Asn, Cit, Ile, Phe, 0.732; Asn, Tyr, Val, Leu, 0.732; Asn, Tyr, Leu, Trp, 0.732; Asn, Val, Orn, Lys, 0.732; Asn, Met, Ile, Leu, 0.732; Gln, His, Ala, Lys, 0.732; Gln, Pro, Ile, Leu, 0.732; Gln, Ile, Phe, Trp, 0.732; Cit, Lys, Ile, Phe, 0.73 2; Arg, Tyr, Val, Ile, 0.732; Ser, Asn, Val, Lys, 0.731; Asn, Gly, Tyr, Ile, 0.731; Asn, Gly, Ile, Leu, 0.731; Asn, Gln, Met, Leu, 0.731; Asn, Cit, Tyr, Leu, 0.731; Asn, Val, Lys, Phe, 0.731; Asn, Met, Lys, Leu, 0.731; Gln, His, Cit, Pro, 0.731; Gln, Ala, Met, Leu, 0.731; Gln, Arg, Ile, Phe, 0.731; His, Tyr, Leu, Phe, 0.731; Ala, Tyr, Ile, Phe, 0.731; Arg, Tyr, Met, Ile, 0.731; Arg, Tyr, Leu, Phe, 0.731; Ser, Gln, Cit, Ile, 0.731; Asn, Gln, Ala, Leu, 0.731; Asn, His, Lys, Leu, 0.731; Asn, Thr, Val, Lys, 0.731; Gln, His, Thr, Tyr, 0.731; Gln, Thr, Val, Ile, 0.731; Gln, Thr, Leu, Trp, 0.731; Gln, Arg, Orn, Leu, 0.731; Gln, Orn, Ile, Trp, 0.731; His, Ala, Ile, Phe, His, Val, Ile, Phe, 0.731; Thr, Tyr, Met, Ile, 0.731; Tyr, Val, Met, Ile, 0.731; Tyr, Orn, Leu, Phe, 0.731; Ser, His, Ile, Phe, 0.73; Asn, Gly, Tyr, Val, 0.73; A sn, Gln, Ala, Ile, 0.73; Asn, Pro, Tyr, Ile, 0.73; Asn, Tyr, Val, Met, 0.73; Asn, Tyr, Orn, Leu, 0.73; Gly, Gln, Val, Ile, 0.73; Gly, His, Ile, Phe, 0.73; Gly, Tyr, Met, Leu, 0.73; Gln, His, Pro, Phe, 0.73; Gln, Thr, Ala, Leu, 0.73; Gln, Arg, Ile, Trp, 0.73; Gln, Pro, Met, Ile, 0.73; Gln, Tyr, Val, Met, 0.73; His, Arg, Lys, Ile, 0.73; Arg, Tyr, Lys, Leu, 0.73; Ser, Gln, Val, Ile, 0.73; Ser, Gln, Ile, Leu, 0.73; Ser, Tyr, Ile, Phe, 0.73; Asn, Gln, Met, Ile, 0.73; Asn, Ala, Cit, Ile, 0.73; Asn, Ala, Tyr, Ile, 0.73; Asn, Cit, Val, Lys, 0.73; Asn, Val, Ile, Leu, 0.73; Gln, Ala, Orn, Leu, 0.73; Gln, Arg, Orn, Ile, 0.73; Gln, Tyr, Val, Lys, 0.73; His, Arg, Tyr, Lys, 0.73; Thr, Arg, Tyr, Ile, 0.73; Arg, Tyr, Orn, Leu, 0.73; Ser, Gln, His, Leu, 0.729; Ser, Gln, Thr, Ile, 0.729; Ser, Gln, Orn, Ile, 0.729; Ser, Gln, Leu, Trp, 0.729; Ser, Tyr, Met, Ile, 0.729; Asn, Gly, Cit, Ile, 0.729; Asn, Thr, Tyr, Leu, 0.729; Asn, Arg, Tyr, Lys, 0.729; Orn, Leu, Phe, 0.729; Gly, Gln, Thr, Ile, 0.729; Gly, Gln, Ala, Ile, 0.729; Gly, Gln, Met, Ile, 0.729; Ala, Val, Leu, 0.729; Gln, Ala, Orn, Ile, 0.729; Gln, Ala, Ile, Trp, 0.729; Gln, Arg, Val, Ile, 0.729;

His, Thr, Ile, Phe, 0.729; His, Tyr, Ile, Trp, 0.729; His, Met, Lys, Ile, 0.729; Ser, Gln, Pro, Ile, 0.728; Asn, His, Leu, Phe, 0.728; Asn, Thr, Ile, Leu, 0.728; Asn, Ala, Ile, Trp, 0.728; Asn, Cit, Val, Ile, 0.728; , Cit, Lys, Leu, 0.728; Asn, Arg, Lys, Leu, 0.728; Asn, Pro, Tyr, Leu, 0.728; Asn, Pro, Leu, Phe, 0.728; , Gln, His, Tyr, 0.728; Gly, Gln, Arg, Ile, 0.728; Gly, Gln, Ile, Trp, 0.728; Gly, Gln, Leu, Trp, 0.728; , His, Pro, Lys, 0.728; Gln, His, Tyr, Met, 0.728; Gln, Arg, Pro, Ile, 0.728; Gln, Tyr, Val, Phe, 0.728; , Pro, Ile, Phe, 0.728; Thr, Tyr, Val, Phe, 0.728; Arg, Pro, Tyr, Ile, 0.728; Arg, Tyr, Orn, Ile, 0.728; Arg, Tyr, Ile, Leu, 0.728; , Val, Met, Phe, 0.728; Tyr, Met, Orn, Ile, 0.728; Ser, Gly, Gln, Ile, 0.728; Ser, Gln, Ile, Trp, 0.728; , Arg, Ile, Leu, 0.728; Asn, Tyr, Val, Orn, 0.728; Asn, Val, Leu, Phe, 0.728; Gly, Gln, Ala, Leu, 0.728; Gly, Tyr, Leu, Phe, 0.728; Gln, His, Val, Lys, 0.728; Thr, Orn, Ile, 0.728; Gln, Met, Orn, Ile, 0.728; Gln, Met, Ile, Trp, 0.728; Gln, Met, Leu, Phe, 0.728; His, Arg, Met, Ile, 0.728; Tyr, Lys, Ile, 0.728; His, Met, Ile, Phe, 0.728; Arg, Tyr, Ile, Trp, 0.728; Ser, Asn, Tyr, Val, 0.727; Ser, Thr, Tyr, Ile, 0.727; Tyr, Leu, Phe, 0.727; Asn, Gln, His, Val, 0.727; Asn, Gln, His, Leu, 0.727; Asn, Thr, Cit, Ile, 0.727; Asn, Thr, Tyr, Ile, 0.727; Gln, His, Leu, 0.727; Gly, Gln, Met, Leu, 0.727; Gln, His, Orn, Lys, 0.727; Gln, Thr, Ala, Ile, 0.727; Pro, Lys, Leu, 0.727; Gln, Pro, Leu, Phe, 0.727; Gln, Tyr, Val, Orn, 0.727; His, Cit, Lys, Ile, 0.727; Ala, Cit, Arg, Ile, 0.727; Arg, Tyr, Lys, 0.727; Tyr, Met, Lys, Leu, 0.727; Ser, Asn, Orn, Leu, 0.726; Ser, Met, Lys, Ile, 0.726; Asn, Gly, Val, Leu, 0.726; Gln, His, Lys, 0.726; Asn, His, Pro, Val, 0.726; Asn, His, Val, Met, 0.726; Asn, Ala, Ile, Leu, 0.726; Asn, Arg, Val, Lys, 0.726; Asn, Pro, Tyr, Val, 0.726; Tyr, Ile, Trp, 0.726; Asn, Val, Lys, Trp, 0.726; Gly, Gln, Thr, Leu, 0.726; Gly, Gln, Val, Lys, 0.726; Cit, Orn, Leu, 0.726; Gln, Met, Leu, Trp, 0.726; Pro, Tyr, Leu, Phe, 0.726; Tyr, Val, Ile, Trp, 0.726; Tyr, Orn, Ile, Trp, 0.726; Lys, Ile, Phe, 0.726; Met, Lys, Ile, Phe, 0.726; Orn, Lys, Ile, Phe, 0.726; Ser, Gly, Gln, Leu, 0.726; Ser, Gln, Ala, Leu, 0.726; Gln, Met, Ile, 0.726; Asn, Gly, Orn, Leu, 0.726; Asn, Gly, Leu, Phe, 0.726; Asn, Gly, Leu, Trp, 0.726; Met, Leu, Phe, 0.726; Gln, His, Thr, Leu, 0.726; Gln, Arg, Val, Lys, 0.726; Gln, Pro, Orn, Leu, 0.726; Arg, Tyr, Ile, 0.726; Arg, Tyr, Lys, Phe, 0.726; Tyr, Val, Met, Leu, 0.726; Tyr, Val, Leu, Phe, 0.726; Ser, Gln, Pro, Leu, 0.725; Gly, Cit, Leu, 0.725; Asn, Gln, Pro, Leu, 0.725; Asn, C it, Arg, Ile, 0.725; Asn, Cit, Pro, Ile, 0.725; Gly, Tyr, Orn, Ile, 0.725; Gln, Thr, Tyr, Val, 0.725; Ala, Arg, Ile, 0.725; Gln, Ala, Arg, Leu, 0.725; Gln, Ala, Val, Ile, 0.725; Gln, Arg, Lys, Leu, 0.725; Pro, Leu, Trp, 0.725; Gln, Val, Lys, Trp, 0.725; His, Thr, Tyr, Ile, 0.725; His, Arg, Orn, Ile, 0.725; Tyr, Val, Orn, 0.725; Cit, Lys, Ile, Trp, 0.725; Arg, Tyr, Leu, Trp, 0.725; Arg, Val, Orn, Lys, 0.725; Val, Met, Lys, Ile, 0.725; Asn, Gly, His, Val, 0.724; Asn, Gly, Thr, Leu, 0.724; Asn, Gln, His, Pro, 0.724; Asn, Ala, Lys, Leu, 0.724; Cit, Met, Ile, 0.724; Asn, Arg, Orn, Leu, 0.724; Asn, Pro, Ile, Leu, 0.724; Gly, Gln, Pro, Leu, 0.724; Arg, Met, Ile, 0.724; Gln, Val, Orn, Lys, 0.724; Thr, Tyr, Ile, Trp, 0.724; Ala, Ile, Leu, Phe, 0.724; Cit, Tyr, Orn, Leu, 0.724; Tyr, Lys, Leu, 0.724; Cit, Tyr, Leu, Trp, 0.724; Cit, Me t, Lys, Ile, 0.724; Cit, Orn, Lys, Ile, 0.724; Pro, Tyr, Val, Met, 0.724; Pro, Tyr, Ile, Trp, 0.724; Tyr, Orn, Lys, Ile, 0.724; Asn, His, Val, 0.724; Ser, Asn, Ile, Leu, 0.724; Ser, Gln, Thr, Leu, 0.724; Ser, His, Tyr, Ile, 0.724; Asn, Gln, Cit, Leu, 0.724; Ala, Tyr, Val, 0.724; Asn, Cit, Tyr, Val, 0.724; Asn, Arg, Pro, Leu, 0.724; Asn, Arg, Val, Ile, 0.724; Gln, His, Pro, 0.724; Gly, Ile, Leu, Phe, 0.724; Gln, His, Cit, Lys, 0.724; Gln, His, Arg, Pro, 0.724; His, Met, Lys, 0.724; Gln, His, Lys, Phe, 0.724; Gln, His, Leu, Trp, 0.724; Gln, Ala, Pro, Ile, 0.724; Cit, Orn, Ile, 0.724; His, Arg, Ile, Trp, 0.724; Cit, Arg, Ile, Phe, 0.724; Arg, Orn, Leu, Phe, 0.724; Tyr, Met, Leu, Trp, 0.724; Lys, Leu, Phe, 0.724; Ile, Leu, Phe, Trp, 0.724; Ser, Asn, Ala, Leu, 0.723; Ser, Gln, His, Pro, 0.723; Ser, Gln, Ala, Ile, 0.723; His, Ala, Val, 0.723; Asn, His, Orn, Leu, 0.723; Asn, Thr Asn, Pro, Ile, Trp, 0.723; Asn, Met, Ile, Trp, 0.723; Gly, Tyr, Val, Met, 0.723; Gly, Tyr , Ile, Trp, 0.723; Gly, Met, Lys, Ile, 0.723; Gln, Cit, Leu, Trp, 0.723; Gln, Pro, Tyr, Val, 0.723; Ala, Tyr, Met, Leu, 0.723; Ala, Met, Lys, Ile, 0.723; Arg, Tyr, Met, Lys, 0.723; Pro, Tyr, Met, Leu, 0.723; Met, Orn, Lys, Ile, 0.723; Asn, Gln, Tyr, Lys, 0.723; Asn, His, Val, Orn, 0.723; Gly, Gln, His, Lys, 0.723; Gln, His, Thr, Pro, 0.723; Gln, His, Thr, Lys, 0.723; Gln, His, Arg, Leu, 0.723; Gln, His, Val, Orn, 0.723; His, Ala, Tyr, Ile, 0.723; His, Cit, Val, Lys, 0.723; His, Pro, Tyr, Ile, 0.723; Thr, Tyr, Met, Leu, 0.723; Ala, Cit, Lys, Ile, 0.723; Arg, Tyr, Met, Leu, 0.723; Ser, Asn, Leu, Phe, 0.722; Ser, Gln, Tyr, Val, 0.722; , Met, Ile, 0.722; Ser, Thr, Lys, Ile, 0.722; Asn, Gly, His, Leu, 0.722; Asn, Ala, Arg, Leu, 0.722; Asn, Ala, Orn, Ile, 0.722; Gly, Arg, Tyr, Val, 0.722; Pro, Ile, 0.722; Gln, Cit, Tyr, Val, 0.722; Gln, Met, Ile, Phe, 0.722; Thr, Ala, Cit, Ile, 0.722; Thr, Cit, Pro, Ile, 0.722; Leu, Phe, 0.722; Ala, Arg, Tyr, Leu, 0.722; Cit, Pro, Tyr, Leu, 0.722; Cit, Val, Ile, Phe, 0.722; Ser, Gln, Val, Leu, 0.721; Met, Leu, 0.721; Ser, Cit, Lys, Ile, 0.721; Asn, Gly, Arg, Leu, 0.721; Asn, Pro, Lys, Leu, 0.721; Lys, Ile, 0.721; Gln, His, Met, Leu, 0.721; Gln, Ala, Cit, Leu, 0.721; Gln, Arg, Tyr, Val, 0.721; Orn, Ile, 0.721; His, Lys, Leu, Phe, 0.721; Ala, Cit, Tyr, Leu, 0.721; Arg, Tyr, Val, Phe, 0.721; Tyr, Val, Met, Lys, 0.721; Lys, Ile, 0.721; Val, Ile, Phe, Trp, 0.721; Met, Lys, Ile, Leu, 0.721; Orn, Ile, Leu, Phe, 0.721; Asn, Gly, Pro, Leu, 0.721; Met, Leu, 0.721; Asn, His, Thr, Val, 0.721; Asn, His, Ala, Leu, 0.721; Asn, His, Cit, Val, 0.721; Asn, His, Cit, Leu, 0.721; Asn, His, Pro, Leu, 0.721; Asn, Thr, Met, Ile, 0.721; Ile, Trp, 0.721; Asn, Arg, Ile, Trp, 0.721; Asn, Val, Ile, Phe, 0.721; Asn, Met, Orn, Leu, 0.721; Pro, Ile, 0.721; Gln, His, Ala, Val, 0.721; Gln, His, Pro, Orn, 0.721; Gln, Pro, Val, Leu, 0.721; His, Cit, Arg, Ile, 0.721; Ile, Trp, 0.721; Thr, Arg, Tyr, Leu, 0.721; Ala, Met, Ile, Leu, 0.721; Cit, Pro, Tyr, Val, 0.721; Cit, Lys, Ile, Leu, 0.721; Met, Trp, 0.721; Tyr, Lys, Ile, Trp, 0.721; Met, Lys, Ile, Trp, 0.721; Ser, Asn, Gly, Leu, 0.72; Ser, Asn, Ala, Ile, 0.72; Met, Leu, 0.72; Ser, Gln, Cit, Leu, 0.72; Ser, Arg, Tyr, Leu, 0.72; Ser, Tyr, Met, Leu, 0.72; Ser, Tyr, Orn, Ile, 0.72; Thr, Ile, 0.72; Asn, Gly, Ile, Phe, 0.72; Asn, Ala, Leu, Phe, 0.72; Asn, Cit, Orn, Leu, 0.72; Asn, Cit, Leu, Phe, 0.72; Orn, Leu, 0.72; Asn, Val, Orn, Leu, 0.72; Asn, Met, Ile, Phe, 0.72; Asn, Leu, Phe, Trp, 0.72; Gly, His, Arg, Ile, 0.72; Gly, Ala, Cit, Ile, 0.72; Gly, Cit, Tyr, Leu, 0.72; Gly, Cit, Ile, Leu, 0.72; Gly, Cit, Ile, Phe, 0.72; Gly, Tyr, Val, Ile, 0.72; Gln, Thr, Pro, Leu, 0.72; Gln, Ala, Tyr, Val, 0.72; Gln, Ala, Leu, Phe, 0.72; Gln, Cit, Arg, Leu, 0.72; Gln, Pro, Tyr, Lys, 0.72; His, Cit, Ile, Trp, 0.72; His, Arg, Tyr, Val, 0.72; His, Arg, Val, Lys, 0.72; His, Tyr, Val, Ile, 0.72; His, Met, Ile, Leu, 0.72; Thr, Tyr, Val, Ile, 0.72; Thr, Tyr, Lys, Ile, 0.72; Ala, Cit, Pro, Ile, 0.72; Ala, Cit, Orn, Ile, 0.72; Ala, Tyr, Val, Ile, 0.72; Cit, Arg, Pro, Ile, 0.72; Cit, Tyr, Val, Met, 0.72; Cit, Met, Ile, Phe, 0.72; Cit, Ile, Leu, Trp, 0.72;
［４．アミノ酸を含む５変数の式］
Arg, Tyr, Lys, Ile, Phe, 0.776; Gln, His, Tyr, Ile, Phe, 0.774; Gln, Tyr, Lys, Ile, Phe, 0.771; Asn, Arg, Tyr, Lys, Ile, 0.77; Gln, His, Cit, Ile, Phe, 0.77; Asn, Gln, His, Ile, Phe, 0.769; Gln, His, Arg, Tyr, Ile, 0.769; Ser, Gln, Tyr, Ile, Phe, 0.768; Asn, Gln, Tyr, Leu, Phe, 0.768; Gln, His, Tyr, Ile, Trp, 0.768; Gln, Tyr, Ile, Leu, Phe, 0.768; Asn, Gln, His, Cit, Ile, 0.767; Asn, Gln, His, Tyr, Ile, 0.766; Gln, His, Cit, Pro, Ile, 0.766; Gln, His, Cit, Orn, Ile, 0.766; Asn, Gln, His, Ala, Ile, 0.765; Gly, Gln, Tyr, Leu, Phe, 0.765; Gln, His, Tyr, Val, Ile, 0.765; Gln, His, Tyr, Orn, Ile, 0.765; Gln, Arg, Lys, Ile, Phe, 0.765; Gln, His, Arg, Ile, Phe, 0.764; Gln, His, Ile, Leu, Phe, 0.764; Asn, Gly, Gln, Tyr, Ile, 0.764; Asn, His, Cit, Tyr, Ile, 0.764; Gly, Arg, Tyr, Lys, Ile, 0.764; Gln, His, Tyr, Met, Ile, 0.764; Gln, Tyr, Met, Ile, Phe, 0.764; Gly, Gln, Tyr, Leu, Trp, 0.763; Gln, His, Cit, Tyr, Ile, 0.763; Gln, His, Tyr, Ile, Leu, 0.763; Gln, His, Ile, Phe, Trp, 0.763; Gln, Arg, Lys, Ile, Trp, 0.763; Asn, Gly, Cit, Tyr, Ile, 0.763; Asn, Gln, Tyr, Ile, Phe, 0.763; Gly, Gln, Tyr, Ile, Phe, 0.763; Gln, His, Ala, Tyr, Ile, 0.763; Gln, His, Pro, Tyr, Ile, 0.763; Gln, Tyr, Leu, Phe, Trp, 0.763; Arg, Tyr, Met, Lys, Ile, 0.763; Asn, Gln, His, Pro, Ile, 0.762; Asn, Gln, His, Orn, Ile, 0.762; Gln, His, Ala, Cit, Ile, 0.762; Gln, Thr, Tyr, Ile, Phe, 0.762; Gln, Ala, Tyr, Ile, Phe, 0.762; Gln, Tyr, Ile, Phe, Trp, 0.762; Ser, Gln, His, Tyr, Ile, 0.761; Asn, Gly, Cit, Lys, Ile, 0.761; Asn, Gln, His, Arg, Ile, 0.761; Asn, Cit, Tyr, Lys, Ile, 0.761; Asn, Arg, Lys, Ile, Phe, 0.761; Gly, Gln, His, Tyr, Leu, 0.761; Gln, Tyr, Val, Ile, Phe, 0.761; Ser, Arg, Tyr, Lys, Ile, 0.761; Asn, Gly, Gln, Lys, Ile, 0.761; Asn, Gln, His, Val, Ile, 0.761; Asn, Gln, Arg, Lys, Ile, 0.761; Gly, Gln, Arg, Lys, Ile, 0.761; Gln, His, Thr, Tyr, Ile, 0.761; Gln, His, Val, Ile, Phe, 0.761; Gln, Pro, Tyr, Ile, Phe, 0.761; His, Arg, Tyr, Ile, Phe, 0.761; Asn, Gln, His, Ile, Leu, 0.76; Asn, Arg, Pro, Tyr, Lys, 0.76; Asn, Arg, Orn, Lys, Ile, 0.76; Gly, Gln, Tyr, Lys, Ile, 0.76; Gln, His, Cit, Ile, Trp, 0.76; Gln, His, Tyr, Leu, Phe, 0.76; Gln, Arg, Orn, Lys, Ile, 0.76; Gln, Tyr, Orn, Ile, Phe, 0.76; His, Tyr, Met, Lys, Ile, 0.76; Asn, Gly, Gln, Lys, Leu, 0.759; Asn, Gly, Arg, Lys, Ile, 0.759; Asn, Gln, His, Met, Ile, 0.759; Asn, Gln, Lys, Ile, Phe, 0.759; Gln, His, Cit, Arg, Ile, 0.759; Gln, His, Cit, Ile, Leu, 0.759; Gln, His, Met, Ile, Phe, 0.759; Tyr, Met, Lys, Ile, Phe, 0.759; Ser, Asn, Arg, Lys, Ile, 0.759; Asn, Gln, His, Tyr, Leu, 0.759; Asn, Gln, Lys, Leu, Phe, 0.759; Gln, His, Ala, Ile, Trp, 0.759; Gln, His, Cit, Val, Ile, 0.759; Gln, His, Tyr, Lys, Leu, 0.759; Gln, Cit, Arg, Lys, Ile, 0.759; Gln, Arg, Val, Lys, Ile, 0.759; Ser, Gly, Gln, Tyr, Ile, 0.758; Asn, Gly, Gln, His, Ile, 0.758; Asn, Gln, His, Lys, Ile, 0.758; Asn, Cit, Pro, Lys, Ile, 0.758; Asn, Tyr, Met, Lys, Ile, 0.758; Gly, Gln, His, Ile, Phe, 0.758; Gly, Gln, Tyr, Ile, Leu, 0.758; Gln, His, Ala, Met, Ile, 0.758; Gln, His, Cit, Met, Ile, 0.758; Gln, Tyr, Orn, Leu, Phe, 0.758; Gln, Tyr, Lys, Leu, Phe, 0.758; His, Arg, Tyr, Lys, Ile, 0.758; Cit, Tyr, Lys, Ile, Trp, 0.758; Ser, His, Tyr, Ile, Phe, 0.757; Gln, His, Ala, Ile, Phe, 0.757; Arg, Pro, Tyr, Lys, Ile, 0.757; Ser, Gln, Arg, Lys, Ile, 0.757; Asn, His, Lys, Ile, Phe, 0.757; Gln, His, Tyr, Leu, Trp, 0.757; Gln, His, Val, Met, Ile, 0.757; Arg, Tyr, Lys, Ile, Trp, 0.757; Asn, Gly, Gln, Tyr, Leu, 0.757; Asn, Gln, His, Ile, Trp, 0.757; Asn, His, Cit, Lys, Ile, 0.757; Asn, His, Arg, Tyr, Ile, 0.757; Asn, Thr, Tyr, Leu, Phe, 0.757; Asn, Cit, Arg, Lys, Ile, 0.757; Asn, Cit, Lys, Ile, Leu, 0.757; Asn, Arg, Lys, Ile, Leu, 0.757; Asn, Arg, Lys, Ile, Trp, 0.757; Gly, Gln, His, Cit, Ile, 0.757; Gly, Gln, Tyr, Met, Ile, 0.757; Gln, His, Thr, Cit, Ile, 0.757; Gln, His, Arg, Pro, Ile, 0.757; Gln, Thr, Arg, Lys, Ile, 0.757; Gln, Thr, Tyr, Leu, Phe, 0.757; Gln, Pro, Tyr, Leu, Phe, 0.757; Gln, Tyr, Ile, Leu, Trp, 0.757; Cit, Arg, Tyr, Lys, Ile, 0.757; Asn, Gln, Thr, Leu, Phe, 0.756; Asn, Gln, Val, Lys, Ile, 0.756; Asn, Cit, Tyr, Ile, Phe, 0.756; Asn, Cit, Orn, Lys, Ile, 0.756; Gln, His, Arg, Orn, Ile, 0.756; Gln, His, Orn, Ile, Phe, 0.756; Gln, Cit, Tyr, Ile, Phe, 0.756; Gln, Cit, Ile, Leu, Phe, 0.756; Gln, Tyr, Met, Lys, Ile, 0.756; Gln, Tyr, Met, Leu, Phe, 0.756; His, Tyr, Met, Ile, Phe, 0.756; Arg, Tyr, Orn, Lys, Ile, 0.756; Arg, Tyr, Ile, Leu, Phe, 0.756; Asn, Gln, His, Thr, Ile, 0.756; Asn, Gln, Cit, Lys, Ile, 0.756; Asn, Gln, Tyr, Lys, Leu, 0.756; Asn, Gln, Tyr, Ile, Leu, 0.756; Asn, Gln, Lys, Ile, Leu, 0.756; Asn, Tyr, Lys, Leu, Phe, 0.756; Asn, Lys, Ile, Leu, Phe, 0.756; Gly, Gln, Lys, Ile, Phe, 0.756; Gln, His, Lys, Ile, Phe, 0.756; Ser, Asn, Gln, His, Ile, 0.755; Asn, Thr, Arg, Lys, Ile, 0.755; Asn, Arg, Val, Lys, Ile, 0.755; Gly, Gln, Cit, Tyr, Ile, 0.755; Gly, Gln, Tyr, Lys, Leu, 0.755; Gln, His, Ala, Arg, Ile, 0.755; Gln, His, Tyr, Lys, Ile, 0.755; His, Thr, Tyr, Ile, Phe, 0.755; His, Tyr, Ile, Leu, Phe, 0.755; Thr, Arg, Tyr, Lys, Ile, 0.755; Arg, Tyr, Val, Lys, Ile, 0.755; Ser, Asn, Gln, Lys, Ile, 0.754; Ser, Gln, Tyr, Leu, Trp, 0.754; Asn, Gln, His, Orn, Leu, 0.754; Asn, Gln, Tyr, Lys, Ile, 0.754; Asn, Gln, Ile, Leu, Phe, 0.754; Asn, His, Tyr, Met, Ile, 0.754; Asn, His, Tyr, Ile, Leu, 0.754; Asn, Thr, Lys, Ile, Leu, 0.754; Asn, Cit, Tyr, Orn, Ile, 0.754; Gln, His, Thr, Ile, Phe, 0.754; Gln, His, Arg, Val, Ile, 0.754; Gln, His, Arg, Lys, Ile, 0.754; Gln, His, Tyr, Val, Trp, 0.754; Gln, His, Met, Ile, Leu, 0.754; His, Ala, Tyr, Ile, Phe, 0.754; His, Cit, Tyr, Met, Ile, 0.754; His, Tyr, Met, Ile, Trp, 0.754; Ser, Gln, His, Ile, Phe, 0.754; Ser, Gln, Tyr, Lys, Ile, 0.754; Asn, Gln, Thr, Lys, Leu, 0.754; Asn, Gln, Ala, Lys, Ile, 0.754; Asn, Gln, Tyr, Leu, Trp, 0.754; Asn, Gln, Orn, Lys, Ile, 0.754; Asn, Gln, Orn, Lys, Leu, 0.754; Asn, His, Tyr, Ile, Phe, 0.754; Asn, Thr, Cit, Lys, Ile, 0.754; Asn, Tyr, Met, Leu, Phe, 0.754; Asn, Tyr, Ile, Leu, Phe, 0.754; Gly, Gln, His, Tyr, Ile, 0.754; Gly, Gln, Ala, Tyr, Ile, 0.754; Gly, Gln, Tyr, Ile, Trp, 0.754; Gln, His, Ala, Tyr, Leu, 0.754; Gln, His, Met, Ile, Trp, 0.754; Gln, Cit, Tyr, Orn, Ile, 0.754; Gln, Cit, Lys, Ile, Phe, 0.754; Gln, Arg, Lys, Ile, Leu, 0.754; His, Pro, Tyr, Ile, Phe, 0.754; Arg, Tyr, Lys, Ile, Leu, 0.754; Asn, Gln, Lys, Ile, Trp, 0.753; Asn, Cit, Val, Lys, Ile, 0.753; Asn, Arg, Tyr, Lys, Leu, 0.753; Asn, Arg, Met, Lys, Ile, 0.753; Gly, Gln, Cit, Tyr, Leu, 0.753; Gly, Gln, Arg, Tyr, Ile, 0.753; Gly, Gln, Pro, Tyr, Ile, 0.753; Gln, His, Pro, Ile, Phe, 0.753; Gln, Ala, Arg, Lys, Ile, 0.753; Gln, Cit, Pro, Orn, Ile, 0.753; Gln, Cit, Tyr, Leu, Phe, 0.753; Gln, Arg, Tyr, Lys, Ile, 0.753; Gln, Arg, Met, Lys, Ile, 0.753; Gln, Arg, Ile, Leu, Phe, 0.753; Gln, Tyr, Val, Leu, Phe, 0.753; Gln, Tyr, Orn, Leu, Trp, 0.753; Gln, Tyr, Lys, Ile, Trp, 0.753; Gln, Lys, Ile, Leu, Phe, 0.753; Gln, Lys, Ile, Leu, Trp, 0.753; His, Tyr, Lys, Ile, Phe, 0.753; Thr, Tyr, Ile, Leu, Phe, 0.753; Ala, Arg, Tyr, Lys, Ile, 0.753; Ser, Asn, Gln, Tyr, Ile, 0.752; Ser, Asn, His, Tyr, Ile, 0.752; Asn, Gly, Arg, Tyr, Ile, 0.752; Asn, His, Pro, Tyr, Ile, 0.752; Asn, Arg, Tyr, Leu, Phe, 0.752; Gly, Gln, Thr, Tyr, Ile, 0.752; Gln, His, Thr, Met, Ile, 0.752; Gln, His, Arg, Ile, Leu, 0.752; Gln, His, Arg, Ile, Trp, 0.752; Gln, His, Pro, Met, Ile, 0.752; Gln, His, Pro, Ile, Leu, 0.752; Gln, His, Tyr, Val, Leu, 0.752; Gln, Thr, Tyr, Ile, Leu, 0.752; His, Cit, Tyr, Ile, Phe, 0.752; Ala, Arg, Lys, Ile, Phe, 0.752; Arg, Orn, Lys, Ile, Phe, 0.752; Ser, Asn, Cit, Tyr, Ile, 0.752; Ser, Gln, His, Cit, Ile, 0.752; Ser, Gln, Tyr, Ile, Trp, 0.752; Ser, Gln, Tyr, Leu, Phe, 0.752; Asn, Gly, Gln, Orn, Leu, 0.752; Asn, Gly, His, Tyr, Ile, 0.752; Asn, Gly, Tyr, Leu, Phe, 0.752; Asn, His, Tyr, Lys, Ile, 0.752; Asn, His, Met, Ile, Phe, 0.752; Asn, Ala, Cit, Lys, Ile, 0.752; Asn, Cit, Tyr, Met, Ile, 0.752; Asn, Cit, Lys, Ile, Phe, 0.752; Gly, Gln, Ala, Cit, Ile, 0.752; Gly, Gln, Tyr, Orn, Ile, 0.752; Gly, His, Tyr, Ile, Phe, 0.752; Gly, Cit, Tyr, Val, Ile, 0.752; Gln, His, Ala, Pro, Ile, 0.752; Gln, His, Ala, Val, Ile, 0.752; Gln, His, Val, Ile, Leu, 0.752; Gln, His, Met, Orn, Ile, 0.752; Gln, Tyr, Val, Lys, Trp, 0.752; Gln, Val, Lys, Ile, Phe, 0.752; Gln, Orn, Ile, Leu, Phe, 0.752; Thr, Arg, Lys, Ile, Phe, 0.752; Cit, Tyr, Val, Orn, Ile, 0.752; Arg, Met, Lys, Ile, Phe, 0.752; Arg, Lys, Ile, Phe, Trp, 0.752; Ser, Gln, His, Arg, Ile, 0.751; Ser, His, Tyr, Met, Ile, 0.751; Asn, Gly, Ala, Tyr, Leu, 0.751; Asn, Gly, Cit, Tyr, Leu, 0.751; Gly, Gln, His, Ala, Ile, 0.751; Gly, Gln, Thr, Lys, Ile, 0.751; Gly, Gln, Ala, Tyr, Leu, 0.751; Gly, Gln, Cit, Lys, Ile, 0.751; Gly, Gln, Tyr, Orn, Leu, 0.751; Gly, Gln, Lys, Ile, Trp, 0.751; Gly, Cit, Tyr, Met, Ile, 0.751; Gln, His, Thr, Arg, Ile, 0.751; Gln, His, Arg, Met, Ile, 0.751; Gln, His, Pro, Tyr, Leu, 0.751; Gln, His, Tyr, Met, Leu, 0.751; Gln, Thr, Lys, Ile, Phe, 0.751; Gln, Cit, Lys, Ile, Trp, 0.751; Gln, Arg, Tyr, Ile, Phe, 0.751; Gln, Arg, Tyr, Leu, Phe, 0.751; Gln, Orn, Lys, Ile, Phe, 0.751; Gln, Ile, Leu, Phe, Trp, 0.751; Cit, Tyr, Ile, Leu, Phe, 0.751; Asn, Gln, His, Tyr, Val, 0.75; Asn, Gln, Cit, Tyr, Leu, 0.75; Asn, Gln, Cit, Orn, Ile, 0.75; Asn, Gln, Tyr, Met, Leu, 0.75; Asn, Thr, Val, Lys, Ile, 0.75; Asn, Arg, Pro, Lys, Ile, 0.75; Gly, Gln, His, Val, Ile, 0.75; Gly, Gln, Cit, Orn, Ile, 0.75; Gln, His, Pro, Val, Ile, 0.75; Gln, Tyr, Val, Ile, Leu, 0.75; Gln, Tyr, Lys, Leu, Trp, 0.75; His, Thr, Tyr, Met, Ile, 0.75; His, Tyr, Orn, Ile, Phe, 0.75; Ser, Gln, Lys, Ile, Trp, 0.75; Ser, Arg, Lys, Ile, Trp, 0.75; Asn, Gln, Thr, Lys, Ile, 0.75; Asn, Gln, Cit, Tyr, Ile, 0.75; Asn, Gln, Cit, Lys, Leu, 0.75; Asn, Gln, Lys, Leu, Trp, 0.75; Asn, His, Met, Lys, Ile, 0.75; Gly, Gln, His, Arg, Ile, 0.75; Gly, Gln, Met, Lys, Ile, 0.75; Gly, Gln, Orn, Lys, Ile, 0.75; Gln, His, Val, Ile, Trp, 0.75; Gln, Thr, Lys, Ile, Trp, 0.75; Gln, Tyr, Met, Ile, Leu, 0.75; Gln, Met, Lys, Ile, Phe, 0.75; His, Arg, Tyr, Met, Ile, 0.75; His, Arg, Lys, Ile, Phe, 0.75; His, Tyr, Ile, Phe, Trp, 0.75; Ser, Gln, Val, Lys, Ile, 0.75; Asn, Gly, Thr, Lys, Ile, 0.75; Asn, Gly, Tyr, Met, Leu, 0.75; Asn, Gln, Pro, Lys, Ile, 0.75; Asn, Gln, Val, Lys, Leu, 0.75; Asn, His, Val, Orn, Lys, 0.75; Asn, Thr, Met, Lys, Ile, 0.75; Asn, Cit, Met, Lys, Ile, 0.75; Gly, Gln, His, Met

, Ile, 0.75; Gly, Gln, His, Ile, Leu, 0.75; Gly, His, Tyr, Met, Ile, 0.75; Gln, His, Thr, Ala, Ile, 0.75; Gln, Ala, Tyr, Leu, Trp, 0.75; Arg, Val, Lys, Ile, Phe, 0.75; Tyr, Met, Ile, Leu, Phe, 0.75; Ser, Asn, Gln, Orn, Leu, 0.749; Ser, Gln, Lys, Ile, Phe, 0.749; Asn, Gly, Tyr, Lys, Leu, 0.749; Asn, Gln, Thr, Tyr, Leu, 0.749; Asn, Gln, Ala, Lys, Leu, 0.749; Asn, His, Thr, Ile, Phe, 0.749; Asn, His, Orn, Ile, Phe, 0.749; Asn, His, Lys, Ile, Leu, 0.749; Asn, His, Ile, Phe, Trp, 0.749; Asn, Cit, Arg, Tyr, Ile, 0.749; Asn, Cit, Tyr, Ile, Trp, 0.749; Asn, Pro, Tyr, Leu, Phe, 0.749; Asn, Orn, Lys, Ile, Leu, 0.749; Gln, His, Thr, Ile, Leu, 0.749; Gln, His, Ala, Ile, Leu, 0.749; Gln, His, Pro, Ile, Trp, 0.749; Gln, His, Tyr, Orn, Leu, 0.749; Gln, His, Orn, Lys, Ile, 0.749; Gln, His, Orn, Ile, Trp, 0.749; Gln, His, Ile, Leu, Trp, 0.749; Gln, Ala, Cit, Tyr, Ile, 0.749; Gln, Ala, Tyr, Lys, Leu, 0.749; Gln, Tyr, Lys, Ile, Leu, 0.749; Gln, Val, Lys, Ile, Leu, 0.749; Gln, Val, Lys, Ile, Trp, 0.749; His, Cit, Tyr, Lys, Ile, 0.749; His, Pro, Tyr, Met, Ile, 0.749; Cit, Tyr, Met, Orn, Ile, 0.749; Ser, Asn, Gln, Lys, Leu, 0.749; Ser, Arg, Lys, Ile, Phe, 0.749; Asn, Gly, Gln, Cit, Ile, 0.749; Asn, Gln, His, Pro, Tyr, 0.749; Asn, Gln, Arg, Tyr, Ile, 0.749; Asn, Gln, Tyr, Val, Ile, 0.749; Asn, Gln, Tyr, Orn, Leu, 0.749; Asn, Gln, Met, Lys, Ile, 0.749; Asn, His, Arg, Lys, Ile, 0.749; Asn, His, Arg, Ile, Phe, 0.749; Asn, Thr, Orn, Lys, Ile, 0.749; Asn, Ala, Arg, Lys, Ile, 0.749; Asn, Val, Lys, Ile, Leu, 0.749; Asn, Met, Lys, Ile, Leu, 0.749; Gly, Gln, His, Pro, Ile, 0.749; Gly, Gln, His, Lys, Ile, 0.749; Gly, Gln, Cit, Pro, Ile, 0.749; Gly, His, Arg, Tyr, Ile, 0.749; Gly, Cit, Tyr, Ile, Phe, 0.749; Gly, Cit, Tyr, Ile, Trp, 0.749; Gly, Arg, Lys, Ile, Phe, 0.749; Gln, His, Thr, Val, Ile, 0.749; Gln, His, Val, Orn, Ile, 0.749; Gln, His, Lys, Ile, Trp, 0.749; Gln, Thr, Cit, Tyr, Ile, 0.749; Gln, Cit, Pro, Tyr, Ile, 0.749; Gln, Cit, Tyr, Lys, Ile, 0.749; Gln, Pro, Tyr, Ile, Leu, 0.749; Gln, Tyr, Val, Ile, Trp, 0.749; Gln, Tyr, Orn, Ile, Leu, 0.749; Gln, Met, Lys, Ile, Trp, 0.749; His, Tyr, Met, Orn, Ile, 0.749; His, Tyr, Met, Ile, Leu, 0.749; Ala, Cit, Tyr, Lys, Ile, 0.749; Cit, Arg, Lys, Ile, Phe, 0.749; Cit, Pro, Tyr, Orn, Ile, 0.749; Ser, Asn, His, Lys, Ile, 0.748; Ser, Thr, Tyr, Leu, Phe, 0.748; Ser, Arg, Met, Lys, Ile, 0.748; Asn, Gly, Gln, Tyr, Val, 0.748; Asn, Gln, Val, Orn, Lys, 0.748; Asn, His, Tyr, Ile, Trp, 0.748; Asn, His, Tyr, Leu, Phe, 0.748; Asn, Cit, Tyr, Leu, Phe, 0.748; Asn, Cit, Lys, Ile, Trp, 0.748; Asn, Pro, Lys, Ile, Leu, 0.748; Asn, Tyr, Met, Ile, Leu, 0.748; Asn, Tyr, Lys, Ile, Phe, 0.748; Asn, Tyr, Lys, Leu, Trp, 0.748; Gly, Gln, Tyr, Val, Ile, 0.748; Gly, Gln, Tyr, Val, Leu, 0.748; Gly, Gln, Tyr, Val, Phe, 0.748; Gly, Gln, Tyr, Met, Leu, 0.748; Gly, Gln, Val, Lys, Ile, 0.748; Gln, His, Thr, Pro, Ile, 0.748; Gln, His, Cit, Lys, Ile, 0.748; Gln, His, Tyr, Val, Orn, 0.748; Gln, Thr, Lys, Leu, Phe, 0.748; Gln, Ala, Lys, Ile, Trp, 0.748; Gln, Cit, Arg, Orn, Ile, 0.748; Gln, Cit, Tyr, Lys, Leu, 0.748; Gln, Cit, Tyr, Ile, Trp, 0.748; Gln, Cit, Orn, Lys, Ile, 0.748; Gln, Cit, Orn, Ile, Phe, 0.748; Gln, Cit, Orn, Ile, Trp, 0.748; Gln, Arg, Tyr, Ile, Leu, 0.748; Gln, Pro, Tyr, Lys, Leu, 0.748; Gln, Pro, Tyr, Leu, Trp, 0.748; Gln, Tyr, Val, Lys, Ile, 0.748; Gln, Tyr, Val, Leu, Trp, 0.748; Gln, Tyr, Met, Ile, Trp, 0.748; Gln, Tyr, Met, Leu, Trp, 0.748; Gln, Orn, Lys, Ile, Trp, 0.748; Gln, Orn, Lys, Leu, Phe, 0.748; Gln, Lys, Ile, Phe, Trp, 0.748; His, Tyr, Val, Met, Ile, 0.748; Thr, Tyr, Lys, Ile, Phe, 0.748; Cit, Tyr, Met, Lys, Ile, 0.748; Cit, Tyr, Ile, Leu, Trp, 0.748; Arg, Tyr, Val, Lys, Trp, 0.748; Arg, Tyr, Lys, Leu, Trp, 0.748; Tyr, Lys, Ile, Leu, Phe, 0.748; Ser, Asn, Gln, Tyr, Leu, 0.747; Ser, Asn, Cit, Lys, Ile, 0.747; Ser, Asn, Arg, Tyr, Ile, 0.747; Ser, Gly, Gln, Lys, Ile, 0.747; Ser, Gln, Tyr, Lys, Leu, 0.747; Asn, Gly, His, Tyr, Leu, 0.747; Asn, Gly, Arg, Tyr, Leu, 0.747; Asn, Gln, His, Tyr, Orn, 0.747; Asn, Gln, Tyr, Ile, Trp, 0.747; Asn, His, Ala, Cit, Ile, 0.747; Asn, His, Ala, Lys, Ile, 0.747; Asn, His, Tyr, Orn, Ile, 0.747; Asn, His, Met, Ile, Trp, 0.747; Asn, His, Ile, Leu, Phe, 0.747; Asn, Ala, Cit, Tyr, Ile, 0.747; Asn, Cit, Tyr, Ile, Leu, 0.747; Asn, Arg, Tyr, Ile, Leu, 0.747; Asn, Tyr, Val, Leu, Phe, 0.747; Asn, Tyr, Orn, Leu, Phe, 0.747; Asn, Tyr, Leu, Phe, Trp, 0.747; Asn, Met, Orn, Lys, Ile, 0.747; Gly, Gln, His, Ile, Trp, 0.747; Gly, Gln, Thr, Tyr, Leu, 0.747; Gly, Gln, Ala, Lys, Ile, 0.747; Gly, His, Cit, Tyr, Ile, 0.747; Gln, His, Thr, Ile, Trp, 0.747; Gln, His, Cit, Tyr, Leu, 0.747; Gln, His, Tyr, Met, Lys, 0.747; Gln, Thr, Val, Lys, Ile, 0.747; Gln, Ala, Cit, Ile, Trp, 0.747; Gln, Ala, Tyr, Ile, Leu, 0.747; Gln, Cit, Tyr, Orn, Leu, 0.747; Gln, Tyr, Val, Lys, Leu, 0.747; Gln, Val, Met, Lys, Ile, 0.747; Gln, Val, Orn, Lys, Ile, 0.747; His, Arg, Met, Lys, Ile, 0.747; Thr, Pro, Tyr, Leu, Phe, 0.747; Thr, Tyr, Val, Leu, Phe, 0.747; Cit, Pro, Tyr, Val, Ile, 0.747; Arg, Tyr, Lys, Leu, Phe, 0.747; Tyr, Ile, Leu, Phe, Trp, 0.747; Ser, Gly, Cit, Tyr, Ile, 0.747; Ser, Gln, His, Orn, Ile, 0.747; Ser, Gln, Tyr, Val, Ile, 0.747; Ser, Gln, Tyr, Ile, Leu, 0.747; Ser, Gln, Lys, Leu, Phe, 0.747; Ser, Cit, Tyr, Lys, Ile, 0.747; Asn, Gly, His, Lys, Ile, 0.747; Asn, Gly, His, Ile, Phe, 0.747; Asn, Gly, Met, Lys, Ile, 0.747; Asn, Gln, Orn, Leu, Phe, 0.747; Asn, Gln, Ile, Leu, Trp, 0.747; Asn, His, Thr, Lys, Ile, 0.747; Asn, His, Cit, Ile, Phe, 0.747; Asn, His, Pro, Met, Ile, 0.747; Asn, His, Val, Lys, Phe, 0.747; Asn, His, Val, Ile, Phe, 0.747; Asn, His, Orn, Lys, Ile, 0.747; Asn, Cit, Pro, Tyr, Ile, 0.747; Asn, Cit, Tyr, Val, Ile, 0.747; Asn, Arg, Tyr, Orn, Lys, 0.747; Asn, Tyr, Met, Lys, Leu, 0.747; Gly, Gln, Pro, Tyr, Leu, 0.747; Gln, His, Thr, Orn, Ile, 0.747; Gln, His, Orn, Ile, Leu, 0.747; Gln, His, Orn, Leu, Phe, 0.747; Gln, His, Lys, Ile, Leu, 0.747; Gln, Thr, Tyr, Lys, Leu, 0.747; Gln, Ala, Cit, Lys, Ile, 0.747; Gln, Ala, Tyr, Lys, Ile, 0.747; Gln, Cit, Tyr, Met, Leu, 0.747; Gln, Cit, Tyr, Leu, Trp, 0.747; Gln, Cit, Lys, Ile, Leu, 0.747; Gln, Pro, Tyr, Met, Ile, 0.747; Gln, Pro, Tyr, Met, Leu, 0.747; Gln, Tyr, Orn, Lys, Ile, 0.747; Gln, Tyr, Orn, Lys, Leu, 0.747; Gln, Val, Ile, Leu, Phe, 0.747; Gln, Orn, Leu, Phe, Trp, 0.747; His, Ala, Tyr, Met, Ile, 0.747; His, Cit, Tyr, Val, Ile, 0.747; His, Tyr, Leu, Phe, Trp, 0.747; His, Met, Lys, Ile, Phe, 0.747; Thr, Cit, Tyr, Ile, Phe, 0.747; Thr, Tyr, Met, Leu, Phe, 0.747; Thr, Tyr, Lys, Leu, Phe, 0.747; Arg, Pro, Tyr, Orn, Lys, 0.747; Arg, Lys, Ile, Leu, Phe, 0.747; Tyr, Val, Met, Ile, Phe, 0.747; Tyr, Met, Orn, Ile, Phe, 0.747; Ser, Asn, Tyr, Leu, Phe, 0.746; Ser, Gln, His, Ala, Ile, 0.746; Ser, Gln, His, Tyr, Leu, 0.746; Ser, Gln, Thr, Tyr, Ile, 0.746; Ser, Gln, Thr, Lys, Ile, 0.746; Ser, Gln, Cit, Lys, Ile, 0.746; Ser, Gln, Arg, Tyr, Ile, 0.746; Ser, Gln, Met, Lys, Ile, 0.746; Asn, Gly, Tyr, Ile, Leu, 0.746; Asn, Gly, Orn, Lys, Ile, 0.746; Asn, Gln, His, Lys, Leu, 0.746; Asn, Gln, Pro, Tyr, Ile, 0.746; Asn, Gln, Val, Lys, Phe, 0.746; Asn, His, Cit, Pro, Ile, 0.746; Asn, His, Arg, Orn, Ile, 0.746; Asn, His, Tyr, Val, Ile, 0.746; Asn, Thr, Tyr, Lys, Leu, 0.746; Asn, Cit, Tyr, Lys, Leu, 0.746; Asn, Arg, Tyr, Val, Ile, 0.746; Asn, Orn, Lys, Ile, Phe, 0.746; Asn, Lys, Ile, Leu, Trp, 0.746; Gly, Gln, His, Tyr, Val, 0.746; Gly, Gln, Arg, Tyr, Leu, 0.746; Gly, Gln, Ile, Leu, Phe, 0.746; Gly, Ala, Cit, Tyr, Ile, 0.746; Gln, Thr, Met, Lys, Ile, 0.746; Gln, Thr, Orn, Lys, Ile, 0.746; Gln, Thr, Orn, Leu, Phe, 0.746; Gln, Thr, Lys, Ile, Leu, 0.746; Gln, Ala, Tyr, Leu, Phe, 0.746; Gln, Ala, Ile, Leu, Trp, 0.746; Gln, Cit, Arg, Tyr, Ile, 0.746; Gln, Cit, Tyr, Val, Ile, 0.746; Gln, Arg, Tyr, Met, Ile, 0.746; Gln, Arg, Tyr, Ile, Trp, 0.746; Gln, Pro, Tyr, Lys, Ile, 0.746; Gln, Pro, Tyr, Ile, Trp, 0.746; Gln, Tyr, Val, Met, Leu, 0.746; Thr, Tyr, Met, Ile, Phe, 0.746; Ala, Cit, Tyr, Ile, Phe, 0.746; Cit, Arg, Pro, Tyr, Lys, 0.746; Cit, Pro, Tyr, Lys, Ile, 0.746; Cit, Tyr, Orn, Lys, Ile, 0.746; Cit, Tyr, Orn, Ile, Trp, 0.746; Cit, Tyr, Lys, Ile, Phe, 0.746; Ser, Asn, Gln, Leu, Phe, 0.745; Ser, Asn, His, Ile, Phe, 0.745; Ser, Gly, Gln, Tyr, Leu, 0.745; Ser, Gln, His, Thr, Ile, 0.745; Ser, Gln, His, Pro, Ile, 0.745; Ser, Gln, His, Ile, Leu, 0.745; Ser, Gln, His, Ile, Trp, 0.745; Ser, Cit, Tyr, Orn, Ile, 0.745; Ser, Tyr, Met, Leu, Phe, 0.745; Asn, Gly, Tyr, Val, Leu, 0.745; Asn, Gly, Tyr, Leu, Trp, 0.745; Asn, Gln, His, Orn, Lys, 0.745; Asn, His, Ala, Tyr, Ile, 0.745; Asn, His, Cit, Orn, Ile, 0.745; Asn, His, Pro, Lys, Ile, 0.745; Asn, His, Lys, Ile, Trp, 0.745; Asn, Thr, Cit, Tyr, Ile, 0.745; Asn, Thr, Tyr, Lys, Ile, 0.745; Asn, Thr, Lys, Ile, Phe, 0.745; Asn, Thr, Lys, Ile, Trp, 0.745; Asn, Pro, Lys, Ile, Phe, 0.745; Asn, Tyr, Lys, Ile, Leu, 0.745; Asn, Val, Met, Lys, Ile, 0.745; Asn, Val, Lys, Ile, Phe, 0.745; Gly, Gln, His, Thr, Ile, 0.745; Gly, Gln, Pro, Lys, Ile, 0.745; Gly, Gln, Lys, Ile, Leu, 0.745; Gly, Gln, Lys, Leu, Phe, 0.745; Gly, Cit, Pro, Tyr, Ile, 0.745; Gly, Cit, Tyr, Orn, Ile, 0.745; Gln, His, Thr, Lys, Ile, 0.745; Gln, Ala, Cit, Arg, Ile, 0.745; Gln, Ala, Val, Lys, Ile, 0.745; Gln, Ala, Lys, Ile, Phe, 0.745; Gln, Cit, Val, Orn, Ile, 0.745; Gln, Tyr, Met, Lys, Leu, 0.745; Gln, Met, Lys, Ile, Leu, 0.745; Ala, Cit, Tyr, Val, Ile, 0.745; Ala, Tyr, Met, Lys, Ile, 0.745; Cit, Arg, Tyr, Ile, Phe, 0.745; Cit, Tyr, Met, Ile, Phe, 0.745; Cit, Tyr, Orn, Ile, Phe, 0.745; Ser, Asn, Gly, Tyr, Leu, 0.745; Ser, Gln, His, Met, Ile, 0.745; Ser, Gln, His, Lys, Ile, 0.745; Ser, Gln, Pro, Tyr, Ile, 0.745; Ser, Gln, Tyr, Met, Ile, 0.745; Ser, Cit, Tyr, Ile, Trp, 0.745; Ser, Arg, Orn, Lys, Ile, 0.745; Ser, Tyr, Met, Lys, Ile, 0.745; Asn, Gly, Pro, Tyr, Leu, 0.745; Asn, Gly, Lys, Ile, Leu, 0.745; Asn, Gln, Ala, Tyr, Leu, 0.745; Asn, Gln, Cit, Pro, Ile, 0.745; Asn, Gln, Arg, Tyr, Leu, 0.745; Asn, Gln, Tyr, Met, Ile, 0.745; Asn, Gln, Val, Leu, Phe, 0.745; Asn, Gln, Met, Lys, Leu, 0.745; Asn, His, Pro, Ile, Phe, 0.745; Asn, His, Val, Met, Lys, 0.745; Asn, Thr, Pro, Lys, Ile, 0.745; Gly, Gln, Tyr, Val, Lys, 0.745; Gly, Gln, Orn, Lys, Leu, 0.745; Gly, Cit, Tyr, Lys, Ile, 0.745; Gln, His, Pro, Lys, Ile, 0.745; Gln, His, Val, Lys, Ile, 0.745; Gln, His, Met, Lys, Ile, 0.745; Gln, His, Lys, Leu, Phe, 0.745; Gln, Thr, Arg, Tyr, Ile, 0

.745; Gln, Thr, Tyr, Met, Ile, 0.745; Gln, Thr, Tyr, Ile, Trp, 0.745; Gln, Ala, Tyr, Met, Leu, 0.745; Gln, Cit, Val, Lys, Ile, 0.745; Gln, Cit, Met, Lys, Ile, 0.745; Gln, Arg, Tyr, Val, Lys, 0.745; Gln, Val, Orn, Leu, Phe, 0.745; Gln, Met, Orn, Lys, Ile, 0.745; His, Cit, Tyr, Ile, Trp, 0.745; His, Arg, Tyr, Orn, Ile, 0.745; His, Arg, Lys, Ile, Trp, 0.745; Thr, Tyr, Orn, Leu, Phe, 0.745; Ala, Tyr, Met, Ile, Phe, 0.745; Ala, Tyr, Lys, Ile, Phe, 0.745; Arg, Orn, Lys, Ile, Trp, 0.745; Pro, Tyr, Met, Leu, Phe, 0.745; Tyr, Met, Lys, Ile, Trp, 0.745; Tyr, Met, Ile, Phe, Trp, 0.745; Tyr, Lys, Ile, Phe, Trp, 0.745; Ser, Asn, His, Met, Ile, 0.744; Ser, Asn, Thr, Lys, Ile, 0.744; Ser, Asn, Lys, Ile, Phe, 0.744; Ser, Gln, Ala, Tyr, Ile, 0.744; Ser, Gln, Orn, Lys, Ile, 0.744; Ser, Gln, Lys, Leu, Trp, 0.744; Ser, Ala, Arg, Lys, Ile, 0.744; Ser, Cit, Tyr, Ile, Phe, 0.744; Ser, Tyr, Met, Ile, Phe, 0.744; Asn, Gly, His, Val, Lys, 0.744; Asn, Gln, Arg, Ile, Leu, 0.744; Asn, Gln, Tyr, Val, Leu, 0.744; Asn, Gln, Val, Ile, Leu, 0.744; Asn, His, Thr, Met, Ile, 0.744; Asn, His, Ala, Orn, Ile, 0.744; Asn, His, Val, Lys, Ile, 0.744; Asn, Pro, Met, Lys, Ile, 0.744; Asn, Tyr, Met, Ile, Phe, 0.744; Gly, Gln, Cit, Arg, Ile, 0.744; Gly, Gln, Cit, Ile, Phe, 0.744; Gly, Gln, Tyr, Val, Trp, 0.744; Gly, Tyr, Met, Lys, Ile, 0.744; Gln, His, Ala, Leu, Trp, 0.744; Gln, His, Arg, Tyr, Val, 0.744; Gln, His, Tyr, Orn, Phe, 0.744; Gln, Thr, Val, Leu, Phe, 0.744; Gln, Ala, Tyr, Met, Ile, 0.744; Gln, Ala, Lys, Leu, Phe, 0.744; Gln, Cit, Arg, Pro, Ile, 0.744; Gln, Cit, Tyr, Ile, Leu, 0.744; Gln, Arg, Tyr, Lys, Leu, 0.744; Gln, Tyr, Val, Met, Lys, 0.744; Gln, Val, Lys, Leu, Phe, 0.744; Gln, Orn, Lys, Ile, Leu, 0.744; His, Ala, Cit, Tyr, Ile, 0.744; His, Cit, Tyr, Orn, Ile, 0.744; His, Arg, Orn, Ile, Phe, 0.744; Ala, Arg, Met, Lys, Ile, 0.744; Arg, Tyr, Val, Met, Lys, 0.744; Ser, Gln, His, Val, Ile, 0.743; Ser, Cit, Tyr, Val, Ile, 0.743; Asn, Gly, Val, Lys, Ile, 0.743; Asn, Gln, Ala, Cit, Ile, 0.743; Asn, Val, Orn, Lys, Ile, 0.743; Gly, Gln, Tyr, Val, Met, 0.743; Gly, Tyr, Lys, Ile, Phe, 0.743; Gln, His, Pro, Orn, Ile, 0.743; Gln, Arg, Pro, Tyr, Ile, 0.743; Gln, Arg, Tyr, Orn, Ile, 0.743; Cit, Tyr, Ile, Phe, Trp, 0.743; Arg, Pro, Lys, Ile, Phe, 0.743; Pro, Tyr, Met, Lys, Ile, 0.743; Pro, Tyr, Lys, Ile, Phe, 0.743; Ser, Asn, His, Val, Lys, 0.743; Ser, Asn, Tyr, Met, Leu, 0.743; Ser, Asn, Tyr, Ile, Leu, 0.743; Ser, Gln, Cit, Tyr, Ile, 0.743; Ser, Gln, Tyr, Orn, Ile, 0.743; Ser, Gln, Lys, Ile, Leu, 0.743; Ser, His, Arg, Tyr, Ile, 0.743; Asn, Gly, Gln, Leu, Phe, 0.743; Asn, Gly, His, Tyr, Val, 0.743; Asn, Gly, Tyr, Met, Ile, 0.743; Asn, Gln, Ala, Tyr, Ile, 0.743; Asn, Gln, Ala, Ile, Leu, 0.743; Asn, Gln, Cit, Val, Ile, 0.743; Asn, Gln, Cit, Ile, Leu, 0.743; Asn, Gln, Arg, Leu, Phe, 0.743; Asn, Gln, Tyr, Orn, Ile, 0.743; Asn, His, Tyr, Lys, Leu, 0.743; Asn, His, Orn, Ile, Trp, 0.743; Asn, Arg, Orn, Lys, Leu, 0.743; Asn, Orn, Lys, Ile, Trp, 0.743; Gly, Tyr, Leu, Phe, Trp, 0.743; Gln, His, Pro, Tyr, Val, 0.743; Gln, His, Tyr, Val, Met, 0.743; Gln, His, Tyr, Val, Phe, 0.743; Gln, His, Orn, Lys, Leu, 0.743; Gln, Thr, Cit, Lys, Ile, 0.743; Gln, Thr, Tyr, Lys, Ile, 0.743; Gln, Ala, Cit, Orn, Ile, 0.743; Gln, Cit, Val, Ile, Leu, 0.743; Gln, Cit, Orn, Ile, Leu, 0.743; Gln, Pro, Lys, Ile, Trp, 0.743; Gln, Tyr, Val, Met, Ile, 0.743; His, Arg, Met, Ile, Phe, 0.743; Thr, Cit, Tyr, Leu, Phe, 0.743; Cit, Pro, Tyr, Met, Ile, 0.743; Arg, Tyr, Leu, Phe, Trp, 0.743; Pro, Tyr, Met, Ile, Phe, 0.743; Ser, Asn, His, Cit, Ile, 0.743; Ser, Gly, Gln, Leu, Phe, 0.743; Ser, Gln, Cit, Orn, Ile, 0.743; Asn, Gly, His, Met, Ile, 0.743; Asn, Gly, His, Orn, Ile, 0.743; Asn, Gly, Tyr, Orn, Leu, 0.743; Asn, Gly, Tyr, Lys, Ile, 0.743; Asn, Gln, Thr, Arg, Ile, 0.743; Asn, Gln, Thr, Tyr, Ile, 0.743; Asn, His, Ala, Arg, Ile, 0.743; Asn, His, Val, Met, Ile, 0.743; Asn, Thr, Ala, Lys, Ile, 0.743; Asn, Ala, Orn, Lys, Ile, 0.743; Asn, Ala, Lys, Ile, Leu, 0.743; Asn, Arg, Pro, Tyr, Ile, 0.743; Asn, Pro, Orn, Lys, Ile, 0.743; Asn, Met, Lys, Ile, Trp, 0.743; Gly, Gln, Orn, Leu, Phe, 0.743; Gly, His, Arg, Ile, Phe, 0.743; Gly, Thr, Cit, Tyr, Ile, 0.743; Gly, Cit, Tyr, Ile, Leu, 0.743; Gln, His, Ala, Lys, Ile, 0.743; Gln, His, Tyr, Val, Lys, 0.743; Gln, His, Tyr, Lys, Phe, 0.743; Gln, Thr, Cit, Ile, Leu, 0.743; Gln, Thr, Arg, Tyr, Leu, 0.743; Gln, Thr, Tyr, Leu, Trp, 0.743; Gln, Ala, Cit, Ile, Leu, 0.743; Gln, Ala, Met, Lys, Ile, 0.743; Gln, Cit, Arg, Ile, Trp, 0.743; Gln, Cit, Pro, Lys, Ile, 0.743; Gln, Cit, Val, Ile, Phe, 0.743; Gln, Arg, Tyr, Leu, Trp, 0.743; Gln, Pro, Val, Lys, Ile, 0.743; Gln, Pro, Met, Lys, Ile, 0.743; Gln, Tyr, Orn, Ile, Trp, 0.743; Gln, Orn, Lys, Leu, Trp, 0.743; His, Ala, Arg, Tyr, Ile, 0.743; His, Arg, Pro, Tyr, Ile, 0.743; His, Arg, Orn, Lys, Ile, 0.743; His, Tyr, Val, Ile, Phe, 0.743; Thr, Tyr, Met, Lys, Ile, 0.743; Ala, Cit, Tyr, Met, Ile, 0.743; Cit, Arg, Tyr, Ile, Trp, 0.743; Cit, Arg, Orn, Lys, Ile, 0.743; Cit, Tyr, Val, Ile, Trp, 0.743; Cit, Tyr, Met, Leu, Phe, 0.743; Pro, Tyr, Ile, Leu, Phe, 0.743; Ser, Asn, Tyr, Val, Ile, 0.742; Ser, Asn, Val, Lys, Leu, 0.742; Ser, Gly, Gln, His, Ile, 0.742; Ser, Gln, Tyr, Met, Leu, 0.742; Ser, His, Cit, Tyr, Ile, 0.742; Ser, Tyr, Val, Ile, Phe, 0.742; Asn, Gly, Tyr, Val, Met, 0.742; Asn, Gly, Tyr, Val, Ile, 0.742; Asn, Gly, Lys, Ile, Phe, 0.742; Asn, Gly, Lys, Ile, Trp, 0.742; Asn, Gln, Val, Orn, Leu, 0.742; Asn, Gln, Met, Leu, Phe, 0.742; Asn, Gln, Orn, Leu, Trp, 0.742; Asn, His, Thr, Cit, Ile, 0.742; Asn, His, Thr, Arg, Ile, 0.742; Asn, His, Ala, Ile, Phe, 0.742; Asn, His, Pro, Orn, Ile, 0.742; Asn, Arg, Tyr, Val, Lys, 0.742; Asn, Arg, Tyr, Met, Ile, 0.742; Asn, Pro, Tyr, Lys, Leu, 0.742; Asn, Tyr, Val, Lys, Ile, 0.742; Asn, Tyr, Met, Orn, Leu, 0.742; Asn, Val, Lys, Ile, Trp, 0.742; Asn, Orn, Lys, Leu, Phe, 0.742; Gly, Gln, Cit, Ile, Leu, 0.742; Gly, Gln, Cit, Ile, Trp, 0.742; Gly, Thr, Tyr, Leu, Phe, 0.742; Gly, Arg, Met, Lys, Ile, 0.742; Gln, His, Ala, Orn, Ile, 0.742; Gln, His, Ala, Lys, Phe, 0.742; Gln, His, Arg, Tyr, Leu, 0.742; Gln, His, Arg, Orn, Leu, 0.742; Gln, His, Tyr, Met, Phe, 0.742; Gln, Ala, Cit, Met, Ile, 0.742; Gln, Ala, Arg, Tyr, Ile, 0.742; Gln, Ala, Tyr, Val, Leu, 0.742; Gln, Ala, Tyr, Ile, Trp, 0.742; Gln, Cit, Tyr, Met, Ile, 0.742; Gln, Cit, Ile, Leu, Trp, 0.742; Gln, Arg, Pro, Lys, Ile, 0.742; Gln, Arg, Tyr, Val, Ile, 0.742; Gln, Pro, Ile, Leu, Phe, 0.742; Gln, Val, Lys, Leu, Trp, 0.742; His, Thr, Lys, Ile, Phe, 0.742; Thr, Tyr, Leu, Phe, Trp, 0.742; Ala, Cit, Pro, Tyr, Ile, 0.742; Ala, Cit, Tyr, Orn, Ile, 0.742; Ala, Arg, Pro, Tyr, Lys, 0.742; Cit, Tyr, Lys, Ile, Leu, 0.742; Arg, Met, Orn, Lys, Ile, 0.742; Ser, Asn, Lys, Ile, Leu, 0.742; Ser, Asn, Lys, Leu, Phe, 0.742; Ser, Gln, Thr, Leu, Phe, 0.742; Ser, Gln, Pro, Lys, Ile, 0.742; Asn, Gly, Gln, Val, Lys, 0.742; Asn, Gly, Tyr, Val, Lys, 0.742; Asn, Gln, His, Ala, Leu, 0.742; Asn, Gln, Thr, Ile, Leu, 0.742; Asn, Gln, Orn, Ile, Leu, 0.742; Asn, His, Thr, Ile, Leu, 0.742; Asn, His, Cit, Val, Lys, 0.742; Asn, His, Arg, Met, Ile, 0.742; Asn, His, Val, Lys, Trp, 0.742; Asn, Ala, Tyr, Lys, Leu, 0.742; Asn, Cit, Tyr, Met, Leu, 0.742; Asn, Arg, Tyr, Ile, Phe, 0.742; Asn, Pro, Tyr, Lys, Ile, 0.742; Asn, Tyr, Met, Leu, Trp, 0.742; Gly, Gln, His, Pro, Tyr, 0.742; Gly, Gln, His, Orn, Leu, 0.742; Gly, Gln, Cit, Val, Ile, 0.742; Gly, Gln, Val, Orn, Leu, 0.742; Gly, Gln, Orn, Ile, Leu, 0.742; Gly, Cit, Arg, Tyr, Ile, 0.742; Gly, Tyr, Met, Ile, Phe, 0.742; Gly, Tyr, Ile, Leu, Phe, 0.742; Gln, His, Tyr, Met, Orn, 0.742; Gln, His, Tyr, Phe, Trp, 0.742; Gln, Thr, Cit, Orn, Ile, 0.742; Gln, Thr, Orn, Ile, Leu, 0.742; Gln, Thr, Ile, Leu, Phe, 0.742; Gln, Ala, Orn, Lys, Ile, 0.742; Gln, Cit, Arg, Ile, Phe, 0.742; Gln, Cit, Pro, Met, Ile, 0.742; Gln, Cit, Pro, Ile, Trp, 0.742; Gln, Cit, Met, Orn, Ile, 0.742; Gln, Tyr, Met, Orn, Ile, 0.742; Gln, Lys, Leu, Phe, Trp, 0.742; His, Cit, Pro, Tyr, Ile, 0.742; Cit, Arg, Lys, Ile, Trp, 0.742; Cit, Tyr, Val, Ile, Leu, 0.742; Cit, Tyr, Met, Ile, Trp, 0.742; Arg, Val, Orn, Lys, Ile, 0.742; Tyr, Met, Leu, Phe, Trp, 0.742; Ser, Gln, His, Orn, Leu, 0.741; Ser, Gln, Cit, Tyr, Leu, 0.741; Ser, Gln, Tyr, Val, Leu, 0.741; Ser, Tyr, Ile, Leu, Phe, 0.741; Asn, Gly, His, Ala, Ile, 0.741; Asn, Gly, Lys, Leu, Phe, 0.741; Asn, Gln, Thr, Orn, Leu, 0.741; Asn, Gln, Cit, Ile, Phe, 0.741; Asn, Gln, Cit, Leu, Phe, 0.741; Asn, Gln, Pro, Orn, Ile, 0.741; Asn, His, Thr, Tyr, Ile, 0.741; Asn, His, Arg, Tyr, Lys, 0.741; Asn, His, Arg, Val, Ile, 0.741; Asn, His, Arg, Ile, Trp, 0.741; Asn, His, Pro, Val, Ile, 0.741; Asn, His, Val, Ile, Trp, 0.741; Asn, His, Met, Ile, Leu, 0.741; Asn, Arg, Val, Orn, Lys, 0.741; Asn, Tyr, Val, Ile, Leu, 0.741; Asn, Val, Lys, Leu, Phe, 0.741; Gly, Gln, Cit, Met, Ile, 0.741; Gly, Gln, Arg, Tyr, Val, 0.741; Gly, Gln, Arg, Leu, Phe, 0.741; Gly, Gln, Met, Orn, Leu, 0.741; Gly, His, Lys, Ile, Phe, 0.741; Gly, Arg, Tyr, Val, Lys, 0.741; Gly, Tyr, Met, Ile, Leu, 0.741; Gln, His, Ala, Tyr, Lys, 0.741; Gln, His, Arg, Tyr, Phe, 0.741; Gln, His, Pro, Tyr, Lys, 0.741; Gln, Thr, Ala, Lys, Ile, 0.741; Gln, Thr, Arg, Orn, Ile, 0.741; Gln, Thr, Leu, Phe, Trp, 0.741; Gln, Ala, Cit, Pro, Ile, 0.741; Gln, Cit, Arg, Ile, Leu, 0.741; Gln, Cit, Pro, Ile, Leu, 0.741; Gln, Cit, Tyr, Val, Leu, 0.741; Gln, Arg, Orn, Leu, Phe, 0.741; Gln, Arg, Lys, Leu, Phe, 0.741; Gln, Pro, Orn, Lys, Ile, 0.741; Gln, Tyr, Val, Orn, Leu, 0.741; Gln, Tyr, Val, Lys, Phe, 0.741; His, Thr, Arg, Ile, Phe, 0.741; His, Thr, Tyr, Leu, Phe, 0.741; Thr, Cit, Tyr, Met, Ile, 0.741; Thr, Cit, Tyr, Orn, Ile, 0.741; Thr, Arg, Tyr, Leu, Phe, 0.741; Thr, Arg, Lys, Ile, Leu, 0.741; Cit, Tyr, Val, Ile, Phe, 0.741; Arg, Pro, Tyr, Met, Lys, 0.741; Arg, Orn, Lys, Ile, Leu, 0.741; Tyr, Val, Ile, Leu, Phe, 0.741; Tyr, Met, Lys, Leu, Phe, 0.741; Tyr, Met, Ile, Leu, Trp, 0.741; Tyr, Orn, Lys, Ile, Phe, 0.741; Ser, Asn, Gln, Thr, Leu, 0.74; Ser, Asn, Gln, Val, Lys, 0.74; Ser, Asn, His, Ala, Ile, 0.74; Ser, Gln, Ala, Tyr, Leu, 0.74; Ser, Gln, Orn, Leu, Phe, 0.74; Ser, Thr, Arg, Lys, Ile, 0.74; Ser, Tyr, Lys, Ile, Phe, 0.74; Asn, Gly, Gln, Ile, Leu, 0.74; Asn, Gly, His, Arg, Ile, 0.74; Asn, Gly, Pro, Lys, Ile, 0.74; Asn, Gly, Ile, Leu, Phe, 0.74; Asn, Gln, His, Val, Lys, 0.74; Asn, Gln, Thr, Val, Lys, 0.74; Asn, Gln, Pro, Ile, Phe, 0.74; Asn, Gln,

 Met, Orn, Leu, 0.74; Asn, Gln, Met, Ile, Leu, 0.74; Asn, His, Thr, Val, Ile, 0.74; Asn, His, Cit, Ile, Leu, 0.74; Asn, His, Arg, Pro, Ile, 0.74; Asn, Thr, Pro, Tyr, Leu, 0.74; Asn, Ala, Arg, Tyr, Ile, 0.74; Asn, Ala, Tyr, Val, Ile, 0.74; Asn, Ala, Tyr, Lys, Ile, 0.74; Asn, Ala, Tyr, Ile, Leu, 0.74; Asn, Cit, Ile, Leu, Phe, 0.74; Asn, Pro, Tyr, Met, Leu, 0.74; Asn, Pro, Tyr, Ile, Leu, 0.74; Asn, Pro, Val, Lys, Ile, 0.74; Asn, Tyr, Val, Met, Leu, 0.74; Asn, Tyr, Val, Lys, Leu, 0.74; Asn, Tyr, Orn, Lys, Ile, 0.74; Asn, Tyr, Lys, Ile, Trp, 0.74; Asn, Met, Lys, Leu, Phe, 0.74; Gly, Gln, His, Tyr, Lys, 0.74; Gly, Gln, His, Leu, Phe, 0.74; Gly, Gln, Ala, Tyr, Val, 0.74; Gly, Gln, Orn, Leu, Trp, 0.74; Gly, Gln, Lys, Leu, Trp, 0.74; Gly, Arg, Orn, Lys, Ile, 0.74; Gln, His, Thr, Tyr, Leu, 0.74; Gln, His, Ala, Orn, Leu, 0.74; Gln, His, Tyr, Lys, Trp, 0.74; Gln, Thr, Lys, Leu, Trp, 0.74; Gln, Ala, Lys, Ile, Leu, 0.74; Gln, Cit, Pro, Ile, Phe, 0.74; Gln, Cit, Met, Ile, Trp, 0.74; Gln, Arg, Tyr, Met, Leu, 0.74; Gln, Pro, Orn, Ile, Leu, 0.74; Gln, Pro, Lys, Ile, Phe, 0.74; Gln, Val, Orn, Ile, Leu, 0.74; His, Cit, Tyr, Ile, Leu, 0.74; His, Tyr, Met, Leu, Phe, 0.74; Thr, Arg, Orn, Lys, Ile, 0.74; Ala, Tyr, Ile, Leu, Phe, 0.74; Cit, Pro, Tyr, Ile, Phe, 0.74; Cit, Tyr, Val, Lys, Ile, 0.74; Arg, Tyr, Met, Leu, Phe, 0.74; Arg, Lys, Ile, Leu, Trp, 0.74; Tyr, Met, Orn, Lys, Ile, 0.74; Tyr, Orn, Leu, Phe, Trp, 0.74; Tyr, Lys, Leu, Phe, Trp, 0.74 [4. Five-variable formula including amino acids]
Arg, Tyr, Lys, Ile, Phe, 0.776; Gln, His, Tyr, Ile, Phe, 0.774; Gln, Tyr, Lys, Ile, Phe, 0.771; Asn, Arg, Tyr, Lys, Ile, 0.77; His, Cit, Ile, Phe, 0.77; Asn, Gln, His, Ile, Phe, 0.769; Gln, His, Arg, Tyr, Ile, 0.769; Ser, Gln, Tyr, Ile, Phe, 0.768; Tyr, Leu, Phe, 0.768; Gln, His, Tyr, Ile, Trp, 0.768; Gln, Tyr, Ile, Leu, Phe, 0.768; Asn, Gln, His, Cit, Ile, 0.767; Tyr, Ile, 0.766; Gln, His, Cit, Pro, Ile, 0.766; Gln, His, Cit, Orn, Ile, 0.766; Asn, Gln, His, Ala, Ile, 0.765; Phe, 0.765; Gln, His, Tyr, Val, Ile, 0.765; Gln, His, Tyr, Orn, Ile, 0.765; Gln, Arg, Lys, Ile, Phe, 0.765; Gln, His, Ile, Leu, Phe, 0.764; Asn, Gly, Gln, Tyr, Ile, 0.764; Asn, His, Cit, Tyr, Ile, 0.764; Gly, Arg, Tyr, Lys, Ile, 0.764; Gln, His, Tyr, Met, Ile, 0.764; Gln, Tyr, Met, Ile, Phe, 0.764; Gly, Gln, Tyr, Leu, Trp, 0.763; Gln, His, Cit, Tyr, Ile, 0.763; His, Tyr, Ile, Leu, 0.763; Gln, His, Ile, Phe, Trp, 0.763; Gln, Arg, Lys, Ile, Trp, 0.763; Asn, Gly, Cit, Tyr, Ile, 0.763; Asn, Gln, Tyr, Ile, Phe, 0.763; Gly, Gln, Tyr, Ile, Phe, 0.763; Tyr, Ile, 0.763; Gln, His, Pro, Tyr, Ile, 0.763; Gln, Tyr, Leu, Phe, Trp, 0.763; Arg, Tyr, Met, Lys, Ile, 0.763; Ile, 0.762; Asn, Gln, His, Orn, Ile, 0.762; Gln, His, Ala, Cit, Ile, 0.762; Gln, Thr, Tyr, Ile, Phe, 0.762; Gln, Tyr, Ile, Phe, Trp, 0.762; Ser, Gln, His, Tyr, Ile, 0.761; Asn, Gly, Cit, Lys, Ile, 0.761; Asn, Gln, His, Arg, Ile, 0.761; Asn, Cit, Tyr, Lys, Ile, 0.761; Asn, Arg, Lys, Ile, Phe, 0.761; Gly, Gln, His, Tyr, Leu, 0.761; Gln, Tyr, Val, Ile, Phe, 0.761; Arg, Tyr, Lys, Ile, 0.761; Asn, Gly, Gln, Lys, Ile, 0.761; Asn, Gln, His, Val, Ile, 0.761; Asn, Gln, Arg, Lys, Ile, 0.761; Arg, Lys, Ile, 0.761; Gln, His, Thr, Tyr, Ile, 0.761; Gln, His, Val, Ile, Phe, 0.761; Gln, Pro, Tyr, Ile, Phe, 0.761; Ile, Phe, 0.761; Asn, Gln, His, Ile, Leu, 0.76; Asn, Arg, Pro, Tyr, Lys, 0.76; Asn, Arg, Orn, Lys, Ile, 0.76; Gly, Gln, Tyr, Lys, Ile, 0.76; Gln, His, Cit, Ile, Trp, 0.76; Gln, Arg, Orn, Lys, Ile, 0.76; Gln, Tyr, Orn, Ile, Phe, 0.76; His, Tyr, Met, Lys, Ile, 0.76; Asn, Gly, Gln, Lys, Leu, 0.759; Asn, Gly, Arg, Lys, Ile, 0.759; Asn, Gln, His, Met, Ile, 0.759; Asn, Gln, Lys, Ile, Phe, 0.759; Gln, His, Cit, Arg, Ile, 0.759; His, Cit, Ile, Leu, 0.759; Gln, His, Met, Ile, Phe, 0.759; Tyr, Met, Lys, Ile, Phe, 0.759; Ser, Asn, Arg, Lys, Ile, 0.759; His, Tyr, Leu, 0.759; Asn, Gln, Lys, Leu, Phe, 0.759; Gln, His, Ala, Ile, Trp, 0.759; Gln, His, Cit, Val, Ile, 0.759; Lys, Leu, 0.759; Gln, Cit, Arg, Lys, Ile, 0.759; Gln, Arg, Val, Lys, Ile, 0.759; Ser, Gly, Gln, Tyr, Ile, 0.758; Ile, 0.758; Asn, Gln, His, Lys, Ile, 0.758; Asn, Cit, Pro, Lys, Ile, 0.758; Asn, Tyr, Met, Lys, Ile, 0.758; Gly, Gln, Tyr, Ile, Leu, 0.758; Gln, His, Ala, Met, Ile, 0.758; Gln , His, Cit, Met, Ile, 0.758; Gln, Tyr, Orn, Leu, Phe, 0.758; Gln, Tyr, Lys, Leu, Phe, 0.758; His, Arg, Tyr, Lys, Ile, 0.758; Ser, His, Tyr, Ile, Phe, 0.757; Gln, His, Ala, Ile, Phe, 0.757; Arg, Pro, Tyr, Lys, Ile, 0.757; Ser, Gln, Arg Asn, His, Lys, Ile, Phe, 0.757; Gln, His, Tyr, Leu, Trp, 0.757; Gln, His, Val, Met, Ile, 0.757; Arg, Tyr, Lys, Ile Asn, Gly, Gln, Tyr, Leu, 0.757; Asn, Gln, His, Ile, Trp, 0.757; Asn, His, Cit, Lys, Ile, 0.757; Asn, His, Arg, Tyr, Ile Asn, Thr, Tyr, Leu, Phe, 0.757; Asn, Cit, Arg, Lys, Ile, 0.757; Asn, Cit, Lys, Ile, Leu, 0.757; Asn, Arg, Lys, Ile, Leu, 0.757 Asn, Arg, Lys, Ile, Trp, 0.757; Gly, Gln, His, Cit, Ile, 0.757; Gly, Gln, Tyr, Met, Ile, 0.757; Gln, His, Thr, Cit, Ile, 0.757; , His, Arg, Pro, Ile, 0.757; Gln, Thr, Arg, Lys, Ile, 0.757; Gln, Thr, Tyr, Leu, Phe, 0.757; Gln, Pro, Tyr, Leu, Phe, 0.757; , Ile, Leu, Trp, 0.757; Cit, Arg, Tyr, Lys, Ile, 0.757; Asn, Gln, T hr, Leu, Phe, 0.756; Asn, Gln, Val, Lys, Ile, 0.756; Asn, Cit, Tyr, Ile, Phe, 0.756; Asn, Cit, Orn, Lys, Ile, 0.756; Orn, Ile, 0.756; Gln, His, Orn, Ile, Phe, 0.756; Gln, Cit, Tyr, Ile, Phe, 0.756; Gln, Cit, Ile, Leu, Phe, 0.756; Ile, 0.756; Gln, Tyr, Met, Leu, Phe, 0.756; His, Tyr, Met, Ile, Phe, 0.756; Arg, Tyr, Orn, Lys, Ile, 0.756; Asn, Gln, His, Thr, Ile, 0.756; Asn, Gln, Cit, Lys, Ile, 0.756; Asn, Gln, Tyr, Lys, Leu, 0.756; Asn, Gln, Tyr, Ile, Leu, 0.756; Asn, Gln, Lys, Ile, Leu, 0.756; Asn, Tyr, Lys, Leu, Phe, 0.756; Asn, Lys, Ile, Leu, Phe, 0.756; Gly, Gln, Lys, Ile, Phe, 0.756; His, Lys, Ile, Phe, 0.756; Ser, Asn, Gln, His, Ile, 0.755; Asn, Thr, Arg, Lys, Ile, 0.755; Asn, Arg, Val, Lys, Ile, 0.755; Cit, Tyr, Ile, 0.755; Gly, Gln, Tyr, Lys, Leu, 0.755; Gln, His, Ala, Arg, Ile, 0.755; Gln, His, Tyr, Lys, Ile, 0.755; Ile, Phe, 0.755; His, Tyr, Ile, Leu, Phe, 0.755; Thr, Arg, Tyr, Lys, Ile, 0.755; Arg, Tyr, Val, Lys, Ile, 0.755; Ser, Asn, Gln, Lys, Ile, 0.754; Ser, Gln, Tyr, Leu, Trp, 0.754; Asn, Gln, Tyr, Lys, Ile, 0.754; Asn, Gln, Ile, Leu, Phe, 0.754; Asn, His, Tyr, Met, Ile, 0.754; Asn, His, Tyr, Ile, Leu, 0.754; Asn, Thr, Lys, Ile, Leu, 0.754; Asn, Cit, Tyr, Orn, Ile, 0.754; Gln, His, Thr, Ile, Phe, 0.754; Gln, His, Arg, Val, Ile, 0.754; His, Arg, Lys, Ile, 0.754; Gln, His, Tyr, Val, Trp, 0.754; Gln, His, Met, Ile, Leu, 0.754; His, Ala, Tyr, Ile, Phe, 0.754; Tyr, Met, Ile, 0.754; His, Tyr, Met, Ile, Trp, 0.754; Ser, Gln, His, Ile, Phe, 0.754; 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Ser, Gln, Thr, Tyr, Ile, 0.746; Ser, Gln, Thr, Lys, Ile, 0.746; Ser, Gln, Cit, Lys, Ile, 0.746; Arg, Tyr, Ile, 0.746; Ser, Gln, Met, Lys, Ile, 0.746; Asn, Gly, Tyr, Ile, Leu, 0.746; Asn, Gly, Orn, Lys, Ile, 0.746; Lys, Leu, 0.746; Asn, Gln, Pro, Tyr, Ile, 0.746; Asn, Gln, Val, Ly Asn, His, Cit, Pro, Ile, 0.746; Asn, His, Arg, Orn, Ile, 0.746; Asn, His, Tyr, Val, Ile, 0.746; Asn, Thr, Tyr, Lys, Leu, 0.746; Asn, Cit, Tyr, Lys, Leu, 0.746; Asn, Arg, Tyr, Val, Ile, 0.746; Asn, Orn, Lys, Ile, Phe, 0.746; Gly, Gln, His, Tyr, Val, 0.746; Gly, Gln, Arg, Tyr, Leu, 0.746; Gly, Gln, Ile, Leu, Phe, 0.746; Gly, Ala, Cit, Tyr, Ile, 0.746; Gln, Thr, Met, Lys, Ile, 0.746; Gln, Thr, Orn, Lys, Ile, 0.746; Gln, Thr, Orn, Leu, Phe, 0.746; Gln, Thr, Lys, Ile, Leu, 0.746; Ala, Tyr, Leu, Phe, 0.746; Gln, Ala, Ile, Leu, Trp, 0.746; Gln, Cit, Arg, Tyr, Ile, 0.746; Gln, Cit, Tyr, Val, Ile, 0.746; Tyr, Met, Ile, 0.746; Gln, Arg, Tyr, Ile, Trp, 0.746; Gln, Pro, Tyr, Lys, Ile, 0.746; Gln, Pro, Tyr, Ile, Trp, 0.746; Met, Leu, 0.746; Thr, Tyr, Met, Ile, Phe, 0.746; Ala, Cit, Tyr, Ile, Phe, 0.746; Cit, Arg, Pro, Tyr, Lys, 0.746; Ile, 0.746; Cit, Tyr, Orn, Lys, Ile, 0.746; Cit, Tyr, Orn, Ile, Trp, Cit, Tyr, Lys, Ile, Phe, 0.746; Ser, Asn, Gln, Leu, Phe, 0.745; Ser, Asn, His, Ile, Phe, 0.745; Ser, Gly, Gln, Tyr, Leu, 0.745; Ser, Gln, His, Thr, Ile, 0.745; Ser, Gln, His, Pro, Ile, 0.745; Ser, Gln, His, Ile, Leu, 0.745; Ser, Gln, His, Ile, Trp, 0.745; Cit, Tyr, Orn, Ile, 0.745; Ser, Tyr, Met, Leu, Phe, 0.745; Asn, Gly, Tyr, Val, Leu, 0.745; Asn, Gly, Tyr, Leu, Trp, 0.745; His, Orn, Lys, 0.745; Asn, His, Ala, Tyr, Ile, 0.745; Asn, His, Cit, Orn, Ile, 0.745; Asn, His, Pro, Lys, Ile, 0.745; Ile, Trp, 0.745; Asn, Thr, Cit, Tyr, Ile, 0.745; Asn, Thr, Tyr, Lys, Ile, 0.745; Asn, Thr, Lys, Ile, Phe, 0.745; Trp, 0.745; Asn, Pro, Lys, Ile, Phe, 0.745; Asn, Tyr, Lys, Ile, Leu, 0.745; Asn, Val, Met, Lys, Ile, 0.745; Gly, Gln, His, Thr, Ile, 0.745; Gly, Gln, Pro, Lys, Ile, 0.745; Gly, Gln, Lys, Ile, Leu, 0.745; Gly, Gln, Lys, Leu, Phe, 0.745; Gly, Cit, Pro, Tyr, Ile, 0.745; Gly, Cit, Tyr, Orn, Ile, 0.745; ln, His, Thr, Lys, Ile, 0.745; Gln, Ala, Cit, Arg, Ile, 0.745; Gln, Ala, Val, Lys, Ile, 0.745; Gln, Ala, Lys, Ile, Phe, 0.745; Cit, Val, Orn, Ile, 0.745; Gln, Tyr, Met, Lys, Leu, 0.745; Gln, Met, Lys, Ile, Leu, 0.745; Ala, Cit, Tyr, Val, Ile, 0.745; Met, Lys, Ile, 0.745; Cit, Arg, Tyr, Ile, Phe, 0.745; Cit, Tyr, Met, Ile, Phe, 0.745; Cit, Tyr, Orn, Ile, Phe, 0.745; Tyr, Leu, 0.745; Ser, Gln, His, Met, Ile, 0.745; Ser, Gln, His, Lys, Ile, 0.745; Ser, Gln, Pro, Tyr, Ile, 0.745; Ser, Cit, Tyr, Ile, Trp, 0.745; Ser, Arg, Orn, Lys, Ile, 0.745; Ser, Tyr, Met, Lys, Ile, 0.745; Asn, Gly, Pro, Tyr, Leu, Asn, Gly, Lys, Ile, Leu, 0.745; Asn, Gln, Ala, Tyr, Leu, 0.745; Asn, Gln, Cit, Pro, Ile, 0.745; Asn, Gln, Arg, Tyr, Leu, 0.745; Asn, Gln, Tyr, Met, Ile, 0.745; Asn, Gln, Val, Leu, Phe, 0.745; Asn, Gln, Met, Lys, Leu, 0.745; Asn, His, Pro, Ile, Phe, 0.745; His, Val, Met, Lys, 0.745; Asn, Thr, Pro, Lys, Ile, 0.745; Gly, Gln, Tyr, Val, Lys, 0.745; Gly, Gln, Orn, Lys, Leu, 0.745; Gly, Cit, Tyr, Lys, Ile, 0.745; Gln, His, Pro, Lys, Ile, 0.745; Lys, Ile, 0.745; Gln, His, Met, Lys, Ile, 0.745; Gln, His, Lys, Leu, Phe, 0.745; Gln, Thr, Arg, Tyr, Ile, 0

Gln, Thr, Tyr, Met, Ile, 0.745; Gln, Thr, Tyr, Ile, Trp, 0.745; Gln, Ala, Tyr, Met, Leu, 0.745; Gln, Cit, Val, Lys, Ile, 0.745 Gln, Cit, Met, Lys, Ile, 0.745; Gln, Arg, Tyr, Val, Lys, 0.745; Gln, Val, Orn, Leu, Phe, 0.745; Gln, Met, Orn, Lys, Ile, 0.745; , Cit, Tyr, Ile, Trp, 0.745; His, Arg, Tyr, Orn, Ile, 0.745; His, Arg, Lys, Ile, Trp, 0.745; Thr, Tyr, Orn, Leu, Phe, 0.745; , Met, Ile, Phe, 0.745; Ala, Tyr, Lys, Ile, Phe, 0.745; Arg, Orn, Lys, Ile, Trp, 0.745; Pro, Tyr, Met, Leu, Phe, 0.745; , Ile, Trp, 0.745; Tyr, Met, Ile, Phe, Trp, 0.745; Tyr, Lys, Ile, Phe, Trp, 0.745; Ser, Asn, His, Met, Ile, 0.744; Ser, Asn, Lys, Ile, Phe, 0.744; Ser, Gln, Ala, Tyr, Ile, 0.744; Ser, Gln, Orn, Lys, Ile, 0.744; Ser, Gln, Lys, Leu, Trp Ser, Ala, Arg, Lys, Ile, 0.744; Ser, Cit, Tyr, Ile, Phe, 0.744; Ser, Tyr, Met, Ile, Phe, 0.744; Asn, Gly, His, Val, Lys, 0.744 Asn, Gln, Arg, Ile, Leu, 0.744; Asn, Gln, Tyr, Val, Leu, 0.744; n, Gln, Val, Ile, Leu, 0.744; Asn, His, Thr, Met, Ile, 0.744; Asn, His, Ala, Orn, Ile, 0.744; Asn, His, Val, Lys, Ile, 0.744; Pro, Met, Lys, Ile, 0.744; Asn, Tyr, Met, Ile, Phe, 0.744; Gly, Gln, Cit, Arg, Ile, 0.744; Gly, Gln, Cit, Ile, Phe, 0.744; Tyr, Val, Trp, 0.744; Gly, Tyr, Met, Lys, Ile, 0.744; Gln, His, Ala, Leu, Trp, 0.744; Gln, His, Arg, Tyr, Val, 0.744; Orn, Phe, 0.744; Gln, Thr, Val, Leu, Phe, 0.744; Gln, Ala, Tyr, Met, Ile, 0.744; Gln, Ala, Lys, Leu, Phe, 0.744; Ile, 0.744; Gln, Cit, Tyr, Ile, Leu, 0.744; Gln, Arg, Tyr, Lys, Leu, 0.744; Gln, Tyr, Val, Met, Lys, 0.744; Gln, Orn, Lys, Ile, Leu, 0.744; His, Ala, Cit, Tyr, Ile, 0.744; His, Cit, Tyr, Orn, Ile, 0.744; His, Arg, Orn, Ile, Phe, 0.744; Ala, Arg, Met, Lys, Ile, 0.744; Arg, Tyr, Val, Met, Lys, 0.744; Ser, Gln, His, Val, Ile, 0.743; Ser, Cit, Tyr, Val, Ile, 0.743; Gly, Val, Lys, Ile, 0.743; Asn, Gln, Ala, Cit, Ile, 0.743; Asn, Val, Orn, Lys, Ile, 0.743; Gly, Gln, Tyr, Val, Met, 0.743; Gly, Tyr, Lys, Ile, Phe, 0.743; Gln, His, Pro, Orn, Ile, 0.743; Tyr, Ile, 0.743; Gln, Arg, Tyr, Orn, Ile, 0.743; Cit, Tyr, Ile, Phe, Trp, 0.743; Arg, Pro, Lys, Ile, Phe, 0.743; Pro, Tyr, Met, Lys, Ile, 0.743; Pro, Tyr, Lys, Ile, Phe, 0.743; Ser, Asn, His, Val, Lys, 0.743; Ser, Asn, Tyr, Met, Leu, 0.743; Ser, Gln, Cit, Tyr, Ile, 0.743; Ser, Gln, Tyr, Orn, Ile, 0.743; Ser, Gln, Lys, Ile, Leu, 0.743; Ser, His, Arg, Tyr, Ile, 0.743; Asn, Gly, Gln, Leu, Phe, 0.743; Asn, Gly, His, Tyr, Val, 0.743; Asn, Gly, Tyr, Met, Ile, 0.743; Asn, Gln, Ala, Tyr, Ile, 0.743; Gln, Ala, Ile, Leu, 0.743; Asn, Gln, Cit, Val, Ile, 0.743; Asn, Gln, Cit, Ile, Leu, 0.743; Asn, Gln, Arg, Leu, Phe, 0.743; Tyr, Orn, Ile, 0.743; Asn, His, Tyr, Lys, Leu, 0.743; Asn, His, Orn, Ile, Trp, 0.743; Asn, Arg, Orn, Lys, Leu, 0.743; Ile, Trp, 0.743; Gly, Tyr, Leu, Phe, Trp, 0.743; Gln, His, Pro, Tyr Gln, His, Tyr, Val, Met, 0.743; Gln, His, Tyr, Val, Phe, 0.743; Gln, His, Orn, Lys, Leu, 0.743; Gln, Thr, Cit, Lys, Ile Gln, Thr, Tyr, Lys, Ile, 0.743; Gln, Ala, Cit, Orn, Ile, 0.743; Gln, Cit, Val, Ile, Leu, 0.743; Gln, Cit, Orn, Ile, Leu, 0.743 Gln, Pro, Lys, Ile, Trp, 0.743; Gln, Tyr, Val, Met, Ile, 0.743; His, Arg, Met, Ile, Phe, 0.743; Thr, Cit, Tyr, Leu, Phe, 0.743; Arg, Tyr, Leu, Phe, Trp, 0.743; Pro, Tyr, Met, Ile, Phe, 0.743; Ser, Asn, His, Cit, Ile, 0.743; Ser, Gly Ser, Gln, Cit, Orn, Ile, 0.743; Asn, Gly, His, Met, Ile, 0.743; Asn, Gly, His, Orn, Ile, 0.743; Asn, Gly, Tyr Asn, Gln, Thr, Tyr, Ile, 0.743; Asn, His, Ala, Arg Asn, His, Val, Met, Ile, 0.743; Asn, Thr, Ala, Lys, Ile, 0.743; Asn, Ala, Orn, Lys, Ile, 0.743; Asn, Ala, Lys, Ile, Leu , 0.743; Asn, Arg, Pro, Tyr, Ile, 0.743; Asn, Pro, Orn, Lys, Ile, 0 Asn, Met, Lys, Ile, Trp, 0.743; Gly, Gln, Orn, Leu, Phe, 0.743; Gly, His, Arg, Ile, Phe, 0.743; Gly, Thr, Cit, Tyr, Ile, 0.743 Gly, Cit, Tyr, Ile, Leu, 0.743; Gln, His, Ala, Lys, Ile, 0.743; Gln, His, Tyr, Val, Lys, 0.743; Gln, His, Tyr, Lys, Phe, 0.743; , Thr, Cit, Ile, Leu, 0.743; Gln, Thr, Arg, Tyr, Leu, 0.743; Gln, Thr, Tyr, Leu, Trp, 0.743; Gln, Ala, Cit, Ile, Leu, 0.743; , Met, Lys, Ile, 0.743; Gln, Cit, Arg, Ile, Trp, 0.743; Gln, Cit, Pro, Lys, Ile, 0.743; Gln, Cit, Val, Ile, Phe, 0.743; , Leu, Trp, 0.743; Gln, Pro, Val, Lys, Ile, 0.743; Gln, Pro, Met, Lys, Ile, 0.743; Gln, Tyr, Orn, Ile, Trp, 0.743; His, Ala, Arg, Tyr, Ile, 0.743; His, Arg, Pro, Tyr, Ile, 0.743; His, Arg, Orn, Lys, Ile, 0.743; His, Tyr, Val, Ile, Phe Thr, Tyr, Met, Lys, Ile, 0.743; Ala, Cit, Tyr, Met, Ile, 0.743; Cit, Arg, Tyr, Ile, Trp, 0.743; Cit, Arg, Orn, Lys, Ile, 0.743 Cit, Tyr, Val, Ile, Trp, 0.743; Cit, Tyr, Met, Leu, Phe, 0.743; Pr o, Tyr, Ile, Leu, Phe, 0.743; Ser, Asn, Tyr, Val, Ile, 0.742; Ser, Asn, Val, Lys, Leu, 0.742; Ser, Gly, Gln, His, Ile, 0.742; Gln, Tyr, Met, Leu, 0.742; Ser, His, Cit, Tyr, Ile, 0.742; Ser, Tyr, Val, Ile, Phe, 0.742; Asn, Gly, Tyr, Val, Met, 0.742; Tyr, Val, Ile, 0.742; Asn, Gly, Lys, Ile, Phe, 0.742; Asn, Gly, Lys, Ile, Trp, 0.742; Asn, Gln, Val, Orn, Leu, 0.742; Leu, Phe, 0.742; Asn, Gln, Orn, Leu, Trp, 0.742; Asn, His, Thr, Cit, Ile, 0.742; Asn, His, Thr, Arg, Ile, 0.742; Phe, 0.742; Asn, His, Pro, Orn, Ile, 0.742; Asn, Arg, Tyr, Val, Lys, 0.742; Asn, Arg, Tyr, Met, Ile, 0.742; Asn, Tyr, Val, Lys, Ile, 0.742; Asn, Tyr, Met, Orn, Leu, 0.742; Asn, Val, Lys, Ile, Trp, 0.742; Asn, Orn, Lys, Leu, Phe, 0.742; Gly, Gln, Cit, Ile, Leu, 0.742; Gly, Gln, Cit, Ile, Trp, 0.742; Gly, Thr, Tyr, Leu, Phe, 0.742; Gly, Arg, Met, Lys, Ile, 0.742; His, Ala, Orn, Ile, 0.742; Gln, His, Ala, Lys, Phe, 0.742; Gln, His, Arg, Tyr, Leu, 0.742; Gln, His, Arg, Orn, Leu, 0.742; Gln, His, Tyr, Met, Phe, 0.742; Gln, Ala, Cit, Met, Ile, 0.742; Tyr, Ile, 0.742; Gln, Ala, Tyr, Val, Leu, 0.742; Gln, Ala, Tyr, Ile, Trp, 0.742; Gln, Cit, Tyr, Met, Ile, 0.742; Trp, 0.742; Gln, Arg, Pro, Lys, Ile, 0.742; Gln, Arg, Tyr, Val, Ile, 0.742; Gln, Pro, Ile, Leu, Phe, 0.742; His, Thr, Lys, Ile, Phe, 0.742; Thr, Tyr, Leu, Phe, Trp, 0.742; Ala, Cit, Pro, Tyr, Ile, 0.742; Ala, Cit, Tyr, Orn, Ile, 0.742; Ala, Arg, Pro, Tyr, Lys, 0.742; Cit, Tyr, Lys, Ile, Leu, 0.742; Arg, Met, Orn, Lys, Ile, 0.742; Ser, Asn, Lys, Ile, Leu, 0.742; Asn, Lys, Leu, Phe, 0.742; Ser, Gln, Thr, Leu, Phe, 0.742; Ser, Gln, Pro, Lys, Ile, 0.742; Asn, Gly, Gln, Val, Lys, 0.742; Tyr, Val, Lys, 0.742; Asn, Gln, His, Ala, Leu, 0.742; Asn, Gln, Thr, Ile, Leu, 0.742; Asn, Gln, Orn, Ile, Leu, 0.742; Ile, Leu, 0.742; Asn, His, Cit, Val, Lys, 0.742; Asn, His, Arg, Met Asn, His, Val, Lys, Trp, 0.742; Asn, Ala, Tyr, Lys, Leu, 0.742; Asn, Cit, Tyr, Met, Leu, 0.742; Asn, Arg, Tyr, Ile, Phe Asn, Pro, Tyr, Lys, Ile, 0.742; Asn, Tyr, Met, Leu, Trp, 0.742; Gly, Gln, His, Pro, Tyr, 0.742; Gly, Gln, His, Orn, Leu, 0.742 Gly, Gln, Cit, Val, Ile, 0.742; Gly, Gln, Val, Orn, Leu, 0.742; Gly, Gln, Orn, Ile, Leu, 0.742; Gly, Cit, Arg, Tyr, Ile, 0.742; , Tyr, Met, Ile, Phe, 0.742; Gly, Tyr, Ile, Leu, Phe, 0.742; Gln, His, Tyr, Met, Orn, 0.742; Gln, His, Tyr, Phe, Trp, 0.742; , Cit, Orn, Ile, 0.742; Gln, Thr, Orn, Ile, Leu, 0.742; Gln, Thr, Ile, Leu, Phe, 0.742; Gln, Ala, Orn, Lys, Ile, 0.742; , Ile, Phe, 0.742; Gln, Cit, Pro, Met, Ile, 0.742; Gln, Cit, Pro, Ile, Trp, 0.742; Gln, Cit, Met, Orn, Ile, 0.742; , Ile, 0.742; Gln, Lys, Leu, Phe, Trp, 0.742; His, Cit, Pro, Tyr, Ile, 0.742; Cit, Arg, Lys, Ile, Trp, 0.742; , 0.742; Cit, Tyr, Met, Ile, Trp, 0.742; Arg, Val, Orn, Lys, Ile, 0 Ser, Gln, His, Orn, Leu, 0.741; Ser, Gln, Cit, Tyr, Leu, 0.741; Ser, Gln, Tyr, Val, Leu, 0.741; Ser, Tyr, Ile, Leu, Phe, 0.741; Asn, Gly, His, Ala, Ile, 0.741; Asn, Gly, Lys, Leu, Phe, 0.741; Asn, Gln, Thr, Orn, Leu, 0.741; , Gln, Cit, Ile, Phe, 0.741; Asn, Gln, Cit, Leu, Phe, 0.741; Asn, Gln, Pro, Orn, Ile, 0.741; Asn, His, Thr, Tyr, Ile, 0.741; , Arg, Tyr, Lys, 0.741; Asn, His, Arg, Val, Ile, 0.741; Asn, His, Arg, Ile, Trp, 0.741; Asn, His, Pro, Val, Ile, 0.741; , Ile, Trp, 0.741; Asn, His, Met, Ile, Leu, 0.741; Asn, Arg, Val, Orn, Lys, 0.741; Asn, Tyr, Val, Ile, Leu, 0.741; , Phe, 0.741; Gly, Gln, Cit, Met, Ile, 0.741; Gly, Gln, Arg, Tyr, Val, 0.741; Gly, Gln, Arg, Leu, Phe, 0.741; Gly, His, Lys, Ile, Phe, 0.741; Gly, Arg, Tyr, Val, Lys, 0.741; Gly, Tyr, Met, Ile, Leu, 0.741; Gln, His, Ala, Tyr, Lys, 0.741 Gln, His, Arg, Tyr, Phe, 0.741; Gln, His, Pro, Tyr, Lys, 0.741; n, Thr, Ala, Lys, Ile, 0.741; Gln, Thr, Arg, Orn, Ile, 0.741; Gln, Thr, Leu, Phe, Trp, 0.741; Gln, Ala, Cit, Pro, Ile, 0.741; Cit, Arg, Ile, Leu, 0.741; Gln, Cit, Pro, Ile, Leu, 0.741; Gln, Cit, Tyr, Val, Leu, 0.741; Gln, Arg, Orn, Leu, Phe, 0.741; Lys, Leu, Phe, 0.741; Gln, Pro, Orn, Lys, Ile, 0.741; Gln, Tyr, Val, Orn, Leu, 0.741; Gln, Tyr, Val, Lys, Phe, 0.741; Ile, Phe, 0.741; His, Thr, Tyr, Leu, Phe, 0.741; Thr, Cit, Tyr, Met, Ile, 0.741; Thr, Cit, Tyr, Orn, Ile, 0.741; Phe, 0.741; Thr, Arg, Lys, Ile, Leu, 0.741; Cit, Tyr, Val, Ile, Phe, 0.741; Arg, Pro, Tyr, Met, Lys, 0.741; Tyr, Val, Ile, Leu, Phe, 0.741; Tyr, Met, Lys, Leu, Phe, 0.741; Tyr, Met, Ile, Leu, Trp, 0.741; Tyr, Orn, Lys, Ile, Phe, 0.741; Ser, Asn, Gln, Thr, Leu, 0.74; Ser, Asn, Gln, Val, Lys, 0.74; Ser, Asn, His, Ala, Ile, 0.74; Ser, Gln, Ala, Tyr, Leu, 0.74; Gln, Orn, Leu, Phe, 0.74; Ser, Thr, Arg, Lys, Ile, 0.74; Ser, Tyr, Lys, I le, Phe, 0.74; Asn, Gly, Gln, Ile, Leu, 0.74; Asn, Gly, His, Arg, Ile, 0.74; Asn, Gly, Pro, Lys, Ile, 0.74; Phe, 0.74; Asn, Gln, His, Val, Lys, 0.74; Asn, Gln, Thr, Val, Lys, 0.74; Asn, Gln, Pro, Ile, Phe, 0.74;

Met, Orn, Leu, 0.74; Asn, Gln, Met, Ile, Leu, 0.74; Asn, His, Thr, Val, Ile, 0.74; Asn, His, Cit, Ile, Leu, 0.74; Pro, Ile, 0.74; Asn, Thr, Pro, Tyr, Leu, 0.74; Asn, Ala, Arg, Tyr, Ile, 0.74; Asn, Ala, Tyr, Val, Ile, 0.74; Ile, 0.74; Asn, Ala, Tyr, Ile, Leu, 0.74; Asn, Cit, Ile, Leu, Phe, 0.74; Asn, Pro, Tyr, Met, Leu, 0.74; Asn, Pro, Val, Lys, Ile, 0.74; Asn, Tyr, Val, Met, Leu, 0.74; Asn, Tyr, Val, Lys, Leu, 0.74; Asn, Tyr, Orn, Lys, Ile, 0.74; Asn, Tyr, Lys, Ile, Trp, 0.74; Asn, Met, Lys, Leu, Phe, 0.74; Gly, Gln, His, Tyr, Lys, 0.74; Gly, Gln, His, Leu, Phe, 0.74; Gln, Ala, Tyr, Val, 0.74; Gly, Gln, Orn, Leu, Trp, 0.74; Gly, Gln, Lys, Leu, Trp, 0.74; Gly, Arg, Orn, Lys, Ile, 0.74; Thr, Tyr, Leu, 0.74; Gln, His, Ala, Orn, Leu, 0.74; Gln, His, Tyr, Lys, Trp, 0.74; Gln, Thr, Lys, Leu, Trp, 0.74; Ile, Leu, 0.74; Gln, Cit, Pro, Ile, Phe, 0.74; Gln, Cit, Met, Ile, Trp, 0.74; Gln, Arg, Tyr, Met Gln, Pro, Orn, Ile, Leu, 0.74; Gln, Pro, Lys, Ile, Phe, 0.74; Gln, Val, Orn, Ile, Leu, 0.74; His, Cit, Tyr, Ile, Leu , 0.74; His, Tyr, Met, Leu, Phe, 0.74; Thr, Arg, Orn, Lys, Ile, 0.74; Ala, Tyr, Ile, Leu, Phe, 0.74; Cit, Tyr, Val, Lys, Ile, 0.74; Arg, Tyr, Met, Leu, Phe, 0.74; Arg, Lys, Ile, Leu, Trp, 0.74; Tyr, Met, Orn, Lys, Ile, 0.74; , Orn, Leu, Phe, Trp, 0.74; Tyr, Lys, Leu, Phe, Trp, 0.74
［５．アミノ酸を含む６変数の式］
Gln, His, Tyr, Ile, Phe, Trp, 0.785; Asn, Gly, Gln, Tyr, Leu, Phe, 0.78; Gln, His, Arg, Tyr, Ile, Phe, 0.78; Asn, Gln, His, Cit, Orn, Ile, 0.78; Gln, His, Tyr, Met, Ile, Phe, 0.78; Asn, Arg, Tyr, Lys, Ile, Phe, 0.779; Asn, Gly, Arg, Tyr, Lys, Ile, 0.778; Asn, Arg, Tyr, Met, Lys, Ile, 0.778; Gln, His, Tyr, Orn, Ile, Phe, 0.778; Gln, His, Tyr, Ile, Leu, Phe, 0.778; Arg, Tyr, Met, Lys, Ile, Phe, 0.778; His, Arg, Tyr, Lys, Ile, Phe, 0.778; Asn, Gln, His, Tyr, Ile, Trp, 0.777; Gly, Arg, Tyr, Lys, Ile, Phe, 0.777; Arg, Tyr, Lys, Ile, Phe, Trp, 0.777; Ser, Gln, His, Tyr, Ile, Phe, 0.777; Asn, Gln, His, Tyr, Ile, Phe, 0.777; Gln, His, Ala, Tyr, Ile, Phe, 0.777; Gln, His, Tyr, Val, Ile, Phe, 0.777; Gln, Tyr, Lys, Ile, Leu, Phe, 0.777; Arg, Tyr, Lys, Ile, Leu, Phe, 0.777; Ser, Gln, His, Tyr, Ile, Trp, 0.776; Gly, Gln, His, Tyr, Met, Ile, 0.776; Gly, Gln, His, Tyr, Ile, Phe, 0.776; Arg, Tyr, Orn, Lys, Ile, Phe, 0.776; Asn, Gly, Gln, His, Tyr, Ile, 0.775; Gly, Gln, His, Tyr, Ile, Trp, 0.775; Gly, Gln, Tyr, Ile, Leu, Phe, 0.775; Gln, Tyr, Ile, Leu, Phe, Trp, 0.775; Ser, Asn, Gln, His, Tyr, Ile, 0.775; Ser, Arg, Tyr, Lys, Ile, Phe, 0.775; Asn, Gln, His, Cit, Ile, Phe, 0.775; Asn, Gln, His, Lys, Ile, Phe, 0.775; Gln, His, Thr, Tyr, Ile, Phe, 0.775; Gln, His, Cit, Orn, Ile, Phe, 0.775; Gln, His, Pro, Tyr, Ile, Phe, 0.775; Gln, His, Tyr, Lys, Ile, Phe, 0.775; Arg, Tyr, Val, Lys, Ile, Phe, 0.775; Asn, Gln, His, Tyr, Met, Ile, 0.774; Gln, His, Tyr, Leu, Phe, Trp, 0.774; Arg, Tyr, Met, Lys, Ile, Trp, 0.774; Ser, Asn, Arg, Tyr, Lys, Ile, 0.773; Asn, Cit, Arg, Tyr, Lys, Ile, 0.773; Asn, Arg, Tyr, Lys, Ile, Trp, 0.773; Gln, His, Cit, Tyr, Ile, Phe, 0.773; Asn, Gln, Arg, Tyr, Lys, Ile, 0.773; Asn, Gln, Tyr, Ile, Leu, Phe, 0.773; Asn, His, Arg, Tyr, Lys, Ile, 0.773; Gly, Arg, Tyr, Met, Lys, Ile, 0.773; Gln, His, Arg, Tyr, Orn, Ile, 0.772; Gln, Pro, Tyr, Lys, Ile, Phe, 0.772; Gln, Tyr, Met, Lys, Ile, Phe, 0.772; His, Tyr, Met, Lys, Ile, Phe, 0.772; Ser, Gln, Tyr, Lys, Ile, Phe, 0.771; Asn, Gln, His, Tyr, Orn, Ile, 0.771; Asn, Gln, His, Val, Ile, Phe, 0.771; Gly, Gln, Arg, Tyr, Lys, Ile, 0.771; Gly, Gln, Tyr, Leu, Phe, Trp, 0.771; Thr, Arg, Tyr, Lys, Ile, Phe, 0.771; Asn, Gln, His, Thr, Tyr, Ile, 0.771; Asn, Gln, His, Ala, Cit, Ile, 0.771; Asn, Gln, His, Cit, Arg, Ile, 0.771; Asn, Gln, Tyr, Lys, Ile, Phe, 0.771; Gly, Gln, His, Tyr, Leu, Phe, 0.771; Gln, His, Cit, Tyr, Orn, Ile, 0.771; Gln, His, Cit, Tyr, Ile, Trp, 0.771; Gln, Arg, Tyr, Ile, Leu, Phe, 0.771; Ser, Gln, Tyr, Met, Ile, Phe, 0.77; Asn, Gln, His, Cit, Pro, Ile, 0.77; Asn, Gln, His, Arg, Ile, Phe, 0.77; Asn, Gln, His, Pro, Tyr, Ile, 0.77; Asn, Gln, His, Tyr, Ile, Leu, 0.77; Gln, His, Ala, Tyr, Ile, Trp, 0.77; Gln, His, Cit, Arg, Ile, Phe, 0.77; Gln, His, Cit, Pro, Orn, Ile, 0.77; Gln, Cit, Tyr, Ile, Leu, Phe, 0.77; Gln, Arg, Tyr, Lys, Ile, Phe, 0.77; Ala, Arg, Tyr, Lys, Ile, Phe, 0.77; Cit, Arg, Tyr, Lys, Ile, Phe, 0.77; Ser, Gln, Tyr, Ile, Leu, Phe, 0.77; Asn, Gln, His, Cit, Ile, Trp, 0.77; Asn, Gln, His, Arg, Tyr, Ile, 0.77; Asn, Gln, His, Met, Ile, Phe, 0.77; Asn, Gln, Arg, Orn, Lys, Ile, 0.77; Asn, Arg, Tyr, Val, Lys, Ile, 0.77; Asn, Arg, Tyr, Orn, Lys, Ile, 0.77; Gly, Gln, His, Cit, Ile, Phe, 0.77; Gly, Gln, Tyr, Met, Ile, Phe, 0.77; Gln, His, Thr, Tyr, Orn, Ile, 0.77; Gln, His, Cit, Ile, Leu, Phe, 0.77; Gln, His, Arg, Tyr, Ile, Trp, 0.77; Gln, His, Tyr, Met, Ile, Trp, 0.77; Gln, His, Tyr, Orn, Ile, Trp, 0.77; Gln, His, Tyr, Orn, Leu, Phe, 0.77; Gln, His, Tyr, Ile, Leu, Trp, 0.77; Gln, Pro, Tyr, Ile, Leu, Phe, 0.77; Gln, Tyr, Val, Lys, Ile, Phe, 0.77; Asn, Gln, His, Ala, Tyr, Ile, 0.769; Asn, Gln, His, Tyr, Val, Ile, 0.769; Asn, Gln, His, Ile, Leu, Phe, 0.769; Asn, Gln, His, Ile, Phe, Trp, 0.769; Asn, Ala, Arg, Tyr, Lys, Ile, 0.769; Asn, Arg, Tyr, Lys, Ile, Leu, 0.769; Gly, Gln, His, Tyr, Val, Trp, 0.769; Gly, Gln, Tyr, Met, Leu, Phe, 0.769; Gln, His, Ala, Arg, Tyr, Ile, 0.769; Gln, His, Cit, Val, Orn, Ile, 0.769; Gln, His, Cit, Orn, Ile, Leu, 0.769; Gln, Tyr, Lys, Leu, Phe, Trp, 0.769; Ser, Gln, His, Tyr, Met, Ile, 0.768; Asn, Gly, Gln, Cit, Tyr, Ile, 0.768; Asn, Gly, Gln, Tyr, Lys, Leu, 0.768; Asn, Gly, Cit, Tyr, Ile, Leu, 0.768; Asn, Gln, His, Orn, Ile, Phe, 0.768; Asn, Thr, Arg, Tyr, Lys, Ile, 0.768; Asn, Arg, Pro, Tyr, Lys, Ile, 0.768; Gln, His, Cit, Pro, Ile, Phe, 0.768; Gln, His, Cit, Ile, Phe, Trp, 0.768; Gln, Tyr, Val, Ile, Phe, Trp, 0.768; Gln, Tyr, Orn, Ile, Leu, Phe, 0.768; Ser, Gln, His, Cit, Orn, Ile, 0.768; Ser, Gln, Tyr, Ile, Phe, Trp, 0.768; Asn, Gly, Gln, His, Tyr, Leu, 0.768; Asn, Gly, Arg, Tyr, Lys, Leu, 0.768; Asn, Gln, His, Cit, Val, Ile, 0.768; Asn, Gln, His, Val, Lys, Ile, 0.768; Asn, Gln, Arg, Lys, Ile, Phe, 0.768; Asn, Gln, Tyr, Leu, Phe, Trp, 0.768; Asn, His, Arg, Lys, Ile, Phe, 0.768; Asn, Cit, Tyr, Met, Lys, Ile, 0.768; Asn, Cit, Tyr, Lys, Ile, Trp, 0.768; Gly, Gln, His, Cit, Orn, Ile, 0.768; Gly, Gln, Tyr, Val, Leu, Phe, 0.768; Gly, Gln, Tyr, Met, Lys, Ile, 0.768; Gln, His, Cit, Pro, Val, Ile, 0.768; Gln, His, Cit, Val, Ile, Phe, 0.768; Gln, His, Arg, Lys, Ile, Phe, 0.768; His, Arg, Tyr, Met, Lys, Ile, 0.768; Ser, Asn, Gln, Tyr, Leu, Phe, 0.767; Ser, Gln, Arg, Tyr, Lys, Ile, 0.767; Asn, Gln, His, Thr, Ile, Phe, 0.767; Asn, Gln, His, Ala, Ile, Trp, 0.767; Asn, Gln, His, Pro, Val, Ile, 0.767; Asn, Gln, Tyr, Met, Leu, Phe, 0.767; Asn, Gln, Tyr, Lys, Leu, Phe, 0.767; Asn, His, Tyr, Met, Lys, Ile, 0.767; Gly, Gln, Pro, Tyr, Leu, Phe, 0.767; Gln, His, Ala, Tyr, Orn, Ile, 0.767; Gln, His, Cit, Arg, Orn, Ile, 0.767; Gln, His, Cit, Met, Orn, Ile, 0.767; Gln, His, Arg, Pro, Tyr, Ile, 0.767; Gln, His, Tyr, Met, Orn, Ile, 0.767; Gln, Tyr, Val, Ile, Leu, Phe, 0.767; Gln, Tyr, Met, Ile, Leu, Phe, 0.767; Ser, Gln, Tyr, Orn, Ile, Phe, 0.766; Asn, Gly, Gln, His, Cit, Ile, 0.766; Asn, Gly, Gln, His, Ile, Phe, 0.766; Asn, Gly, Gln, Lys, Ile, Leu, 0.766; Asn, Gly, His, Tyr, Met, Ile, 0.766; Asn, Gln, His, Pro, Ile, Phe, 0.766; Asn, Gln, Cit, Tyr, Leu, Phe, 0.766; Asn, Cit, Tyr, Ile, Leu, Phe, 0.766; Gly, Gln, Thr, Tyr, Leu, Phe, 0.766; Gly, Gln, Ala, Tyr, Ile, Phe, 0.766; Gly, Gln, Pro, Tyr, Ile, Phe, 0.766; Gly, Gln, Tyr, Lys, Ile, Phe, 0.766; Gly, Gln, Tyr, Lys, Leu, Phe, 0.766; Gln, His, Thr, Arg, Tyr, Ile, 0.766; Gln, His, Ala, Cit, Pro, Ile, 0.766; Gln, His, Cit, Met, Ile, Phe, 0.766; Gln, His, Tyr, Val, Ile, Trp, 0.766; Gln, Thr, Tyr, Lys, Ile, Phe, 0.766; Gln, Arg, Tyr, Lys, Leu, Phe, 0.766; Ser, Gln, Pro, Tyr, Ile, Phe, 0.766; Ser, Gln, Tyr, Met, Lys, Ile, 0.766; Asn, Gly, Arg, Orn, Lys, Ile, 0.766; Asn, Gln, His, Thr, Ala, Ile, 0.766; Asn, Gln, His, Ala, Val, Ile, 0.766; Asn, Gln, His, Ala, Orn, Ile, 0.766; Asn, Gln, His, Ala, Ile, Leu, 0.766; Asn, Gln, His, Arg, Lys, Ile, 0.766; Asn, Gln, His, Val, Ile, Leu, 0.766; Asn, Gln, Tyr, Orn, Leu, Phe, 0.766; Asn, Cit, Tyr, Lys, Ile, Leu, 0.766; Gly, Gln, His, Arg, Tyr, Ile, 0.766; Gly, Cit, Arg, Tyr, Lys, Ile, 0.766; Gly, Arg, Tyr, Val, Lys, Ile, 0.766; Gln, His, Thr, Tyr, Ile, Trp, 0.766; Gln, His, Cit, Arg, Pro, Ile, 0.766; Gln, His, Cit, Pro, Ile, Leu, 0.766; Gln, His, Arg, Orn, Ile, Phe, 0.766; Gln, His, Tyr, Lys, Leu, Phe, 0.766; Gln, Arg, Tyr, Met, Lys, Ile, 0.766; Gln, Arg, Orn, Lys, Ile, Trp, 0.766; Gln, Arg, Lys, Ile, Leu, Phe, 0.766; Gln, Pro, Tyr, Lys, Leu, Phe, 0.766; His, Arg, Tyr, Met, Ile, Phe, 0.766; Cit, Arg, Tyr, Orn, Lys, Ile, 0.766; Arg, Pro, Tyr, Lys, Ile, Phe, 0.766; Ser, Asn, Gln, Tyr, Ile, Leu, 0.765; Ser, Gln, His, Arg, Tyr, Ile, 0.765; Ser, Gln, Thr, Tyr, Ile, Phe, 0.765; Ser, His, Arg, Tyr, Lys, Ile, 0.765; Ser, Arg, Tyr, Lys, Ile, Trp, 0.765; Asn, Gly, Gln, Tyr, Ile, Leu, 0.765; Asn, Gly, Gln, Tyr, Leu, Trp, 0.765; Asn, Gly, Arg, Lys, Ile, Phe, 0.765; Asn, Gln, His, Ala, Pro, Ile, 0.765; Asn, Gln, His, Cit, Ile, Leu, 0.765; Asn, Gln, His, Tyr, Leu, Phe, 0.765; Asn, Gln, Cit, Tyr, Lys, Ile, 0.765; Asn, Gln, Arg, Lys, Ile, Trp, 0.765; Asn, Gln, Tyr, Val, Leu, Phe, 0.765; Asn, Gln, Tyr, Ile, Leu, Trp, 0.765; Asn, His, Cit, Tyr, Met, Ile, 0.765; Gly, Gln, Tyr, Orn, Leu, Phe, 0.765; Gly, Gln, Tyr, Ile, Phe, Trp, 0.765; Gly, His, Arg, Tyr, Lys, Ile, 0.765; Gln, His, Thr, Cit, Orn, Ile, 0.765; Gln, His, Cit, Orn, Ile, Trp, 0.765; Gln, His, Arg, Tyr, Val, Ile, 0.765; Gln, His, Pro, Tyr, Leu, Phe, 0.765; Gln, Thr, Tyr, Ile, Leu, Phe, 0.765; Gln, Arg, Met, Lys, Ile, Trp, 0.765; Gln, Arg, Lys, Ile, Phe, Trp, 0.765; Gln, Pro, Tyr, Ile, Phe, Trp, 0.765; Gln, Tyr, Orn, Leu, Phe, Trp, 0.765; His, Thr, Cit, Tyr, Ile, Phe, 0.765; Ser, Asn, Gln, His, Orn, Ile, 0.764; Ser, Asn, Gln, His, Ile, Phe, 0.764; Ser, Gly, Gln, Tyr, Ile, Phe, 0.764; Asn, Gly, Gln, Tyr, Lys, Ile, 0.764; Asn, Gln, His, Thr, Cit, Ile, 0.764; Asn, Gln, His, Cit, Met, Ile, 0.764; Asn, Gln, His, Arg, Val, Ile, 0.764; Asn, Gln, His, Val, Orn, Ile, 0.764; Asn, His, Cit, Tyr, Orn, Ile, 0.764; Gly, Gln, His, Cit, Tyr, Ile, 0.764; Gly, Gln, Tyr, Lys, Ile, Leu, 0.764; Gly, Gln, Tyr, Lys, Leu, Trp, 0.764; Gln, His, Thr, Cit, Pro, Ile, 0.764; Gln, His, Ala, Cit, Tyr, Ile, 0.764; Gln, His, Cit, Pro, Ile, Trp, 0.764; Gln, His, Arg, Pro, Ile, Phe, 0.764; Gln, His, Arg, Ile, Phe, Trp, 0.764; Gln, His, Pro, Tyr, Ile, Trp, 0.764; Gln, His, Tyr, Met, Leu, Phe, 0.764; Gln, His, Ile, Leu, Phe, Trp, 0.764; Gln, Thr, Arg, Lys, Ile, Trp, 0.764; Gln, Arg, Val, Lys, Ile, Phe, 0.764; Gln, Pro, Tyr, Leu, Phe, Trp, 0.764; Gln, Tyr, Met, Orn, Leu, Phe, 0.764; His, Arg, Tyr, Orn, Ile, Phe, 0.764; Ser, Asn, Gln, Tyr, Lys, Ile, 0.764; Ser, Arg, Tyr, Met, Lys, Ile, 0.764; Asn, Gly, Cit, Pro, Tyr, Ile, 0.764; Asn, Gln, His, Thr, Orn, Ile, 0.764; Asn, Gln, His, Cit, Tyr, Ile, 0.764; Asn, Gln, His, Val, Met, Ile, 0.764; Asn, Gln, Ala, Arg, Lys, Ile, 0.764; Asn, Gln, Tyr, Orn, Ile, Phe, 0.764; Asn, Gln, Val, Lys, Ile, Leu, 0.764; Asn, Cit, Tyr, Orn, Lys, Ile, 0.764; Asn, Arg, Tyr, Lys, Leu, Phe, 0.764; Gly, Gln, His, Arg, Ile, Phe, 0.764; Gly, Gln, His, Tyr, Leu, Trp, 0.764; Gly, Gln, Cit, Tyr, Ile, Leu, 0.764; Gly, Gln, Arg, Lys, Ile, Phe, 0.764; Gly, Ala, Arg, Tyr, Lys, Ile, 0.764; Gly, Arg, Tyr, Orn, Lys, Ile, 0.764; Gln, His, Thr, Cit, Val, Ile, 0.764; Gln, His, Thr, Tyr, Met, Ile, 0.764; Gln, His, Ala, Cit, Orn, Ile, 0.764; Gln, His, Ala, Tyr, Val, Ile, 0.764; Gln, His, Ala, Tyr, Met, Ile, 0.764; Gln, His, Cit, Pro, Tyr, Ile, 0.764; Gln, His, Arg, Val, Ile, Phe, 0.764; Gln, His, Pro, Tyr, Met, I

le, 0.764; Gln, His, Tyr, Val, Orn, Ile, 0.764; Gln, His, Tyr, Orn, Ile, Leu, 0.764; Gln, His, Val, Ile, Leu, Phe, 0.764; Gln, Cit, Tyr, Lys, Ile, Phe, 0.764; Gln, Arg, Orn, Lys, Ile, Phe, 0.764; Gln, Tyr, Met, Lys, Ile, Leu, 0.764; His, Thr, Tyr, Met, Ile, Phe, 0.764; His, Ala, Tyr, Met, Ile, Phe, 0.764; His, Arg, Tyr, Orn, Lys, Ile, 0.764; His, Pro, Tyr, Met, Lys, Ile, 0.764; Ser, Asn, Gln, Lys, Leu, Phe, 0.763; Ser, Asn, Cit, Tyr, Lys, Ile, 0.763; Ser, Asn, Arg, Lys, Ile, Leu, 0.763; Ser, Asn, Arg, Lys, Ile, Phe, 0.763; Ser, Gln, His, Ala, Tyr, Ile, 0.763; Ser, Gln, His, Tyr, Orn, Ile, 0.763; Ser, Gln, Arg, Lys, Ile, Trp, 0.763; Ser, Gln, Tyr, Val, Ile, Phe, 0.763; Ser, Gln, Tyr, Lys, Ile, Trp, 0.763; Ser, Arg, Tyr, Val, Lys, Ile, 0.763; Ser, Arg, Tyr, Orn, Lys, Ile, 0.763; Asn, Gly, Arg, Lys, Ile, Leu, 0.763; Asn, Gly, Tyr, Met, Lys, Leu, 0.763; Asn, Gln, His, Ala, Arg, Ile, 0.763; Asn, Gln, His, Tyr, Orn, Leu, 0.763; Asn, Gln, His, Tyr, Lys, Ile, 0.763; Asn, Gln, Tyr, Met, Lys, Ile, 0.763; Asn, Gln, Tyr, Lys, Ile, Leu, 0.763; Asn, Gln, Tyr, Ile, Phe, Trp, 0.763; Asn, Gln, Lys, Ile, Leu, Phe, 0.763; Asn, His, Thr, Lys, Ile, Phe, 0.763; Asn, Cit, Tyr, Lys, Ile, Phe, 0.763; Asn, Tyr, Met, Lys, Ile, Leu, 0.763; Gly, Gln, Thr, Tyr, Ile, Phe, 0.763; Gly, Gln, Arg, Lys, Ile, Trp, 0.763; Gly, Gln, Tyr, Lys, Ile, Trp, 0.763; Gly, Thr, Arg, Tyr, Lys, Ile, 0.763; Gly, Arg, Tyr, Lys, Ile, Leu, 0.763; Gln, His, Thr, Cit, Ile, Phe, 0.763; Gln, His, Ala, Cit, Arg, Ile, 0.763; Gln, His, Cit, Met, Ile, Trp, 0.763; Gln, His, Arg, Tyr, Ile, Leu, 0.763; Gln, His, Arg, Ile, Leu, Phe, 0.763; Gln, His, Pro, Tyr, Orn, Ile, 0.763; Gln, His, Tyr, Val, Ile, Leu, 0.763; Gln, His, Val, Ile, Phe, Trp, 0.763; Gln, Cit, Arg, Lys, Ile, Phe, 0.763; Gln, Cit, Tyr, Orn, Ile, Phe, 0.763; Gln, Cit, Tyr, Leu, Phe, Trp, 0.763; Gln, Arg, Lys, Ile, Leu, Trp, 0.763; Gln, Tyr, Lys, Ile, Phe, Trp, 0.763; His, Cit, Arg, Tyr, Ile, Phe, 0.763; His, Tyr, Met, Ile, Phe, Trp, 0.763; Ala, Arg, Tyr, Met, Lys, Ile, 0.763; Arg, Pro, Tyr, Met, Lys, Ile, 0.763; Arg, Tyr, Met, Orn, Lys, Ile, 0.763; Ser, Asn, Gly, Cit, Tyr, Ile, 0.763; Ser, Gln, Ala, Tyr, Ile, Phe, 0.763; Ser, Gln, Arg, Val, Lys, Ile, 0.763; Ser, Gln, Arg, Lys, Ile, Phe, 0.763; Ser, Gln, Tyr, Leu, Phe, Trp, 0.763; Ser, Thr, Arg, Tyr, Lys, Ile, 0.763; Ser, Arg, Tyr, Lys, Ile, Leu, 0.763; Asn, Gly, Gln, His, Val, Ile, 0.763; Asn, Gly, Gln, Thr, Lys, Leu, 0.763; Asn, Gly, Gln, Ala, Tyr, Ile, 0.763; Asn, Gly, Gln, Lys, Leu, Phe, 0.763; Asn, Gly, Cit, Lys, Ile, Leu, 0.763; Asn, Gln, His, Thr, Val, Ile, 0.763; Asn, Gln, His, Ala, Ile, Phe, 0.763; Asn, Gln, Thr, Tyr, Leu, Phe, 0.763; Asn, Gln, Arg, Tyr, Leu, Phe, 0.763; Asn, Gln, Tyr, Lys, Leu, Trp, 0.763; Asn, Thr, Arg, Lys, Ile, Phe, 0.763; Asn, Ala, Cit, Tyr, Lys, Ile, 0.763; Asn, Arg, Orn, Lys, Ile, Phe, 0.763; Gly, Gln, His, Pro, Tyr, Ile, 0.763; Gly, Gln, Cit, Pro, Orn, Ile, 0.763; Gly, Gln, Cit, Tyr, Ile, Phe, 0.763; Gly, Gln, Pro, Tyr, Leu, Trp, 0.763; Gly, Gln, Tyr, Met, Ile, Leu, 0.763; Gln, His, Ala, Cit, Ile, Phe, 0.763; Gln, His, Ala, Pro, Tyr, Ile, 0.763; Gln, His, Cit, Tyr, Ile, Leu, 0.763; Gln, Thr, Arg, Lys, Ile, Phe, 0.763; Gln, Ala, Tyr, Met, Ile, Phe, 0.763; Gln, Cit, Arg, Orn, Lys, Ile, 0.763; Gln, Arg, Tyr, Lys, Ile, Trp, 0.763; Gln, Pro, Tyr, Ile, Leu, Trp, 0.763; Gln, Tyr, Val, Leu, Phe, Trp, 0.763; His, Thr, Tyr, Lys, Ile, Phe, 0.763; His, Ala, Tyr, Met, Lys, Ile, 0.763; His, Tyr, Met, Orn, Lys, Ile, 0.763; Arg, Tyr, Val, Met, Lys, Ile, 0.763; Arg, Tyr, Val, Lys, Ile, Trp, 0.763; Ser, Asn, Gln, Tyr, Ile, Phe, 0.762; Ser, Gly, Gln, Tyr, Leu, Phe, 0.762; Ser, Gly, Arg, Tyr, Lys, Ile, 0.762; Ser, Gln, His, Cit, Ile, Phe, 0.762; Ser, Gln, Ala, Arg, Lys, Ile, 0.762; Ser, Arg, Pro, Tyr, Lys, Ile, 0.762; Asn, Gly, Gln, His, Orn, Ile, 0.762; Asn, Gly, Gln, His, Lys, Ile, 0.762; Asn, Gly, Gln, Cit, Tyr, Leu, 0.762; Asn, Gly, Gln, Tyr, Ile, Trp, 0.762; Asn, Gly, His, Cit, Tyr, Ile, 0.762; Asn, Gly, Cit, Tyr, Val, Ile, 0.762; Asn, Gly, Cit, Tyr, Met, Ile, 0.762; Asn, Gly, Cit, Tyr, Orn, Ile, 0.762; Asn, Gln, His, Arg, Ile, Leu, 0.762; Asn, Gln, His, Tyr, Val, Orn, 0.762; Asn, Gln, Thr, Arg, Lys, Ile, 0.762; Asn, Gln, Thr, Lys, Leu, Phe, 0.762; Asn, Gln, Arg, Tyr, Ile, Leu, 0.762; Asn, Gln, Arg, Val, Lys, Ile, 0.762; Asn, Gln, Arg, Lys, Ile, Leu, 0.762; Asn, Gln, Val, Lys, Ile, Phe, 0.762; Asn, His, Ala, Cit, Tyr, Ile, 0.762; Asn, His, Cit, Pro, Tyr, Ile, 0.762; Asn, His, Arg, Tyr, Val, Ile, 0.762; Asn, His, Arg, Orn, Lys, Ile, 0.762; Asn, His, Tyr, Met, Ile, Leu, 0.762; Asn, Thr, Cit, Tyr, Lys, Ile, 0.762; Asn, Arg, Lys, Ile, Leu, Phe, 0.762; Gly, Gln, His, Cit, Pro, Ile, 0.762; Gly, Gln, His, Tyr, Met, Leu, 0.762; Gly, Gln, Arg, Tyr, Ile, Phe, 0.762; Gly, Gln, Tyr, Val, Ile, Phe, 0.762; Gly, Gln, Tyr, Orn, Leu, Trp, 0.762; Gly, His, Tyr, Met, Lys, Ile, 0.762; Gly, Arg, Pro, Tyr, Lys, Ile, 0.762; Gln, His, Ala, Cit, Ile, Leu, 0.762; Gln, His, Ala, Arg, Ile, Phe, 0.762; Gln, His, Cit, Pro, Met, Ile, 0.762; Gln, His, Pro, Tyr, Leu, Trp, 0.762; Gln, His, Tyr, Val, Met, Ile, 0.762; Gln, His, Tyr, Met, Ile, Leu, 0.762; Gln, Ala, Tyr, Ile, Phe, Trp, 0.762; Gln, Cit, Arg, Lys, Ile, Trp, 0.762; Gln, Tyr, Met, Ile, Phe, Trp, 0.762; Gln, Tyr, Orn, Ile, Phe, Trp, 0.762; Thr, Arg, Tyr, Met, Lys, Ile, 0.762; Arg, Tyr, Met, Lys, Ile, Leu, 0.762; Ser, Gly, Gln, Arg, Lys, Ile, 0.761; Ser, Gln, His, Tyr, Ile, Leu, 0.761; Ser, His, Tyr, Met, Lys, Ile, 0.761; Asn, Gly, Gln, Pro, Tyr, Leu, 0.761; Asn, Gly, Gln, Tyr, Val, Ile, 0.761; Asn, Gly, His, Cit, Lys, Ile, 0.761; Asn, Gly, Cit, Pro, Lys, Ile, 0.761; Asn, Gly, Cit, Val, Lys, Ile, 0.761; Asn, Gln, His, Ala, Met, Ile, 0.761; Asn, Gln, His, Arg, Pro, Ile, 0.761; Asn, Gln, His, Pro, Met, Ile, 0.761; Asn, Gln, His, Pro, Orn, Ile, 0.761; Asn, Gln, Cit, Orn, Lys, Ile, 0.761; Asn, Gln, Pro, Tyr, Ile, Phe, 0.761; Asn, Gln, Pro, Tyr, Leu, Phe, 0.761; Asn, Gln, Tyr, Met, Ile, Phe, 0.761; Asn, His, Cit, Arg, Tyr, Ile, 0.761; Asn, His, Cit, Tyr, Lys, Ile, 0.761; Asn, His, Cit, Tyr, Ile, Leu, 0.761; Asn, His, Cit, Lys, Ile, Phe, 0.761; Asn, His, Arg, Tyr, Met, Ile, 0.761; Asn, Cit, Arg, Lys, Ile, Phe, 0.761; Asn, Arg, Orn, Lys, Ile, Leu, 0.761; Asn, Arg, Orn, Lys, Ile, Trp, 0.761; Asn, Arg, Lys, Ile, Phe, Trp, 0.761; Gly, Gln, Ala, Tyr, Ile, Leu, 0.761; Gly, Gln, Ala, Tyr, Leu, Phe, 0.761; Gly, Gln, Ala, Tyr, Leu, Trp, 0.761; Gly, Gln, Cit, Tyr, Lys, Leu, 0.761; Gly, Gln, Cit, Tyr, Ile, Trp, 0.761; Gly, Gln, Cit, Tyr, Leu, Phe, 0.761; Gly, Gln, Arg, Tyr, Lys, Leu, 0.761; Gly, His, Cit, Tyr, Ile, Phe, 0.761; Gln, His, Thr, Cit, Tyr, Ile, 0.761; Gln, His, Thr, Arg, Ile, Phe, 0.761; Gln, His, Ala, Cit, Ile, Trp, 0.761; Gln, His, Ala, Pro, Ile, Trp, 0.761; Gln, His, Ala, Tyr, Ile, Leu, 0.761; Gln, His, Ala, Tyr, Leu, Trp, 0.761; Gln, His, Cit, Arg, Val, Ile, 0.761; Gln, His, Cit, Lys, Ile, Phe, 0.761; Gln, His, Arg, Tyr, Met, Ile, 0.761; Gln, Thr, Ala, Tyr, Ile, Phe, 0.761; Gln, Thr, Tyr, Met, Ile, Phe, 0.761; Gln, Pro, Tyr, Met, Ile, Phe, 0.761; Gln, Pro, Tyr, Met, Leu, Phe, 0.761; Gln, Tyr, Val, Met, Ile, Phe, 0.761; Gln, Tyr, Met, Ile, Leu, Trp, 0.761; Gln, Tyr, Orn, Lys, Ile, Phe, 0.761; Thr, Arg, Tyr, Lys, Ile, Trp, 0.761; Ala, Tyr, Met, Lys, Ile, Phe, 0.761; Cit, Arg, Tyr, Lys, Ile, Trp, 0.761; Pro, Tyr, Met, Lys, Ile, Phe, 0.761; Ser, Asn, Arg, Orn, Lys, Ile, 0.761; Ser, Gly, Gln, Tyr, Lys, Ile, 0.761; Ser, Gln, His, Tyr, Val, Ile, 0.761; Ser, Gln, Cit, Arg, Lys, Ile, 0.761; Ser, Ala, Arg, Tyr, Lys, Ile, 0.761; Ser, Cit, Arg, Tyr, Lys, Ile, 0.761; Asn, Gly, Gln, His, Ala, Ile, 0.761; Asn, Gly, Gln, His, Ile, Leu, 0.761; Asn, Gly, Gln, Tyr, Val, Leu, 0.761; Asn, Gly, Gln, Orn, Lys, Ile, 0.761; Asn, Gly, Gln, Orn, Lys, Leu, 0.761; Asn, Gly, Thr, Cit, Tyr, Ile, 0.761; Asn, Gly, Thr, Cit, Lys, Ile, 0.761; Asn, Gly, Arg, Met, Lys, Ile, 0.761; Asn, Gln, His, Thr, Tyr, Leu, 0.761; Asn, Gln, His, Thr, Met, Ile, 0.761; Asn, Gln, His, Arg, Orn, Ile, 0.761; Asn, Gln, His, Pro, Ile, Leu, 0.761; Asn, Gln, His, Orn, Ile, Leu, 0.761; Asn, Gln, His, Lys, Ile, Leu, 0.761; Asn, Gln, Cit, Lys, Ile, Phe, 0.761; Asn, Gln, Tyr, Met, Ile, Leu, 0.761; Asn, Gln, Tyr, Orn, Lys, Leu, 0.761; Asn, Gln, Tyr, Orn, Leu, Trp, 0.761; Asn, His, Cit, Pro, Lys, Ile, 0.761; Asn, His, Arg, Tyr, Orn, Ile, 0.761; Asn, His, Met, Lys, Ile, Phe, 0.761; Asn, His, Lys, Ile, Leu, Phe, 0.761; Asn, Thr, Tyr, Lys, Leu, Phe, 0.761; Asn, Ala, Arg, Lys, Ile, Phe, 0.761; Asn, Cit, Arg, Pro, Tyr, Lys, 0.761; Asn, Arg, Val, Orn, Lys, Ile, 0.761; Asn, Arg, Met, Lys, Ile, Phe, 0.761; Gly, Gln, His, Cit, Tyr, Leu, 0.761; Gly, Gln, His, Tyr, Val, Leu, 0.761; Gly, Gln, His, Tyr, Lys, Leu, 0.761; Gly, Gln, His, Tyr, Ile, Leu, 0.761; Gly, Gln, His, Orn, Ile, Phe, 0.761; Gly, Gln, Arg, Orn, Lys, Ile, 0.761; Gly, Gln, Tyr, Val, Ile, Leu, 0.761; Gly, His, Arg, Tyr, Ile, Phe, 0.761; Gly, His, Tyr, Met, Ile, Phe, 0.761; Gly, Tyr, Met, Lys, Ile, Phe, 0.761; Gln, His, Thr, Ala, Tyr, Ile, 0.761; Gln, His, Cit, Tyr, Val, Ile, 0.761; Gln, His, Cit, Met, Ile, Leu, 0.761; Gln, His, Tyr, Val, Leu, Trp, 0.761; Gln, Thr, Tyr, Val, Ile, Phe, 0.761; Gln, Thr, Tyr, Orn, Leu, Phe, 0.761; Gln, Ala, Tyr, Lys, Ile, Phe, 0.761; Gln, Cit, Tyr, Orn, Leu, Trp, 0.761; Gln, Tyr, Val, Lys, Leu, Phe, 0.761; Gln, Tyr, Met, Leu, Phe, Trp, 0.761; His, Cit, Tyr, Met, Ile, Phe, 0.761; His, Arg, Pro, Tyr, Ile, Phe, 0.761; His, Arg, Tyr, Ile, Leu, Phe, 0.761; His, Tyr, Met, Orn, Ile, Phe, 0.761; Arg, Tyr, Val, Orn, Lys, Ile, 0.761; Arg, Tyr, Ile, Leu, Phe, Trp, 0.761; Tyr, Met, Lys, Ile, Phe, Trp, 0.761; Ser, Asn, Gly, Gln, Orn, Leu, 0.76; Ser, Asn, Gln, His, Val, Ile, 0.76; Ser, Asn, Gln, Arg, Lys, Ile, 0.76; Ser, Asn, Thr, Arg, Lys, Ile, 0.76; Ser, Asn, Arg, Lys, Ile, Trp, 0.76; Ser, Gly, Gln, Tyr, Ile, Leu, 0.76; Ser, Gln, His, Thr, Tyr, Ile, 0.76; Ser, Gln, Thr, Arg, Lys, Ile, 0.76; Ser, Gln, Arg, Orn, Lys, Ile, 0.76; Ser, Gln, Tyr, Orn, Leu, Trp, 0.76; Asn, Gly, Gln, Cit, Lys, Ile, 0.76; Asn, Gly, Gln, Arg, Lys, Ile, 0.76; Asn, Gly, Gln, Lys, Ile, Trp, 0.76; Asn, Gly, His, Arg, Tyr, Ile, 0.76; Asn, Gly, Cit, Tyr, Lys, Ile, 0.76; Asn, Gly, Arg, Pro, Tyr, Lys, 0.76; Asn, Gln, Thr, Tyr, Ile, Phe, 0.76; Asn, Gln, Cit, Val, Lys, Ile, 0.76; Asn, Gln, Pro, Tyr, Lys, Ile, 0.76; Asn, Gln, Tyr, Val, Ile, Leu, 0.76; Asn, Gln, Orn, Lys, Ile, Phe, 0.76; As

n, His, Ala, Cit, Lys, Ile, 0.76; Asn, His, Cit, Tyr, Val, Ile, 0.76; Asn, His, Cit, Met, Lys, Ile, 0.76; Asn, His, Cit, Orn, Lys, Ile, 0.76; Asn, His, Tyr, Met, Ile, Phe, 0.76; Asn, Thr, Arg, Orn, Lys, Ile, 0.76; Asn, Cit, Arg, Orn, Lys, Ile, 0.76; Asn, Cit, Pro, Orn, Lys, Ile, 0.76; Asn, Cit, Tyr, Val, Lys, Ile, 0.76; Asn, Cit, Val, Lys, Ile, Leu, 0.76; Asn, Arg, Val, Lys, Ile, Phe, 0.76; Gly, Gln, His, Ile, Leu, Phe, 0.76; Gly, Gln, His, Ile, Phe, Trp, 0.76; Gly, Gln, Ala, Cit, Tyr, Ile, 0.76; Gly, Gln, Cit, Tyr, Met, Ile, 0.76; Gly, Gln, Arg, Tyr, Leu, Phe, 0.76; Gly, Gln, Tyr, Met, Ile, Trp, 0.76; Gln, His, Thr, Ala, Cit, Ile, 0.76; Gln, His, Ala, Val, Met, Ile, 0.76; Gln, His, Cit, Orn, Lys, Ile, 0.76; Gln, His, Cit, Ile, Leu, Trp, 0.76; Gln, His, Arg, Tyr, Lys, Ile, 0.76; Gln, His, Tyr, Lys, Leu, Trp, 0.76; Gln, His, Val, Met, Ile, Phe, 0.76; Gln, His, Val, Lys, Ile, Phe, 0.76; Gln, Thr, Tyr, Ile, Phe, Trp, 0.76; Gln, Cit, Tyr, Orn, Ile, Leu, 0.76; Gln, Arg, Val, Orn, Lys, Ile, 0.76; Gln, Pro, Tyr, Val, Ile, Phe, 0.76; His, Thr, Arg, Tyr, Ile, Phe, 0.76; His, Arg, Orn, Lys, Ile, Phe, 0.76; Cit, Arg, Tyr, Met, Lys, Ile, 0.76; Ser, Asn, His, Tyr, Met, Ile, 0.759; Ser, Asn, Tyr, Met, Lys, Ile, 0.759; Ser, Gln, Arg, Tyr, Ile, Phe, 0.759; Ser, His, Arg, Tyr, Ile, Phe, 0.759; Asn, Gly, Gln, His, Arg, Ile, 0.759; Asn, Gly, Gln, Lys, Ile, Phe, 0.759; Asn, Gly, His, Lys, Ile, Phe, 0.759; Asn, Gly, Thr, Arg, Lys, Ile, 0.759; Asn, Gly, Tyr, Met, Lys, Ile, 0.759; Asn, Gln, His, Arg, Met, Ile, 0.759; Asn, Gln, His, Met, Ile, Leu, 0.759; Asn, Gln, His, Lys, Ile, Trp, 0.759; Asn, Gln, His, Lys, Leu, Phe, 0.759; Asn, Gln, Ala, Tyr, Lys, Leu, 0.759; Asn, Gln, Orn, Lys, Leu, Phe, 0.759; Asn, Gln, Lys, Ile, Phe, Trp, 0.759; Asn, His, Cit, Val, Lys, Ile, 0.759; Asn, His, Arg, Pro, Tyr, Ile, 0.759; Asn, His, Arg, Orn, Ile, Phe, 0.759; Asn, Thr, Cit, Pro, Lys, Ile, 0.759; Asn, Ala, Cit, Lys, Ile, Leu, 0.759; Asn, Arg, Pro, Tyr, Orn, Lys, 0.759; Asn, Tyr, Val, Met, Lys, Ile, 0.759; Gly, Gln, His, Ala, Tyr, Ile, 0.759; Gly, Gln, Ala, Tyr, Ile, Trp, 0.759; Gly, Gln, Cit, Tyr, Orn, Ile, 0.759; Gly, Gln, Pro, Tyr, Ile, Trp, 0.759; Gly, Gln, Tyr, Val, Met, Ile, 0.759; Gly, Gln, Tyr, Val, Lys, Ile, 0.759; Gly, Gln, Tyr, Val, Lys, Trp, 0.759; Gly, Gln, Tyr, Met, Lys, Leu, 0.759; Gly, Gln, Tyr, Ile, Leu, Trp, 0.759; Gln, His, Thr, Ala, Met, Ile, 0.759; Gln, His, Thr, Cit, Ile, Leu, 0.759; Gln, His, Thr, Tyr, Ile, Leu, 0.759; Gln, His, Ala, Cit, Val, Ile, 0.759; Gln, His, Ala, Arg, Ile, Trp, 0.759; Gln, His, Ala, Pro, Met, Ile, 0.759; Gln, His, Ala, Met, Ile, Trp, 0.759; Gln, His, Ala, Ile, Phe, Trp, 0.759; Gln, His, Cit, Arg, Tyr, Ile, 0.759; Gln, His, Cit, Arg, Ile, Leu, 0.759; Gln, His, Cit, Val, Ile, Trp, 0.759; Gln, His, Arg, Val, Lys, Ile, 0.759; Gln, His, Pro, Tyr, Ile, Leu, 0.759; Gln, His, Tyr, Met, Lys, Ile, 0.759; Gln, Thr, Pro, Tyr, Ile, Phe, 0.759; Gln, Thr, Tyr, Lys, Leu, Phe, 0.759; Gln, Ala, Pro, Tyr, Ile, Phe, 0.759; Gln, Arg, Tyr, Ile, Leu, Trp, 0.759; Gln, Arg, Orn, Lys, Ile, Leu, 0.759; Gln, Tyr, Met, Orn, Ile, Phe, 0.759; Gln, Tyr, Met, Lys, Ile, Trp, 0.759; His, Thr, Tyr, Ile, Phe, Trp, 0.759; His, Cit, Tyr, Ile, Phe, Trp, 0.759; His, Pro, Tyr, Met, Ile, Phe, 0.759; His, Tyr, Met, Lys, Ile, Trp, 0.759; Arg, Tyr, Orn, Lys, Ile, Trp, 0.759; Arg, Tyr, Lys, Ile, Leu, Trp, 0.759; Ser, Asn, Gly, Arg, Lys, Ile, 0.759; Ser, Asn, Gln, His, Arg, Ile, 0.759; Ser, Asn, His, Cit, Tyr, Ile, 0.759; Ser, Asn, His, Arg, Tyr, Ile, 0.759; Ser, Asn, Cit, Tyr, Orn, Ile, 0.759; Ser, Gly, Gln, Tyr, Ile, Trp, 0.759; Ser, Gly, Gln, Tyr, Leu, Trp, 0.759; Ser, Gln, His, Cit, Tyr, Ile, 0.759; Ser, Gln, His, Arg, Ile, Phe, 0.759; Ser, Gln, Thr, Tyr, Lys, Ile, 0.759; Ser, Gln, Tyr, Lys, Ile, Leu, 0.759; Ser, His, Thr, Tyr, Ile, Phe, 0.759; Ser, Arg, Lys, Ile, Phe, Trp, 0.759; Asn, Gly, Cit, Arg, Tyr, Ile, 0.759; Asn, Gly, Cit, Arg, Lys, Ile, 0.759; Asn, Gly, Arg, Lys, Ile, Trp, 0.759; Asn, Gly, Tyr, Lys, Leu, Phe, 0.759; Asn, Gln, His, Thr, Pro, Ile, 0.759; Asn, Gln, His, Pro, Ile, Trp, 0.759; Asn, Gln, His, Tyr, Val, Leu, 0.759; Asn, Gln, His, Tyr, Lys, Leu, 0.759; Asn, Gln, His, Orn, Lys, Ile, 0.759; Asn, Gln, His, Orn, Ile, Trp, 0.759; Asn, Gln, Ala, Cit, Lys, Ile, 0.759; Asn, Gln, Ala, Tyr, Ile, Phe, 0.759; Asn, Gln, Cit, Lys, Leu, Phe, 0.759; Asn, Gln, Val, Lys, Leu, Phe, 0.759; Asn, His, Cit, Lys, Ile, Leu, 0.759; Asn, Thr, Cit, Tyr, Leu, Phe, 0.759; Asn, Thr, Tyr, Lys, Ile, Phe, 0.759; Asn, Arg, Tyr, Met, Lys, Leu, 0.759; Asn, Pro, Tyr, Lys, Leu, Phe, 0.759; Asn, Tyr, Met, Lys, Ile, Trp, 0.759; Gly, Gln, His, Ala, Tyr, Leu, 0.759; Gly, Gln, Thr, Tyr, Lys, Ile, 0.759; Gly, Gln, Ala, Tyr, Lys, Ile, 0.759; Gly, Gln, Cit, Tyr, Val, Ile, 0.759; Gly, Gln, Arg, Lys, Ile, Leu, 0.759; Gly, Gln, Pro, Tyr, Lys, Ile, 0.759; Gly, Gln, Pro, Tyr, Ile, Leu, 0.759; Gly, Gln, Tyr, Val, Leu, Trp, 0.759; Gly, His, Tyr, Met, Ile, Trp, 0.759; Gln, His, Thr, Tyr, Val, Ile, 0.759; Gln, His, Thr, Tyr, Lys, Ile, 0.759; Gln, His, Ala, Val, Ile, Trp, 0.759; Gln, His, Ala, Orn, Ile, Phe, 0.759; Gln, His, Cit, Arg, Met, Ile, 0.759; Gln, His, Cit, Val, Met, Ile, 0.759; Gln, His, Cit, Val, Ile, Leu, 0.759; Gln, His, Pro, Tyr, Val, Ile, 0.759; Gln, His, Tyr, Val, Orn, Trp, 0.759; Gln, His, Tyr, Met, Lys, Leu, 0.759; Gln, His, Val, Orn, Ile, Phe, 0.759; Gln, His, Met, Ile, Leu, Phe, 0.759; Gln, His, Orn, Ile, Leu, Phe, 0.759; Gln, His, Orn, Ile, Phe, Trp, 0.759; Gln, Thr, Tyr, Orn, Ile, Phe, 0.759; Gln, Thr, Tyr, Leu, Phe, Trp, 0.759; Gln, Ala, Arg, Lys, Ile, Phe, 0.759; Gln, Ala, Tyr, Lys, Leu, Phe, 0.759; Gln, Ala, Tyr, Ile, Leu, Phe, 0.759; Gln, Cit, Tyr, Lys, Ile, Trp, 0.759; Gln, Arg, Tyr, Orn, Lys, Ile, 0.759; Gln, Arg, Val, Lys, Ile, Leu, 0.759; Gln, Pro, Tyr, Orn, Ile, Phe, 0.759; Gln, Tyr, Val, Met, Lys, Ile, 0.759; Gln, Tyr, Val, Orn, Ile, Phe, 0.759; His, Thr, Ala, Tyr, Ile, Phe, 0.759; His, Ala, Cit, Tyr, Ile, Phe, 0.759; His, Ala, Arg, Tyr, Ile, Phe, 0.759; His, Cit, Arg, Tyr, Met, Ile, 0.759; His, Arg, Tyr, Ile, Phe, Trp, 0.759; His, Pro, Tyr, Met, Ile, Trp, 0.759; His, Tyr, Val, Met, Lys, Ile, 0.759; His, Tyr, Met, Lys, Ile, Leu, 0.759; Thr, Tyr, Orn, Lys, Ile, Phe, 0.759; Cit, Tyr, Met, Lys, Ile, Phe, 0.759; Cit, Tyr, Lys, Ile, Leu, Trp, 0.759; Arg, Pro, Tyr, Orn, Lys, Ile, 0.759; Arg, Tyr, Orn, Lys, Ile, Leu, 0.759; Ser, Asn, Gly, Gln, Lys, Leu, 0.758; Ser, Asn, Gln, His, Cit, Ile, 0.758; Ser, Asn, Gln, His, Tyr, Leu, 0.758; Ser, Asn, Gln, His, Lys, Ile, 0.758; Ser, Asn, Cit, Arg, Lys, Ile, 0.758; Ser, Gln, His, Tyr, Leu, Trp, 0.758; Ser, Gln, Cit, Tyr, Ile, Phe, 0.758; Ser, Gln, Arg, Met, Lys, Ile, 0.758; Ser, Gln, Tyr, Met, Leu, Phe, 0.758; Ser, Gln, Tyr, Ile, Leu, Trp, 0.758; Ser, His, Tyr, Met, Ile, Trp, 0.758; Asn, Gly, Gln, His, Tyr, Val, 0.758; Asn, Gly, Gln, Ala, Lys, Ile, 0.758; Asn, Gly, Gln, Arg, Tyr, Leu, 0.758; Asn, Gly, Gln, Tyr, Val, Lys, 0.758; Asn, Gly, Gln, Tyr, Ile, Phe, 0.758; Asn, Gly, Gln, Val, Lys, Leu, 0.758; Asn, Gly, Cit, Tyr, Ile, Trp, 0.758; Asn, Gln, His, Thr, Arg, Ile, 0.758; Asn, Gln, His, Thr, Lys, Ile, 0.758; Asn, Gln, His, Met, Ile, Trp, 0.758; Asn, Gln, Cit, Arg, Lys, Ile, 0.758; Asn, Gln, Cit, Tyr, Ile, Phe, 0.758; Asn, Gln, Tyr, Met, Lys, Leu, 0.758; Asn, His, Cit, Tyr, Ile, Trp, 0.758; Asn, His, Tyr, Lys, Ile, Phe, 0.758; Asn, His, Tyr, Ile, Phe, Trp, 0.758; Asn, Thr, Cit, Lys, Ile, Leu, 0.758; Asn, Ala, Cit, Tyr, Ile, Phe, 0.758; Asn, Ala, Tyr, Met, Lys, Ile, 0.758; Asn, Cit, Pro, Tyr, Lys, Ile, 0.758; Asn, Cit, Pro, Met, Lys, Ile, 0.758; Asn, Cit, Pro, Lys, Ile, Phe, 0.758; Asn, Cit, Tyr, Orn, Ile, Phe, 0.758; Asn, Cit, Lys, Ile, Leu, Phe, 0.758; Asn, Cit, Lys, Ile, Leu, Trp, 0.758; Asn, Arg, Tyr, Orn, Lys, Leu, 0.758; Gly, Gln, His, Thr, Tyr, Ile, 0.758; Gly, Gln, His, Ala, Met, Ile, 0.758; Gly, Gln, His, Tyr, Orn, Leu, 0.758; Gly, Gln, His, Tyr, Lys, Ile, 0.758; Gly, Gln, Thr, Tyr, Ile, Trp, 0.758; Gly, Gln, Thr, Tyr, Leu, Trp, 0.758; Gly, Gln, Ala, Tyr, Val, Ile, 0.758; Gln, His, Thr, Cit, Arg, Ile, 0.758; Gln, His, Thr, Cit, Ile, Trp, 0.758; Gln, His, Thr, Pro, Tyr, Ile, 0.758; Gln, His, Ala, Cit, Met, Ile, 0.758; Gln, His, Ala, Val, Ile, Phe, 0.758; Gln, His, Ala, Ile, Leu, Phe, 0.758; Gln, His, Cit, Tyr, Met, Ile, 0.758; Gln, His, Arg, Met, Ile, Phe, 0.758; Gln, His, Orn, Lys, Ile, Phe, 0.758; Gln, Thr, Arg, Val, Lys, Ile, 0.758; Gln, Ala, Tyr, Lys, Ile, Trp, 0.758; Gln, Cit, Tyr, Orn, Leu, Phe, 0.758; Gln, Cit, Ile, Leu, Phe, Trp, 0.758; Gln, Arg, Tyr, Val, Ile, Phe, 0.758; His, Ala, Arg, Tyr, Lys, Ile, 0.758; His, Ala, Tyr, Ile, Phe, Trp, 0.758; His, Cit, Arg, Tyr, Lys, Ile, 0.758; His, Cit, Tyr, Ile, Leu, Phe, 0.758; His, Arg, Pro, Tyr, Lys, Ile, 0.758; His, Arg, Tyr, Val, Lys, Ile, 0.758; Thr, Arg, Tyr, Ile, Leu, Phe, 0.758; Tyr, Val, Met, Lys, Ile, Phe, 0.758; Tyr, Met, Lys, Ile, Leu, Phe, 0.758; Ser, Asn, Gly, Gln, Tyr, Ile, 0.757; Ser, Gly, Gln, Thr, Tyr, Ile, 0.757; Ser, Gln, His, Orn, Ile, Phe, 0.757; Ser, His, Cit, Tyr, Ile, Phe, 0.757; Asn, Gly, Gln, His, Met, Ile, 0.757; Asn, Gly, Gln, Thr, Lys, Ile, 0.757; Asn, Gly, Gln, Cit, Orn, Ile, 0.757; Asn, Gly, Gln, Tyr, Orn, Leu, 0.757; Asn, Gly, Thr, Tyr, Leu, Phe, 0.757; Asn, Gly, Cit, Met, Lys, Ile, 0.757; Asn, Gly, Arg, Tyr, Leu, Phe, 0.757; Asn, Gln, His, Cit, Tyr, Leu, 0.757; Asn, Gln, His, Val, Ile, Trp, 0.757; Asn, Gln, His, Met, Orn, Ile, 0.757; Asn, Gln, Thr, Tyr, Ile, Leu, 0.757; Asn, Gln, Cit, Ile, Leu, Phe, 0.757; Asn, Thr, Arg, Lys, Ile, Trp, 0.757; Asn, Arg, Tyr, Lys, Leu, Trp, 0.757; Gly, Gln, His, Thr, Cit, Ile, 0.757; Gly, Gln, His, Ala, Ile, Phe, 0.757; Gly, Gln, Ala, Arg, Lys, Ile, 0.757; Gly, Gln, Cit, Pro, Tyr, Ile, 0.757; Gly, Gln, Arg, Tyr, Ile, Leu, 0.757; Gly, Gln, Orn, Lys, Ile, Phe, 0.757; Gln, His, Ala, Pro, Ile, Phe, 0.757; Gln, His, Arg, Met, Lys, Ile, 0.757; Gln, His, Val, Met, Orn, Ile, 0.757; Gln, Thr, Cit, Tyr, Ile, Phe, 0.757; Gln, Ala, Tyr, Orn, Ile, Phe, 0.757; Gln, Cit, Pro, Tyr, Ile, Phe, 0.757; Gln, Arg, Tyr, Lys, Leu, Trp, 0.757; Gln, Arg, Tyr, Ile, Phe, Trp, 0.757; Gln, Tyr, Orn, Lys, Leu, Phe, 0.757; His, Cit, Tyr, Orn, Ile, Phe, 0.757; Thr, Cit, Tyr, Lys, Ile, Phe, 0.757; Cit, Pro, Tyr, Lys, Ile, Trp, 0.757; Arg, Tyr, Met, Ile, Leu, Phe, 0.757; Ser, Asn, Gly, Gln, His, Ile, 0.757; Ser, Asn, Gly, Gln, Tyr, Leu, 0.757; Ser, Asn, Gln, His, Thr, I

le, 0.757; Ser, Asn, Gln, Tyr, Leu, Trp, 0.757; Ser, Asn, Arg, Met, Lys, Ile, 0.757; Ser, Gly, Gln, His, Ile, Phe, 0.757; Ser, Tyr, Met, Lys, Ile, Phe, 0.757; Asn, Gly, Gln, His, Pro, Ile, 0.757; Asn, Gly, Gln, Met, Lys, Ile, 0.757; Asn, Gly, Pro, Tyr, Ile, Leu, 0.757; Asn, Gln, His, Ala, Lys, Ile, 0.757; Asn, Gln, His, Arg, Ile, Trp, 0.757; Asn, Gln, His, Ile, Leu, Trp, 0.757; Asn, His, Thr, Tyr, Leu, Phe, 0.757; Asn, His, Cit, Lys, Ile, Trp, 0.757; Asn, Arg, Pro, Lys, Ile, Phe, 0.757; Asn, Arg, Lys, Ile, Leu, Trp, 0.757; Asn, Tyr, Val, Lys, Leu, Phe, 0.757; Asn, Tyr, Lys, Leu, Phe, Trp, 0.757; Gly, Gln, His, Cit, Ile, Trp, 0.757; Gly, Gln, His, Tyr, Val, Met, 0.757; Gly, Gln, His, Lys, Ile, Phe, 0.757; Gly, Gln, Arg, Val, Lys, Ile, 0.757; Gln, His, Arg, Tyr, Leu, Phe, 0.757; Gln, His, Pro, Ile, Phe, Trp, 0.757; Gln, His, Tyr, Val, Met, Orn, 0.757; Gln, His, Tyr, Val, Orn, Phe, 0.757; Gln, His, Tyr, Val, Lys, Ile, 0.757; Gln, His, Tyr, Val, Leu, Phe, 0.757; Gln, His, Tyr, Orn, Leu, Trp, 0.757; Gln, His, Val, Met, Ile, Leu, 0.757; Gln, Thr, Arg, Orn, Lys, Ile, 0.757; Gln, Thr, Tyr, Met, Lys, Ile, 0.757; Gln, Cit, Pro, Tyr, Leu, Phe, 0.757; Gln, Arg, Val, Met, Lys, Ile, 0.757; Gln, Arg, Val, Lys, Ile, Trp, 0.757; Gln, Tyr, Val, Orn, Leu, Phe, 0.757; Gln, Tyr, Val, Lys, Ile, Trp, 0.757; Ala, Arg, Tyr, Lys, Ile, Trp, 0.757; Arg, Tyr, Lys, Leu, Phe, Trp, 0.757; Tyr, Met, Orn, Lys, Ile, Phe, 0.757; Ser, Asn, Gln, His, Ala, Ile, 0.757; Ser, Asn, His, Arg, Lys, Ile, 0.757; Ser, Asn, Ala, Arg, Lys, Ile, 0.757; Ser, Asn, Tyr, Met, Leu, Phe, 0.757; Ser, Gln, His, Tyr, Lys, Ile, 0.757; Ser, Gln, His, Ile, Phe, Trp, 0.757; Ser, Gln, Thr, Tyr, Leu, Phe, 0.757; Ser, His, Tyr, Met, Ile, Phe, 0.757; Ser, Arg, Tyr, Ile, Leu, Phe, 0.757; Asn, Gly, Gln, Thr, Tyr, Ile, 0.757; Asn, Gly, Gln, Thr, Tyr, Leu, 0.757; Asn, Gly, Gln, Ala, Tyr, Leu, 0.757; Asn, Gly, Gln, Arg, Tyr, Ile, 0.757; Asn, Gly, Gln, Tyr, Met, Ile, 0.757; Asn, Gly, Gln, Tyr, Orn, Ile, 0.757; Asn, Gly, Gln, Lys, Leu, Trp, 0.757; Asn, Gln, His, Arg, Tyr, Val, 0.757; Asn, Gln, His, Tyr, Met, Leu, 0.757; Asn, Gln, His, Met, Lys, Ile, 0.757; Asn, Gln, Thr, Tyr, Lys, Ile, 0.757; Asn, Gln, Cit, Tyr, Orn, Ile, 0.757; Asn, Gln, Cit, Tyr, Ile, Leu, 0.757; Asn, Gln, Val, Ile, Leu, Phe, 0.757; Asn, His, Thr, Tyr, Ile, Phe, 0.757; Asn, His, Tyr, Met, Ile, Trp, 0.757; Asn, His, Tyr, Orn, Ile, Phe, 0.757; Asn, His, Orn, Lys, Ile, Phe, 0.757; Asn, Thr, Cit, Orn, Lys, Ile, 0.757; Asn, Ala, Cit, Pro, Lys, Ile, 0.757; Asn, Cit, Arg, Val, Lys, Ile, 0.757; Asn, Cit, Arg, Lys, Ile, Trp, 0.757; Asn, Cit, Tyr, Met, Ile, Phe, 0.757; Asn, Cit, Tyr, Lys, Leu, Phe, 0.757; Asn, Arg, Val, Lys, Ile, Leu, 0.757; Asn, Pro, Tyr, Met, Lys, Ile, 0.757; Asn, Tyr, Met, Ile, Leu, Phe, 0.757; Asn, Tyr, Orn, Ile, Leu, Phe, 0.757; Asn, Tyr, Lys, Ile, Leu, Phe, 0.757; Gly, Gln, His, Tyr, Val, Phe, 0.757; Gly, Gln, His, Val, Ile, Phe, 0.757; Gly, Gln, Thr, Cit, Tyr, Ile, 0.757; Gly, Gln, Thr, Arg, Lys, Ile, 0.757; Gly, Gln, Cit, Tyr, Leu, Trp, 0.757; Gly, Gln, Arg, Tyr, Val, Ile, 0.757; Gly, Gln, Lys, Ile, Leu, Phe, 0.757; Gly, Cit, Tyr, Lys, Ile, Trp, 0.757; Gly, Arg, Tyr, Ile, Leu, Phe, 0.757; Gln, His, Thr, Ala, Ile, Phe, 0.757; Gln, His, Thr, Cit, Met, Ile, 0.757; Gln, His, Thr, Tyr, Leu, Phe, 0.757; Gln, His, Ala, Arg, Met, Ile, 0.757; Gln, His, Ala, Tyr, Lys, Leu, 0.757; Gln, His, Ala, Met, Ile, Phe, 0.757; Gln, His, Cit, Arg, Ile, Trp, 0.757; Gln, His, Arg, Pro, Val, Ile, 0.757; Gln, His, Tyr, Met, Leu, Trp, 0.757; Gln, His, Tyr, Lys, Ile, Leu, 0.757; Gln, Thr, Tyr, Met, Leu, Phe, 0.757; Gln, Ala, Tyr, Val, Ile, Phe, 0.757; Gln, Cit, Arg, Lys, Ile, Leu, 0.757; Gln, Cit, Pro, Orn, Ile, Phe, 0.757; Gln, Cit, Tyr, Lys, Leu, Phe, 0.757; Gln, Tyr, Val, Met, Leu, Phe, 0.757; Gln, Tyr, Val, Ile, Leu, Trp, 0.757; His, Cit, Pro, Tyr, Ile, Phe, 0.757; His, Cit, Tyr, Lys, Ile, Phe, 0.757; His, Pro, Tyr, Ile, Phe, Trp, 0.757; Ala, Arg, Pro, Tyr, Lys, Ile, 0.757; Cit, Tyr, Met, Lys, Ile, Trp, 0.757; Cit, Tyr, Orn, Lys, Ile, Trp, 0.757; Arg, Pro, Tyr, Lys, Ile, Trp, 0.757; Arg, Pro, Tyr, Ile, Leu, Phe, 0.757; Arg, Tyr, Orn, Ile, Leu, Phe, 0.757; Arg, Orn, Lys, Ile, Leu, Phe, 0.757; Ser, Asn, Gln, Val, Lys, Ile, 0.756; Ser, Asn, Tyr, Lys, Leu, Phe, 0.756; Ser, Gly, His, Tyr, Ile, Phe, 0.756; Ser, Gln, His, Cit, Pro, Ile, 0.756; Ser, Gln, His, Cit, Ile, Trp, 0.756; Ser, Gln, His, Arg, Lys, Ile, 0.756; Ser, Gln, His, Tyr, Lys, Leu, 0.756; Ser, Gln, Arg, Lys, Ile, Leu, 0.756; Ser, Gln, Pro, Tyr, Leu, Phe, 0.756; Ser, Gln, Lys, Ile, Phe, Trp, 0.756; Ser, His, Pro, Tyr, Ile, Phe, 0.756; Asn, Gly, Gln, His, Ile, Trp, 0.756; Asn, Gly, Gln, Val, Lys, Ile, 0.756; Asn, Gly, Ala, Cit, Tyr, Ile, 0.756; Asn, Gly, Cit, Tyr, Ile, Phe, 0.756; Asn, Gly, Cit, Orn, Lys, Ile, 0.756; Asn, Gly, Cit, Lys, Ile, Phe, 0.756; Asn, Gly, Arg, Val, Lys, Ile, 0.756; Asn, Gly, Tyr, Met, Ile, Leu, 0.756; Asn, Gln, His, Thr, Ile, Leu, 0.756; Asn, Gln, His, Ala, Tyr, Leu, 0.756; Asn, Gln, His, Cit, Lys, Ile, 0.756; Asn, Gln, His, Pro, Tyr, Leu, 0.756; Asn, Gln, Ala, Tyr, Lys, Ile, 0.756; Asn, Gln, Arg, Tyr, Lys, Leu, 0.756; Asn, Gln, Met, Lys, Leu, Phe, 0.756; Asn, His, Ala, Arg, Tyr, Ile, 0.756; Asn, His, Cit, Tyr, Orn, Leu, 0.756; Asn, His, Tyr, Val, Met, Ile, 0.756; Asn, His, Lys, Ile, Phe, Trp, 0.756; Asn, Thr, Cit, Arg, Lys, Ile, 0.756; Asn, Thr, Tyr, Val, Leu, Phe, 0.756; Asn, Thr, Tyr, Met, Lys, Ile, 0.756; Asn, Thr, Tyr, Met, Leu, Phe, 0.756; Asn, Cit, Arg, Lys, Ile, Leu, 0.756; Asn, Cit, Pro, Val, Lys, Ile, 0.756; Asn, Cit, Val, Orn, Lys, Ile, 0.756; Asn, Cit, Orn, Lys, Ile, Leu, 0.756; Asn, Arg, Met, Orn, Lys, Ile, 0.756; Gly, Gln, His, Cit, Arg, Ile, 0.756; Gly, Gln, His, Pro, Tyr, Leu, 0.756; Gly, Gln, His, Met, Ile, Phe, 0.756; Gly, Gln, Ala, Tyr, Met, Ile, 0.756; Gly, Gln, Cit, Val, Lys, Ile, 0.756; Gly, Gln, Arg, Pro, Tyr, Ile, 0.756; Gly, Gln, Arg, Met, Lys, Ile, 0.756; Gly, Gln, Tyr, Val, Met, Lys, 0.756; Gly, Gln, Tyr, Orn, Lys, Ile, 0.756; Gly, Gln, Tyr, Orn, Ile, Trp, 0.756; Gln, His, Thr, Orn, Ile, Phe, 0.756; Gln, His, Thr, Lys, Ile, Phe, 0.756; Gln, His, Ala, Tyr, Val, Trp, 0.756; Gln, His, Met, Orn, Lys, Ile, 0.756; Gln, His, Met, Orn, Ile, Phe, 0.756; Gln, His, Lys, Ile, Phe, Trp, 0.756; Gln, Thr, Arg, Tyr, Lys, Ile, 0.756; Gln, Thr, Pro, Tyr, Leu, Phe, 0.756; Gln, Thr, Tyr, Val, Leu, Phe, 0.756; Gln, Ala, Arg, Orn, Lys, Ile, 0.756; Gln, Cit, Arg, Val, Lys, Ile, 0.756; Gln, Cit, Tyr, Ile, Phe, Trp, 0.756; Gln, Arg, Tyr, Val, Lys, Ile, 0.756; Gln, Tyr, Val, Met, Ile, Leu, 0.756; Gln, Orn, Lys, Ile, Leu, Phe, 0.756; His, Ala, Cit, Tyr, Met, Ile, 0.756; His, Tyr, Val, Met, Ile, Phe, 0.756; His, Tyr, Met, Ile, Leu, Phe, 0.756; Thr, Arg, Tyr, Orn, Lys, Ile, 0.756; Thr, Tyr, Met, Lys, Ile, Phe, 0.756; Ala, Cit, Arg, Tyr, Lys, Ile, 0.756; Ala, Arg, Tyr, Orn, Lys, Ile, 0.756; Cit, Arg, Pro, Tyr, Orn, Lys, 0.756; Cit, Arg, Tyr, Lys, Ile, Leu, 0.756; Cit, Tyr, Lys, Ile, Phe, Trp, 0.756; Arg, Tyr, Val, Ile, Leu, Phe, 0.756; Ser, Asn, Gln, His, Met, Ile, 0.756; Ser, Asn, Gln, His, Ile, Trp, 0.756; Ser, Asn, Gln, Tyr, Val, Ile, 0.756; Ser, Asn, Gln, Lys, Ile, Trp, 0.756; Ser, Asn, His, Cit, Lys, Ile, 0.756; Ser, Asn, Thr, Tyr, Leu, Phe, 0.756; Ser, Gly, Gln, Cit, Tyr, Ile, 0.756; Ser, Gln, His, Arg, Orn, Ile, 0.756; Ser, Gln, His, Arg, Ile, Trp, 0.756; Ser, Gln, His, Tyr, Leu, Phe, 0.756; Ser, Gln, His, Val, Ile, Phe, 0.756; Ser, Gln, His, Met, Lys, Ile, 0.756; Ser, Gln, Cit, Tyr, Leu, Phe, 0.756; Ser, Gln, Tyr, Val, Lys, Ile, 0.756; Ser, His, Ala, Tyr, Ile, Phe, 0.756; Asn, Gly, Gln, His, Lys, Leu, 0.756; Asn, Gly, Gln, Orn, Leu, Phe, 0.756; Asn, Gly, Cit, Lys, Ile, Trp, 0.756; Asn, Gly, Arg, Tyr, Ile, Leu, 0.756; Asn, Gln, His, Orn, Lys, Leu, 0.756; Asn, Gln, His, Orn, Leu, Phe, 0.756; Asn, Gln, Thr, Val, Leu, Phe, 0.756; Asn, Gln, Ala, Tyr, Ile, Leu, 0.756; Asn, Gln, Cit, Tyr, Orn, Leu, 0.756; Asn, Gln, Cit, Tyr, Lys, Leu, 0.756; Asn, Gln, Cit, Lys, Ile, Trp, 0.756; Asn, Gln, Arg, Met, Lys, Ile, 0.756; Asn, Gln, Arg, Ile, Leu, Phe, 0.756; Asn, Gln, Tyr, Val, Lys, Leu, 0.756; Asn, Gln, Lys, Ile, Leu, Trp, 0.756; Asn, Gln, Ile, Leu, Phe, Trp, 0.756; Asn, His, Thr, Tyr, Met, Ile, 0.756; Asn, His, Cit, Tyr, Ile, Phe, 0.756; Asn, His, Arg, Tyr, Ile, Leu, 0.756; Asn, His, Pro, Tyr, Met, Ile, 0.756; Asn, His, Val, Lys, Ile, Phe, 0.756; Asn, Thr, Arg, Val, Lys, Ile, 0.756; Asn, Thr, Pro, Tyr, Leu, Phe, 0.756; Asn, Thr, Tyr, Leu, Phe, Trp, 0.756; Asn, Thr, Lys, Ile, Leu, Phe, 0.756; Asn, Ala, Cit, Tyr, Orn, Ile, 0.756; Asn, Ala, Cit, Orn, Lys, Ile, 0.756; Asn, Ala, Arg, Orn, Lys, Ile, 0.756; Asn, Cit, Arg, Met, Lys, Ile, 0.756; Asn, Cit, Pro, Tyr, Ile, Phe, 0.756; Asn, Cit, Tyr, Orn, Ile, Trp, 0.756; Asn, Cit, Orn, Lys, Ile, Phe, 0.756; Asn, Tyr, Met, Lys, Ile, Phe, 0.756; Asn, Tyr, Orn, Lys, Leu, Phe, 0.756; Asn, Orn, Lys, Ile, Leu, Phe, 0.756; Gly, Gln, His, Ala, Ile, Trp, 0.756; Gly, Gln, His, Cit, Met, Ile, 0.756; Gly, Gln, His, Cit, Ile, Leu, 0.756; Gly, Gln, Thr, Ala, Tyr, Ile, 0.756; Gly, Gln, Thr, Tyr, Ile, Leu, 0.756; Gly, Gln, Lys, Ile, Phe, Trp, 0.756; Gly, His, Cit, Tyr, Met, Ile, 0.756; Gly, Arg, Tyr, Lys, Ile, Trp, 0.756; Gln, His, Thr, Ile, Phe, Trp, 0.756; Gln, His, Cit, Tyr, Lys, Ile, 0.756; Gln, His, Pro, Orn, Ile, Phe, 0.756; Gln, His, Tyr, Lys, Ile, Trp, 0.756; Gln, His, Met, Lys, Ile, Phe, 0.756; Gln, His, Met, Ile, Phe, Trp, 0.756; Gln, His, Orn, Lys, Leu, Phe, 0.756; Gln, Thr, Cit, Arg, Lys, Ile, 0.756; Gln, Thr, Tyr, Ile, Leu, Trp, 0.756; Gln, Ala, Arg, Lys, Ile, Trp, 0.756; Gln, Ala, Tyr, Met, Lys, Ile, 0.756; Gln, Ala, Tyr, Ile, Leu, Trp, 0.756; Gln, Cit, Arg, Tyr, Orn, Ile, 0.756; Gln, Cit, Tyr, Lys, Leu, Trp, 0.756; Gln, Arg, Met, Lys, Ile, Phe, 0.756; Gln, Tyr, Met, Lys, Leu, Phe, 0.756; Gln, Tyr, Orn, Ile, Leu, Trp, 0.756; Gln, Tyr, Lys, Ile, Leu, Trp, 0.756; His, Ala, Tyr, Met, Ile, Trp, 0.756; His, Cit, Tyr, Met, Orn, Ile, 0.756; His, Cit, Tyr, Lys, Ile, Trp, 0.756; His, Arg, Tyr, Val, Ile, Phe, 0.756; Thr, Ala, Arg, Tyr, Lys, Ile, 0.756; Ala, Cit, Tyr, Lys, Ile, Trp, 0.756; Ser, Asn, Gln, His, Orn, Leu, 0.755; Ser, Asn, Gln, His, Ile, Leu, 0.755; Ser, Asn, Gln, Cit, Tyr, Ile, 0.755; Ser, Asn, Gln, Cit, Lys, Ile, 0.755; Ser, Asn, His, Pro, Tyr, Ile, 0.755; Ser, Gly, Gln, Ala, Tyr, Ile, 0.755; Ser, Gly, Gln, Tyr, Met, Ile, 0.755; Ser, Gly, Cit, Tyr

, Val, Ile, 0.755; Ser, Gln, His, Ala, Cit, Ile, 0.755; Ser, Gln, His, Cit, Val, Ile, 0.755; Ser, Gln, Pro, Tyr, Ile, Trp, 0.755; Asn, Gly, Gln, His, Thr, Ile, 0.755; Asn, Gly, Gln, Cit, Lys, Leu, 0.755; Asn, Gly, His, Pro, Tyr, Ile, 0.755; Asn, Gly, Cit, Tyr, Orn, Leu, 0.755; Asn, Gly, Cit, Tyr, Leu, Phe, 0.755; Asn, Gly, Arg, Tyr, Val, Lys, 0.755; Asn, Gly, Tyr, Lys, Leu, Trp, 0.755; Asn, Gln, His, Pro, Tyr, Val, 0.755; Asn, Gln, His, Tyr, Val, Trp, 0.755; Asn, Gln, His, Tyr, Orn, Lys, 0.755; Asn, Gln, His, Tyr, Leu, Trp, 0.755; Asn, Gln, Ala, Lys, Ile, Trp, 0.755; Asn, Gln, Arg, Pro, Lys, Ile, 0.755; Asn, Gln, Pro, Tyr, Ile, Leu, 0.755; Asn, Gln, Tyr, Val, Ile, Phe, 0.755; Asn, His, Thr, Cit, Lys, Ile, 0.755; Asn, His, Ala, Tyr, Met, Ile, 0.755; Asn, His, Arg, Tyr, Ile, Phe, 0.755; Asn, His, Arg, Tyr, Ile, Trp, 0.755; Asn, His, Tyr, Met, Orn, Ile, 0.755; Asn, Thr, Arg, Met, Lys, Ile, 0.755; Asn, Thr, Arg, Lys, Ile, Leu, 0.755; Asn, Ala, Arg, Pro, Tyr, Lys, 0.755; Asn, Cit, Tyr, Met, Ile, Leu, 0.755; Asn, Cit, Met, Lys, Ile, Leu, 0.755; Asn, Pro, Tyr, Met, Leu, Phe, 0.755; Asn, Tyr, Met, Lys, Leu, Phe, 0.755; Asn, Tyr, Met, Leu, Phe, Trp, 0.755; Gly, Gln, His, Pro, Met, Ile, 0.755; Gly, Gln, Ala, Arg, Tyr, Ile, 0.755; Gly, Gln, Cit, Arg, Tyr, Ile, 0.755; Gly, Gln, Arg, Tyr, Val, Lys, 0.755; Gly, Gln, Tyr, Met, Leu, Trp, 0.755; Gly, Gln, Tyr, Orn, Ile, Leu, 0.755; Gly, His, Thr, Tyr, Ile, Phe, 0.755; Gly, Arg, Tyr, Met, Lys, Leu, 0.755; Gly, Arg, Tyr, Lys, Leu, Trp, 0.755; Gln, His, Thr, Met, Orn, Ile, 0.755; Gln, His, Ala, Arg, Val, Ile, 0.755; Gln, His, Ala, Ile, Leu, Trp, 0.755; Gln, His, Cit, Val, Lys, Ile, 0.755; Gln, His, Arg, Val, Orn, Ile, 0.755; Gln, His, Arg, Orn, Lys, Ile, 0.755; Gln, His, Pro, Val, Ile, Phe, 0.755; Gln, His, Tyr, Val, Lys, Leu, 0.755; Gln, His, Tyr, Val, Lys, Trp, 0.755; Gln, His, Tyr, Orn, Lys, Ile, 0.755; Gln, His, Tyr, Orn, Lys, Leu, 0.755; Gln, Thr, Arg, Met, Lys, Ile, 0.755; Gln, Ala, Cit, Tyr, Ile, Phe, 0.755; Gln, Ala, Tyr, Leu, Phe, Trp, 0.755; Gln, Cit, Arg, Tyr, Ile, Phe, 0.755; Gln, Cit, Arg, Tyr, Leu, Phe, 0.755; Gln, Arg, Met, Orn, Lys, Ile, 0.755; Gln, Pro, Tyr, Val, Leu, Phe, 0.755; Gln, Pro, Tyr, Met, Lys, Ile, 0.755; Gln, Pro, Tyr, Orn, Leu, Phe, 0.755; His, Ala, Arg, Lys, Ile, Phe, 0.755; His, Ala, Tyr, Ile, Leu, Phe, 0.755; His, Arg, Tyr, Lys, Ile, Leu, 0.755; His, Tyr, Lys, Ile, Leu, Phe, 0.755; Thr, Tyr, Lys, Ile, Phe, Trp, 0.755; Ala, Arg, Tyr, Val, Lys, Ile, 0.755; Arg, Pro, Tyr, Val, Lys, Ile, 0.755; Ser, Asn, Gln, Thr, Lys, Ile, 0.754; Ser, Asn, Gln, Ala, Tyr, Ile, 0.754; Ser, Asn, Gln, Tyr, Lys, Leu, 0.754; Ser, Asn, Gln, Lys, Ile, Phe, 0.754; Ser, Asn, His, Lys, Ile, Phe, 0.754; Ser, Asn, Cit, Tyr, Ile, Leu, 0.754; Ser, Gln, His, Cit, Arg, Ile, 0.754; Ser, Gln, His, Pro, Tyr, Ile, 0.754; Ser, Gln, Ala, Tyr, Lys, Ile, 0.754; Ser, Gln, Cit, Tyr, Ile, Trp, 0.754; Ser, Gln, Arg, Tyr, Ile, Trp, 0.754; Ser, Gln, Pro, Tyr, Lys, Ile, 0.754; Ser, Gln, Tyr, Orn, Leu, Phe, 0.754; Asn, Gly, Gln, Pro, Tyr, Ile, 0.754; Asn, Gly, His, Tyr, Ile, Phe, 0.754; Asn, Gly, Thr, Tyr, Lys, Leu, 0.754; Asn, Gly, Thr, Lys, Ile, Leu, 0.754; Asn, Gly, Cit, Tyr, Lys, Leu, 0.754; Asn, Gly, Arg, Tyr, Val, Ile, 0.754; Asn, Gly, Arg, Tyr, Met, Ile, 0.754; Asn, Gly, Tyr, Leu, Phe, Trp, 0.754; Asn, Gln, His, Thr, Orn, Leu, 0.754; Asn, Gln, Thr, Val, Lys, Leu, 0.754; Asn, Gln, Thr, Orn, Leu, Phe, 0.754; Asn, Gln, Thr, Lys, Ile, Leu, 0.754; Asn, Gln, Thr, Lys, Ile, Phe, 0.754; Asn, Gln, Cit, Lys, Ile, Leu, 0.754; Asn, Gln, Tyr, Val, Ile, Trp, 0.754; Asn, Gln, Tyr, Orn, Ile, Leu, 0.754; Asn, Gln, Tyr, Lys, Ile, Trp, 0.754; Asn, Gln, Orn, Ile, Leu, Phe, 0.754; Asn, His, Thr, Cit, Tyr, Ile, 0.754; Asn, His, Ala, Arg, Lys, Ile, 0.754; Asn, His, Ala, Tyr, Ile, Leu, 0.754; Asn, His, Ala, Tyr, Ile, Phe, 0.754; Asn, His, Tyr, Met, Leu, Phe, 0.754; Asn, Thr, Met, Lys, Ile, Leu, 0.754; Asn, Cit, Pro, Tyr, Orn, Ile, 0.754; Asn, Cit, Pro, Lys, Ile, Trp, 0.754; Asn, Cit, Met, Orn, Lys, Ile, 0.754; Asn, Arg, Met, Lys, Ile, Leu, 0.754; Gly, Gln, His, Arg, Lys, Ile, 0.754; Gly, Gln, His, Tyr, Orn, Ile, 0.754; Gly, Gln, His, Val, Lys, Ile, 0.754; Gly, Gln, Thr, Pro, Tyr, Ile, 0.754; Gly, Gln, Ala, Cit, Tyr, Leu, 0.754; Gly, Gln, Ala, Tyr, Lys, Leu, 0.754; Gly, Gln, Cit, Arg, Orn, Ile, 0.754; Gly, Gln, Cit, Arg, Lys, Ile, 0.754; Gly, Gln, Cit, Lys, Ile, Phe, 0.754; Gly, Gln, Tyr, Val, Lys, Leu, 0.754; Gly, Gln, Tyr, Orn, Lys, Leu, 0.754; Gly, Thr, Cit, Tyr, Ile, Phe, 0.754; Gly, Cit, Tyr, Ile, Leu, Trp, 0.754; Gln, His, Thr, Ala, Ile, Trp, 0.754; Gln, His, Thr, Val, Met, Ile, 0.754; Gln, His, Thr, Ile, Leu, Phe, 0.754; Gln, His, Ala, Met, Orn, Ile, 0.754; Gln, His, Cit, Tyr, Val, Orn, 0.754; Gln, His, Cit, Tyr, Leu, Phe, 0.754; Gln, His, Arg, Tyr, Val, Orn, 0.754; Gln, His, Pro, Tyr, Lys, Ile, 0.754; Gln, His, Pro, Met, Ile, Phe, 0.754; Gln, His, Pro, Ile, Leu, Phe, 0.754; Gln, His, Lys, Ile, Leu, Phe, 0.754; Gln, Thr, Ala, Tyr, Ile, Leu, 0.754; Gln, Thr, Lys, Ile, Leu, Phe, 0.754; Gln, Cit, Arg, Ile, Leu, Phe, 0.754; Gln, Cit, Tyr, Val, Leu, Phe, 0.754; Gln, Cit, Tyr, Met, Orn, Ile, 0.754; Gln, Cit, Tyr, Met, Ile, Phe, 0.754; Gln, Cit, Tyr, Orn, Lys, Leu, 0.754; Gln, Cit, Tyr, Ile, Leu, Trp, 0.754; Gln, Arg, Tyr, Orn, Leu, Phe, 0.754; Gln, Arg, Val, Ile, Leu, Phe, 0.754; Gln, Tyr, Met, Lys, Leu, Trp, 0.754; Gln, Lys, Ile, Leu, Phe, Trp, 0.754; His, Thr, Pro, Tyr, Ile, Phe, 0.754; His, Thr, Tyr, Met, Ile, Trp, 0.754; His, Ala, Pro, Tyr, Ile, Phe, 0.754; His, Cit, Tyr, Met, Lys, Ile, 0.754; His, Cit, Tyr, Orn, Ile, Trp, 0.754; His, Pro, Tyr, Orn, Ile, Phe, 0.754; His, Pro, Tyr, Lys, Ile, Phe, 0.754; His, Pro, Tyr, Ile, Leu, Phe, 0.754; His, Tyr, Val, Met, Ile, Trp, 0.754; His, Tyr, Met, Orn, Ile, Trp, 0.754; Thr, Cit, Arg, Tyr, Lys, Ile, 0.754; Thr, Cit, Tyr, Lys, Ile, Trp, 0.754; Cit, Arg, Tyr, Val, Lys, Ile, 0.754; Arg, Pro, Tyr, Lys, Ile, Leu, 0.754; Arg, Tyr, Val, Lys, Ile, Leu, 0.754; Ser, Asn, Gln, His, Pro, Ile, 0.754; Ser, Asn, Gln, Orn, Lys, Ile, 0.754; Ser, Asn, Gln, Orn, Lys, Leu, 0.754; Ser, Asn, Gln, Lys, Ile, Leu, 0.754; Ser, Asn, His, Tyr, Ile, Leu, 0.754; Ser, Asn, His, Tyr, Ile, Phe, 0.754; Ser, Gly, Gln, His, Tyr, Ile, 0.754; Ser, Gly, Gln, His, Tyr, Leu, 0.754; Ser, Gln, His, Ala, Tyr, Leu, 0.754; Ser, Gln, His, Cit, Met, Ile, 0.754; Ser, Gln, His, Cit, Ile, Leu, 0.754; Ser, Gln, His, Arg, Val, Ile, 0.754; Ser, Gln, Ala, Tyr, Ile, Trp, 0.754; Ser, Gln, Cit, Tyr, Ile, Leu, 0.754; Ser, Gln, Tyr, Orn, Lys, Ile, 0.754; Ser, Thr, Tyr, Lys, Ile, Phe, 0.754; Asn, Gly, Gln, Ala, Tyr, Val, 0.754; Asn, Gly, His, Tyr, Val, Ile, 0.754; Asn, Gly, Ala, Cit, Lys, Ile, 0.754; Asn, Gly, Tyr, Met, Leu, Phe, 0.754; Asn, Gln, His, Thr, Ile, Trp, 0.754; Asn, Gln, His, Ala, Orn, Leu, 0.754; Asn, Gln, His, Tyr, Val, Lys, 0.754; Asn, Gln, His, Orn, Leu, Trp, 0.754; Asn, Gln, Ala, Lys, Ile, Leu, 0.754; Asn, Gln, Arg, Tyr, Ile, Phe, 0.754; Asn, Gln, Tyr, Val, Lys, Ile, 0.754; Asn, Gln, Val, Orn, Lys, Ile, 0.754; Asn, Gln, Val, Orn, Lys, Leu, 0.754; Asn, His, Arg, Pro, Ile, Phe, 0.754; Asn, His, Arg, Ile, Leu, Phe, 0.754; Asn, His, Pro, Tyr, Val, Ile, 0.754; Asn, His, Pro, Tyr, Ile, Phe, 0.754; Asn, His, Tyr, Orn, Lys, Ile, 0.754; Asn, His, Tyr, Lys, Ile, Trp, 0.754; Asn, His, Tyr, Lys, Leu, Phe, 0.754; Asn, Thr, Cit, Val, Lys, Ile, 0.754; Gly, Gln, His, Ala, Lys, Ile, 0.754; Gly, Gln, His, Cit, Val, Ile, 0.754; Gly, Gln, His, Tyr, Val, Ile, 0.754; Gly, Gln, His, Lys, Ile, Trp, 0.754; Gly, Gln, Thr, Arg, Tyr, Leu, 0.754; Gly, Gln, Thr, Tyr, Met, Ile, 0.754; Gly, Gln, Thr, Tyr, Lys, Leu, 0.754; Gly, Gln, Thr, Lys, Leu, Phe, 0.754; Gly, Gln, Ala, Pro, Tyr, Ile, 0.754; Gly, Gln, Cit, Orn, Ile, Phe, 0.754; Gly, Gln, Arg, Tyr, Met, Ile, 0.754; Gly, Gln, Arg, Tyr, Leu, Trp, 0.754; Gly, Gln, Val, Lys, Ile, Phe, 0.754; Gly, His, Ala, Tyr, Ile, Phe, 0.754; Gly, His, Tyr, Ile, Leu, Phe, 0.754; Gly, Cit, Tyr, Met, Ile, Phe, 0.754; Gly, Tyr, Met, Ile, Leu, Phe, 0.754; Gln, His, Thr, Pro, Met, Ile, 0.754; Gln, His, Thr, Met, Ile, Phe, 0.754; Gln, His, Ala, Arg, Pro, Ile, 0.754; Gln, His, Cit, Tyr, Orn, Leu, 0.754; Gln, His, Cit, Tyr, Lys, Leu, 0.754; Gln, His, Arg, Pro, Met, Ile, 0.754; Gln, His, Arg, Orn, Ile, Leu, 0.754; Gln, His, Arg, Orn, Ile, Trp, 0.754; Gln, His, Arg, Lys, Ile, Trp, 0.754; Gln, His, Pro, Val, Met, Ile, 0.754; Gln, His, Tyr, Val, Lys, Phe, 0.754; Gln, His, Val, Met, Ile, Trp, 0.754; Gln, Thr, Cit, Tyr, Leu, Phe, 0.754; Gln, Thr, Arg, Tyr, Ile, Leu, 0.754; Gln, Ala, Cit, Tyr, Orn, Ile, 0.754; Gln, Ala, Tyr, Met, Ile, Leu, 0.754; Gln, Cit, Arg, Tyr, Lys, Ile, 0.754; Gln, Cit, Tyr, Met, Leu, Phe, 0.754; Gln, Cit, Val, Ile, Leu, Phe, 0.754; Gln, Arg, Tyr, Met, Ile, Leu, 0.754; Gln, Arg, Tyr, Orn, Lys, Leu, 0.754; Gln, Arg, Tyr, Orn, Leu, Trp, 0.754; Gln, Arg, Tyr, Lys, Ile, Leu, 0.754; Gln, Arg, Met, Lys, Ile, Leu, 0.754; Gln, Arg, Ile, Leu, Phe, Trp, 0.754; Gln, Tyr, Val, Lys, Leu, Trp, 0.754; Gln, Tyr, Met, Orn, Lys, Ile, 0.754; Gln, Tyr, Met, Orn, Ile, Leu, 0.754; His, Thr, Tyr, Met, Orn, Ile, 0.754; His, Thr, Tyr, Orn, Ile, Phe, 0.754; His, Arg, Tyr, Met, Ile, Trp, 0.754; His, Arg, Tyr, Lys, Ile, Trp, 0.754; Thr, Tyr, Lys, Ile, Leu, Phe, 0.754; Arg, Tyr, Val, Orn, Lys, Trp, 0.754; Arg, Tyr, Met, Lys, Leu, Phe, 0.754; Arg, Val, Met, Lys, Ile, Phe, 0.754; Arg, Met, Orn, Lys, Ile, Phe, 0.754; Arg, Met, Lys, Ile, Phe, Trp, 0.754; Arg, Orn, Lys, Ile, Phe, Trp, 0.754; Tyr, Orn, Lys, Ile, Leu, Phe, 0.754; Ser, Asn, Gly, Gln, Lys, Ile, 0.753; Ser, Asn, Gln, His, Lys, Leu, 0.753; Ser, Asn, Thr, Tyr, Lys, Ile, 0.753; Ser, Asn, Arg, Tyr, Lys, Leu, 0.753; Ser, Asn, Tyr, Ile, Leu, Phe, 0.753; Ser, Gly, Gln, Tyr, Orn, Ile, 0.753; Ser, Gly, Gln, Val, Lys, Ile, 0.753; Ser, Gly, Gln, Lys, Ile, Phe, 0.753; Ser, Gln, His, Thr, Arg, Ile, 0.753; Ser, Gln, His, Ile, Leu, Phe, 0.753; Ser, Gln, Ala, Lys, Leu, Phe, 0.753; Ser, Gln, Pro, Tyr, Leu, Trp, 0.753; Ser, Gln, Tyr, Met, Ile, Trp, 0.753; Ser, Gln, Val, Lys, Ile, Trp, 0.753; Ser, His, Cit, Tyr, Met, Ile, 0.753; Ser, His, Arg, Lys, Ile, Phe, 0.753; Ser, Cit, Tyr, Lys, Ile, Trp, 0.753; Asn, Gly, Gln, Tyr, Met, Leu, 0.753; Asn, Gly, His, Arg, Lys, Ile, 0.753; Asn, Gly, His, Tyr, Ile, Leu, 0.753; Asn, Gly, Ala, Arg, Lys, Ile, 0.753; Asn, Gly, Cit, Tyr, Val, Leu, 0.753; Asn, Gly, Cit, Tyr, Leu, Trp, 0.753; Asn, Gly, 

Arg, Pro, Lys, Ile, 0.753; Asn, Gly, Pro, Tyr, Lys, Leu, 0.753; Asn, Gln, His, Ala, Tyr, Val, 0.753; Asn, Gln, His, Pro, Tyr, Lys, 0.753; Asn, Gln, His, Val, Orn, Leu, 0.753; Asn, Gln, His, Met, Orn, Leu, 0.753; Asn, Gln, Thr, Tyr, Leu, Trp, 0.753; Asn, Gln, Thr, Val, Lys, Ile, 0.753; Asn, Gln, Thr, Orn, Lys, Ile, 0.753; Asn, Gln, Ala, Tyr, Leu, Phe, 0.753; Asn, Gln, Ala, Tyr, Leu, Trp, 0.753; Asn, Gln, Ala, Val, Lys, Ile, 0.753; Asn, Gln, Ala, Orn, Lys, Ile, 0.753; Asn, Gln, Cit, Tyr, Leu, Trp, 0.753; Asn, Gln, Pro, Tyr, Lys, Leu, 0.753; Asn, Gln, Tyr, Orn, Lys, Ile, 0.753; Asn, Gln, Met, Lys, Ile, Phe, 0.753; Asn, Gln, Met, Lys, Ile, Trp, 0.753; Asn, Gln, Orn, Lys, Ile, Trp, 0.753; Asn, Gln, Lys, Leu, Phe, Trp, 0.753; Asn, His, Cit, Arg, Lys, Ile, 0.753; Asn, His, Arg, Ile, Phe, Trp, 0.753; Asn, His, Pro, Tyr, Ile, Trp, 0.753; Asn, His, Pro, Met, Lys, Ile, 0.753; Asn, His, Tyr, Val, Ile, Leu, 0.753; Asn, Cit, Pro, Lys, Ile, Leu, 0.753; Asn, Cit, Tyr, Lys, Leu, Trp, 0.753; Asn, Cit, Tyr, Ile, Leu, Trp, 0.753; Asn, Arg, Val, Lys, Ile, Trp, 0.753; Asn, Arg, Met, Lys, Ile, Trp, 0.753; Asn, Tyr, Val, Met, Leu, Phe, 0.753; Asn, Tyr, Met, Orn, Lys, Ile, 0.753; Asn, Tyr, Ile, Leu, Phe, Trp, 0.753; Asn, Val, Lys, Ile, Leu, Phe, 0.753; Gly, Gln, His, Thr, Ile, Phe, 0.753; Gly, Gln, His, Ala, Cit, Ile, 0.753; Gly, Gln, His, Arg, Tyr, Val, 0.753; Gly, Gln, His, Tyr, Val, Lys, 0.753; Gly, Gln, His, Met, Orn, Ile, 0.753; Gly, Gln, His, Orn, Lys, Ile, 0.753; Gly, Gln, His, Lys, Ile, Leu, 0.753; Gly, Gln, Thr, Tyr, Val, Ile, 0.753; Gly, Gln, Ala, Cit, Lys, Ile, 0.753; Gly, Gln, Cit, Lys, Ile, Trp, 0.753; Gly, Gln, Pro, Tyr, Lys, Leu, 0.753; Gly, Gln, Tyr, Val, Lys, Phe, 0.753; Gly, Gln, Orn, Lys, Ile, Trp, 0.753; Gly, Ala, Arg, Lys, Ile, Phe, 0.753; Gly, Cit, Tyr, Val, Ile, Trp, 0.753; Gly, Cit, Tyr, Met, Orn, Ile, 0.753; Gly, Arg, Orn, Lys, Ile, Phe, 0.753; Gln, His, Thr, Arg, Orn, Ile, 0.753; Gln, His, Thr, Val, Ile, Phe, 0.753; Gln, His, Ala, Arg, Ile, Leu, 0.753; Gln, His, Ala, Pro, Val, Ile, 0.753; Gln, His, Arg, Pro, Ile, Leu, 0.753; Gln, His, Arg, Met, Ile, Trp, 0.753; Gln, His, Arg, Lys, Ile, Leu, 0.753; Gln, His, Pro, Tyr, Lys, Leu, 0.753; Gln, His, Pro, Met, Ile, Leu, 0.753; Gln, His, Tyr, Val, Orn, Leu, 0.753; Gln, His, Met, Ile, Leu, Trp, 0.753; Gln, Thr, Cit, Tyr, Orn, Ile, 0.753; Gln, Thr, Lys, Ile, Leu, Trp, 0.753; Gln, Ala, Arg, Tyr, Lys, Ile, 0.753; Gln, Ala, Arg, Met, Lys, Ile, 0.753; Gln, Cit, Pro, Orn, Ile, Trp, 0.753; Gln, Cit, Tyr, Val, Orn, Ile, 0.753; Gln, Cit, Orn, Lys, Ile, Trp, 0.753; Gln, Cit, Lys, Ile, Leu, Phe, 0.753; Gln, Arg, Tyr, Met, Leu, Phe, 0.753; Gln, Arg, Tyr, Leu, Phe, Trp, 0.753; Gln, Pro, Tyr, Lys, Ile, Trp, 0.753; Gln, Pro, Tyr, Lys, Leu, Trp, 0.753; Gln, Val, Orn, Lys, Ile, Phe, 0.753; His, Thr, Tyr, Met, Lys, Ile, 0.753; His, Thr, Tyr, Ile, Leu, Phe, 0.753; Thr, Tyr, Orn, Ile, Leu, Phe, 0.753; Ala, Arg, Lys, Ile, Leu, Phe, 0.753; Cit, Arg, Pro, Tyr, Lys, Ile, 0.753; Arg, Val, Orn, Lys, Ile, Phe, 0.753; Ser, Asn, Gln, Arg, Tyr, Ile, 0.752; Ser, Asn, Gln, Met, Lys, Ile, 0.752; Ser, Asn, His, Tyr, Ile, Trp, 0.752; Ser, Asn, Cit, Pro, Tyr, Ile, 0.752; Ser, Asn, Cit, Tyr, Leu, Phe, 0.752; Ser, Gly, Gln, Arg, Tyr, Ile, 0.752; Ser, Gly, Gln, Tyr, Lys, Leu, 0.752; Ser, Gln, His, Tyr, Val, Trp, 0.752; Ser, Gln, His, Tyr, Met, Leu, 0.752; Ser, Gln, Thr, Lys, Ile, Trp, 0.752; Ser, Gln, Cit, Lys, Ile, Phe, 0.752; Ser, Gln, Tyr, Lys, Leu, Phe, 0.752; Ser, Gln, Val, Lys, Ile, Phe, 0.752; Ser, His, Tyr, Ile, Phe, Trp, 0.752; Ser, Thr, Arg, Lys, Ile, Phe, 0.752; Ser, Ala, Arg, Lys, Ile, Phe, 0.752; Asn, Gly, Gln, Arg, Orn, Leu, 0.752; Asn, Gly, Gln, Pro, Lys, Ile, 0.752; Asn, Gly, His, Tyr, Lys, Leu, 0.752; Asn, Gly, His, Met, Ile, Phe, 0.752; Asn, Gly, Ala, Tyr, Lys, Leu, 0.752; Asn, Gly, Arg, Pro, Tyr, Ile, 0.752; Asn, Gln, His, Ala, Orn, Lys, 0.752; Asn, Gln, His, Ala, Lys, Leu, 0.752; Asn, Gln, His, Pro, Lys, Ile, 0.752; Asn, Gln, His, Tyr, Lys, Phe, 0.752; Asn, Gln, Thr, Cit, Tyr, Leu, 0.752; Asn, Gln, Thr, Tyr, Lys, Leu, 0.752; Asn, Gln, Cit, Tyr, Met, Leu, 0.752; Asn, Gln, Arg, Tyr, Leu, Trp, 0.752; Asn, Gln, Arg, Lys, Leu, Phe, 0.752; Asn, Gln, Tyr, Val, Leu, Trp, 0.752; Asn, Gln, Tyr, Met, Orn, Leu, 0.752; Asn, Gln, Met, Lys, Ile, Leu, 0.752; Asn, Gln, Orn, Lys, Ile, Leu, 0.752; Asn, His, Thr, Arg, Ile, Phe, 0.752; Asn, His, Thr, Met, Ile, Phe, 0.752; Asn, His, Thr, Orn, Ile, Phe, 0.752; Asn, His, Ala, Pro, Tyr, Ile, 0.752; Asn, His, Cit, Val, Orn, Lys, 0.752; Asn, His, Arg, Pro, Tyr, Lys, 0.752; Asn, His, Pro, Lys, Ile, Phe, 0.752; Asn, His, Tyr, Val, Ile, Trp, 0.752; Asn, His, Met, Orn, Lys, Ile, 0.752; Asn, Thr, Cit, Tyr, Val, Ile, 0.752; Asn, Thr, Cit, Tyr, Ile, Phe, 0.752; Asn, Thr, Tyr, Met, Lys, Leu, 0.752; Asn, Ala, Cit, Val, Lys, Ile, 0.752; Asn, Cit, Arg, Pro, Lys, Ile, 0.752; Asn, Cit, Arg, Tyr, Ile, Phe, 0.752; Asn, Cit, Tyr, Met, Orn, Ile, 0.752; Asn, Cit, Tyr, Met, Leu, Phe, 0.752; Asn, Cit, Tyr, Orn, Lys, Leu, 0.752; Asn, Arg, Tyr, Orn, Leu, Phe, 0.752; Asn, Arg, Tyr, Ile, Leu, Phe, 0.752; Asn, Arg, Val, Met, Lys, Ile, 0.752; Asn, Pro, Tyr, Ile, Leu, Phe, 0.752; Asn, Tyr, Val, Ile, Leu, Phe, 0.752; Gly, Gln, His, Thr, Tyr, Leu, 0.752; Gly, Gln, His, Pro, Ile, Phe, 0.752; Gly, Gln, His, Lys, Leu, Phe, 0.752; Gly, Gln, Thr, Cit, Tyr, Leu, 0.752; Gly, Gln, Thr, Tyr, Val, Leu, 0.752; Gly, Gln, Thr, Lys, Ile, Trp, 0.752; Gly, Gln, Ala, Cit, Orn, Ile, 0.752; Gly, Gln, Cit, Val, Orn, Ile, 0.752; Gly, Gln, Arg, Tyr, Ile, Trp, 0.752; Gly, Gln, Tyr, Met, Orn, Ile, 0.752; Gly, Gln, Orn, Lys, Leu, Phe, 0.752; Gly, His, Thr, Tyr, Met, Ile, 0.752; Gly, His, Tyr, Met, Orn, Ile, 0.752; Gly, His, Tyr, Lys, Ile, Phe, 0.752; Gly, His, Tyr, Ile, Phe, Trp, 0.752; Gly, Ala, Cit, Tyr, Val, Ile, 0.752; Gly, Arg, Lys, Ile, Leu, Phe, 0.752; Gln, His, Thr, Ala, Arg, Ile, 0.752; Gln, His, Thr, Arg, Met, Ile, 0.752; Gln, His, Thr, Arg, Ile, Trp, 0.752; Gln, His, Thr, Pro, Ile, Leu, 0.752; Gln, His, Thr, Pro, Ile, Phe, 0.752; Gln, His, Thr, Met, Ile, Leu, 0.752; Gln, His, Arg, Tyr, Orn, Lys, 0.752; Gln, His, Arg, Val, Ile, Leu, 0.752; Gln, His, Arg, Met, Orn, Ile, 0.752; Gln, His, Pro, Met, Ile, Trp, 0.752; Gln, His, Tyr, Val, Met, Leu, 0.752; Gln, His, Met, Orn, Leu, Phe, 0.752; Gln, Thr, Arg, Tyr, Leu, Phe, 0.752; Gln, Thr, Pro, Tyr, Ile, Leu, 0.752; Gln, Ala, Arg, Val, Lys, Ile, 0.752; Gln, Ala, Arg, Lys, Ile, Leu, 0.752; Gln, Cit, Arg, Met, Lys, Ile, 0.752; Gln, Cit, Tyr, Val, Ile, Phe, 0.752; Gln, Cit, Tyr, Met, Lys, Ile, 0.752; Gln, Arg, Tyr, Met, Ile, Phe, 0.752; Gln, Pro, Tyr, Orn, Leu, Trp, 0.752; Gln, Tyr, Val, Orn, Leu, Trp, 0.752; Gln, Tyr, Met, Orn, Leu, Trp, 0.752; Gln, Val, Lys, Ile, Phe, Trp, 0.752; His, Cit, Tyr, Met, Ile, Trp, 0.752; His, Tyr, Lys, Ile, Phe, Trp, 0.752; Thr, Arg, Orn, Lys, Ile, Phe, 0.752; Thr, Pro, Tyr, Ile, Leu, Phe, 0.752; Cit, Arg, Tyr, Orn, Leu, Trp, 0.752; Cit, Tyr, Met, Ile, Leu, Phe, 0.752; Ser, Asn, Gln, Thr, Lys, Leu, 0.752; Ser, Asn, Gln, Arg, Lys, Leu, 0.752; Ser, Asn, Gln, Pro, Lys, Ile, 0.752; Ser, Asn, His, Arg, Ile, Phe, 0.752; Ser, Asn, His, Tyr, Orn, Ile, 0.752; Ser, Asn, Ala, Cit, Tyr, Ile, 0.752; Ser, Asn, Cit, Arg, Tyr, Ile, 0.752; Ser, Gly, Gln, His, Arg, Ile, 0.752; Ser, Gly, Gln, His, Tyr, Val, 0.752; Ser, Gly, Gln, Lys, Ile, Trp, 0.752; Ser, Gln, His, Thr, Cit, Ile, 0.752; Ser, Gln, His, Ala, Arg, Ile, 0.752; Ser, Gln, His, Ala, Ile, Phe, 0.752; Ser, Gln, His, Pro, Ile, Phe, 0.752; Ser, Gln, His, Met, Ile, Phe, 0.752; Ser, Gln, His, Lys, Ile, Phe, 0.752; Ser, Gln, Tyr, Val, Leu, Phe, 0.752; Ser, Gln, Tyr, Met, Ile, Leu, 0.752; Ser, Gln, Tyr, Lys, Leu, Trp, 0.752; Ser, Gln, Val, Met, Lys, Ile, 0.752; Ser, Gln, Lys, Ile, Leu, Phe, 0.752; Ser, Gln, Lys, Ile, Leu, Trp, 0.752; Ser, His, Ala, Tyr, Met, Ile, 0.752; Ser, His, Tyr, Orn, Ile, Phe, 0.752; Ser, Thr, Tyr, Ile, Leu, Phe, 0.752; Ser, Cit, Tyr, Ile, Leu, Phe, 0.752; Ser, Arg, Tyr, Lys, Leu, Phe, 0.752; Asn, Gly, Gln, Orn, Leu, Trp, 0.752; Asn, Gly, His, Ala, Tyr, Ile, 0.752; Asn, Gly, His, Tyr, Lys, Ile, 0.752; Asn, Gly, Thr, Tyr, Ile, Leu, 0.752; Asn, Gly, Cit, Arg, Tyr, Leu, 0.752; Asn, Gly, Tyr, Orn, Ile, Leu, 0.752; Asn, Gln, His, Arg, Tyr, Leu, 0.752; Asn, Gln, Thr, Lys, Leu, Trp, 0.752; Asn, Gln, Cit, Tyr, Met, Ile, 0.752; Asn, Gln, Cit, Val, Lys, Leu, 0.752; Asn, Gln, Pro, Lys, Leu, Phe, 0.752; Asn, Gln, Tyr, Met, Leu, Trp, 0.752; Asn, Gln, Val, Met, Lys, Ile, 0.752; Asn, Gln, Orn, Lys, Leu, Trp, 0.752; Asn, His, Cit, Arg, Orn, Ile, 0.752; Asn, His, Cit, Tyr, Leu, Phe, 0.752; Asn, His, Cit, Orn, Ile, Phe, 0.752; Asn, His, Arg, Tyr, Lys, Leu, 0.752; Asn, His, Arg, Met, Lys, Ile, 0.752; Asn, His, Arg, Lys, Ile, Leu, 0.752; Asn, His, Tyr, Val, Ile, Phe, 0.752; Asn, His, Tyr, Ile, Leu, Phe, 0.752; Asn, Thr, Ala, Cit, Lys, Ile, 0.752; Asn, Thr, Orn, Lys, Ile, Leu, 0.752; Asn, Ala, Cit, Tyr, Met, Ile, 0.752; Asn, Ala, Arg, Tyr, Lys, Leu, 0.752; Asn, Ala, Arg, Val, Lys, Ile, 0.752; Asn, Cit, Arg, Tyr, Orn, Ile, 0.752; Asn, Cit, Arg, Tyr, Lys, Leu, 0.752; Asn, Cit, Tyr, Val, Orn, Ile, 0.752; Asn, Cit, Tyr, Met, Lys, Leu, 0.752; Asn, Cit, Tyr, Orn, Ile, Leu, 0.752; Asn, Cit, Val, Lys, Ile, Phe, 0.752; Asn, Cit, Met, Lys, Ile, Phe, 0.752; Asn, Arg, Pro, Tyr, Lys, Leu, 0.752; Asn, Arg, Pro, Tyr, Lys, Phe, 0.752; Asn, Arg, Pro, Orn, Lys, Ile, 0.752; Asn, Arg, Tyr, Val, Lys, Trp, 0.752; Asn, Arg, Tyr, Val, Leu, Phe, 0.752; Asn, Tyr, Met, Orn, Leu, Phe, 0.752; Asn, Tyr, Met, Lys, Leu, Trp, 0.752; Gly, Gln, His, Thr, Met, Ile, 0.752; Gly, Gln, His, Val, Met, Ile, 0.752; Gly, Gln, Thr, Tyr, Val, Phe, 0.752; Gly, Gln, Thr, Tyr, Orn, Ile, 0.752; Gly, Gln, Ala, Cit, Arg, Ile, 0.752; Gly, Gln, Ala, Cit, Ile, Trp, 0.752; Gly, Gln, Cit, Tyr, Val, Leu, 0.752; Gly, Gln, Arg, Tyr, Orn, Ile, 0.752; Gly, Gln, Pro, Tyr, Met, Leu, 0.752; Gly, Gln, Tyr, Val, Ile, Trp, 0.752; Gly, Gln, Tyr, Orn, Ile, Phe, 0.752; Gly, His, Pro, Tyr, Ile, Phe, 0.752; Gly, Thr, Tyr, Ile, Leu, Phe, 0.752; Gly, Cit, Arg, Tyr, Ile, Phe, 0.752; Gly, Cit, Pro, Tyr, Val, Ile, 0.752; Gly, Cit, Tyr, Met, Lys, Ile, 0.752; Gly, Cit, Tyr, Orn, Ile, Phe, 0.752; Gly, Cit, Tyr, Ile, Phe, Trp, 0.752; Gly, Arg, Tyr, Lys, Leu, Phe, 0.752; Gly, Arg, Val, Lys, Ile, Phe, 0.752; Gln, His, Ala, Tyr, Orn, Leu, 0.752; Gln, His, Ala, Tyr, Leu, Phe, 0.752; Gln, His, Cit, Tyr, Leu, Trp, 0.752; Gl

n, His, Arg, Pro, Ile, Trp, 0.752; Gln, His, Arg, Val, Ile, Trp, 0.752; Gln, His, Arg, Orn, Leu, Phe, 0.752; Gln, His, Tyr, Met, Orn, Leu, 0.752; Gln, His, Orn, Leu, Phe, Trp, 0.752; Gln, His, Lys, Ile, Leu, Trp, 0.752; Gln, Thr, Cit, Val, Ile, Leu, 0.752; Gln, Thr, Tyr, Val, Ile, Leu, 0.752; Gln, Thr, Tyr, Orn, Ile, Leu, 0.752; Gln, Thr, Orn, Lys, Ile, Phe, 0.752; Gln, Thr, Orn, Lys, Ile, Trp, 0.752; Gln, Thr, Lys, Ile, Phe, Trp, 0.752; Gln, Ala, Cit, Arg, Lys, Ile, 0.752; Gln, Ala, Tyr, Val, Lys, Trp, 0.752; Gln, Ala, Val, Lys, Ile, Trp, 0.752; Gln, Cit, Pro, Tyr, Lys, Ile, 0.752; Gln, Cit, Tyr, Val, Lys, Ile, 0.752; Gln, Cit, Tyr, Met, Lys, Leu, 0.752; Gln, Cit, Tyr, Met, Ile, Leu, 0.752; Gln, Cit, Val, Lys, Ile, Phe, 0.752; Gln, Arg, Tyr, Val, Lys, Trp, 0.752; Gln, Arg, Tyr, Val, Leu, Phe, 0.752; Gln, Tyr, Val, Met, Ile, Trp, 0.752; Gln, Tyr, Val, Orn, Lys, Trp, 0.752; Gln, Tyr, Val, Lys, Ile, Leu, 0.752; Gln, Tyr, Met, Orn, Lys, Leu, 0.752; Gln, Orn, Ile, Leu, Phe, Trp, 0.752; His, Thr, Cit, Tyr, Met, Ile, 0.752; His, Thr, Tyr, Val, Ile, Phe, 0.752; His, Ala, Tyr, Orn, Ile, Phe, 0.752; His, Cit, Pro, Tyr, Met, Ile, 0.752; His, Arg, Lys, Ile, Phe, Trp, 0.752; His, Tyr, Val, Ile, Phe, Trp, 0.752; His, Tyr, Orn, Ile, Phe, Trp, 0.752; His, Tyr, Ile, Leu, Phe, Trp, 0.752; Thr, Ala, Arg, Lys, Ile, Phe, 0.752; Thr, Arg, Met, Lys, Ile, Phe, 0.752; Thr, Pro, Tyr, Met, Leu, Phe, 0.752; Thr, Pro, Tyr, Lys, Ile, Phe, 0.752; Thr, Tyr, Val, Ile, Leu, Phe, 0.752; Ala, Arg, Tyr, Lys, Ile, Leu, 0.752; Ala, Arg, Val, Lys, Ile, Phe, 0.752; Ala, Arg, Met, Lys, Ile, Phe, 0.752; Ala, Arg, Lys, Ile, Phe, Trp, 0.752; Cit, Arg, Tyr, Orn, Ile, Trp, 0.752; Cit, Tyr, Ile, Leu, Phe, Trp, 0.752; Ser, Asn, Gly, His, Tyr, Ile, 0.751; Ser, Asn, Gln, Ala, Lys, Ile, 0.751; Ser, Asn, Gln, Tyr, Ile, Trp, 0.751; Ser, Asn, Cit, Tyr, Ile, Phe, 0.751; Ser, Asn, Arg, Pro, Tyr, Lys, 0.751; Ser, Asn, Arg, Tyr, Leu, Phe, 0.751; Ser, Asn, Pro, Tyr, Leu, Phe, 0.751; Ser, Asn, Tyr, Leu, Phe, Trp, 0.751; Ser, Gly, Gln, Cit, Tyr, Leu, 0.751; Ser, Gly, Gln, Tyr, Val, Phe, 0.751; Ser, Gly, His, Tyr, Met, Ile, 0.751; Ser, Gly, Cit, Tyr, Ile, Phe, 0.751; Ser, Gln, Thr, Tyr, Lys, Leu, 0.751; Ser, Gln, Thr, Tyr, Ile, Trp, 0.751; Ser, Gln, Tyr, Val, Leu, Trp, 0.751; Ser, Gln, Met, Lys, Ile, Phe, 0.751; Ser, Gln, Met, Lys, Ile, Trp, 0.751; Ser, His, Arg, Tyr, Met, Ile, 0.751; Ser, His, Tyr, Met, Orn, Ile, 0.751; Ser, His, Tyr, Ile, Leu, Phe, 0.751; Ser, Arg, Val, Lys, Ile, Phe, 0.751; Ser, Arg, Lys, Ile, Leu, Phe, 0.751; Asn, Gly, Gln, Ala, Cit, Ile, 0.751; Asn, Gly, Gln, Val, Orn, Leu, 0.751; Asn, Gly, Gln, Ile, Leu, Phe, 0.751; Asn, Gly, His, Tyr, Ile, Trp, 0.751; Asn, Gly, Thr, Arg, Tyr, Ile, 0.751; Asn, Gly, Thr, Orn, Lys, Ile, 0.751; Asn, Gly, Ala, Pro, Tyr, Leu, 0.751; Asn, Gly, Ala, Tyr, Val, Leu, 0.751; Asn, Gln, His, Cit, Orn, Leu, 0.751; Asn, Gln, Thr, Cit, Tyr, Ile, 0.751; Asn, Gln, Thr, Cit, Lys, Ile, 0.751; Asn, Gln, Thr, Lys, Ile, Trp, 0.751; Asn, Gln, Ala, Tyr, Ile, Trp, 0.751; Asn, Gln, Ala, Orn, Lys, Leu, 0.751; Asn, Gln, Cit, Tyr, Val, Leu, 0.751; Asn, Gln, Cit, Tyr, Ile, Trp, 0.751; Asn, Gln, Arg, Orn, Lys, Leu, 0.751; Asn, Gln, Pro, Tyr, Leu, Trp, 0.751; Asn, His, Thr, Met, Lys, Ile, 0.751; Asn, His, Ala, Cit, Ile, Leu, 0.751; Asn, His, Ala, Lys, Ile, Phe, 0.751; Asn, His, Cit, Pro, Ile, Phe, 0.751; Asn, His, Arg, Met, Ile, Phe, 0.751; Asn, His, Pro, Tyr, Lys, Ile, 0.751; Asn, His, Tyr, Orn, Ile, Leu, 0.751; Asn, His, Tyr, Lys, Ile, Leu, 0.751; Asn, His, Val, Ile, Phe, Trp, 0.751; Asn, His, Met, Lys, Ile, Leu, 0.751; Asn, Thr, Cit, Lys, Ile, Phe, 0.751; Asn, Thr, Arg, Tyr, Leu, Phe, 0.751; Asn, Thr, Val, Lys, Ile, Leu, 0.751; Asn, Ala, Cit, Arg, Lys, Ile, 0.751; Asn, Ala, Arg, Lys, Ile, Trp, 0.751; Asn, Cit, Arg, Tyr, Met, Ile, 0.751; Asn, Arg, Tyr, Val, Lys, Leu, 0.751; Gly, Gln, His, Ala, Pro, Ile, 0.751; Gly, Gln, His, Ala, Val, Ile, 0.751; Gly, Gln, His, Cit, Lys, Ile, 0.751; Gly, Gln, His, Arg, Val, Ile, 0.751; Gly, Gln, His, Arg, Orn, Ile, 0.751; Gly, Gln, Thr, Arg, Tyr, Ile, 0.751; Gly, Gln, Thr, Met, Lys, Ile, 0.751; Gly, Gln, Cit, Tyr, Orn, Leu, 0.751; Gly, Gln, Cit, Tyr, Lys, Ile, 0.751; Gly, Gln, Cit, Orn, Ile, Trp, 0.751; Gly, Gln, Cit, Lys, Ile, Leu, 0.751; Gly, Gln, Pro, Tyr, Met, Ile, 0.751; Gly, Gln, Val, Lys, Ile, Trp, 0.751; Gly, Gln, Met, Orn, Lys, Ile, 0.751; Gly, His, Cit, Tyr, Val, Ile, 0.751; Gly, Thr, Tyr, Lys, Ile, Phe, 0.751; Gly, Cit, Pro, Tyr, Lys, Ile, 0.751; Gly, Cit, Tyr, Lys, Ile, Phe, 0.751; Gly, Arg, Tyr, Val, Met, Lys, 0.751; Gly, Tyr, Val, Met, Ile, Phe, 0.751; Gly, Tyr, Ile, Leu, Phe, Trp, 0.751; Gln, His, Thr, Ala, Val, Ile, 0.751; Gln, His, Thr, Arg, Pro, Ile, 0.751; Gln, His, Thr, Arg, Val, Ile, 0.751; Gln, His, Thr, Met, Ile, Trp, 0.751; Gln, His, Ala, Arg, Orn, Ile, 0.751; Gln, His, Ala, Pro, Tyr, Leu, 0.751; Gln, His, Ala, Tyr, Lys, Ile, 0.751; Gln, His, Ala, Met, Ile, Leu, 0.751; Gln, His, Ala, Lys, Ile, Trp, 0.751; Gln, His, Cit, Pro, Lys, Ile, 0.751; Gln, His, Arg, Pro, Tyr, Lys, 0.751; Gln, His, Arg, Met, Ile, Leu, 0.751; Gln, His, Arg, Ile, Leu, Trp, 0.751; Gln, His, Pro, Met, Orn, Ile, 0.751; Gln, His, Pro, Lys, Ile, Phe, 0.751; Gln, His, Tyr, Val, Phe, Trp, 0.751; Gln, His, Val, Ile, Leu, Trp, 0.751; Gln, Thr, Ala, Arg, Lys, Ile, 0.751; Gln, Thr, Arg, Tyr, Ile, Phe, 0.751; Gln, Thr, Val, Lys, Ile, Trp, 0.751; Gln, Ala, Cit, Val, Ile, Leu, 0.751; Gln, Ala, Pro, Tyr, Leu, Phe, 0.751; Gln, Ala, Tyr, Orn, Leu, Trp, 0.751; Gln, Cit, Pro, Tyr, Orn, Ile, 0.751; Gln, Cit, Orn, Ile, Leu, Phe, 0.751; Gln, Cit, Lys, Ile, Leu, Trp, 0.751; Gln, Cit, Lys, Ile, Phe, Trp, 0.751; Gln, Arg, Pro, Lys, Ile, Phe, 0.751; Gln, Pro, Tyr, Val, Lys, Trp, 0.751; Gln, Pro, Tyr, Met, Ile, Leu, 0.751; Gln, Val, Lys, Ile, Leu, Trp, 0.751; Gln, Orn, Lys, Ile, Phe, Trp, 0.751; His, Thr, Ala, Tyr, Met, Ile, 0.751; His, Thr, Arg, Tyr, Met, Ile, 0.751; His, Thr, Arg, Tyr, Lys, Ile, 0.751; His, Thr, Pro, Tyr, Met, Ile, 0.751; Thr, Cit, Arg, Tyr, Ile, Phe, 0.751; Thr, Arg, Tyr, Val, Lys, Ile, 0.751; Thr, Arg, Lys, Ile, Phe, Trp, 0.751; Thr, Tyr, Met, Lys, Leu, Phe, 0.751; Thr, Tyr, Ile, Leu, Phe, Trp, 0.751; Ala, Cit, Tyr, Ile, Leu, Phe, 0.751; Cit, Tyr, Val, Lys, Ile, Trp, 0.751; Arg, Pro, Tyr, Met, Orn, Lys, 0.751; Tyr, Lys, Ile, Leu, Phe, Trp, 0.751; Ser, Asn, Gln, Tyr, Orn, Ile, 0.75; Ser, Asn, Lys, Ile, Leu, Phe, 0.75; Ser, Gly, Gln, His, Cit, Ile, 0.75; Ser, Gly, His, Arg, Tyr, Ile, 0.75; Ser, Gly, Cit, Tyr, Met, Ile, 0.75; Ser, Gln, His, Arg, Ile, Leu, 0.75; Ser, Gln, His, Pro, Tyr, Leu, 0.75; Ser, Gln, His, Tyr, Val, Leu, 0.75; Ser, Gln, His, Val, Lys, Ile, 0.75; Ser, Gln, Ala, Tyr, Leu, Trp, 0.75; Ser, Gln, Cit, Tyr, Val, Ile, 0.75; Ser, Gln, Cit, Tyr, Orn, Ile, 0.75; Ser, Gln, Tyr, Met, Leu, Trp, 0.75; Ser, His, Pro, Tyr, Met, Ile, 0.75; Ser, Cit, Tyr, Val, Orn, Ile, 0.75; Ser, Arg, Orn, Lys, Ile, Phe, 0.75; Asn, Gly, Ala, Arg, Tyr, Ile, 0.75; Asn, Gly, Tyr, Val, Leu, Phe, 0.75; Asn, Gln, Val, Lys, Ile, Trp, 0.75; Asn, Thr, Cit, Tyr, Met, Ile, 0.75; Asn, Thr, Arg, Pro, Lys, Ile, 0.75; Asn, Thr, Val, Met, Lys, Ile, 0.75; Asn, Ala, Cit, Met, Lys, Ile, 0.75; Asn, Ala, Cit, Lys, Ile, Trp, 0.75; Asn, Ala, Tyr, Lys, Leu, Trp, 0.75; Asn, Cit, Orn, Lys, Ile, Trp, 0.75; Asn, Arg, Pro, Lys, Ile, Leu, 0.75; Gly, Gln, His, Arg, Pro, Ile, 0.75; Gly, Gln, Thr, Lys, Ile, Phe, 0.75; Gly, Gln, Ala, Tyr, Orn, Ile, 0.75; Gly, Thr, Tyr, Lys, Leu, Phe, 0.75; Gly, Cit, Tyr, Val, Met, Ile, 0.75; Gly, Tyr, Lys, Ile, Leu, Phe, 0.75; Gln, His, Cit, Arg, Lys, Ile, 0.75; Gln, His, Pro, Val, Ile, Trp, 0.75; Gln, His, Val, Lys, Ile, Trp, 0.75; Gln, His, Met, Orn, Ile, Trp, 0.75; Gln, Thr, Ala, Tyr, Leu, Phe, 0.75; Gln, Thr, Cit, Ile, Leu, Phe, 0.75; Gln, Thr, Tyr, Val, Lys, Leu, 0.75; Gln, Cit, Tyr, Met, Orn, Leu, 0.75; Gln, Arg, Pro, Tyr, Ile, Phe, 0.75; Gln, Pro, Tyr, Val, Ile, Trp, 0.75; Gln, Tyr, Val, Orn, Ile, Leu, 0.75; His, Arg, Orn, Ile, Leu, Phe, 0.75; Thr, Ala, Tyr, Lys, Ile, Phe, 0.75; Ala, Arg, Tyr, Lys, Leu, Trp, 0.75; Arg, Pro, Orn, Lys, Ile, Phe, 0.75; Arg, Tyr, Orn, Lys, Leu, Phe, 0.75; Tyr, Met, Ile, Leu, Phe, Trp, 0.75; Ser, Asn, Gln, Pro, Tyr, Ile, 0.75; Ser, Asn, Gln, Met, Lys, Leu, 0.75; Ser, Asn, His, Lys, Ile, Trp, 0.75; Ser, Asn, Thr, Tyr, Ile, Leu, 0.75; Ser, Asn, Arg, Val, Lys, Ile, 0.75; Ser, Gln, His, Thr, Ile, Phe, 0.75; Ser, Gln, His, Cit, Lys, Ile, 0.75; Ser, Gln, Thr, Lys, Leu, Phe, 0.75; Ser, Gln, Arg, Tyr, Ile, Leu, 0.75; Ser, Gln, Arg, Tyr, Leu, Phe, 0.75; Ser, Gln, Tyr, Val, Lys, Trp, 0.75; Ser, His, Tyr, Met, Ile, Leu, 0.75; Ser, Thr, Cit, Tyr, Ile, Phe, 0.75; Ser, Thr, Arg, Lys, Ile, Trp, 0.75; Ser, Arg, Tyr, Ile, Leu, Trp, 0.75; Ser, Arg, Met, Lys, Ile, Trp, 0.75; Ser, Tyr, Met, Ile, Leu, Phe, 0.75; Asn, Gly, Gln, His, Orn, Leu, 0.75; Asn, Gly, Gln, Cit, Pro, Ile, 0.75; Asn, Gly, Gln, Tyr, Val, Trp, 0.75; Asn, Gly, His, Cit, Tyr, Leu, 0.75; Asn, Gly, Thr, Tyr, Met, Leu, 0.75; Asn, Gly, Thr, Val, Lys, Ile, 0.75; Asn, Gly, Thr, Met, Lys, Ile, 0.75; Asn, Gly, Lys, Ile, Leu, Phe, 0.75; Asn, Gln, Thr, Arg, Leu, Phe, 0.75; Asn, Gln, Ala, Cit, Ile, Leu, 0.75; Asn, Gln, Cit, Arg, Tyr, Ile, 0.75; Asn, Gln, Cit, Pro, Tyr, Ile, 0.75; Asn, His, Ala, Arg, Ile, Phe, 0.75; Asn, His, Arg, Tyr, Orn, Leu, 0.75; Asn, His, Arg, Tyr, Leu, Phe, 0.75; Asn, His, Pro, Tyr, Orn, Ile, 0.75; Asn, His, Pro, Tyr, Ile, Leu, 0.75; Asn, His, Tyr, Val, Orn, Ile, 0.75; Asn, His, Tyr, Val, Lys, Ile, 0.75; Asn, His, Tyr, Met, Lys, Leu, 0.75; Asn, His, Val, Met, Lys, Ile, 0.75; Asn, His, Met, Ile, Phe, Trp, 0.75; Asn, Thr, Lys, Ile, Leu, Trp, 0.75; Asn, Cit, Pro, Tyr, Met, Ile, 0.75; Asn, Arg, Tyr, Val, Orn, Lys, 0.75; Gly, Gln, His, Arg, Met, Ile, 0.75; Gly, Gln, His, Arg, Ile, Trp, 0.75; Gly, Gln, His, Met, Lys, Ile, 0.75; Gly, Gln, Thr, Orn, Lys, Ile, 0.75; Gly, Gln, Ala, Tyr, Orn, Leu, 0.75; Gly, Gln, Cit, Pro, Tyr, Leu, 0.75; Gly, Gln, Pro, Tyr, Val, Ile, 0.75; Gly, Gln, Tyr, Val, Met, Phe, 0.75; Gly, Gln, Met, Lys, Ile, Trp, 0.75; Gly, Thr, Cit, Tyr, Met, Ile, 0.75; Gly, Ala, Cit, Tyr, Ile, Phe, 0.75; Gln, His, Thr, Arg, Ile, Leu, 0.75; Gln, His, Ala, Cit, Lys, Ile, 0.75; Gln, His, Ala, Tyr, Val, Leu, 0.75; Gln, His, Ala, Lys, Ile, Phe, 0.75; Gln, His, Arg, Val, Met, Ile, 0.75; Gln, His, Pro, Tyr, Val, Trp, 0.75; Gln, Thr, Arg, Lys, Ile, Leu, 0.75; Gln, Thr, Tyr, Met, Ile, Leu,0

.75; Gln, Thr, Tyr, Orn, Leu, Trp, 0.75; Gln, Thr, Val, Lys, Leu, Phe, 0.75; Gln, Ala, Cit, Val, Lys, Ile, 0.75; Gln, Ala, Tyr, Val, Ile, Trp, 0.75; Gln, Ala, Tyr, Orn, Leu, Phe, 0.75; Gln, Cit, Tyr, Met, Leu, Trp, 0.75; Gln, Cit, Tyr, Orn, Lys, Ile, 0.75; Gln, Arg, Tyr, Met, Orn, Leu, 0.75; Gln, Pro, Tyr, Met, Ile, Trp, 0.75; Gln, Tyr, Orn, Lys, Leu, Trp, 0.75; Gln, Met, Lys, Ile, Leu, Trp, 0.75; Gln, Met, Lys, Ile, Phe, Trp, 0.75; His, Cit, Pro, Tyr, Lys, Ile, 0.75; His, Arg, Met, Lys, Ile, Leu, 0.75; His, Arg, Lys, Ile, Leu, Phe, 0.75; Thr, Arg, Tyr, Lys, Leu, Phe, 0.75; Thr, Arg, Val, Lys, Ile, Phe, 0.75; Thr, Tyr, Lys, Leu, Phe, Trp, 0.75; Ala, Cit, Arg, Lys, Ile, Phe, 0.75; Ala, Arg, Orn, Lys, Ile, Phe, 0.75; Ala, Tyr, Lys, Ile, Leu, Phe, 0.75; Arg, Pro, Tyr, Lys, Leu, Phe, 0.75 [5. Six-variable formula including amino acids]
Gln, His, Tyr, Ile, Phe, Trp, 0.785; Asn, Gly, Gln, Tyr, Leu, Phe, 0.78; Gln, His, Arg, Tyr, Ile, Phe, 0.78; Asn, Gln, His, Cit, Orn, Ile, 0.78; Gln, His, Tyr, Met, Ile, Phe, 0.78; Asn, Arg, Tyr, Lys, Ile, Phe, 0.779; Asn, Gly, Arg, Tyr, Lys, Ile, 0.778; Arg, Tyr, Met, Lys, Ile, 0.778; Gln, His, Tyr, Orn, Ile, Phe, 0.778; Gln, His, Tyr, Ile, Leu, Phe, 0.778; Phe, 0.778; His, Arg, Tyr, Lys, Ile, Phe, 0.778; Asn, Gln, His, Tyr, Ile, Trp, 0.777; Gly, Arg, Tyr, Lys, Ile, Phe, 0.777; Lys, Ile, Phe, Trp, 0.777; Ser, Gln, His, Tyr, Ile, Phe, 0.777; Asn, Gln, His, Tyr, Ile, Phe, 0.777; Gln, His, Ala, Tyr, Ile, Phe, Gln, His, Tyr, Val, Ile, Phe, 0.777; Gln, Tyr, Lys, Ile, Leu, Phe, 0.777; Arg, Tyr, Lys, Ile, Leu, Phe, 0.777; Ser, Gln, His, Tyr, Ile, Trp, 0.776; Gly, Gln, His, Tyr, Met, Ile, 0.776; Gly, Gln, His, Tyr, Ile, Phe, 0.776; Arg, Tyr, Orn, Lys, Ile, Phe, 0.776; Asn, Gly, Gln, His, Tyr, Ile, 0.775; Gly, Gln, His, Tyr, Ile, Trp, 0.775; Gln, Tyr, Ile, Leu, Phe, 0.775; Gln, Tyr, Ile, Leu, Phe, Trp, 0.775; Ser, Asn, Gln, His, Tyr, Ile, 0.775; Ser, Arg, Tyr, Lys, Ile, Phe, 0.775; Asn, Gln, His, Cit, Ile, Phe, 0.775; Asn, Gln, His, Lys, Ile, Phe, 0.775; Gln, His, Thr, Tyr, Ile, Phe, 0.775; Cit, Orn, Ile, Phe, 0.775; Gln, His, Pro, Tyr, Ile, Phe, 0.775; Gln, His, Tyr, Lys, Ile, Phe, 0.775; Arg, Tyr, Val, Lys, Ile, Phe, Asn, Gln, His, Tyr, Met, Ile, 0.774; Gln, His, Tyr, Leu, Phe, Trp, 0.774; Arg, Tyr, Met, Lys, Ile, Trp, 0.774; Ser, Asn, Arg, Tyr, Lys, Ile, 0.773; Asn, Cit, Arg, Tyr, Lys, Ile, 0.773; Asn, Arg, Tyr, Lys, Ile, Trp, 0.773; Gln, His, Cit, Tyr, Ile, Phe, 0.773; Asn, Gln, Arg, Tyr, Lys, Ile, 0.773; Asn, Gln, Tyr, Ile, Leu, Phe, 0.773; Asn, His, Arg, Tyr, Lys, Ile, 0.773; Gly, Arg, Tyr, Met, Lys, Ile, 0.773; Gln, His, Arg, Tyr, Orn, Ile, 0.772; Gln, Pro, Tyr, Lys, Ile, Phe, 0.772; Gln, Tyr, Met, Lys, Ile, Phe, 0.772; Tyr, Met, Lys, Ile, Phe, 0.772; Ser, Gln, Tyr, Lys, Ile, Phe, 0.771; Asn, G ln, His, Tyr, Orn, Ile, 0.771; Asn, Gln, His, Val, Ile, Phe, 0.771; Gly, Gln, Arg, Tyr, Lys, Ile, 0.771; Gly, Gln, Tyr, Leu, Phe, Trp, 0.771; Thr, Arg, Tyr, Lys, Ile, Phe, 0.771; Asn, Gln, His, Thr, Tyr, Ile, 0.771; Asn, Gln, His, Ala, Cit, Ile, 0.771; His, Cit, Arg, Ile, 0.771; Asn, Gln, Tyr, Lys, Ile, Phe, 0.771; Gly, Gln, His, Tyr, Leu, Phe, 0.771; Gln, His, Cit, Tyr, Orn, Ile, Gln, His, Cit, Tyr, Ile, Trp, 0.771; Gln, Arg, Tyr, Ile, Leu, Phe, 0.771; Ser, Gln, Tyr, Met, Ile, Phe, 0.77; Asn, Gln, His, Cit, Pro, Ile, 0.77; Asn, Gln, His, Arg, Ile, Phe, 0.77; Asn, Gln, His, Pro, Tyr, Ile, 0.77; Asn, Gln, His, Tyr, Ile, Leu, 0.77; Gln, His, Ala, Tyr, Ile, Trp, 0.77; Gln, His, Cit, Arg, Ile, Phe, 0.77; Gln, His, Cit, Pro, Orn, Ile, 0.77; Leu, Phe, 0.77; Gln, Arg, Tyr, Lys, Ile, Phe, 0.77; Ala, Arg, Tyr, Lys, Ile, Phe, 0.77; Cit, Arg, Tyr, Lys, Ile, Phe, 0.77; Gln, Tyr, Ile, Leu, Phe, 0.77; Asn, Gln, His, Cit, Ile, Trp, 0.77; Asn, Gln, His, Arg, T yr, Ile, 0.77; Asn, Gln, His, Met, Ile, Phe, 0.77; Asn, Gln, Arg, Orn, Lys, Ile, 0.77; Asn, Arg, Tyr, Val, Lys, Ile, 0.77; Arg, Tyr, Orn, Lys, Ile, 0.77; Gly, Gln, His, Cit, Ile, Phe, 0.77; Gly, Gln, Tyr, Met, Ile, Phe, 0.77; Ile, 0.77; Gln, His, Cit, Ile, Leu, Phe, 0.77; Gln, His, Arg, Tyr, Ile, Trp, 0.77; Gln, His, Tyr, Met, Ile, Trp, 0.77; Tyr, Orn, Ile, Trp, 0.77; Gln, His, Tyr, Orn, Leu, Phe, 0.77; Gln, His, Tyr, Ile, Leu, Trp, 0.77; Gln, Pro, Tyr, Ile, Leu, Phe, Gln, Tyr, Val, Lys, Ile, Phe, 0.77; Asn, Gln, His, Ala, Tyr, Ile, 0.769; Asn, Gln, His, Tyr, Val, Ile, 0.769; Asn, Gln, His, Ile, Leu, Phe, 0.769; Asn, Gln, His, Ile, Phe, Trp, 0.769; Asn, Ala, Arg, Tyr, Lys, Ile, 0.769; Asn, Arg, Tyr, Lys, Ile, Leu, 0.769; Gly, Gln, His, Tyr, Val, Trp, 0.769; Gly, Gln, Tyr, Met, Leu, Phe, 0.769; Gln, His, Ala, Arg, Tyr, Ile, 0.769; Orn, Ile, 0.769; Gln, His, Cit, Orn, Ile, Leu, 0.769; Gln, Tyr, Lys, Leu, Phe, Trp, 0.769; er, Gln, His, Tyr, Met, Ile, 0.768; Asn, Gly, Gln, Cit, Tyr, Ile, 0.768; Asn, Gly, Gln, Tyr, Lys, Leu, 0.768; Ile, Leu, 0.768; Asn, Gln, His, Orn, Ile, Phe, 0.768; Asn, Thr, Arg, Tyr, Lys, Ile, 0.768; Asn, Arg, Pro, Tyr, Lys, Ile, 0.768; His, Cit, Pro, Ile, Phe, 0.768; Gln, His, Cit, Ile, Phe, Trp, 0.768; Gln, Tyr, Val, Ile, Phe, Trp, 0.768; Gln, Tyr, Orn, Ile, Leu, Phe, 0.768; Ser, Gln, His, Cit, Orn, Ile, 0.768; Ser, Gln, Tyr, Ile, Phe, Trp, 0.768; Asn, Gly, Gln, His, Tyr, Leu, 0.768; Arg, Tyr, Lys, Leu, 0.768; Asn, Gln, His, Cit, Val, Ile, 0.768; Asn, Gln, His, Val, Lys, Ile, 0.768; Asn, Gln, Arg, Lys, Ile, Phe, Asn, Gln, Tyr, Leu, Phe, Trp, 0.768; Asn, His, Arg, Lys, Ile, Phe, 0.768; Asn, Cit, Tyr, Met, Lys, Ile, 0.768; Asn, Cit, Tyr, Lys, Ile, Trp, 0.768; Gly, Gln, His, Cit, Orn, Ile, 0.768; Gly, Gln, Tyr, Val, Leu, Phe, 0.768; Gly, Gln, Tyr, Met, Lys, Ile, 0.768; Gln, His, Cit, Pro, Val, Ile, 0.768; Gln, His, Cit, Val, Ile, Phe, 0.768; n, His, Arg, Lys, Ile, Phe, 0.768; His, Arg, Tyr, Met, Lys, Ile, 0.768; Ser, Asn, Gln, Tyr, Leu, Phe, 0.767; Ser, Gln, Arg, Tyr, Lys, Ile, 0.767; Asn, Gln, His, Thr, Ile, Phe, 0.767; Asn, Gln, His, Ala, Ile, Trp, 0.767; Asn, Gln, His, Pro, Val, Ile, 0.767; Gln, Tyr, Met, Leu, Phe, 0.767; Asn, Gln, Tyr, Lys, Leu, Phe, 0.767; Asn, His, Tyr, Met, Lys, Ile, 0.767; Gly, Gln, Pro, Tyr, Leu, Phe, 0.767; Gln, His, Ala, Tyr, Orn, Ile, 0.767; Gln, His, Cit, Arg, Orn, Ile, 0.767; Gln, His, Cit, Met, Orn, Ile, 0.767; Arg, Pro, Tyr, Ile, 0.767; Gln, His, Tyr, Met, Orn, Ile, 0.767; Gln, Tyr, Val, Ile, Leu, Phe, 0.767; Ser, Gln, Tyr, Orn, Ile, Phe, 0.766; Asn, Gly, Gln, His, Cit, Ile, 0.766; Asn, Gly, Gln, His, Ile, Phe, 0.766; Asn, Gly, Gln, Lys, Ile, Leu, 0.766; Asn, Gly, His, Tyr, Met, Ile, 0.766; Asn, Gln, His, Pro, Ile, Phe, 0.766; Asn, Gln, Cit, Tyr, Leu, Phe, 0.766; Asn, Cit, Tyr, Ile, Leu, Phe, 0.766; Gly, Gln, Thr, Tyr, Leu, Phe, 0.766; , Gln, Ala, Tyr, Ile, Phe, 0.766; Gly, Gln, Pro, Tyr, Ile, Phe, 0.766; Gly, Gln, Tyr, Lys, Ile, Phe, 0.766; Gln, His, Thr, Arg, Tyr, Ile, 0.766; Gln, His, Ala, Cit, Pro, Ile, 0.766; Gln, His, Cit, Met, Ile, Phe, 0.766; , Tyr, Val, Ile, Trp, 0.766; Gln, Thr, Tyr, Lys, Ile, Phe, 0.766; Gln, Arg, Tyr, Lys, Leu, Phe, 0.766; Ser, Gln, Pro, Tyr, Ile, Phe Asn, Gln, His, Thr, Ala, Ile, 0.766; 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Ser, Gln, Ala , Tyr, Ile, Phe, 0.763; Ser, Gln, Arg, Val, Lys, Ile, 0.763; Ser, Gln, Arg, Lys, Ile, Phe, 0.763; Ser, Gln, Tyr, Leu, Phe, Trp, 0.763 Ser, Thr, Arg, Tyr, Lys, Ile, 0.763; Ser, Arg, Tyr, Lys, Ile, Leu, 0.763; Asn, Gly, Gln, His, Val, Ile, 0.763; Asn, Gly, Gln, Thr Asn, Gly, Gln, Lys, Leu, Phe, 0.763; Asn, Gly, Cit, Lys, Ile, Leu, 0.763; Asn, Gly, Gln, Lys, Leu, Phe, 0.763; , Gln, His, Thr, Val, Ile, 0.763; Asn, Gln, His, Ala, Ile, Phe, 0.763; Asn, Gln, Thr, Tyr, Leu, Phe, 0.763; , Phe, 0.763; Asn, Gln, Tyr, Lys, Leu, Trp, 0.763; Asn, Thr, Arg, Lys, Ile, Phe, 0.763; Asn, Ala, Cit, Tyr, Lys, Ile, 0.763; , Orn, Lys, Ile, Phe, 0.763; Gly, Gln, His, Pro, Tyr, Ile, 0.763; Gly, Gln, Cit, Pro, Orn, Ile, 0.763; Gly, Gln, Cit, Tyr, Ile, Phe , 0.763; Gly, Gln, Pro, Tyr, Leu, Trp, 0.763; Gly, Gln, Tyr, Met, Ile, Leu, Gln, His, Ala, Cit, Ile, Phe, 0.763; Gln, His, Ala, Pro, Tyr, Ile, 0.763; Gln, His, Cit, Tyr, Ile, Leu, 0.763; Gln, Thr, Arg, Lys, Ile, Phe, 0.763; Gln, Ala, Tyr, Met, Ile, Phe, 0.763; 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Ser, Asn, Thr, Arg, Lys, Ile, 0.76; Ser, Asn, Arg, Lys, Ile, Trp Ser, Gly, Gln, Tyr, Ile, Leu, 0.76; Ser, Gln, His, Thr, Tyr, Ile, 0.76; Ser, Gln, Thr, Arg, Lys, Ile, 0.76; Ser, Gln, Arg , Orn, Lys, Ile, 0.76; Ser, Gln, Tyr, Orn, Leu, Trp, 0.76; Asn, Gly, Gln, Cit, Lys, Ile, 0.76; Asn, Gly, Gln, Arg, Lys, Ile, 0.76 Asn, Gly, Gln, Lys, Ile, Trp, 0.76; Asn, Gly, His, Arg, Tyr, Ile, 0.76; Asn, Gly, Cit , Tyr, Lys, Ile, 0.76; Asn, Gly, Arg, Pro, Tyr, Lys, 0.76; Asn, Gln, Thr, Tyr, Ile, Phe, 0.76; Asn, Gln, Cit, Val, Lys, Ile, 0.76 Asn, Gln, Pro, Tyr, Lys, Ile, 0.76; Asn, Gln, Tyr, Val, Ile, Leu, 0.76; Asn, Gln, Orn, Lys, Ile, Phe, 0.76;

n, His, Ala, Cit, Lys, Ile, 0.76; Asn, His, Cit, Tyr, Val, Ile, 0.76; Asn, His, Cit, Met, Lys, Ile, 0.76; Asn, His, Cit, Orn, Lys, Ile, 0.76; Asn, His, Tyr, Met, Ile, Phe, 0.76; Asn, Thr, Arg, Orn, Lys, Ile, 0.76; Asn, Cit, Arg, Orn, Lys, Ile, 0.76; Cit, Pro, Orn, Lys, Ile, 0.76; Asn, Cit, Tyr, Val, Lys, Ile, 0.76; Asn, Cit, Val, Lys, Ile, Leu, 0.76; Asn, Arg, Val, Lys, Ile, Phe, 0.76; Gly, Gln, His, Ile, Leu, Phe, 0.76; Gly, Gln, His, Ile, Phe, Trp, 0.76; Gly, Gln, Ala, Cit, Tyr, Ile, 0.76; Cit, Tyr, Met, Ile, 0.76; Gly, Gln, Arg, Tyr, Leu, Phe, 0.76; Gly, Gln, Tyr, Met, Ile, Trp, 0.76; Gln, His, Thr, Ala, Cit, Ile, Gln, His, Ala, Val, Met, Ile, 0.76; Gln, His, Cit, Orn, Lys, Ile, 0.76; Gln, His, Cit, Ile, Leu, Trp, 0.76; Tyr, Lys, Ile, 0.76; Gln, His, Tyr, Lys, Leu, Trp, 0.76; Gln, His, Val, Met, Ile, Phe, 0.76; Gln, His, Val, Lys, Ile, Phe, 0.76; Gln, Thr, Tyr, Ile, Phe, Trp, 0.76; Gln, Cit, Tyr, Orn, Ile, Leu, 0.76; Gln, Arg, Val, Orn, Lys, Ile, Gln, Pro, Tyr, Val, Ile, Phe, 0.76; His, Thr, Arg, Tyr, Ile, Phe, 0.76; His, Arg, Orn, Lys, Ile, Phe, 0.76; Met, Lys, Ile, 0.76; Ser, Asn, His, Tyr, Met, Ile, 0.759; Ser, Asn, Tyr, Met, Lys, Ile, 0.759; Ser, Gln, Arg, Tyr, Ile, Phe, 0.759; Ser, His, Arg, Tyr, Ile, Phe, 0.759; Asn, Gly, Gln, His, Arg, Ile, 0.759; Asn, Gly, Gln, Lys, Ile, Phe, 0.759; Asn, Gly, His, Lys, Ile, Phe, 0.759; Asn, Gly, Thr, Arg, Lys, Ile, 0.759; Asn, Gly, Tyr, Met, Lys, Ile, 0.759; Asn, Gln, His, Arg, Met, Ile, 0.759; Gln, His, Met, Ile, Leu, 0.759; Asn, Gln, His, Lys, Ile, Trp, 0.759; Asn, Gln, His, Lys, Leu, Phe, 0.759; Asn, Gln, Ala, Tyr, Lys, Leu, 0.759; Asn, Gln, Orn, Lys, Leu, Phe, 0.759; Asn, Gln, Lys, Ile, Phe, Trp, 0.759; Asn, His, Cit, Val, Lys, Ile, 0.759; Arg, Pro, Tyr, Ile, 0.759; Asn, His, Arg, Orn, Ile, Phe, 0.759; Asn, Thr, Cit, Pro, Lys, Ile, 0.759; Asn, Ala, Cit, Lys, Ile, Leu, Asn, Arg, Pro, Tyr, Orn, Lys, 0.759; Asn, Tyr, Val, Met, Lys, Ile, 0.759; Gly, Gln, His, Ala, Tyr, Ile, 0.759; Gly, Gln, Ala, Tyr, Ile, Trp, 0.759; Gly, Gln, Cit, Tyr, Orn, Ile, 0.759; Ile, Trp, 0.759; Gly, Gln, Tyr, Val, Met, Ile, 0.759; Gly, Gln, Tyr, Val, Lys, Ile, 0.759; Gly, Gln, Tyr, Val, Lys, Trp, 0.759; Gln, Tyr, Met, Lys, Leu, 0.759; Gly, Gln, Tyr, Ile, Leu, Trp, 0.759; Gln, His, Thr, Ala, Met, Ile, 0.759; Gln, His, Thr, Cit, Ile, Leu, 0.759; Gln, His, Thr, Tyr, Ile, Leu, 0.759; Gln, His, Ala, Cit, Val, Ile, 0.759; Gln, His, Ala, Arg, Ile, Trp, 0.759; Ala, Pro, Met, Ile, 0.759; Gln, His, Ala, Met, Ile, Trp, 0.759; Gln, His, Ala, Ile, Phe, Trp, 0.759; Gln, His, Cit, Arg, Tyr, Ile, Gln, His, Cit, Arg, Ile, Leu, 0.759; Gln, His, Cit, Val, Ile, Trp, 0.759; Gln, His, Arg, Val, Lys, Ile, 0.759; Tyr, Ile, Leu, 0.759; Gln, His, Tyr, Met, Lys, Ile, 0.759; Gln, Thr, Pro, Tyr, Ile, Phe, 0.759; Gln, Thr, Tyr, Lys, Leu, Phe, 0.759; Gln, Ala, Pro, Tyr, Ile, Phe, 0.759; Gln, Arg, Tyr, Ile, Leu, Trp, 0.759; Gln, Arg, Orn, Lys, Ile, Leu, 0.759; Gln, Tyr, Met, Orn, Ile, Phe, 0.759; Gln, Tyr, Met, Lys, Ile, Trp, 0.759; His, Thr, Tyr, Ile, Phe, Trp, 0.759; His, Cit, Tyr, Ile, Phe, Trp, 0.759; His, Pro, Tyr, Met, Ile, Phe, 0.759; His, Tyr, Met, Lys, Ile, Trp, 0.759; Tyr, Orn, Lys, Ile, Trp, 0.759; Arg, Tyr, Lys, Ile, Leu, Trp, 0.759; Ser, Asn, Gly, Arg, Lys, Ile, 0.759; Ser, Asn, Gln, His, Arg, Ile, 0.759; Ser, Asn, His, Cit, Tyr, Ile, 0.759; Ser, Asn, His, Arg, Tyr, Ile, 0.759; Ser, Asn, Cit, Tyr, Orn, Ile, 0.759; Gln, Tyr, Ile, Trp, 0.759; Ser, Gly, Gln, Tyr, Leu, Trp, 0.759; Ser, Gln, His, Cit, Tyr, Ile, 0.759; Ser, Gln, Thr, Tyr, Lys, Ile, 0.759; Ser, Gln, Tyr, Lys, Ile, Leu, 0.759; Ser, His, Thr, Tyr, Ile, Phe, 0.759; Ser, Arg, Lys, Ile, Phe, Trp, 0.759; Asn, Gly, Cit, Arg, Tyr, Ile, 0.759; Asn, Gly, Cit, Arg, Lys, Ile, 0.759; Asn, Gly, Arg, Lys, Ile, Trp, 0.759; Asn, Gly, Tyr, Lys, Leu, Phe, 0.759; Asn, Gln, His, Thr, Pro, Ile, 0.759; sn, Gln, His, Pro, Ile, Trp, 0.759; Asn, Gln, His, Tyr, Val, Leu, 0.759; Asn, Gln, His, Tyr, Lys, Leu, 0.759; Asn, Gln, His, Orn, Lys, Ile, 0.759; Asn, Gln, His, Orn, Ile, Trp, 0.759; Asn, Gln, Ala, Cit, Lys, Ile, 0.759; Asn, Gln, Ala, Tyr, Ile, Phe, 0.759; Gln, Cit, Lys, Leu, Phe, 0.759; Asn, Gln, Val, Lys, Leu, Phe, 0.759; Asn, His, Cit, Lys, Ile, Leu, 0.759; Asn, Thr, Cit, Tyr, Leu, Phe, 0.759; Asn, Thr, Tyr, Lys, Ile, Phe, 0.759; Asn, Arg, Tyr, Met, Lys, Leu, 0.759; Asn, Pro, Tyr, Lys, Leu, Phe, 0.759; Met, Lys, Ile, Trp, 0.759; Gly, Gln, His, Ala, Tyr, Leu, 0.759; Gly, Gln, Thr, Tyr, Lys, Ile, 0.759; Gly, Gln, Ala, Tyr, Lys, Ile, Gly, Gln, Cit, Tyr, Val, Ile, 0.759; Gly, Gln, Arg, Lys, Ile, Leu, 0.759; Gly, Gln, Pro, Tyr, Lys, Ile, 0.759; Tyr, Ile, Leu, 0.759; Gly, Gln, Tyr, Val, Leu, Trp, 0.759; Gly, His, Tyr, Met, Ile, Trp, 0.759; Gln, His, Thr, Tyr, Val, Ile, 0.759; Gln, His, Thr, Tyr, Lys, Ile, 0.759; Gln, His, Ala, Val, Ile, Trp, 0.759; n, His, Ala, Orn, Ile, Phe, 0.759; Gln, His, Cit, Arg, Met, Ile, 0.759; Gln, His, Cit, Val, Met, Ile, 0.759; Ile, Leu, 0.759; Gln, His, Pro, Tyr, Val, Ile, 0.759; Gln, His, Tyr, Val, Orn, Trp, 0.759; Gln, His, Tyr, Met, Lys, Leu, 0.759; His, Val, Orn, Ile, Phe, 0.759; Gln, His, Met, Ile, Leu, Phe, 0.759; Gln, His, Orn, Ile, Leu, Phe, 0.759; Trp, 0.759; Gln, Thr, Tyr, Orn, Ile, Phe, 0.759; Gln, Thr, Tyr, Leu, Phe, Trp, 0.759; Gln, Ala, Arg, Lys, Ile, Phe, 0.759; Tyr, Lys, Leu, Phe, 0.759; Gln, Ala, Tyr, Ile, Leu, Phe, 0.759; Gln, Cit, Tyr, Lys, Ile, Trp, 0.759; Gln, Arg, Tyr, Orn, Lys, Ile, Gln, Arg, Val, Lys, Ile, Leu, 0.759; Gln, Pro, Tyr, Orn, Ile, Phe, 0.759; Gln, Tyr, Val, Met, Lys, Ile, 0.759; Orn, Ile, Phe, 0.759; His, Thr, Ala, Tyr, Ile, Phe, 0.759; His, Ala, Cit, Tyr, Ile, Phe, 0.759; His, Ala, Arg, Tyr, Ile, Phe, 0.759; His, Cit, Arg, Tyr, Met, Ile, 0.759; His, Arg, Tyr, Ile, Phe, Trp, 0.759; , Pro, Tyr, Met, Ile, Trp, 0.759; His, Tyr, Val, Met, Lys, Ile, 0.759; His, Tyr, Met, Lys, Ile, Leu, 0.759; Thr, Tyr, Orn, Lys, Ile , Phe, 0.759; Cit, Tyr, Met, Lys, Ile, Phe, 0.759; Cit, Tyr, Lys, Ile, Leu, Trp, 0.759; Arg, Pro, Tyr, Orn, Lys, Ile, 0.759; , Orn, Lys, Ile, Leu, 0.759; Ser, Asn, Gly, Gln, Lys, Leu, 0.758; Ser, Asn, Gln, His, Cit, Ile, 0.758; Ser, Asn, Gln, His, Tyr, Leu Ser, Asn, Gln, His, Lys, Ile, 0.758; Ser, Asn, Cit, Arg, Lys, Ile, 0.758; Ser, Gln, His, Tyr, Leu, Trp, 0.758; Ser, Gln, Cit , Tyr, Ile, Phe, 0.758; Ser, Gln, Arg, Met, Lys, Ile, 0.758; Ser, Gln, Tyr, Met, Leu, Phe, 0.758; Ser, Gln, Tyr, Ile, Leu, Trp, 0.758 Ser, His, Tyr, Met, Ile, Trp, 0.758; Asn, Gly, Gln, His, Tyr, Val, 0.758; Asn, Gly, Gln, Ala, Lys, Ile, 0.758; Asn, Gly, Gln, Arg , Tyr, Leu, 0.758; Asn, Gly, Gln, Tyr, Val, Lys, 0.758; Asn, Gly, Gln, Tyr, Ile, Phe, 0.758; Asn, Gly, Gln, Val, Lys, Leu, 0.758; , Gly, Cit, Tyr, Ile, Trp, 0.758; Asn, Gln, His, Thr, Arg, Ile, 0.758; Asn, Gln, His, Thr, Lys, Ile, 0.758; Asn, Gln, His, Met, Ile, Trp, 0.758; Asn, Gln, Cit, Arg, Lys, Ile, 0.758; Asn, Gln, Cit, Tyr, Ile, Phe, 0.758; Asn, Gln, Tyr, Met, Lys, Leu, 0.758; Asn, His, Cit, Tyr, Ile, Trp, 0.758; Asn, His, Tyr, Lys, Ile, Phe, 0.758; Tyr, Ile, Phe, Trp, 0.758; Asn, Thr, Cit, Lys, Ile, Leu, 0.758; Asn, Ala, Cit, Tyr, Ile, Phe, 0.758; Asn, Ala, Tyr, Met, Lys, Ile, Asn, Cit, Pro, Tyr, Lys, Ile, 0.758; Asn, Cit, Pro, Met, Lys, Ile, 0.758; Asn, Cit, Pro, Lys, Ile, Phe, 0.758; Asn, Cit, Tyr, Orn, Ile, Phe, 0.758; Asn, Cit, Lys, Ile, Leu, Phe, 0.758; Asn, Cit, Lys, Ile, Leu, Trp, 0.758; Asn, Arg, Tyr, Orn, Lys, Leu, 0.758; Gly, Gln, His, Thr, Tyr, Ile, 0.758; Gly, Gln, His, Ala, Met, Ile, 0.758; Gly, Gln, His, Tyr, Orn, Leu, 0.758; Lys, Ile, 0.758; Gly, Gln, Thr, Tyr, Ile, Trp, 0.758; Gly, Gln, Thr, Tyr, Leu, Trp, 0.758; Gly, Gln, Ala, Tyr, Val, Ile, 0.758; His, Thr, Cit, Arg, Ile, 0.758; Gln, His, Thr, Cit, Ile, Trp, 0.758; Gln, His, Thr, Pro, Tyr, Ile, 0.758; Gln, His, Ala, Cit, Met, Ile, 0.758; Gln, His, Ala, Val, Ile, Phe, 0.758; Gln, His, Ala, Ile, Leu, Phe, 0.758; Gln, His, Cit, Tyr, Met, Ile, 0.758; Gln, His, Arg, Met, Ile, Phe, 0.758; Gln, His, Orn, Lys, Ile, Phe, 0.758; Arg, Val, Lys, Ile, 0.758; Gln, Ala, Tyr, Lys, Ile, Trp, 0.758; Gln, Cit, Tyr, Orn, Leu, Phe, 0.758; Gln, Arg, Tyr, Val, Ile, Phe, 0.758; His, Ala, Arg, Tyr, Lys, Ile, 0.758; His, Ala, Tyr, Ile, Phe, Trp, 0.758; His, Cit, Arg, Tyr, Lys, Ile, 0.758; His, Cit, Tyr, Ile, Leu, Phe, 0.758; His, Arg, Pro, Tyr, Lys, Ile, 0.758; His, Arg, Tyr, Val, Lys, Ile, 0.758; Thr, Arg, Tyr, Ile, Leu, Phe, 0.758; Tyr, Val, Met, Lys, Ile, Phe, 0.758; Tyr, Met, Lys, Ile, Leu, Phe, 0.758; Ser, Asn, Gly, Gln, Tyr, Ile, 0.757; Ser, Gly, Gln, Thr, Tyr, Ile, 0.757; Ser, Gln, His, Orn, Ile, Phe, 0.757; Ser, His, Cit, Tyr, Ile, Phe, 0.757; Gly, Gln, His, Met, Ile, 0.757; Asn, Gly, Gln, Thr, Lys, Ile, 0.757; Asn, G ly, Gln, Cit, Orn, Ile, 0.757; Asn, Gly, Gln, Tyr, Orn, Leu, 0.757; Asn, Gly, Thr, Tyr, Leu, Phe, 0.757; Ile, 0.757; Asn, Gly, Arg, Tyr, Leu, Phe, 0.757; Asn, Gln, His, Cit, Tyr, Leu, 0.757; Asn, Gln, His, Val, Ile, Trp, 0.757; His, Met, Orn, Ile, 0.757; Asn, Gln, Thr, Tyr, Ile, Leu, 0.757; Asn, Gln, Cit, Ile, Leu, Phe, 0.757; Asn, Thr, Arg, Lys, Ile, Trp, Asn, Arg, Tyr, Lys, Leu, Trp, 0.757; Gly, Gln, His, Thr, Cit, Ile, 0.757; Gly, Gln, His, Ala, Ile, Phe, 0.757; Arg, Lys, Ile, 0.757; Gly, Gln, Cit, Pro, Tyr, Ile, 0.757; Gly, Gln, Arg, Tyr, Ile, Leu, 0.757; 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Gln, Thr, Arg, Orn, Lys, Ile, 0.757; Gln, Thr, Tyr, Met, Lys, Ile, 0.757; Pro, Tyr, Leu, Phe, 0.757; Gln, Arg, Val, Met, Lys, Ile, 0.757; Gln, Arg, Val, Lys, Ile, Trp, 0.757; Gln, Tyr, Val, Lys, Ile, Trp, 0.757; Ala, Arg, Tyr, Lys, Ile, Trp, 0.757; Arg, Tyr, Lys, Leu, Phe, Trp, 0.757; Tyr, Met, Orn, Lys, Ile, Phe, 0.757; Ser, Asn, Gln, His, Ala, Ile, 0.757; Ser, Asn, His, Arg, Lys, Ile, 0.757; Ser, Asn, Ala, Arg, Lys, Ile, 0.757; Ser, Asn, Tyr, Met, Leu, Phe, 0.757; Ser, Gln, His, Tyr, Lys, Ile, 0.757; Ser, Gln, His, Ile, Phe, Trp, 0.757; Ser, Gln, Thr, Tyr, Leu, Phe, 0.757; Ser, His, Tyr, Met, Ile, Phe, 0.757; Ser, Arg, Tyr, Ile, Leu, Phe, 0.757; Asn, Gly, Gln, Thr, Tyr, Ile, 0.757; Gly, Gln, Thr, Tyr, Leu, 0.757; Asn, Gly, Gln, Ala, Tyr, Leu, 0.757; Asn, Gly, Gln, Arg, Tyr, Ile, 0.757; Ile, 0.757; Asn, Gly, Gln, Tyr, Orn, Ile, 0.757; Asn, Gly, Gln, Lys, Leu, Trp Asn, Gln, His, Arg, Tyr, Val, 0.757; Asn, Gln, His, Tyr, Met, Leu, 0.757; Asn, Gln, His, Met, Lys, Ile, 0.757; Asn, Gln, Thr , Tyr, Lys, Ile, 0.757; Asn, Gln, Cit, Tyr, Orn, Ile, 0.757; Asn, Gln, Cit, Tyr, Ile, Leu, 0.757; Asn, Gln, Val, Ile, Leu, Phe, 0.757 Asn, His, Thr, Tyr, Ile, Phe, 0.757; Asn, His, Tyr, Met, Ile, Trp, 0.757; Asn, His, Tyr, Orn, Ile, Phe, 0.757; Asn, His, Orn, Lys , Ile, Phe, 0.757; Asn, Thr, Cit, Orn, Lys, Ile, 0.757; Asn, Ala, Cit, Pro, Lys, Ile, 0.757; Asn, Cit, Arg, Val, Lys, Ile, 0.757; , Cit, Arg, Lys, Ile, Trp, 0.757; Asn, Cit, Tyr, Met, Ile, Phe, 0.757; Asn, Cit, Tyr, Lys, Leu, Phe, 0.757; , Leu, 0.757; Asn, Pro, Tyr, Met, Lys, Ile, 0.757; Asn, Tyr, Met, Ile, Leu, Phe, 0.757; Asn, Tyr, Orn, Ile, Leu, Phe, 0.757; , Lys, Ile, Leu, Phe, 0.757; Gly, Gln, His, Tyr, Val, Phe, 0.757; Gly, Gln, His, Val, Ile, Phe, 0.757; , 0.757; Gly, Gln, Thr, Arg, Lys, Ile, 0.757; Gly, Gln, Cit, Tyr, Leu, Trp, Gly, Gln, Arg, Tyr, Val, Ile, 0.757; Gly, Gln, Lys, Ile, Leu, Phe, 0.757; Gly, Cit, Tyr, Lys, Ile, Trp, 0.757; Ile, Leu, Phe, 0.757; Gln, His, Thr, Ala, Ile, Phe, 0.757; Gln, His, Thr, Cit, Met, Ile, 0.757; Gln, His, Thr, Tyr, Leu, Phe, 0.757; 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Gln, Orn, Lys, Ile, Leu, Phe, 0.756; Ala, Cit, Tyr, Met, Ile, 0.756; His, Tyr, Val, Met, Ile, Phe, 0.756; His, Tyr, Met, Ile, Leu, Phe, 0.756; Thr, Arg, Tyr, Orn, Lys, Ile, 0.756; Thr, Tyr, Met, Lys, Ile, Phe, 0.756; Ala, Cit, Arg, Tyr, Lys, Ile, 0.756; Ala, Arg, Tyr, Orn, Lys, Ile, 0.756; Pro, Tyr, Orn, Lys, 0.756; Cit, Arg, Tyr, Lys, Ile, Leu, 0.756; Cit, Tyr, Lys, Ile, Phe, Trp, 0.756; Arg, Tyr, Val, Ile, Leu, Phe, Ser, Asn, Gln, His, Met, Ile, 0.756; Ser, Asn, Gln, His, Ile, Trp, 0.7 Ser, Asn, Gln, Tyr, Val, Ile, 0.756; Ser, Asn, Gln, Lys, Ile, Trp, 0.756; Ser, Asn, His, Cit, Lys, Ile, 0.756; Ser, Asn, Thr, Tyr, Leu, Phe, 0.756; Ser, Gly, Gln, Cit, Tyr, Ile, 0.756; Ser, Gln, His, Arg, Orn, Ile, 0.756; Ser, Gln, His, Arg, Ile, Trp, 0.756; Ser, Gln, His, Tyr, Leu, Phe, 0.756; Ser, Gln, His, Val, Ile, Phe, 0.756; Ser, Gln, His, Met, Lys, Ile, 0.756; Ser, Gln, Cit, Tyr, Leu, Phe, 0.756; Ser, Gln, Tyr, Val, Lys, Ile, 0.756; Ser, His, Ala, Tyr, Ile, Phe, 0.756; Asn, Gly, Gln, His, Lys, Leu, 0.756; Gly, Gln, Orn, Leu, Phe, 0.756; Asn, Gly, Cit, Lys, Ile, Trp, 0.756; Asn, Gly, Arg, Tyr, Ile, Leu, 0.756; Leu, 0.756; Asn, Gln, His, Orn, Leu, Phe, 0.756; Asn, Gln, Thr, Val, Leu, Phe, 0.756; Asn, Gln, Ala, Tyr, Ile, Leu, 0.756; Cit, Tyr, Orn, Leu, 0.756; Asn, Gln, Cit, Tyr, Lys, Leu, 0.756; Asn, Gln, Cit, Lys, Ile, Trp, 0.756; Asn, Gln, Arg, Met, Lys, Ile, Asn, Gln, Arg, Ile, Leu, Phe, 0.756; Asn, Gln, Tyr, Val, Lys, Leu, 0.75 6; Asn, Gln, Lys, Ile, Leu, Trp, 0.756; Asn, Gln, Ile, Leu, Phe, Trp, 0.756; Asn, His, Thr, Tyr, Met, Ile, 0.756; Tyr, Ile, Phe, 0.756; Asn, His, Arg, Tyr, Ile, Leu, 0.756; Asn, His, Pro, Tyr, Met, Ile, 0.756; Asn, His, Val, Lys, Ile, Phe, 0.756; Asn, Thr, Arg, Val, Lys, Ile, 0.756; Asn, Thr, Pro, Tyr, Leu, Phe, 0.756; Asn, Thr, Tyr, Leu, Phe, Trp, 0.756; Asn, Thr, Lys, Ile, Leu, Phe, 0.756; Asn, Ala, Cit, Tyr, Orn, Ile, 0.756; Asn, Ala, Cit, Orn, Lys, Ile, 0.756; Asn, Ala, Arg, Orn, Lys, Ile, 0.756; Cit, Arg, Met, Lys, Ile, 0.756; Asn, Cit, Pro, Tyr, Ile, Phe, 0.756; Asn, Cit, Tyr, Orn, Ile, Trp, 0.756; Asn, Cit, Orn, Lys, Ile, Phe, 0.756; Asn, Tyr, Met, Lys, Ile, Phe, 0.756; Asn, Tyr, Orn, Lys, Leu, Phe, 0.756; Asn, Orn, Lys, Ile, Leu, Phe, 0.756; His, Ala, Ile, Trp, 0.756; Gly, Gln, His, Cit, Met, Ile, 0.756; Gly, Gln, His, Cit, Ile, Leu, 0.756; Gly, Gln, Thr, Ala, Tyr, Ile, Gly, Gln, Thr, Tyr, Ile, Leu, 0.756; Gly, Gln, Lys, Ile, Phe, Trp, 0.756 Gly, His, Cit, Tyr, Met, Ile, 0.756; Gly, Arg, Tyr, Lys, Ile, Trp, 0.756; Gln, His, Thr, Ile, Phe, Trp, 0.756; Gln, His, Cit, Tyr , Lys, Ile, 0.756; Gln, His, Pro, Orn, Ile, Phe, 0.756; Gln, His, Tyr, Lys, Ile, Trp, 0.756; Gln, His, Met, Lys, Ile, Phe, 0.756; , His, Met, Ile, Phe, Trp, 0.756; Gln, His, Orn, Lys, Leu, Phe, 0.756; Gln, Thr, Cit, Arg, Lys, Ile, 0.756; Gln, Thr, Tyr, Ile, Leu , Trp, 0.756; Gln, Ala, Arg, Lys, Ile, Trp, 0.756; Gln, Ala, Tyr, Met, Lys, Ile, 0.756; Gln, Ala, Tyr, Ile, Leu, Trp, 0.756; , Arg, Tyr, Orn, Ile, 0.756; Gln, Cit, Tyr, Lys, Leu, Trp, 0.756; Gln, Arg, Met, Lys, Ile, Phe, 0.756; 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Ser, Gln, Cit, Tyr, Ile, Leu, 0.754; Ser, Gln, Tyr, Orn, Lys, Ile, 0.754; Ser, Thr, Tyr, Lys, Ile, Phe, 0.754; Asn, Gly, Gln, Ala, Tyr, Val, 0.754; Asn, Gly, His, Tyr, Val, Ile, 0.754; Asn, Gly, Ala, Cit, Lys, Ile, 0.754; Asn, Gly, Tyr, Met, Leu, Phe, 0.754; Asn, Gln, His, Thr, Ile, Trp, 0.754; Asn, Gln, His, Ala, Orn, Leu, 0.754; Asn, Gln, His, Tyr, Val, Lys, 0.754; Asn, Gln, His, Orn, Leu, Trp, 0.754; Gln, Ala, Lys, Ile, Leu, 0.754; Asn, Gln, Arg, Tyr, Ile, Phe, 0.754; Asn, Gln, Tyr, Val, Lys, Ile, 0.754; Asn, Gln, Val, Orn, Lys, Ile, 0.754; Asn, Gln, Val, Orn, Lys, Leu, 0.754; Asn, His, Arg, Pro, Ile, Phe, 0.754; Asn, His, Arg, Ile, Leu, Phe, 0.754; Asn, His, Pro, Tyr, Val, Ile, 0.754; Asn, His, Pro, Tyr, Ile, Phe, 0.754; Tyr, Orn, Lys, Ile, 0.754; Asn, His, Tyr, Lys, Ile, Trp, 0.754; Asn, His, Tyr, Lys, Leu, Phe, 0.754; Asn, Thr, Cit, Val, Lys, Ile, Gly, Gln, His, Ala, Lys, Ile, 0.754; Gly, Gln, His, Cit, Val, Ile, 0.754; Gly, Gln, His, Tyr, Val, Ile, 0.754; Lys, Ile, Trp, 0.754; Gly, Gln, Thr, Arg, Tyr, Leu, 0.754; Gly, Gln, Thr, Tyr, Met, Ile, 0.754; Gly, Gln, Thr, Tyr, Lys, Leu, 0.754; Gly, Gln, Thr, Lys, Leu, Phe, 0.754; Gly, Gln, Ala, Pro, Tyr, Ile, 0.754; Gly, Gln, Cit, Orn, Ile, Phe, 0.754; Met, Ile, 0.754; Gly, Gln, Arg, Tyr, Leu, Trp, 0.754; Gly, Gln, Val, Lys, Ile, Phe, 0.754; Gly, His, Ala, Tyr, Ile, Phe, 0.754; His, Tyr, Ile, Leu, Phe, 0.754; Gly, Cit, Tyr, Met, Ile, Phe, 0.754; Gly, Tyr, Met, Ile, Leu, Phe, 0.754; Gln, His, Thr, Pro, Met, Ile, 0.754; Gln, His, Thr, Met, Ile, Phe, 0.754; Gln, His, Ala, Arg, Pro, I le, 0.754; Gln, His, Cit, Tyr, Orn, Leu, 0.754; Gln, His, Cit, Tyr, Lys, Leu, 0.754; Gln, His, Arg, Pro, Met, Ile, 0.754; Arg, Orn, Ile, Leu, 0.754; Gln, His, Arg, Orn, Ile, Trp, 0.754; Gln, His, Arg, Lys, Ile, Trp, 0.754; Gln, His, Pro, Val, Met, Ile, Gln, His, Tyr, Val, Lys, Phe, 0.754; Gln, His, Val, Met, Ile, Trp, 0.754; Gln, Thr, Cit, Tyr, Leu, Phe, 0.754; Tyr, Ile, Leu, 0.754; Gln, Ala, Cit, Tyr, Orn, Ile, 0.754; Gln, Ala, Tyr, Met, Ile, Leu, 0.754; Gln, Cit, Arg, Tyr, Lys, Ile, 0.754; Gln, Cit, Tyr, Met, Leu, Phe, 0.754; Gln, Cit, Val, Ile, Leu, Phe, 0.754; Gln, Arg, Tyr, Met, Ile, Leu, 0.754; Lys, Leu, 0.754; Gln, Arg, Tyr, Orn, Leu, Trp, 0.754; Gln, Arg, Tyr, Lys, Ile, Leu, 0.754; Gln, Arg, Met, Lys, Ile, Leu, 0.754; Arg, Ile, Leu, Phe, Trp, 0.754; Gln, Tyr, Val, Lys, Leu, Trp, 0.754; Gln, Tyr, Met, Orn, Lys, Ile, 0.754; Leu, 0.754; His, Thr, Tyr, Met, Orn, Ile, 0.754; His, Thr, Tyr, Orn, Ile, Ph e, 0.754; His, Arg, Tyr, Met, Ile, Trp, 0.754; His, Arg, Tyr, Lys, Ile, Trp, 0.754; Thr, Tyr, Lys, Ile, Leu, Phe, 0.754; Val, Orn, Lys, Trp, 0.754; Arg, Tyr, Met, Lys, Leu, Phe, 0.754; Arg, Val, Met, Lys, Ile, Phe, 0.754; Arg, Met, Lys, Ile, Phe, Trp, 0.754; Arg, Orn, Lys, Ile, Phe, Trp, 0.754; Tyr, Orn, Lys, Ile, Leu, Phe, 0.754; Ser, Asn, Gly, Gln, Lys, Ile, 0.753; Ser, Asn, Gln, His, Lys, Leu, 0.753; Ser, Asn, Thr, Tyr, Lys, Ile, 0.753; Ser, Asn, Arg, Tyr, Lys, Leu, 0.753; Ser, Asn, Tyr, Ile, Leu, Phe, 0.753; Ser, Gly, Gln, Tyr, Orn, Ile, 0.753; Ser, Gly, Gln, Val, Lys, Ile, 0.753; Ser, Gly, Gln, Lys, Ile, Phe, 0.753; Ser, Gln, His, Thr, Arg, Ile, 0.753; Ser, Gln, His, Ile, Leu, Phe, 0.753; Ser, Gln, Ala, Lys, Leu, Phe, 0.753; Gln, Pro, Tyr, Leu, Trp, 0.753; Ser, Gln, Tyr, Met, Ile, Trp, 0.753; Ser, Gln, Val, Lys, Ile, Trp, 0.753; Ser, His, Cit, Tyr, Met, Ile, 0.753; Ser, His, Arg, Lys, Ile, Phe, 0.753; Ser, Cit, Tyr, Lys, Ile, Trp Asn, Gly, Gln, Tyr, Met, Leu, 0.753; Asn, Gly, His, Arg, Lys, Ile, 0.753; Asn, Gly, His, Tyr, Ile, Leu, 0.753; Asn, Gly, Ala , Arg, Lys, Ile, 0.753; Asn, Gly, Cit, Tyr, Val, Leu, 0.753; Asn, Gly, Cit, Tyr, Leu, Trp, 0.753;

Arg, Pro, Lys, Ile, 0.753; Asn, Gly, Pro, Tyr, Lys, Leu, 0.753; Asn, Gln, His, Ala, Tyr, Val, 0.753; Asn, Gln, His, Pro, Tyr, Lys, Asn, Gln, His, Val, Orn, Leu, 0.753; Asn, Gln, His, Met, Orn, Leu, 0.753; Asn, Gln, Thr, Tyr, Leu, Trp, 0.753; Asn, Gln, Thr, Val, Lys, Ile, 0.753; Asn, Gln, Thr, Orn, Lys, Ile, 0.753; Asn, Gln, Ala, Tyr, Leu, Phe, 0.753; Asn, Gln, Ala, Tyr, Leu, Trp, 0.753; Asn, Gln, Ala, Val, Lys, Ile, 0.753; Asn, Gln, Ala, Orn, Lys, Ile, 0.753; Asn, Gln, Cit, Tyr, Leu, Trp, 0.753; Lys, Leu, 0.753; Asn, Gln, Tyr, Orn, Lys, Ile, 0.753; Asn, Gln, Met, Lys, Ile, Phe, 0.753; Asn, Gln, Met, Lys, Ile, Trp, 0.753; Gln, Orn, Lys, Ile, Trp, 0.753; Asn, Gln, Lys, Leu, Phe, Trp, 0.753; Asn, His, Cit, Arg, Lys, Ile, 0.753; Asn, His, Arg, Ile, Phe, Trp, 0.753; Asn, His, Pro, Tyr, Ile, Trp, 0.753; Asn, His, Pro, Met, Lys, Ile, 0.753; Asn, His, Tyr, Val, Ile, Leu, 0.753; Pro, Lys, Ile, Leu, 0.753; Asn, Cit, Tyr, Lys, Leu, Trp, 0.753; Asn, Cit, T yr, Ile, Leu, Trp, 0.753; Asn, Arg, Val, Lys, Ile, Trp, 0.753; Asn, Arg, Met, Lys, Ile, Trp, 0.753; Asn, Tyr, Val, Met, Leu, Phe, Asn, Tyr, Met, Orn, Lys, Ile, 0.753; Asn, Tyr, Ile, Leu, Phe, Trp, 0.753; Asn, Val, Lys, Ile, Leu, Phe, 0.753; Gly, Gln, His, Thr, Ile, Phe, 0.753; Gly, Gln, His, Ala, Cit, Ile, 0.753; Gly, Gln, His, Arg, Tyr, Val, 0.753; Gly, Gln, His, Tyr, Val, Lys, 0.753; Gly, Gln, His, Met, Orn, Ile, 0.753; Gly, Gln, His, Orn, Lys, Ile, 0.753; Gly, Gln, His, Lys, Ile, Leu, 0.753; Val, Ile, 0.753; Gly, Gln, Ala, Cit, Lys, Ile, 0.753; Gly, Gln, Cit, Lys, Ile, Trp, 0.753; Gly, Gln, Pro, Tyr, Lys, Leu, 0.753; Gln, Tyr, Val, Lys, Phe, 0.753; Gly, Gln, Orn, Lys, Ile, Trp, 0.753; Gly, Ala, Arg, Lys, Ile, Phe, 0.753; Trp, 0.753; Gly, Cit, Tyr, Met, Orn, Ile, 0.753; Gly, Arg, Orn, Lys, Ile, Phe, 0.753; Gln, His, Thr, Arg, Orn, Ile, 0.753; Thr, Val, Ile, Phe, 0.753; Gln, His, Ala, Arg, Ile, Leu, 0.753; Gln, His, Al a, Pro, Val, Ile, 0.753; Gln, His, Arg, Pro, Ile, Leu, 0.753; Gln, His, Arg, Met, Ile, Trp, 0.753; Gln, His, Pro, Tyr, Lys, Leu, 0.753; Gln, His, Pro, Met, Ile, Leu, 0.753; Gln, His, Tyr, Val, Orn, Leu, 0.753; Ile, Leu, Trp, 0.753; Gln, Thr, Cit, Tyr, Orn, Ile, 0.753; Gln, Thr, Lys, Ile, Leu, Trp, 0.753; Gln, Ala, Arg, Tyr, Lys, Ile, 0.753; Gln, Ala, Arg, Met, Lys, Ile, 0.753; Gln, Cit, Pro, Orn, Ile, Trp, 0.753; Gln, Cit, Tyr, Val, Orn, Ile, 0.753; Ile, Trp, 0.753; Gln, Cit, Lys, Ile, Leu, Phe, 0.753; Gln, Arg, Tyr, Met, Leu, Phe, 0.753; Gln, Arg, Tyr, Leu, Phe, Trp, 0.753; Pro, Tyr, Lys, Ile, Trp, 0.753; Gln, Pro, Tyr, Lys, Leu, Trp, 0.753; Gln, Val, Orn, Lys, Ile, Phe, 0.753; His, Thr, Tyr, Met, Lys, Ile, 0.753; His, Thr, Tyr, Ile, Leu, Phe, 0.753; Thr, Tyr, Orn, Ile, Leu, Phe, 0.753; Ala, Arg, Lys, Ile, Leu, Phe, 0.753; Pro, Tyr, Lys, Ile, 0.753; Arg, Val, Orn, Lys, Ile, Phe, 0.753; Ser, Asn, Gln , Arg, Tyr, Ile, 0.752; Ser, Asn, Gln, Met, Lys, Ile, 0.752; Ser, Asn, His, Tyr, Ile, Trp, 0.752; Ser, Asn, Cit, Pro, Tyr, Ile, 0.752 Ser, Asn, Cit, Tyr, Leu, Phe, 0.752; Ser, Gly, Gln, Arg, Tyr, Ile, 0.752; Ser, Gly, Gln, Tyr, Lys, Leu, 0.752; Ser, Gln, His, Tyr Ser, Gln, His, Tyr, Met, Leu, 0.752; Ser, Gln, Thr, Lys, Ile, Trp, 0.752; Ser, Gln, Cit, Lys, Ile, Phe, 0.752; , Gln, Tyr, Lys, Leu, Phe, 0.752; Ser, Gln, Val, Lys, Ile, Phe, 0.752; Ser, His, Tyr, Ile, Phe, Trp, 0.752; Ser, Thr, Arg, Lys, Ile Ser, Ala, Arg, Lys, Ile, Phe, 0.752; Asn, Gly, Gln, Arg, Orn, Leu, 0.752; Asn, Gly, Gln, Pro, Lys, Ile, 0.752; , His, Tyr, Lys, Leu, 0.752; Asn, Gly, His, Met, Ile, Phe, 0.752; Asn, Gly, Ala, Tyr, Lys, Leu, 0.752; Asn, Gln, His, Ala, Orn, Lys, 0.752; Asn, Gln, His, Ala, Lys, Leu, 0.752; Asn, Gln, His, Pro, Lys, Ile, 0.752; Asn, Gln, His , Tyr, Lys, Phe, 0.752; Asn, Gln, Thr, Cit, Tyr, Leu, 0.752; Asn, Gln, Thr, Tyr, Lys, Leu, 0.752; Asn, Gln, Cit, Tyr, Met, Leu, 0.752; Asn, Gln, Arg, Tyr, Leu, Trp, 0.752; Asn, Gln, Arg, Lys, Leu, Phe, 0.752; Asn, Gln, Tyr, Val, Leu, Trp, 0.752; Asn, Gln, Tyr, Met, Orn, Leu, 0.752; Asn, Gln, Met, Lys, Ile, Leu, 0.752; Ile, Leu, 0.752; Asn, His, Thr, Arg, Ile, Phe, 0.752; Asn, His, Thr, Met, Ile, Phe, 0.752; Asn, His, Thr, Orn, Ile, Phe, 0.752; His, Ala, Pro, Tyr, Ile, 0.752; Asn, His, Cit, Val, Orn, Lys, 0.752; Asn, His, Arg, Pro, Tyr, Lys, 0.752; Asn, His, Pro, Lys, Ile, Phe, 0.752; Asn, His, Tyr, Val, Ile, Trp, 0.752; Asn, His, Met, Orn, Lys, Ile, 0.752; Asn, Thr, Cit, Tyr, Val, Ile, 0.752; Cit, Tyr, Ile, Phe, 0.752; Asn, Thr, Tyr, Met, Lys, Leu, 0.752; Asn, Ala, Cit, Val, Lys, Ile, 0.752; Asn, Cit, Arg, Pro, Lys, Ile, Asn, Cit, Arg, Tyr, Ile, Phe, 0.752; Asn, Cit, Tyr, Met, Orn, Ile, 0.752; Asn, Cit, Tyr, Met, Leu, Phe, 0.752; Asn, Cit, Tyr, Orn, Lys, Leu, 0.752; Asn, Arg, Tyr, Orn, Leu, Phe, 0.752; Asn, Arg, Tyr, Ile, Leu, Phe, 0.752; Asn, Arg, Val, Met, Lys, Ile, 0.752; Asn, Pro, Tyr, Ile, Leu, Phe, 0.752; Asn, Tyr, Val, Ile, Leu, Phe, 0.752; Gly, Gln, His, Thr, Tyr, Leu, 0.752; Gly, Gln, His, Pro, Ile, Phe, 0.752; Gly, Gln, His, Lys, Leu, Phe, 0.752; Tyr, Leu, 0.752; Gly, Gln, Thr, Tyr, Val, Leu, 0.752; Gly, Gln, Thr, Lys, Ile, Trp, 0.752; Gly, Gln, Ala, Cit, Orn, Ile, 0.752; Gln, Cit, Val, Orn, Ile, 0.752; Gly, Gln, Arg, Tyr, Ile, Trp, 0.752; Gly, Gln, Tyr, Met, Orn, Ile, 0.752; Phe, 0.752; Gly, His, Thr, Tyr, Met, Ile, 0.752; Gly, His, Tyr, Met, Orn, Ile, 0.752; Gly, His, Tyr, Lys, Ile, Phe, 0.752; Tyr, Ile, Phe, Trp, 0.752; Gly, Ala, Cit, Tyr, Val, Ile, 0.752; Gly, Arg, Lys, Ile, Leu, Phe, 0.752; Gln, His, Thr, Ala, Arg, Ile, Gln, His, Thr, Arg, Met, Ile, 0.752; Gln, His, Thr, Arg, Ile, Trp, 0.752; Gln, His, Thr, Pro, Ile, Leu, 0.752; Pro, Ile, Phe, 0.752; Gln, His, Thr, Met, Ile, Leu, 0.752; Gln, His, Arg, T yr, Orn, Lys, 0.752; Gln, His, Arg, Val, Ile, Leu, 0.752; Gln, His, Arg, Met, Orn, Ile, 0.752; Gln, His, Pro, Met, Ile, Trp, 0.752; Gln, His, Tyr, Val, Met, Leu, 0.752; Gln, His, Met, Orn, Leu, Phe, 0.752; Gln, Thr, Arg, Tyr, Leu, Phe, 0.752; Ile, Leu, 0.752; Gln, Ala, Arg, Val, Lys, Ile, 0.752; Gln, Ala, Arg, Lys, Ile, Leu, 0.752; Gln, Cit, Arg, Met, Lys, Ile, 0.752; Cit, Tyr, Val, Ile, Phe, 0.752; Gln, Cit, Tyr, Met, Lys, Ile, 0.752; Gln, Arg, Tyr, Met, Ile, Phe, 0.752; Trp, 0.752; Gln, Tyr, Val, Orn, Leu, Trp, 0.752; Gln, Tyr, Met, Orn, Leu, Trp, 0.752; Gln, Val, Lys, Ile, Phe, Trp, 0.752; Tyr, Met, Ile, Trp, 0.752; His, Tyr, Lys, Ile, Phe, Trp, 0.752; Thr, Arg, Orn, Lys, Ile, Phe, 0.752; Thr, Pro, Tyr, Ile, Leu, Phe, Cit, Arg, Tyr, Orn, Leu, Trp, 0.752; Cit, Tyr, Met, Ile, Leu, Phe, 0.752; Ser, Asn, Gln, Thr, Lys, Leu, 0.752; Ser, Asn, Gln, Arg, Lys, Leu, 0.752; Ser, Asn, Gln, Pro, Lys, Ile, 0.752; Ser, Asn, His, Ar g, Ile, Phe, 0.752; Ser, Asn, His, Tyr, Orn, Ile, 0.752; Ser, Asn, Ala, Cit, Tyr, Ile, 0.752; Ser, Asn, Cit, Arg, Tyr, Ile, 0.752; Ser, Gly, Gln, His, Arg, Ile, 0.752; Ser, Gly, Gln, His, Tyr, Val, 0.752; Ser, Gly, Gln, Lys, Ile, Trp, 0.752; Ser, Gln, His, Thr, Cit, Ile, 0.752; Ser, Gln, His, Ala, Arg, Ile, 0.752; Ser, Gln, His, Ala, Ile, Phe, 0.752; Ser, Gln, His, Pro, Ile, Phe, 0.752; Gln, His, Met, Ile, Phe, 0.752; Ser, Gln, His, Lys, Ile, Phe, 0.752; Ser, Gln, Tyr, Val, Leu, Phe, 0.752; Ser, Gln, Tyr, Met, Ile, Leu, 0.752; Ser, Gln, Tyr, Lys, Leu, Trp, 0.752; Ser, Gln, Val, Met, Lys, Ile, 0.752; Ser, Gln, Lys, Ile, Leu, Phe, 0.752; Lys, Ile, Leu, Trp, 0.752; Ser, His, Ala, Tyr, Met, Ile, 0.752; Ser, His, Tyr, Orn, Ile, Phe, 0.752; Ser, Thr, Tyr, Ile, Leu, Phe, Ser, Cit, Tyr, Ile, Leu, Phe, 0.752; Ser, Arg, Tyr, Lys, Leu, Phe, 0.752; Asn, Gly, Gln, Orn, Leu, Trp, 0.752; Asn, Gly, His, Ala, Tyr, Ile, 0.752; Asn, Gly, His, Tyr, Lys, Ile, 0.752; Asn, Gly, Thr, Tyr , Ile, Leu, 0.752; Asn, Gly, Cit, Arg, Tyr, Leu, 0.752; Asn, Gly, Tyr, Orn, Ile, Leu, 0.752; Asn, Gln, His, Arg, Tyr, Leu, 0.752; , Gln, Thr, Lys, Leu, Trp, 0.752; Asn, Gln, Cit, Tyr, Met, Ile, 0.752; Asn, Gln, Cit, Val, Lys, Leu, 0.752; Asn, Gln, Pro, Lys, Leu , Phe, 0.752; Asn, Gln, Tyr, Met, Leu, Trp, 0.752; Asn, Gln, Val, Met, Lys, Ile, 0.752; Asn, Gln, Orn, Lys, Leu, Trp, 0.752; , Cit, Arg, Orn, Ile, 0.752; Asn, His, Cit, Tyr, Leu, Phe, 0.752; Asn, His, Cit, Orn, Ile, Phe, 0.752; Asn, His, Arg, Met, Lys, Ile, 0.752; Asn, His, Arg, Lys, Ile, Leu, 0.752; Asn, His, Tyr, Val, Ile, Phe, 0.752; Asn, His, Tyr , Ile, Leu, Phe, 0.752; Asn, Thr, Ala, Cit, Lys, Ile, 0.752; Asn, Thr, Orn, Lys, Ile, Leu, 0.752; Asn, Ala, Cit, Tyr, Met, Ile, 0.752 Asn, Ala, Arg, Tyr, Lys, Leu, 0.752; Asn, Ala, Arg, Val, Lys, Ile, 0.752; Asn, Cit, Arg, Tyr, Orn, Ile, 0.752; Asn, Cit, Arg, Tyr , Lys, Leu, 0.752; Asn, Cit, Tyr, Val, Orn, Ile, 0.752; Asn, Cit, Tyr, Met, Lys, Leu, 0.752; Asn, Cit, Tyr, Orn, Ile, Leu, 0.752; Asn, Cit, Val, Lys, Ile, Phe, 0.752; Asn, Cit, Met, Lys, Ile, Phe, 0.752; Arg, Pro, Tyr, Lys, Leu, 0.752; Asn, Arg, Pro, Tyr, Lys, Phe, 0.752; Asn, Arg, Pro, Orn, Lys, Ile, 0.752; Asn, Arg, Tyr, Val, Lys, Trp, 0.752; Asn, Arg, Tyr, Val, Leu, Phe, 0.752; Asn, Tyr, Met, Orn, Leu, Phe, 0.752; Asn, Tyr, Met, Lys, Leu, Trp, 0.752; His, Thr, Met, Ile, 0.752; Gly, Gln, His, Val, Met, Ile, 0.752; Gly, Gln, Thr, Tyr, Val, Phe, 0.752; Gly, Gln, Thr, Tyr, Orn, Ile, Gly, Gln, Ala, Cit, Arg, Ile, 0.752; Gly, Gln, Ala, Cit, Ile, Trp, 0.752; Gly, Gln, Cit, Tyr, Val, Leu, 0.752; Tyr, Orn, Ile, 0.752; Gly, Gln, Pro, Tyr, Met, Leu, 0.752; Gly, Gln, Tyr, Val, Ile, Trp, 0.752; Gly, Gln, Tyr, Orn, Ile, Phe, 0.752; Gly, His, Pro, Tyr, Ile, Phe, 0.752; Gly, Thr, Tyr, Ile, Leu, Phe, 0.752; Gly, Cit, Arg, Tyr, Ile, Phe, 0.752; Val, Ile, 0.752; Gly, Cit, Tyr, Met, Lys, Ile, 0.752; Gly, Cit, Tyr, Orn, Ile, Phe, 0.752; Gly, Cit, Tyr, Ile, Phe, Trp, 0.752; Gly, Arg, Tyr, Lys, Leu, Phe, 0.752; Gly, Arg, Val, Lys, Ile, Phe, 0.752; His, Ala, Tyr, Orn, Leu, 0.752; Gln, His, Ala, Tyr, Leu, Phe, 0.752; Gln, His, Cit, Tyr, Leu, Trp, 0.752;

n, His, Arg, Pro, Ile, Trp, 0.752; Gln, His, Arg, Val, Ile, Trp, 0.752; Gln, His, Arg, Orn, Leu, Phe, 0.752; Orn, Leu, 0.752; Gln, His, Orn, Leu, Phe, Trp, 0.752; Gln, His, Lys, Ile, Leu, Trp, 0.752; Gln, Thr, Cit, Val, Ile, Leu, 0.752; Thr, Tyr, Val, Ile, Leu, 0.752; Gln, Thr, Tyr, Orn, Ile, Leu, 0.752; Gln, Thr, Orn, Lys, Ile, Phe, 0.752; Trp, 0.752; Gln, Thr, Lys, Ile, Phe, Trp, 0.752; Gln, Ala, Cit, Arg, Lys, Ile, 0.752; Gln, Ala, Tyr, Val, Lys, Trp, 0.752; Val, Lys, Ile, Trp, 0.752; Gln, Cit, Pro, Tyr, Lys, Ile, 0.752; Gln, Cit, Tyr, Val, Lys, Ile, 0.752; Gln, Cit, Tyr, Met, Ile, Leu, 0.752; Gln, Cit, Val, Lys, Ile, Phe, 0.752; Gln, Arg, Tyr, Val, Lys, Trp, 0.752; Val, Leu, Phe, 0.752; Gln, Tyr, Val, Met, Ile, Trp, 0.752; Gln, Tyr, Val, Orn, Lys, Trp, 0.752; Gln, Tyr, Val, Lys, Ile, Leu, 0.752; Gln, Tyr, Met, Orn, Lys, Leu, 0.752; Gln, Orn, Ile, Leu, Phe, Trp, 0.752; , Thr, Cit, Tyr, Met, Ile, 0.752; His, Thr, Tyr, Val, Ile, Phe, 0.752; His, Ala, Tyr, Orn, Ile, Phe, 0.752; His, Cit, Pro, Tyr, Met His, Arg, Lys, Ile, Phe, Trp, 0.752; His, Tyr, Val, Ile, Phe, Trp, 0.752; His, Tyr, Orn, Ile, Phe, Trp, 0.752; , Ile, Leu, Phe, Trp, 0.752; Thr, Ala, Arg, Lys, Ile, Phe, 0.752; Thr, Arg, Met, Lys, Ile, Phe, 0.752; Thr, Pro, Tyr, Met, Leu, Phe Thr, Pro, Tyr, Lys, Ile, Phe, 0.752; Thr, Tyr, Val, Ile, Leu, Phe, 0.752; Ala, Arg, Tyr, Lys, Ile, Leu, 0.752; Ala, Arg, Val , Lys, Ile, Phe, 0.752; Ala, Arg, Met, Lys, Ile, Phe, 0.752; Ala, Arg, Lys, Ile, Phe, Trp, 0.752; Cit, Arg, Tyr, Orn, Ile, Trp, 0.752 Cit, Tyr, Ile, Leu, Phe, Trp, 0.752; Ser, Asn, Gly, His, Tyr, Ile, 0.751; Ser, Asn, Gln, Ala, Lys, Ile, 0.751; Ser, Asn, Gln, Tyr , Ile, Trp, 0.751; Ser, Asn, Cit, Tyr, Ile, Phe, 0.751; Ser, Asn, Arg, Pro, Tyr, Lys, 0.751; Ser, Asn, Arg, Tyr, Leu, Phe, 0.751; , Asn, Pro, Tyr, Leu, Phe, 0.751; Ser, Asn, Tyr, Leu, Phe, Trp, 0.751; Ser, Gly, Gln, Cit, Tyr, Leu, 0.751; Ser, Gly, Gln, Tyr, Val, Phe, 0.751; Ser, Gly, His, Tyr, Met, Ile, 0.751; Ser, Gly, Cit, Tyr, Ile, Phe, 0.751; Ser, Gln, Thr, Tyr, Lys, Leu, 0.751; Ser, Gln, Thr, Tyr, Ile, Trp, 0.751; Ser, Gln, Tyr, Val, Leu, Trp, 0.751; Met, Lys, Ile, Phe, 0.751; Ser, Gln, Met, Lys, Ile, Trp, 0.751; Ser, His, Arg, Tyr, Met, Ile, 0.751; Ser, His, Tyr, Met, Orn, Ile, Ser, His, Tyr, Ile, Leu, Phe, 0.751; Ser, Arg, Val, Lys, Ile, Phe, 0.751; Ser, Arg, Lys, Ile, Leu, Phe, 0.751; Asn, Gly, Gln, Ala, Cit, Ile, 0.751; Asn, Gly, Gln, Val, Orn, Leu, 0.751; Asn, Gly, Gln, Ile, Leu, Phe, 0.751; Asn, Gly, His, Tyr, Ile, Trp, 0.751; Asn, Gly, Thr, Arg, Tyr, Ile, 0.751; Asn, Gly, Thr, Orn, Lys, Ile, 0.751; Asn, Gly, Ala, Pro, Tyr, Leu, 0.751; Asn, Gly, Ala, Tyr, Val, Leu, 0.751; Asn, Gln, His, Cit, Orn, Leu, 0.751; Asn, Gln, Thr, Cit, Tyr, Ile, 0.751; Asn, Gln, Thr, Cit, Lys, Ile, 0.751; Gln, Thr, Lys, Ile, Trp, 0.751; Asn, Gln, Ala, Tyr, Ile, Trp, 0.751; Asn, Gln, Ala, Orn, Lys, Leu, 0.751; Asn, Gln, Cit, Tyr, Val, Leu, 0.751; Asn, Gln, Cit, Tyr, Ile, Trp, 0.751; Asn, Gln, Arg, Orn, Lys, Leu, 0.751; Asn, Gln, Pro, Tyr, Leu, Trp, 0.751; Asn, His, Thr, Met, Lys, Ile, 0.751; Asn, His, Ala, Cit, Ile, Leu, 0.751; Ala, Lys, Ile, Phe, 0.751; Asn, His, Cit, Pro, Ile, Phe, 0.751; Asn, His, Arg, Met, Ile, Phe, 0.751; Asn, His, Pro, Tyr, Lys, Ile, Asn, His, Tyr, Orn, Ile, Leu, 0.751; Asn, His, Tyr, Lys, Ile, Leu, 0.751; Asn, His, Val, Ile, Phe, Trp, 0.751; Asn, His, Met, Lys, Ile, Leu, 0.751; Asn, Thr, Cit, Lys, Ile, Phe, 0.751; Asn, Thr, Arg, Tyr, Leu, Phe, 0.751; Asn, Thr, Val, Lys, Ile, Leu, 0.751; Asn, Ala, Cit, Arg, Lys, Ile, 0.751; Asn, Ala, Arg, Lys, Ile, Trp, 0.751; Asn, Cit, Arg, Tyr, Met, Ile, 0.751; Asn, Arg, Tyr, Val, Lys, Leu, 0.751; Gly, Gln, His, Ala, Pro, Ile, 0.751; Gly, Gln, His, Ala, Val, Ile, 0.751; Gly, Gln, His, Cit, Lys, Ile, 0.751; Gln, His, Arg, Val, Ile, 0.751; Gly, Gln, His, Arg, Orn, Ile, 0.751; Gly, G ln, Thr, Arg, Tyr, Ile, 0.751; Gly, Gln, Thr, Met, Lys, Ile, 0.751; Gly, Gln, Cit, Tyr, Orn, Leu, 0.751; Gly, Gln, Cit, Tyr, Lys, Ile, 0.751; Gly, Gln, Cit, Orn, Ile, Trp, 0.751; Gly, Gln, Cit, Lys, Ile, Leu, 0.751; Gly, Gln, Pro, Tyr, Met, Ile, 0.751; Val, Lys, Ile, Trp, 0.751; Gly, Gln, Met, Orn, Lys, Ile, 0.751; Gly, His, Cit, Tyr, Val, Ile, 0.751; Gly, Thr, Tyr, Lys, Ile, Phe, Gly, Cit, Pro, Tyr, Lys, Ile, 0.751; Gly, Cit, Tyr, Lys, Ile, Phe, 0.751; Gly, Arg, Tyr, Val, Met, Lys, 0.751; Gly, Tyr, Val, Met, Ile, Phe, 0.751; Gly, Tyr, Ile, Leu, Phe, Trp, 0.751; Gln, His, Thr, Ala, Val, Ile, 0.751; Gln, His, Thr, Arg, Pro, Ile, 0.751; Gln, His, Thr, Arg, Val, Ile, 0.751; Gln, His, Thr, Met, Ile, Trp, 0.751; Gln, His, Ala, Arg, Orn, Ile, 0.751; Tyr, Leu, 0.751; Gln, His, Ala, Tyr, Lys, Ile, 0.751; Gln, His, Ala, Met, Ile, Leu, 0.751; Gln, His, Ala, Lys, Ile, Trp, 0.751; His, Cit, Pro, Lys, Ile, 0.751; Gln, His, Arg, Pro, Tyr, Lys, 0.751; Gln, Hi s, Arg, Met, Ile, Leu, 0.751; Gln, His, Arg, Ile, Leu, Trp, 0.751; Gln, His, Pro, Met, Orn, Ile, 0.751; Gln, His, Pro, Lys, Ile, Phe, 0.751; Gln, His, Tyr, Val, Phe, Trp, 0.751; Gln, His, Val, Ile, Leu, Trp, 0.751; Gln, Thr, Ala, Arg, Lys, Ile, 0.751; Arg, Tyr, Ile, Phe, 0.751; Gln, Thr, Val, Lys, Ile, Trp, 0.751; Gln, Ala, Cit, Val, Ile, Leu, 0.751; Gln, Ala, Pro, Tyr, Leu, Phe, Gln, Ala, Tyr, Orn, Leu, Trp, 0.751; Gln, Cit, Pro, Tyr, Orn, Ile, 0.751; Gln, Cit, Orn, Ile, Leu, Phe, 0.751; Ile, Leu, Trp, 0.751; Gln, Cit, Lys, Ile, Phe, Trp, 0.751; Gln, Arg, Pro, Lys, Ile, Phe, 0.751; Gln, Pro, Tyr, Val, Lys, Trp, 0.751; Gln, Pro, Tyr, Met, Ile, Leu, 0.751; Gln, Val, Lys, Ile, Leu, Trp, 0.751; Gln, Orn, Lys, Ile, Phe, Trp, 0.751; His, Thr, Ala, Tyr, His, Thr, Arg, Tyr, Met, Ile, 0.751; His, Thr, Arg, Tyr, Lys, Ile, 0.751; His, Thr, Pro, Tyr, Met, Ile, 0.751; Cit, Arg, Tyr, Ile, Phe, 0.751; Thr, Arg, Tyr, Val, Lys, Ile, 0.751; Thr, Arg , Lys, Ile, Phe, Trp, 0.751; Thr, Tyr, Met, Lys, Leu, Phe, 0.751; Thr, Tyr, Ile, Leu, Phe, Trp, 0.751; Ala, Cit, Tyr, Ile, Leu, Phe Cit, Tyr, Val, Lys, Ile, Trp, 0.751; Arg, Pro, Tyr, Met, Orn, Lys, 0.751; Tyr, Lys, Ile, Leu, Phe, Trp, 0.751; Ser, Asn, Gln , Tyr, Orn, Ile, 0.75; Ser, Asn, Lys, Ile, Leu, Phe, 0.75; Ser, Gly, Gln, His, Cit, Ile, 0.75; Ser, Gly, His, Arg, Tyr, Ile, 0.75 Ser, Gly, Cit, Tyr, Met, Ile, 0.75; Ser, Gln, His, Arg, Ile, Leu, 0.75; Ser, Gln, His, Pro, Tyr, Leu, 0.75; Ser, Gln, His, Tyr , Val, Leu, 0.75; Ser, Gln, His, Val, Lys, Ile, 0.75; Ser, Gln, Ala, Tyr, Leu, Trp, 0.75; Ser, Gln, Cit, Tyr, Val, Ile, 0.75; , Gln, Cit, Tyr, Orn, Ile, 0.75; Ser, Gln, Tyr, Met, Leu, Trp, 0.75; Ser, His, Pro, Tyr, Met, Ile, 0.75; Ser, Cit, Tyr, Val, Orn Ser, Arg, Orn, Lys, Ile, Phe, 0.75; Asn, Gly, Ala, Arg, Tyr, Ile, 0.75; Asn, Gly, Tyr, Val, Leu, Phe, 0.75; Asn, Gln , Val, Lys, Ile, Trp, 0.75; Asn, Thr, Cit, Tyr, Met, Ile, 0.75; Asn, Thr, Arg, Pro, Lys, Ile, Asn, Thr, Val, Met, Lys, Ile, 0.75; Asn, Ala, Cit, Met, Lys, Ile, 0.75; Asn, Ala, Cit, Lys, Ile, Trp, 0.75; Asn, Ala, Tyr, Lys, Leu, Trp, 0.75; Asn, Cit, Orn, Lys, Ile, Trp, 0.75; Asn, Arg, Pro, Lys, Ile, Leu, 0.75; Gly, Gln, His, Arg, Pro, Ile, 0.75; Gly, Gln, Thr, Lys, Ile, Phe, 0.75; Gly, Gln, Ala, Tyr, Orn, Ile, 0.75; Gly, Thr, Tyr, Lys, Leu, Phe, 0.75; Gly, Cit, Tyr, Val, Met, Ile, 0.75; Gly, Tyr, Lys, Ile, Leu, Phe, 0.75; Gln, His, Cit, Arg, Lys, Ile, 0.75; Gln, His, Pro, Val, Ile, Trp, 0.75; His, Val, Lys, Ile, Trp, 0.75; Gln, His, Met, Orn, Ile, Trp, 0.75; Gln, Thr, Ala, Tyr, Leu, Phe, 0.75; Gln, Thr, Cit, Ile, Leu, Phe, 0.75; Gln, Thr, Tyr, Val, Lys, Leu, 0.75; Gln, Cit, Tyr, Met, Orn, Leu, 0.75; Gln, Arg, Pro, Tyr, Ile, Phe, 0.75; Tyr, Val, Ile, Trp, 0.75; Gln, Tyr, Val, Orn, Ile, Leu, 0.75; His, Arg, Orn, Ile, Leu, Phe, 0.75; Thr, Ala, Tyr, Lys, Ile, Phe, Ala, Arg, Tyr, Lys, Leu, Trp, 0.75; Arg, Pro, Orn, Lys, Ile, Phe, 0.75; Arg, Tyr, Orn, Lys, L eu, Phe, 0.75; Tyr, Met, Ile, Leu, Phe, Trp, 0.75; Ser, Asn, Gln, Pro, Tyr, Ile, 0.75; Ser, Asn, Gln, Met, Lys, Leu, 0.75; Asn, His, Lys, Ile, Trp, 0.75; Ser, Asn, Thr, Tyr, Ile, Leu, 0.75; Ser, Asn, Arg, Val, Lys, Ile, 0.75; Ser, Gln, His, Thr, Ile, Phe, 0.75; Ser, Gln, His, Cit, Lys, Ile, 0.75; Ser, Gln, Thr, Lys, Leu, Phe, 0.75; Ser, Gln, Arg, Tyr, Ile, Leu, 0.75; Arg, Tyr, Leu, Phe, 0.75; Ser, Gln, Tyr, Val, Lys, Trp, 0.75; Ser, His, Tyr, Met, Ile, Leu, 0.75; Ser, Thr, Cit, Tyr, Ile, Phe, Ser, Thr, Arg, Lys, Ile, Trp, 0.75; Ser, Arg, Tyr, Ile, Leu, Trp, 0.75; Ser, Arg, Met, Lys, Ile, Trp, 0.75; Ser, Tyr, Met, Ile, Leu, Phe, 0.75; Asn, Gly, Gln, His, Orn, Leu, 0.75; Asn, Gly, Gln, Cit, Pro, Ile, 0.75; Asn, Gly, Gln, Tyr, Val, Trp, 0.75; Asn, Gly, His, Cit, Tyr, Leu, 0.75; Asn, Gly, Thr, Tyr, Met, Leu, 0.75; Asn, Gly, Thr, Val, Lys, Ile, 0.75; Asn, Gly, Thr, Met, Lys, Ile, 0.75; Asn, Gly, Lys, Ile, Leu, Phe, 0.75; Asn, Gln, Thr, Arg, Leu, Phe, 0.75; Asn, Gln, Ala , Cit, Ile, Leu, 0.75; Asn, Gln, Cit, Arg, Tyr, Ile, 0.75; Asn, Gln, Cit, Pro, Tyr, Ile, 0.75; Asn, His, Ala, Arg, Ile, Phe, 0.75 Asn, His, Arg, Tyr, Orn, Leu, 0.75; Asn, His, Arg, Tyr, Leu, Phe, 0.75; Asn, His, Pro, Tyr, Orn, Ile, 0.75; Asn, His, Pro, Tyr , Ile, Leu, 0.75; Asn, His, Tyr, Val, Orn, Ile, 0.75; Asn, His, Tyr, Val, Lys, Ile, 0.75; Asn, His, Tyr, Met, Lys, Leu, 0.75; , His, Val, Met, Lys, Ile, 0.75; Asn, His, Met, Ile, Phe, Trp, 0.75; Asn, Thr, Lys, Ile, Leu, Trp, 0.75; Asn, Cit, Pro, Tyr, Met , Ile, 0.75; Asn, Arg, Tyr, Val, Orn, Lys, 0.75; Gly, Gln, His, Arg, Met, Ile, 0.75; Gly, Gln, His, Arg, Ile, Trp, 0.75; , His, Met, Lys, Ile, 0.75; Gly, Gln, Thr, Orn, Lys, Ile, 0.75; Gly, Gln, Ala, Tyr, Orn, Leu, 0.75; Gly, Gln, Cit, Pro, Tyr, Leu , 0.75; Gly, Gln, Pro, Tyr, Val, Ile, 0.75; Gly, Gln, Tyr, Val, Met, Phe, 0.75; Gly, Gln, Met, Lys, Ile, Trp, 0.75; , Tyr, Met, Ile, 0.75; Gly, Ala, Cit, Tyr, Ile, Phe, 0.75; Gln, His, Thr, Arg, Ile, Leu, 0.75; His, Ala, Cit, Lys, Ile, 0.75; Gln, His, Ala, Tyr, Val, Leu, 0.75; Gln, His, Ala, Lys, Ile, Phe, 0.75; Gln, His, Arg, Val, Met, Ile, 0.75; Gln, His, Pro, Tyr, Val, Trp, 0.75; Gln, Thr, Arg, Lys, Ile, Leu, 0.75; Gln, Thr, Tyr, Met, Ile, Leu, 0

Gln, Thr, Tyr, Orn, Leu, Trp, 0.75; Gln, Thr, Val, Lys, Leu, Phe, 0.75; Gln, Ala, Cit, Val, Lys, Ile, 0.75; Gln, Ala, Tyr , Val, Ile, Trp, 0.75; Gln, Ala, Tyr, Orn, Leu, Phe, 0.75; Gln, Cit, Tyr, Met, Leu, Trp, 0.75; Gln, Cit, Tyr, Orn, Lys, Ile, 0.75 Gln, Arg, Tyr, Met, Orn, Leu, 0.75; Gln, Pro, Tyr, Met, Ile, Trp, 0.75; Gln, Tyr, Orn, Lys, Leu, Trp, 0.75; Gln, Met, Lys, Ile , Leu, Trp, 0.75; Gln, Met, Lys, Ile, Phe, Trp, 0.75; His, Cit, Pro, Tyr, Lys, Ile, 0.75; His, Arg, Met, Lys, Ile, Leu, 0.75; , Arg, Lys, Ile, Leu, Phe, 0.75; Thr, Arg, Tyr, Lys, Leu, Phe, 0.75; Thr, Arg, Val, Lys, Ile, Phe, 0.75; Thr, Tyr, Lys, Leu, Phe Ala, Arg, Orn, Lys, Ile, Phe, 0.75; Ala, Tyr, Lys, Ile, Leu, Phe, 0.75; Arg, Pro , Tyr, Lys, Leu, Phe, 0.75
［６．アミノ酸を含む２変数の式］
Gln, Ile, 0.732, 0.693, 0.9%; Asn, Leu, 0.724, 0.680, 0.4%; Gln, Leu, 0.723, 0.684, 0.2%; Tyr, Ile, 0.719, 0.705, 7.0%; Asn, Ile, 0.717, 0.680, 2.9%; Cit, Ile, 0.717, 0.689, 0.9%; Ile, Phe, 0.716, 0.669, 2.2%; Leu, Phe, 0.716, 0.661, 0.4%; His, Ile, 0.713, 0.676, 2.4%; Lys, Ile, 0.711, 0.665, 4.4%; Tyr, Val, 0.710, 0.709, 6.1%; Arg, Ile, 0.708, 0.680, 2.8%; Met, Ile, 0.707, 0.678, 2.8%; Ile, Leu, 0.707, 0.673, 1.3%; Pro, Ile, 0.707, 0.675, 3.3%; Gly, Ile, 0.706, 0.673, 2.8%; Ala, Ile, 0.705, 0.675, 4.2%; Ala, Leu, 0.705, 0.663, 0.6%; Cit, Leu, 0.705, 0.664, 0.4%; Leu, Trp, 0.705, 0.663, 0.7%; Lys, Leu, 0.705, 0.655, 0.6%; Thr, Ile, 0.704, 0.675, 2.8%; Val, Leu, 0.704, 0.669, 0.7%; Ile, Trp, 0.703, 0.675, 2.8%; Orn, Ile, 0.703, 0.679, 2.6%; Val, Ile, 0.703, 0.680, 2.0%; Val, Lys, 0.703, 0.669, 2.4%; Met, Leu, 0.703, 0.662, 0.4%; Thr, Leu, 0.703, 0.664, 0.7%; Tyr, Leu, 0.703, 0.692, 3.9%; Orn, Leu, 0.702, 0.651, 0.9%; Gly, Leu, 0.702, 0.659, 0.7%; Gln, His, 0.701, 0.674, 0.9%; Ser, Ile, 0.700, 0.653, 4.8%; Ser, Leu, 0.700, 0.653, 0.6%; His, Leu, 0.698, 0.663, 0.2%; Arg, Leu, 0.697, 0.663, 0.4%; Gln, Val, 0.697, 0.682, 0.6%; Pro, Leu, 0.697, 0.665, 1.1%; Gln, Lys, 0.697, 0.633, 2.0%; His, Val, 0.697, 0.675, 1.3%; Asn, Val, 0.693, 0.676, 1.7%; Cit, Val, 0.690, 0.674, 1.1%; Val, Phe, 0.689, 0.677, 1.7%; Arg, Val, 0.688, 0.675, 2.6%; Gln, Pro, 0.688, 0.649, 6.1%; Val, Orn, 0.687, 0.668, 2.6%; Pro, Val, 0.686, 0.675, 2.8%; Val, Met, 0.686, 0.673, 2.8%; Gln, Met, 0.685, 0.658, 1.8%; Thr, Val, 0.682, 0.671, 2.0%; Val, Trp, 0.681, 0.669, 2.2%; Ala, Val, 0.680, 0.671, 2.6%; Gly, Val, 0.680, 0.670, 2.0%; Ser, Val, 0.678, 0.665, 2.0%; Gln, Tyr, 0.676, 0.712, 5.3%; Asn, Tyr, 0.668, 0.711, 8.5%; Asn, Lys, 0.667, 0.592, 2.9%; Arg, Tyr, 0.661, 0.703, 2.0%; Arg, Lys, 0.660, 0.603, 2.2%; His, Tyr, 0.657, 0.676, 1.3%; His, Phe, 0.653, 0.626, 0.4%; His, Met, 0.653, 0.622, 0.4%; His, Lys, 0.652, 0.614, 0.7%; His, Thr, 0.652, 0.626, 0.4%; Ser, His, 0.651, 0.649, 0.4%; Gly, His, 0.650, 0.631, 0.4%; Asn, His, 0.647, 0.613, 0.6%; His, Cit, 0.647, 0.626, 0.0%; His, Orn, 0.646, 0.598, 0.9%; His, Ala, 0.644, 0.622, 1.7%; His, Pro, 0.643, 0.625, 1.7%; Gln, Ala, 0.640, 0.607, 1.8%; His, Arg, 0.640, 0.616, 0.2%; Pro, Lys, 0.639, 0.596, 7.5%; Cit, Tyr, 0.637, 0.693, 3.7%; His, Trp, 0.634, 0.621, 0.6%; Pro, Tyr, 0.634, 0.670, 11.4%; Tyr, Lys, 0.634, 0.656, 6.2%; Cit, Pro, 0.630, 0.603, 0.7%; Gln, Arg, 0.630, 0.610, 3.3%; Gly, Tyr, 0.630, 0.686, 9.0%; Gln, Phe, 0.629, 0.633, 3.9%; Gly, Pro, 0.628, 0.616, 5.9%; Gln, Thr, 0.627, 0.597, 4.0%; Gly, Gln, 0.627, 0.608, 2.9%; Asn, Gln, 0.627, 0.608, 2.4%; Ala, Pro, 0.626, 0.603, 3.3%; Gln, Cit, 0.625, 0.593, 2.2%; Tyr, Met, 0.625, 0.687, 9.7%; Tyr, Phe, 0.625, 0.680, 7.9%; Ser, Tyr, 0.624, 0.701, 10.7%; Ala, Tyr, 0.623, 0.665, 9.7%; Asn, Ala, 0.623, 0.589, 0.7%; Thr, Tyr, 0.623, 0.688, 15.3%; Asn, Pro, 0.622, 0.592, 1.8%; Ser, Gln, 0.622, 0.586, 2.0%; Ser, Pro, 0.622, 0.592, 6.8%; Gln, Trp, 0.621, 0.628, 1.1%; Lys, Trp, 0.621, 0.589, 2.2%; Thr, Pro, 0.621, 0.595, 6.4%; Tyr, Orn, 0.621, 0.676, 9.2%; Tyr, Trp, 0.618, 0.670, 6.6%; Arg, Pro, 0.617, 0.597, 3.3%; Pro, Trp, 0.615, 0.612, 2.9%; Pro, Phe, 0.613, 0.601, 6.6%; Asn, Trp, 0.613, 0.617, 0.4%; Pro, Orn, 0.613, 0.575, 8.5%; Cit, Lys, 0.612, 0.568, 2.2%; Gly, Lys, 0.611, 0.589, 4.6%; Ala, Trp, 0.611, 0.599, 1.5%; Thr, Lys, 0.610, 0.555, 3.5%; Ser, Lys, 0.608, 0.599, 2.2%; Ala, Cit, 0.607, 0.586, 0.7%; Gly, Ala, 0.607, 0.608, 1.8%; Gln, Orn, 0.606, 0.580, 5.0%; Pro, Met, 0.605, 0.595, 4.0%; Asn, Met, 0.604, 0.600, 0.9%; Ala, Arg, 0.603, 0.588, 1.5%; Ala, Lys, 0.603, 0.560, 6.4%; Met, Lys, 0.601, 0.557, 4.0% [6. Bivariate formula containing amino acids]
Gln, Ile, 0.732, 0.693, 0.9%; Asn, Leu, 0.724, 0.680, 0.4%; Gln, Leu, 0.723, 0.684, 0.2%; Tyr, Ile, 0.719, 0.705, 7.0%; Cit, Ile, 0.717, 0.689, 0.9%; Ile, Phe, 0.716, 0.669, 2.2%; Leu, Phe, 0.716, 0.661, 0.4%; His, Ile, 0.713, 0.676, 2.4%; Arg, Ile, 0.708, 0.680, 2.8%; Met, Ile, 0.707, 0.678, 2.8%; Ile, Leu, 0.707, 0.673 Pro, Ile, 0.707, 0.675, 3.3%; Gly, Ile, 0.706, 0.673, 2.8%; Ala, Ile, 0.705, 0.675, 4.2%; Leu, 0.705, 0.664, 0.4%; Leu, Trp, 0.705, 0.663, 0.7%; Lys, Leu, 0.705, 0.655, 0.6%; Thr, Ile, 0.704, 0.675, 2.8%; Ile, Trp, 0.703, 0.675, 2.8%; Orn, Ile, 0.703, 0.679, 2.6%; Val, Ile, 0.703, 0.680, 2.0%; Val, Lys, 0.703, 0.669, 2.4%; Thr, Leu, 0.703, 0.664, 0.7%; Tyr, Leu, 0.703, 0.692, 3.9%; Orn, Leu, 0.702, 0.651, 0.9%; Gly, Leu, 0.702, 0.659, 0.7 %; Gln, His, 0.701, 0.674, 0.9%; Ser, Ile, Ser, Leu, 0.700, 0.653, 0.6%; His, Leu, 0.698, 0.663, 0.2%; Arg, Leu, 0.697, 0.663, 0.4%; Gln, Val, 0.697, 0.682, 0.6% Pro, Leu, 0.697, 0.665, 1.1%; Gln, Lys, 0.697, 0.633, 2.0%; His, Val, 0.697, 0.675, 1.3%; Asn, Val, 0.693, 0.676, 1.7%; , 0.674, 1.1%; Val, Phe, 0.689, 0.677, 1.7%; Arg, Val, 0.688, 0.675, 2.6%; Gln, Pro, 0.688, 0.649, 6.1%; Pro, Val, 0.686, 0.675, 2.8%; Val, Met, 0.686, 0.673, 2.8%; Gln, Met, 0.685, 0.658, 1.8%; Thr, Val, 0.682, 0.671, 2.0%; Ala, Val, 0.680, 0.671, 2.6%; Gly, Val, 0.680, 0.670, 2.0%; Ser, Val, 0.678, 0.665, 2.0%; Gln, Tyr, 0.676, 0.712, 5.3%; , Tyr, 0.668, 0.711, 8.5%; Asn, Lys, 0.667, 0.592, 2.9%; Arg, Tyr, 0.661, 0.703, 2.0%; Arg, Lys, 0.660, 0.603, 2.2%; His, Phe, 0.653, 0.626, 0.4%; His, Met, 0.653, 0.622, 0.4%; His, Lys, 0.652, 0.614, 0.7%; His, Thr, 0.652, 0.626, 0.4%; His, 0.651, 0.649, 0.4%; Gly, His, 0.650, 0.6 31, 0.4%; Asn, His, 0.647, 0.613, 0.6%; His, Cit, 0.647, 0.626, 0.0%; His, Orn, 0.646, 0.598, 0.9%; , Pro, 0.643, 0.625, 1.7%; Gln, Ala, 0.640, 0.607, 1.8%; His, Arg, 0.640, 0.616, 0.2%; Pro, Lys, 0.639, 0.596, 7.5%; His, Trp, 0.634, 0.621, 0.6%; Pro, Tyr, 0.634, 0.670, 11.4%; Tyr, Lys, 0.634, 0.656, 6.2%; Cit, Pro, 0.630, 0.603, 0.7%; Arg, 0.630, 0.610, 3.3%; Gly, Tyr, 0.630, 0.686, 9.0%; Gln, Phe, 0.629, 0.633, 3.9%; Gly, Pro, 0.628, 0.616, 5.9%; Gly, Gln, 0.627, 0.608, 2.9%; Asn, Gln, 0.627, 0.608, 2.4%; Ala, Pro, 0.626, 0.603, 3.3%; Gln, Cit, 0.625, 0.593, 2.2%; , 0.625, 0.687, 9.7%; Tyr, Phe, 0.625, 0.680, 7.9%; Ser, Tyr, 0.624, 0.701, 10.7%; Ala, Tyr, 0.623, 0.665, 9.7%; %; Thr, Tyr, 0.623, 0.688, 15.3%; Asn, Pro, 0.622, 0.592, 1.8%; Ser, Gln, 0.622, 0.586, 2.0%; Ser, Pro, 0.622, 0.592, 6.8%; 0.621, 0.628, 1.1%; Lys, Trp, 0.621, 0.589, 2.2 %; Thr, Pro, 0.621, 0.595, 6.4%; Tyr, Orn, 0.621, 0.676, 9.2%; Tyr, Trp, 0.618, 0.670, 6.6%; Arg, Pro, 0.617, 0.597, 3.3%; Pro, Phe, 0.613, 0.601, 6.6%; Asn, Trp, 0.613, 0.617, 0.4%; Pro, Orn, 0.613, 0.575, 8.5%; Cit, Lys, 0.612, 0.568, 2.2% Gly, Lys, 0.611, 0.589, 4.6%; Ala, Trp, 0.611, 0.599, 1.5%; Thr, Lys, 0.610, 0.555, 3.5%; Ser, Lys, 0.608, 0.599, 2.2%; , 0.586, 0.7%; Gly, Ala, 0.607, 0.608, 1.8%; Gln, Orn, 0.606, 0.580, 5.0%; Pro, Met, 0.605, 0.595, 4.0%; Ala, Arg, 0.603, 0.588, 1.5%; Ala, Lys, 0.603, 0.560, 6.4%; Met, Lys, 0.601, 0.557, 4.0%
［７．アミノ酸を含む３変数の式］
Gln, His, Ile, 0.752, 0.709, 1.1%; Gln, Lys, Ile, 0.745, 0.683, 0.9%; Asn, Lys, Ile, 0.744, 0.672, 2.6%; Cit, Tyr, Ile, 0.741, 0.717, 4.0%; Gln, Leu, Phe, 0.741, 0.678, 0.0%; Gln, Cit, Ile, 0.740, 0.698, 0.4%; Gln, Lys, Leu, 0.740, 0.681, 0.2%; Gln, Tyr, Leu, 0.740, 0.720, 2.8%; Asn, Gln, Ile, 0.739, 0.693, 0.9%; Gln, Ile, Phe, 0.739, 0.688, 0.9%; Gln, Tyr, Ile, 0.738, 0.724, 5.3%; Asn, Gln, Leu, 0.737, 0.690, 0.2%; Asn, His, Ile, 0.737, 0.696, 1.1%; Gln, Ile, Leu, 0.736, 0.696, 0.2%; Gln, Orn, Leu, 0.736, 0.674, 0.2%; Arg, Lys, Ile, 0.735, 0.674, 2.0%; Arg, Tyr, Lys, 0.735, 0.699, 4.4%; Gln, His, Tyr, 0.735, 0.727, 0.9%; Tyr, Met, Ile, 0.735, 0.719, 6.2%; Asn, Lys, Leu, 0.733, 0.671, 0.6%; Asn, Tyr, Leu, 0.733, 0.718, 2.8%; Gln, Pro, Ile, 0.733, 0.693, 1.1%; Asn, Val, Lys, 0.732, 0.677, 1.5%; Tyr, Ile, Phe, 0.732, 0.708, 6.8%; Gln, Ile, Trp, 0.731, 0.690, 0.9%; Gln, Val, Ile, 0.731, 0.697, 0.6%; Gln, Arg, Ile, 0.731, 0.692, 0.7%; His, Ile, Phe, 0.730, 0.676, 0.9%; Tyr, Leu, Phe, 0.730, 0.705, 2.0%; Gly, Gln, Ile, 0.730, 0.678, 0.9%; Asn, Tyr, Ile, 0.730, 0.716, 8.6%; Gln, Orn, Ile, 0.730, 0.682, 1.5%; Asn, Ile, Leu, 0.729, 0.685, 0.6%; Gln, Ala, Leu, 0.729, 0.680, 0.2%; Asn, Cit, Ile, 0.728, 0.691, 0.4%; Asn, Gly, Leu, 0.728, 0.675, 0.4%; Gln, Ala, Ile, 0.728, 0.687, 1.5%; Gln, Val, Lys, 0.727, 0.682, 0.6%; Gly, Gln, Leu, 0.727, 0.677, 0.2%; Asn, Leu, Phe, 0.726, 0.673, 0.4%; Gln, Thr, Ile, 0.726, 0.682, 1.5%; Ser, Gln, Ile, 0.726, 0.661, 2.6%; Ser, Gln, Leu, 0.726, 0.669, 0.2%; Arg, Tyr, Ile, 0.726, 0.715, 5.5%; Asn, Tyr, Val, 0.726, 0.722, 7.4%; Asn, His, Val, 0.725, 0.693, 0.2%; Gln, Met, Ile, 0.725, 0.689, 1.3%; His, Tyr, Ile, 0.724, 0.701, 5.5%; Gln, His, Lys, 0.724, 0.671, 1.5%; Gln, Leu, Trp, 0.724, 0.687, 0.0%; Ile, Leu, Phe, 0.724, 0.673, 0.6%; Gln, His, Pro, 0.723, 0.691, 2.2%; Gln, Pro, Leu, 0.723, 0.688, 0.2%; Gln, Tyr, Val, 0.723, 0.720, 6.6%; Cit, Ile, Phe, 0.723, 0.681, 0.7%; Gln, Thr, Leu, 0.723, 0.682, 0.2%; Gln, Arg, Leu, 0.722, 0.681, 0.2%; Tyr, Met, Leu, 0.722, 0.711, 4.2%; Asn, Ile, Trp, 0.721, 0.682, 1.5%; Asn, Thr, Ile, 0.721, 0.679, 2.2%; Cit, Lys, Ile, 0.721, 0.674, 1.7%; Gln, His, Leu, 0.721, 0.694, 0.4%; Met, Lys, Ile, 0.721, 0.666, 2.6%; Tyr, Ile, Trp, 0.721, 0.706, 9.4%; Val, Ile, Phe, 0.721, 0.681, 1.3%; Asn, Ala, Ile, 0.721, 0.681, 2.0%; Asn, Ile, Phe, 0.721, 0.675, 1.5%; Asn, Orn, Leu, 0.721, 0.668, 0.7%; Ala, Tyr, Ile, 0.720, 0.706, 7.0%; Arg, Tyr, Leu, 0.720, 0.705, 2.2%; Asn, Met, Leu, 0.720, 0.680, 0.6%; Gln, Cit, Leu, 0.720, 0.678, 0.2%; Tyr, Orn, Ile, 0.720, 0.716, 7.5%; Asn, Leu, Trp, 0.719, 0.678, 0.4%; Cit, Arg, Ile, 0.719, 0.686, 0.9%; Cit, Met, Ile, 0.719, 0.690, 1.8%; Cit, Tyr, Val, 0.719, 0.712, 4.6%; Gln, Met, Leu, 0.719, 0.684, 0.2%; Gly, Tyr, Ile, 0.719, 0.700, 7.7%; Ser, Asn, Leu, 0.719, 0.662, 0.6%; Thr, Tyr, Ile, 0.719, 0.712, 10.7%; Pro, Tyr, Ile, 0.719, 0.706, 7.0%; Ala, Cit, Ile, 0.718, 0.686, 3.3%; Arg, Val, Lys, 0.718, 0.669, 1.7%; Asn, Thr, Leu, 0.718, 0.674, 0.6%; Cit, Pro, Ile, 0.718, 0.687, 1.8%; Lys, Ile, Phe, 0.718, 0.661, 1.3%; Arg, Ile, Leu, 0.717, 0.680, 0.9%; Asn, His, Leu, 0.717, 0.682, 0.2%; Asn, Pro, Leu, 0.717, 0.679, 0.6%; Asn, Val, Leu, 0.717, 0.680, 0.6%; Asn, Gly, Ile, 0.717, 0.676, 2.6%; Asn, Orn, Ile, 0.717, 0.675, 2.9%; Gln, His, Val, 0.717, 0.698, 0.2%; Gln, Val, Leu, 0.717, 0.685, 0.2%; His, Arg, Ile, 0.717, 0.683, 0.9%; His, Met, Ile, 0.717, 0.678, 1.7%; Tyr, Val, Ile, 0.717, 0.706, 6.1%; Ala, Ile, Phe, 0.716, 0.666, 2.2%; Asn, Val, Ile, 0.716, 0.686, 1.3%; Ser, Asn, Ile, 0.716, 0.652, 3.1%; Tyr, Val, Met, 0.716, 0.720, 7.9%; Gly, Cit, Ile, 0.716, 0.681, 1.3%; His, Tyr, Val, 0.716, 0.707, 4.6%; Lys, Leu, Phe, 0.716, 0.656, 0.4%; Thr, Cit, Ile, 0.716, 0.683, 1.5%; Asn, Ala, Leu, 0.715, 0.673, 0.6%; Asn, Arg, Ile, 0.715, 0.683, 2.9%; Asn, Arg, Leu, 0.715, 0.677, 0.4%; Asn, Cit, Leu, 0.715, 0.675, 0.4%; Cit, Ile, Trp, 0.715, 0.691, 0.9%; Cit, Orn, Ile, 0.715, 0.668, 1.7%; His, Leu, Phe, 0.715, 0.664, 0.0%; Thr, Ile, Phe, 0.715, 0.668, 2.2%; Thr, Leu, Phe, 0.715, 0.660, 0.4%; Tyr, Lys, Ile, 0.715, 0.692, 7.7%; Ala, Met, Ile, 0.714, 0.675, 3.5%; Arg, Lys, Leu, 0.714, 0.660, 0.4%; Arg, Val, Ile, 0.714, 0.686, 2.8%; Cit, Val, Ile, 0.714, 0.688, 0.7%; Gly, Cit, Leu, 0.714, 0.661, 0.4%; Gly, His, Ile, 0.714, 0.677, 2.4%; Gly, Ile, Phe, 0.714, 0.669, 2.2%; Orn, Ile, Phe, 0.714, 0.671, 2.2%; Pro, Ile, Phe, 0.714, 0.666, 1.8%; Val, Leu, Phe, 0.714, 0.667, 0.6%; Ala, Arg, Ile, 0.714, 0.678, 2.4%; Arg, Leu, Phe, 0.714, 0.665, 0.2%; Asn, Met, Ile, 0.714, 0.680, 2.2%; Cit, Tyr, Leu, 0.714, 0.697, 2.2%; Cit, Val, Leu, 0.714, 0.671, 0.6%; Gly, Leu, Phe, 0.714, 0.658, 0.4%; Lys, Ile, Leu, 0.714, 0.667, 2.0%; Arg, Ile, Phe, 0.713, 0.674, 2.0%; Asn, Pro, Ile, 0.713, 0.679, 2.6%; Cit, Ile, Leu, 0.713, 0.679, 0.6%; Gly, Tyr, Val, 0.713, 0.706, 5.9%; His, Cit, Ile, 0.713, 0.681, 1.5%; His, Lys, Ile, 0.713, 0.670, 3.9%; His, Pro, Ile, 0.713, 0.676, 2.4%; Val, Lys, Ile, 0.713, 0.671, 3.1%; His, Ala, Ile, 0.712, 0.678, 2.6%; His, Ile, Leu, 0.712, 0.678, 2.0%; His, Orn, Ile, 0.712, 0.677, 2.4%; Ile, Leu, Trp, 0.712, 0.676, 1.3%; Ser, Tyr, Ile, 0.712, 0.698, 7.0%; Ala, Leu, Trp, 0.712, 0.668, 1.1%; Ala, Met, Leu, 0.712, 0.669, 0.9%; Arg, Tyr, Val, 0.712, 0.717, 4.6%; His, Ile, Trp, 0.712, 0.679, 2.9%; Met, Ile, Phe, 0.712, 0.669, 1.8%; Ser, His, Ile, 0.712, 0.666, 3.5%; Tyr, Ile, Leu, 0.712, 0.695, 5.0%; Gln, His, Ala, 0.711, 0.679, 1.1%; Gly, Tyr, Leu, 0.711, 0.691, 3.9%; Pro, Tyr, Val, 0.711, 0.709, 6.1%; Ser, Cit, Ile, 0.711, 0.663, 2.6%; Tyr, Val, Phe, 0.711, 0.710, 6.1%; Val, Leu, Trp, 0.711, 0.670, 0.9%; Gln, His, Orn, 0.710, 0.665, 0.9%; Gly, Lys, Ile, 0.710, 0.665, 4.4%; Leu, Phe, Trp, 0.710, 0.660, 0.4%; Lys, Ile, Trp, 0.710, 0.662, 4.4%; Lys, Leu, Trp, 0.710, 0.660, 0.9%; Pro, Leu, Phe, 0.710, 0.665, 0.7%; Ser, Leu, Phe, 0.710, 0.654, 0.6%; Ala, Ile, Leu, 0.710, 0.673, 3.5%; Ala, Tyr, Val, 0.710, 0.708, 6.1%; Met, Lys, Leu, 0.710, 0.658, 0.7%; Pro, Met, Ile, 0.710, 0.678, 3.3%; Thr, Lys, Ile, 0.710, 0.665, 3.7%; Ala, Leu, Phe, 0.709, 0.662, 0.2%; Gln, His, Met, 0.709, 0.679, 0.7%; Met, Ile, Leu, 0.709, 0.675, 1.1%; Met, Leu, Phe, 0.709, 0.659, 0.4%; Pro, Ile, Leu, 0.709, 0.673, 1.3%; Tyr, Leu, Trp, 0.709, 0.701, 4.4%; Tyr, Lys, Leu, 0.709, 0.690, 4.0%; Ala, Orn, Ile, 0.709, 0.683, 3.9%; Ala, Tyr, Leu, 0.709, 0.689, 3.1%; Arg, Orn, Ile, 0.709, 0.666, 3.3%; Arg, Pro, Ile, 0.709, 0.682, 3.3%; Gly, Lys, Leu, 0.709, 0.655, 0.6%; Gly, Val, Leu, 0.709, 0.669, 0.7%; His, Thr, Ile, 0.709, 0.677, 2.9%; His, Val, Ile, 0.709, 0.681, 2.4%; Ser, Ile, Phe, 0.709, 0.646, 2.8%; Tyr, Val, Trp, 0.709, 0.712, 8.5%; Val, Lys, Leu, 0.709, 0.665, 0.7%; Val, Lys, Phe, 0.709, 0.668, 1.1%; Ala, Lys, Ile, 0.708, 0.663, 5.5%; Arg, Orn, Leu, 0.708, 0.651, 1.1%; Gly, Arg, Ile, 0.708, 0.672, 3.1%; Gly, Ile, Leu, 0.708, 0.669, 1.1%; Gly, Met, Ile, 0.708, 0.674, 2.6%; His, Cit, Val, 0.708, 0.679, 1.1%; His, Leu, Trp, 0.708, 0.665, 0.7%; His, Val, Lys, 0.708, 0.669, 2.0%; His, Val, Phe, 0.708, 0.680, 0.6%; Orn, Leu, Phe, 0.708, 0.653, 0.6%; Orn, Lys, Ile, 0.708, 0.673, 3.3%; Pro, Lys, Ile, 0.708, 0.664, 5.5%; Pro, Tyr, Leu, 0.708, 0.692, 3.9%; Ser, Leu, Trp, 0.708, 0.654, 0.6%; Tyr, Val, Leu, 0.708, 0.699, 4.6%; Arg, Pro, Leu, 0.707, 0.671, 0.9%; Cit, Leu, Trp, 0.707, 0.666, 0.6%; Gly, Orn, Ile, 0.707, 0.678, 2.6%; His, Ala, Leu, 0.707, 0.664, 0.4%; His, Lys, Leu, 0.707, 0.657, 0.6%; Met, Orn, Ile, 0.707, 0.678, 2.4%; Thr, Ala, Leu, 0.707, 0.665, 0.9%; Thr, Cit, Leu, 0.707, 0.665, 0.4%; Thr, Tyr, Val, 0.707, 0.715, 11.2%; Tyr, Val, Lys, 0.707, 0.699, 5.9%; Ala, Arg, Leu, 0.707, 0.668, 1.1%; Arg, Ile, Trp, 0.707, 0.682, 2.8%; Arg, Met, Ile, 0.707, 0.679, 2.4%; Cit, Lys, Leu, 0.707, 0.655, 0.6%; Gly, Ile, Trp, 0.707, 0.675, 2.9%; His, Val, Leu, 0.707, 0.672, 0.6%; Ile, Phe, Trp, 0.707, 0.668, 2.4%; Orn, Lys, Leu, 0.707, 0.648, 0.6%; Ser, Val, Leu, 0.707, 0.662, 0.7%; Thr, Ala, Ile, 0.707, 0.676, 3.9%; Thr, Ile, Leu, 0.707, 0.674, 1.3%; Tyr, Val, Orn, 0.707, 0.710, 6.1%; Val, Orn, Leu, 0.707, 0.661, 1.1%; Ala, Cit, Leu, 0.706, 0.666, 0.7%; Gly, Arg, Leu, 0.706, 0.662, 0.4%; Met, Ile, Trp, 0.706, 0.678, 2.0%; Orn, Ile, Trp, 0.706, 0.679, 2.8%; Ser, Lys, Leu, 0.706, 0.652, 0.6%; Ala, Val, Ile, 0.705, 0.681, 4.2%; Gly, Ala, Ile, 0.705, 0.675, 4.2%; Gly, Leu, Trp, 0.705, 0.662, 0.6%; Gly, Orn, Leu, 0.705, 0.651, 0.9%; Gly, Pro, Ile, 0.705, 0.675, 3.7%; His, Cit, Leu, 0.705, 0.667, 0.2%; Pro, Met, Leu, 0.705, 0.669, 0.9%; Ser, Ile, Leu, 0.705, 0.650, 2.2%; Val, Ile, Leu, 0.705, 0.676, 1.3%; Val, Ile, Trp, 0.705, 0.682, 1.8%; Cit, Leu, Phe, 0.705, 0.657, 0.2%; Cit, Met, Leu, 0.705, 0.664, 0.4%; Cit, Val, Lys, 0.705, 0.668, 1.7%; Gly, Thr, Ile, 0.705, 0.673, 2.6%; His, Val, Orn, 0.705, 0.673, 1.5%; Orn, Leu, Trp, 0.705, 0.651, 1.3%; Ser, Ala, Leu, 0.705, 0.658, 0.6%; Ser, Cit, Leu, 0.705, 0.655, 0.4%; Ser, Lys, Ile, 0.705, 0.648, 5.0%; Ser, Tyr, Val, 0.705, 0.714, 5.9%; Thr, Leu, Trp, 0.705, 0.663, 0.6%; Thr, Orn, Ile, 0.705, 0.679, 2.6%; Val, Met, Ile, 0.705, 0.682, 2.0%; Val, Met, Lys, 0.705, 0.669, 2.0%; Ala, Ile, Trp, 0.704, 0.675, 4.2%; Ala, Pro, Ile, 0.704, 0.675, 4.0%; Arg, Pro, Lys, 0.704, 0.631, 6.1%; Gln, His, Thr, 0.704, 0.676, 0.7%; Gly, Ala, Leu, 0.704, 0.662, 0.6%; Gly, Met, Leu, 0.704, 0.658, 0.7%; Met, Orn, Leu, 0.704, 0.652, 0.7%; Orn, Ile, Leu, 0.704, 0.669, 1.3%; Pro, Ile, Trp, 0.704, 0.675, 3.9%; Pro, Orn, Ile, 0.704, 0.680, 2.8%; Ser, Met, Ile, 0.704, 0.646, 3.7%; Thr, Ile, Trp, 0.704, 0.677, 2.8%; Thr, Met, Ile, 0.704, 0.673, 2.9%; Thr, Val, Ile, 0.704, 0.680, 2.0%; Val, Lys, Trp, 0.704, 0.670, 2.4%; Val, Met, Leu, 0.704, 0.669, 0.7%; Gly, His, Leu, 0.703, 0.661, 0.2%; Gly, Thr, Leu, 0.703, 0.661, 0.7%; His, Val, Met, 0.703, 0.682, 1.5%; Pro, Leu, Trp, 0.703, 0.668, 1.3%; Ser, Gly, Leu, 0.703, 0.654, 0.6%; Ser, Orn, Leu, 0.703, 0.649, 0.9%; Thr, Arg, Ile, 0.703, 0.675, 3.1%; Thr, Met, Leu, 0.703, 0.661, 0.4%; Thr, Tyr, Leu, 0.703, 0.697, 6.4%; Thr, Val, Lys, 0.703, 0.668, 1.8%; Ala, Val, Leu, 0.703, 0.666, 0.6%; Gly, Pro, Leu, 0.703, 0.662, 1.1%; Gly, Val, Ile, 0.703, 0.678, 1.8%; Met, Leu, Trp, 0.703, 0.663, 0.6%; Pro, Val, Leu, 0.703, 0.671, 1.3%; Ser, Ala, Ile, 0.703, 0.653, 4.8%; Thr, Lys, Leu, 0.703, 0.657, 0.7%; Thr, Pro, Ile, 0.703, 0.676, 2.9%; Thr, Val, Leu, 0.703, 0.670, 0.7%; Asn, His, Tyr, 0.70

2, 0.708, 2.6%; Cit, Arg, Leu, 0.702, 0.664, 0.4%; His, Met, Leu, 0.702, 0.666, 0.2%; His, Tyr, Leu, 0.702, 0.691, 3.7%; Ser, Val, Lys, 0.702, 0.670, 2.4%; Tyr, Orn, Leu, 0.702, 0.693, 3.7%; Val, Orn, Ile, 0.702, 0.680, 2.0%; Ala, Lys, Leu, 0.702, 0.658, 0.6%; Arg, Val, Leu, 0.702, 0.669, 0.6%; Gln, Ala, Lys, 0.702, 0.635, 3.5%; Gln, His, Cit, 0.702, 0.675, 0.9%; His, Ala, Val, 0.702, 0.675, 2.2%; His, Val, Trp, 0.702, 0.678, 1.3%; Pro, Val, Ile, 0.702, 0.680, 2.8%; Ala, Orn, Leu, 0.701, 0.659, 0.6%; Asn, His, Lys, 0.701, 0.629, 1.7%; Gln, Tyr, Lys, 0.701, 0.710, 5.9%; Gly, Val, Lys, 0.701, 0.669, 2.4%; His, Orn, Leu, 0.701, 0.653, 0.4%; Ser, Ile, Trp, 0.701, 0.651, 4.6%; Ser, Val, Ile, 0.701, 0.660, 4.0%; Val, Orn, Lys, 0.701, 0.667, 2.4%; Cit, Pro, Leu, 0.700, 0.669, 0.6%; Gln, His, Arg, 0.700, 0.675, 0.9%; Gln, Pro, Tyr, 0.700, 0.723, 5.9%; Gly, Gln, His, 0.700, 0.674, 0.9%; His, Arg, Val, 0.700, 0.681, 0.6%; Ser, Arg, Leu, 0.700, 0.652, 0.6%; Ser, Met, Leu, 0.700, 0.651, 0.6%; Arg, Leu, Trp, 0.700, 0.666, 0.4%; Asn, Gln, Val, 0.700, 0.684, 0.6%; Cit, Orn, Leu, 0.700, 0.649, 0.9%; Ser, Arg, Ile, 0.700, 0.646, 2.6%; Ser, Gln, His, 0.700, 0.677, 0.9%; Asn, Val, Orn, 0.699, 0.673, 2.4%; Gln, His, Phe, 0.699, 0.674, 0.9%; Gln, Met, Lys, 0.699, 0.652, 2.4%; Gln, Pro, Lys, 0.699, 0.645, 3.9%; Gln, Val, Met, 0.699, 0.686, 0.7%; His, Arg, Leu, 0.699, 0.666, 0.2%; His, Pro, Leu, 0.699, 0.665, 0.7%; Pro, Lys, Leu, 0.699, 0.657, 1.7%; Pro, Orn, Leu, 0.699, 0.660, 1.5%; Ser, Gly, Ile, 0.699, 0.652, 4.2%; Ser, Thr, Ile, 0.699, 0.646, 4.0%; Thr, Pro, Leu, 0.699, 0.667, 1.5%; Gln, Val, Orn, 0.698, 0.674, 0.7%; Ser, His, Val, 0.698, 0.681, 1.3%; Ser, Tyr, Leu, 0.698, 0.693, 3.9%; Asn, Tyr, Lys, 0.698, 0.695, 8.8%; Asn, Val, Met, 0.698, 0.678, 1.5%; Gln, Cit, Val, 0.698, 0.683, 0.6%; Gln, Val, Phe, 0.698, 0.684, 0.4%; Gly, Gln, Val, 0.698, 0.682, 0.6%; His, Pro, Val, 0.698, 0.676, 1.3%; Ser, Pro, Ile, 0.698, 0.651, 5.0%; Ala, Pro, Leu, 0.697, 0.661, 0.7%; Arg, Pro, Val, 0.697, 0.680, 2.2%; Pro, Val, Phe, 0.697, 0.677, 1.3%; Ser, His, Leu, 0.697, 0.660, 0.4%; Ser, Pro, Leu, 0.697, 0.658, 1.1%; Thr, Arg, Leu, 0.697, 0.661, 0.4%; Asn, Gln, Lys, 0.697, 0.626, 2.2%; Asn, Val, Phe, 0.697, 0.679, 1.8%; Cit, Pro, Val, 0.697, 0.675, 1.3%; Gln, Thr, Val, 0.697, 0.682, 0.6%; Ser, Asn, Val, 0.697, 0.672, 1.3%; Ser, Orn, Ile, 0.697, 0.658, 4.4%; Thr, Orn, Leu, 0.697, 0.650, 1.1%; Asn, Cit, Val, 0.696, 0.675, 1.7%; Asn, Pro, Val, 0.696, 0.679, 1.7%; Gln, Arg, Val, 0.696, 0.683, 0.6%; Gln, Pro, Met, 0.696, 0.664, 1.7%; Gly, Gln, Lys, 0.696, 0.634, 2.2%; Pro, Val, Lys, 0.696, 0.664, 2.8%; Ser, Gln, Val, 0.696, 0.673, 0.6%; Asn, Arg, Val, 0.695, 0.679, 2.0%; Gln, Pro, Val, 0.695, 0.686, 0.9%; Ser, Thr, Leu, 0.695, 0.651, 0.6%; Gln, Orn, Lys, 0.695, 0.619, 2.0%; Gln, Val, Trp, 0.695, 0.682, 0.4%; Gly, His, Val, 0.695, 0.676, 1.3%; His, Thr, Leu, 0.694, 0.660, 0.2%; Arg, Val, Phe, 0.693, 0.677, 2.4%; Cit, Val, Phe, 0.693, 0.675, 1.1%; Gln, Cit, Pro, 0.693, 0.649, 2.4%; Arg, Met, Leu, 0.693, 0.663, 0.4%; Asn, Ala, Val, 0.693, 0.675, 2.2%; Asn, Gly, Val, 0.693, 0.676, 1.7%; Gln, Cit, Lys, 0.693, 0.633, 1.7%; His, Thr, Val, 0.693, 0.678, 1.7%; Asn, Tyr, Trp, 0.692, 0.705, 5.5%; Gln, Lys, Phe, 0.692, 0.637, 2.0%; Gly, Arg, Val, 0.692, 0.675, 2.2%; Gly, Cit, Val, 0.692, 0.671, 1.1%; Ser, Gln, Lys, 0.692, 0.639, 2.2%; Asn, Thr, Val, 0.691, 0.675, 1.7%; Asn, Val, Trp, 0.691, 0.675, 0.9%; Cit, Arg, Val, 0.691, 0.676, 1.8%; Val, Orn, Phe, 0.691, 0.667, 1.7%; Ala, Val, Lys, 0.691, 0.664, 2.6%; Asn, Gln, His, 0.691, 0.672, 0.9%; Cit, Val, Orn, 0.691, 0.657, 1.8%; Gln, Ala, Val, 0.691, 0.674, 1.7%; Gln, His, Trp, 0.691, 0.674, 0.6%; Thr, Val, Orn, 0.691, 0.667, 2.9%; Gln, Lys, Trp, 0.690, 0.648, 1.3%; Gln, Arg, Pro, 0.690, 0.650, 5.9%; Gln, Thr, Lys, 0.690, 0.634, 1.8%; Gln, Arg, Lys, 0.689, 0.629, 1.8%; Ala, Val, Phe, 0.688, 0.669, 1.8%; Gly, Gln, Pro, 0.688, 0.654, 5.0%; Gly, Val, Phe, 0.688, 0.675, 1.5%; His, Arg, Tyr, 0.688, 0.694, 0.6%; Val, Orn, Trp, 0.688, 0.667, 2.9%; Ala, Cit, Val, 0.688, 0.669, 1.5%; Cit, Val, Met, 0.688, 0.672, 1.8%; Cit, Val, Trp, 0.688, 0.672, 1.1%; Ser, Cit, Val, 0.688, 0.667, 1.1%; Thr, Val, Phe, 0.688, 0.675, 1.5%; Asn, Gln, Pro, 0.687, 0.651, 4.6%; Gly, Val, Orn, 0.687, 0.668, 2.9%; Ser, Pro, Val, 0.687, 0.668, 3.5%; Ser, Val, Orn, 0.687, 0.663, 2.8%; Ala, Arg, Val, 0.686, 0.672, 2.4%; Arg, Val, Orn, 0.686, 0.662, 3.1%; Gly, Pro, Val, 0.686, 0.675, 2.8%; Pro, Val, Met, 0.686, 0.675, 2.9%; Pro, Val, Orn, 0.686, 0.668, 3.3%; Thr, Cit, Val, 0.686, 0.669, 0.9%; Val, Met, Orn, 0.686, 0.665, 2.9%; Arg, Val, Met, 0.686, 0.674, 1.8%; Gly, Gln, Met, 0.686, 0.661, 1.8%; Ser, Arg, Val, 0.686, 0.666, 1.8%; Arg, Val, Trp, 0.685, 0.673, 1.7%; Gln, Thr, Met, 0.685, 0.654, 1.3%; Gln, Thr, Pro, 0.685, 0.639, 3.1%; Gly, Val, Met, 0.685, 0.672, 2.8%; Val, Met, Trp, 0.685, 0.673, 2.8%; Ser, Gln, Pro, 0.684, 0.629, 6.4%; Thr, Arg, Val, 0.684, 0.670, 2.4%; Ala, Val, Orn, 0.683, 0.667, 2.8%; Asn, His, Orn, 0.683, 0.616, 0.9%; Gln, Ala, Met, 0.683, 0.652, 2.4%; Gln, Met, Phe, 0.683, 0.657, 1.8%; Gln, Pro, Phe, 0.683, 0.662, 5.3%; Gly, Val, Trp, 0.683, 0.670, 2.2%; Ser, Gln, Met, 0.683, 0.658, 1.8%; Thr, Pro, Val, 0.683, 0.675, 3.1%; Asn, Lys, Trp, 0.683, 0.621, 1.5%; Gln, Tyr, Orn, 0.683, 0.701, 5.0%; Ser, Ala, Val, 0.683, 0.666, 2.6%; Ser, Thr, Val, 0.683, 0.666, 1.7%; Val, Met, Phe, 0.683, 0.671, 2.0%; Ser, Val, Phe, 0.683, 0.671, 0.9%; Arg, Orn, Lys, 0.682, 0.588, 4.4%; Gly, Ala, Val, 0.682, 0.671, 2.6%; Asn, Pro, Tyr, 0.681, 0.703, 11.4%; Gly, Thr, Val, 0.681, 0.671, 2.0%; Ala, Val, Trp, 0.681, 0.670, 2.6%; Asn, Gln, Tyr, 0.681, 0.718, 6.8%; Ala, Val, Met, 0.680, 0.671, 2.6%; His, Cit, Tyr, 0.680, 0.692, 0.4%; Pro, Val, Trp, 0.680, 0.673, 3.1%; Ser, Val, Met, 0.680, 0.666, 2.6%; Thr, Val, Trp, 0.680, 0.669, 1.5%; Ala, Pro, Val, 0.679, 0.671, 2.8%; Gln, Ala, Tyr, 0.679, 0.709, 7.0%; Gly, Gln, Tyr, 0.679, 0.710, 7.0%; His, Tyr, Met, 0.678, 0.702, 2.8%; Ser, Gly, Val, 0.678, 0.665, 2.0%; Thr, Val, Met, 0.678, 0.670, 2.4%; Val, Phe, Trp, 0.678, 0.673, 1.3%; Ser, Val, Trp, 0.677, 0.665, 2.2%; Asn, Ala, Tyr, 0.677, 0.704, 9.0%; Asn, His, Ala, 0.677, 0.638, 0.2%; Asn, Cit, Tyr, 0.676, 0.720, 5.1%; Gln, Cit, Tyr, 0.676, 0.714, 5.5%; Gln, Tyr, Met, 0.676, 0.712, 5.3%; Gln, Tyr, Trp, 0.676, 0.709, 5.3%; His, Thr, Tyr, 0.676, 0.700, 5.7%; Gln, Arg, Tyr, 0.676, 0.715, 6.1%; Asn, His, Trp, 0.676, 0.639, 0.2%; Gln, Arg, Met, 0.676, 0.661, 1.3%; Gln, Thr, Tyr, 0.675, 0.713, 6.1%; Thr, Ala, Val, 0.675, 0.668, 2.8%; Asn, Arg, Lys, 0.674, 0.595, 3.3%; Gln, Tyr, Phe, 0.674, 0.710, 5.0%; His, Arg, Lys, 0.673, 0.629, 0.2%; Ser, Gln, Tyr, 0.673, 0.717, 5.9%; Asn, Gln, Met, 0.672, 0.658, 2.4%; Asn, Met, Lys, 0.672, 0.599, 2.4%; Gln, Cit, Met, 0.672, 0.660, 1.1%; Asn, Gly, Lys, 0.671, 0.605, 2.4%; Asn, Orn, Lys, 0.671, 0.574, 3.3%; Asn, Tyr, Orn, 0.671, 0.701, 12.1%; Asn, Arg, Tyr, 0.670, 0.713, 6.4%; Gly, His, Tyr, 0.670, 0.685, 0.6%; Asn, Gly, Tyr, 0.670, 0.710, 11.0%; Asn, Pro, Lys, 0.669, 0.598, 4.0%; Asn, Thr, Lys, 0.669, 0.593, 3.7%; Ser, Asn, Tyr, 0.669, 0.722, 9.2%; Asn, Tyr, Met, 0.669, 0.712, 8.6%; Asn, Tyr, Phe, 0.669, 0.711, 8.5%; Asn, Thr, Tyr, 0.666, 0.714, 12.3%; His, Lys, Trp, 0.666, 0.623, 1.1%; His, Met, Lys, 0.666, 0.615, 0.9%; Ser, His, Tyr, 0.666, 0.709, 3.1%; Gln, Met, Orn, 0.665, 0.634, 3.7%; His, Arg, Orn, 0.665, 0.606, 1.3%; His, Tyr, Lys, 0.665, 0.669, 2.2%; Cit, Arg, Lys, 0.665, 0.601, 3.1%; Tyr, Met, Lys, 0.665, 0.682, 8.5%; Arg, Pro, Tyr, 0.664, 0.692, 4.0%; Arg, Tyr, Orn, 0.664, 0.683, 4.2%; His, Tyr, Orn, 0.664, 0.673, 1.5%; Ser, Asn, Lys, 0.664, 0.606, 3.5%; Asn, Lys, Phe, 0.663, 0.604, 4.2%; Gln, Pro, Orn, 0.663, 0.616, 8.8%; Arg, Lys, Trp, 0.663, 0.617, 0.7%; Gln, Ala, Pro, 0.663, 0.627, 2.8%; Gln, Pro, Trp, 0.663, 0.649, 1.7%; His, Tyr, Phe, 0.663, 0.679, 1.7%; His, Tyr, Trp, 0.663, 0.674, 0.4%; Cit, Tyr, Orn, 0.662, 0.666, 4.8%; Gly, Arg, Tyr, 0.662, 0.702, 2.0%; His, Pro, Lys, 0.662, 0.621, 2.9%; Ala, Arg, Lys, 0.660, 0.605, 3.1%; Asn, His, Pro, 0.660, 0.632, 2.0%; Thr, Arg, Lys, 0.660, 0.603, 2.2%; Cit, Arg, Tyr, 0.658, 0.704, 2.9%; Asn, Cit, Lys, 0.658, 0.591, 2.4%; His, Ala, Arg, 0.658, 0.633, 0.2%; His, Ala, Phe, 0.658, 0.622, 0.6%; His, Thr, Lys, 0.658, 0.613, 1.8%; Cit, Tyr, Trp, 0.657, 0.694, 2.4%; Gln, Ala, Trp, 0.657, 0.634, 1.3%; Ser, His, Lys, 0.657, 0.652, 0.9%; Arg, Lys, Phe, 0.657, 0.610, 2.6%; Asn, Ala, Lys, 0.657, 0.586, 2.9%; Arg, Tyr, Trp, 0.656, 0.693, 1.7%; Cit, Tyr, Lys, 0.656, 0.673, 3.5%; Gly, His, Lys, 0.656, 0.623, 1.3%; His, Cit, Pro, 0.656, 0.634, 0.2%; His, Lys, Phe, 0.656, 0.615, 0.6%; His, Ala, Pro, 0.655, 0.631, 1.8%; His, Ala, Tyr, 0.655, 0.666, 2.6%; His, Arg, Pro, 0.655, 0.635, 0.6%; His, Thr, Cit, 0.655, 0.626, 0.2%; Pro, Lys, Trp, 0.655, 0.614, 3.7%; Pro, Tyr, Met, 0.655, 0.690, 19.1%; Asn, Ala, Met, 0.655, 0.620, 1.8%; His, Arg, Trp, 0.655, 0.642, 0.0%; Ser, His, Orn, 0.655, 0.634, 2.4%; Asn, His, Phe, 0.654, 0.622, 0.6%; Cit, Pro, Tyr, 0.654, 0.682, 4.8%; Gly, His, Phe, 0.654, 0.633, 0.4%; His, Met, Phe, 0.654, 0.626, 0.9%; Ser, His, Ala, 0.654, 0.647, 0.9%; Ala, Arg, Tyr, 0.653, 0.687, 3.3%; Cit, Pro, Lys, 0.653, 0.606, 2.0%; Gln, Ala, Phe, 0.653, 0.625, 1.8%; His, Cit, Lys, 0.653, 0.620, 0.6%; His, Thr, Pro, 0.653, 0.633, 1.8%; Ser, His, Thr, 0.653, 0.646, 0.4%; Thr, Tyr, Lys, 0.653, 0.670, 14.5%; Arg, Met, Lys, 0.653, 0.607, 2.2%; Gln, Met, Trp, 0.652, 0.651, 1.1%; His, Cit, Met, 0.652, 0.629, 0.0%; His, Cit, Trp, 0.652, 0.633, 0.2%; Gln, Ala, Cit, 0.651, 0.614, 1.5%; Gln, Thr, Ala, 0.651, 0.617, 1.5%; Arg, Tyr, Met, 0.651, 0.699, 2.9%; His, Orn, Lys, 0.651, 0.599, 1.3%; His, Thr, Phe, 0.651, 0.629, 0.7%; Asn, Ala, Trp, 0.650, 0.625, 0.6%; Asn, His, Cit, 0.650, 0.619, 0.6%; Asn, His, Met, 0.650, 0.625, 0.7%; His, Pro, Orn, 0.650, 0.613, 2.9%; His, Pro, Tyr, 0.650, 0.663, 4.4%; Ser, His, Pro, 0.650, 0.645, 0.7% [7. Three-variable formula containing amino acids]
Gln, His, Ile, 0.752, 0.709, 1.1%; Gln, Lys, Ile, 0.745, 0.683, 0.9%; Asn, Lys, Ile, 0.744, 0.672, 2.6%; Cit, Tyr, Ile, 0.741, 0.717, 4.0 Gln, Leu, Phe, 0.741, 0.678, 0.0%; Gln, Cit, Ile, 0.740, 0.698, 0.4%; Gln, Lys, Leu, 0.740, 0.681, 0.2%; Gln, Tyr, Leu, 0.740, 0.720 Asn, Gln, Ile, 0.739, 0.693, 0.9%; Gln, Ile, Phe, 0.739, 0.688, 0.9%; Gln, Tyr, Ile, 0.738, 0.724, 5.3%; Asn, Gln, Leu, 0.737 , 0.690, 0.2%; Asn, His, Ile, 0.737, 0.696, 1.1%; Gln, Ile, Leu, 0.736, 0.696, 0.2%; Gln, Orn, Leu, 0.736, 0.674, 0.2%; , 0.735, 0.674, 2.0%; Arg, Tyr, Lys, 0.735, 0.699, 4.4%; Gln, His, Tyr, 0.735, 0.727, 0.9%; Tyr, Met, Ile, 0.735, 0.719, 6.2%; , Leu, 0.733, 0.671, 0.6%; Asn, Tyr, Leu, 0.733, 0.718, 2.8%; Gln, Pro, Ile, 0.733, 0.693, 1.1%; Asn, Val, Lys, 0.732, 0.677, 1.5%; , Ile, Phe, 0.732, 0.708, 6.8%; Gln, Ile, Trp, 0.731, 0.690, 0.9%; Gln, Val, Ile, 0.731, 0.697, 0.6%; Gln, Arg, Ile, 0.731, 0.692, 0.7% His, Ile, Phe, 0.730, 0.676, 0.9%; Tyr, Leu, Phe, 0.730 , 0.705, 2.0%; Gly, Gln, Ile, 0.730, 0.678, 0.9%; Asn, Tyr, Ile, 0.730, 0.716, 8.6%; Gln, Orn, Ile, 0.730, 0.682, 1.5%; Gln, Ala, Leu, 0.729, 0.680, 0.2%; Asn, Cit, Ile, 0.728, 0.691, 0.4%; Asn, Gly, Leu, 0.728, 0.675, 0.4%; Gln, Ala , Ile, 0.728, 0.687, 1.5%; Gln, Val, Lys, 0.727, 0.682, 0.6%; Gly, Gln, Leu, 0.727, 0.677, 0.2%; Asn, Leu, Phe, 0.726, 0.673, 0.4%; , Thr, Ile, 0.726, 0.682, 1.5%; Ser, Gln, Ile, 0.726, 0.661, 2.6%; Ser, Gln, Leu, 0.726, 0.669, 0.2%; Arg, Tyr, Ile, 0.726, 0.715, 5.5% Asn, Tyr, Val, 0.726, 0.722, 7.4%; Asn, His, Val, 0.725, 0.693, 0.2%; Gln, Met, Ile, 0.725, 0.689, 1.3%; His, Tyr, Ile, 0.724, 0.701, Gln, His, Lys, 0.724, 0.671, 1.5%; Gln, Leu, Trp, 0.724, 0.687, 0.0%; Ile, Leu, Phe, 0.724, 0.673, 0.6%; Gln, His, Pro, 0.723, Gln, Pro, Leu, 0.723, 0.688, 0.2%; Gln, Tyr, Val, 0.723, 0.720, 6.6%; Cit, Ile, Phe, 0.723, 0.681, 0.7%; 0.723, 0.682, 0.2%; Gln, Arg, Leu, 0.722, 0.681, 0.2%; Tyr, Met, Leu, 0.722, 0.711, 4.2%; Asn, Ile, Trp, 0.721, 0.682, 1.5%; Asn, Thr, Ile, 0.721, 0.679, 2.2%; Cit, Lys, Ile, 0.721, 0.674, 1.7%; Gln, His, Leu, 0.721, 0.694, 0.4%; Met, Lys, Ile, 0.721, 0.666, 2.6%; Tyr, Ile, Trp, 0.721, 0.706, 9.4%; Val, Ile, Phe, 0.721, 0.681, 1.3 %; Asn, Ala, Ile, 0.721, 0.681, 2.0%; Asn, Ile, Phe, 0.721, 0.675, 1.5%; Asn, Orn, Leu, 0.721, 0.668, 0.7%; Ala, Tyr, Ile, 0.720, 0.706 Arg, Tyr, Leu, 0.720, 0.705, 2.2%; Asn, Met, Leu, 0.720, 0.680, 0.6%; Gln, Cit, Leu, 0.720, 0.678, 0.2%; Tyr, Orn, Ile, 0.720 , 0.716, 7.5%; Asn, Leu, Trp, 0.719, 0.678, 0.4%; Cit, Arg, Ile, 0.719, 0.686, 0.9%; Cit, Met, Ile, 0.719, 0.690, 1.8%; Gln, Met, Leu, 0.719, 0.684, 0.2%; Gly, Tyr, Ile, 0.719, 0.700, 7.7%; Ser, Asn, Leu, 0.719, 0.662, 0.6%; Thr, Tyr Pro, Tyr, Ile, 0.719, 0.706, 7.0%; Ala, Cit, Ile, 0.718, 0.686, 3.3%; Arg, Val, Lys, 0.718, 0.669, 1.7%; Asn , Thr, Leu, 0.718, 0.674, 0.6%; Cit, Pro, Ile, 0.718, 0.6%; 687, 1.8%; Lys, Ile, Phe, 0.718, 0.661, 1.3%; Arg, Ile, Leu, 0.717, 0.680, 0.9%; Asn, His, Leu, 0.717, 0.682, 0.2%; Asn, Val, Leu, 0.717, 0.680, 0.6%; Asn, Gly, Ile, 0.717, 0.676, 2.6%; Asn, Orn, Ile, 0.717, 0.675, 2.9%; Gln, His, Val, 0.717, 0.698, 0.2%; Gln, Val, Leu, 0.717, 0.685, 0.2%; His, Arg, Ile, 0.717, 0.683, 0.9%; His, Met, Ile, 0.717, 0.678, 1.7%; Val, Ile, 0.717, 0.706, 6.1%; Ala, Ile, Phe, 0.716, 0.666, 2.2%; Asn, Val, Ile, 0.716, 0.686, 1.3%; Ser, Asn, Ile, 0.716, 0.652, 3.1%; Tyr, Val, Met, 0.716, 0.720, 7.9%; Gly, Cit, Ile, 0.716, 0.681, 1.3%; His, Tyr, Val, 0.716, 0.707, 4.6%; Lys, Leu, Phe, 0.716, 0.656, 0.4 %; Thr, Cit, Ile, 0.716, 0.683, 1.5%; Asn, Ala, Leu, 0.715, 0.673, 0.6%; Asn, Arg, Ile, 0.715, 0.683, 2.9%; Asn, Arg, Leu, 0.715, 0.677 Asn, Cit, Leu, 0.715, 0.675, 0.4%; Cit, Ile, Trp, 0.715, 0.691, 0.9%; Cit, Orn, Ile, 0.715, 0.668, 1.7%; His, Leu, Phe, 0.715 , 0.664, 0.0%; Thr, Ile, Phe, 0.715, 0.668, 2.2%; Thr, Leu, Phe, 0.715, 0.660, 0.4%; Tyr, Lys, Ile, 0.715, 0.692, 7.7%; Ala, Met, Ile, 0.714, 0.675, 3.5%; Arg, Lys, Leu, 0.714, 0.660, 0.4%; Val, Ile, 0.714, 0.686, 2.8%; Cit, Val, Ile, 0.714, 0.688, 0.7%; Gly, Cit, Leu, 0.714, 0.661, 0.4%; Gly, His, Ile, 0.714, 0.677, 2.4%; Gly, Ile, Phe, 0.714, 0.669, 2.2%; Orn, Ile, Phe, 0.714, 0.671, 2.2%; Pro, Ile, Phe, 0.714, 0.666, 1.8%; Val, Leu, Phe, 0.714, 0.667, 0.6 Ala, Arg, Ile, 0.714, 0.678, 2.4%; Arg, Leu, Phe, 0.714, 0.665, 0.2%; Asn, Met, Ile, 0.714, 0.680, 2.2%; Cit, Tyr, Leu, 0.714, 0.697 Cit, Val, Leu, 0.714, 0.671, 0.6%; Gly, Leu, Phe, 0.714, 0.658, 0.4%; Lys, Ile, Leu, 0.714, 0.667, 2.0%; Arg, Ile, Phe, 0.713 , 0.674, 2.0%; Asn, Pro, Ile, 0.713, 0.679, 2.6%; Cit, Ile, Leu, 0.713, 0.679, 0.6%; Gly, Tyr, Val, 0.713, 0.706, 5.9%; , 0.713, 0.681, 1.5%; His, Lys, Ile, 0.713, 0.670, 3.9%; His, Pro, Ile, 0.713, 0.676, 2.4%; Val, Lys, Ile, 0.713, 0.671, 3.1%; , Ile, 0.712, 0.678, 2.6%; His, Ile, Leu, 0.712, 0.678, His, Orn, Ile, 0.712, 0.677, 2.4%; Ile, Leu, Trp, 0.712, 0.676, 1.3%; Ser, Tyr, Ile, 0.712, 0.698, 7.0%; Ala, Leu, Trp, 0.712, Ala, Met, Leu, 0.712, 0.669, 0.9%; Arg, Tyr, Val, 0.712, 0.717, 4.6%; His, Ile, Trp, 0.712, 0.679, 2.9%; Met, Ile, Phe, Ser, His, Ile, 0.712, 0.666, 3.5%; Tyr, Ile, Leu, 0.712, 0.695, 5.0%; Gln, His, Ala, 0.711, 0.679, 1.1%; Leu, 0.711, 0.691, 3.9%; Pro, Tyr, Val, 0.711, 0.709, 6.1%; Ser, Cit, Ile, 0.711, 0.663, 2.6%; Tyr, Val, Phe, 0.711, 0.710, 6.1%; Leu, Trp, 0.711, 0.670, 0.9%; Gln, His, Orn, 0.710, 0.665, 0.9%; Gly, Lys, Ile, 0.710, 0.665, 4.4%; Leu, Phe, Trp, 0.710, 0.660, 0.4%; Lys, Ile, Trp, 0.710, 0.662, 4.4%; Lys, Leu, Trp, 0.710, 0.660, 0.9%; Pro, Leu, Phe, 0.710, 0.665, 0.7%; Ser, Leu, Phe, 0.710, 0.654, 0.6 Ala, Ile, Leu, 0.710, 0.673, 3.5%; Ala, Tyr, Val, 0.710, 0.708, 6.1%; Met, Lys, Leu, 0.710, 0.658, 0.7%; Pro, Met, Ile, 0.710, 0.678 Thr, Lys, Ile, 0.710, 0.665, 3.7%; Ala, Leu, Phe, 0.709, 0.662, 0.2%; Gln, His, Met, 0.709, 0.679, 0.7%; Met, Ile, Leu, 0.709, 0.675, 1.1%; Met, Leu, Phe, 0.709, 0.659, 0.4%; Leu, 0.709, 0.673, 1.3%; Tyr, Leu, Trp, 0.709, 0.701, 4.4%; Tyr, Lys, Leu, 0.709, 0.690, 4.0%; Ala, Orn, Ile, 0.709, 0.683, 3.9%; Tyr, Leu, 0.709, 0.689, 3.1%; Arg, Orn, Ile, 0.709, 0.666, 3.3%; Arg, Pro, Ile, 0.709, 0.682, 3.3%; Gly, Lys, Leu, 0.709, 0.655, 0.6%; Gly, Val, Leu, 0.709, 0.669, 0.7%; His, Thr, Ile, 0.709, 0.677, 2.9%; His, Val, Ile, 0.709, 0.681, 2.4%; Ser, Ile, Phe, 0.709, 0.646, 2.8 %; Tyr, Val, Trp, 0.709, 0.712, 8.5%; Val, Lys, Leu, 0.709, 0.665, 0.7%; Val, Lys, Phe, 0.709, 0.668, 1.1%; Ala, Lys, Ile, 0.708, 0.663 , 5.5%; Arg, Orn, Leu, 0.708, 0.651, 1.1%; Gly, Arg, Ile, 0.708, 0.672, 3.1%; Gly, Ile, Leu, 0.708, 0.669, 1.1%; , 0.674, 2.6%; His, Cit, Val, 0.708, 0.679, 1.1%; His, Leu, Trp, 0.708, 0.665, 0.7%; His, Val, Lys, 0.708, 0.669, 2.0%; , 0.708, 0.680, 0.6%; Orn, Leu, Phe, 0.708, 0.653, 0.6%; Orn, Lys, Ile, 0.708, 0.673, 3.3%; Pro, Lys, Ile, 0.708, 0.664, 5.5%; Pro, Tyr, Leu, 0.708, 0.692, 3.9%; Ser, Leu, Trp, 0.708, 0.654, 0.6 %; Tyr, Val, Leu, 0.708, 0.699, 4.6%; Arg, Pro, Leu, 0.707, 0.671, 0.9%; Cit, Leu, Trp, 0.707, 0.666, 0.6%; His, Ala, Leu, 0.707, 0.664, 0.4%; His, Lys, Leu, 0.707, 0.657, 0.6%; Met, Orn, Ile, 0.707, 0.678, 2.4%; Thr, Ala, Leu, 0.707 Thr, Cit, Leu, 0.707, 0.665, 0.4%; Thr, Tyr, Val, 0.707, 0.715, 11.2%; Tyr, Val, Lys, 0.707, 0.699, 5.9%; Ala, Arg, Leu Arg, Ile, Trp, 0.707, 0.682, 2.8%; Arg, Met, Ile, 0.707, 0.679, 2.4%; Cit, Lys, Leu, 0.707, 0.655, 0.6%; Gly, Ile Ile, Phe, Trp, 0.707, 0.668, 2.4%; Orn, Lys, Leu, 0.707, 0.648, 0.6%; Ser Thr, Ala, Ile, 0.707, 0.676, 3.9%; Thr, Ile, Leu, 0.707, 0.674, 1.3%; Tyr, Val, Orn, 0.707, 0.710, 6.1% Val, Orn, Leu, 0.707, 0.661, 1.1%; Ala, Cit, Leu, 0.7 Orn, Ile, Trp, 0.706, 0.679, 2.8%; Ser, Lys, 06, 0.666, 0.7%; Gly, Arg, Leu, 0.706, 0.662, 0.4%; Leu, 0.706, 0.652, 0.6%; Ala, Val, Ile, 0.705, 0.681, 4.2%; Gly, Ala, Ile, 0.705, 0.675, 4.2%; Gly, Leu, Trp, 0.705, 0.662, 0.6%; Orn, Leu, 0.705, 0.651, 0.9%; Gly, Pro, Ile, 0.705, 0.675, 3.7%; His, Cit, Leu, 0.705, 0.667, 0.2%; Pro, Met, Leu, 0.705, 0.669, 0.9%; Ser, Ile, Leu, 0.705, 0.650, 2.2%; Val, Ile, Leu, 0.705, 0.676, 1.3%; Val, Ile, Trp, 0.705, 0.682, 1.8%; Cit, Leu, Phe, 0.705, 0.657, 0.2 %; Cit, Met, Leu, 0.705, 0.664, 0.4%; Cit, Val, Lys, 0.705, 0.668, 1.7%; Gly, Thr, Ile, 0.705, 0.673, 2.6%; His, Val, Orn, 0.705, 0.673 Orn, Leu, Trp, 0.705, 0.651, 1.3%; Ser, Ala, Leu, 0.705, 0.658, 0.6%; Ser, Cit, Leu, 0.705, 0.655, 0.4%; Ser, Lys, Ile, 0.705 Ser, Tyr, Val, 0.705, 0.714, 5.9%; Thr, Leu, Trp, 0.705, 0.663, 0.6%; Thr, Orn, Ile, 0.705, 0.679, 2.6%; Val, Met, Ile , 0.705, 0.682, 2.0%; Val, Met, Lys, 0.705, 0.669, 2.0%; , Ile, Trp, 0.704, 0.675, 4.2%; Ala, Pro, Ile, 0.704, 0.675, 4.0%; Arg, Pro, Lys, 0.704, 0.631, 6.1%; Gln, His, Thr, 0.704, 0.676, 0.7% Gly, Ala, Leu, 0.704, 0.662, 0.6%; Gly, Met, Leu, 0.704, 0.658, 0.7%; Met, Orn, Leu, 0.704, 0.652, 0.7%; Orn, Ile, Leu, 0.704, 0.669, Pro, Ile, Trp, 0.704, 0.675, 3.9%; Pro, Orn, Ile, 0.704, 0.680, 2.8%; Ser, Met, Ile, 0.704, 0.646, 3.7%; Thr, Ile, Trp, 0.704, 0.677, 2.8%; Thr, Met, Ile, 0.704, 0.673, 2.9%; Thr, Val, Ile, 0.704, 0.680, 2.0%; Val, Lys, Trp, 0.704, 0.670, 2.4%; Val, Met, Leu, 0.704, 0.669, 0.7%; Gly, His, Leu, 0.703, 0.661, 0.2%; Gly, Thr, Leu, 0.703, 0.661, 0.7%; His, Val, Met, 0.703, 0.682, 1.5%; Trp, 0.703, 0.668, 1.3%; Ser, Gly, Leu, 0.703, 0.654, 0.6%; Ser, Orn, Leu, 0.703, 0.649, 0.9%; Thr, Arg, Ile, 0.703, 0.675, 3.1%; Met, Leu, 0.703, 0.661, 0.4%; Thr, Tyr, Leu, 0.703, 0.697, 6.4%; Thr, Val, Lys, 0.703, 0.668, 1.8%; Ala, Val, Leu, 0.703, 0.666, 0.6%; Gly, Pro, Leu, 0.703, 0.662, 1.1%; Gly, Val, Ile, 0.703, 0 .678, 1.8%; Met, Leu, Trp, 0.703, 0.663, 0.6%; Pro, Val, Leu, 0.703, 0.671, 1.3%; Ser, Ala, Ile, 0.703, 0.653, 4.8%; , 0.703, 0.657, 0.7%; Thr, Pro, Ile, 0.703, 0.676, 2.9%; Thr, Val, Leu, 0.703, 0.670, 0.7%; Asn, His, Tyr, 0.70

2, 0.708, 2.6%; Cit, Arg, Leu, 0.702, 0.664, 0.4%; His, Met, Leu, 0.702, 0.666, 0.2%; His, Tyr, Leu, 0.702, 0.691, 3.7%; Lys, 0.702, 0.670, 2.4%; Tyr, Orn, Leu, 0.702, 0.693, 3.7%; Val, Orn, Ile, 0.702, 0.680, 2.0%; Ala, Lys, Leu, 0.702, 0.658, 0.6%; Val, Leu, 0.702, 0.669, 0.6%; Gln, Ala, Lys, 0.702, 0.635, 3.5%; Gln, His, Cit, 0.702, 0.675, 0.9%; His, Ala, Val, 0.702, 0.675, 2.2%; His, Val, Trp, 0.702, 0.678, 1.3%; Pro, Val, Ile, 0.702, 0.680, 2.8%; Ala, Orn, Leu, 0.701, 0.659, 0.6%; Asn, His, Lys, 0.701, 0.629, 1.7 %; Gln, Tyr, Lys, 0.701, 0.710, 5.9%; Gly, Val, Lys, 0.701, 0.669, 2.4%; His, Orn, Leu, 0.701, 0.653, 0.4%; Ser, Ile, Trp, 0.701, 0.651 Ser, Val, Ile, 0.701, 0.660, 4.0%; Val, Orn, Lys, 0.701, 0.667, 2.4%; Cit, Pro, Leu, 0.700, 0.669, 0.6%; Gln, His, Arg, 0.700 , 0.675, 0.9%; Gln, Pro, Tyr, 0.700, 0.723, 5.9%; Gly, Gln, His, 0.700, 0.674, 0.9%; His, Arg, Val, 0.700, 0.681, 0.6%; , 0.700, 0.652, 0.6%; Ser, Met, Leu, 0.700, 0.651, 0.6%; Leu, Trp, 0.700, 0.666, 0.4%; Asn, Gln, Val, 0.700, 0.684, 0.6%; Cit, Orn, Leu, 0.700, 0.649, 0.9%; Ser, Arg, Ile, 0.700, 0.646, 2.6%; Ser, Gln, His, 0.700, 0.677, 0.9%; Asn, Val, Orn, 0.699, 0.673, 2.4%; Gln, His, Phe, 0.699, 0.674, 0.9%; Gln, Met, Lys, 0.699, 0.652, 2.4 %; Gln, Pro, Lys, 0.699, 0.645, 3.9%; Gln, Val, Met, 0.699, 0.686, 0.7%; His, Arg, Leu, 0.699, 0.666, 0.2%; His, Pro, Leu, 0.699, 0.665 Pro, Lys, Leu, 0.699, 0.657, 1.7%; Pro, Orn, Leu, 0.699, 0.660, 1.5%; Ser, Gly, Ile, 0.699, 0.652, 4.2%; Ser, Thr, Ile, 0.699 Thr, Pro, Leu, 0.699, 0.667, 1.5%; Gln, Val, Orn, 0.698, 0.674, 0.7%; Ser, His, Val, 0.698, 0.681, 1.3%; Ser, Tyr, Leu Asn, Tyr, Lys, 0.698, 0.695, 8.8%; Asn, Val, Met, 0.698, 0.678, 1.5%; Gln, Cit, Val, 0.698, 0.683, 0.6%; Gly, Gln, Val, 0.698, 0.682, 0.6%; His, Pro, Val, 0.698, 0.676, 1.3%; Ser, Pro, Ile, 0.698, 0.651, 5.0%; , Pro, Leu, 0.697, 0.661, 0.7%; Arg, Pro, Val, 0.697, 0.7%; 680, 2.2%; Pro, Val, Phe, 0.697, 0.677, 1.3%; Ser, His, Leu, 0.697, 0.660, 0.4%; Ser, Pro, Leu, 0.697, 0.658, 1.1%; Asn, Gln, Lys, 0.697, 0.626, 2.2%; Asn, Val, Phe, 0.697, 0.679, 1.8%; Cit, Pro, Val, 0.697, 0.675, 1.3%; Gln, Thr, Val, 0.697, 0.682, 0.6%; Ser, Asn, Val, 0.697, 0.672, 1.3%; Ser, Orn, Ile, 0.697, 0.658, 4.4%; Thr, Orn, Leu, 0.697, 0.650, 1.1%; Cit, Val, 0.696, 0.675, 1.7%; Asn, Pro, Val, 0.696, 0.679, 1.7%; Gln, Arg, Val, 0.696, 0.683, 0.6%; Gln, Pro, Met, 0.696, 0.664, 1.7%; Gly, Gln, Lys, 0.696, 0.634, 2.2%; Pro, Val, Lys, 0.696, 0.664, 2.8%; Ser, Gln, Val, 0.696, 0.673, 0.6%; Asn, Arg, Val, 0.695, 0.679, 2.0 %; Gln, Pro, Val, 0.695, 0.686, 0.9%; Ser, Thr, Leu, 0.695, 0.651, 0.6%; Gln, Orn, Lys, 0.695, 0.619, 2.0%; , 0.4%; Gly, His, Val, 0.695, 0.676, 1.3%; His, Thr, Leu, 0.694, 0.660, 0.2%; Arg, Val, Phe, 0.693, 0.677, 2.4%; , 0.675, 1.1%; Gln, Cit, Pro, 0.693, 0.649, 2.4%; Arg, Met, Leu, 0.693, 0.663, 0.4%; Asn, Ala, Val, 0.693, 0.675, 2.2%; Asn, Gly, Val, 0.693, 0.676, 1.7%; Gln, Cit, Lys, 0.693, 0.633, 1.7%; Thr, Val, 0.693, 0.678, 1.7%; Asn, Tyr, Trp, 0.692, 0.705, 5.5%; Gln, Lys, Phe, 0.692, 0.637, 2.0%; Gly, Arg, Val, 0.692, 0.675, 2.2%; Gly, Cit, Val, 0.692, 0.671, 1.1%; Ser, Gln, Lys, 0.692, 0.639, 2.2%; Asn, Thr, Val, 0.691, 0.675, 1.7%; Asn, Val, Trp, 0.691, 0.675, 0.9 %; Cit, Arg, Val, 0.691, 0.676, 1.8%; Val, Orn, Phe, 0.691, 0.667, 1.7%; Ala, Val, Lys, 0.691, 0.664, 2.6%; Asn, Gln, His, 0.691, 0.672 Cit, Val, Orn, 0.691, 0.657, 1.8%; Gln, Ala, Val, 0.691, 0.674, 1.7%; Gln, His, Trp, 0.691, 0.674, 0.6%; Thr, Val, Orn, 0.691 , 0.667, 2.9%; Gln, Lys, Trp, 0.690, 0.648, 1.3%; Gln, Arg, Pro, 0.690, 0.650, 5.9%; Gln, Thr, Lys, 0.690, 0.634, 1.8%; Ala, Val, Phe, 0.688, 0.669, 1.8%; Gly, Gln, Pro, 0.688, 0.654, 5.0%; Gly, Val, Phe, 0.688, 0.675, 1.5%; His, Arg , Tyr, 0.688, 0.694, 0.6%; Val, Orn, Trp, 0.688, 0.667, Ala, Cit, Val, 0.688, 0.669, 1.5%; Cit, Val, Met, 0.688, 0.672, 1.8%; Cit, Val, Trp, 0.688, 0.672, 1.1%; Ser, Cit, Val, 0.688, Thr, Val, Phe, 0.688, 0.675, 1.5%; Asn, Gln, Pro, 0.687, 0.651, 4.6%; Gly, Val, Orn, 0.687, 0.668, 2.9%; Ser, Pro, Val, Ser, Val, Orn, 0.687, 0.663, 2.8%; Ala, Arg, Val, 0.686, 0.672, 2.4%; Arg, Val, Orn, 0.686, 0.662, 3.1%; Val, 0.686, 0.675, 2.8%; Pro, Val, Met, 0.686, 0.675, 2.9%; Pro, Val, Orn, 0.686, 0.668, 3.3%; Thr, Cit, Val, 0.686, 0.669, 0.9%; Met, Orn, 0.686, 0.665, 2.9%; Arg, Val, Met, 0.686, 0.674, 1.8%; Gly, Gln, Met, 0.686, 0.661, 1.8%; Ser, Arg, Val, 0.686, 0.666, 1.8%; Arg, Val, Trp, 0.685, 0.673, 1.7%; Gln, Thr, Met, 0.685, 0.654, 1.3%; Gln, Thr, Pro, 0.685, 0.639, 3.1%; Gly, Val, Met, 0.685, 0.672, 2.8 %; Val, Met, Trp, 0.685, 0.673, 2.8%; Ser, Gln, Pro, 0.684, 0.629, 6.4%; Thr, Arg, Val, 0.684, 0.670, 2.4%; Ala, Val, Orn, 0.683, 0.667 , 2.8%; Asn, His, Orn, 0.683, 0.616, 0.9%; Gln, Ala, Met, Gln, Met, Phe, 0.683, 0.657, 1.8%; Gln, Pro, Phe, 0.683, 0.662, 5.3%; Gly, Val, Trp, 0.683, 0.670, 2.2%; Ser, Gln, Met, 0.683, 0.658, 1.8%; Thr, Pro, Val, 0.683, 0.675, 3.1%; Asn, Lys, Trp, 0.683, 0.621, 1.5%; Gln, Tyr, Orn, 0.683, 0.701, 5.0%; Ala, Val, 0.683, 0.666, 2.6%; Ser, Thr, Val, 0.683, 0.666, 1.7%; Val, Met, Phe, 0.683, 0.671, 2.0%; Ser, Val, Phe, 0.683, 0.671, 0.9%; Arg, Orn, Lys, 0.682, 0.588, 4.4%; Gly, Ala, Val, 0.682, 0.671, 2.6%; Asn, Pro, Tyr, 0.681, 0.703, 11.4%; Gly, Thr, Val, 0.681, 0.671, 2.0 Ala, Val, Trp, 0.681, 0.670, 2.6%; Asn, Gln, Tyr, 0.681, 0.718, 6.8%; Ala, Val, Met, 0.680, 0.671, 2.6%; His, Cit, Tyr, 0.680, 0.692 , 0.4%; Pro, Val, Trp, 0.680, 0.673, 3.1%; Ser, Val, Met, 0.680, 0.666, 2.6%; Thr, Val, Trp, 0.680, 0.669, 1.5%; Gln, Ala, Tyr, 0.679, 0.709, 7.0%; Gly, Gln, Tyr, 0.679, 0.710, 7.0%; His, Tyr, Met, 0.678, 0.702, 2.8%; Ser, Gly, Val , 0.678, 0.665, 2.0%; Thr, Val, Met, 0.678, 0.670, 2.4% Ser, Val, Trp, 0.677, 0.665, 2.2%; Asn, Ala, Tyr, 0.677, 0.704, 9.0%; Asn, His, Ala, 0.677, 0.638, Asn, Cit, Tyr, 0.676, 0.720, 5.1%; Gln, Cit, Tyr, 0.676, 0.714, 5.5%; Gln, Tyr, Met, 0.676, 0.712, 5.3%; Gln, Tyr, Trp, 0.676, His, Thr, Tyr, 0.676, 0.700, 5.7%; Gln, Arg, Tyr, 0.676, 0.715, 6.1%; Asn, His, Trp, 0.676, 0.639, 0.2%; Gln, Arg, Met, 0.676, 0.661, 1.3%; Gln, Thr, Tyr, 0.675, 0.713, 6.1%; Thr, Ala, Val, 0.675, 0.668, 2.8%; Asn, Arg, Lys, 0.674, 0.595, 3.3%; Phe, 0.674, 0.710, 5.0%; His, Arg, Lys, 0.673, 0.629, 0.2%; Ser, Gln, Tyr, 0.673, 0.717, 5.9%; Asn, Gln, Met, 0.672, 0.658, 2.4%; Met, Lys, 0.672, 0.599, 2.4%; Gln, Cit, Met, 0.672, 0.660, 1.1%; Asn, Gly, Lys, 0.671, 0.605, 2.4%; Asn, Orn, Lys, 0.671, 0.574, 3.3%; Asn, Tyr, Orn, 0.671, 0.701, 12.1%; Asn, Arg, Tyr, 0.670, 0.713, 6.4%; Gly, His, Tyr, 0.670, 0.685, 0.6%; Asn, Gly, Tyr, 0.670, 0.710, 11.0 %; Asn, Pro, Lys, 0.669, 0.598, 4.0%; Asn, Thr, Lys, 0 Ser, Asn, Tyr, 0.669, 0.722, 9.2%; Asn, Tyr, Met, 0.669, 0.712, 8.6%; Asn, Tyr, Phe, 0.669, 0.711, 8.5%; Asn, Thr , Tyr, 0.666, 0.714, 12.3%; His, Lys, Trp, 0.666, 0.623, 1.1%; His, Met, Lys, 0.666, 0.615, 0.9%; Ser, His, Tyr, 0.666, 0.709, 3.1%; , Met, Orn, 0.665, 0.634, 3.7%; His, Arg, Orn, 0.665, 0.606, 1.3%; His, Tyr, Lys, 0.665, 0.669, 2.2%; Cit, Arg, Lys, 0.665, 0.601, 3.1% Tyr, Met, Lys, 0.665, 0.682, 8.5%; Arg, Pro, Tyr, 0.664, 0.692, 4.0%; Arg, Tyr, Orn, 0.664, 0.683, 4.2%; His, Tyr, Orn, 0.664, 0.673, Ser, Asn, Lys, 0.664, 0.606, 3.5%; Asn, Lys, Phe, 0.663, 0.604, 4.2%; Gln, Pro, Orn, 0.663, 0.616, 8.8%; Arg, Lys, Trp, 0.663, 0.617, 0.7%; Gln, Ala, Pro, 0.663, 0.627, 2.8%; Gln, Pro, Trp, 0.663, 0.649, 1.7%; His, Tyr, Phe, 0.663, 0.679, 1.7%; Cit, Tyr, Orn, 0.662, 0.666, 4.8%; Gly, Arg, Tyr, 0.662, 0.702, 2.0%; His, Pro, Lys, 0.662, 0.621, 2.9%; Lys, 0.660, 0.605, 3.1%; Asn, His, Pro, 0.660, 0.632, 2.0%; Thr, Arg, Lys, 0.660, 0.603, 2.2%; Cit, Arg, Tyr, 0.658, 0.704, 2.9%; Asn, Cit, Lys, 0.658, 0.591, 2.4%; His, Ala, Arg, 0.658, 0.633, 0.2 %; His, Ala, Phe, 0.658, 0.622, 0.6%; His, Thr, Lys, 0.658, 0.613, 1.8%; Cit, Tyr, Trp, 0.657, 0.694, 2.4%; Gln, Ala, Trp, 0.657, 0.634 Ser, His, Lys, 0.657, 0.652, 0.9%; Arg, Lys, Phe, 0.657, 0.610, 2.6%; Asn, Ala, Lys, 0.657, 0.586, 2.9%; Arg, Tyr, Trp, 0.656 , 0.693, 1.7%; Cit, Tyr, Lys, 0.656, 0.673, 3.5%; Gly, His, Lys, 0.656, 0.623, 1.3%; His, Cit, Pro, 0.656, 0.634, 0.2%; His, Ala, Pro, 0.655, 0.631, 1.8%; His, Ala, Tyr, 0.655, 0.666, 2.6%; His, Arg, Pro, 0.655, 0.635, 0.6%; His, Thr Pro, Lys, Trp, 0.655, 0.614, 3.7%; Pro, Tyr, Met, 0.655, 0.690, 19.1%; Asn, Ala, Met, 0.655, 0.620, 1.8%; Ser, His, Orn, 0.655, 0.634, 2.4%; Asn, His, Phe, 0.654, 0.622, 0.6%; Cit, Pro, Tyr, 0.654, 0.682, 4.8%. Gly, His, Phe, 0.654, 0.633, 0.4%; His, Met, Phe, 0.65 4, 0.626, 0.9%; Ser, His, Ala, 0.654, 0.647, 0.9%; Ala, Arg, Tyr, 0.653, 0.687, 3.3%; Cit, Pro, Lys, 0.653, 0.606, 2.0%; Phe, 0.653, 0.625, 1.8%; His, Cit, Lys, 0.653, 0.620, 0.6%; His, Thr, Pro, 0.653, 0.633, 1.8%; Ser, His, Thr, 0.653, 0.646, 0.4%; Tyr, Lys, 0.653, 0.670, 14.5%; Arg, Met, Lys, 0.653, 0.607, 2.2%; Gln, Met, Trp, 0.652, 0.651, 1.1%; His, Cit, Met, 0.652, 0.629, 0.0%; His, Cit, Trp, 0.652, 0.633, 0.2%; Gln, Ala, Cit, 0.651, 0.614, 1.5%; Gln, Thr, Ala, 0.651, 0.617, 1.5%; Arg, Tyr, Met, 0.651, 0.699, 2.9 %; His, Orn, Lys, 0.651, 0.599, 1.3%; His, Thr, Phe, 0.651, 0.629, 0.7%; Asn, Ala, Trp, 0.650, 0.625, 0.6%; Asn, His, Cit, 0.650, 0.619 Asn, His, Met, 0.650, 0.625, 0.7%; His, Pro, Orn, 0.650, 0.613, 2.9%; His, Pro, Tyr, 0.650, 0.663, 4.4%; Ser, His, Pro, 0.650 , 0.645, 0.7%
［８．アミノ酸を含む４変数の式］
Gln, His, Tyr, Ile, 0.765, 0.731, 2.4%, 0.755, 0.773; Gln, His, Ile, Phe, 0.763, 0.707, 0.0%, 0.728, 0.682; Gln, Tyr, Ile, Phe, 0.761, 0.729, 6.2%, 0.740, 0.702; Asn, Gln, His, Ile, 0.760, 0.714, 1.1%, 0.735, 0.716; Gln, His, Cit, Ile, 0.759, 0.712, 0.7%, 0.734, 0.728; Gln, Arg, Lys, Ile, 0.759, 0.687, 1.3%, 0.685, 0.730; Asn, Arg, Lys, Ile, 0.757, 0.674, 2.2%, 0.668, 0.684; His, Tyr, Ile, Phe, 0.755, 0.709, 3.9%, 0.703, 0.680; Gln, His, Met, Ile, 0.754, 0.709, 0.6%, 0.728, 0.718; Asn, Cit, Lys, Ile, 0.753, 0.681, 1.8%, 0.668, 0.682; Gln, His, Arg, Ile, 0.753, 0.709, 0.6%, 0.733, 0.724; Gln, Tyr, Leu, Phe, 0.753, 0.728, 1.8%, 0.729, 0.677; Arg, Tyr, Lys, Ile, 0.752, 0.710, 3.9%, 0.708, 0.742; Asn, Gln, Lys, Ile, 0.752, 0.679, 1.3%, 0.657, 0.679; Gln, His, Val, Ile, 0.752, 0.709, 1.1%, 0.729, 0.730; Gln, His, Ile, Leu, 0.752, 0.709, 0.9%, 0.728, 0.730; Gln, His, Pro, Ile, 0.752, 0.708, 1.1%, 0.728, 0.734; Gln, Tyr, Leu, Trp, 0.752, 0.726, 4.4%, 0.711, 0.710; Gly, Gln, Tyr, Ile, 0.752, 0.720, 4.8%, 0.725, 0.734; Asn, Gln, Lys, Leu, 0.751, 0.679, 0.2%, 0.648, 0.615; Gln, His, Ala, Ile, 0.751, 0.707, 1.1%, 0.728, 0.738; Gly, Gln, Tyr, Leu, 0.751, 0.718, 2.8%, 0.706, 0.706; Gln, His, Ile, Trp, 0.750, 0.708, 1.5%, 0.723, 0.714; Thr, Tyr, Leu, Phe, 0.750, 0.721, 2.0%, 0.716, 0.657; Gly, Gln, Lys, Ile, 0.750, 0.676, 0.7%, 0.650, 0.696; Asn, Thr, Lys, Ile, 0.749, 0.674, 2.4%, 0.647, 0.661; Gln, Cit, Tyr, Ile, 0.749, 0.730, 3.7%, 0.747, 0.759; Gln, Tyr, Ile, Leu, 0.749, 0.724, 3.9%, 0.729, 0.742; Gly, Gln, His, Ile, 0.749, 0.703, 0.9%, 0.718, 0.718; Arg, Lys, Ile, Phe, 0.749, 0.671, 0.9%, 0.657, 0.671; Gln, His, Thr, Ile, 0.749, 0.706, 1.1%, 0.723, 0.734; Gln, Ile, Leu, Phe, 0.749, 0.695, 0.2%, 0.699, 0.643; Gln, Tyr, Lys, Leu, 0.749, 0.719, 3.7%, 0.709, 0.732; His, Tyr, Met, Ile, 0.749, 0.725, 4.8%, 0.726, 0.708; Asn, Met, Lys, Ile, 0.748, 0.674, 2.8%, 0.648, 0.669; Gln, Cit, Orn, Ile, 0.748, 0.683, 3.1%, 0.690, 0.680; Gln, His, Tyr, Leu, 0.748, 0.724, 2.0%, 0.728, 0.742; Gln, Lys, Ile, Phe, 0.748, 0.678, 0.6%, 0.655, 0.659; Asn, Cit, Tyr, Ile, 0.747, 0.728, 5.1%, 0.740, 0.718; Cit, Tyr, Lys, Ile, 0.747, 0.706, 4.2%, 0.702, 0.736; Gln, Lys, Ile, Leu, 0.747, 0.686, 0.7%, 0.663, 0.700; Gln, Lys, Ile, Trp, 0.747, 0.681, 0.9%, 0.657, 0.702; Gln, Val, Lys, Ile, 0.747, 0.677, 1.1%, 0.661, 0.710; Asn, His, Ile, Phe, 0.747, 0.689, 0.9%, 0.690, 0.617; Asn, His, Lys, Ile, 0.747, 0.681, 4.0%, 0.664, 0.655; Asn, Lys, Ile, Leu, 0.747, 0.678, 1.7%, 0.652, 0.659; Gln, His, Orn, Ile, 0.747, 0.697, 1.5%, 0.713, 0.710; Gln, Tyr, Lys, Ile, 0.747, 0.715, 4.4%, 0.714, 0.755; Asn, His, Tyr, Ile, 0.746, 0.721, 4.0%, 0.725, 0.696; Asn, Tyr, Leu, Phe, 0.746, 0.722, 2.6%, 0.712, 0.643; Gln, Ala, Cit, Ile, 0.746, 0.693, 0.7%, 0.708, 0.702; Gln, Cit, Lys, Ile, 0.746, 0.683, 0.7%, 0.674, 0.722; Gln, His, Lys, Ile, 0.746, 0.696, 1.1%, 0.695, 0.714; Gln, Orn, Leu, Phe, 0.746, 0.674, 0.2%, 0.657, 0.596; Gln, Thr, Lys, Ile, 0.746, 0.683, 0.9%, 0.660, 0.704; Ser, Gln, Lys, Ile, 0.746, 0.661, 1.3%, 0.638, 0.710; Ser, Gln, Tyr, Ile, 0.746, 0.711, 5.3%, 0.719, 0.757; Asn, Gln, Ile, Leu, 0.745, 0.700, 0.4%, 0.702, 0.657; Asn, Gln, Leu, Phe, 0.745, 0.683, 0.0%, 0.674, 0.592; Asn, Gly, Tyr, Leu, 0.745, 0.713, 2.4%, 0.694, 0.637; Asn, His, Val, Lys, 0.745, 0.688, 1.5%, 0.670, 0.621; Cit, Tyr, Ile, Phe, 0.745, 0.714, 4.8%, 0.723, 0.708; Cit, Tyr, Orn, Ile, 0.745, 0.703, 4.2%, 0.711, 0.734; Cit, Tyr, Val, Ile, 0.745, 0.717, 5.5%, 0.716, 0.724; Gly, Cit, Tyr, Ile, 0.745, 0.712, 4.2%, 0.713, 0.738; Ser, Gln, His, Ile, 0.745, 0.693, 0.9%, 0.710, 0.734; Asn, Gly, Lys, Ile, 0.745, 0.671, 2.8%, 0.646, 0.663; Gln, Met, Lys, Ile, 0.745, 0.682, 0.9%, 0.658, 0.706; Gln, Orn, Lys, Ile, 0.745, 0.681, 1.1%, 0.657, 0.702; Tyr, Lys, Ile, Phe, 0.745, 0.702, 5.9%, 0.683, 0.669; Tyr, Met, Lys, Ile, 0.745, 0.711, 5.5%, 0.693, 0.714; Asn, Gln, Tyr, Ile, 0.744, 0.723, 6.2%, 0.730, 0.716; Asn, His, Met, Ile, 0.744, 0.695, 1.8%, 0.698, 0.613; Gln, Cit, Pro, Ile, 0.744, 0.700, 0.9%, 0.709, 0.696; His, Arg, Tyr, Ile, 0.744, 0.719, 2.9%, 0.731, 0.734; His, Cit, Tyr, Ile, 0.744, 0.714, 2.9%, 0.724, 0.750; Asn, Orn, Lys, Ile, 0.743, 0.675, 2.4%, 0.653, 0.669; Gln, Arg, Tyr, Ile, 0.743, 0.728, 5.9%, 0.743, 0.753; Gln, Thr, Leu, Phe, 0.743, 0.679, 0.0%, 0.665, 0.611; Gln, Tyr, Met, Ile, 0.743, 0.730, 6.1%, 0.737, 0.738; Gly, Gln, Orn, Leu, 0.743, 0.672, 0.2%, 0.651, 0.613; Asn, Gln, Tyr, Leu, 0.743, 0.727, 2.9%, 0.719, 0.696; Asn, His, Orn, Ile, 0.743, 0.687, 1.3%, 0.688, 0.627; Asn, Lys, Ile, Trp, 0.743, 0.670, 2.0%, 0.649, 0.665; Gln, Cit, Arg, Ile, 0.743, 0.699, 0.4%, 0.711, 0.694; Gln, Lys, Leu, Phe, 0.743, 0.676, 0.0%, 0.647, 0.613; Gly, Gln, Cit, Ile, 0.743, 0.688, 0.7%, 0.689, 0.677; Gly, Gln, Leu, Phe, 0.743, 0.674, 0.0%, 0.652, 0.590; Tyr, Met, Ile, Phe, 0.743, 0.718, 7.5%, 0.711, 0.665; Arg, Pro, Tyr, Lys, 0.742, 0.696, 5.5%, 0.682, 0.777; Asn, Gln, Ile, Phe, 0.742, 0.688, 0.7%, 0.702, 0.659; Asn, Gln, Orn, Ile, 0.742, 0.683, 1.7%, 0.696, 0.680; Asn, Gln, Orn, Leu, 0.742, 0.680, 0.2%, 0.663, 0.598; Asn, Lys, Ile, Phe, 0.742, 0.673, 2.8%, 0.639, 0.639; Cit, Pro, Tyr, Ile, 0.742, 0.717, 4.6%, 0.724, 0.734; Gln, His, Tyr, Phe, 0.742, 0.735, 0.9%, 0.758, 0.759; Gln, Tyr, Met, Leu, 0.742, 0.727, 2.6%, 0.725, 0.714; Ala, Cit, Tyr, Ile, 0.742, 0.718, 4.0%, 0.725, 0.734; Asn, Val, Lys, Ile, 0.742, 0.673, 2.6%, 0.649, 0.663; Gln, Ala, Tyr, Leu, 0.742, 0.717, 2.6%, 0.717, 0.736; Gln, Cit, Ile, Leu, 0.742, 0.698, 0.2%, 0.702, 0.669; Gln, Cit, Ile, Phe, 0.742, 0.692, 0.7%, 0.705, 0.661; Gln, His, Orn, Leu, 0.742, 0.686, 0.6%, 0.680, 0.651; Ser, Gln, Tyr, Leu, 0.742, 0.719, 2.9%, 0.717, 0.734; Arg, Lys, Ile, Leu, 0.741, 0.676, 1.8%, 0.659, 0.677; Arg, Orn, Lys, Ile, 0.741, 0.667, 2.0%, 0.654, 0.675; Asn, His, Ala, Ile, 0.741, 0.694, 2.4%, 0.696, 0.643; Asn, His, Arg, Ile, 0.741, 0.698, 1.3%, 0.708, 0.643; Asn, His, Val, Ile, 0.741, 0.698, 0.9%, 0.698, 0.635; Asn, Tyr, Val, Ile, 0.741, 0.726, 8.3%, 0.714, 0.680; Cit, Tyr, Met, Ile, 0.741, 0.726, 5.1%, 0.725, 0.710; Gln, Ala, Lys, Ile, 0.741, 0.679, 1.1%, 0.661, 0.706; Gln, Cit, Ile, Trp, 0.741, 0.698, 0.4%, 0.710, 0.696; Gln, Cit, Tyr, Leu, 0.741, 0.723, 1.8%, 0.728, 0.738; Gln, His, Tyr, Val, 0.741, 0.727, 2.9%, 0.723, 0.746; Gln, Pro, Lys, Ile, 0.741, 0.678, 1.3%, 0.657, 0.688; Ser, Gln, Leu, Phe, 0.741, 0.667, 0.0%, 0.648, 0.604; Asn, Gln, Val, Lys, 0.740, 0.679, 0.9%, 0.647, 0.623; Asn, Tyr, Lys, Ile, 0.740, 0.702, 6.4%, 0.680, 0.684; Asn, Tyr, Met, Leu, 0.740, 0.724, 3.9%, 0.712, 0.661; Cit, Tyr, Ile, Trp, 0.740, 0.718, 5.0%, 0.720, 0.734; Tyr, Ile, Leu, Phe, 0.740, 0.711, 4.0%, 0.700, 0.655; Tyr, Leu, Phe, Trp, 0.740, 0.714, 2.6%, 0.693, 0.625; Asn, Arg, Tyr, Ile, 0.740, 0.722, 6.2%, 0.728, 0.706; Asn, Tyr, Lys, Leu, 0.740, 0.711, 3.3%, 0.688, 0.659; Cit, Tyr, Ile, Leu, 0.740, 0.709, 3.5%, 0.714, 0.724; Gln, Tyr, Val, Leu, 0.740, 0.723, 2.8%, 0.718, 0.738; Ser, Cit, Tyr, Ile, 0.740, 0.711, 4.2%, 0.718, 0.736; Tyr, Val, Ile, Phe, 0.740, 0.717, 5.9%, 0.706, 0.667; Asn, Lys, Leu, Phe, 0.739, 0.666, 0.4%, 0.628, 0.560; Asn, Pro, Lys, Ile, 0.739, 0.667, 3.1%, 0.638, 0.675; Asn, Tyr, Ile, Leu, 0.739, 0.719, 4.2%, 0.713, 0.667; Asn, Val, Lys, Leu, 0.739, 0.673, 0.6%, 0.637, 0.582; Gln, His, Pro, Tyr, 0.739, 0.727, 3.7%, 0.748, 0.757; Gln, His, Tyr, Lys, 0.739, 0.724, 2.0%, 0.725, 0.775; Gln, Leu, Phe, Trp, 0.739, 0.679, 0.0%, 0.667, 0.592; Gln, Pro, Ile, Phe, 0.739, 0.688, 1.3%, 0.700, 0.673; Gln, Pro, Tyr, Leu, 0.739, 0.718, 2.6%, 0.717, 0.722; Gln, Tyr, Ile, Trp, 0.739, 0.726, 7.0%, 0.728, 0.748; Gln, Tyr, Orn, Leu, 0.739, 0.716, 3.1%, 0.713, 0.726; Gln, Val, Lys, Leu, 0.739, 0.686, 0.2%, 0.656, 0.661; His, Arg, Ile, Phe, 0.739, 0.684, 0.4%, 0.682, 0.641; Asn, Gly, Gln, Leu, 0.738, 0.682, 0.2%, 0.662, 0.594; Asn, His, Ile, Leu, 0.738, 0.695, 0.6%, 0.691, 0.619; Gln, Ile, Leu, Trp, 0.738, 0.698, 0.4%, 0.692, 0.659; Gln, Lys, Leu, Trp, 0.738, 0.682, 0.2%, 0.653, 0.639; Gln, Thr, Ile, Leu, 0.738, 0.696, 0.4%, 0.692, 0.679; Gln, Thr, Tyr, Ile, 0.738, 0.726, 5.7%, 0.738, 0.746; Gln, Val, Leu, Phe, 0.738, 0.680, 0.0%, 0.667, 0.600; Ser, Arg, Lys, Ile, 0.738, 0.659, 0.9%, 0.636, 0.671; Ser, Asn, Lys, Leu, 0.738, 0.664, 0.6%, 0.626, 0.598; Arg, Lys, Ile, Trp, 0.738, 0.673, 1.7%, 0.652, 0.673; Arg, Tyr, Orn, Lys, 0.738, 0.683, 5.3%, 0.684, 0.771; Asn, Tyr, Ile, Phe, 0.738, 0.715, 6.2%, 0.710, 0.659; Cit, Arg, Lys, Ile, 0.738, 0.675, 1.8%, 0.662, 0.675; Gln, Ala, Tyr, Ile, 0.738, 0.725, 5.5%, 0.735, 0.753; Gln, Arg, Tyr, Leu, 0.738, 0.722, 2.0%, 0.722, 0.720; Gln, Orn, Ile, Phe, 0.738, 0.680, 1.1%, 0.692, 0.663; Gln, Orn, Lys, Leu, 0.738, 0.673, 0.2%, 0.643, 0.641; Gln, Thr, Cit, Ile, 0.738, 0.693, 1.1%, 0.705, 0.716; Gln, Thr, Tyr, Leu, 0.738, 0.724, 2.9%, 0.721, 0.724; Tyr, Met, Ile, Leu, 0.738, 0.721, 5.3%, 0.709, 0.677; Tyr, Met, Leu, Phe, 0.738, 0.718, 2.8%, 0.704, 0.639; Asn, Arg, Tyr, Leu, 0.737, 0.721, 2.2%, 0.715, 0.667; Asn, Gly, His, Ile, 0.737, 0.693, 1.1%, 0.695, 0.627; Asn, Gly, Lys, Leu, 0.737, 0.671, 0.6%, 0.631, 0.576; Asn, His, Pro, Ile, 0.737, 0.696, 1.1%, 0.699, 0.629; Asn, Orn, Lys, Leu, 0.737, 0.664, 0.6%, 0.628, 0.570; Gln, Arg, Leu, Phe, 0.737, 0.681, 0.0%, 0.670, 0.588; Gln, Orn, Leu, Trp, 0.737, 0.676, 0.4%, 0.657, 0.613; Gln, Thr, Orn, Leu, 0.737, 0.677, 0.2%, 0.663, 0.625; Gln, Tyr, Val, Ile, 0.737, 0.724, 4.8%, 0.725, 0.738; Gln, Tyr, Val, Trp, 0.737, 0.732, 7.2%, 0.713, 0.722; Gln, Pro, Tyr, Ile, 0.737, 0.724, 4.8%, 0.735, 0.751; Gln, Tyr, Orn, Ile, 0.737, 0.725, 5.3%, 0.733, 0.746; Arg, Met, Lys, Ile, 0.737, 0.672, 1.5%, 0.655, 0.679; Arg, Tyr, Ile, Phe, 0.737, 0.716, 5.0%, 0.722, 0.680; Asn, Cit, Ile, Leu, 0.737, 0.691, 0.6%, 0.685, 0.629; Asn, Gln, Cit, Ile, 0.737, 0.697, 0.6%, 0.711, 0.680; Asn, Gln, Thr, Leu, 0.737, 0.687, 0.2%, 0.678, 0.606; Asn, His, Ile, Trp, 0.737, 0.696, 1.1%, 0.699, 0.629; Cit, Arg, Tyr, Ile, 0.737, 0.722, 2.8%, 0.732, 0.730; Gln, Ala, Ile, Leu, 0.737, 0.693, 0.4%, 0.696, 0.673; Gln, Arg, Ile, Leu, 0.737, 0.698, 0.4%, 0.706, 0.669; Gln, Val, Orn, Ile, 0.737, 0.692, 1.3%, 0.694, 0.671; His, Lys, Ile, Phe, 0.737, 0.670, 1.3%, 0.641, 0.615; Arg, Ile, Leu, Phe, 0.736, 0.678, 0.2%, 0.670, 0.598; Asn, Gln, His, Tyr, 0.736, 0.737, 1.7%, 0.755, 0.753; Asn, Gln, Pro, Ile, 0.736, 0.693, 1.3%, 0.704, 0.686; Asn, Gln, Val, Leu, 0.736, 0.690, 0

.2%, 0.678, 0.609; Asn, His, Thr, Ile, 0.736, 0.697, 0.9%, 0.700, 0.625; Asn, His, Tyr, Val, 0.736, 0.722, 4.6%, 0.708, 0.682; Asn, Tyr, Val, Lys, 0.736, 0.719, 6.4%, 0.688, 0.679; Gln, Cit, Leu, Phe, 0.736, 0.677, 0.0%, 0.662, 0.594; Gln, Cit, Val, Ile, 0.736, 0.700, 0.2%, 0.710, 0.692; Gln, His, Leu, Phe, 0.736, 0.692, 0.0%, 0.687, 0.621; Gln, His, Tyr, Trp, 0.736, 0.728, 0.9%, 0.749, 0.773; Gly, Tyr, Met, Ile, 0.736, 0.714, 7.9%, 0.702, 0.692; Ser, Asn, His, Ile, 0.736, 0.676, 1.3%, 0.675, 0.649; Ser, Gln, Lys, Leu, 0.736, 0.672, 0.2%, 0.639, 0.647; Ser, Gln, Orn, Leu, 0.736, 0.667, 0.2%, 0.648, 0.619; Thr, Cit, Tyr, Ile, 0.736, 0.723, 6.1%, 0.733, 0.726; Tyr, Ile, Phe, Trp, 0.736, 0.709, 6.6%, 0.697, 0.653; Tyr, Orn, Ile, Phe, 0.736, 0.719, 6.1%, 0.714, 0.673; Asn, Ala, Lys, Ile, 0.735, 0.665, 2.9%, 0.642, 0.675; Asn, Gln, Arg, Ile, 0.735, 0.691, 0.7%, 0.712, 0.684; Asn, Gln, Val, Ile, 0.735, 0.697, 0.6%, 0.698, 0.669; Asn, Lys, Leu, Trp, 0.735, 0.670, 0.6%, 0.637, 0.590; Asn, Thr, Tyr, Val, 0.735, 0.728, 9.6%, 0.714, 0.682; Gln, Ala, Lys, Leu, 0.735, 0.673, 0.4%, 0.657, 0.665; Gln, Cit, Met, Ile, 0.735, 0.695, 1.1%, 0.709, 0.720; Gln, Met, Lys, Leu, 0.735, 0.681, 0.2%, 0.655, 0.657; Gln, Orn, Ile, Leu, 0.735, 0.686, 0.9%, 0.680, 0.659; Gln, Thr, Lys, Leu, 0.735, 0.680, 0.2%, 0.655, 0.653; Gln, Val, Ile, Phe, 0.735, 0.695, 0.4%, 0.700, 0.655; Gly, Arg, Lys, Ile, 0.735, 0.669, 1.5%, 0.647, 0.673; Thr, Arg, Lys, Ile, 0.735, 0.674, 1.8%, 0.657, 0.677; Arg, Val, Lys, Ile, 0.735, 0.674, 2.0%, 0.656, 0.677; Asn, His, Cit, Ile, 0.735, 0.700, 0.6%, 0.704, 0.637; Asn, His, Tyr, Leu, 0.735, 0.718, 2.4%, 0.703, 0.651; Gln, His, Tyr, Orn, 0.735, 0.712, 1.5%, 0.733, 0.761; Gln, Met, Ile, Leu, 0.735, 0.694, 0.4%, 0.694, 0.671; Gln, Val, Orn, Leu, 0.735, 0.677, 0.2%, 0.661, 0.613; Gly, Gln, Tyr, Val, 0.735, 0.720, 7.2%, 0.704, 0.714; His, Ile, Leu, Phe, 0.735, 0.676, 0.4%, 0.659, 0.604; His, Ile, Phe, Trp, 0.735, 0.676, 1.1%, 0.667, 0.619; Pro, Tyr, Met, Ile, 0.735, 0.720, 6.1%, 0.715, 0.702; Ser, Asn, Lys, Ile, 0.735, 0.651, 3.1%, 0.621, 0.649; Ser, Asn, Tyr, Leu, 0.735, 0.715, 2.8%, 0.700, 0.649; Thr, Tyr, Ile, Phe, 0.735, 0.715, 6.2%, 0.716, 0.665; Tyr, Met, Ile, Trp, 0.735, 0.720, 7.2%, 0.711, 0.698; Ala, Tyr, Met, Ile, 0.734, 0.719, 6.2%, 0.712, 0.704; Arg, Tyr, Lys, Trp, 0.734, 0.700, 3.3%, 0.695, 0.775; Asn, Gln, Tyr, Val, 0.734, 0.731, 4.6%, 0.715, 0.704; Asn, Orn, Ile, Leu, 0.734, 0.678, 0.7%, 0.667, 0.609; Cit, Arg, Tyr, Lys, 0.734, 0.699, 4.6%, 0.693, 0.777; Cit, Tyr, Leu, Phe, 0.734, 0.709, 1.3%, 0.699, 0.639; Gln, His, Lys, Leu, 0.734, 0.689, 0.4%, 0.667, 0.673; Gln, His, Pro, Leu, 0.734, 0.701, 1.1%, 0.705, 0.667; Gln, Met, Orn, Leu, 0.734, 0.676, 0.2%, 0.662, 0.625; Gln, Pro, Orn, Ile, 0.734, 0.685, 1.7%, 0.691, 0.686; Gly, Arg, Tyr, Ile, 0.734, 0.713, 4.8%, 0.712, 0.694; Gly, Gln, Ile, Phe, 0.734, 0.676, 0.9%, 0.682, 0.659; Gly, Gln, Pro, Ile, 0.734, 0.681, 1.1%, 0.682, 0.690; Ala, Arg, Lys, Ile, 0.733, 0.670, 1.5%, 0.659, 0.686; Ala, Tyr, Leu, Phe, 0.733, 0.698, 1.7%, 0.684, 0.639; Arg, Pro, Lys, Ile, 0.733, 0.672, 1.8%, 0.654, 0.661; Asn, Ala, Tyr, Leu, 0.733, 0.712, 2.4%, 0.701, 0.655; Asn, Gln, Arg, Leu, 0.733, 0.687, 0.2%, 0.677, 0.604; Asn, Tyr, Met, Ile, 0.733, 0.724, 6.2%, 0.722, 0.688; Cit, Ile, Leu, Phe, 0.733, 0.682, 0.6%, 0.675, 0.617; Gln, Ala, Ile, Phe, 0.733, 0.679, 0.9%, 0.690, 0.677; Gln, Ala, Leu, Trp, 0.733, 0.684, 0.6%, 0.673, 0.631; Gln, Cit, Lys, Leu, 0.733, 0.678, 0.2%, 0.650, 0.649; Gln, His, Cit, Tyr, 0.733, 0.727, 1.1%, 0.750, 0.773; Gln, Pro, Val, Ile, 0.733, 0.695, 0.9%, 0.695, 0.677; Gln, Thr, Arg, Ile, 0.733, 0.687, 1.7%, 0.708, 0.710; Gln, Val, Met, Ile, 0.733, 0.698, 0.9%, 0.702, 0.688; Gly, Gln, Lys, Leu, 0.733, 0.672, 0.2%, 0.638, 0.629; Lys, Ile, Leu, Phe, 0.733, 0.670, 1.1%, 0.638, 0.606; Pro, Tyr, Ile, Phe, 0.733, 0.709, 6.6%, 0.701, 0.659; Ser, Asn, Gln, Ile, 0.733, 0.661, 2.8%, 0.669, 0.704; Ser, Asn, Gln, Leu, 0.733, 0.673, 0.2%, 0.657, 0.621; Tyr, Lys, Leu, Phe, 0.733, 0.706, 2.0%, 0.685, 0.623; Arg, Tyr, Val, Lys, 0.733, 0.713, 2.6%, 0.698, 0.714; Asn, Arg, Tyr, Val, 0.733, 0.728, 6.8%, 0.712, 0.684; Asn, Gln, Leu, Trp, 0.733, 0.687, 0.2%, 0.679, 0.606; Asn, Gly, Gln, Ile, 0.733, 0.679, 1.1%, 0.686, 0.679; Asn, Ile, Leu, Phe, 0.733, 0.679, 0.6%, 0.671, 0.588; Asn, Thr, Lys, Leu, 0.733, 0.670, 0.6%, 0.636, 0.582; Asn, Tyr, Orn, Ile, 0.733, 0.727, 9.2%, 0.722, 0.690; Cit, Pro, Lys, Ile, 0.733, 0.678, 3.5%, 0.655, 0.680; Gln, His, Ala, Leu, 0.733, 0.690, 0.7%, 0.694, 0.661; Gln, His, Ala, Tyr, 0.733, 0.726, 2.2%, 0.748, 0.775; Gln, Thr, Ile, Phe, 0.733, 0.678, 1.3%, 0.689, 0.684; Gln, Val, Ile, Leu, 0.733, 0.694, 0.2%, 0.693, 0.667; Gln, Val, Lys, Phe, 0.733, 0.683, 0.4%, 0.646, 0.619; Gly, Arg, Tyr, Lys, 0.733, 0.699, 4.4%, 0.693, 0.775; Gly, Gln, Ile, Leu, 0.733, 0.684, 0.4%, 0.675, 0.645; His, Cit, Ile, Phe, 0.733, 0.680, 0.7%, 0.667, 0.641; Arg, Tyr, Val, Ile, 0.732, 0.719, 4.6%, 0.717, 0.708; Asn, Cit, Ile, Phe, 0.732, 0.686, 0.7%, 0.691, 0.639; Asn, Cit, Orn, Ile, 0.732, 0.672, 1.5%, 0.674, 0.639; Asn, Gln, Ile, Trp, 0.732, 0.690, 1.3%, 0.711, 0.692; Asn, Gly, Val, Lys, 0.732, 0.677, 1.5%, 0.640, 0.586; Asn, Met, Ile, Leu, 0.732, 0.687, 0.7%, 0.677, 0.613; Asn, Tyr, Leu, Trp, 0.732, 0.717, 3.9%, 0.698, 0.643; Asn, Tyr, Val, Leu, 0.732, 0.718, 2.9%, 0.700, 0.655; Asn, Val, Met, Lys, 0.732, 0.680, 1.8%, 0.647, 0.602; Asn, Val, Orn, Lys, 0.732, 0.672, 1.7%, 0.633, 0.580; Cit, Lys, Ile, Phe, 0.732, 0.674, 1.1%, 0.651, 0.647; Gln, His, Ala, Lys, 0.732, 0.679, 1.5%, 0.682, 0.726; Gln, Ile, Phe, Trp, 0.732, 0.685, 0.7%, 0.703, 0.667; Gln, Pro, Ile, Leu, 0.732, 0.695, 0.6%, 0.694, 0.669; Gln, Val, Ile, Trp, 0.732, 0.697, 0.6%, 0.699, 0.682; Ser, Asn, Tyr, Ile, 0.732, 0.706, 8.5%, 0.698, 0.688; Ser, Gln, Arg, Ile, 0.732, 0.663, 2.6%, 0.674, 0.718; Ser, Gln, His, Tyr, 0.732, 0.736, 1.7%, 0.751, 0.755; Ala, Tyr, Ile, Phe, 0.731, 0.706, 6.4%, 0.698, 0.655; Arg, Tyr, Leu, Phe, 0.731, 0.715, 1.3%, 0.708, 0.649; Arg, Tyr, Met, Ile, 0.731, 0.720, 6.6%, 0.722, 0.704; Asn, Cit, Tyr, Leu, 0.731, 0.715, 1.8%, 0.706, 0.667; Asn, Gln, Met, Leu, 0.731, 0.690, 0.2%, 0.678, 0.613; Asn, Gln, Thr, Ile, 0.731, 0.684, 2.0%, 0.696, 0.698; Asn, Gly, Ile, Leu, 0.731, 0.676, 0.6%, 0.659, 0.594; Asn, Gly, Tyr, Ile, 0.731, 0.709, 8.1%, 0.698, 0.669; Asn, Met, Lys, Leu, 0.731, 0.670, 0.7%, 0.634, 0.584; Asn, Val, Lys, Phe, 0.731, 0.674, 0.7%, 0.636, 0.582; Gln, Ala, Met, Leu, 0.731, 0.682, 0.2%, 0.678, 0.635; Gln, Arg, Ile, Phe, 0.731, 0.687, 0.9%, 0.702, 0.657; Gln, His, Cit, Pro, 0.731, 0.694, 1.1%, 0.739, 0.712; Gly, Gln, Orn, Ile, 0.731, 0.675, 1.5%, 0.675, 0.680; His, Orn, Ile, Phe, 0.731, 0.675, 0.9%, 0.664, 0.615; His, Tyr, Leu, Phe, 0.731, 0.707, 1.7%, 0.689, 0.623; Ser, Asn, Val, Lys, 0.731, 0.673, 1.7%, 0.637, 0.598; Asn, Gln, Ala, Leu, 0.731, 0.682, 0.4%, 0.677, 0.619; Asn, His, Lys, Leu, 0.731, 0.675, 1.1%, 0.648, 0.590; Asn, Thr, Val, Lys, 0.731, 0.676, 1.1%, 0.643, 0.588; Gln, Arg, Orn, Leu, 0.731, 0.673, 0.6%, 0.662, 0.623; Gln, His, Arg, Tyr, 0.731, 0.730, 0.7%, 0.754, 0.769; Gln, His, Thr, Tyr, 0.731, 0.731, 1.7%, 0.748, 0.763; Gln, Orn, Ile, Trp, 0.731, 0.682, 1.7%, 0.692, 0.692; Gln, Thr, Leu, Trp, 0.731, 0.685, 0.2%, 0.672, 0.633; Gln, Thr, Val, Ile, 0.731, 0.689, 1.1%, 0.692, 0.694; His, Ala, Ile, Phe, 0.731, 0.671, 1.1%, 0.662, 0.637; His, Val, Ile, Phe, 0.731, 0.681, 0.7%, 0.662, 0.613; Ser, Arg, Tyr, Ile, 0.731, 0.706, 5.5%, 0.710, 0.708; Ser, Gln, Cit, Ile, 0.731, 0.669, 2.0%, 0.675, 0.700; Thr, Tyr, Met, Ile, 0.731, 0.717, 8.3%, 0.712, 0.700; Tyr, Orn, Leu, Phe, 0.731, 0.706, 2.0%, 0.691, 0.629; Tyr, Val, Met, Ile, 0.731, 0.724, 7.2%, 0.712, 0.692; Arg, Tyr, Lys, Leu, 0.730, 0.703, 2.0%, 0.686, 0.686; Asn, Gln, Ala, Ile, 0.730, 0.686, 2.0%, 0.697, 0.690; Asn, Gly, Tyr, Val, 0.730, 0.719, 7.5%, 0.688, 0.655; Asn, Pro, Tyr, Ile, 0.730, 0.720, 7.2%, 0.717, 0.686; Asn, Tyr, Orn, Leu, 0.730, 0.713, 2.8%, 0.700, 0.645; Asn, Tyr, Val, Met, 0.730, 0.725, 7.9%, 0.705, 0.667; Gln, Arg, Ile, Trp, 0.730, 0.692, 0.7%, 0.710, 0.692; Gln, Arg, Tyr, Lys, 0.730, 0.717, 2.2%, 0.717, 0.793; Gln, His, Pro, Phe, 0.730, 0.691, 1.5%, 0.734, 0.702; Gln, Pro, Met, Ile, 0.730, 0.689, 1.3%, 0.698, 0.700; Gln, Thr, Ala, Leu, 0.730, 0.681, 0.2%, 0.680, 0.647; Gln, Tyr, Val, Met, 0.730, 0.727, 5.3%, 0.710, 0.706; Gly, Gln, Val, Ile, 0.730, 0.686, 0.9%, 0.680, 0.665; Gly, His, Ile, Phe, 0.730, 0.678, 0.9%, 0.669, 0.623; Gly, Tyr, Met, Leu, 0.730, 0.706, 4.8%, 0.680, 0.641; His, Arg, Lys, Ile, 0.730, 0.675, 0.7%, 0.662, 0.671; Ser, Gln, Ile, Phe, 0.730, 0.655, 2.8%, 0.664, 0.682; Ser, His, Ile, Phe, 0.730, 0.671, 1.1%, 0.658, 0.627; Gln, Ala, Met, Ile, 0.730, 0.689, 1.8%, 0.699, 0.706; Arg, Tyr, Orn, Leu, 0.730, 0.701, 2.9%, 0.699, 0.673; Asn, Ala, Cit, Ile, 0.730, 0.690, 2.0%, 0.704, 0.692; Asn, Ala, Tyr, Ile, 0.730, 0.718, 8.8%, 0.709, 0.675; Asn, Cit, Val, Lys, 0.730, 0.676, 0.7%, 0.646, 0.604; Asn, Gln, Met, Ile, 0.730, 0.692, 2.2%, 0.701, 0.688; Asn, Val, Ile, Leu, 0.730, 0.686, 0.6%, 0.678, 0.609; Gln, Ala, Orn, Leu, 0.730, 0.670, 1.1%, 0.662, 0.633; Gln, Arg, Orn, Ile, 0.730, 0.679, 2.6%, 0.694, 0.680; Gln, Tyr, Val, Lys, 0.730, 0.719, 4.8%, 0.698, 0.728; His, Arg, Tyr, Lys, 0.730, 0.703, 1.7%, 0.700, 0.779; Ser, Gln, Ile, Leu, 0.730, 0.669, 1.5%, 0.663, 0.684; Ser, Gln, Val, Ile, 0.730, 0.669, 2.0%, 0.668, 0.704; Ser, Tyr, Ile, Phe, 0.730, 0.705, 6.6%, 0.695, 0.647; Thr, Arg, Tyr, Ile, 0.730, 0.717, 8.6%, 0.727, 0.712; Asn, Arg, Tyr, Lys, 0.729, 0.709, 5.3%, 0.694, 0.734; Asn, Gly, Cit, Ile, 0.729, 0.682, 1.1%, 0.681, 0.645; Asn, Orn, Leu, Phe, 0.729, 0.663, 0.6%, 0.639, 0.542; Asn, Thr, Tyr, Leu, 0.729, 0.720, 4.0%, 0.710, 0.659; Gln, Ala, Ile, Trp, 0.729, 0.687, 1.5%, 0.699, 0.698; Gln, Ala, Orn, Ile, 0.729, 0.679, 2.0%, 0.687, 0.692; Gln, Ala, Val, Leu, 0.729, 0.681, 0.2%, 0.678, 0.637; Gln, Arg, Val, Ile, 0.729, 0.696, 0.6%, 0.703, 0.673; Gln, Pro, Ile, Trp, 0.729, 0.689, 1.1%, 0.697, 0.688; Gly, Gln, Ala, Ile, 0.729, 0.680, 1.3%, 0.684, 0.694; Gly, Gln, Met, Ile, 0.729, 0.684, 1.8%, 0.690, 0.702; Gly, Gln, Thr, Ile, 0.729, 0.675, 1.3%, 0.680, 0.702; Gly, Tyr, Ile, Phe, 0.729, 0.703, 6.6%, 0.689, 0.643; His, Met, Lys, Ile, 0.729, 0.672, 2.0%, 0.640, 0.594; His, Thr, Ile, Phe, 0.729, 0.678, 0.7%, 0.667, 0.602; His, Tyr, Ile, T

rp, 0.729, 0.706, 7.2%, 0.695, 0.686; Ser, Gln, His, Leu, 0.729, 0.689, 0.2%, 0.682, 0.663; Ser, Gln, Leu, Trp, 0.729, 0.668, 0.4%, 0.649, 0.631; Ser, Gln, Orn, Ile, 0.729, 0.659, 2.8%, 0.665, 0.716; Ser, Gln, Thr, Ile, 0.729, 0.662, 2.6%, 0.667, 0.716; Ser, Tyr, Met, Ile, 0.729, 0.710, 6.6%, 0.703, 0.704; Arg, Pro, Tyr, Ile, 0.728, 0.715, 5.7%, 0.724, 0.712; Arg, Tyr, Ile, Leu, 0.728, 0.710, 3.3%, 0.712, 0.690; Arg, Tyr, Orn, Ile, 0.728, 0.714, 5.7%, 0.722, 0.710; Asn, Ala, Ile, Trp, 0.728, 0.686, 1.8%, 0.691, 0.671; Asn, Arg, Lys, Leu, 0.728, 0.664, 0.4%, 0.636, 0.606; Asn, Cit, Lys, Leu, 0.728, 0.668, 0.4%, 0.636, 0.572; Asn, Cit, Val, Ile, 0.728, 0.695, 0.7%, 0.694, 0.659; Asn, His, Leu, Phe, 0.728, 0.682, 0.2%, 0.667, 0.566; Asn, Ile, Leu, Trp, 0.728, 0.686, 0.6%, 0.679, 0.611; Asn, Pro, Leu, Phe, 0.728, 0.677, 0.6%, 0.662, 0.572; Asn, Pro, Tyr, Leu, 0.728, 0.713, 2.6%, 0.700, 0.649; Asn, Thr, Ile, Leu, 0.728, 0.684, 0.6%, 0.673, 0.617; Gln, Arg, Pro, Ile, 0.728, 0.692, 1.1%, 0.705, 0.692; Gln, His, Pro, Lys, 0.728, 0.683, 2.9%, 0.688, 0.724; Gln, His, Tyr, Met, 0.728, 0.730, 1.5%, 0.751, 0.753; Gln, Tyr, Val, Phe, 0.728, 0.728, 5.7%, 0.716, 0.692; Gly, Arg, Tyr, Leu, 0.728, 0.703, 2.4%, 0.691, 0.663; Gly, Gln, Arg, Ile, 0.728, 0.679, 1.3%, 0.687, 0.679; Gly, Gln, His, Tyr, 0.728, 0.724, 1.7%, 0.739, 0.755; Gly, Gln, Ile, Trp, 0.728, 0.680, 0.9%, 0.682, 0.682; Gly, Gln, Leu, Trp, 0.728, 0.676, 0.2%, 0.650, 0.606; His, Ala, Met, Ile, 0.728, 0.682, 1.7%, 0.674, 0.631; His, Pro, Ile, Phe, 0.728, 0.675, 1.1%, 0.664, 0.617; Ser, Gln, Pro, Ile, 0.728, 0.663, 2.6%, 0.669, 0.718; Ser, Gln, Val, Lys, 0.728, 0.681, 0.9%, 0.645, 0.639; Thr, Tyr, Val, Phe, 0.728, 0.729, 7.5%, 0.712, 0.673; Tyr, Met, Orn, Ile, 0.728, 0.725, 6.6%, 0.716, 0.700; Tyr, Val, Met, Phe, 0.728, 0.722, 7.0%, 0.698, 0.669; Arg, Tyr, Ile, Trp, 0.728, 0.716, 6.6%, 0.718, 0.704; Asn, Arg, Ile, Leu, 0.728, 0.687, 0.7%, 0.686, 0.617; Asn, Thr, Ile, Phe, 0.728, 0.673, 1.7%, 0.672, 0.623; Asn, Tyr, Val, Orn, 0.728, 0.724, 7.4%, 0.702, 0.665; Asn, Val, Leu, Phe, 0.728, 0.674, 0.4%, 0.652, 0.558; Gln, His, Val, Lys, 0.728, 0.692, 0.9%, 0.668, 0.669; Gln, Met, Ile, Trp, 0.728, 0.688, 1.3%, 0.696, 0.708; Gln, Met, Leu, Phe, 0.728, 0.681, 0.0%, 0.670, 0.627; Gln, Met, Orn, Ile, 0.728, 0.682, 1.8%, 0.693, 0.700; Gln, Thr, Orn, Ile, 0.728, 0.678, 1.7%, 0.685, 0.708; Gln, Thr, Val, Lys, 0.728, 0.683, 0.6%, 0.647, 0.639; Gly, Gln, Ala, Leu, 0.728, 0.674, 0.2%, 0.666, 0.631; Gly, Tyr, Leu, Phe, 0.728, 0.700, 2.2%, 0.676, 0.606; His, Arg, Met, Ile, 0.728, 0.686, 0.6%, 0.687, 0.629; His, Met, Ile, Phe, 0.728, 0.673, 0.9%, 0.661, 0.584; His, Tyr, Lys, Ile, 0.728, 0.697, 6.6%, 0.680, 0.710; Ser, Gln, Ile, Trp, 0.728, 0.659, 2.6%, 0.663, 0.714; Ser, Gly, Gln, Ile, 0.728, 0.662, 2.8%, 0.665, 0.714; Ala, Arg, Tyr, Lys, 0.727, 0.696, 3.7%, 0.682, 0.777; Ala, Cit, Arg, Ile, 0.727, 0.687, 2.6%, 0.700, 0.692; Asn, Gln, His, Leu, 0.727, 0.700, 0.0%, 0.702, 0.643; Asn, Gln, His, Val, 0.727, 0.700, 0.2%, 0.700, 0.655; Asn, Thr, Cit, Ile, 0.727, 0.686, 1.1%, 0.689, 0.661; Asn, Thr, Tyr, Ile, 0.727, 0.719, 9.7%, 0.715, 0.680; Gln, Ala, Pro, Leu, 0.727, 0.684, 0.4%, 0.677, 0.637; Gln, His, Orn, Lys, 0.727, 0.667, 1.3%, 0.660, 0.720; Gln, Pro, Leu, Phe, 0.727, 0.684, 0.2%, 0.678, 0.602; Gln, Pro, Lys, Leu, 0.727, 0.678, 0.7%, 0.658, 0.643; Gln, Thr, Ala, Ile, 0.727, 0.682, 2.2%, 0.692, 0.706; Gln, Tyr, Val, Orn, 0.727, 0.717, 7.0%, 0.704, 0.710; Gly, Gln, His, Leu, 0.727, 0.691, 0.4%, 0.680, 0.647; Gly, Gln, Met, Leu, 0.727, 0.679, 0.2%, 0.657, 0.625; His, Cit, Lys, Ile, 0.727, 0.679, 2.0%, 0.659, 0.673; Ser, Asn, Tyr, Val, 0.727, 0.724, 7.7%, 0.705, 0.663; Ser, Thr, Tyr, Ile, 0.727, 0.700, 11.2%, 0.698, 0.712; Ser, Tyr, Leu, Phe, 0.727, 0.714, 2.0%, 0.699, 0.633; Tyr, Met, Lys, Leu, 0.727, 0.713, 4.0%, 0.686, 0.669; Asn, Ala, Ile, Leu, 0.726, 0.683, 0.7%, 0.674, 0.633; Asn, Arg, Val, Lys, 0.726, 0.674, 1.1%, 0.653, 0.623; Asn, Gln, His, Lys, 0.726, 0.674, 1.8%, 0.669, 0.692; Asn, Gly, Val, Leu, 0.726, 0.676, 0.4%, 0.647, 0.566; Asn, His, Pro, Val, 0.726, 0.693, 0.2%, 0.682, 0.604; Asn, His, Val, Met, 0.726, 0.693, 0.0%, 0.680, 0.613; Asn, Pro, Tyr, Val, 0.726, 0.722, 7.5%, 0.700, 0.661; Asn, Tyr, Ile, Trp, 0.726, 0.714, 9.0%, 0.706, 0.671; Asn, Tyr, Val, Trp, 0.726, 0.725, 7.7%, 0.699, 0.671; Asn, Val, Lys, Trp, 0.726, 0.671, 1.5%, 0.638, 0.602; Gln, Cit, Orn, Leu, 0.726, 0.666, 0.2%, 0.650, 0.621; Gln, Met, Leu, Trp, 0.726, 0.686, 0.2%, 0.672, 0.637; Gln, Thr, Met, Ile, 0.726, 0.684, 1.7%, 0.693, 0.710; Gly, Gln, Thr, Leu, 0.726, 0.678, 0.2%, 0.653, 0.615; Gly, Gln, Val, Lys, 0.726, 0.680, 0.6%, 0.641, 0.625; Met, Lys, Ile, Phe, 0.726, 0.665, 1.3%, 0.628, 0.625; Orn, Lys, Ile, Phe, 0.726, 0.674, 1.3%, 0.636, 0.643; Pro, Tyr, Leu, Phe, 0.726, 0.701, 3.7%, 0.687, 0.621; Ser, Asn, Orn, Leu, 0.726, 0.658, 0.7%, 0.631, 0.558; Ser, Met, Lys, Ile, 0.726, 0.651, 3.3%, 0.616, 0.657; Tyr, Orn, Ile, Trp, 0.726, 0.718, 8.5%, 0.705, 0.702; Tyr, Val, Ile, Trp, 0.726, 0.715, 8.6%, 0.691, 0.684; Val, Lys, Ile, Phe, 0.726, 0.666, 1.7%, 0.629, 0.623; Ala, Arg, Tyr, Ile, 0.726, 0.715, 5.5%, 0.722, 0.708; Arg, Tyr, Lys, Phe, 0.726, 0.700, 3.5%, 0.691, 0.761; Asn, Cit, Ile, Trp, 0.726, 0.690, 0.7%, 0.697, 0.659; Asn, Gly, Leu, Phe, 0.726, 0.669, 0.4%, 0.641, 0.531; Asn, Gly, Leu, Trp, 0.726, 0.673, 0.4%, 0.645, 0.560; Asn, Gly, Orn, Leu, 0.726, 0.662, 0.7%, 0.632, 0.546; Asn, Met, Leu, Phe, 0.726, 0.675, 0.2%, 0.655, 0.554; Gln, Arg, Val, Lys, 0.726, 0.680, 0.9%, 0.653, 0.649; Gln, His, Thr, Leu, 0.726, 0.695, 0.2%, 0.690, 0.659; Gln, Pro, Orn, Leu, 0.726, 0.677, 0.2%, 0.664, 0.623; His, Cit, Met, Ile, 0.726, 0.687, 1.7%, 0.678, 0.633; Ser, Gln, Ala, Leu, 0.726, 0.664, 0.2%, 0.660, 0.647; Ser, Gln, Met, Ile, 0.726, 0.663, 2.9%, 0.666, 0.714; Ser, Gly, Gln, Leu, 0.726, 0.667, 0.2%, 0.644, 0.617; Tyr, Val, Leu, Phe, 0.726, 0.708, 2.4%, 0.690, 0.633; Tyr, Val, Met, Leu, 0.726, 0.717, 5.3%, 0.699, 0.675; Arg, Tyr, Leu, Trp, 0.725, 0.713, 4.6%, 0.698, 0.665; Arg, Val, Orn, Lys, 0.725, 0.663, 1.8%, 0.644, 0.637; Asn, Cit, Arg, Ile, 0.725, 0.688, 0.6%, 0.695, 0.659; Asn, Cit, Pro, Ile, 0.725, 0.687, 1.1%, 0.689, 0.651; Asn, Gln, Pro, Leu, 0.725, 0.690, 0.4%, 0.682, 0.613; Asn, Gly, Cit, Leu, 0.725, 0.670, 0.4%, 0.638, 0.554; Cit, Lys, Ile, Trp, 0.725, 0.676, 1.7%, 0.655, 0.688; Cit, Tyr, Val, Orn, 0.725, 0.701, 5.7%, 0.689, 0.702; Gln, Ala, Arg, Ile, 0.725, 0.689, 1.8%, 0.705, 0.704; Gln, Ala, Arg, Leu, 0.725, 0.683, 0.2%, 0.683, 0.645; Gln, Ala, Val, Ile, 0.725, 0.691, 1.1%, 0.697, 0.682; Gln, Arg, Leu, Trp, 0.725, 0.683, 0.2%, 0.673, 0.625; Gln, Arg, Lys, Leu, 0.725, 0.671, 0.2%, 0.648, 0.653; Gln, Pro, Leu, Trp, 0.725, 0.688, 0.2%, 0.678, 0.625; Gln, Thr, Ile, Trp, 0.725, 0.682, 1.5%, 0.688, 0.704; Gln, Thr, Tyr, Val, 0.725, 0.728, 9.0%, 0.718, 0.716; Gln, Val, Lys, Trp, 0.725, 0.681, 0.6%, 0.646, 0.639; Gly, Tyr, Orn, Ile, 0.725, 0.714, 7.4%, 0.699, 0.702; His, Arg, Orn, Ile, 0.725, 0.672, 1.1%, 0.679, 0.639; His, Thr, Tyr, Ile, 0.725, 0.710, 7.2%, 0.719, 0.708; Ser, Gln, Pro, Leu, 0.725, 0.675, 0.6%, 0.662, 0.641; Thr, Tyr, Orn, Ile, 0.725, 0.720, 9.6%, 0.719, 0.710; Val, Ile, Leu, Phe, 0.725, 0.673, 0.6%, 0.659, 0.586; Val, Met, Lys, Ile, 0.725, 0.672, 2.6%, 0.635, 0.651; Ala, Ile, Leu, Phe, 0.724, 0.673, 0.4%, 0.658, 0.609; Asn, Ala, Lys, Leu, 0.724, 0.666, 0.9%, 0.638, 0.611; Asn, Arg, Orn, Leu, 0.724, 0.664, 0.4%, 0.649, 0.574; Asn, Cit, Met, Ile, 0.724, 0.690, 1.5%, 0.697, 0.667; Asn, Gln, His, Pro, 0.724, 0.691, 2.0%, 0.735, 0.712; Asn, Gly, His, Val, 0.724, 0.693, 0.2%, 0.682, 0.611; Asn, Gly, Thr, Leu, 0.724, 0.670, 0.6%, 0.642, 0.560; Asn, Pro, Ile, Leu, 0.724, 0.683, 0.6%, 0.672, 0.611; Cit, Met, Lys, Ile, 0.724, 0.674, 1.1%, 0.654, 0.679; Cit, Orn, Lys, Ile, 0.724, 0.665, 2.4%, 0.643, 0.661; Cit, Tyr, Leu, Trp, 0.724, 0.709, 3.5%, 0.685, 0.671; Cit, Tyr, Lys, Leu, 0.724, 0.699, 1.8%, 0.688, 0.684; Cit, Tyr, Orn, Leu, 0.724, 0.686, 2.4%, 0.680, 0.669; Gln, Arg, Met, Ile, 0.724, 0.691, 1.7%, 0.711, 0.722; Gln, Val, Orn, Lys, 0.724, 0.677, 0.9%, 0.643, 0.639; Gly, Gln, Pro, Leu, 0.724, 0.683, 0.2%, 0.667, 0.617; Gly, Gln, Val, Leu, 0.724, 0.679, 0.2%, 0.653, 0.609; Pro, Tyr, Ile, Trp, 0.724, 0.709, 7.9%, 0.696, 0.696; Pro, Tyr, Val, Met, 0.724, 0.721, 8.1%, 0.697, 0.669; Thr, Tyr, Ile, Trp, 0.724, 0.713, 11.4%, 0.708, 0.696; Tyr, Orn, Lys, Ile, 0.724, 0.709, 7.5%, 0.687, 0.718; Arg, Orn, Leu, Phe, 0.724, 0.655, 0.2%, 0.638, 0.550; Asn, Ala, Tyr, Val, 0.724, 0.721, 7.0%, 0.698, 0.661; Asn, Arg, Pro, Leu, 0.724, 0.682, 0.6%, 0.674, 0.602; Asn, Arg, Val, Ile, 0.724, 0.690, 1.8%, 0.692, 0.647; Asn, Cit, Tyr, Val, 0.724, 0.723, 4.8%, 0.710, 0.692; Asn, Gln, Cit, Leu, 0.724, 0.685, 0.2%, 0.674, 0.613; Asn, Tyr, Val, Phe, 0.724, 0.722, 5.9%, 0.697, 0.667; Cit, Arg, Ile, Phe, 0.724, 0.683, 0.9%, 0.689, 0.635; Gln, Ala, Pro, Ile, 0.724, 0.685, 1.5%, 0.695, 0.698; Gln, His, Arg, Pro, 0.724, 0.690, 1.3%, 0.737, 0.704; Gln, His, Cit, Lys, 0.724, 0.672, 1.5%, 0.673, 0.724; Gln, His, Leu, Trp, 0.724, 0.696, 0.4%, 0.691, 0.659; Gln, His, Lys, Phe, 0.724, 0.673, 1.5%, 0.676, 0.728; Gln, His, Met, Lys, 0.724, 0.672, 1.5%, 0.674, 0.724; Gln, His, Pro, Met, 0.724, 0.691, 2.2%, 0.735, 0.722; Gly, Gln, His, Pro, 0.724, 0.691, 2.4%, 0.733, 0.718; Gly, Ile, Leu, Phe, 0.724, 0.668, 0.6%, 0.651, 0.582; His, Ala, Arg, Ile, 0.724, 0.683, 1.1%, 0.688, 0.673; His, Arg, Ile, Trp, 0.724, 0.685, 1.8%, 0.688, 0.639; His, Cit, Orn, Ile, 0.724, 0.666, 2.8%, 0.655, 0.631; Ile, Leu, Phe, Trp, 0.724, 0.673, 0.6%, 0.659, 0.586; Ser, Asn, His, Val, 0.724, 0.693, 0.2%, 0.682, 0.604; Ser, Asn, Ile, Leu, 0.724, 0.661, 0.7%, 0.650, 0.629; Ser, Gln, Thr, Leu, 0.724, 0.669, 0.2%, 0.654, 0.641; Ser, His, Tyr, Ile, 0.724, 0.700, 5.5%, 0.692, 0.700; Tyr, Met, Leu, Trp, 0.724, 0.715, 6.1%, 0.690, 0.659; Val, Lys, Leu, Phe, 0.724, 0.664, 0.4%, 0.622, 0.580; Ala, Met, Lys, Ile, 0.723, 0.663, 2.9%, 0.630, 0.679; Ala, Tyr, Met, Leu, 0.723, 0.709, 5.1%, 0.695, 0.669; Arg, Tyr, Met, Lys, 0.723, 0.700, 5.1%, 0.687, 0.757; Asn, Ala, Arg, Ile, 0.723, 0.682, 2.0%, 0.695, 0.667; Asn, His, Ala, Val, 0.723, 0.688, 0.9%, 0.675, 0.627; Asn, His, Orn, Leu, 0.723, 0.669, 0.4%, 0.652, 0.556; Asn, Met, Ile, Trp, 0.723, 0.683, 2.2%, 0.686, 0.647; Asn, Pro, Ile, Trp, 0.723, 0.681, 2.2%, 0.686, 0.

649; Asn, Thr, Leu, Phe, 0.723, 0.670, 0.6%, 0.647, 0.548; Gln, Cit, Leu, Trp, 0.723, 0.681, 0.0%, 0.669, 0.621; Gln, Pro, Met, Leu, 0.723, 0.687, 0.2%, 0.679, 0.627; Gln, Pro, Tyr, Val, 0.723, 0.721, 6.8%, 0.705, 0.712; Gly, Met, Lys, Ile, 0.723, 0.666, 2.6%, 0.632, 0.663; Gly, Tyr, Ile, Trp, 0.723, 0.704, 9.2%, 0.687, 0.686; Gly, Tyr, Val, Met, 0.723, 0.719, 9.2%, 0.689, 0.669; Met, Orn, Lys, Ile, 0.723, 0.673, 1.8%, 0.637, 0.667; Pro, Ile, Leu, Phe, 0.723, 0.670, 0.4%, 0.650, 0.572; Pro, Tyr, Met, Leu, 0.723, 0.712, 6.4%, 0.698, 0.657; Ser, Asn, Ala, Leu, 0.723, 0.666, 0.7%, 0.649, 0.623; Ser, Gln, Ala, Ile, 0.723, 0.657, 2.9%, 0.662, 0.718; Ser, Gln, His, Pro, 0.723, 0.691, 2.4%, 0.733, 0.718; Thr, Pro, Tyr, Ile, 0.723, 0.715, 11.0%, 0.715, 0.708; Ala, Cit, Lys, Ile, 0.723, 0.671, 3.5%, 0.652, 0.686; Arg, Tyr, Met, Leu, 0.723, 0.716, 2.4%, 0.705, 0.673; Asn, Gln, Tyr, Lys, 0.723, 0.719, 7.9%, 0.697, 0.734; Asn, His, Val, Orn, 0.723, 0.685, 0.0%, 0.671, 0.606; Gln, Arg, Pro, Lys, 0.723, 0.660, 5.0%, 0.657, 0.682; Gln, His, Arg, Leu, 0.723, 0.694, 0.0%, 0.695, 0.659; Gln, His, Thr, Lys, 0.723, 0.672, 1.5%, 0.674, 0.722; Gln, His, Thr, Pro, 0.723, 0.691, 2.2%, 0.733, 0.718; Gln, His, Val, Orn, 0.723, 0.692, 1.5%, 0.685, 0.667; Gly, Gln, His, Lys, 0.723, 0.671, 1.5%, 0.672, 0.720; Gly, Lys, Leu, Phe, 0.723, 0.657, 0.4%, 0.616, 0.560; His, Ala, Tyr, Ile, 0.723, 0.701, 5.9%, 0.691, 0.696; His, Cit, Val, Lys, 0.723, 0.675, 1.5%, 0.638, 0.631; His, Pro, Tyr, Ile, 0.723, 0.702, 5.0%, 0.694, 0.704; Thr, Lys, Ile, Phe, 0.723, 0.665, 1.8%, 0.630, 0.629; Thr, Tyr, Met, Leu, 0.723, 0.714, 4.4%, 0.700, 0.669; Ala, Arg, Tyr, Leu, 0.722, 0.702, 1.8%, 0.703, 0.690; Asn, Ala, Arg, Leu, 0.722, 0.679, 0.6%, 0.674, 0.629; Asn, Ala, Orn, Ile, 0.722, 0.682, 2.0%, 0.682, 0.667; Asn, Gly, His, Leu, 0.722, 0.678, 0.4%, 0.662, 0.570; Cit, Pro, Tyr, Leu, 0.722, 0.697, 3.1%, 0.693, 0.686; Cit, Val, Ile, Phe, 0.722, 0.687, 0.6%, 0.680, 0.639; Gln, Cit, Tyr, Val, 0.722, 0.724, 3.9%, 0.715, 0.728; Gln, His, Lys, Trp, 0.722, 0.677, 0.7%, 0.677, 0.724; Gln, Met, Ile, Phe, 0.722, 0.682, 1.1%, 0.695, 0.682; Gln, Thr, Pro, Ile, 0.722, 0.680, 1.3%, 0.687, 0.704; Gly, Arg, Tyr, Val, 0.722, 0.713, 4.2%, 0.695, 0.682; Ser, Asn, Leu, Phe, 0.722, 0.660, 0.6%, 0.635, 0.544; Ser, Gln, Tyr, Val, 0.722, 0.722, 6.4%, 0.707, 0.710; Ser, His, Met, Ile, 0.722, 0.667, 1.7%, 0.653, 0.619; Ser, Thr, Lys, Ile, 0.722, 0.645, 4.6%, 0.608, 0.659; Thr, Ala, Cit, Ile, 0.722, 0.687, 3.9%, 0.690, 0.700; Thr, Cit, Pro, Ile, 0.722, 0.685, 2.4%, 0.677, 0.659; Thr, Ile, Leu, Phe, 0.722, 0.670, 0.4%, 0.655, 0.588; Ala, Cit, Tyr, Leu, 0.721, 0.697, 2.6%, 0.693, 0.688; Arg, Tyr, Val, Phe, 0.721, 0.720, 5.0%, 0.713, 0.690; Asn, Gly, Arg, Leu, 0.721, 0.669, 0.4%, 0.649, 0.574; Asn, Orn, Ile, Trp, 0.721, 0.677, 1.7%, 0.681, 0.649; Asn, Pro, Lys, Leu, 0.721, 0.669, 1.1%, 0.632, 0.570; Gln, Ala, Cit, Leu, 0.721, 0.679, 0.2%, 0.677, 0.631; Gln, Arg, Tyr, Val, 0.721, 0.725, 4.0%, 0.714, 0.722; Gln, His, Met, Leu, 0.721, 0.694, 0.4%, 0.691, 0.655; Gln, Val, Met, Lys, 0.721, 0.683, 0.4%, 0.648, 0.651; Gly, Cit, Lys, Ile, 0.721, 0.673, 1.7%, 0.650, 0.671; His, Lys, Leu, Phe, 0.721, 0.658, 0.4%, 0.617, 0.564; His, Tyr, Orn, Ile, 0.721, 0.710, 4.4%, 0.701, 0.712; Met, Lys, Ile, Leu, 0.721, 0.668, 2.0%, 0.633, 0.633; Orn, Ile, Leu, Phe, 0.721, 0.666, 0.7%, 0.650, 0.582; Ser, Cit, Lys, Ile, 0.721, 0.664, 2.8%, 0.640, 0.677; Ser, Gln, Met, Leu, 0.721, 0.670, 0.2%, 0.653, 0.643; Ser, Gln, Val, Leu, 0.721, 0.672, 0.2%, 0.652, 0.637; Tyr, Val, Lys, Ile, 0.721, 0.699, 6.1%, 0.674, 0.684; Tyr, Val, Met, Lys, 0.721, 0.716, 6.8%, 0.680, 0.688; Val, Ile, Phe, Trp, 0.721, 0.681, 0.9%, 0.664, 0.609; Ala, Met, Ile, Leu, 0.721, 0.679, 1.7%, 0.665, 0.633; Asn, Arg, Ile, Trp, 0.721, 0.683, 1.7%, 0.694, 0.643; Asn, Gly, Met, Leu, 0.721, 0.673, 0.6%, 0.644, 0.562; Asn, Gly, Pro, Leu, 0.721, 0.673, 0.6%, 0.648, 0.564; Asn, His, Ala, Leu, 0.721, 0.681, 0.2%, 0.672, 0.621; Asn, His, Cit, Leu, 0.721, 0.680, 0.2%, 0.669, 0.596; Asn, His, Cit, Val, 0.721, 0.694, 0.4%, 0.682, 0.619; Asn, His, Pro, Leu, 0.721, 0.686, 0.4%, 0.674, 0.592; Asn, His, Thr, Val, 0.721, 0.691, 0.2%, 0.678, 0.602; Asn, Met, Orn, Leu, 0.721, 0.666, 0.7%, 0.642, 0.564; Asn, Thr, Ile, Trp, 0.721, 0.679, 2.0%, 0.680, 0.645; Asn, Thr, Met, Ile, 0.721, 0.679, 2.2%, 0.676, 0.645; Asn, Val, Ile, Phe, 0.721, 0.681, 1.5%, 0.676, 0.623; Cit, Lys, Ile, Leu, 0.721, 0.677, 1.1%, 0.655, 0.663; Cit, Pro, Tyr, Val, 0.721, 0.713, 5.5%, 0.700, 0.714; Gln, His, Ala, Val, 0.721, 0.695, 0.7%, 0.694, 0.673; Gln, His, Pro, Orn, 0.721, 0.670, 3.1%, 0.697, 0.692; Gln, Pro, Val, Leu, 0.721, 0.687, 0.2%, 0.679, 0.627; Gly, Cit, Pro, Ile, 0.721, 0.681, 2.0%, 0.670, 0.647; Gly, His, Tyr, Ile, 0.721, 0.700, 5.5%, 0.692, 0.698; His, Cit, Arg, Ile, 0.721, 0.688, 0.9%, 0.688, 0.657; His, Lys, Ile, Trp, 0.721, 0.672, 2.8%, 0.637, 0.627; Met, Lys, Ile, Trp, 0.721, 0.665, 2.6%, 0.630, 0.659; Thr, Arg, Tyr, Leu, 0.721, 0.710, 3.5%, 0.707, 0.677; Tyr, Lys, Ile, Trp, 0.721, 0.695, 10.1%, 0.664, 0.682; Tyr, Val, Met, Trp, 0.721, 0.721, 9.4%, 0.694, 0.675; Ala, Cit, Orn, Ile, 0.720, 0.670, 2.9%, 0.671, 0.688; Ala, Cit, Pro, Ile, 0.720, 0.687, 3.3%, 0.685, 0.679; Ala, Tyr, Val, Ile, 0.720, 0.708, 6.4%, 0.690, 0.682; Arg, Val, Lys, Phe, 0.720, 0.666, 0.9%, 0.632, 0.606; Asn, Ala, Leu, Phe, 0.720, 0.672, 0.2%, 0.658, 0.596; Asn, Cit, Leu, Phe, 0.720, 0.671, 0.2%, 0.650, 0.552; Asn, Cit, Orn, Leu, 0.720, 0.662, 0.4%, 0.640, 0.572; Asn, Gly, Ile, Phe, 0.720, 0.672, 1.5%, 0.670, 0.617; Asn, Gly, Thr, Ile, 0.720, 0.675, 2.4%, 0.671, 0.641; Asn, Leu, Phe, Trp, 0.720, 0.672, 0.2%, 0.652, 0.546; Asn, Met, Ile, Phe, 0.720, 0.677, 0.9%, 0.678, 0.609; Asn, Pro, Orn, Leu, 0.720, 0.669, 0.6%, 0.648, 0.572; Asn, Val, Orn, Leu, 0.720, 0.668, 0.7%, 0.644, 0.558; Cit, Arg, Pro, Ile, 0.720, 0.684, 1.5%, 0.686, 0.655; Cit, Ile, Leu, Trp, 0.720, 0.681, 0.6%, 0.667, 0.633; Cit, Met, Ile, Phe, 0.720, 0.679, 0.7%, 0.677, 0.633; Cit, Tyr, Val, Met, 0.720, 0.723, 6.6%, 0.706, 0.704; Gln, Ala, Leu, Phe, 0.720, 0.669, 0.0%, 0.665, 0.609; Gln, Ala, Tyr, Val, 0.720, 0.720, 7.0%, 0.703, 0.710; Gln, Cit, Arg, Leu, 0.720, 0.678, 0.2%, 0.665, 0.627; Gln, Pro, Tyr, Lys, 0.720, 0.708, 8.6%, 0.692, 0.751; Gln, Thr, Pro, Leu, 0.720, 0.687, 0.4%, 0.676, 0.631; Gln, Thr, Val, Leu, 0.720, 0.683, 0.2%, 0.667, 0.631; Gln, Val, Leu, Trp, 0.720, 0.685, 0.0%, 0.673, 0.621; Gly, Ala, Cit, Ile, 0.720, 0.682, 3.1%, 0.682, 0.677; Gly, Cit, Ile, Leu, 0.720, 0.676, 0.7%, 0.659, 0.623; Gly, Cit, Ile, Phe, 0.720, 0.675, 0.7%, 0.672, 0.637; Gly, Cit, Tyr, Leu, 0.720, 0.694, 2.6%, 0.678, 0.667; Gly, Cit, Val, Ile, 0.720, 0.684, 1.3%, 0.669, 0.639; Gly, His, Arg, Ile, 0.720, 0.682, 1.1%, 0.683, 0.643; Gly, Tyr, Val, Ile, 0.720, 0.704, 6.6%, 0.683, 0.679; His, Arg, Tyr, Val, 0.720, 0.719, 2.9%, 0.709, 0.696; His, Arg, Val, Lys, 0.720, 0.673, 0.7%, 0.645, 0.641; His, Cit, Ile, Trp, 0.720, 0.684, 2.4%, 0.672, 0.635; His, Met, Ile, Leu, 0.720, 0.679, 2.0%, 0.664, 0.594; His, Tyr, Val, Ile, 0.720, 0.705, 5.7%, 0.693, 0.688; Ser, Arg, Tyr, Leu, 0.720, 0.705, 2.2%, 0.698, 0.682; Ser, Asn, Ala, Ile, 0.720, 0.655, 3.3%, 0.653, 0.679; Ser, Asn, Gly, Leu, 0.720, 0.660, 0.6%, 0.632, 0.562; Ser, Asn, Met, Leu, 0.720, 0.662, 0.7%, 0.637, 0.568; Ser, Gln, Cit, Leu, 0.720, 0.667, 0.2%, 0.650, 0.629; Ser, Tyr, Met, Leu, 0.720, 0.712, 4.8%, 0.696, 0.663; Ser, Tyr, Orn, Ile, 0.720, 0.710, 7.2%, 0.701, 0.714; Thr, Tyr, Lys, Ile, 0.720, 0.701, 9.7%, 0.687, 0.716; Thr, Tyr, Val, Ile, 0.720, 0.719, 9.7%, 0.709, 0.686 [8. Four-variable formula including amino acids]
Gln, His, Tyr, Ile, 0.765, 0.731, 2.4%, 0.755, 0.773; Gln, His, Ile, Phe, 0.763, 0.707, 0.0%, 0.728, 0.682; Gln, Tyr, Ile, Phe, 0.761, 0.729, 6.2%, 0.740, 0.702; Asn, Gln, His, Ile, 0.760, 0.714, 1.1%, 0.735, 0.716; Gln, His, Cit, Ile, 0.759, 0.712, 0.7%, 0.734, 0.728; Asn, Arg, Lys, Ile, 0.757, 0.674, 2.2%, 0.668, 0.684; His, Tyr, Ile, Phe, 0.755, 0.709, 3.9%, 0.703, Gln, His, Met, Ile, 0.754, 0.709, 0.6%, 0.728, 0.718; Asn, Cit, Lys, Ile, 0.753, 0.681, 1.8%, 0.668, 0.682; Gln, His, Arg, Ile, 0.753, 0.709, 0.6%, 0.733, 0.724; Gln, Tyr, Leu, Phe, 0.753, 0.728, 1.8%, 0.729, 0.677; Arg, Tyr, Lys, Ile, 0.752, 0.710, 3.9%, 0.708, 0.742; Gln, His, Val, Ile, 0.752, 0.709, 1.1%, 0.729, 0.730; Gln, His, Ile, Leu, 0.752, 0.709, 0.9%, Lys, Ile, 0.752, 0.679, 1.3%, 0.657, 0.679; 0.728, 0.730; Gln, His, Pro, Ile, 0.752, 0.708, 1.1%, 0.728, 0.734; Gln, Tyr, Leu, Trp, 0.752, 0.726, 4.4%, 0.711, 0.710; 0.752, 0 .720, 4.8%, 0.725, 0.734; Asn, Gln, Lys, Leu, 0.751, 0.679, 0.2%, 0.648, 0.615; Gln, His, Ala, Ile, 0.751, 0.707, 1.1%, 0.728, 0.738; Gln, Tyr, Leu, 0.751, 0.718, 2.8%, 0.706, 0.706; Gln, His, Ile, Trp, 0.750, 0.708, 1.5%, 0.723, 0.714; Thr, Tyr, Leu, Phe, 0.750, 0.721, 2.0% , 0.716, 0.657; Gly, Gln, Lys, Ile, 0.750, 0.676, 0.7%, 0.650, 0.696; Asn, Thr, Lys, Ile, 0.749, 0.674, 2.4%, 0.647, 0.661; Gln, Tyr, Ile, Leu, 0.749, 0.724, 3.9%, 0.729, 0.742; Gly, Gln, His, Ile, 0.749, 0.703, 0.9%, 0.718; 0.718; Arg, Lys, Ile, Phe, 0.749, 0.671, 0.9%, 0.657, 0.671; Gln, His, Thr, Ile, 0.749, 0.706, 1.1%, 0.723, 0.734; Gln, Ile, Leu, Phe, 0.749, 0.695, 0.2%, 0.699, 0.643; Gln, Tyr, Lys, Leu, 0.749, 0.719, 3.7%, 0.709, 0.732; His, Tyr, Met, Ile, 0.749, 0.725, 4.8%, 0.726, 0.708; Asn, Met, Lys , Ile, 0.748, 0.674, 2.8%, 0.648, 0.669; Gln, Cit, Orn, Ile, 0.748, 0.683, 3.1%, 0.690, 0.680; Gln, His, Tyr, Leu, 0.748, 0.724, 2.0%, 0.728, 0.742; Gl n, Lys, Ile, Phe, 0.748, 0.678, 0.6%, 0.655, 0.659; Asn, Cit, Tyr, Ile, 0.747, 0.728, 5.1%, 0.740, 0.718; Cit, Tyr, Lys, Ile, 0.747, 0.706, 4.2%, 0.702, 0.736; Gln, Lys, Ile, Leu, 0.747, 0.686, 0.7%, 0.663, 0.700; Gln, Lys, Ile, Trp, 0.747, 0.681, 0.9%, 0.657, 0.702; Asn, His, Ile, Phe, 0.747, 0.689, 0.9%, 0.690, 0.617; Asn, His, Lys, Ile, 0.747, 0.681, 4.0%, 0.664, Asn, Lys, Ile, Leu, 0.747, 0.678, 1.7%, 0.652, 0.659; Gln, His, Orn, Ile, 0.747, 0.697, 1.5%, 0.713, 0.710; Gln, Tyr, Lys, Ile, 0.747, 0.715, 4.4%, 0.714, 0.755; Asn, His, Tyr, Ile, 0.746, 0.721, 4.0%, 0.725, 0.696; Asn, Tyr, Leu, Phe, 0.746, 0.722, 2.6%, 0.712, 0.643; , Cit, Ile, 0.746, 0.693, 0.7%, 0.708, 0.702; Gln, Cit, Lys, Ile, 0.746, 0.683, 0.7%, 0.674, 0.722; Gln, His, Lys, Ile, 0.746, 0.696, 1.1%, Gln, Orn, Leu, Phe, 0.746, 0.674, 0.2%, 0.657, 0.596; Gln, Thr, Lys, Ile, 0.746, 0.683, 0.9%, 0.660, 0.704; Ser, Gln, Lys, Ile, 0.746, 0.6 61, 1.3%, 0.638, 0.710; Ser, Gln, Tyr, Ile, 0.746, 0.711, 5.3%, 0.719, 0.757; Asn, Gln, Ile, Leu, 0.745, 0.700, 0.4%, 0.702, 0.657; Asn, Gly, Tyr, Leu, 0.745, 0.713, 2.4%, 0.694, 0.637; Asn, His, Val, Lys, 0.745, 0.688, 1.5%, Cit, Tyr, Ile, Phe, 0.745, 0.714, 4.8%, 0.723, 0.708; Cit, Tyr, Orn, Ile, 0.745, 0.703, 4.2%, 0.711, 0.734; Cit, Tyr, Val, Ile, Gly, Cit, Tyr, Ile, 0.745, 0.712, 4.2%, 0.713, 0.738; Ser, Gln, His, Ile, 0.745, 0.693, 0.9%, 0.710, 0.734; Asn , Gly, Lys, Ile, 0.745, 0.671, 2.8%, 0.646, 0.663; Gln, Met, Lys, Ile, 0.745, 0.682, 0.9%, 0.658, 0.706; Gln, Orn, Lys, Ile, 0.745, 0.681, 1.1 %, 0.657, 0.702; Tyr, Lys, Ile, Phe, 0.745, 0.702, 5.9%, 0.683, 0.669; Tyr, Met, Lys, Ile, 0.745, 0.711, 5.5%, 0.693, 0.714; Ile, 0.744, 0.723, 6.2%, 0.730, 0.716; Asn, His, Met, Ile, 0.744, 0.695, 1.8%, 0.698, 0.613; Gln, Cit, Pro, Ile, 0.744, 0.700, 0.9%, 0.709, 0.696 His, Arg, Tyr, Ile, 0.744, 0.719, 2.9%, 0.731, 0.734; His, Cit, Tyr, Ile, 0.744, 0.714, 2.9%, 0.724, 0.750; Asn, Orn, Lys, Ile, 0.743, 0.675, 2.4% , 0.653, 0.669; Gln, Arg, Tyr, Ile, 0.743, 0.728, 5.9%, 0.743, 0.753; Gln, Thr, Leu, Phe, 0.743, 0.679, 0.0%, 0.665, 0.611; Gly, Gln, Orn, Leu, 0.743, 0.672, 0.2%, 0.651, 0.613; Asn, Gln, Tyr, Leu, 0.743, 0.727, 2.9%, 0.719, 0.619; Asn, His, Orn, Ile, 0.743, 0.687, 1.3%, 0.688, 0.627; Asn, Lys, Ile, Trp, 0.743, 0.670, 2.0%, 0.649, 0.665; Gln, Cit, Arg, Ile, 0.743, 0.699, Gln, Lys, Leu, Phe, 0.743, 0.676, 0.0%, 0.647, 0.613; Gly, Gln, Cit, Ile, 0.743, 0.688, 0.7%, 0.689, 0.677; Gly, Gln, Leu , Phe, 0.743, 0.674, 0.0%, 0.652, 0.590; Tyr, Met, Ile, Phe, 0.743, 0.718, 7.5%, 0.711, 0.665; Asn, Gln, Ile, Phe, 0.742, 0.688, 0.7%, 0.702, 0.659; Asn, Gln, Orn, Ile, 0.742, 0.683, 1.7%, 0.696, 0.680; Asn, Gln, Orn, Leu, 0.742, 0.680 Asn, Lys, Ile, Phe, 0.742, 0.673, 2.8%, 0.639, 0.639; Cit, Pro, Tyr, Ile, 0.742, 0.717, 4.6%, 0.724, 0.734; Gln, His, Tyr, Phe, 0.742, 0.735, 0.9%, 0.758, 0.759; Gln, Tyr, Met, Leu, 0.742, 0.727, 2.6%, 0.725, 0.714; Ala, Cit, Tyr, Ile, 0.742, 0.718, 4.0%, 0.725 Asn, Val, Lys, Ile, 0.742, 0.673, 2.6%, 0.649, 0.663; Gln, Ala, Tyr, Leu, 0.742, 0.717, 2.6%, 0.717, 0.736; Gln, Cit, Ile, Leu, 0.742 , 0.698, 0.2%, 0.702, 0.669; Gln, Cit, Ile, Phe, 0.742, 0.692, 0.7%, 0.705, 0.661; Gln, Tyr, Leu, 0.742, 0.719, 2.9%, 0.717, 0.734; Arg, Lys, Ile, Leu, 0.741, 0.676, 1.8%, 0.659, 0.677; Arg, Orn, Lys, Ile, 0.741, 0.667, 2.0% , 0.654, 0.675; Asn, His, Ala, Ile, 0.741, 0.694, 2.4%, 0.696, 0.643; Asn, His, Arg, Ile, 0.741, 0.698, 1.3%, 0.708, 0.643; Asn, His, Val, Ile Asn, Tyr, Val, Ile, 0.741, 0.726, 8.3%, 0.714, 0.680; Cit, Tyr, Met, Ile, 0.741, 0.726, 5.1%, 0.725, 0.710; Gln, A la, Lys, Ile, 0.741, 0.679, 1.1%, 0.661, 0.706; Gln, Cit, Ile, Trp, 0.741, 0.698, 0.4%, 0.710, 0.696; Gln, Cit, Tyr, Leu, 0.741, 0.723, 1.8% , 0.728, 0.738; Gln, His, Tyr, Val, 0.741, 0.727, 2.9%, 0.723, 0.746; , 0.741, 0.667, 0.0%, 0.648, 0.604; Asn, Gln, Val, Lys, 0.740, 0.679, 0.9%, 0.647, 0.623; Asn, Tyr, Lys, Ile, 0.740, 0.702, 6.4%, 0.680, 0.684; Asn, Tyr, Met, Leu, 0.740, 0.724, 3.9%, 0.712, 0.661; Cit, Tyr, Ile, Trp, 0.740, 0.718, 5.0%, 0.720, 0.734; Tyr, Ile, Leu, Phe, 0.740, 0.711, 4.0%, 0.700, 0.655; Tyr, Leu, Phe, Trp, 0.740, 0.714, 2.6%, 0.693, 0.625; Asn, Arg, Tyr, Ile, 0.740, 0.722, 6.2%, 0.728, 0.706; Asn, Tyr, Lys Cit, Tyr, Ile, Leu, 0.740, 0.709, 3.5%, 0.714, 0.724; Gln, Tyr, Val, Leu, 0.740, 0.723, 2.8%, 0.718, Ser, Cit, Tyr, Ile, 0.740, 0.711, 4.2%, 0.718, 0.736; Tyr, Val, Ile, Phe, 0.740, 0.717, 5.9%, 0.706, 0.667; Asn, Lys, Leu, Phe, 0.739, 0.666, 0.4%, 0.628, 0.560; Asn, Pro, Lys, Ile, 0.739, 0.667, 3.1%, 0.638, 0.675; Asn, Tyr, Ile, Leu, 0.739, 0.719, 4.2%, 0.713, 0.667; Asn, Val, Lys , Leu, 0.739, 0.673, 0.6%, 0.637, 0.582; Gln, His, Pro, Tyr, 0.739, 0.727, 3.7%, 0.748, 0.757; Gln, His, Tyr, Lys, 0.739, 0.724, 2.0%, 0.725, Gln, Leu, Phe, Trp, 0.739, 0.679, 0.0%, 0.667, 0.592; Gln, Pro, Ile, Phe, 0.739, 0.688, 1.3%, 0.700, 0.673; Gln, Pro, Tyr, Leu, 0.739, 0.718, 2.6%, 0.717, 0.722; Gln, Tyr, Ile, Trp, 0.739, 0.726, 7.0%, 0.728, 0.748; Gln, Tyr, Orn, Leu, 0.739, 0.716, 3.1%, 0.713, 0.726; , Lys, Leu, 0.739, 0.686, 0.2%, 0.656, 0.661; His, Arg, Ile, Phe, 0.739, 0.684, 0.4%, 0.682, 0.641; Asn, His, Ile, Leu, 0.738, 0.695, 0.6%, 0.691, 0.619; Gln, Ile, Leu, Trp, 0.738, 0.698, 0.4%, 0.692, 0.659; Gln, Lys, Leu, Trp, 0.738, 0.682, 0.2%, 0.653, 0.639; Gln, Thr, Ile, Leu, 0.738, 0.696, 0.4%, 0.692, 0.679; Gln, Thr, Tyr, Ile, 0.738, 0.726, 5.7%, 0.738, 0.746 , Val Ser, Arg, Lys, Ile, 0.738, 0.659, 0.9%, 0.636, 0.671; Ser, Asn, Lys, Leu, 0.738, 0.664, 0.6%, Arg, Lys, Ile, Trp, 0.738, 0.673, 1.7%, 0.652, 0.673; Arg, Tyr, Orn, Lys, 0.738, 0.683, 5.3%, 0.684, 0.771; Asn, Tyr, Ile, Phe, 0.738, 0.715, 6.2%, 0.710, 0.659; Cit, Arg, Lys, Ile, 0.738, 0.675, 1.8%, 0.662, 0.675; Gln, Ala, Tyr, Ile, 0.738, 0.725, 5.5%, 0.735, 0.753; , Arg, Tyr, Leu, 0.738, 0.722, 2.0%, 0.722, 0.720; Gln, Orn, Ile, Phe, 0.738, 0.680, 1.1%, 0.692, 0.663; Gln, Orn, Lys, Leu, 0.738, 0.673, 0.2 %, 0.643, 0.641; Gln, Thr, Cit, Ile, 0.738, 0.693, 1.1%, 0.705, 0.716; Gln, Thr, Tyr, Leu, 0.738, 0.724, 2.9%, 0.721, 0.724; Leu, 0.738, 0.721, 5.3%, 0.709, 0.677; Tyr, Met, Leu, Phe, 0.738, 0.718, 2.8%, 0.704, 0.639; Asn, Arg, Tyr, Leu, 0.737, 0.721, 2.2%, 0.717, 0.66 Asn, Gly, His, Ile, 0.737, 0.693, 1.1%, 0.695, 0.627; Asn, Gly, Lys, Leu, 0.737, 0.671, 0.6%, 0.631, 0.576; Asn, His, Pro, Ile, 0.737, 0.696 , 1. 1%, 0.699, 0.629; Asn, Orn, Lys, Leu, 0.737, 0.664, 0.6%, 0.628, 0.570; Gln, Arg, Leu, Phe, 0.737, 0.681, 0.0%, 0.670, 0.588; , Trp, 0.737, 0.676, 0.4%, 0.657, 0.613; Gln, Thr, Orn, Leu, 0.737, 0.677, 0.2%, 0.663, 0.625; Gln, Tyr, Val, Ile, 0.737, 0.724, 4.8%, 0.725, Gln, Tyr, Val, Trp, 0.737, 0.732, 7.2%, 0.713, 0.722; Gln, Pro, Tyr, Ile, 0.737, 0.724, 4.8%, 0.735, 0.751; Gln, Tyr, Orn, Ile, 0.737, Arg, Met, Lys, Ile, 0.737, 0.672, 1.5%, 0.655, 0.679; Arg, Tyr, Ile, Phe, 0.737, 0.716, 5.0%, 0.722, 0.680; Asn, Cit , Ile, Leu, 0.737, 0.691, 0.6%, 0.685, 0.629; Asn, Gln, Cit, Ile, 0.737, 0.697, 0.6%, 0.711, 0.680; Asn, Gln, Thr, Leu, 0.737, 0.687, 0.2%, Asn, His, Ile, Trp, 0.737, 0.696, 1.1%, 0.699, 0.629; Cit, Arg, Tyr, Ile, 0.737, 0.722, 2.8%, 0.732, 0.730; Gln, Ala, Ile, Leu, Gln, Arg, Ile, Leu, 0.737, 0.698, 0.4%, 0.706, 0.669; Gln, Val, Orn, Ile, 0.737, 0.692, 1.3%, 0.694, His 0.671; , Lys, Arg, Ile, Leu, Phe, 0.736, 0.678, 0.2%, 0.670, 0.598; Asn, Gln, His, Tyr, 0.736, 0.737, 1.7%, 0.755 , 0.753; Asn, Gln, Pro, Ile, 0.736, 0.693, 1.3%, 0.704, 0.686; Asn, Gln, Val, Leu, 0.736, 0.690, 0

Asn, His, Thr, Ile, 0.736, 0.697, 0.9%, 0.700, 0.625; Asn, His, Tyr, Val, 0.736, 0.722, 4.6%, 0.708, 0.682; Asn, Tyr, Val, Lys, 0.736, 0.719, 6.4%, 0.688, 0.679; Gln, Cit, Leu, Phe, 0.736, 0.677, 0.0%, 0.662, 0.594; Gln, Cit, Val, Ile, 0.736, 0.700, 0.2%, 0.710 , 0.692; Gln, His, Leu, Phe, 0.736, 0.692, 0.0%, 0.687, 0.621; Gln, His, Tyr, Trp, 0.736, 0.728, 0.9%, 0.749, 0.773; Ser, Asn, His, Ile, 0.736, 0.676, 1.3%, 0.675, 0.649; Ser, Gln, Lys, Leu, 0.736, 0.672, 0.2%, 0.639, 0.647; Gln, Orn, Leu, 0.736, 0.667, 0.2%, 0.648, 0.619; Thr, Cit, Tyr, Ile, 0.736, 0.723, 6.1%, 0.733, 0.726; Tyr, Ile, Phe, Trp, 0.736, 0.709, 6.6% , 0.697, 0.653; Tyr, Orn, Ile, Phe, 0.736, 0.719, 6.1%, 0.714, 0.673; Asn, Ala, Lys, Ile, 0.735, 0.665, 2.9%, 0.642, 0.675; , 0.735, 0.691, 0.7%, 0.712, 0.684; Asn, Gln, Val, Ile, 0.735, 0.697, 0.6%, 0.698, 0.669; Asn, Lys, Leu, Trp, 0.735, 0.670, 0.6%, 0.637, 0.590; Asn, Thr, Tyr, Val, 0.735, 0.728, 9.6%, 0.714, 0.682; Gln, Ala, Lys, Leu, 0.735, 0.673, 0.4%, 0.657, 0.665; Gln, Cit, Met, Ile, 0.735, 0.695, 1.1%, 0.709 , 0.720; Gln, Met, Lys, Leu, 0.735, 0.681, 0.2%, 0.655, 0.657; Gln, Orn, Ile, Leu, 0.735, 0.686, 0.9%, 0.680, 0.659; Gln, Thr, Lys, Leu, 0.735 Gln, Val, Ile, Phe, 0.735, 0.695, 0.4%, 0.700, 0.655; Gly, Arg, Lys, Ile, 0.735, 0.669, 1.5%, 0.647, 0.673; Thr, Arg, Lys, Ile, 0.735, 0.674, 1.8%, 0.657, 0.677; Arg, Val, Lys, Ile, 0.735, 0.674, 2.0%, 0.656, 0.677; Asn, His, Cit, Ile, 0.735, 0.700, 0.6% , 0.704, 0.637; Asn, His, Tyr, Leu, 0.735, 0.718, 2.4%, 0.703, 0.651; Gln, His, Tyr, Orn, 0.735, 0.712, 1.5%, 0.733, 0.761; Gln, Val, Orn, Leu, 0.735, 0.677, 0.2%, 0.661, 0.613; Gly, Gln, Tyr, Val, 0.735, 0.720, 7.2%, 0.704, 0.714; His, Ile, Leu, Phe, 0.735, 0.676, 0.4%, 0.659, 0.604; His, Ile, Phe, Trp, 0.735, 0.676, 1.1%, 0.667, 0.619; Pro, Tyr, Met, Ile, 0.735, 0.720, 6.1 Ser, Asn, Lys, Ile, 0.735, 0.651, 3.1%, 0.621, 0.649; Ser, Asn, Tyr, Leu, 0.735, 0.715, 2.8%, 0.700, 0.649; Thr, Tyr, Ile, Phe, 0.735, 0.715, 6.2%, 0.716, 0.665; Tyr, Met, Ile, Trp, 0.735, 0.720, 7.2%, 0.711, 0.698; Ala, Tyr, Met, Ile, 0.734, 0.719, 6.2%, 0.714, 0.70 Arg, Tyr, Lys, Trp, 0.734, 0.700, 3.3%, 0.695, 0.775; Asn, Gln, Tyr, Val, 0.734, 0.731, 4.6%, 0.715, 0.704; Asn, Orn, Ile, Leu, 0.734, 0.678 , 0.7%, 0.667, 0.609; Cit, Arg, Tyr, Lys, 0.734, 0.699, 4.6%, 0.693, 0.777; Cit, Tyr, Leu, Phe, 0.734, 0.709, 1.3%, 0.699, 0.639; Lys, Leu, 0.734, 0.689, 0.4%, 0.667, 0.673; Gln, His, Pro, Leu, 0.734, 0.701, 1.1%, 0.705, 0.667; Gln, Met, Orn, Leu, 0.734, 0.676, 0.2%, 0.662 , 0.625; Gln, Pro, Orn, Ile, 0.734, 0.685, 1.7%, 0.691, 0.686; Gly, Arg, Tyr, Ile, 0.734, 0.713, 4.8%, 0.712, 0.694; Gly, Gln, Pro, Ile, 0.734, 0.681, 1.1%, 0.682, 0.690; Ala, Arg, Lys, Ile, 0.733, 0.670, 1.5%, 0.659, 0.686; Tyr, L eu, Phe, 0.733, 0.698, 1.7%, 0.684, 0.639; Arg, Pro, Lys, Ile, 0.733, 0.672, 1.8%, 0.654, 0.661; Asn, Ala, Tyr, Leu, 0.733, 0.712, 2.4%, 0.701 , 0.655; Asn, Gln, Arg, Leu, 0.733, 0.687, 0.2%, 0.677, 0.604; Asn, Tyr, Met, Ile, 0.733, 0.724, 6.2%, 0.722, 0.688; Gln, Ala, Ile, Phe, 0.733, 0.679, 0.9%, 0.690, 0.677; Gln, Ala, Leu, Trp, 0.733, 0.684, 0.6%, 0.673, 0.631; Cit, Lys, Leu, 0.733, 0.678, 0.2%, 0.650, 0.649; Gln, His, Cit, Tyr, 0.733, 0.727, 1.1%, 0.750, 0.773; Gln, Pro, Val, Ile, 0.733, 0.695, 0.9% , 0.695, 0.677; Gln, Thr, Arg, Ile, 0.733, 0.687, 1.7%, 0.708, 0.710; Gln, Val, Met, Ile, 0.733, 0.698, 0.9%, 0.702, 0.688; Lys, Ile, Leu, Phe, 0.733, 0.670, 1.1%, 0.638, 0.606; Pro, Tyr, Ile, Phe, 0.733, 0.709, 6.6%, 0.701, 0.659; Ser, Asn, Gln, Ile, 0.733, 0.661, 2.8%, 0.669, 0.704; Ser, Asn, Gln, Leu, 0.733, 0.673, 0.2%, 0.657, 0.621; Tyr, Lys, Leu, Phe, 0.733, 0.706, 2.0%, Arg, Tyr, Val, Lys, 0.733, 0.713, 2.6%, 0.698, 0.714; Asn, Arg, Tyr, Val, 0.733, 0.728, 6.8%, 0.712, 0.684; Asn, Gln, Leu, Trp, 0.733, 0.687, 0.2%, 0.679, 0.606; Asn, Gly, Gln, Ile, 0.733, 0.679, 1.1%, 0.686, 0.679; Asn, Ile, Leu, Phe, 0.733, 0.679, 0.6%, 0.671, 0.588; Asn, Tyr, Orn, Ile, 0.733, 0.727, 9.2%, 0.722, 0.690; Cit, Pro, Lys, Ile, 0.733, 0.678, 3.5 %, 0.655, 0.680; Gln, His, Ala, Leu, 0.733, 0.690, 0.7%, 0.694, 0.661; Gln, His, Ala, Tyr, 0.733, 0.726, 2.2%, 0.748, 0.775; Phe, 0.733, 0.678, 1.3%, 0.689, 0.684; Gln, Val, Ile, Leu, 0.733, 0.694, 0.2%, 0.693, 0.667; Gln, Val, Lys, Phe, 0.733, 0.683, 0.4%, 0.646, 0.6 Gly, Arg, Tyr, Lys, 0.733, 0.699, 4.4%, 0.693, 0.775; Gly, Gln, Ile, Leu, 0.733, 0.684, 0.4%, 0.675, 0.645; His, Cit, Ile, Phe, 0.733, 0.680 Arg, Tyr, Val, Ile, 0.732, 0.719, 4.6%, 0.717, 0.708; Asn, Cit, Ile, Phe, 0.732, 0.686, 0.7%, 0.691, 0.639; Asn, Cit, Orn Asn, Gln, Ile, Trp, 0.732, 0.690, 1.3%, 0.711, 0.692; Asn, Gly, Val, Lys, 0.732, 0.677, 1.5%, 0.640, Asn, Met, Ile, Leu, 0.732, 0.687, 0.7%, 0.677, 0.613; Asn, Tyr, Leu, Trp, 0.732, 0.717, 3.9%, 0.698, 0.643; Asn, Tyr, Val, Leu, 0.732, Asn, Val, Met, Lys, 0.732, 0.680, 1.8%, 0.647, 0.602; Asn, Val, Orn, Lys, 0.732, 0.672, 1.7%, 0.633, 0.580; Cit, Lys , Ile, Phe, 0.732, 0.674, 1.1%, 0.651, 0.647; Gln, His, Ala, Lys, 0.732, 0.679, 1.5%, 0.682, 0.726; Gln, Ile, Phe, Trp, 0.732, 0.685, 0.7%, Gln, Pro, Ile, Leu, 0.732, 0.695, 0.6%, 0.694, 0.669; Gln, Val, Ile, Trp, 0.732, 0.697, 0.6%, 0.699, 0.682; Ser, Gln, Arg, Ile, 0.732, 0.663, 2.6%, 0.674, 0.718; Ser, Gln, His, Tyr, 0.732, 0.736, 1.7%, 0.751, 0.755; , Tyr, Ile, Phe, 0.731, 0.706, 6.4%, 0.698, 0.655; Arg, Tyr, Leu, Phe, 0.731, 0.715, 1.3%, 0.708, 0.649; Arg, Tyr, Met, Ile, 0.731, 0.720, 6.6 %, 0 Asn, Cit, Tyr, Leu, 0.731, 0.715, 1.8%, 0.706, 0.667; Asn, Gln, Met, Leu, 0.731, 0.690, 0.2%, 0.678, 0.613; Asn, Gln, Thr, Ile , 0.731, 0.684, 2.0%, 0.696, 0.698; Asn, Gly, Ile, Leu, 0.731, 0.676, 0.6%, 0.659, 0.594; Asn, Gly, Tyr, Ile, 0.731, 0.709, 8.1%, 0.698, 0.669; Asn, Met, Lys, Leu, 0.731, 0.670, 0.7%, 0.634, 0.584; Asn, Val, Lys, Phe, 0.731, 0.674, 0.7%, 0.636, 0.582; Gln, Ala, Met, Leu, 0.731, 0.682, 0.2%, 0.678, 0.635; Gln, Arg, Ile, Phe, 0.731, 0.687, 0.9%, 0.702, 0.657; Gln, His, Cit, Pro, 0.731, 0.694, 1.1%, 0.739, 0.712; His, Orn, Ile, Phe, 0.731, 0.675, 0.9%, 0.664, 0.615; His, Tyr, Leu, Phe, 0.731, 0.707, 1.7%, 0.689, Ser, Asn, Val, Lys, 0.731, 0.673, 1.7%, 0.637, 0.598; Asn, Gln, Ala, Leu, 0.731, 0.682, 0.4%, 0.677, 0.619; Asn, His, Lys, Leu, 0.731, Asn, Thr, Val, Lys, 0.731, 0.676, 1.1%, 0.643, 0.588; Gln, Arg, Orn, Leu, 0.731, 0.673, 0.6%, 0.662, 0.623; Gln, His , Arg, Tyr, 0.731, 0.730, 0.7%, 0.754, 0.769; Gln, His, Thr, Tyr, 0.731, 0.731, 1.7%, 0.748, 0.763; Gln, Orn, Ile, Trp, 0.731, 0.682, 1.7%, 0.692, 0.6 Gln, Thr, Leu, Trp, 0.731, 0.685, 0.2%, 0.672, 0.633; Gln, Thr, Val, Ile, 0.731, 0.689, 1.1%, 0.692, 0.694; His, Ala, Ile, Phe, 0.731, 0.671 His, Val, Ile, Phe, 0.731, 0.681, 0.7%, 0.662, 0.613; Ser, Arg, Tyr, Ile, 0.731, 0.706, 5.5%, 0.710, 0.708; Ser, Gln, Cit, Ile, 0.731, 0.669, 2.0%, 0.675, 0.700; Thr, Tyr, Met, Ile, 0.731, 0.717, 8.3%, 0.712, 0.700; Tyr, Orn, Leu, Phe, 0.731, 0.706, 2.0%, 0.691 , 0.629; Tyr, Val, Met, Ile, 0.731, 0.724, 7.2%, 0.712, 0.692; Arg, Tyr, Lys, Leu, 0.730, 0.703, 2.0%, 0.686, 0.686; , 0.686, 2.0%, 0.697, 0.690; Asn, Gly, Tyr, Val, 0.730, 0.719, 7.5%, 0.688, 0.655; Asn, Pro, Tyr, Ile, 0.730, 0.720, 7.2%, 0.717, 0.686; Tyr, Orn, Leu, 0.730, 0.713, 2.8%, 0.700, 0.645; Asn, Tyr, Val, Met, 0.730, 0.725, 7.9%, 0.705, 0.667; Gln, Arg, Ile, Trp, 0.730, 0.692, 0.7% , 0.7 10, 0.692; Gln, Arg, Tyr, Lys, 0.730, 0.717, 2.2%, 0.717, 0.793; Gln, His, Pro, Phe, 0.730, 0.691, 1.5%, 0.734, 0.702; 0.730, 0.689, 1.3%, 0.698, 0.700; Gln, Thr, Ala, Leu, 0.730, 0.681, 0.2%, 0.680, 0.647; Gln, Tyr, Val, Met, 0.730, 0.727, 5.3%, 0.710, 0.706; , Gln, Val, Ile, 0.730, 0.686, 0.9%, 0.680, 0.665; Gly, His, Ile, Phe, 0.730, 0.678, 0.9%, 0.669, 0.623; Gly, Tyr, Met, Leu, 0.730, 0.706, 4.8 %, 0.680, 0.641; His, Arg, Lys, Ile, 0.730, 0.675, 0.7%, 0.662, 0.671; Ser, Gln, Ile, Phe, 0.730, 0.655, 2.8%, 0.664, 0.682; Ser, His, Ile, Phe, 0.730, 0.671, 1.1%, 0.658, 0.627; Gln, Ala, Met, Ile, 0.730, 0.689, 1.8%, 0.699, 0.706; Arg, Tyr, Orn, Leu, 0.730, 0.701, 2.9%, 0.679, 0.679 Asn, Ala, Cit, Ile, 0.730, 0.690, 2.0%, 0.704, 0.692; Asn, Ala, Tyr, Ile, 0.730, 0.718, 8.8%, 0.709, 0.675; Asn, Cit, Val, Lys, 0.730, 0.676 , 0.7%, 0.646, 0.604; Asn, Gln, Met, Ile, 0.730, 0.692, 2.2%, 0.701, 0.688; Asn, Val, Ile, Leu, 0.730, 0.686, 0.6%, 0.678, 0.609; Orn, Le u, 0.730, 0.670, 1.1%, 0.662, 0.633; Gln, Arg, Orn, Ile, 0.730, 0.679, 2.6%, 0.694, 0.680; Gln, Tyr, Val, Lys, 0.730, 0.719, 4.8%, 0.698, 0.72 His, Arg, Tyr, Lys, 0.730, 0.703, 1.7%, 0.700, 0.779; Ser, Gln, Ile, Leu, 0.730, 0.669, 1.5%, 0.663, 0.684; Ser, Gln, Val, Ile, 0.730, 0.669 Ser, Tyr, Ile, Phe, 0.730, 0.705, 6.6%, 0.695, 0.647; Thr, Arg, Tyr, Ile, 0.730, 0.717, 8.6%, 0.727, 0.712; Asn, Arg, Tyr, Lys, 0.729, 0.709, 5.3%, 0.694, 0.734; Asn, Gly, Cit, Ile, 0.729, 0.682, 1.1%, 0.681, 0.645; Asn, Orn, Leu, Phe, 0.729, 0.663, 0.6%, 0.639 Asn, Thr, Tyr, Leu, 0.729, 0.720, 4.0%, 0.710, 0.659; Gln, Ala, Ile, Trp, 0.729, 0.687, 1.5%, 0.699, 0.698; Gln, Ala, Orn, Ile, 0.729 , 0.679, 2.0%, 0.687, 0.692; Gln, Ala, Val, Leu, 0.729, 0.681, 0.2%, 0.678, 0.637; Gln, Arg, Val, Ile, 0.729, 0.696, 0.6%, 0.703, 0.673; Pro, Ile, Trp, 0.729, 0.689, 1.1%, 0.697, 0.688; Gly, Gln, Ala, Ile, 0.729, 0.680, 1.3%, 0.684, 0.694; Gly, Gln, Met, Ile, 0.729, 0.684, 1.8% , 0.690 , 0.702; Gly, Gln, Thr, Ile, 0.729, 0.675, 1.3%, 0.680, 0.702; Gly, Tyr, Ile, Phe, 0.729, 0.703, 6.6%, 0.689, 0.643; His, Met, Lys, Ile, 0.729 , 0.672, 2.0%, 0.640, 0.594; His, Thr, Ile, Phe, 0.729, 0.678, 0.7%, 0.667, 0.602; His, Tyr, Ile, T

rp, 0.729, 0.706, 7.2%, 0.695, 0.686; Ser, Gln, His, Leu, 0.729, 0.689, 0.2%, 0.682, 0.663; Ser, Gln, Leu, Trp, 0.729, 0.668, 0.4%, 0.649, 0.631 Ser, Gln, Orn, Ile, 0.729, 0.659, 2.8%, 0.665, 0.716; Ser, Gln, Thr, Ile, 0.729, 0.662, 2.6%, 0.667, 0.716; Ser, Tyr, Met, Ile, 0.729, 0.710 , 6.6%, 0.703, 0.704; Arg, Pro, Tyr, Ile, 0.728, 0.715, 5.7%, 0.724, 0.712; Arg, Tyr, Ile, Leu, 0.728, 0.710, 3.3%, 0.712, 0.690; Orn, Ile, 0.728, 0.714, 5.7%, 0.722, 0.710; Asn, Ala, Ile, Trp, 0.728, 0.686, 1.8%, 0.691, 0.671; Asn, Arg, Lys, Leu, 0.728, 0.664, 0.4%, 0.636 Asn, Cit, Lys, Leu, 0.728, 0.668, 0.4%, 0.636, 0.572; Asn, Cit, Val, Ile, 0.728, 0.695, 0.7%, 0.694, 0.659; Asn, His, Leu, Phe, 0.728 , 0.682, 0.2%, 0.667, 0.566; Asn, Ile, Leu, Trp, 0.728, 0.686, 0.6%, 0.679, 0.611; Asn, Pro, Leu, Phe, 0.728, 0.677, 0.6%, 0.662, 0.572; Pro, Tyr, Leu, 0.728, 0.713, 2.6%, 0.700, 0.649; Asn, Thr, Ile, Leu, 0.728, 0.684, 0.6%, 0.673, 0.617; Gln, Arg, Pro, Ile, 0.728, 0.692, 1.1% , 0.70 5, 0.692; Gln, His, Pro, Lys, 0.728, 0.683, 2.9%, 0.688, 0.724; Gln, His, Tyr, Met, 0.728, 0.730, 1.5%, 0.751, 0.753; 0.728, 0.728, 5.7%, 0.716, 0.692; Gly, Arg, Tyr, Leu, 0.728, 0.703, 2.4%, 0.691, 0.663; Gly, Gln, Arg, Ile, 0.728, 0.679, 1.3%, 0.687, 0.679; , Gln, His, Tyr, 0.728, 0.724, 1.7%, 0.739, 0.755; Gly, Gln, Ile, Trp, 0.728, 0.680, 0.9%, 0.682, 0.682; Gly, Gln, Leu, Trp, 0.728, 0.676, 0.2 %, 0.650, 0.606; His, Ala, Met, Ile, 0.728, 0.682, 1.7%, 0.674, 0.631; His, Pro, Ile, Phe, 0.728, 0.675, 1.1%, 0.664, 0.617; Ile, 0.728, 0.663, 2.6%, 0.669, 0.718; Ser, Gln, Val, Lys, 0.728, 0.681, 0.9%, 0.645, 0.639; Thr, Tyr, Val, Phe, 0.728, 0.729, 7.5%, 0.712, 0.673 Tyr, Met, Orn, Ile, 0.728, 0.725, 6.6%, 0.716, 0.700; Tyr, Val, Met, Phe, 0.728, 0.722, 7.0%, 0.698, 0.669; Arg, Tyr, Ile, Trp, 0.728, 0.716 , 6.6%, 0.718, 0.704; Asn, Arg, Ile, Leu, 0.728, 0.687, 0.7%, 0.686, 0.617; Asn, Thr, Ile, Phe, 0.728, 0.673, 1.7%, 0.672, 0.623; Val, Orn Asn, Val, Leu, Phe, 0.728, 0.674, 0.4%, 0.652, 0.558; Gln, His, Val, Lys, 0.728, 0.692, 0.9%, 0.668, 0.669; Gln, Met, Ile, Trp, 0.728, 0.688, 1.3%, 0.696, 0.708; Gln, Met, Leu, Phe, 0.728, 0.681, 0.0%, 0.670, 0.627; Gln, Met, Orn, Ile, 0.728, 0.682, 1.8%, 0.693, 0.700; Gln, Thr, Orn, Ile, 0.728, 0.678, 1.7%, 0.685, 0.708; Gln, Thr, Val, Lys, 0.728, 0.683, 0.6%, 0.647, 0.639; Gly, Tyr, Leu, Phe, 0.728, 0.700, 2.2%, 0.676, 0.606; His, Arg, Met, Ile, 0.728, 0.686, 0.6%, 0.687, His, Met, Ile, Phe, 0.728, 0.673, 0.9%, 0.661, 0.584; His, Tyr, Lys, Ile, 0.728, 0.697, 6.6%, 0.680, 0.710; Ser, Gln, Ile, Trp, 0.728, Ser, Gly, Gln, Ile, 0.728, 0.662, 2.8%, 0.665, 0.714; Ala, Arg, Tyr, Lys, 0.727, 0.696, 3.7%, 0.682, 0.777; Ala, Cit Asn, Gln, His, Leu, 0.727, 0.700, 0.0%, 0.702, 0.643; Asn, Gln, His, Val, 0.727, 0.700, 0.2%, 0.700, Asn, Thr, Cit, Ile, 0.727, 0.686, 1.1%, 0.689, 0.661; Asn, Thr, Tyr, Ile, 0.727, 0.719, 9.7%, 0.715, 0.680; Gln, Ala, Pro, Leu, 0.727, 0.684, 0.4%, 0.677, 0.637; Gln, His, Orn, Lys, 0.727, 0.667, 1.3%, 0.660, 0.720; Gln, Pro, Leu, Phe, 0.727, 0.684, 0.2%, 0.678, 0.602; Gln, Thr, Ala, Ile, 0.727, 0.682, 2.2%, 0.692, 0.706; Gln, Tyr, Val, Orn, 0.727, 0.717, 7.0%, 0.704, 0.710; Gly, Gln, His, Leu, 0.727, 0.691, 0.4%, 0.680, 0.647; Gly, Gln, Met, Leu, 0.727, 0.679, 0.2%, 0.657, 0.625; Ser, Asn, Tyr, Val, 0.727, 0.724, 7.7%, 0.705, 0.663; Ser, Thr, Tyr, Ile, 0.727, 0.700, 11.2%, 0.698, 0.712; , Tyr, Leu, Phe, 0.727, 0.714, 2.0%, 0.699, 0.633; Tyr, Met, Lys, Leu, 0.727, 0.713, 4.0%, 0.686, 0.669; %, 0.674, 0.633; Asn, Arg, Val, Lys, 0.726, 0.674, 1.1%, 0.653, 0.623; Asn, Gln, His, Lys, 0.726, 0.674, 1.8%, 0.669, 0.692; Leu, Asn, His, Pro, Val, 0.726, 0.693, 0.2%, 0.682, 0.604; Asn, His, Val, Met, 0.726, 0.693, 0.0%, 0.680, 0.613; Asn, Tyr, Ile, Trp, 0.726, 0.714, 9.0%, 0.706, 0.671; Asn, Tyr, Val, Trp, 0.726, 0.725, 7.7 %, 0.699, 0.671; Asn, Val, Lys, Trp, 0.726, 0.671, 1.5%, 0.638, 0.602; Gln, Cit, Orn, Leu, 0.726, 0.666, 0.2%, 0.650, 0.621; Trp, 0.726, 0.686, 0.2%, 0.672, 0.637; Gln, Thr, Met, Ile, 0.726, 0.684, 1.7%, 0.693, 0.710; Gly, Gln, Thr, Leu, 0.726, 0.678, 0.2%, 0.615, 0.615 Gly, Gln, Val, Lys, 0.726, 0.680, 0.6%, 0.641, 0.625; Met, Lys, Ile, Phe, 0.726, 0.665, 1.3%, 0.628, 0.625; Orn, Lys, Ile, Phe, 0.726, 0.674 Ser, Asn, Orn, Leu, 0.726, 0.658, 0.7%, 0.631, 0.558; Ser, Met, 0.726, 0.658, 0.7%, 0.631, 0.558; Lys, Ile, 0.726, 0.651, 3.3%, 0.616, 0.657; Tyr, Orn, Ile, Trp, 0.726, 0.718, 8.5%, 0.705, 0.702; Tyr, Val, Ile, Trp, 0.726, 0.715, 8.6%, 0.691 , Val, Lys, Ile, Phe, 0.726, 0.666, 1.7%, 0.629, 0.623; Ala, Arg, Tyr, Ile, 0.726, 0.715, 5.5%, 0.722, 0.708; Arg, Tyr, Lys, Phe, 0.726, 0.700, 3.5%, 0.691, 0.761; Asn, Cit, Ile, Trp, 0.726, 0.690, 0.7%, 0.697, 0.659; Asn, Gly, Leu, Phe, 0.726, 0.669, 0.4%, 0.641, 0.531; Asn, Gly, Orn, Leu, 0.726, 0.662, 0.7%, 0.632, 0.546; Asn, Met, Leu, Phe, 0.726, 0.675, 0.2%, Gln, Arg, Val, Lys, 0.726, 0.680, 0.9%, 0.653, 0.649; Gln, His, Thr, Leu, 0.726, 0.695, 0.2%, 0.690, 0.659; Gln, Pro, Orn, Leu, His, Cit, Met, Ile, 0.726, 0.687, 1.7%, 0.678, 0.633; Ser, Gln, Ala, Leu, 0.726, 0.664, 0.2%, 0.660, 0.647; Ser, Gly, Gln, Leu, 0.726, 0.667, 0.2%, 0.644, 0.617; Tyr, Val, Leu, Phe, 0.726, 0.708, 2.4 %, 0.690, 0.633; Tyr, Val, Met, Leu, 0.726, 0.717, 5.3%, 0.699, 0.675; Arg, Tyr, Leu, Trp, 0.725, 0.713, 4.6%, 0.698, 0.665; Lys, 0 .725, 0.663, 1.8%, 0.644, 0.637; Asn, Cit, Arg, Ile, 0.725, 0.688, 0.6%, 0.695, 0.659; Asn, Cit, Pro, Ile, 0.725, 0.687, 1.1%, 0.689, 0.651; Asn, Gln, Pro, Leu, 0.725, 0.690, 0.4%, 0.682, 0.613; Asn, Gly, Cit, Leu, 0.725, 0.670, 0.4%, 0.638, 0.554; Cit, Lys, Ile, Trp, 0.725, 0.676, 1.7%, 0.655, 0.688; Cit, Tyr, Val, Orn, 0.725, 0.701, 5.7%, 0.689, 0.702; Gln, Ala, Arg, Ile, 0.725, 0.689, 1.8%, 0.705, 0.704; Gln, Ala, Val, Ile, 0.725, 0.691, 1.1%, 0.697, 0.682; Gln, Arg, Leu, Trp, 0.725, 0.683, 0.2%, 0.673, Gln, Arg, Lys, Leu, 0.725, 0.671, 0.2%, 0.648, 0.653; Gln, Pro, Leu, Trp, 0.725, 0.688, 0.2%, 0.678, 0.625; Gln, Thr, Ile, Trp, 0.725, 0.682, 1.5%, 0.688, 0.704; Gln, Thr, Tyr, Val, 0.725, 0.728, 9.0%, 0.718, 0.716; Gln, Val, Lys, Trp, 0.725, 0.681, 0.6%, 0.646, 0.639; His, Arg, Orn, Ile, 0.725, 0.672, 1.1%, 0.679, 0.639; His, Thr, Tyr, Ile, 0.725, 0.710, 7.2%, 0.719, 0. Ser, Gln, Pro, Leu, 0.725, 0.675, 0.6%, 0.662, 0.641; Thr, Tyr, Orn, Ile, 0.725, 0.720, 9.6%, 0.719, 0.710; Val, Ile, Leu, Phe, 0.725, Val, Met, Lys, Ile, 0.725, 0.672, 2.6%, 0.635, 0.651; Ala, Ile, Leu, Phe, 0.724, 0.673, 0.4%, 0.658, 0.609; Asn, Ala Asn, Arg, Orn, Leu, 0.724, 0.664, 0.4%, 0.649, 0.574; Asn, Cit, Met, Ile, 0.724, 0.690, 1.5%, Asn, Gln, His, Pro, 0.724, 0.691, 2.0%, 0.735, 0.712; Asn, Gly, His, Val, 0.724, 0.693, 0.2%, 0.682, 0.611; Asn, Gly, Thr, Leu, 0.724, 0.670, 0.6%, 0.642, 0.560; Asn, Pro, Ile, Leu, 0.724, 0.683, 0.6%, 0.672, 0.611; Cit, Met, Lys, Ile, 0.724, 0.674, 1.1%, 0.654, 0.679; , Orn, Lys, Ile, 0.724, 0.665, 2.4%, 0.643, 0.661; Cit, Tyr, Leu, Trp, 0.724, 0.709, 3.5%, 0.685, 0.671; Cit, Tyr, Lys, Leu, 0.724, 0.699, 1.8 %, 0.688, 0.684; Cit, Tyr, Orn, Leu, 0.724, 0.686, 2.4%, 0.680, 0.669; Gln, Arg, Met, Ile, 0.724, 0.691, 1.7%, 0.711, 0.722; Lys, 0.7 24, 0.677, 0.9%, 0.643, 0.639; Gly, Gln, Pro, Leu, 0.724, 0.683, 0.2%, 0.667, 0.617; Pro, Tyr, Val, Met, 0.724, 0.721, 8.1%, 0.697, 0.669; Thr, Tyr, Ile, Trp, 0.724, 0.713, 11.4 %, 0.708, 0.696; Tyr, Orn, Lys, Ile, 0.724, 0.709, 7.5%, 0.687, 0.718; Arg, Orn, Leu, Phe, 0.724, 0.655, 0.2%, 0.638, 0.550; Val, 0.724, 0.721, 7.0%, 0.698, 0.661; Asn, Arg, Pro, Leu, 0.724, 0.682, 0.6%, 0.674, 0.602; Asn, Arg, Val, Ile, 0.724, 0.690, 1.8%, 0.692, 0.647 Asn, Cit, Tyr, Val, 0.724, 0.723, 4.8%, 0.710, 0.692; Asn, Gln, Cit, Leu, 0.724, 0.685, 0.2%, 0.674, 0.613; Asn, Tyr, Val, Phe, 0.724, 0.722 , 5.9%, 0.697, 0.667; Cit, Arg, Ile, Phe, 0.724, 0.683, 0.9%, 0.689, 0.635; Gln, Ala, Pro, Ile, 0.724, 0.685, 1.5%, 0.695, 0.698; Arg, Pro, 0.724, 0.690, 1.3%, 0.737, 0.704; Gln, His, Cit, Lys, 0.724, 0.672, 1.5%, 0.673, 0.724; Gln, His, Leu, Trp, 0.724, 0.696, 0.4%, 0.691 , 0.6 59; Gln, His, Lys, Phe, 0.724, 0.673, 1.5%, 0.676, 0.728; Gln, His, Met, Lys, 0.724, 0.672, 1.5%, 0.674, 0.724; 0.691, 2.2%, 0.735, 0.722; Gly, Gln, His, Pro, 0.724, 0.691, 2.4%, 0.733, 0.718; Gly, Ile, Leu, Phe, 0.724, 0.668, 0.6%, 0.651, 0.582; His, Arg, Ile, Trp, 0.724, 0.685, 1.8%, 0.688, 0.639; His, Cit, Orn, Ile, 0.724, 0.666, 2.8%, Ile, Leu, Phe, Trp, 0.724, 0.673, 0.6%, 0.659, 0.586; Ser, Asn, His, Val, 0.724, 0.693, 0.2%, 0.682, 0.604; Ser, Gln, Thr, Leu, 0.724, 0.669, 0.2%, 0.654, 0.641; Ser, His, Tyr, Ile, 0.724, 0.700, 5.5%, 0.692, 0.700; Tyr , Met, Leu, Trp, 0.724, 0.715, 6.1%, 0.690, 0.659; Val, Lys, Leu, Phe, 0.724, 0.664, 0.4%, 0.622, 0.580; %, 0.630, 0.679; Ala, Tyr, Met, Leu, 0.723, 0.709, 5.1%, 0.695, 0.669; Arg, Tyr, Met, Lys, 0.723, 0.700, 5.1%, 0.687, 0.757; Asn, Ala, Arg, Ile, 0.72 3, 0.682, 2.0%, 0.695, 0.667; Asn, His, Ala, Val, 0.723, 0.688, 0.9%, 0.675, 0.627; Asn, His, Orn, Leu, 0.723, 0.669, 0.4%, 0.652, 0.556; , Met, Ile, Trp, 0.723, 0.683, 2.2%, 0.686, 0.647; Asn, Pro, Ile, Trp, 0.723, 0.681, 2.2%, 0.686, 0.

649; Asn, Thr, Leu, Phe, 0.723, 0.670, 0.6%, 0.647, 0.548; Gln, Cit, Leu, Trp, 0.723, 0.681, 0.0%, 0.669, 0.621; 0.687, 0.2%, 0.679, 0.627; Gln, Pro, Tyr, Val, 0.723, 0.721, 6.8%, 0.705, 0.712; Gly, Met, Lys, Ile, 0.723, 0.666, 2.6%, 0.632, 0.663; , Ile, Trp, 0.723, 0.704, 9.2%, 0.687, 0.686; Gly, Tyr, Val, Met, 0.723, 0.719, 9.2%, 0.689, 0.669; Met, Orn, Lys, Ile, 0.723, 0.673, 1.8%, Pro, Ile, Leu, Phe, 0.723, 0.670, 0.4%, 0.650, 0.572; Pro, Tyr, Met, Leu, 0.723, 0.712, 6.4%, 0.698, 0.657; Ser, Asn, Ala, Leu, Ser, Gln, Ala, Ile, 0.723, 0.657, 2.9%, 0.662, 0.718; Ser, Gln, His, Pro, 0.723, 0.691, 2.4%, 0.733, 0.718; Thr Ala, Cit, Lys, Ile, 0.723, 0.671, 3.5%, 0.652, 0.686; Arg, Tyr, Met, Leu, 0.723, 0.716, 2.4 %, 0.705, 0.673; Asn, Gln, Tyr, Lys, 0.723, 0.719, 7.9%, 0.697, 0.734; Asn, His, Val, Orn, 0.723, 0.685, 0.0%, 0.671, 0.606; Lys, 0. 723, 0.660, 5.0%, 0.657, 0.682; Gln, His, Arg, Leu, 0.723, 0.694, 0.0%, 0.695, 0.659; Gln, His, Thr, Lys, 0.723, 0.672, 1.5%, 0.674, 0.722; , His, Thr, Pro, 0.723, 0.691, 2.2%, 0.733, 0.718; Gln, His, Val, Orn, 0.723, 0.692, 1.5%, 0.685, 0.667; %, 0.672, 0.720; Gly, Lys, Leu, Phe, 0.723, 0.657, 0.4%, 0.616, 0.560; His, Ala, Tyr, Ile, 0.723, 0.701, 5.9%, 0.691, 0.696; Lys, 0.723, 0.675, 1.5%, 0.638, 0.631; His, Pro, Tyr, Ile, 0.723, 0.702, 5.0%, 0.694, 0.704; Thr, Lys, Ile, Phe, 0.723, 0.665, 1.8%, 0.630, 0.629 Thr, Tyr, Met, Leu, 0.723, 0.714, 4.4%, 0.700, 0.669; Ala, Arg, Tyr, Leu, 0.722, 0.702, 1.8%, 0.703, 0.690; Asn, Ala, Arg, Leu, 0.722, 0.679 , 0.6%, 0.674, 0.629; Asn, Ala, Orn, Ile, 0.722, 0.682, 2.0%, 0.682, 0.667; Asn, Gly, His, Leu, 0.722, 0.678, 0.4%, 0.662, 0.570; Tyr, Leu, 0.722, 0.697, 3.1%, 0.693, 0.686; Cit, Val, Ile, Phe, 0.722, 0.687, 0.6%, 0.680, 0.639; Gln, Cit, Tyr, Val, 0.722, 0.724, 3.9%, 0.715 , 0.7 28; Gln, His, Lys, Trp, 0.722, 0.677, 0.7%, 0.677, 0.724; Gln, Met, Ile, Phe, 0.722, 0.682, 1.1%, 0.695, 0.682; Gly, Arg, Tyr, Val, 0.722, 0.713, 4.2%, 0.695, 0.682; Ser, Asn, Leu, Phe, 0.722, 0.660, 0.6%, 0.635, 0.544; Ser, Gln Ser, His, Met, Ile, 0.722, 0.667, 1.7%, 0.653, 0.619; Ser, Thr, Lys, Ile, 0.722, 0.645, 4.6%, Thr, Ala, Cit, Ile, 0.722, 0.687, 3.9%, 0.690, 0.700; Thr, Cit, Pro, Ile, 0.722, 0.685, 2.4%, 0.677, 0.659; Thr, Ile, Leu, Phe, Ala, Cit, Tyr, Leu, 0.721, 0.697, 2.6%, 0.693, 0.688; Arg, Tyr, Val, Phe, 0.721, 0.720, 5.0%, 0.713, 0.690; Asn Asn, Orn, Ile, Trp, 0.721, 0.677, 1.7%, 0.681, 0.649; Asn, Pro, Lys, Leu, 0.721, 0.669, 1.1 %, 0.632, 0.570; Gln, Ala, Cit, Leu, 0.721, 0.679, 0.2%, 0.677, 0.631; Gln, Arg, Tyr, Val, 0.721, 0.725, 4.0%, 0.714, 0.722; Leu, 0.72 Gln, Val, Met, Lys, 0.721, 0.683, 0.4%, 0.648, 0.651; Gly, Cit, Lys, Ile, 0.721, 0.673, 1.7%, 0.650, 0.671; His , Lys, Leu, Phe, 0.721, 0.658, 0.4%, 0.617, 0.564; His, Tyr, Orn, Ile, 0.721, 0.710, 4.4%, 0.701, 0.712; Met, Lys, Ile, Leu, 0.721, 0.668, 2.0 %, 0.633, 0.633; Orn, Ile, Leu, Phe, 0.721, 0.666, 0.7%, 0.650, 0.582; Ser, Cit, Lys, Ile, 0.721, 0.664, 2.8%, 0.640, 0.677; Leu, 0.721, 0.670, 0.2%, 0.653, 0.643; Ser, Gln, Val, Leu, 0.721, 0.672, 0.2%, 0.652, 0.637; Tyr, Val, Lys, Ile, 0.721, 0.699, 6.1%, 0.674, 0.684 Tyr, Val, Met, Lys, 0.721, 0.716, 6.8%, 0.680, 0.688; Val, Ile, Phe, Trp, 0.721, 0.681, 0.9%, 0.664, 0.609; Ala, Met, Ile, Leu, 0.721, 0.679 , 1.7%, 0.665, 0.633; Asn, Arg, Ile, Trp, 0.721, 0.683, 1.7%, 0.694, 0.643; Asn, Gly, Met, Leu, 0.721, 0.673, 0.6%, 0.644, 0.562; Pro, Leu, 0.721, 0.673, 0.6%, 0.648, 0.564; Asn, His, Ala, Leu, 0.721, 0.681, 0.2%, 0.672, 0.621; Asn, His, Cit, Leu, 0.721, 0.680, 0.2%, 0.669 , 0.596 Asn, His, Cit, Val, 0.721, 0.694, 0.4%, 0.682, 0.619; Asn, His, Pro, Leu, 0.721, 0.686, 0.4%, 0.674, 0.592; Asn, His, Thr, Val, 0.721, 0.691 , 0.2%, 0.678, 0.602; Asn, Met, Orn, Leu, 0.721, 0.666, 0.7%, 0.642, 0.564; Asn, Thr, Ile, Trp, 0.721, 0.679, 2.0%, 0.680, 0.645; Met, Ile, 0.721, 0.679, 2.2%, 0.676, 0.645; Asn, Val, Ile, Phe, 0.721, 0.681, 1.5%, 0.676, 0.623; Cit, Lys, Ile, Leu, 0.721, 0.677, 1.1%, 0.655 , 0.663; Cit, Pro, Tyr, Val, 0.721, 0.713, 5.5%, 0.700, 0.714; Gln, His, Ala, Val, 0.721, 0.695, 0.7%, 0.694, 0.673; Gly, Cit, Pro, Ile, 0.721, 0.681, 2.0%, 0.670, 0.647; Gln, Pro, Val, Leu, 0.721, 0.687, 0.2%, 0.679, 0.627; His, Tyr, Ile, 0.721, 0.700, 5.5%, 0.692, 0.698; His, Cit, Arg, Ile, 0.721, 0.688, 0.9%, 0.688, 0.657; His, Lys, Ile, Trp, 0.721, 0.672, 2.8% , 0.637, 0.627; Met, Lys, Ile, Trp, 0.721, 0.665, 2.6%, 0.630, 0.659; Thr, Arg, Tyr, Leu, 0.721, 0.710, 3.5%, 0.707, 0.677; Tyr, Lys, Ile, Trp , 0.721, Tyr, Val, Met, Trp, 0.721, 0.721, 9.4%, 0.694, 0.675; Ala, Cit, Orn, Ile, 0.720, 0.670, 2.9%, 0.671, 0.688; Ala, Cit Ala, Tyr, Val, Ile, 0.720, 0.708, 6.4%, 0.690, 0.682; Arg, Val, Lys, Phe, 0.720, 0.666, 0.9%, Asn, Ala, Leu, Phe, 0.720, 0.672, 0.2%, 0.658, 0.596; Asn, Cit, Leu, Phe, 0.720, 0.671, 0.2%, 0.650, 0.552; Asn, Cit, Orn, Leu, 0.720, 0.662, 0.4%, 0.640, 0.572; Asn, Gly, Ile, Phe, 0.720, 0.672, 1.5%, 0.670, 0.617; Asn, Gly, Thr, Ile, 0.720, 0.675, 2.4%, 0.671, Asn; , Leu, Phe, Trp, 0.720, 0.672, 0.2%, 0.652, 0.546; Asn, Met, Ile, Phe, 0.720, 0.677, 0.9%, 0.678, 0.609; Asn, Pro, Orn, Leu, 0.720, 0.669, 0.6 %, 0.648, 0.572; Asn, Val, Orn, Leu, 0.720, 0.668, 0.7%, 0.644, 0.558; Cit, Arg, Pro, Ile, 0.720, 0.684, 1.5%, 0.686, 0.655; Trp, 0.720, 0.681, 0.6%, 0.667, 0.633; Cit, Met, Ile, Phe, 0.720, 0.679, 0.7%, 0.677, 0.633; Cit, Tyr, Val, Met, 0.720, 0.723, 6.6%, 0.706, 0.704 ; Gln, Ala, Leu, Phe, 0.720, 0.669, 0.0%, 0.665, 0.609; Gln, Ala, Tyr, Val, 0.720, 0.720, 7.0%, 0.703, 0.710; Gln, Cit, Arg, Leu, 0.720, 0.678, 0.2%, 0.665, 0.627; Gln, Pro, Tyr, Lys, 0.720, 0.708, 8.6%, 0.692, 0.751; Gln, Thr, Pro, Leu, 0.720, 0.687, 0.4%, 0.676, 0.631; , Leu, 0.720, 0.683, 0.2%, 0.667, 0.631; Gln, Val, Leu, Trp, 0.720, 0.685, 0.0%, 0.673, 0.621; 0.677; Gly, Cit, Ile, Leu, 0.720, 0.676, 0.7%, 0.659, 0.623; Gly, Cit, Ile, Phe, 0.720, 0.675, 0.7%, 0.672, 0.637; 0.694, 2.6%, 0.678, 0.667; Gly, Cit, Val, Ile, 0.720, 0.684, 1.3%, 0.669, 0.639; Gly, His, Arg, Ile, 0.720, 0.682, 1.1%, 0.683, 0.643; His, Arg, Tyr, Val, 0.720, 0.719, 2.9%, 0.709, 0.696; His, Arg, Val, Lys, 0.720, 0.673, 0.7%, His, Cit, Ile, Trp, 0.720, 0.684, 2.4%, 0.672, 0.635; His, Met, Ile, Leu, 0.720, 0.679, 2.0%, 0.664, 0.594; His, Tyr, Val, Ile, 0.720, Ser, Arg, Tyr, Leu, 0.720, 0.705, 2.2%, 0.698, 0.682; Ser, Asn, Ala, Ile, 0.720, 0.655, 3.3%, 0.653, 0.679; Ser, Asn Ser, Asn, Met, Leu, 0.720, 0.662, 0.7%, 0.637, 0.568; Ser, Gln, Cit, Leu, 0.720, 0.667, 0.2%, Ser, Tyr, Met, Leu, 0.720, 0.712, 4.8%, 0.696, 0.663; Ser, Tyr, Orn, Ile, 0.720, 0.710, 7.2%, 0.701, 0.714; Thr, Tyr, Lys, Ile, 0.720, 0.701, 9.7%, 0.687, 0.716; Thr, Tyr, Val, Ile, 0.720, 0.719, 9.7%, 0.709, 0.686
［９．アミノ酸を含む５変数の式］
Arg, Tyr, Lys, Ile, Phe, 0.776, 0.721, 2.9%, 0.723, 0.726; Gln, His, Tyr, Ile, Phe, 0.774, 0.735, 2.2%, 0.756, 0.734; Gln, Tyr, Lys, Ile, Phe, 0.771, 0.724, 5.5%, 0.719, 0.726; Asn, Arg, Tyr, Lys, Ile, 0.770, 0.717, 5.3%, 0.715, 0.730; Gln, His, Cit, Ile, Phe, 0.770, 0.712, 0.0%, 0.733, 0.692; Asn, Gln, His, Ile, Phe, 0.769, 0.709, 0.0%, 0.738, 0.673; Gln, His, Arg, Tyr, Ile, 0.769, 0.736, 2.4%, 0.762, 0.789; Ser, Gln, Tyr, Ile, Phe, 0.768, 0.720, 5.7%, 0.732, 0.716; Asn, Gln, Tyr, Leu, Phe, 0.768, 0.737, 2.2%, 0.737, 0.679; Gln, His, Tyr, Ile, Trp, 0.768, 0.740, 5.0%, 0.755, 0.759; Gln, Tyr, Ile, Leu, Phe, 0.768, 0.729, 2.9%, 0.734, 0.698; Asn, Gln, His, Cit, Ile, 0.767, 0.717, 0.7%, 0.742, 0.724; Asn, Gln, His, Tyr, Ile, 0.766, 0.737, 3.9%, 0.759, 0.761; Gln, His, Cit, Orn, Ile, 0.766, 0.697, 0.9%, 0.711, 0.720; Gln, His, Cit, Pro, Ile, 0.766, 0.712, 1.1%, 0.735, 0.736; Asn, Gln, His, Ala, Ile, 0.765, 0.712, 1.7%, 0.735, 0.712; Gln, Arg, Lys, Ile, Phe, 0.765, 0.684, 1.1%, 0.682, 0.692; Gln, His, Tyr, Orn, Ile, 0.765, 0.727, 2.4%, 0.750, 0.777; Gln, His, Tyr, Val, Ile, 0.765, 0.731, 2.4%, 0.753, 0.773; Gly, Gln, Tyr, Leu, Phe, 0.765, 0.723, 2.6%, 0.715, 0.682; Gln, His, Arg, Ile, Phe, 0.764, 0.707, 0.0%, 0.730, 0.679; Gln, His, Ile, Leu, Phe, 0.764, 0.709, 0.0%, 0.730, 0.682; Asn, Gly, Gln, Tyr, Ile, 0.764, 0.724, 6.8%, 0.727, 0.724; Asn, His, Cit, Tyr, Ile, 0.764, 0.728, 3.7%, 0.743, 0.732; Gln, His, Tyr, Met, Ile, 0.764, 0.741, 5.7%, 0.757, 0.748; Gln, Tyr, Met, Ile, Phe, 0.764, 0.730, 6.1%, 0.741, 0.704; Gly, Arg, Tyr, Lys, Ile, 0.764, 0.707, 3.9%, 0.704, 0.738; Gln, Arg, Lys, Ile, Trp, 0.763, 0.687, 0.9%, 0.682, 0.728; Gln, His, Cit, Tyr, Ile, 0.763, 0.736, 2.6%, 0.761, 0.797; Gln, His, Ile, Phe, Trp, 0.763, 0.708, 0.2%, 0.730, 0.688; Gln, His, Tyr, Ile, Leu, 0.763, 0.731, 2.4%, 0.753, 0.769; Gly, Gln, Tyr, Leu, Trp, 0.763, 0.727, 5.0%, 0.709, 0.700; Arg, Tyr, Met, Lys, Ile, 0.763, 0.721, 4.8%, 0.718, 0.742; Asn, Gln, Tyr, Ile, Phe, 0.763, 0.730, 6.2%, 0.742, 0.706; Asn, Gly, Cit, Tyr, Ile, 0.763, 0.724, 6.6%, 0.726, 0.716; Gln, His, Ala, Tyr, Ile, 0.763, 0.732, 2.6%, 0.753, 0.775; Gln, His, Pro, Tyr, Ile, 0.763, 0.732, 2.6%, 0.752, 0.777; Gln, Tyr, Leu, Phe, Trp, 0.763, 0.733, 2.6%, 0.728, 0.684; Gly, Gln, Tyr, Ile, Phe, 0.763, 0.719, 5.7%, 0.725, 0.708; Asn, Gln, His, Orn, Ile, 0.762, 0.698, 2.4%, 0.720, 0.696; Asn, Gln, His, Pro, Ile, 0.762, 0.711, 1.7%, 0.735, 0.720; Gln, Ala, Tyr, Ile, Phe, 0.762, 0.727, 6.1%, 0.738, 0.706; Gln, His, Ala, Cit, Ile, 0.762, 0.712, 0.9%, 0.735, 0.742; Gln, Thr, Tyr, Ile, Phe, 0.762, 0.730, 6.4%, 0.744, 0.708; Gln, Tyr, Ile, Phe, Trp, 0.762, 0.729, 6.6%, 0.739, 0.706; Asn, Arg, Lys, Ile, Phe, 0.761, 0.676, 2.0%, 0.670, 0.669; Asn, Cit, Tyr, Lys, Ile, 0.761, 0.712, 5.7%, 0.708, 0.728; Asn, Gln, His, Arg, Ile, 0.761, 0.714, 1.1%, 0.738, 0.722; Asn, Gly, Cit, Lys, Ile, 0.761, 0.682, 1.5%, 0.664, 0.671; Gln, Tyr, Val, Ile, Phe, 0.761, 0.731, 5.7%, 0.735, 0.700; Gly, Gln, His, Tyr, Leu, 0.761, 0.725, 2.2%, 0.721, 0.734; Ser, Gln, His, Tyr, Ile, 0.761, 0.726, 2.8%, 0.748, 0.773; Asn, Gln, Arg, Lys, Ile, 0.761, 0.681, 2.2%, 0.677, 0.702; Asn, Gln, His, Val, Ile, 0.761, 0.713, 1.3%, 0.740, 0.724; Asn, Gly, Gln, Lys, Ile, 0.761, 0.679, 2.0%, 0.653, 0.665; Gln, His, Thr, Tyr, Ile, 0.761, 0.736, 3.5%, 0.757, 0.775; Gln, His, Val, Ile, Phe, 0.761, 0.706, 0.0%, 0.728, 0.684; Gln, Pro, Tyr, Ile, Phe, 0.761, 0.729, 5.3%, 0.743, 0.708; Gly, Gln, Arg, Lys, Ile, 0.761, 0.679, 1.1%, 0.669, 0.702; His, Arg, Tyr, Ile, Phe, 0.761, 0.722, 3.3%, 0.733, 0.694; Ser, Arg, Tyr, Lys, Ile, 0.761, 0.707, 3.3%, 0.703, 0.753; Asn, Arg, Orn, Lys, Ile, 0.760, 0.666, 2.8%, 0.661, 0.669; Asn, Arg, Pro, Tyr, Lys, 0.760, 0.705, 6.8%, 0.690, 0.744; Asn, Gln, His, Ile, Leu, 0.760, 0.714, 1.1%, 0.735, 0.716; Gln, Arg, Orn, Lys, Ile, 0.760, 0.681, 1.1%, 0.678, 0.712; Gln, His, Cit, Ile, Trp, 0.760, 0.714, 0.9%, 0.730, 0.712; Gln, His, Tyr, Leu, Phe, 0.760, 0.734, 1.5%, 0.740, 0.712; Gln, Tyr, Orn, Ile, Phe, 0.760, 0.732, 5.7%, 0.742, 0.704; Gly, Gln, Tyr, Lys, Ile, 0.760, 0.713, 4.4%, 0.701, 0.740; His, Tyr, Met, Lys, Ile, 0.760, 0.724, 6.2%, 0.710, 0.708; Asn, Gln, His, Met, Ile, 0.759, 0.713, 0.9%, 0.735, 0.714; Asn, Gln, Lys, Ile, Phe, 0.759, 0.680, 1.3%, 0.659, 0.645; Asn, Gly, Arg, Lys, Ile, 0.759, 0.674, 2.0%, 0.658, 0.663; Asn, Gly, Gln, Lys, Leu, 0.759, 0.678, 0.2%, 0.641, 0.600; Gln, His, Cit, Arg, Ile, 0.759, 0.711, 0.7%, 0.734, 0.730; Gln, His, Cit, Ile, Leu, 0.759, 0.712, 0.7%, 0.737, 0.738; Gln, His, Met, Ile, Phe, 0.759, 0.707, 0.2%, 0.728, 0.686; Tyr, Met, Lys, Ile, Phe, 0.759, 0.718, 7.5%, 0.700, 0.682; Asn, Gln, His, Tyr, Leu, 0.759, 0.734, 1.1%, 0.738, 0.722; Asn, Gln, Lys, Leu, Phe, 0.759, 0.678, 0.0%, 0.648, 0.607; Gln, Arg, Val, Lys, Ile, 0.759, 0.684, 1.3%, 0.686, 0.742; Gln, Cit, Arg, Lys, Ile, 0.759, 0.686, 0.9%, 0.687, 0.730; Gln, His, Ala, Ile, Trp, 0.759, 0.710, 1.8%, 0.728, 0.718; Gln, His, Cit, Val, Ile, 0.759, 0.711, 0.7%, 0.736, 0.730; Gln, His, Tyr, Lys, Leu, 0.759, 0.724, 3.5%, 0.716, 0.736; Ser, Asn, Arg, Lys, Ile, 0.759, 0.659, 2.9%, 0.647, 0.682; Asn, Cit, Pro, Lys, Ile, 0.758, 0.680, 1.8%, 0.665, 0.686; Asn, Gln, His, Lys, Ile, 0.758, 0.698, 2.6%, 0.692, 0.684; Asn, Gly, Gln, His, Ile, 0.758, 0.704, 1.3%, 0.726, 0.698; Asn, Tyr, Met, Lys, Ile, 0.758, 0.715, 8.1%, 0.694, 0.696; Cit, Tyr, Lys, Ile, Trp, 0.758, 0.714, 5.7%, 0.703, 0.742; Gln, His, Ala, Met, Ile, 0.758, 0.708, 0.6%, 0.726, 0.718; Gln, His, Cit, Met, Ile, 0.758, 0.711, 0.7%, 0.732, 0.722; Gln, Tyr, Lys, Leu, Phe, 0.758, 0.723, 1.5%, 0.718, 0.700; Gln, Tyr, Orn, Leu, Phe, 0.758, 0.721, 2.0%, 0.723, 0.680; Gly, Gln, His, Ile, Phe, 0.758, 0.700, 0.2%, 0.722, 0.679; Gly, Gln, Tyr, Ile, Leu, 0.758, 0.722, 3.5%, 0.720, 0.724; His, Arg, Tyr, Lys, Ile, 0.758, 0.711, 2.8%, 0.712, 0.742; Ser, Gly, Gln, Tyr, Ile, 0.758, 0.714, 5.5%, 0.718, 0.740; Arg, Pro, Tyr, Lys, Ile, 0.757, 0.709, 4.8%, 0.708, 0.748; Gln, His, Ala, Ile, Phe, 0.757, 0.699, 0.4%, 0.715, 0.684; Ser, His, Tyr, Ile, Phe, 0.757, 0.715, 3.5%, 0.713, 0.684; Arg, Tyr, Lys, Ile, Trp, 0.757, 0.714, 7.4%, 0.702, 0.726; Asn, His, Lys, Ile, Phe, 0.757, 0.687, 1.7%, 0.667, 0.625; Gln, His, Tyr, Leu, Trp, 0.757, 0.734, 3.5%, 0.727, 0.714; Gln, His, Val, Met, Ile, 0.757, 0.710, 0.6%, 0.731, 0.724; Ser, Gln, Arg, Lys, Ile, 0.757, 0.668, 0.2%, 0.658, 0.722; Asn, Arg, Lys, Ile, Leu, 0.757, 0.675, 2.0%, 0.668, 0.679; Asn, Arg, Lys, Ile, Trp, 0.757, 0.674, 2.2%, 0.668, 0.684; Asn, Cit, Arg, Lys, Ile, 0.757, 0.675, 2.0%, 0.670, 0.692; Asn, Cit, Lys, Ile, Leu, 0.757, 0.682, 1.5%, 0.670, 0.675; Asn, Gln, His, Ile, Trp, 0.757, 0.709, 1.5%, 0.730, 0.710; Asn, Gly, Gln, Tyr, Leu, 0.757, 0.725, 3.7%, 0.715, 0.675; Asn, His, Arg, Tyr, Ile, 0.757, 0.727, 3.7%, 0.739, 0.720; Asn, His, Cit, Lys, Ile, 0.757, 0.694, 3.9%, 0.689, 0.671; Asn, Thr, Tyr, Leu, Phe, 0.757, 0.730, 3.1%, 0.725, 0.657; Cit, Arg, Tyr, Lys, Ile, 0.757, 0.713, 2.6%, 0.715, 0.748; Gln, His, Arg, Pro, Ile, 0.757, 0.708, 0.9%, 0.735, 0.730; Gln, His, Thr, Cit, Ile, 0.757, 0.710, 0.7%, 0.733, 0.744; Gln, Pro, Tyr, Leu, Phe, 0.757, 0.726, 2.2%, 0.725, 0.682; Gln, Thr, Arg, Lys, Ile, 0.757, 0.687, 1.1%, 0.685, 0.720; Gln, Thr, Tyr, Leu, Phe, 0.757, 0.732, 1.7%, 0.734, 0.680; Gln, Tyr, Ile, Leu, Trp, 0.757, 0.734, 5.9%, 0.728, 0.726; Gly, Gln, His, Cit, Ile, 0.757, 0.704, 0.9%, 0.719, 0.714; Gly, Gln, Tyr, Met, Ile, 0.757, 0.728, 5.5%, 0.724, 0.722; Arg, Tyr, Ile, Leu, Phe, 0.756, 0.720, 2.8%, 0.723, 0.679; Arg, Tyr, Orn, Lys, Ile, 0.756, 0.708, 4.2%, 0.708, 0.740; Asn, Cit, Orn, Lys, Ile, 0.756, 0.672, 2.0%, 0.660, 0.667; Asn, Cit, Tyr, Ile, Phe, 0.756, 0.726, 4.8%, 0.734, 0.684; Asn, Gln, Thr, Leu, Phe, 0.756, 0.683, 0.0%, 0.672, 0.613; Asn, Gln, Val, Lys, Ile, 0.756, 0.677, 1.7%, 0.657, 0.690; Gln, Cit, Ile, Leu, Phe, 0.756, 0.695, 0.2%, 0.703, 0.651; Gln, Cit, Tyr, Ile, Phe, 0.756, 0.729, 3.7%, 0.749, 0.728; Gln, His, Arg, Orn, Ile, 0.756, 0.696, 0.9%, 0.721, 0.710; Gln, His, Orn, Ile, Phe, 0.756, 0.692, 0.4%, 0.711, 0.675; Gln, Tyr, Met, Leu, Phe, 0.756, 0.730, 1.7%, 0.731, 0.675; Gln, Tyr, Met, Lys, Ile, 0.756, 0.724, 5.0%, 0.718, 0.746; His, Tyr, Met, Ile, Phe, 0.756, 0.726, 2.4%, 0.724, 0.673; Asn, Gln, Cit, Lys, Ile, 0.756, 0.685, 1.5%, 0.674, 0.690; Asn, Gln, His, Thr, Ile, 0.756, 0.710, 1.7%, 0.734, 0.726; Asn, Gln, Lys, Ile, Leu, 0.756, 0.682, 1.1%, 0.661, 0.671; Asn, Gln, Tyr, Ile, Leu, 0.756, 0.725, 3.5%, 0.729, 0.704; Asn, Gln, Tyr, Lys, Leu, 0.756, 0.727, 2.6%, 0.715, 0.712; Asn, Lys, Ile, Leu, Phe, 0.756, 0.680, 1.5%, 0.649, 0.629; Asn, Tyr, Lys, Leu, Phe, 0.756, 0.721, 1.8%, 0.700, 0.641; Gln, His, Lys, Ile, Phe, 0.756, 0.697, 0.6%, 0.695, 0.669; Gly, Gln, Lys, Ile, Phe, 0.756, 0.672, 0.7%, 0.642, 0.653; Arg, Tyr, Val, Lys, Ile, 0.755, 0.713, 3.5%, 0.709, 0.738; Asn, Arg, Val, Lys, Ile, 0.755, 0.670, 2.9%, 0.663, 0.686; Asn, Thr, Arg, Lys, Ile, 0.755, 0.675, 2.2%, 0.670, 0.686; Gln, His, Ala, Arg, Ile, 0.755, 0.707, 0.9%, 0.735, 0.730; Gln, His, Tyr, Lys, Ile, 0.755, 0.722, 3.3%, 0.729, 0.769; Gly, Gln, Cit, Tyr, Ile, 0.755, 0.719, 3.9%, 0.725, 0.736; Gly, Gln, Tyr, Lys, Leu, 0.755, 0.720, 3.5%, 0.700, 0.716; His, Thr, Tyr, Ile, Phe, 0.755, 0.724, 3.1%, 0.731, 0.677; His, Tyr, Ile, Leu, Phe, 0.755, 0.711, 2.6%, 0.702, 0.661; Ser, Asn, Gln, His, Ile, 0.755, 0.694, 0.4%, 0.715, 0.720; Thr, Arg, Tyr, Lys, Ile, 0.755, 0.715, 7.5%, 0.716, 0.748; Asn, Cit, Tyr, Orn, Ile, 0.754, 0.714, 4.4%, 0.726, 0.728; Asn, Gln, His, Orn, Leu, 0.754, 0.692, 0.9%, 0.692, 0.637; Asn, Gln, Ile, Leu, Phe, 0.754, 0.696, 0.0%, 0.700, 0.629; Asn, Gln, Tyr, Lys, Ile, 0.754, 0.718, 6.8%, 0.710, 0.712; Asn, His, Tyr, Ile, Leu, 0.754, 0.724, 5.3%, 0.722, 0.684; Asn, His, Tyr, Met, Ile, 0.754, 0.734, 4.2%, 0.740, 0.706; Asn, Thr, Lys, Ile, Leu, 0.754, 0.680, 1.7%, 0.655, 0.661; Gln, His, Arg, Lys, Ile, 0.754, 0.699, 0.7%, 0.709, 0.710; Gln, His, Arg, Val, Ile, 0.754, 0.709, 0.4%, 0.734, 0.726; Gln, His, Met, Ile, Leu, 0.754, 0.709, 0.6%, 0.727, 0.716; Gln, His, Thr, Ile, Phe, 0.754, 0.701, 0.4%, 0.721, 0.690; Gln, His, Tyr, Val, Trp, 0.754, 0.736, 4.6%, 0.728, 0.734; His, Ala, Tyr, Ile, Phe, 0.754, 0.705, 3.1%, 0.702, 0.680; His, Cit, Tyr, Met, Ile, 0.754, 0.727, 3.3%, 0.731, 0.732; His, Tyr, Met, Ile, Trp, 0.754, 0.727, 4.8%, 0.725, 0.696; Ser, Asn, Gln, Lys, Ile, 0.754, 0.

662, 2.6%, 0.637, 0.679; Ser, Gln, Tyr, Leu, Trp, 0.754, 0.723, 4.6%, 0.709, 0.712; Arg, Tyr, Lys, Ile, Leu, 0.754, 0.710, 3.3%, 0.705, 0.738; Asn, Gln, Ala, Lys, Ile, 0.754, 0.679, 2.0%, 0.663, 0.686; Asn, Gln, Orn, Lys, Ile, 0.754, 0.676, 2.0%, 0.654, 0.677; Asn, Gln, Orn, Lys, Leu, 0.754, 0.671, 0.2%, 0.642, 0.607; Asn, Gln, Thr, Lys, Leu, 0.754, 0.680, 0.2%, 0.650, 0.621; Asn, Gln, Tyr, Leu, Trp, 0.754, 0.731, 5.0%, 0.720, 0.698; Asn, His, Tyr, Ile, Phe, 0.754, 0.721, 3.1%, 0.728, 0.671; Asn, Thr, Cit, Lys, Ile, 0.754, 0.680, 1.8%, 0.669, 0.682; Asn, Tyr, Ile, Leu, Phe, 0.754, 0.724, 3.5%, 0.715, 0.663; Asn, Tyr, Met, Leu, Phe, 0.754, 0.728, 2.6%, 0.716, 0.645; Gln, Arg, Lys, Ile, Leu, 0.754, 0.686, 1.5%, 0.685, 0.732; Gln, Cit, Lys, Ile, Phe, 0.754, 0.681, 0.6%, 0.668, 0.673; Gln, Cit, Tyr, Orn, Ile, 0.754, 0.710, 3.3%, 0.728, 0.742; Gln, His, Ala, Tyr, Leu, 0.754, 0.725, 2.0%, 0.730, 0.750; Gln, His, Met, Ile, Trp, 0.754, 0.709, 1.1%, 0.725, 0.706; Gly, Gln, Ala, Tyr, Ile, 0.754, 0.727, 6.1%, 0.728, 0.734; Gly, Gln, His, Tyr, Ile, 0.754, 0.726, 3.1%, 0.742, 0.757; Gly, Gln, Tyr, Ile, Trp, 0.754, 0.722, 6.4%, 0.720, 0.728; His, Pro, Tyr, Ile, Phe, 0.754, 0.710, 3.7%, 0.705, 0.684; Ser, Gln, His, Ile, Phe, 0.754, 0.690, 0.4%, 0.707, 0.684; Ser, Gln, Tyr, Lys, Ile, 0.754, 0.708, 4.2%, 0.702, 0.759; Ala, Arg, Tyr, Lys, Ile, 0.753, 0.709, 3.9%, 0.707, 0.742; Asn, Arg, Met, Lys, Ile, 0.753, 0.674, 1.8%, 0.668, 0.686; Asn, Arg, Tyr, Lys, Leu, 0.753, 0.719, 3.3%, 0.710, 0.690; Asn, Cit, Val, Lys, Ile, 0.753, 0.681, 1.8%, 0.668, 0.682; Asn, Gln, Lys, Ile, Trp, 0.753, 0.679, 1.3%, 0.657, 0.677; Gln, Ala, Arg, Lys, Ile, 0.753, 0.685, 1.1%, 0.687, 0.726; Gln, Arg, Ile, Leu, Phe, 0.753, 0.698, 0.2%, 0.702, 0.639; Gln, Arg, Met, Lys, Ile, 0.753, 0.684, 1.3%, 0.682, 0.726; Gln, Arg, Tyr, Lys, Ile, 0.753, 0.722, 4.0%, 0.730, 0.775; Gln, Cit, Pro, Orn, Ile, 0.753, 0.682, 1.8%, 0.688, 0.679; Gln, Cit, Tyr, Leu, Phe, 0.753, 0.729, 1.7%, 0.732, 0.686; Gln, His, Pro, Ile, Phe, 0.753, 0.704, 0.4%, 0.724, 0.679; Gln, Lys, Ile, Leu, Phe, 0.753, 0.684, 0.6%, 0.660, 0.653; Gln, Lys, Ile, Leu, Trp, 0.753, 0.685, 0.7%, 0.658, 0.692; Gln, Tyr, Lys, Ile, Trp, 0.753, 0.719, 7.4%, 0.713, 0.753; Gln, Tyr, Orn, Leu, Trp, 0.753, 0.721, 4.6%, 0.709, 0.708; Gln, Tyr, Val, Leu, Phe, 0.753, 0.728, 1.8%, 0.728, 0.677; Gly, Gln, Arg, Tyr, Ile, 0.753, 0.724, 5.9%, 0.730, 0.730; Gly, Gln, Cit, Tyr, Leu, 0.753, 0.717, 2.4%, 0.708, 0.710; Gly, Gln, Pro, Tyr, Ile, 0.753, 0.721, 5.0%, 0.725, 0.736; His, Tyr, Lys, Ile, Phe, 0.753, 0.702, 4.0%, 0.690, 0.682; Thr, Tyr, Ile, Leu, Phe, 0.753, 0.724, 3.3%, 0.719, 0.675; Ala, Arg, Lys, Ile, Phe, 0.752, 0.667, 0.6%, 0.662, 0.677; Arg, Orn, Lys, Ile, Phe, 0.752, 0.667, 0.9%, 0.657, 0.661; Asn, Arg, Tyr, Leu, Phe, 0.752, 0.729, 1.5%, 0.724, 0.645; Asn, Gly, Arg, Tyr, Ile, 0.752, 0.722, 5.5%, 0.721, 0.692; Asn, His, Pro, Tyr, Ile, 0.752, 0.725, 3.9%, 0.732, 0.706; Gln, His, Arg, Ile, Leu, 0.752, 0.709, 0.6%, 0.733, 0.716; Gln, His, Arg, Ile, Trp, 0.752, 0.709, 1.1%, 0.728, 0.704; Gln, His, Pro, Ile, Leu, 0.752, 0.709, 1.3%, 0.727, 0.730; Gln, His, Pro, Met, Ile, 0.752, 0.708, 0.9%, 0.728, 0.714; Gln, His, Thr, Met, Ile, 0.752, 0.709, 0.4%, 0.728, 0.724; Gln, His, Tyr, Val, Leu, 0.752, 0.729, 2.2%, 0.729, 0.740; Gln, Thr, Tyr, Ile, Leu, 0.752, 0.729, 4.6%, 0.733, 0.734; Gly, Gln, Thr, Tyr, Ile, 0.752, 0.725, 6.8%, 0.729, 0.728; His, Cit, Tyr, Ile, Phe, 0.752, 0.714, 2.4%, 0.719, 0.704; Ser, Asn, Gln, Tyr, Ile, 0.752, 0.713, 5.0%, 0.720, 0.732; Ser, Asn, His, Tyr, Ile, 0.752, 0.716, 4.2%, 0.719, 0.702; Arg, Lys, Ile, Phe, Trp, 0.752, 0.671, 0.9%, 0.655, 0.669; Arg, Met, Lys, Ile, Phe, 0.752, 0.675, 0.7%, 0.662, 0.673; Asn, Ala, Cit, Lys, Ile, 0.752, 0.677, 1.8%, 0.666, 0.692; Asn, Cit, Lys, Ile, Phe, 0.752, 0.680, 1.8%, 0.661, 0.665; Asn, Cit, Tyr, Met, Ile, 0.752, 0.733, 5.1%, 0.736, 0.704; Asn, Gly, Gln, Orn, Leu, 0.752, 0.675, 0.2%, 0.657, 0.592; Asn, Gly, His, Tyr, Ile, 0.752, 0.717, 4.6%, 0.715, 0.688; Asn, Gly, Tyr, Leu, Phe, 0.752, 0.717, 3.1%, 0.697, 0.625; Asn, His, Met, Ile, Phe, 0.752, 0.691, 0.7%, 0.692, 0.609; Asn, His, Tyr, Lys, Ile, 0.752, 0.710, 6.4%, 0.700, 0.690; Cit, Tyr, Val, Orn, Ile, 0.752, 0.709, 5.5%, 0.713, 0.730; Gln, His, Ala, Pro, Ile, 0.752, 0.707, 1.1%, 0.728, 0.734; Gln, His, Ala, Val, Ile, 0.752, 0.707, 1.1%, 0.728, 0.736; Gln, His, Met, Orn, Ile, 0.752, 0.696, 1.1%, 0.713, 0.696; Gln, His, Val, Ile, Leu, 0.752, 0.709, 0.9%, 0.729, 0.726; Gln, Orn, Ile, Leu, Phe, 0.752, 0.687, 0.2%, 0.685, 0.637; Gln, Tyr, Val, Lys, Trp, 0.752, 0.729, 6.6%, 0.707, 0.730; Gln, Val, Lys, Ile, Phe, 0.752, 0.674, 0.7%, 0.652, 0.671; Gly, Cit, Tyr, Val, Ile, 0.752, 0.714, 5.3%, 0.704, 0.720; Gly, Gln, Ala, Cit, Ile, 0.752, 0.687, 1.1%, 0.694, 0.690; Gly, Gln, Tyr, Orn, Ile, 0.752, 0.724, 5.3%, 0.723, 0.728; Gly, His, Tyr, Ile, Phe, 0.752, 0.707, 3.7%, 0.699, 0.675; Ser, Asn, Cit, Tyr, Ile, 0.752, 0.721, 4.6%, 0.727, 0.722; Ser, Gln, His, Cit, Ile, 0.752, 0.692, 1.1%, 0.710, 0.738; Ser, Gln, Tyr, Ile, Trp, 0.752, 0.713, 7.0%, 0.711, 0.746; Ser, Gln, Tyr, Leu, Phe, 0.752, 0.729, 1.8%, 0.728, 0.677; Thr, Arg, Lys, Ile, Phe, 0.752, 0.673, 0.9%, 0.659, 0.671; Asn, Gly, Ala, Tyr, Leu, 0.751, 0.713, 2.4%, 0.696, 0.647; Asn, Gly, Cit, Tyr, Leu, 0.751, 0.719, 3.1%, 0.704, 0.659; Cit, Tyr, Ile, Leu, Phe, 0.751, 0.712, 3.1%, 0.712, 0.673; Gln, Arg, Tyr, Ile, Phe, 0.751, 0.725, 3.9%, 0.740, 0.708; Gln, Arg, Tyr, Leu, Phe, 0.751, 0.732, 1.5%, 0.737, 0.694; Gln, Cit, Lys, Ile, Trp, 0.751, 0.686, 0.6%, 0.674, 0.714; Gln, His, Arg, Met, Ile, 0.751, 0.710, 0.4%, 0.731, 0.704; Gln, His, Pro, Tyr, Leu, 0.751, 0.726, 2.8%, 0.733, 0.748; Gln, His, Thr, Arg, Ile, 0.751, 0.707, 0.7%, 0.731, 0.730; Gln, His, Tyr, Met, Leu, 0.751, 0.735, 2.0%, 0.736, 0.724; Gln, Ile, Leu, Phe, Trp, 0.751, 0.695, 0.2%, 0.698, 0.639; Gln, Orn, Lys, Ile, Phe, 0.751, 0.677, 0.6%, 0.654, 0.665; Gln, Thr, Lys, Ile, Phe, 0.751, 0.678, 0.7%, 0.652, 0.661; Gly, Cit, Tyr, Met, Ile, 0.751, 0.717, 7.2%, 0.707, 0.702; Gly, Gln, Ala, Tyr, Leu, 0.751, 0.718, 2.8%, 0.708, 0.708; Gly, Gln, Cit, Lys, Ile, 0.751, 0.679, 0.7%, 0.662, 0.710; Gly, Gln, His, Ala, Ile, 0.751, 0.701, 1.1%, 0.716, 0.720; Gly, Gln, Lys, Ile, Trp, 0.751, 0.676, 0.7%, 0.644, 0.688; Gly, Gln, Thr, Lys, Ile, 0.751, 0.677, 0.7%, 0.650, 0.696; Gly, Gln, Tyr, Orn, Leu, 0.751, 0.718, 2.8%, 0.707, 0.702; Ser, Gln, His, Arg, Ile, 0.751, 0.691, 0.6%, 0.708, 0.740; Ser, His, Tyr, Met, Ile, 0.751, 0.721, 5.5%, 0.723, 0.716; Asn, Arg, Pro, Lys, Ile, 0.750, 0.671, 2.9%, 0.661, 0.669; Asn, Gln, Cit, Orn, Ile, 0.750, 0.683, 2.6%, 0.692, 0.684; Asn, Gln, Cit, Tyr, Leu, 0.750, 0.730, 2.0%, 0.732, 0.712; Asn, Gln, His, Tyr, Val, 0.750, 0.736, 2.2%, 0.734, 0.730; Asn, Gln, Tyr, Met, Leu, 0.750, 0.731, 3.5%, 0.729, 0.698; Asn, Thr, Val, Lys, Ile, 0.750, 0.678, 2.6%, 0.651, 0.659; Gln, His, Pro, Val, Ile, 0.750, 0.708, 1.1%, 0.728, 0.732; Gln, Tyr, Lys, Leu, Trp, 0.750, 0.727, 4.2%, 0.708, 0.734; Gln, Tyr, Val, Ile, Leu, 0.750, 0.724, 3.5%, 0.728, 0.742; Gly, Gln, Cit, Orn, Ile, 0.750, 0.679, 1.8%, 0.678, 0.673; Gly, Gln, His, Val, Ile, 0.750, 0.703, 0.9%, 0.718, 0.720; His, Thr, Tyr, Met, Ile, 0.750, 0.726, 5.0%, 0.728, 0.696; His, Tyr, Orn, Ile, Phe, 0.750, 0.719, 2.9%, 0.714, 0.690; Asn, Gln, Cit, Lys, Leu, 0.750, 0.678, 0.2%, 0.650, 0.621; Asn, Gln, Cit, Tyr, Ile, 0.750, 0.729, 3.5%, 0.745, 0.744; Asn, Gln, Lys, Leu, Trp, 0.750, 0.678, 0.2%, 0.650, 0.625; Asn, Gln, Thr, Lys, Ile, 0.750, 0.680, 1.5%, 0.656, 0.679; Asn, His, Met, Lys, Ile, 0.750, 0.687, 3.3%, 0.663, 0.623; Gln, His, Val, Ile, Trp, 0.750, 0.708, 1.5%, 0.723, 0.714; Gln, Met, Lys, Ile, Phe, 0.750, 0.678, 1.1%, 0.655, 0.667; Gln, Thr, Lys, Ile, Trp, 0.750, 0.682, 0.9%, 0.659, 0.706; Gln, Tyr, Met, Ile, Leu, 0.750, 0.730, 3.7%, 0.732, 0.714; Gly, Gln, His, Arg, Ile, 0.750, 0.704, 0.9%, 0.723, 0.712; Gly, Gln, Met, Lys, Ile, 0.750, 0.675, 0.7%, 0.648, 0.694; Gly, Gln, Orn, Lys, Ile, 0.750, 0.678, 0.7%, 0.650, 0.696; His, Arg, Lys, Ile, Phe, 0.750, 0.678, 0.4%, 0.662, 0.661; His, Arg, Tyr, Met, Ile, 0.750, 0.729, 5.1%, 0.735, 0.710; His, Tyr, Ile, Phe, Trp, 0.750, 0.708, 4.2%, 0.700, 0.667; Ser, Arg, Lys, Ile, Trp, 0.750, 0.655, 2.9%, 0.630, 0.673; Ser, Gln, Lys, Ile, Trp, 0.750, 0.662, 1.5%, 0.631, 0.692; Arg, Val, Lys, Ile, Phe, 0.750, 0.672, 0.9%, 0.659, 0.671; Asn, Cit, Met, Lys, Ile, 0.750, 0.679, 1.8%, 0.668, 0.680; Asn, Gln, Pro, Lys, Ile, 0.750, 0.677, 2.0%, 0.656, 0.667; Asn, Gln, Val, Lys, Leu, 0.750, 0.679, 0.2%, 0.647, 0.615; Asn, Gly, Thr, Lys, Ile, 0.750, 0.674, 2.6%, 0.647, 0.659; Asn, Gly, Tyr, Met, Leu, 0.750, 0.721, 4.4%, 0.697, 0.629; Asn, His, Val, Orn, Lys, 0.750, 0.688, 1.3%, 0.669, 0.617; Asn, Thr, Met, Lys, Ile, 0.750, 0.675, 2.4%, 0.648, 0.663; Gln, Ala, Tyr, Leu, Trp, 0.750, 0.724, 4.2%, 0.713, 0.710; Gln, His, Thr, Ala, Ile, 0.750, 0.706, 1.1%, 0.726, 0.734; Gly, Gln, His, Ile, Leu, 0.750, 0.703, 0.9%, 0.717, 0.712; Gly, Gln, His, Met, Ile, 0.750, 0.702, 0.9%, 0.714, 0.708; Gly, His, Tyr, Met, Ile, 0.750, 0.723, 4.6%, 0.718, 0.698; Ser, Gln, Val, Lys, Ile, 0.750, 0.658, 1.7%, 0.636, 0.720; Tyr, Met, Ile, Leu, Phe, 0.750, 0.721, 4.2%, 0.710, 0.663; Asn, Cit, Arg, Tyr, Ile, 0.749, 0.727, 4.8%, 0.739, 0.710; Asn, Cit, Tyr, Ile, Trp, 0.749, 0.729, 6.6%, 0.738, 0.712; Asn, Gln, Ala, Lys, Leu, 0.749, 0.678, 0.6%, 0.659, 0.643; Asn, Gln, Thr, Tyr, Leu, 0.749, 0.733, 3.7%, 0.728, 0.700; Asn, Gly, Tyr, Lys, Leu, 0.749, 0.711, 3.3%, 0.682, 0.655; Asn, His, Ile, Phe, Trp, 0.749, 0.688, 0.4%, 0.690, 0.623; Asn, His, Lys, Ile, Leu, 0.749, 0.681, 4.0%, 0.664, 0.655; Asn, His, Orn, Ile, Phe, 0.749, 0.684, 0.9%, 0.687, 0.611; Asn, His, Thr, Ile, Phe, 0.749, 0.691, 0.7%, 0.693, 0.619; Asn, Orn, Lys, Ile, Leu, 0.749, 0.678, 1.7%, 0.654, 0.661; Asn, Pro, Tyr, Leu, Phe, 0.749, 0.719, 2.4%, 0.707, 0.639; Cit, Tyr, Met, Orn, Ile, 0.749, 0.709, 5.1%, 0.714, 0.714; Gln, Ala, Cit, Tyr, Ile, 0.749, 0.730, 3.7%, 0.747, 0.761; Gln, Ala, Tyr, Lys, Leu, 0.749, 0.715, 3.5%, 0.708, 0.728; Gln, His, Ala, Ile, Leu, 0.749, 0.705, 1.1%, 0.723, 0.728; Gln, His, Ile, Leu, Trp, 0.749, 0.707, 1.5%, 0.720, 0.702; Gln, His, Orn, Ile, Trp, 0.749, 0.699, 2.4%, 0.714, 0.704; Gln, His, Orn, Lys, Ile, 0.749, 0.693, 1.7%, 0.691, 0.710; Gln, His, Pro, Ile, Trp, 0.749, 0.707, 1.7%, 0.723, 0.710; Gln, His,

 Thr, Ile, Leu, 0.749, 0.707, 1.1%, 0.725, 0.734; Gln, His, Tyr, Orn, Leu, 0.749, 0.719, 2.0%, 0.723, 0.748; Gln, Tyr, Lys, Ile, Leu, 0.749, 0.718, 3.7%, 0.716, 0.746; Gln, Val, Lys, Ile, Leu, 0.749, 0.680, 0.7%, 0.666, 0.712; Gln, Val, Lys, Ile, Trp, 0.749, 0.678, 1.1%, 0.656, 0.712; His, Cit, Tyr, Lys, Ile, 0.749, 0.711, 3.5%, 0.711, 0.750; His, Pro, Tyr, Met, Ile, 0.749, 0.725, 4.8%, 0.725, 0.706; Ser, Asn, Gln, Orn, Leu, 0.749, 0.668, 0.2%, 0.649, 0.596; Ser, Gln, Lys, Ile, Phe, 0.749, 0.661, 0.9%, 0.636, 0.671; Ala, Cit, Tyr, Lys, Ile, 0.749, 0.708, 4.2%, 0.703, 0.736; Asn, Ala, Arg, Lys, Ile, 0.749, 0.670, 3.7%, 0.666, 0.686; Asn, Gln, Arg, Tyr, Ile, 0.749, 0.727, 5.3%, 0.739, 0.732; Asn, Gln, His, Pro, Tyr, 0.749, 0.735, 2.4%, 0.751, 0.738; Asn, Gln, Met, Lys, Ile, 0.749, 0.679, 2.0%, 0.658, 0.680; Asn, Gln, Tyr, Orn, Leu, 0.749, 0.720, 2.8%, 0.717, 0.684; Asn, Gln, Tyr, Val, Ile, 0.749, 0.727, 7.2%, 0.725, 0.714; Asn, Gly, Gln, Cit, Ile, 0.749, 0.688, 0.7%, 0.692, 0.667; Asn, His, Arg, Ile, Phe, 0.749, 0.690, 0.0%, 0.695, 0.623; Asn, His, Arg, Lys, Ile, 0.749, 0.683, 1.8%, 0.685, 0.684; Asn, Met, Lys, Ile, Leu, 0.749, 0.677, 1.8%, 0.651, 0.657; Asn, Thr, Orn, Lys, Ile, 0.749, 0.678, 2.4%, 0.651, 0.661; Asn, Val, Lys, Ile, Leu, 0.749, 0.674, 1.3%, 0.650, 0.649; Cit, Arg, Lys, Ile, Phe, 0.749, 0.672, 0.9%, 0.660, 0.669; Cit, Pro, Tyr, Orn, Ile, 0.749, 0.702, 5.0%, 0.709, 0.738; Gln, Cit, Pro, Tyr, Ile, 0.749, 0.729, 3.9%, 0.747, 0.757; Gln, Cit, Tyr, Lys, Ile, 0.749, 0.718, 3.5%, 0.725, 0.783; Gln, His, Lys, Ile, Trp, 0.749, 0.702, 1.7%, 0.695, 0.692; Gln, His, Thr, Val, Ile, 0.749, 0.706, 1.1%, 0.724, 0.734; Gln, His, Val, Orn, Ile, 0.749, 0.697, 1.3%, 0.715, 0.714; Gln, Met, Lys, Ile, Trp, 0.749, 0.684, 0.9%, 0.660, 0.712; Gln, Pro, Tyr, Ile, Leu, 0.749, 0.724, 3.5%, 0.729, 0.746; Gln, Thr, Cit, Tyr, Ile, 0.749, 0.728, 3.1%, 0.746, 0.759; Gln, Tyr, Orn, Ile, Leu, 0.749, 0.723, 3.9%, 0.728, 0.742; Gln, Tyr, Val, Ile, Trp, 0.749, 0.732, 7.4%, 0.723, 0.726; Gly, Arg, Lys, Ile, Phe, 0.749, 0.670, 0.9%, 0.654, 0.663; Gly, Cit, Tyr, Ile, Phe, 0.749, 0.710, 5.1%, 0.709, 0.704; Gly, Cit, Tyr, Ile, Trp, 0.749, 0.713, 4.8%, 0.705, 0.714; Gly, Gln, Cit, Pro, Ile, 0.749, 0.690, 0.7%, 0.691, 0.677; Gly, Gln, His, Lys, Ile, 0.749, 0.691, 1.3%, 0.683, 0.702; Gly, Gln, His, Pro, Ile, 0.749, 0.702, 1.1%, 0.716, 0.716; Gly, His, Arg, Tyr, Ile, 0.749, 0.718, 3.5%, 0.723, 0.718; His, Tyr, Met, Ile, Leu, 0.749, 0.727, 4.0%, 0.724, 0.698; His, Tyr, Met, Orn, Ile, 0.749, 0.726, 4.8%, 0.727, 0.708; Ser, Arg, Lys, Ile, Phe, 0.749, 0.655, 1.1%, 0.637, 0.653; Ser, Asn, Gln, Lys, Leu, 0.749, 0.673, 0.4%, 0.642, 0.625; Arg, Tyr, Lys, Leu, Trp, 0.748, 0.714, 4.0%, 0.692, 0.684; Arg, Tyr, Val, Lys, Trp, 0.748, 0.724, 5.9%, 0.703, 0.718; Asn, Cit, Lys, Ile, Trp, 0.748, 0.679, 1.7%, 0.668, 0.680; Asn, Cit, Tyr, Leu, Phe, 0.748, 0.723, 1.5%, 0.716, 0.651; Asn, Gln, Val, Orn, Lys, 0.748, 0.675, 2.0%, 0.638, 0.613; Asn, Gly, Gln, Tyr, Val, 0.748, 0.729, 7.7%, 0.708, 0.692; Asn, His, Tyr, Ile, Trp, 0.748, 0.722, 4.2%, 0.724, 0.692; Asn, His, Tyr, Leu, Phe, 0.748, 0.724, 1.7%, 0.716, 0.657; Asn, Pro, Lys, Ile, Leu, 0.748, 0.674, 2.4%, 0.649, 0.657; Asn, Tyr, Lys, Ile, Phe, 0.748, 0.707, 6.1%, 0.688, 0.663; Asn, Tyr, Lys, Leu, Trp, 0.748, 0.717, 3.5%, 0.688, 0.657; Asn, Tyr, Met, Ile, Leu, 0.748, 0.728, 5.7%, 0.718, 0.673; Cit, Tyr, Ile, Leu, Trp, 0.748, 0.717, 4.4%, 0.710, 0.700; Cit, Tyr, Met, Lys, Ile, 0.748, 0.713, 3.9%, 0.704, 0.720; Gln, Ala, Lys, Ile, Trp, 0.748, 0.679, 0.9%, 0.659, 0.706; Gln, Arg, Tyr, Ile, Leu, 0.748, 0.727, 2.9%, 0.736, 0.740; Gln, Cit, Arg, Orn, Ile, 0.748, 0.682, 2.9%, 0.690, 0.679; Gln, Cit, Orn, Ile, Phe, 0.748, 0.682, 1.7%, 0.689, 0.671; Gln, Cit, Orn, Ile, Trp, 0.748, 0.683, 3.1%, 0.689, 0.679; Gln, Cit, Orn, Lys, Ile, 0.748, 0.673, 1.8%, 0.663, 0.712; Gln, Cit, Tyr, Ile, Trp, 0.748, 0.734, 4.0%, 0.742, 0.765; Gln, Cit, Tyr, Lys, Leu, 0.748, 0.717, 2.0%, 0.715, 0.744; Gln, His, Cit, Lys, Ile, 0.748, 0.698, 1.1%, 0.702, 0.722; Gln, His, Thr, Pro, Ile, 0.748, 0.707, 1.1%, 0.725, 0.732; Gln, His, Tyr, Val, Orn, 0.748, 0.721, 2.6%, 0.721, 0.736; Gln, Lys, Ile, Phe, Trp, 0.748, 0.677, 0.6%, 0.655, 0.659; Gln, Orn, Lys, Ile, Trp, 0.748, 0.678, 0.9%, 0.653, 0.704; Gln, Orn, Lys, Leu, Phe, 0.748, 0.671, 0.2%, 0.641, 0.604; Gln, Pro, Tyr, Leu, Trp, 0.748, 0.725, 5.1%, 0.712, 0.712; Gln, Pro, Tyr, Lys, Leu, 0.748, 0.719, 3.7%, 0.712, 0.730; Gln, Thr, Lys, Leu, Phe, 0.748, 0.675, 0.0%, 0.647, 0.615; Gln, Tyr, Met, Ile, Trp, 0.748, 0.731, 7.5%, 0.735, 0.734; Gln, Tyr, Met, Leu, Trp, 0.748, 0.734, 4.2%, 0.724, 0.708; Gln, Tyr, Val, Leu, Trp, 0.748, 0.727, 4.4%, 0.710, 0.710; Gln, Tyr, Val, Lys, Ile, 0.748, 0.716, 4.4%, 0.716, 0.755; Gly, Gln, Tyr, Met, Leu, 0.748, 0.717, 2.6%, 0.706, 0.680; Gly, Gln, Tyr, Val, Ile, 0.748, 0.721, 6.1%, 0.718, 0.722; Gly, Gln, Tyr, Val, Leu, 0.748, 0.718, 2.9%, 0.707, 0.706; Gly, Gln, Tyr, Val, Phe, 0.748, 0.724, 6.4%, 0.704, 0.677; Gly, Gln, Val, Lys, Ile, 0.748, 0.673, 1.1%, 0.651, 0.702; His, Tyr, Val, Met, Ile, 0.748, 0.728, 7.9%, 0.720, 0.694; Ser, Arg, Met, Lys, Ile, 0.748, 0.660, 1.7%, 0.639, 0.677; Ser, Asn, His, Lys, Ile, 0.748, 0.669, 3.5%, 0.652, 0.667; Ser, Thr, Tyr, Leu, Phe, 0.748, 0.721, 2.4%, 0.717, 0.655; Thr, Tyr, Lys, Ile, Phe, 0.748, 0.715, 5.3%, 0.703, 0.688; Tyr, Lys, Ile, Leu, Phe, 0.748, 0.707, 3.9%, 0.687, 0.651; Arg, Tyr, Lys, Leu, Phe, 0.747, 0.715, 1.3%, 0.704, 0.665; Asn, Ala, Cit, Tyr, Ile, 0.747, 0.728, 5.0%, 0.740, 0.716; Asn, Arg, Tyr, Ile, Leu, 0.747, 0.723, 4.4%, 0.723, 0.684; Asn, Cit, Tyr, Ile, Leu, 0.747, 0.723, 3.1%, 0.727, 0.694; Asn, Gln, His, Tyr, Orn, 0.747, 0.718, 2.4%, 0.741, 0.744; Asn, Gln, Tyr, Ile, Trp, 0.747, 0.727, 7.0%, 0.730, 0.720; Asn, Gly, Arg, Tyr, Leu, 0.747, 0.717, 3.1%, 0.703, 0.649; Asn, Gly, His, Tyr, Leu, 0.747, 0.715, 2.4%, 0.699, 0.647; Asn, His, Ala, Cit, Ile, 0.747, 0.702, 1.8%, 0.713, 0.669; Asn, His, Ala, Lys, Ile, 0.747, 0.680, 3.5%, 0.667, 0.671; Asn, His, Ile, Leu, Phe, 0.747, 0.690, 0.6%, 0.684, 0.602; Asn, His, Met, Ile, Trp, 0.747, 0.696, 1.3%, 0.700, 0.613; Asn, His, Tyr, Orn, Ile, 0.747, 0.727, 4.6%, 0.730, 0.708; Asn, Met, Orn, Lys, Ile, 0.747, 0.678, 2.6%, 0.656, 0.667; Asn, Tyr, Leu, Phe, Trp, 0.747, 0.721, 2.6%, 0.705, 0.635; Asn, Tyr, Orn, Leu, Phe, 0.747, 0.720, 2.6%, 0.708, 0.645; Asn, Tyr, Val, Leu, Phe, 0.747, 0.722, 2.2%, 0.712, 0.643; Cit, Pro, Tyr, Val, Ile, 0.747, 0.718, 5.9%, 0.718, 0.726; Gln, Ala, Cit, Ile, Trp, 0.747, 0.693, 0.7%, 0.705, 0.700; Gln, Ala, Tyr, Ile, Leu, 0.747, 0.723, 3.9%, 0.727, 0.738; Gln, Cit, Tyr, Orn, Leu, 0.747, 0.708, 2.0%, 0.713, 0.728; Gln, His, Cit, Tyr, Leu, 0.747, 0.726, 2.2%, 0.734, 0.746; Gln, His, Thr, Ile, Trp, 0.747, 0.705, 1.8%, 0.722, 0.722; Gln, His, Tyr, Met, Lys, 0.747, 0.734, 1.7%, 0.729, 0.765; Gln, Thr, Val, Lys, Ile, 0.747, 0.677, 1.1%, 0.660, 0.712; Gln, Tyr, Val, Lys, Leu, 0.747, 0.722, 3.5%, 0.710, 0.740; Gln, Val, Met, Lys, Ile, 0.747, 0.677, 1.1%, 0.658, 0.708; Gln, Val, Orn, Lys, Ile, 0.747, 0.675, 1.1%, 0.658, 0.708; Gly, Gln, Ala, Lys, Ile, 0.747, 0.676, 0.9%, 0.654, 0.702; Gly, Gln, His, Ile, Trp, 0.747, 0.702, 1.5%, 0.710, 0.700; Gly, Gln, Thr, Tyr, Leu, 0.747, 0.722, 6.4%, 0.712, 0.696; Gly, His, Cit, Tyr, Ile, 0.747, 0.710, 3.1%, 0.713, 0.738; His, Arg, Met, Lys, Ile, 0.747, 0.683, 0.7%, 0.668, 0.667; Ser, Asn, Arg, Tyr, Ile, 0.747, 0.716, 5.7%, 0.719, 0.712; Ser, Asn, Cit, Lys, Ile, 0.747, 0.664, 2.4%, 0.645, 0.663; Ser, Asn, Gln, Tyr, Leu, 0.747, 0.724, 2.8%, 0.719, 0.696; Ser, Gln, Tyr, Lys, Leu, 0.747, 0.719, 3.7%, 0.709, 0.732; Ser, Gly, Gln, Lys, Ile, 0.747, 0.661, 1.7%, 0.633, 0.700; Thr, Pro, Tyr, Leu, Phe, 0.747, 0.718, 3.7%, 0.713, 0.647; Thr, Tyr, Val, Leu, Phe, 0.747, 0.723, 2.8%, 0.714, 0.661; Tyr, Ile, Leu, Phe, Trp, 0.747, 0.713, 4.2%, 0.697, 0.639; Arg, Lys, Ile, Leu, Phe, 0.747, 0.671, 0.7%, 0.656, 0.661; Arg, Pro, Tyr, Orn, Lys, 0.747, 0.686, 7.7%, 0.678, 0.765; Asn, Arg, Tyr, Orn, Lys, 0.747, 0.695, 6.1%, 0.690, 0.736; Asn, Cit, Pro, Tyr, Ile, 0.747, 0.728, 5.3%, 0.740, 0.716; Asn, Cit, Tyr, Val, Ile, 0.747, 0.728, 4.2%, 0.732, 0.702; Asn, Gln, Ile, Leu, Trp, 0.747, 0.701, 0.4%, 0.701, 0.655; Asn, Gln, Orn, Leu, Phe, 0.747, 0.676, 0.0%, 0.661, 0.586; Asn, Gly, His, Ile, Phe, 0.747, 0.689, 0.9%, 0.690, 0.617; Asn, Gly, His, Lys, Ile, 0.747, 0.681, 4.2%, 0.664, 0.653; Asn, Gly, Met, Lys, Ile, 0.747, 0.673, 2.6%, 0.645, 0.665; Asn, His, Cit, Ile, Phe, 0.747, 0.692, 0.6%, 0.700, 0.641; Asn, His, Orn, Lys, Ile, 0.747, 0.681, 4.0%, 0.664, 0.655; Asn, His, Pro, Met, Ile, 0.747, 0.696, 1.7%, 0.700, 0.617; Asn, His, Thr, Lys, Ile, 0.747, 0.687, 5.0%, 0.670, 0.653; Asn, His, Val, Ile, Phe, 0.747, 0.690, 0.7%, 0.689, 0.619; Asn, His, Val, Lys, Phe, 0.747, 0.687, 0.6%, 0.662, 0.604; Asn, Tyr, Met, Lys, Leu, 0.747, 0.722, 3.3%, 0.697, 0.667; Gln, Ala, Cit, Lys, Ile, 0.747, 0.682, 1.1%, 0.677, 0.730; Gln, Ala, Tyr, Lys, Ile, 0.747, 0.717, 4.6%, 0.714, 0.757; Gln, Cit, Lys, Ile, Leu, 0.747, 0.683, 0.7%, 0.674, 0.722; Gln, Cit, Tyr, Leu, Trp, 0.747, 0.730, 2.6%, 0.722, 0.720; Gln, Cit, Tyr, Met, Leu, 0.747, 0.729, 2.0%, 0.732, 0.724; Gln, His, Lys, Ile, Leu, 0.747, 0.696, 1.7%, 0.696, 0.738; Gln, His, Orn, Ile, Leu, 0.747, 0.697, 1.5%, 0.713, 0.702; Gln, His, Orn, Leu, Phe, 0.747, 0.686, 0.0%, 0.677, 0.621; Gln, His, Thr, Orn, Ile, 0.747, 0.697, 1.5%, 0.713, 0.712; Gln, Orn, Leu, Phe, Trp, 0.747, 0.673, 0.2%, 0.657, 0.596; Gln, Pro, Tyr, Met, Ile, 0.747, 0.732, 5.9%, 0.739, 0.740; Gln, Pro, Tyr, Met, Leu, 0.747, 0.727, 2.8%, 0.726, 0.704; Gln, Thr, Tyr, Lys, Leu, 0.747, 0.717, 3.9%, 0.707, 0.718; Gln, Tyr, Orn, Lys, Ile, 0.747, 0.721, 4.8%, 0.719, 0.763; Gln, Tyr, Orn, Lys, Leu, 0.747, 0.716, 2.9%, 0.704, 0.734; Gln, Val, Ile, Leu, Phe, 0.747, 0.692, 0.2%, 0.698, 0.633; Gly, Gln, Pro, Tyr, Leu, 0.747, 0.716, 3.1%, 0.703, 0.698; His, Ala, Tyr, Met, Ile, 0.747, 0.726, 5.1%, 0.725, 0.712; His, Cit, Tyr, Val, Ile, 0.747, 0.717, 2.9%, 0.718, 0.742; His, Met, Lys, Ile, Phe, 0.747, 0.671, 0.9%, 0.638, 0.588; His, Tyr, Leu, Phe, Trp, 0.747, 0.715, 2.8%, 0.692, 0.621; Ser, Cit, Tyr, Lys, Ile, 0.747, 0.704, 4.4%, 0.700, 0.734; Ser, Gln, His, Orn, Ile, 0.747, 0.687, 0.9%, 0.702, 0.726; Ser, Gln, Lys, Leu, Phe, 0.747, 0.669, 0.2%, 0.639, 0.625; Ser, Gln, Tyr, Ile, Leu, 0.747, 0.713, 4.0%

, 0.718, 0.746; Ser, Gln, Tyr, Val, Ile, 0.747, 0.717, 4.6%, 0.722, 0.755; Ser, Gly, Cit, Tyr, Ile, 0.747, 0.714, 4.4%, 0.715, 0.736; Thr, Cit, Tyr, Ile, Phe, 0.747, 0.719, 4.2%, 0.728, 0.700; Thr, Tyr, Lys, Leu, Phe, 0.747, 0.718, 2.4%, 0.708, 0.661; Thr, Tyr, Met, Leu, Phe, 0.747, 0.723, 2.6%, 0.714, 0.645; Tyr, Met, Orn, Ile, Phe, 0.747, 0.730, 7.2%, 0.725, 0.679; Tyr, Val, Met, Ile, Phe, 0.747, 0.725, 6.4%, 0.713, 0.675; Ala, Cit, Tyr, Ile, Phe, 0.746, 0.713, 5.0%, 0.725, 0.706; Asn, Arg, Tyr, Val, Ile, 0.746, 0.729, 6.6%, 0.726, 0.698; Asn, Cit, Tyr, Lys, Leu, 0.746, 0.713, 2.0%, 0.694, 0.675; Asn, Gln, His, Lys, Leu, 0.746, 0.688, 0.4%, 0.672, 0.649; Asn, Gln, Pro, Tyr, Ile, 0.746, 0.729, 4.8%, 0.735, 0.724; Asn, Gln, Val, Lys, Phe, 0.746, 0.684, 0.4%, 0.650, 0.617; Asn, Gly, Orn, Lys, Ile, 0.746, 0.677, 2.2%, 0.650, 0.663; Asn, Gly, Tyr, Ile, Leu, 0.746, 0.713, 4.6%, 0.697, 0.659; Asn, His, Arg, Orn, Ile, 0.746, 0.688, 1.5%, 0.701, 0.655; Asn, His, Cit, Pro, Ile, 0.746, 0.705, 0.6%, 0.711, 0.661; Asn, His, Tyr, Val, Ile, 0.746, 0.723, 5.0%, 0.722, 0.692; Asn, Lys, Ile, Leu, Trp, 0.746, 0.677, 1.5%, 0.652, 0.659; Asn, Orn, Lys, Ile, Phe, 0.746, 0.679, 2.6%, 0.649, 0.643; Asn, Thr, Tyr, Lys, Leu, 0.746, 0.715, 4.0%, 0.694, 0.677; Cit, Arg, Pro, Tyr, Lys, 0.746, 0.698, 4.8%, 0.685, 0.779; Cit, Pro, Tyr, Lys, Ile, 0.746, 0.702, 5.3%, 0.700, 0.746; Cit, Tyr, Lys, Ile, Phe, 0.746, 0.705, 4.8%, 0.699, 0.702; Cit, Tyr, Orn, Ile, Trp, 0.746, 0.703, 4.8%, 0.708, 0.728; Cit, Tyr, Orn, Lys, Ile, 0.746, 0.696, 4.4%, 0.694, 0.732; Gln, Ala, Ile, Leu, Trp, 0.746, 0.695, 1.1%, 0.690, 0.663; Gln, Ala, Tyr, Leu, Phe, 0.746, 0.719, 2.0%, 0.721, 0.682; Gln, Arg, Tyr, Ile, Trp, 0.746, 0.730, 7.2%, 0.740, 0.746; Gln, Arg, Tyr, Met, Ile, 0.746, 0.730, 5.7%, 0.741, 0.742; Gln, Cit, Arg, Tyr, Ile, 0.746, 0.730, 2.8%, 0.745, 0.757; Gln, Cit, Tyr, Val, Ile, 0.746, 0.729, 4.2%, 0.742, 0.753; Gln, Pro, Tyr, Ile, Trp, 0.746, 0.735, 8.1%, 0.739, 0.755; Gln, Pro, Tyr, Lys, Ile, 0.746, 0.716, 4.4%, 0.715, 0.751; Gln, Thr, Lys, Ile, Leu, 0.746, 0.685, 0.9%, 0.661, 0.694; Gln, Thr, Met, Lys, Ile, 0.746, 0.682, 0.9%, 0.658, 0.704; Gln, Thr, Orn, Leu, Phe, 0.746, 0.673, 0.0%, 0.655, 0.600; Gln, Thr, Orn, Lys, Ile, 0.746, 0.682, 1.1%, 0.659, 0.704; Gln, Tyr, Val, Met, Leu, 0.746, 0.728, 2.6%, 0.725, 0.712; Gly, Ala, Cit, Tyr, Ile, 0.746, 0.713, 4.0%, 0.712, 0.722; Gly, Gln, Arg, Tyr, Leu, 0.746, 0.717, 2.4%, 0.713, 0.704; Gly, Gln, His, Tyr, Val, 0.746, 0.730, 3.9%, 0.724, 0.740; Gly, Gln, Ile, Leu, Phe, 0.746, 0.685, 0.2%, 0.685, 0.633; Ser, Asn, Tyr, Leu, Phe, 0.746, 0.726, 2.4%, 0.717, 0.643; Ser, Gln, Arg, Tyr, Ile, 0.746, 0.715, 4.2%, 0.728, 0.759; Ser, Gln, Cit, Lys, Ile, 0.746, 0.669, 1.3%, 0.650, 0.718; Ser, Gln, His, Ala, Ile, 0.746, 0.691, 1.1%, 0.707, 0.732; Ser, Gln, His, Tyr, Leu, 0.746, 0.724, 2.0%, 0.728, 0.738; Ser, Gln, Met, Lys, Ile, 0.746, 0.660, 1.5%, 0.635, 0.706; Ser, Gln, Thr, Lys, Ile, 0.746, 0.659, 1.8%, 0.635, 0.708; Ser, Gln, Thr, Tyr, Ile, 0.746, 0.710, 5.7%, 0.720, 0.748; Thr, Tyr, Met, Ile, Phe, 0.746, 0.719, 5.7%, 0.718, 0.667; Ala, Cit, Tyr, Val, Ile, 0.745, 0.717, 5.5%, 0.716, 0.724; Ala, Tyr, Met, Lys, Ile, 0.745, 0.711, 5.5%, 0.693, 0.714; Asn, Gln, His, Orn, Lys, 0.745, 0.671, 2.4%, 0.665, 0.690; Asn, Gly, Tyr, Leu, Trp, 0.745, 0.716, 3.3%, 0.691, 0.637; Asn, Gly, Tyr, Val, Leu, 0.745, 0.714, 2.4%, 0.694, 0.639; Asn, His, Ala, Tyr, Ile, 0.745, 0.721, 4.4%, 0.725, 0.694; Asn, His, Cit, Orn, Ile, 0.745, 0.687, 2.0%, 0.694, 0.647; Asn, His, Lys, Ile, Trp, 0.745, 0.681, 4.4%, 0.665, 0.655; Asn, His, Pro, Lys, Ile, 0.745, 0.679, 3.9%, 0.662, 0.655; Asn, Pro, Lys, Ile, Phe, 0.745, 0.672, 3.3%, 0.638, 0.639; Asn, Thr, Cit, Tyr, Ile, 0.745, 0.728, 6.2%, 0.739, 0.712; Asn, Thr, Lys, Ile, Phe, 0.745, 0.677, 2.8%, 0.645, 0.633; Asn, Thr, Lys, Ile, Trp, 0.745, 0.672, 2.2%, 0.647, 0.661; Asn, Thr, Tyr, Lys, Ile, 0.745, 0.710, 8.6%, 0.695, 0.690; Asn, Tyr, Lys, Ile, Leu, 0.745, 0.706, 4.4%, 0.690, 0.679; Asn, Val, Lys, Ile, Phe, 0.745, 0.674, 3.1%, 0.640, 0.635; Asn, Val, Met, Lys, Ile, 0.745, 0.674, 2.8%, 0.647, 0.663; Cit, Arg, Tyr, Ile, Phe, 0.745, 0.720, 3.7%, 0.730, 0.702; Cit, Tyr, Met, Ile, Phe, 0.745, 0.717, 4.0%, 0.722, 0.688; Cit, Tyr, Orn, Ile, Phe, 0.745, 0.702, 4.6%, 0.713, 0.702; Gln, Ala, Cit, Arg, Ile, 0.745, 0.693, 0.7%, 0.708, 0.702; Gln, Ala, Lys, Ile, Phe, 0.745, 0.671, 1.5%, 0.652, 0.677; Gln, Ala, Val, Lys, Ile, 0.745, 0.679, 1.3%, 0.664, 0.714; Gln, Cit, Val, Orn, Ile, 0.745, 0.683, 3.1%, 0.685, 0.669; Gln, His, Thr, Lys, Ile, 0.745, 0.696, 1.3%, 0.694, 0.716; Gln, Met, Lys, Ile, Leu, 0.745, 0.685, 0.7%, 0.662, 0.700; Gln, Tyr, Met, Lys, Leu, 0.745, 0.724, 2.4%, 0.708, 0.700; Gly, Cit, Pro, Tyr, Ile, 0.745, 0.712, 4.2%, 0.713, 0.736; Gly, Cit, Tyr, Orn, Ile, 0.745, 0.701, 4.2%, 0.703, 0.724; Gly, Gln, His, Thr, Ile, 0.745, 0.700, 1.1%, 0.715, 0.724; Gly, Gln, Lys, Ile, Leu, 0.745, 0.676, 0.7%, 0.649, 0.686; Gly, Gln, Lys, Leu, Phe, 0.745, 0.673, 0.2%, 0.637, 0.606; Gly, Gln, Pro, Lys, Ile, 0.745, 0.670, 1.1%, 0.645, 0.688; Ser, Asn, Gln, Leu, Phe, 0.745, 0.671, 0.0%, 0.657, 0.600; Ser, Asn, His, Ile, Phe, 0.745, 0.675, 0.6%, 0.677, 0.631; Ser, Cit, Tyr, Orn, Ile, 0.745, 0.702, 4.2%, 0.710, 0.732; Ser, Gln, His, Ile, Leu, 0.745, 0.693, 0.9%, 0.710, 0.734; Ser, Gln, His, Ile, Trp, 0.745, 0.687, 1.5%, 0.701, 0.720; Ser, Gln, His, Pro, Ile, 0.745, 0.693, 1.1%, 0.710, 0.738; Ser, Gln, His, Thr, Ile, 0.745, 0.693, 1.1%, 0.708, 0.730; Ser, Gly, Gln, Tyr, Leu, 0.745, 0.723, 3.1%, 0.711, 0.702; Ser, Tyr, Met, Leu, Phe, 0.745, 0.727, 2.4%, 0.714, 0.643; Ala, Tyr, Lys, Ile, Phe, 0.745, 0.700, 6.4%, 0.680, 0.671; Ala, Tyr, Met, Ile, Phe, 0.745, 0.718, 6.6%, 0.709, 0.665; Arg, Orn, Lys, Ile, Trp, 0.745, 0.667, 2.8%, 0.653, 0.675; Asn, Gln, Ala, Tyr, Leu, 0.745, 0.722, 2.9%, 0.717, 0.690; Asn, Gln, Arg, Tyr, Leu, 0.745, 0.729, 3.1%, 0.725, 0.704; Asn, Gln, Cit, Pro, Ile, 0.745, 0.699, 0.9%, 0.713, 0.696; Asn, Gln, Met, Lys, Leu, 0.745, 0.678, 0.4%, 0.651, 0.627; Asn, Gln, Tyr, Met, Ile, 0.745, 0.727, 5.9%, 0.732, 0.710; Asn, Gln, Val, Leu, Phe, 0.745, 0.685, 0.0%, 0.675, 0.590; Asn, Gly, Lys, Ile, Leu, 0.745, 0.674, 1.7%, 0.644, 0.647; Asn, Gly, Pro, Tyr, Leu, 0.745, 0.712, 2.4%, 0.693, 0.639; Asn, His, Pro, Ile, Phe, 0.745, 0.687, 0.7%, 0.690, 0.621; Asn, His, Val, Met, Lys, 0.745, 0.688, 1.5%, 0.671, 0.625; Asn, Thr, Pro, Lys, Ile, 0.745, 0.671, 3.3%, 0.642, 0.659; Gln, Ala, Tyr, Met, Leu, 0.745, 0.722, 2.2%, 0.719, 0.710; Gln, Arg, Tyr, Val, Lys, 0.745, 0.726, 3.1%, 0.719, 0.732; Gln, Cit, Met, Lys, Ile, 0.745, 0.683, 0.7%, 0.675, 0.728; Gln, Cit, Val, Lys, Ile, 0.745, 0.680, 0.9%, 0.675, 0.730; Gln, His, Lys, Leu, Phe, 0.745, 0.688, 0.0%, 0.671, 0.655; Gln, His, Met, Lys, Ile, 0.745, 0.697, 0.9%, 0.691, 0.700; Gln, His, Pro, Lys, Ile, 0.745, 0.695, 2.0%, 0.695, 0.714; Gln, His, Val, Lys, Ile, 0.745, 0.692, 1.7%, 0.698, 0.732; Gln, Met, Orn, Lys, Ile, 0.745, 0.680, 1.1%, 0.655, 0.700; Gln, Thr, Arg, Tyr, Ile, 0.745, 0.728, 5.7%, 0.743, 0.750; Gln, Thr, Tyr, Ile, Trp, 0.745, 0.727, 7.5%, 0.733, 0.746; Gln, Thr, Tyr, Met, Ile, 0.745, 0.730, 5.9%, 0.737, 0.738; Gln, Val, Orn, Leu, Phe, 0.745, 0.674, 0.2%, 0.656, 0.596; Gly, Cit, Tyr, Lys, Ile, 0.745, 0.701, 4.4%, 0.694, 0.726; Gly, Gln, Orn, Lys, Leu, 0.745, 0.667, 0.2%, 0.635, 0.629; Gly, Gln, Tyr, Val, Lys, 0.745, 0.722, 5.3%, 0.698, 0.722; His, Arg, Lys, Ile, Trp, 0.745, 0.680, 2.0%, 0.664, 0.671; His, Arg, Tyr, Orn, Ile, 0.745, 0.716, 3.5%, 0.730, 0.724; His, Cit, Tyr, Ile, Trp, 0.745, 0.721, 3.5%, 0.723, 0.738; Pro, Tyr, Met, Leu, Phe, 0.745, 0.715, 4.6%, 0.705, 0.641; Ser, Arg, Orn, Lys, Ile, 0.745, 0.657, 1.3%, 0.641, 0.671; Ser, Asn, Gly, Tyr, Leu, 0.745, 0.717, 2.8%, 0.697, 0.629; Ser, Cit, Tyr, Ile, Trp, 0.745, 0.709, 5.9%, 0.707, 0.734; Ser, Gln, His, Lys, Ile, 0.745, 0.682, 0.9%, 0.672, 0.714; Ser, Gln, His, Met, Ile, 0.745, 0.689, 0.7%, 0.703, 0.712; Ser, Gln, Pro, Tyr, Ile, 0.745, 0.713, 4.8%, 0.723, 0.763; Ser, Gln, Tyr, Met, Ile, 0.745, 0.713, 5.9%, 0.718, 0.736; Ser, Tyr, Met, Lys, Ile, 0.745, 0.708, 5.9%, 0.689, 0.714; Thr, Tyr, Orn, Leu, Phe, 0.745, 0.714, 2.9%, 0.710, 0.653; Tyr, Lys, Ile, Phe, Trp, 0.745, 0.702, 6.4%, 0.683, 0.671; Tyr, Met, Ile, Phe, Trp, 0.745, 0.719, 7.9%, 0.712, 0.667; Tyr, Met, Lys, Ile, Trp, 0.745, 0.711, 6.1%, 0.689, 0.706; Ala, Arg, Met, Lys, Ile, 0.744, 0.672, 2.2%, 0.662, 0.690; Arg, Tyr, Val, Met, Lys, 0.744, 0.724, 4.4%, 0.705, 0.706; Asn, Gln, Arg, Ile, Leu, 0.744, 0.701, 0.4%, 0.708, 0.653; Asn, Gln, Tyr, Val, Leu, 0.744, 0.727, 2.9%, 0.720, 0.696; Asn, Gln, Val, Ile, Leu, 0.744, 0.696, 0.2%, 0.698, 0.647; Asn, Gly, His, Val, Lys, 0.744, 0.688, 1.5%, 0.671, 0.625; Asn, His, Ala, Orn, Ile, 0.744, 0.690, 2.6%, 0.690, 0.639; Asn, His, Thr, Met, Ile, 0.744, 0.697, 1.7%, 0.696, 0.615; Asn, His, Val, Lys, Ile, 0.744, 0.679, 4.6%, 0.661, 0.663; Asn, Pro, Met, Lys, Ile, 0.744, 0.673, 3.7%, 0.642, 0.665; Asn, Tyr, Met, Ile, Phe, 0.744, 0.722, 7.4%, 0.717, 0.659; Gln, Ala, Lys, Leu, Phe, 0.744, 0.675, 0.2%, 0.660, 0.623; Gln, Ala, Tyr, Met, Ile, 0.744, 0.731, 6.1%, 0.737, 0.738; Gln, Arg, Tyr, Lys, Leu, 0.744, 0.721, 2.0%, 0.718, 0.732; Gln, Cit, Arg, Pro, Ile, 0.744, 0.700, 0.9%, 0.709, 0.696; Gln, Cit, Tyr, Ile, Leu, 0.744, 0.727, 3.1%, 0.741, 0.753; Gln, His, Ala, Leu, Trp, 0.744, 0.693, 1.5%, 0.689, 0.661; Gln, His, Arg, Tyr, Val, 0.744, 0.730, 2.0%, 0.733, 0.744; Gln, His, Tyr, Orn, Phe, 0.744, 0.720, 0.9%, 0.745, 0.755; Gln, Orn, Lys, Ile, Leu, 0.744, 0.681, 1.1%, 0.656, 0.696; Gln, Thr, Val, Leu, Phe, 0.744, 0.680, 0.0%, 0.666, 0.617; Gln, Tyr, Val, Met, Lys, 0.744, 0.728, 4.4%, 0.708, 0.724; Gln, Val, Lys, Leu, Phe, 0.744, 0.678, 0.0%, 0.649, 0.619; Gly, Gln, Cit, Arg, Ile, 0.744, 0.688, 0.7%, 0.690, 0.677; Gly, Gln, Cit, Ile, Phe, 0.744, 0.684, 0.7%, 0.692, 0.651; Gly, Gln, Tyr, Val, Trp, 0.744, 0.728, 8.6%, 0.703, 0.700; Gly, Tyr, Met, Lys, Ile, 0.744, 0.709, 5.9%, 0.685, 0.704; His, Ala, Cit, Tyr, Ile, 0.744, 0.713, 2.9%, 0.723, 0.750; His, Arg, Orn, Ile, Phe, 0.744, 0.677, 0.4%, 0.679, 0.631; His, Cit, Tyr, Orn, Ile, 0.744, 0.697, 3.1%, 0.708, 0.744; Ser, Ala, Arg, Lys, Ile, 0.744, 0.657, 0.9%, 0.639, 0.677; Ser, Asn, His, Met, Ile, 0.744, 0.676, 1.7%, 0.678, 0.643; Ser, Asn, Lys, Ile, Phe, 0.744, 0.655, 3.5%, 0.620, 0.637; Ser, Asn, Thr, Lys

, Ile, 0.744, 0.652, 2.8%, 0.620, 0.659; Ser, Cit, Tyr, Ile, Phe, 0.744, 0.713, 5.0%, 0.723, 0.708; Ser, Gln, Ala, Tyr, Ile, 0.744, 0.712, 5.3%, 0.720, 0.757; Ser, Gln, Lys, Leu, Trp, 0.744, 0.674, 0.2%, 0.640, 0.645; Ser, Gln, Orn, Lys, Ile, 0.744, 0.663, 1.1%, 0.640, 0.710; Ser, Tyr, Met, Ile, Phe, 0.744, 0.714, 6.8%, 0.708, 0.665; Arg, Pro, Lys, Ile, Phe, 0.743, 0.665, 1.1%, 0.650, 0.635; Asn, Gln, Ala, Cit, Ile, 0.743, 0.692, 0.6%, 0.708, 0.690; Asn, Gly, Val, Lys, Ile, 0.743, 0.672, 2.8%, 0.645, 0.655; Asn, Val, Orn, Lys, Ile, 0.743, 0.678, 2.2%, 0.655, 0.665; Cit, Tyr, Ile, Phe, Trp, 0.743, 0.714, 5.3%, 0.719, 0.698; Gln, Arg, Pro, Tyr, Ile, 0.743, 0.729, 5.5%, 0.743, 0.753; Gln, Arg, Tyr, Orn, Ile, 0.743, 0.723, 5.9%, 0.740, 0.753; Gln, His, Pro, Orn, Ile, 0.743, 0.693, 1.7%, 0.710, 0.708; Gly, Gln, Tyr, Val, Met, 0.743, 0.729, 8.1%, 0.710, 0.692; Gly, Tyr, Lys, Ile, Phe, 0.743, 0.701, 6.1%, 0.681, 0.667; Pro, Tyr, Lys, Ile, Phe, 0.743, 0.703, 6.1%, 0.685, 0.673; Pro, Tyr, Met, Lys, Ile, 0.743, 0.708, 6.6%, 0.688, 0.700; Ser, Cit, Tyr, Val, Ile, 0.743, 0.715, 5.3%, 0.714, 0.730; Ser, Gln, His, Val, Ile, 0.743, 0.690, 1.1%, 0.709, 0.736; Arg, Tyr, Leu, Phe, Trp, 0.743, 0.719, 2.4%, 0.710, 0.653; Asn, Arg, Orn, Lys, Leu, 0.743, 0.659, 1.1%, 0.638, 0.602; Asn, Gln, Ala, Ile, Leu, 0.743, 0.692, 0.4%, 0.695, 0.655; Asn, Gln, Ala, Tyr, Ile, 0.743, 0.727, 6.4%, 0.733, 0.722; Asn, Gln, Arg, Leu, Phe, 0.743, 0.683, 0.0%, 0.675, 0.592; Asn, Gln, Cit, Ile, Leu, 0.743, 0.700, 0.2%, 0.706, 0.659; Asn, Gln, Cit, Val, Ile, 0.743, 0.700, 0.2%, 0.710, 0.684; Asn, Gln, Tyr, Orn, Ile, 0.743, 0.725, 6.4%, 0.730, 0.716; Asn, Gly, Gln, Leu, Phe, 0.743, 0.677, 0.0%, 0.659, 0.580; Asn, Gly, His, Tyr, Val, 0.743, 0.722, 5.0%, 0.699, 0.667; Asn, Gly, Tyr, Met, Ile, 0.743, 0.719, 8.1%, 0.708, 0.675; Asn, His, Orn, Ile, Trp, 0.743, 0.688, 1.3%, 0.689, 0.631; Asn, His, Tyr, Lys, Leu, 0.743, 0.714, 3.3%, 0.695, 0.663; Asn, Orn, Lys, Ile, Trp, 0.743, 0.675, 2.0%, 0.655, 0.667; Cit, Pro, Tyr, Met, Ile, 0.743, 0.724, 5.1%, 0.723, 0.710; Gln, Ala, Cit, Orn, Ile, 0.743, 0.679, 2.0%, 0.683, 0.690; Gln, Cit, Orn, Ile, Leu, 0.743, 0.682, 2.2%, 0.682, 0.653; Gln, Cit, Val, Ile, Leu, 0.743, 0.699, 0.2%, 0.703, 0.665; Gln, His, Orn, Lys, Leu, 0.743, 0.683, 1.1%, 0.663, 0.651; Gln, His, Pro, Tyr, Val, 0.743, 0.727, 4.0%, 0.726, 0.744; Gln, His, Tyr, Val, Met, 0.743, 0.736, 2.2%, 0.730, 0.718; Gln, His, Tyr, Val, Phe, 0.743, 0.735, 1.8%, 0.734, 0.698; Gln, Pro, Lys, Ile, Trp, 0.743, 0.677, 1.1%, 0.653, 0.694; Gln, Thr, Cit, Lys, Ile, 0.743, 0.684, 0.7%, 0.671, 0.724; Gln, Thr, Tyr, Lys, Ile, 0.743, 0.720, 5.3%, 0.720, 0.753; Gln, Tyr, Val, Met, Ile, 0.743, 0.731, 6.2%, 0.732, 0.726; Gly, Tyr, Leu, Phe, Trp, 0.743, 0.707, 2.6%, 0.680, 0.611; His, Arg, Met, Ile, Phe, 0.743, 0.688, 0.6%, 0.685, 0.635; Pro, Tyr, Met, Ile, Phe, 0.743, 0.718, 7.5%, 0.711, 0.665; Ser, Asn, His, Val, Lys, 0.743, 0.690, 1.5%, 0.672, 0.619; Ser, Asn, Tyr, Ile, Leu, 0.743, 0.713, 4.0%, 0.703, 0.669; Ser, Asn, Tyr, Met, Leu, 0.743, 0.722, 3.5%, 0.710, 0.663; Ser, Gln, Cit, Tyr, Ile, 0.743, 0.713, 3.9%, 0.727, 0.761; Ser, Gln, Lys, Ile, Leu, 0.743, 0.662, 1.3%, 0.638, 0.704; Ser, Gln, Tyr, Orn, Ile, 0.743, 0.717, 4.8%, 0.724, 0.761; Ser, His, Arg, Tyr, Ile, 0.743, 0.710, 2.9%, 0.720, 0.732; Thr, Cit, Tyr, Leu, Phe, 0.743, 0.719, 1.7%, 0.718, 0.661; Ala, Cit, Tyr, Met, Ile, 0.743, 0.726, 5.1%, 0.726, 0.714; Asn, Ala, Lys, Ile, Leu, 0.743, 0.672, 1.8%, 0.651, 0.671; Asn, Ala, Orn, Lys, Ile, 0.743, 0.677, 2.6%, 0.654, 0.686; Asn, Arg, Pro, Tyr, Ile, 0.743, 0.725, 6.1%, 0.733, 0.704; Asn, Gln, Thr, Arg, Ile, 0.743, 0.687, 1.8%, 0.709, 0.710; Asn, Gln, Thr, Tyr, Ile, 0.743, 0.725, 6.8%, 0.733, 0.720; Asn, Gly, His, Met, Ile, 0.743, 0.692, 1.7%, 0.695, 0.609; Asn, Gly, His, Orn, Ile, 0.743, 0.688, 1.3%, 0.689, 0.627; Asn, Gly, Tyr, Lys, Ile, 0.743, 0.701, 8.1%, 0.676, 0.688; Asn, Gly, Tyr, Orn, Leu, 0.743, 0.716, 2.4%, 0.695, 0.645; Asn, His, Ala, Arg, Ile, 0.743, 0.699, 1.5%, 0.713, 0.655; Asn, His, Val, Met, Ile, 0.743, 0.696, 1.1%, 0.696, 0.611; Asn, Met, Lys, Ile, Trp, 0.743, 0.670, 2.8%, 0.647, 0.663; Asn, Pro, Orn, Lys, Ile, 0.743, 0.677, 2.8%, 0.652, 0.677; Asn, Thr, Ala, Lys, Ile, 0.743, 0.670, 3.7%, 0.647, 0.673; Cit, Arg, Orn, Lys, Ile, 0.743, 0.664, 1.7%, 0.656, 0.667; Cit, Arg, Tyr, Ile, Trp, 0.743, 0.723, 5.1%, 0.730, 0.726; Cit, Tyr, Met, Leu, Phe, 0.743, 0.721, 1.5%, 0.710, 0.657; Cit, Tyr, Val, Ile, Trp, 0.743, 0.725, 6.1%, 0.718, 0.724; Gln, Ala, Cit, Ile, Leu, 0.743, 0.692, 0.6%, 0.701, 0.684; Gln, Ala, Met, Lys, Ile, 0.743, 0.678, 0.9%, 0.661, 0.706; Gln, Arg, Tyr, Leu, Trp, 0.743, 0.727, 3.5%, 0.719, 0.712; Gln, Cit, Arg, Ile, Trp, 0.743, 0.699, 0.4%, 0.710, 0.692; Gln, Cit, Pro, Lys, Ile, 0.743, 0.680, 1.1%, 0.669, 0.708; Gln, Cit, Val, Ile, Phe, 0.743, 0.697, 0.4%, 0.708, 0.671; Gln, His, Ala, Lys, Ile, 0.743, 0.697, 0.9%, 0.696, 0.720; Gln, His, Tyr, Lys, Phe, 0.743, 0.730, 1.3%, 0.737, 0.775; Gln, His, Tyr, Val, Lys, 0.743, 0.727, 4.0%, 0.718, 0.750; Gln, Orn, Lys, Leu, Trp, 0.743, 0.674, 0.2%, 0.640, 0.633; Gln, Pro, Met, Lys, Ile, 0.743, 0.676, 0.9%, 0.653, 0.690; Gln, Pro, Val, Lys, Ile, 0.743, 0.675, 1.5%, 0.655, 0.700; Gln, Thr, Arg, Tyr, Leu, 0.743, 0.728, 2.9%, 0.730, 0.730; Gln, Thr, Cit, Ile, Leu, 0.743, 0.697, 0.6%, 0.700, 0.690; Gln, Thr, Tyr, Leu, Trp, 0.743, 0.726, 5.5%, 0.711, 0.706; Gln, Tyr, Orn, Ile, Trp, 0.743, 0.730, 6.8%, 0.732, 0.748; Gly, Cit, Tyr, Ile, Leu, 0.743, 0.703, 4.4%, 0.697, 0.702; Gly, Gln, Orn, Leu, Phe, 0.743, 0.667, 0.0%, 0.645, 0.578; Gly, His, Arg, Ile, Phe, 0.743, 0.685, 0.6%, 0.684, 0.639; Gly, Thr, Cit, Tyr, Ile, 0.743, 0.714, 6.4%, 0.716, 0.728; His, Ala, Arg, Tyr, Ile, 0.743, 0.719, 2.9%, 0.731, 0.736; His, Arg, Orn, Lys, Ile, 0.743, 0.669, 0.7%, 0.660, 0.667; His, Arg, Pro, Tyr, Ile, 0.743, 0.718, 2.9%, 0.730, 0.734; His, Tyr, Val, Ile, Phe, 0.743, 0.715, 4.0%, 0.705, 0.680; Pro, Tyr, Ile, Leu, Phe, 0.743, 0.710, 4.2%, 0.699, 0.647; Ser, Asn, His, Cit, Ile, 0.743, 0.686, 0.6%, 0.692, 0.682; Ser, Gln, Cit, Orn, Ile, 0.743, 0.667, 2.6%, 0.675, 0.700; Ser, Gly, Gln, Leu, Phe, 0.743, 0.666, 0.0%, 0.645, 0.592; Thr, Tyr, Met, Lys, Ile, 0.743, 0.711, 10.5%, 0.692, 0.710; Ala, Arg, Pro, Tyr, Lys, 0.742, 0.696, 5.5%, 0.682, 0.777; Ala, Cit, Pro, Tyr, Ile, 0.742, 0.718, 4.8%, 0.724, 0.734; Ala, Cit, Tyr, Orn, Ile, 0.742, 0.702, 4.2%, 0.709, 0.728; Arg, Met, Orn, Lys, Ile, 0.742, 0.665, 2.0%, 0.652, 0.669; Asn, Arg, Tyr, Met, Ile, 0.742, 0.726, 6.4%, 0.727, 0.694; Asn, Arg, Tyr, Val, Lys, 0.742, 0.719, 4.2%, 0.700, 0.698; Asn, Gln, Met, Leu, Phe, 0.742, 0.687, 0.0%, 0.678, 0.619; Asn, Gln, Orn, Leu, Trp, 0.742, 0.679, 0.2%, 0.664, 0.596; Asn, Gln, Val, Orn, Leu, 0.742, 0.679, 0.2%, 0.664, 0.596; Asn, Gly, Lys, Ile, Phe, 0.742, 0.674, 2.8%, 0.639, 0.643; Asn, Gly, Lys, Ile, Trp, 0.742, 0.671, 2.0%, 0.647, 0.663; Asn, Gly, Tyr, Val, Ile, 0.742, 0.721, 8.3%, 0.703, 0.673; Asn, Gly, Tyr, Val, Met, 0.742, 0.724, 9.4%, 0.697, 0.657; Asn, His, Ala, Ile, Phe, 0.742, 0.685, 0.7%, 0.689, 0.637; Asn, His, Pro, Orn, Ile, 0.742, 0.688, 1.5%, 0.690, 0.625; Asn, His, Thr, Arg, Ile, 0.742, 0.699, 1.3%, 0.709, 0.645; Asn, His, Thr, Cit, Ile, 0.742, 0.701, 0.6%, 0.708, 0.655; Asn, Orn, Lys, Leu, Phe, 0.742, 0.666, 0.6%, 0.624, 0.558; Asn, Pro, Tyr, Lys, Leu, 0.742, 0.709, 3.5%, 0.688, 0.649; Asn, Tyr, Met, Orn, Leu, 0.742, 0.719, 4.0%, 0.708, 0.661; Asn, Tyr, Val, Lys, Ile, 0.742, 0.706, 6.8%, 0.687, 0.694; Asn, Val, Lys, Ile, Trp, 0.742, 0.671, 2.0%, 0.650, 0.661; Cit, Tyr, Lys, Ile, Leu, 0.742, 0.708, 3.9%, 0.708, 0.738; Gln, Ala, Arg, Tyr, Ile, 0.742, 0.727, 5.7%, 0.742, 0.751; Gln, Ala, Cit, Met, Ile, 0.742, 0.694, 2.2%, 0.710, 0.728; Gln, Ala, Tyr, Ile, Trp, 0.742, 0.731, 7.0%, 0.733, 0.744; Gln, Ala, Tyr, Val, Leu, 0.742, 0.718, 2.6%, 0.718, 0.738; Gln, Arg, Pro, Lys, Ile, 0.742, 0.680, 2.0%, 0.677, 0.700; Gln, Arg, Tyr, Val, Ile, 0.742, 0.728, 5.3%, 0.732, 0.740; Gln, Cit, Ile, Leu, Trp, 0.742, 0.700, 0.2%, 0.700, 0.665; Gln, Cit, Tyr, Met, Ile, 0.742, 0.727, 3.1%, 0.740, 0.751; Gln, His, Ala, Lys, Phe, 0.742, 0.680, 1.3%, 0.685, 0.716; Gln, His, Ala, Orn, Ile, 0.742, 0.692, 1.7%, 0.708, 0.706; Gln, His, Arg, Orn, Leu, 0.742, 0.688, 0.2%, 0.691, 0.671; Gln, His, Arg, Tyr, Leu, 0.742, 0.726, 2.0%, 0.735, 0.736; Gln, His, Tyr, Met, Phe, 0.742, 0.735, 0.9%, 0.761, 0.755; Gln, Pro, Ile, Leu, Phe, 0.742, 0.692, 0.0%, 0.694, 0.643; Gln, Val, Lys, Leu, Trp, 0.742, 0.686, 0.2%, 0.655, 0.649; Gly, Arg, Met, Lys, Ile, 0.742, 0.669, 1.8%, 0.649, 0.671; Gly, Gln, Cit, Ile, Leu, 0.742, 0.689, 0.2%, 0.679, 0.651; Gly, Gln, Cit, Ile, Trp, 0.742, 0.687, 0.7%, 0.691, 0.682; Gly, Thr, Tyr, Leu, Phe, 0.742, 0.712, 3.1%, 0.699, 0.617; His, Thr, Lys, Ile, Phe, 0.742, 0.677, 1.1%, 0.648, 0.606; Ser, Asn, Tyr, Val, Ile, 0.742, 0.719, 8.1%, 0.706, 0.682; Ser, Asn, Val, Lys, Leu, 0.742, 0.666, 0.7%, 0.629, 0.596; Ser, Gln, Tyr, Met, Leu, 0.742, 0.725, 2.6%, 0.723, 0.710; Ser, Gly, Gln, His, Ile, 0.742, 0.691, 1.1%, 0.704, 0.720; Ser, His, Cit, Tyr, Ile, 0.742, 0.713, 2.9%, 0.723, 0.751; Ser, Tyr, Val, Ile, Phe, 0.742, 0.719, 5.9%, 0.708, 0.665; Thr, Tyr, Leu, Phe, Trp, 0.742, 0.722, 3.5%, 0.708, 0.639; Arg, Val, Orn, Lys, Ile, 0.742, 0.667, 2.0%, 0.653, 0.675; Asn, Ala, Tyr, Lys, Leu, 0.742, 0.709, 2.8%, 0.691, 0.661; Asn, Arg, Tyr, Ile, Phe, 0.742, 0.720, 5.5%, 0.725, 0.671; Asn, Cit, Tyr, Met, Leu, 0.742, 0.726, 2.8%, 0.716, 0.671; Asn, Gln, His, Ala, Leu, 0.742, 0.694, 0.4%, 0.702, 0.643; Asn, Gln, Orn, Ile, Leu, 0.742, 0.686, 1.3%, 0.682, 0.631; Asn, Gln, Thr, Ile, Leu, 0.742, 0.693, 0.7%, 0.696, 0.661; Asn, Gly, Gln, Val, Lys, 0.742, 0.678, 0.7%, 0.642, 0.613; Asn, Gly, Tyr, Val, Lys, 0.742, 0.719, 6.8%, 0.685, 0.665; Asn, His, Arg, Met, Ile, 0.742, 0.697, 1.1%, 0.706, 0.635; Asn, His, Cit, Val, Lys, 0.742, 0.689, 1.3%, 0.671, 0.621; Asn, His, Thr, Ile, Leu, 0.742, 0.697, 0.4%, 0.694, 0.617; Asn, His, Val, Lys, Trp, 0.742, 0.688, 1.7%, 0.671, 0.619; Asn, Pro, Tyr, Lys, Ile, 0.742, 0.706, 5.3%, 0.687, 0.696; Asn, Tyr, Met, Leu, Trp, 0.742, 0.726, 4.0%, 0.711, 0.663; Cit, Arg, Lys, Ile, Trp, 0.742, 0.675, 1.5%, 0.658, 0.682; Cit, Tyr, Met, Ile, Trp, 0.742, 0.723, 5.3%, 0.723, 0.718; Cit, Tyr, Val, Ile, Leu, 0.742, 0.711, 4.4%, 0.712, 0.718; Gln, Ala, Orn, Lys, Ile, 0.742, 0.679, 1.1%, 0.660,

 0.706; Gln, Cit, Arg, Ile, Phe, 0.742, 0.692, 0.7%, 0.704, 0.661; Gln, Cit, Met, Orn, Ile, 0.742, 0.684, 2.9%, 0.691, 0.708; Gln, Cit, Pro, Ile, Trp, 0.742, 0.700, 0.9%, 0.712, 0.700; Gln, Cit, Pro, Met, Ile, 0.742, 0.695, 1.7%, 0.706, 0.718; Gln, His, Tyr, Met, Orn, 0.742, 0.716, 2.4%, 0.740, 0.744; Gln, His, Tyr, Phe, Trp, 0.742, 0.734, 0.7%, 0.757, 0.759; Gln, Lys, Leu, Phe, Trp, 0.742, 0.675, 0.0%, 0.645, 0.613; Gln, Thr, Cit, Orn, Ile, 0.742, 0.678, 2.4%, 0.684, 0.696; Gln, Thr, Ile, Leu, Phe, 0.742, 0.687, 0.2%, 0.688, 0.657; Gln, Thr, Orn, Ile, Leu, 0.742, 0.688, 0.9%, 0.683, 0.675; Gln, Tyr, Met, Orn, Ile, 0.742, 0.731, 5.7%, 0.737, 0.738; Gly, Cit, Arg, Tyr, Ile, 0.742, 0.715, 3.3%, 0.719, 0.708; Gly, Gln, Cit, Val, Ile, 0.742, 0.691, 0.6%, 0.685, 0.661; Gly, Gln, His, Orn, Leu, 0.742, 0.685, 0.2%, 0.674, 0.647; Gly, Gln, His, Pro, Tyr, 0.742, 0.728, 5.5%, 0.746, 0.750; Gly, Gln, Orn, Ile, Leu, 0.742, 0.681, 0.9%, 0.672, 0.647; Gly, Gln, Val, Orn, Leu, 0.742, 0.674, 0.2%, 0.650, 0.613; Gly, Tyr, Ile, Leu, Phe, 0.742, 0.708, 4.6%, 0.689, 0.637; Gly, Tyr, Met, Ile, Phe, 0.742, 0.713, 7.4%, 0.699, 0.653; His, Cit, Pro, Tyr, Ile, 0.742, 0.712, 2.9%, 0.723, 0.748; Ser, Asn, Lys, Ile, Leu, 0.742, 0.658, 2.4%, 0.627, 0.641; Ser, Asn, Lys, Leu, Phe, 0.742, 0.665, 0.4%, 0.624, 0.562; Ser, Gln, Pro, Lys, Ile, 0.742, 0.661, 1.7%, 0.636, 0.704; Ser, Gln, Thr, Leu, Phe, 0.742, 0.672, 0.0%, 0.653, 0.615; Tyr, Met, Leu, Phe, Trp, 0.742, 0.721, 2.6%, 0.703, 0.637; Arg, Orn, Lys, Ile, Leu, 0.741, 0.665, 2.2%, 0.652, 0.663; Arg, Pro, Tyr, Met, Lys, 0.741, 0.694, 6.4%, 0.670, 0.742; Asn, Arg, Val, Orn, Lys, 0.741, 0.664, 2.2%, 0.646, 0.637; Asn, Gln, Cit, Ile, Phe, 0.741, 0.692, 0.6%, 0.705, 0.659; Asn, Gln, Cit, Leu, Phe, 0.741, 0.683, 0.0%, 0.673, 0.590; Asn, Gln, Pro, Orn, Ile, 0.741, 0.684, 2.0%, 0.695, 0.679; Asn, Gln, Thr, Orn, Leu, 0.741, 0.677, 0.2%, 0.663, 0.598; Asn, Gly, His, Ala, Ile, 0.741, 0.694, 2.2%, 0.696, 0.643; Asn, Gly, Lys, Leu, Phe, 0.741, 0.665, 0.4%, 0.623, 0.550; Asn, His, Arg, Ile, Trp, 0.741, 0.698, 1.3%, 0.706, 0.643; Asn, His, Arg, Tyr, Lys, 0.741, 0.714, 3.5%, 0.712, 0.748; Asn, His, Arg, Val, Ile, 0.741, 0.700, 1.1%, 0.708, 0.641; Asn, His, Met, Ile, Leu, 0.741, 0.696, 0.7%, 0.694, 0.611; Asn, His, Pro, Val, Ile, 0.741, 0.698, 0.9%, 0.698, 0.635; Asn, His, Thr, Tyr, Ile, 0.741, 0.726, 5.9%, 0.736, 0.702; Asn, His, Val, Ile, Trp, 0.741, 0.698, 1.1%, 0.697, 0.633; Asn, Tyr, Val, Ile, Leu, 0.741, 0.718, 3.7%, 0.711, 0.669; Asn, Val, Lys, Leu, Phe, 0.741, 0.669, 0.4%, 0.630, 0.568; Cit, Tyr, Val, Ile, Phe, 0.741, 0.718, 4.8%, 0.715, 0.692; Gln, Ala, Cit, Pro, Ile, 0.741, 0.694, 0.9%, 0.704, 0.700; Gln, Arg, Lys, Leu, Phe, 0.741, 0.674, 0.2%, 0.650, 0.633; Gln, Arg, Orn, Leu, Phe, 0.741, 0.669, 0.2%, 0.658, 0.592; Gln, Cit, Arg, Ile, Leu, 0.741, 0.699, 0.2%, 0.702, 0.669; Gln, Cit, Pro, Ile, Leu, 0.741, 0.699, 0.6%, 0.699, 0.667; Gln, Cit, Tyr, Val, Leu, 0.741, 0.724, 2.2%, 0.729, 0.742; Gln, His, Ala, Tyr, Lys, 0.741, 0.722, 4.4%, 0.725, 0.769; Gln, His, Arg, Tyr, Phe, 0.741, 0.737, 0.7%, 0.766, 0.763; Gln, His, Pro, Tyr, Lys, 0.741, 0.719, 6.1%, 0.723, 0.771; Gln, Pro, Orn, Lys, Ile, 0.741, 0.677, 1.3%, 0.655, 0.688; Gln, Thr, Ala, Lys, Ile, 0.741, 0.679, 1.1%, 0.661, 0.706; Gln, Thr, Arg, Orn, Ile, 0.741, 0.683, 1.7%, 0.703, 0.710; Gln, Thr, Leu, Phe, Trp, 0.741, 0.679, 0.0%, 0.665, 0.609; Gln, Tyr, Val, Lys, Phe, 0.741, 0.728, 4.6%, 0.710, 0.708; Gln, Tyr, Val, Orn, Leu, 0.741, 0.717, 2.8%, 0.714, 0.736; Gly, Arg, Tyr, Val, Lys, 0.741, 0.714, 3.5%, 0.696, 0.700; Gly, Gln, Arg, Leu, Phe, 0.741, 0.674, 0.0%, 0.657, 0.580; Gly, Gln, Arg, Tyr, Val, 0.741, 0.727, 4.2%, 0.712, 0.708; Gly, Gln, Cit, Met, Ile, 0.741, 0.690, 1.3%, 0.692, 0.700; Gly, Gln, Met, Orn, Leu, 0.741, 0.671, 0.2%, 0.651, 0.617; Gly, His, Lys, Ile, Phe, 0.741, 0.672, 1.3%, 0.643, 0.617; Gly, Tyr, Met, Ile, Leu, 0.741, 0.714, 6.4%, 0.694, 0.665; His, Thr, Arg, Ile, Phe, 0.741, 0.684, 0.2%, 0.682, 0.641; His, Thr, Tyr, Leu, Phe, 0.741, 0.719, 1.8%, 0.719, 0.653; Ser, Gln, Cit, Tyr, Leu, 0.741, 0.722, 2.0%, 0.727, 0.740; Ser, Gln, His, Orn, Leu, 0.741, 0.684, 0.4%, 0.677, 0.651; Ser, Gln, Tyr, Val, Leu, 0.741, 0.721, 2.8%, 0.718, 0.736; Ser, Tyr, Ile, Leu, Phe, 0.741, 0.714, 4.0%, 0.704, 0.653; Thr, Arg, Lys, Ile, Leu, 0.741, 0.677, 1.8%, 0.660, 0.680; Thr, Arg, Tyr, Leu, Phe, 0.741, 0.723, 1.7%, 0.725, 0.657; Thr, Cit, Tyr, Met, Ile, 0.741, 0.726, 5.5%, 0.726, 0.708; Thr, Cit, Tyr, Orn, Ile, 0.741, 0.702, 5.5%, 0.716, 0.726; Tyr, Met, Ile, Leu, Trp, 0.741, 0.721, 6.4%, 0.708, 0.680; Tyr, Met, Lys, Leu, Phe, 0.741, 0.719, 3.1%, 0.698, 0.645; Tyr, Orn, Lys, Ile, Phe, 0.741, 0.715, 4.4%, 0.692, 0.690; Tyr, Val, Ile, Leu, Phe, 0.741, 0.712, 4.0%, 0.702, 0.653; Ala, Tyr, Ile, Leu, Phe, 0.740, 0.707, 4.0%, 0.699, 0.657; Arg, Lys, Ile, Leu, Trp, 0.740, 0.676, 1.7%, 0.654, 0.667; Arg, Tyr, Met, Leu, Phe, 0.740, 0.721, 1.5%, 0.718, 0.663; Asn, Ala, Arg, Tyr, Ile, 0.740, 0.722, 6.2%, 0.728, 0.702; Asn, Ala, Tyr, Ile, Leu, 0.740, 0.717, 3.7%, 0.709, 0.671; Asn, Ala, Tyr, Lys, Ile, 0.740, 0.705, 7.9%, 0.682, 0.686; Asn, Ala, Tyr, Val, Ile, 0.740, 0.728, 8.3%, 0.717, 0.684; Asn, Cit, Ile, Leu, Phe, 0.740, 0.686, 0.6%, 0.681, 0.613; Asn, Gln, His, Val, Lys, 0.740, 0.693, 1.1%, 0.676, 0.655; Asn, Gln, Met, Ile, Leu, 0.740, 0.697, 0.9%, 0.702, 0.655; Asn, Gln, Met, Orn, Leu, 0.740, 0.681, 0.2%, 0.670, 0.607; Asn, Gln, Pro, Ile, Phe, 0.740, 0.687, 1.3%, 0.701, 0.673; Asn, Gln, Thr, Val, Lys, 0.740, 0.680, 0.9%, 0.650, 0.631; Asn, Gly, Gln, Ile, Leu, 0.740, 0.688, 0.7%, 0.681, 0.627; Asn, Gly, His, Arg, Ile, 0.740, 0.693, 1.3%, 0.702, 0.633; Asn, Gly, Ile, Leu, Phe, 0.740, 0.675, 0.6%, 0.664, 0.580; Asn, Gly, Pro, Lys, Ile, 0.740, 0.668, 3.1%, 0.637, 0.671; Asn, His, Arg, Pro, Ile, 0.740, 0.697, 1.5%, 0.708, 0.647; Asn, His, Cit, Ile, Leu, 0.740, 0.702, 0.4%, 0.706, 0.635; Asn, His, Thr, Val, Ile, 0.740, 0.699, 0.9%, 0.699, 0.623; Asn, Met, Lys, Leu, Phe, 0.740, 0.669, 0.4%, 0.635, 0.572; Asn, Pro, Tyr, Ile, Leu, 0.740, 0.720, 4.8%, 0.714, 0.665; Asn, Pro, Tyr, Met, Leu, 0.740, 0.722, 2.9%, 0.712, 0.661; Asn, Pro, Val, Lys, Ile, 0.740, 0.670, 3.1%, 0.640, 0.669; Asn, Thr, Pro, Tyr, Leu, 0.740, 0.722, 3.7%, 0.715, 0.663; Asn, Tyr, Lys, Ile, Trp, 0.740, 0.703, 7.7%, 0.678, 0.688; Asn, Tyr, Orn, Lys, Ile, 0.740, 0.715, 5.9%, 0.694, 0.708; Asn, Tyr, Val, Lys, Leu, 0.740, 0.713, 3.3%, 0.689, 0.661; Asn, Tyr, Val, Met, Leu, 0.740, 0.725, 4.2%, 0.713, 0.663; Cit, Pro, Tyr, Ile, Phe, 0.740, 0.711, 4.8%, 0.721, 0.700; Cit, Tyr, Val, Lys, Ile, 0.740, 0.708, 4.6%, 0.703, 0.736; Gln, Ala, Lys, Ile, Leu, 0.740, 0.680, 0.9%, 0.664, 0.702; Gln, Arg, Tyr, Met, Leu, 0.740, 0.726, 2.4%, 0.726, 0.708; Gln, Cit, Met, Ile, Trp, 0.740, 0.699, 1.7%, 0.708, 0.718; Gln, Cit, Pro, Ile, Phe, 0.740, 0.693, 0.7%, 0.702, 0.655; Gln, His, Ala, Orn, Leu, 0.740, 0.680, 1.3%, 0.679, 0.661; Gln, His, Thr, Tyr, Leu, 0.740, 0.726, 2.6%, 0.734, 0.734; Gln, His, Tyr, Lys, Trp, 0.740, 0.726, 2.8%, 0.727, 0.777; Gln, Pro, Lys, Ile, Phe, 0.740, 0.670, 0.6%, 0.643, 0.641; Gln, Pro, Orn, Ile, Leu, 0.740, 0.687, 1.5%, 0.686, 0.669; Gln, Thr, Lys, Leu, Trp, 0.740, 0.684, 0.2%, 0.655, 0.649; Gln, Val, Orn, Ile, Leu, 0.740, 0.685, 0.7%, 0.681, 0.659; Gly, Arg, Orn, Lys, Ile, 0.740, 0.664, 1.3%, 0.646, 0.663; Gly, Gln, Ala, Tyr, Val, 0.740, 0.725, 7.7%, 0.707, 0.710; Gly, Gln, His, Leu, Phe, 0.740, 0.691, 0.0%, 0.682, 0.619; Gly, Gln, His, Tyr, Lys, 0.740, 0.724, 4.0%, 0.724, 0.769; Gly, Gln, Lys, Leu, Trp, 0.740, 0.675, 0.2%, 0.637, 0.619; Gly, Gln, Orn, Leu, Trp, 0.740, 0.673, 0.4%, 0.647, 0.600; His, Cit, Tyr, Ile, Leu, 0.740, 0.714, 3.1%, 0.721, 0.736; His, Tyr, Met, Leu, Phe, 0.740, 0.719, 2.6%, 0.707, 0.641; Ser, Asn, Gln, Thr, Leu, 0.740, 0.677, 0.2%, 0.662, 0.621; Ser, Asn, Gln, Val, Lys, 0.740, 0.677, 0.6%, 0.644, 0.631; Ser, Asn, His, Ala, Ile, 0.740, 0.677, 2.9%, 0.678, 0.669; Ser, Gln, Ala, Tyr, Leu, 0.740, 0.714, 2.6%, 0.714, 0.732; Ser, Gln, Orn, Leu, Phe, 0.740, 0.665, 0.0%, 0.645, 0.598; Ser, Thr, Arg, Lys, Ile, 0.740, 0.653, 1.3%, 0.632, 0.669; Ser, Tyr, Lys, Ile, Phe, 0.740, 0.705, 6.1%, 0.686, 0.671; Thr, Arg, Orn, Lys, Ile, 0.740, 0.666, 2.4%, 0.654, 0.675; Tyr, Lys, Leu, Phe, Trp, 0.740, 0.709, 2.6%, 0.679, 0.619; Tyr, Met, Orn, Lys, Ile, 0.740, 0.719, 6.1%, 0.698, 0.712; Tyr, Orn, Leu, Phe, Trp, 0.740, 0.713, 2.6%, 0.692, 0.625 [9. Five-variable formula including amino acids]
Arg, Tyr, Lys, Ile, Phe, 0.776, 0.721, 2.9%, 0.723, 0.726; Gln, His, Tyr, Ile, Phe, 0.774, 0.735, 2.2%, 0.756, 0.734; Phe, 0.771, 0.724, 5.5%, 0.719, 0.726; Asn, Arg, Tyr, Lys, Ile, 0.770, 0.717, 5.3%, 0.715, 0.730; Gln, His, Cit, Ile, Phe, 0.770, 0.712, 0.0% , 0.733, 0.692; Asn, Gln, His, Ile, Phe, 0.769, 0.709, 0.0%, 0.738, 0.673; Gln, His, Arg, Tyr, Ile, 0.769, 0.736, 2.4%, 0.762, 0.789; Ser, Gln Asn, Gln, Tyr, Leu, Phe, 0.768, 0.737, 2.2%, 0.737, 0.679; Gln, His, Tyr, Ile, Trp, 0.768 Gln, Tyr, Ile, Leu, Phe, 0.768, 0.729, 2.9%, 0.734, 0.698; Asn, Gln, His, Cit, Ile, 0.767, 0.717, 0.7%, 0.742, 0.724; Asn, Gln, His, Tyr, Ile, 0.766, 0.737, 3.9%, 0.759, 0.761; Gln, His, Cit, Orn, Ile, 0.766, 0.697, 0.9%, 0.711, 0.720; Pro, Ile, 0.766, 0.712, 1.1%, 0.735, 0.736; Asn, Gln, His, Ala, Ile, 0.765, 0.712, 1.7%, 0.735, 0.712; Gln, Arg, Lys, Ile, Phe, 0.765, 0.684, 1.1%, 0.682, 0.69 2; Gln, His, Tyr, Orn, Ile, 0.765, 0.727, 2.4%, 0.750, 0.777; Gln, His, Tyr, Val, Ile, 0.765, 0.731, 2.4%, 0.753, 0.773; Leu, Phe, 0.765, 0.723, 2.6%, 0.715, 0.682; Gln, His, Arg, Ile, Phe, 0.764, 0.707, 0.0%, 0.730, 0.679; Gln, His, Ile, Leu, Phe, 0.764, 0.709, 0.0%, 0.730, 0.682; Asn, Gly, Gln, Tyr, Ile, 0.764, 0.724, 6.8%, 0.727, 0.724; Asn, His, Cit, Tyr, Ile, 0.764, 0.728, 3.7%, 0.743, 0.732; , His, Tyr, Met, Ile, 0.764, 0.741, 5.7%, 0.757, 0.748; Gln, Tyr, Met, Ile, Phe, 0.764, 0.730, 6.1%, 0.741, 0.704; , 0.764, 0.707, 3.9%, 0.704, 0.738; Gln, Arg, Lys, Ile, Trp, 0.763, 0.687, 0.9%, 0.682, 0.728; Gln, His, Cit, Tyr, Ile, 0.763, 0.736, 2.6%, 0.761, 0.797; Gln, His, Ile, Phe, Trp, 0.763, 0.708, 0.2%, 0.730, 0.688; Gln, His, Tyr, Ile, Leu, 0.763, 0.731, 2.4%, 0.753, 0.769; Arg, Tyr, Met, Lys, Ile, 0.763, 0.721, 4.8%, 0.718, 0.742; Asn, Gln, Tyr, Ile, Phe, 0.763, 0.730, 6.2%, 0.742, 0 Asn, Gly, Cit, Tyr, Ile, 0.763, 0.724, 6.6%, 0.726, 0.716; Gln, His, Ala, Tyr, Ile, 0.763, 0.732, 2.6%, 0.753, 0.775; Gln, His, Pro , Tyr, Ile, 0.763, 0.732, 2.6%, 0.752, 0.777; Gln, Tyr, Leu, Phe, Trp, 0.763, 0.733, 2.6%, 0.728, 0.684; , 5.7%, 0.725, 0.708; Asn, Gln, His, Orn, Ile, 0.762, 0.698, 2.4%, 0.720, 0.696; Asn, Gln, His, Pro, Ile, 0.762, 0.711, 1.7%, 0.735, 0.720; Gln, Ala, Tyr, Ile, Phe, 0.762, 0.727, 6.1%, 0.738, 0.706; Gln, His, Ala, Cit, Ile, 0.762, 0.712, 0.9%, 0.735, 0.742; Gln, Thr, Tyr, Ile, Phe, 0.762, 0.730, 6.4%, 0.744, 0.708; Gln, Tyr, Ile, Phe, Trp, 0.762, 0.729, 6.6%, 0.739, 0.706; Asn, Arg, Lys, Ile, Phe, 0.761, 0.676, 2.0% , 0.670, 0.669; Asn, Cit, Tyr, Lys, Ile, 0.761, 0.712, 5.7%, 0.708, 0.728; Asn, Gln, His, Arg, Ile, 0.761, 0.714, 1.1%, 0.738, 0.722; , Cit, Lys, Ile, 0.761, 0.682, 1.5%, 0.664, 0.671; Gln, Tyr, Val, Ile, Phe, 0.761, 0.731, 5.7%, 0.735, 0.700; , 0.725, 2.2%, 0.721 Ser, Gln, His, Tyr, Ile, 0.761, 0.726, 2.8%, 0.748, 0.773; Asn, Gln, Arg, Lys, Ile, 0.761, 0.681, 2.2%, 0.677, 0.702; Asn, Gly, Gln, Lys, Ile, 0.761, 0.679, 2.0%, 0.653, 0.665; Gln, His, Thr, Tyr, Ile, 0.761, 0.736 , 3.5%, 0.757, 0.775; Gln, His, Val, Ile, Phe, 0.761, 0.706, 0.0%, 0.728, 0.684; Gln, Pro, Tyr, Ile, Phe, 0.761, 0.729, 5.3%, 0.743, 0.708; Gly, Gln, Arg, Lys, Ile, 0.761, 0.679, 1.1%, 0.669, 0.702; His, Arg, Tyr, Ile, Phe, 0.761, 0.722, 3.3%, 0.733, 0.694; Ser, Arg, Tyr, Lys, Ile, 0.761, 0.707, 3.3%, 0.703, 0.753; Asn, Arg, Orn, Lys, Ile, 0.760, 0.666, 2.8%, 0.661, 0.669; Asn, Arg, Pro, Tyr, Lys, 0.760, 0.705, 6.8% , 0.690, 0.744; Asn, Gln, His, Ile, Leu, 0.760, 0.714, 1.1%, 0.735, 0.716; Gln, Arg, Orn, Lys, Ile, 0.760, 0.681, 1.1%, 0.678, 0.712; , Cit, Ile, Trp, 0.760, 0.714, 0.9%, 0.730, 0.712; Gln, His, Tyr, Leu, Phe, 0.760, 0.734, 1.5%, 0.740, 0.712; Gln, Tyr, Orn, Ile, Phe, 0.760 , 0.732, 5.7%, 0. 742, 0.704; Gly, Gln, Tyr, Lys, Ile, 0.760, 0.713, 4.4%, 0.701, 0.740; His, Tyr, Met, Lys, Ile, 0.760, 0.724, 6.2%, 0.710, 0.708; His, Met, Ile, 0.759, 0.713, 0.9%, 0.735, 0.714; Asn, Gln, Lys, Ile, Phe, 0.759, 0.680, 1.3%, 0.659, 0.645; Asn, Gly, Arg, Lys, Ile, 0.759, Asn, Gly, Gln, Lys, Leu, 0.759, 0.678, 0.2%, 0.641, 0.600; Gln, His, Cit, Arg, Ile, 0.759, 0.711, 0.7%, 0.734, 0.730 Gln, His, Cit, Ile, Leu, 0.759, 0.712, 0.7%, 0.737, 0.738; Gln, His, Met, Ile, Phe, 0.759, 0.707, 0.2%, 0.728, 0.686; Tyr, Met, Lys, Ile , Phe, 0.759, 0.718, 7.5%, 0.700, 0.682; Asn, Gln, His, Tyr, Leu, 0.759, 0.734, 1.1%, 0.738, 0.722; Asn, Gln, Lys, Leu, Phe, 0.759, 0.678, 0.0 %, 0.648, 0.607; Gln, Arg, Val, Lys, Ile, 0.759, 0.684, 1.3%, 0.686, 0.742; Gln, Cit, Arg, Lys, Ile, 0.759, 0.686, 0.9%, 0.687, 0.730; His, Ala, Ile, Trp, 0.759, 0.710, 1.8%, 0.728, 0.718; Gln, His, Cit, Val, Ile, 0.759, 0.711, 0.7%, 0.736, 0.730; Gln, His, Tyr, Lys, Leu, 0.759, 0.724, 3.5%, Ser, Asn, Arg, Lys, Ile, 0.759, 0.659, 2.9%, 0.647, 0.682; Asn, Cit, Pro, Lys, Ile, 0.758, 0.680, 1.8%, 0.665, 0.686; Asn, Gln, His, Lys, Ile, 0.758, 0.698, 2.6%, 0.692, 0.684; Asn, Gly, Gln, His, Ile, 0.758, 0.704, 1.3%, 0.726, 0.698; Asn, Tyr, Met, Lys, Ile, 0.758, Cit, Tyr, Lys, Ile, Trp, 0.758, 0.714, 5.7%, 0.703, 0.742; Gln, His, Ala, Met, Ile, 0.758, 0.708, 0.6%, 0.726, 0.718 Gln, His, Cit, Met, Ile, 0.758, 0.711, 0.7%, 0.732, 0.722; Gln, Tyr, Lys, Leu, Phe, 0.758, 0.723, 1.5%, 0.718, 0.700; Gln, Tyr, Orn, Leu , Phe, 0.758, 0.721, 2.0%, 0.723, 0.680; Gly, Gln, His, Ile, Phe, 0.758, 0.700, 0.2%, 0.722, 0.679; Gly, Gln, Tyr, Ile, Leu, 0.758, 0.722, 3.5 %, 0.720, 0.724; His, Arg, Tyr, Lys, Ile, 0.758, 0.711, 2.8%, 0.712, 0.742; Ser, Gly, Gln, Tyr, Ile, 0.758, 0.714, 5.5%, 0.718, 0.740; Pro, Tyr, Lys, Ile, 0.757, 0.709, 4.8%, 0.708, 0.748; Gln, His, Ala, Ile, Phe, 0.757, 0.699, 0.4%, 0.715, 0.684; Ser, His, Tyr, Ile, Phe, 0.757, 0.715, 3. 5%, 0.713, 0.684; Arg, Tyr, Lys, Ile, Trp, 0.757, 0.714, 7.4%, 0.702, 0.726; Asn, His, Lys, Ile, Phe, 0.757, 0.687, 1.7%, 0.667, 0.625; , His, Tyr, Leu, Trp, 0.757, 0.734, 3.5%, 0.727, 0.714; Gln, His, Val, Met, Ile, 0.757, 0.710, 0.6%, 0.731, 0.724; , 0.757, 0.668, 0.2%, 0.658, 0.722; Asn, Arg, Lys, Ile, Leu, 0.757, 0.675, 2.0%, 0.668, 0.679; Asn, Arg, Lys, Ile, Trp, 0.757, 0.674, 2.2%, Asn, Cit, Arg, Lys, Ile, 0.757, 0.675, 2.0%, 0.670, 0.692; Asn, Cit, Lys, Ile, Leu, 0.757, 0.682, 1.5%, 0.670, 0.675; Asn, Gln, His, Ile, Trp, 0.757, 0.709, 1.5%, 0.730, 0.710; Asn, Gly, Gln, Tyr, Leu, 0.757, 0.725, 3.7%, 0.715, 0.675; Asn, His, Arg, Tyr, Ile, 0.757, Asn, His, Cit, Lys, Ile, 0.757, 0.694, 3.9%, 0.689, 0.671; Asn, Thr, Tyr, Leu, Phe, 0.757, 0.730, 3.1%, 0.725, 0.657 Cit, Arg, Tyr, Lys, Ile, 0.757, 0.713, 2.6%, 0.715, 0.748; Gln, His, Arg, Pro, Ile, 0.757, 0.708, 0.9%, 0.735, 0.730; Gln, His, Thr, Cit , Ile, 0.757, 0.710, 0.7%, 0.733, 0.744; Gln, Pro, Tyr, Leu, Phe, 0.757, 0.726, 2.2%, 0.725, 0.682; Gln, Thr, Arg, Lys, Ile, 0.757, 0.687, 1.1%, 0.685, 0.720; Gln, Tyr, Ile, Leu, Trp, 0.757, 0.734, 5.9%, 0.728, 0.726; Gly, Gln, His, Cit, Ile Gly, Gln, Tyr, Met, Ile, 0.757, 0.728, 5.5%, 0.724, 0.722; Arg, Tyr, Ile, Leu, Phe, 0.756, 0.720, 2.8%, Arg, Tyr, Orn, Lys, Ile, 0.756, 0.708, 4.2%, 0.708, 0.740; Asn, Cit, Orn, Lys, Ile, 0.756, 0.672, 2.0%, 0.660, 0.667; Asn, Cit, Tyr, Ile, Phe, 0.756, 0.726, 4.8%, 0.734, 0.684; Asn, Gln, Thr, Leu, Phe, 0.756, 0.683, 0.0%, 0.672, 0.613; Asn, Gln, Val, Lys, Ile, 0.756, Gln, Cit, Ile, Leu, Phe, 0.756, 0.695, 0.2%, 0.703, 0.651; Gln, Cit, Tyr, Ile, Phe, 0.756, 0.729, 3.7%, 0.749, 0.728 Gln, His, Arg, Orn, Ile, 0.756, 0.696, 0.9%, 0.721, 0.710; Gln, His, Orn, Ile, Phe, 0.756, 0.692, 0.4%, 0.711, 0.675; Gln, Tyr, Met, Leu , Phe, 0.756, 0.7 30, 1.7%, 0.731, 0.675; Gln, Tyr, Met, Lys, Ile, 0.756, 0.724, 5.0%, 0.718, 0.746; His, Tyr, Met, Ile, Phe, 0.756, 0.726, 2.4%, 0.724, 0.673 Asn, Gln, Cit, Lys, Ile, 0.756, 0.685, 1.5%, 0.674, 0.690; Asn, Gln, His, Thr, Ile, 0.756, 0.710, 1.7%, 0.734, 0.726; Asn, Gln, Lys, Ile , Leu, 0.756, 0.682, 1.1%, 0.661, 0.671; Asn, Gln, Tyr, Ile, Leu, 0.756, 0.725, 3.5%, 0.729, 0.704; Asn, Gln, Tyr, Lys, Leu, 0.756, 0.727, 2.6 %, 0.715, 0.712; Asn, Lys, Ile, Leu, Phe, 0.756, 0.680, 1.5%, 0.649, 0.629; Asn, Tyr, Lys, Leu, Phe, 0.756, 0.721, 1.8%, 0.700, 0.641; His, Lys, Ile, Phe, 0.756, 0.697, 0.6%, 0.695, 0.669; Gly, Gln, Lys, Ile, Phe, 0.756, 0.672, 0.7%, 0.642, 0.653; Arg, Tyr, Val, Lys, Ile, Asn, Arg, Val, Lys, Ile, 0.755, 0.670, 2.9%, 0.663, 0.686; Asn, Thr, Arg, Lys, Ile, 0.755, 0.675, 2.2%, 0.670 , 0.686; Gln, His, Ala, Arg, Ile, 0.755, 0.707, 0.9%, 0.735, 0.730; Gln, His, Tyr, Lys, Ile, 0.755, 0.722, 3.3%, 0.729, 0.769; , Tyr, Ile, 0.755, Gly, Gln, Tyr, Lys, Leu, 0.755, 0.720, 3.5%, 0.700, 0.716; His, Thr, Tyr, Ile, Phe, 0.755, 0.724, 3.1%, 0.731, 0.677 His, Tyr, Ile, Leu, Phe, 0.755, 0.711, 2.6%, 0.702, 0.661; Ser, Asn, Gln, His, Ile, 0.755, 0.694, 0.4%, 0.715, 0.720; Thr, Arg, Tyr, Lys , Ile, 0.755, 0.715, 7.5%, 0.716, 0.748; Asn, Cit, Tyr, Orn, Ile, 0.754, 0.714, 4.4%, 0.726, 0.728; Asn, Gln, His, Orn, Leu, 0.754, 0.692, 0.9 %, 0.692, 0.637; Asn, Gln, Ile, Leu, Phe, 0.754, 0.696, 0.0%, 0.700, 0.629; Asn, Gln, Tyr, Lys, Ile, 0.754, 0.718, 6.8%, 0.710, 0.712; His, Tyr, Ile, Leu, 0.754, 0.724, 5.3%, 0.722, 0.684; Asn, His, Tyr, Met, Ile, 0.754, 0.734, 4.2%, 0.740, 0.706; Asn, Thr, Lys, Ile, Leu, 0.754, 0.680, 1.7%, 0.655, 0.661; Gln, His, Arg, Lys, Ile, 0.754, 0.699, 0.7%, 0.709, 0.710; Gln, His, Arg, Val, Ile, 0.754, 0.709, 0.4%, 0.734 , 0.726; Gln, His, Met, Ile, Leu, 0.754, 0.709, 0.6%, 0.727, 0.716; Gln, His, Thr, Ile, Phe, 0.754, 0.701, 0.4%, 0.721, 0.690; , Val, Trp, 0.75 4, 0.736, 4.6%, 0.728, 0.734; His, Ala, Tyr, Ile, Phe, 0.754, 0.705, 3.1%, 0.702, 0.680; His, Cit, Tyr, Met, Ile, 0.754, 0.727, 3.3%, 0.731 , 0.732; His, Tyr, Met, Ile, Trp, 0.754, 0.727, 4.8%, 0.725, 0.696; Ser, Asn, Gln, Lys, Ile, 0.754, 0.

662, 2.6%, 0.637, 0.679; Ser, Gln, Tyr, Leu, Trp, 0.754, 0.723, 4.6%, 0.709, 0.712; Arg, Tyr, Lys, Ile, Leu, 0.754, 0.710, 3.3%, 0.705, 0.738 Asn, Gln, Ala, Lys, Ile, 0.754, 0.679, 2.0%, 0.663, 0.686; Asn, Gln, Orn, Lys, Ile, 0.754, 0.676, 2.0%, 0.654, 0.677; Asn, Gln, Orn, Lys , Leu, 0.754, 0.671, 0.2%, 0.642, 0.607; Asn, Gln, Thr, Lys, Leu, 0.754, 0.680, 0.2%, 0.650, 0.621; Asn, Gln, Tyr, Leu, Trp, 0.754, 0.731, 5.0 %, 0.720, 0.698; Asn, His, Tyr, Ile, Phe, 0.754, 0.721, 3.1%, 0.728, 0.671; Asn, Thr, Cit, Lys, Ile, 0.754, 0.680, 1.8%, 0.669, 0.682; Tyr, Ile, Leu, Phe, 0.754, 0.724, 3.5%, 0.715, 0.663; Asn, Tyr, Met, Leu, Phe, 0.754, 0.728, 2.6%, 0.716, 0.645; Gln, Arg, Lys, Ile, Leu, Gln, Cit, Lys, Ile, Phe, 0.754, 0.681, 0.6%, 0.668, 0.673; Gln, Cit, Tyr, Orn, Ile, 0.754, 0.710, 3.3%, 0.728 , 0.742; Gln, His, Ala, Tyr, Leu, 0.754, 0.725, 2.0%, 0.730, 0.750; Gln, His, Met, Ile, Trp, 0.754, 0.709, 1.1%, 0.725, 0.706; , Tyr, Ile, 0.754, 0.727, 6.1%, 0.728, 0.734; Gly, Gln, His, Tyr, Ile, 0.754, 0.726, 3.1%, 0.742, 0.757; Gly, Gln, Tyr, Ile, Trp, 0.754, 0.722, 6.4%, 0.720, 0.728 His, Pro, Tyr, Ile, Phe, 0.754, 0.710, 3.7%, 0.705, 0.684; Ser, Gln, His, Ile, Phe, 0.754, 0.690, 0.4%, 0.707, 0.684; Ser, Gln, Tyr, Lys Ala, Arg, Tyr, Lys, Ile, 0.753, 0.709, 3.9%, 0.707, 0.742; Asn, Arg, Met, Lys, Ile, 0.753, 0.674, 1.8 %, 0.668, 0.686; Asn, Arg, Tyr, Lys, Leu, 0.753, 0.719, 3.3%, 0.710, 0.690; Asn, Cit, Val, Lys, Ile, 0.753, 0.681, 1.8%, 0.668, 0.682; Gln, Lys, Ile, Trp, 0.753, 0.679, 1.3%, 0.657, 0.677; Gln, Ala, Arg, Lys, Ile, 0.753, 0.685, 1.1%, 0.687, 0.726; Gln, Arg, Met, Lys, Ile, 0.753, 0.684, 1.3%, 0.682, 0.726; Gln, Arg, Tyr, Lys, Ile, 0.753, 0.722, 4.0%, 0.730 , 0.775; Gln, Cit, Pro, Orn, Ile, 0.753, 0.682, 1.8%, 0.688, 0.679; Gln, Cit, Tyr, Leu, Phe, 0.753, 0.729, 1.7%, 0.732, 0.686; , Ile, Phe, 0.7 53, 0.704, 0.4%, 0.724, 0.679; Gln, Lys, Ile, Leu, Phe, 0.753, 0.684, 0.6%, 0.660, 0.653; Gln, Lys, Ile, Leu, Trp, 0.753, 0.685, 0.7%, 0.658 , 0.692; Gln, Tyr, Lys, Ile, Trp, 0.753, 0.719, 7.4%, 0.713, 0.753; Gln, Tyr, Orn, Leu, Trp, 0.753, 0.721, 4.6%, 0.709, 0.708; , Leu, Phe, 0.753, 0.728, 1.8%, 0.728, 0.677; Gly, Gln, Arg, Tyr, Ile, 0.753, 0.724, 5.9%, 0.730, 0.730; Gly, Gln, Cit, Tyr, Leu, 0.753, 0.717 , 2.4%, 0.708, 0.710; Gly, Gln, Pro, Tyr, Ile, 0.753, 0.721, 5.0%, 0.725, 0.736; His, Tyr, Lys, Ile, Phe, 0.753, 0.702, 4.0%, 0.690, 0.682; Thr, Tyr, Ile, Leu, Phe, 0.753, 0.724, 3.3%, 0.719, 0.675; Ala, Arg, Lys, Ile, Phe, 0.752, 0.667, 0.6%, 0.662, 0.677; Arg, Orn, Lys, Ile, Phe, 0.752, 0.667, 0.9%, 0.657, 0.661; Asn, Arg, Tyr, Leu, Phe, 0.752, 0.729, 1.5%, 0.724, 0.645; Asn, Gly, Arg, Tyr, Ile, 0.752, 0.722, 5.5% , 0.721, 0.692; Asn, His, Pro, Tyr, Ile, 0.752, 0.725, 3.9%, 0.732, 0.706; Gln, His, Arg, Ile, Leu, 0.752, 0.709, 0.6%, 0.733, 0.716; , Arg, Ile, Trp, Gln, His, Pro, Ile, Leu, 0.752, 0.709, 1.3%, 0.727, 0.730; Gln, His, Pro, Met, Ile, 0.752, 0.708, 0.9%, 0.728 , 0.714; Gln, His, Thr, Met, Ile, 0.752, 0.709, 0.4%, 0.728, 0.724; Gln, His, Tyr, Val, Leu, 0.752, 0.729, 2.2%, 0.729, 0.740; , Ile, Leu, 0.752, 0.729, 4.6%, 0.733, 0.734; Gly, Gln, Thr, Tyr, Ile, 0.752, 0.725, 6.8%, 0.729, 0.728; , 2.4%, 0.719, 0.704; Ser, Asn, Gln, Tyr, Ile, 0.752, 0.713, 5.0%, 0.720, 0.732; Ser, Asn, His, Tyr, Ile, 0.752, 0.716, 4.2%, 0.719, 0.702; Arg, Lys, Ile, Phe, Trp, 0.752, 0.671, 0.9%, 0.655, 0.669; Arg, Met, Lys, Ile, Phe, 0.752, 0.675, 0.7%, 0.662, 0.673; Ile, 0.752, 0.677, 1.8%, 0.666, 0.692; Asn, Cit, Lys, Ile, Phe, 0.752, 0.680, 1.8%, 0.661, 0.665; Asn, Cit, Tyr, Met, Ile, 0.752, 0.733, 5.1% , 0.736, 0.704; Asn, Gly, Gln, Orn, Leu, 0.752, 0.675, 0.2%, 0.657, 0.592; Asn, Gly, His, Tyr, Ile, 0.752, 0.717, 4.6%, 0.715, 0.688; , Tyr, Leu, Ph e, 0.752, 0.717, 3.1%, 0.697, 0.625; Asn, His, Met, Ile, Phe, 0.752, 0.691, 0.7%, 0.692, 0.609; Asn, His, Tyr, Lys, Ile, 0.752, 0.710, 6.4% , 0.700, 0.690; Cit, Tyr, Val, Orn, Ile, 0.752, 0.709, 5.5%, 0.713, 0.730; Gln, His, Ala, Pro, Ile, 0.752, 0.707, 1.1%, 0.728, 0.734; , Ala, Val, Ile, 0.752, 0.707, 1.1%, 0.728, 0.736; Gln, His, Met, Orn, Ile, 0.752, 0.696, 1.1%, 0.713, 0.696; Gln, His, Val, Ile, Leu, 0.752 , 0.709, 0.9%, 0.729, 0.726; Gln, Orn, Ile, Leu, Phe, 0.752, 0.687, 0.2%, 0.685, 0.637; Gln, Tyr, Val, Lys, Trp, 0.752, 0.729, 6.6%, 0.707, 0.730; Gln, Val, Lys, Ile, Phe, 0.752, 0.674, 0.7%, 0.652, 0.671; Gly, Cit, Tyr, Val, Ile, 0.752, 0.714, 5.3%, 0.704, 0.720; Cit, Ile, 0.752, 0.687, 1.1%, 0.694, 0.690; Gly, Gln, Tyr, Orn, Ile, 0.752, 0.724, 5.3%, 0.723, 0.728; Gly, His, Tyr, Ile, Phe, 0.752, 0.707, 3.7%, 0.699, 0.675; Ser, Asn, Cit, Tyr, Ile, 0.752, 0.721, 4.6%, 0.727, 0.722; Ser, Gln, His, Cit, Ile, 0.752, 0.692, 1.1%, 0.710, 0.738; , Gln, Tyr, Ile, Trp, 0.752, 0.713, 7.0%, 0.711, 0.746; Ser, Gln, Tyr, Leu, Phe, 0.752, 0.729, 1.8%, 0.728, 0.677; Thr, Arg, Lys, Ile, Phe, 0.752, 0.673, 0.9% , 0.659, 0.671; Asn, Gly, Ala, Tyr, Leu, 0.751, 0.713, 2.4%, 0.696, 0.647; Asn, Gly, Cit, Tyr, Leu, 0.751, 0.719, 3.1%, 0.704, 0.659; , Ile, Leu, Phe, 0.751, 0.712, 3.1%, 0.712, 0.673; Gln, Arg, Tyr, Ile, Phe, 0.751, 0.725, 3.9%, 0.740, 0.708; Gln, Arg, Tyr, Leu, Phe, 0.751 , 0.732, 1.5%, 0.737, 0.694; Gln, Cit, Lys, Ile, Trp, 0.751, 0.686, 0.6%, 0.674, 0.714; Gln, His, Arg, Met, Ile, 0.751, 0.710, 0.4%, 0.731, 0.704; Gln, His, Pro, Tyr, Leu, 0.751, 0.726, 2.8%, 0.733, 0.748; Gln, His, Thr, Arg, Ile, 0.751, 0.707, 0.7%, 0.731, 0.730; Met, Leu, 0.751, 0.735, 2.0%, 0.736, 0.724; Gln, Ile, Leu, Phe, Trp, 0.751, 0.695, 0.2%, 0.698, 0.639; Gln, Orn, Lys, Ile, Phe, 0.751, 0.677, Gln, Thr, Lys, Ile, Phe, 0.751, 0.678, 0.7%, 0.652, 0.661; Gly, Cit, Tyr, Met, Ile, 0.751, 0.717, 7.2%, 0.707, 0.702; , Gln, Ala, T yr, Leu, 0.751, 0.718, 2.8%, 0.708, 0.708; Gly, Gln, Cit, Lys, Ile, 0.751, 0.679, 0.7%, 0.662, 0.710; Gly, Gln, His, Ala, Ile, 0.751, 0.701, 1.1%, 0.716, 0.720; Gly, Gln, Lys, Ile, Trp, 0.751, 0.676, 0.7%, 0.644, 0.688; Gly, Gln, Thr, Lys, Ile, 0.751, 0.677, 0.7%, 0.650, 0.696; , Gln, Tyr, Orn, Leu, 0.751, 0.718, 2.8%, 0.707, 0.702; Ser, Gln, His, Arg, Ile, 0.751, 0.691, 0.6%, 0.708, 0.740; , 0.751, 0.721, 5.5%, 0.723, 0.716; Asn, Arg, Pro, Lys, Ile, 0.750, 0.671, 2.9%, 0.661, 0.669; Asn, Gln, Cit, Orn, Ile, 0.750, 0.683, 2.6%, Asn, Gln, Cit, Tyr, Leu, 0.750, 0.730, 2.0%, 0.732, 0.712; Asn, Gln, His, Tyr, Val, 0.750, 0.736, 2.2%, 0.734, 0.730; Asn, Gln, Tyr, Met, Leu, 0.750, 0.731, 3.5%, 0.729, 0.698; Asn, Thr, Val, Lys, Ile, 0.750, 0.678, 2.6%, 0.651, 0.659; Gln, His, Pro, Val, Ile, 0.750, Gln, Tyr, Lys, Leu, Trp, 0.750, 0.727, 4.2%, 0.708, 0.734; Gln, Tyr, Val, Ile, Leu, 0.750, 0.724, 3.5%, 0.728, 0.742 ; Gly, Gln, Cit , Orn, Ile, 0.750, 0.679, 1.8%, 0.678, 0.673; Gly, Gln, His, Val, Ile, 0.750, 0.703, 0.9%, 0.718, 0.720; , 5.0%, 0.728, 0.696; His, Tyr, Orn, Ile, Phe, 0.750, 0.719, 2.9%, 0.714, 0.690; Asn, Gln, Cit, Lys, Leu, 0.750, 0.678, 0.2%, 0.650, 0.621; Asn, Gln, Cit, Tyr, Ile, 0.750, 0.729, 3.5%, 0.745, 0.744; Asn, Gln, Lys, Leu, Trp, 0.750, 0.678, 0.2%, 0.650, 0.625; Asn, Gln, Thr, Lys, Ile, 0.750, 0.680, 1.5%, 0.656, 0.679; Asn, His, Met, Lys, Ile, 0.750, 0.687, 3.3%, 0.663, 0.623; Gln, His, Val, Ile, Trp, 0.750, 0.708, 1.5% , 0.723, 0.714; Gln, Met, Lys, Ile, Phe, 0.750, 0.678, 1.1%, 0.655, 0.667; Gln, Thr, Lys, Ile, Trp, 0.750, 0.682, 0.9%, 0.659, 0.706; , Met, Ile, Leu, 0.750, 0.730, 3.7%, 0.732, 0.714; Gly, Gln, His, Arg, Ile, 0.750, 0.704, 0.9%, 0.723, 0.712; Gly, Gln, Met, Lys, Ile, 0.750 Gly, Gln, Orn, Lys, Ile, 0.750, 0.678, 0.7%, 0.650, 0.696; His, Arg, Lys, Ile, Phe, 0.750, 0.678, 0.4%, 0.662, 0.661; His, Arg, Tyr, Met, Ile, 0.750, 0.729, 5.1%, 0.735, 0.710; His, Tyr, Ile, Phe, Trp, 0.750, 0.708, 4.2%, 0.700, 0.667; Ser, Arg, Lys, Ile, Trp, 0.750, Ser, Gln, Lys, Ile, Trp, 0.750, 0.662, 1.5%, 0.631, 0.692; Arg, Val, Lys, Ile, Phe, 0.750, 0.672, 0.9%, 0.659, 0.671 Asn, Cit, Met, Lys, Ile, 0.750, 0.679, 1.8%, 0.668, 0.680; Asn, Gln, Pro, Lys, Ile, 0.750, 0.677, 2.0%, 0.656, 0.667; Asn, Gln, Val, Lys , Leu, 0.750, 0.679, 0.2%, 0.647, 0.615; Asn, Gly, Thr, Lys, Ile, 0.750, 0.674, 2.6%, 0.647, 0.659; Asn, Gly, Tyr, Met, Leu, 0.750, 0.721, 4.4 %, 0.697, 0.629; Asn, His, Val, Orn, Lys, 0.750, 0.688, 1.3%, 0.669, 0.617; Asn, Thr, Met, Lys, Ile, 0.750, 0.675, 2.4%, 0.648, 0.663; Ala, Tyr, Leu, Trp, 0.750, 0.724, 4.2%, 0.713, 0.710; Gln, His, Thr, Ala, Ile, 0.750, 0.706, 1.1%, 0.726, 0.734; Gly, Gln, His, Met, Ile, 0.750, 0.702, 0.9%, 0.714, 0.708; Gly, His, Tyr, Met, Ile, 0.750, 0.723, 4.6%, 0.718 , 0.698; Ser, Gl n, Val, Lys, Ile, 0.750, 0.658, 1.7%, 0.636, 0.720; Tyr, Met, Ile, Leu, Phe, 0.750, 0.721, 4.2%, 0.710, 0.663; Asn, Cit, Arg, Tyr, Ile, Asn, Cit, Tyr, Ile, Trp, 0.749, 0.729, 6.6%, 0.738, 0.712; Asn, Gln, Ala, Lys, Leu, 0.749, 0.678, 0.6%, 0.659 , 0.643; Asn, Gln, Thr, Tyr, Leu, 0.749, 0.733, 3.7%, 0.728, 0.700; Asn, Gly, Tyr, Lys, Leu, 0.749, 0.711, 3.3%, 0.682, 0.655; Asn, His, Ile , Phe, Trp, 0.749, 0.688, 0.4%, 0.690, 0.623; Asn, His, Lys, Ile, Leu, 0.749, 0.681, 4.0%, 0.664, 0.655; Asn, His, Orn, Ile, Phe, 0.749, 0.684 , 0.9%, 0.687, 0.611; Asn, His, Thr, Ile, Phe, 0.749, 0.691, 0.7%, 0.693, 0.619; Asn, Orn, Lys, Ile, Leu, 0.749, 0.678, 1.7%, 0.654, 0.661; Asn, Pro, Tyr, Leu, Phe, 0.749, 0.719, 2.4%, 0.707, 0.639; Cit, Tyr, Met, Orn, Ile, 0.749, 0.709, 5.1%, 0.714, 0.714; Gln, Ala, Cit, Tyr, Ile, 0.749, 0.730, 3.7%, 0.747, 0.761; Gln, Ala, Tyr, Lys, Leu, 0.749, 0.715, 3.5%, 0.708, 0.728; Gln, His, Ala, Ile, Leu, 0.749, 0.705, 1.1% , 0.723, 0.728; His, Ile, Leu, Trp, 0.749, 0.707, 1.5%, 0.720, 0.702; Gln, His, Orn, Ile, Trp, 0.749, 0.699, 2.4%, 0.714, 0.704; Gln, His, Orn, Lys, Ile, 0.749, 0.693, 1.7%, 0.691, 0.710; Gln, His, Pro, Ile, Trp, 0.749, 0.707, 1.7%, 0.723, 0.710;

Thr, Ile, Leu, 0.749, 0.707, 1.1%, 0.725, 0.734; Gln, His, Tyr, Orn, Leu, 0.749, 0.719, 2.0%, 0.723, 0.748; Gln, Tyr, Lys, Ile, Leu, 0.749, Gln, Val, Lys, Ile, Leu, 0.749, 0.680, 0.7%, 0.666, 0.712; Gln, Val, Lys, Ile, Trp, 0.749, 0.678, 1.1%, 0.656, 0.712 His, Cit, Tyr, Lys, Ile, 0.749, 0.711, 3.5%, 0.711, 0.750; His, Pro, Tyr, Met, Ile, 0.749, 0.725, 4.8%, 0.725, 0.706; Ser, Asn, Gln, Orn Ser, Gln, Lys, Ile, Phe, 0.749, 0.661, 0.9%, 0.636, 0.671; Ala, Cit, Tyr, Lys, Ile, 0.749, 0.708, 4.2 %, 0.703, 0.736; Asn, Ala, Arg, Lys, Ile, 0.749, 0.670, 3.7%, 0.666, 0.686; Asn, Gln, Arg, Tyr, Ile, 0.749, 0.727, 5.3%, 0.739, 0.732; Gln, His, Pro, Tyr, 0.749, 0.735, 2.4%, 0.751, 0.738; Asn, Gln, Met, Lys, Ile, 0.749, 0.679, 2.0%, 0.658, 0.680; Asn, Gln, Tyr, Orn, Leu, Asn, Gln, Tyr, Val, Ile, 0.749, 0.727, 7.2%, 0.725, 0.714; Asn, Gly, Gln, Cit, Ile, 0.749, 0.688, 0.7%, 0.692 , 0.667; Asn, Hi s, Arg, Ile, Phe, 0.749, 0.690, 0.0%, 0.695, 0.623; Asn, His, Arg, Lys, Ile, 0.749, 0.683, 1.8%, 0.685, 0.684; Asn, Met, Lys, Ile, Leu, Asn, Thr, Orn, Lys, Ile, 0.749, 0.678, 2.4%, 0.651, 0.661; Asn, Val, Lys, Ile, Leu, 0.749, 0.674, 1.3%, 0.650 , 0.649; Cit, Arg, Lys, Ile, Phe, 0.749, 0.672, 0.9%, 0.660, 0.669; Cit, Pro, Tyr, Orn, Ile, 0.749, 0.702, 5.0%, 0.709, 0.738; , Tyr, Ile, 0.749, 0.729, 3.9%, 0.747, 0.757; Gln, Cit, Tyr, Lys, Ile, 0.749, 0.718, 3.5%, 0.725, 0.783; Gln, His, Lys, Ile, Trp, 0.749, 0.702 , 1.7%, 0.695, 0.692; Gln, His, Thr, Val, Ile, 0.749, 0.706, 1.1%, 0.724, 0.734; Gln, His, Val, Orn, Ile, 0.749, 0.697, 1.3%, 0.715, 0.714; Gln, Met, Lys, Ile, Trp, 0.749, 0.684, 0.9%, 0.660, 0.712; Gln, Pro, Tyr, Ile, Leu, 0.749, 0.724, 3.5%, 0.729, 0.746; Gln, Thr, Cit, Tyr, Ile, 0.749, 0.728, 3.1%, 0.746, 0.759; Gln, Tyr, Orn, Ile, Leu, 0.749, 0.723, 3.9%, 0.728, 0.742; Gln, Tyr, Val, Ile, Trp, 0.749, 0.732, 7.4% , 0.723, 0.726; Arg, Lys, Ile, Phe, 0.749, 0.670, 0.9%, 0.654, 0.663; Gly, Cit, Tyr, Ile, Phe, 0.749, 0.710, 5.1%, 0.709, 0.704; Gly, Gln, Cit, Pro, Ile, 0.749, 0.690, 0.7%, 0.691, 0.677; Gly, Gln, His, Lys, Ile, 0.749, 0.691, 1.3%, 0.683 , 0.702; Gly, Gln, His, Pro, Ile, 0.749, 0.702, 1.1%, 0.716, 0.716; Gly, His, Arg, Tyr, Ile, 0.749, 0.718, 3.5%, 0.723, 0.718; , Ile, Leu, 0.749, 0.727, 4.0%, 0.724, 0.698; His, Tyr, Met, Orn, Ile, 0.749, 0.726, 4.8%, 0.727, 0.708; Ser, Arg, Lys, Ile, Phe, 0.749, 0.655 , 1.1%, 0.637, 0.653; Ser, Asn, Gln, Lys, Leu, 0.749, 0.673, 0.4%, 0.642, 0.625; Arg, Tyr, Lys, Leu, Trp, 0.748, 0.714, 4.0%, 0.692, 0.684; Arg, Tyr, Val, Lys, Trp, 0.748, 0.724, 5.9%, 0.703, 0.718; Asn, Cit, Lys, Ile, Trp, 0.748, 0.679, 1.7%, 0.668, 0.680; Asn, Cit, Tyr, Leu, Phe, 0.748, 0.723, 1.5%, 0.716, 0.651; Asn, Gln, Val, Orn, Lys, 0.748, 0.675, 2.0%, 0.638, 0.613; Asn, Gly, Gln, Tyr, Val, 0.748, 0.729, 7.7% , 0.708, 0.692; sn, His, Tyr, Ile, Trp, 0.748, 0.722, 4.2%, 0.724, 0.692; Asn, His, Tyr, Leu, Phe, 0.748, 0.724, 1.7%, 0.716, 0.657; Asn, Pro, Lys, Ile, Leu, 0.748, 0.674, 2.4%, 0.649, 0.657; Asn, Tyr, Lys, Ile, Phe, 0.748, 0.707, 6.1%, 0.688, 0.663; Asn, Tyr, Lys, Leu, Trp, 0.748, 0.717, 3.5% Asn, Tyr, Met, Ile, Leu, 0.748, 0.728, 5.7%, 0.718, 0.673; Cit, Tyr, Ile, Leu, Trp, 0.748, 0.717, 4.4%, 0.710, 0.700; Cit, Tyr , Met, Lys, Ile, 0.748, 0.713, 3.9%, 0.704, 0.720; Gln, Ala, Lys, Ile, Trp, 0.748, 0.679, 0.9%, 0.659, 0.706; Gln, Arg, Tyr, Ile, Leu, 0.748 , 0.727, 2.9%, 0.736, 0.740; Gln, Cit, Arg, Orn, Ile, 0.748, 0.682, 2.9%, 0.690, 0.679; Gln, Cit, Orn, Ile, Phe, 0.748, 0.682, 1.7%, 0.689, 0.671; Gln, Cit, Orn, Ile, Trp, 0.748, 0.683, 3.1%, 0.689, 0.679; Gln, Cit, Orn, Lys, Ile, 0.748, 0.673, 1.8%, 0.663, 0.712; Ile, Trp, 0.748, 0.734, 4.0%, 0.742, 0.765; Gln, Cit, Tyr, Lys, Leu, 0.748, 0.717, 2.0%, 0.715, 0.744; Gln, His, Cit, Lys, Ile, 0.748, 0.698, 1.1%, 0.702, 0.722 Gln, His, Thr, Pro, Ile, 0.748, 0.707, 1.1%, 0.725, 0.732; Gln, His, Tyr, Val, Orn, 0.748, 0.721, 2.6%, 0.721, 0.736; Gln, Lys, Ile, Phe , Trp, 0.748, 0.677, 0.6%, 0.655, 0.659; Gln, Orn, Lys, Ile, Trp, 0.748, 0.678, 0.9%, 0.653, 0.704; Gln, Orn, Lys, Leu, Phe, 0.748, 0.671, 0.2 %, 0.641, 0.604; Gln, Pro, Tyr, Leu, Trp, 0.748, 0.725, 5.1%, 0.712, 0.712; Gln, Pro, Tyr, Lys, Leu, 0.748, 0.719, 3.7%, 0.712, 0.730; Thr, Lys, Leu, Phe, 0.748, 0.675, 0.0%, 0.647, 0.615; Gln, Tyr, Met, Ile, Trp, 0.748, 0.731, 7.5%, 0.735, 0.734; Gln, Tyr, Met, Leu, Trp, Gln, Tyr, Val, Leu, Trp, 0.748, 0.727, 4.4%, 0.710, 0.710; Gln, Tyr, Val, Lys, Ile, 0.748, 0.716, 4.4%, 0.716 , 0.755; Gly, Gln, Tyr, Met, Leu, 0.748, 0.717, 2.6%, 0.706, 0.680; Gly, Gln, Tyr, Val, Ile, 0.748, 0.721, 6.1%, 0.718, 0.722; , Val, Leu, 0.748, 0.718, 2.9%, 0.707, 0.706; Gly, Gln, Tyr, Val, Phe, 0.748, 0.724, 6.4%, 0.704, 0.677; Gly, Gln, Val, Lys, Ile, 0.748, 0.673 , 1.1%, 0.651, 0. 702; His, Tyr, Val, Met, Ile, 0.748, 0.728, 7.9%, 0.720, 0.694; Ser, Arg, Met, Lys, Ile, 0.748, 0.660, 1.7%, 0.639, 0.677; Lys, Ile, 0.748, 0.669, 3.5%, 0.652, 0.667; Ser, Thr, Tyr, Leu, Phe, 0.748, 0.721, 2.4%, 0.717, 0.655; Thr, Tyr, Lys, Ile, Phe, 0.748, 0.715, Tyr, Lys, Ile, Leu, Phe, 0.748, 0.707, 3.9%, 0.687, 0.651; Arg, Tyr, Lys, Leu, Phe, 0.747, 0.715, 1.3%, 0.704, 0.665; Asn , Ala, Cit, Tyr, Ile, 0.747, 0.728, 5.0%, 0.740, 0.716; Asn, Arg, Tyr, Ile, Leu, 0.747, 0.723, 4.4%, 0.723, 0.684; Asn, Cit, Tyr, Ile, Leu , 0.747, 0.723, 3.1%, 0.727, 0.694; Asn, Gln, His, Tyr, Orn, 0.747, 0.718, 2.4%, 0.741, 0.744; Asn, Gln, Tyr, Ile, Trp, 0.747, 0.727, 7.0%, Asn, Gly, Arg, Tyr, Leu, 0.747, 0.717, 3.1%, 0.703, 0.649; Asn, Gly, His, Tyr, Leu, 0.747, 0.715, 2.4%, 0.699, 0.647; Asn, His, Ala, Cit, Ile, 0.747, 0.702, 1.8%, 0.713, 0.669; Asn, His, Ala, Lys, Ile, 0.747, 0.680, 3.5%, 0.667, 0.671; Asn, His, Ile, Leu, Phe, 0.747, 0.690, 0.6%, 0.684, Asn, His, Met, Ile, Trp, 0.747, 0.696, 1.3%, 0.700, 0.613; Asn, His, Tyr, Orn, Ile, 0.747, 0.727, 4.6%, 0.730, 0.708; Asn, Met, Orn, Lys, Ile, 0.747, 0.678, 2.6%, 0.656, 0.667; Asn, Tyr, Leu, Phe, Trp, 0.747, 0.721, 2.6%, 0.705, 0.635; Asn, Tyr, Orn, Leu, Phe, 0.747, 0.720, 2.6%, 0.708, 0.645; Asn, Tyr, Val, Leu, Phe, 0.747, 0.722, 2.2%, 0.712, 0.643; Cit, Pro, Tyr, Val, Ile, 0.747, 0.718, 5.9%, 0.718, 0.726; , Ala, Cit, Ile, Trp, 0.747, 0.693, 0.7%, 0.705, 0.700; Gln, Ala, Tyr, Ile, Leu, 0.747, 0.723, 3.9%, 0.727, 0.738; Gln, Cit, Tyr, Orn, Leu , 0.747, 0.708, 2.0%, 0.713, 0.728; Gln, His, Cit, Tyr, Leu, 0.747, 0.726, 2.2%, 0.734, 0.746; Gln, His, Thr, Ile, Trp, 0.747, 0.705, 1.8%, 0.722, 0.722; Gln, His, Tyr, Met, Lys, 0.747, 0.734, 1.7%, 0.729, 0.765; Gln, Thr, Val, Lys, Ile, 0.747, 0.677, 1.1%, 0.660, 0.712; Val, Lys, Leu, 0.747, 0.722, 3.5%, 0.710, 0.740; Gln, Val, Met, Lys, Ile, 0.747, 0.677, 1.1%, 0.658, 0.708; Gln, Val, Orn, Lys, Ile, 0.747, 0.675, 1.1%, 0.6 58, 0.708; Gly, Gln, Ala, Lys, Ile, 0.747, 0.676, 0.9%, 0.654, 0.702; Gly, Gln, His, Ile, Trp, 0.747, 0.702, 1.5%, 0.710, 0.700; Thr, Tyr, Leu, 0.747, 0.722, 6.4%, 0.712, 0.696; Gly, His, Cit, Tyr, Ile, 0.747, 0.710, 3.1%, 0.713, 0.738; His, Arg, Met, Lys, Ile, 0.747, Ser, Asn, Arg, Tyr, Ile, 0.747, 0.716, 5.7%, 0.719, 0.712; Ser, Asn, Cit, Lys, Ile, 0.747, 0.664, 2.4%, 0.645, 0.663 Ser, Asn, Gln, Tyr, Leu, 0.747, 0.724, 2.8%, 0.719, 0.696; Ser, Gln, Tyr, Lys, Leu, 0.747, 0.719, 3.7%, 0.709, 0.732; Ser, Gly, Gln, Lys , Ile, 0.747, 0.661, 1.7%, 0.633, 0.700; Thr, Pro, Tyr, Leu, Phe, 0.747, 0.718, 3.7%, 0.713, 0.647; Thr, Tyr, Val, Leu, Phe, 0.747, 0.723, 2.8 Tyr, Ile, Leu, Phe, Trp, 0.747, 0.713, 4.2%, 0.697, 0.639; Arg, Lys, Ile, Leu, Phe, 0.747, 0.671, 0.7%, 0.656, 0.661; Arg, Pro, Tyr, Orn, Lys, 0.747, 0.686, 7.7%, 0.678, 0.765; Asn, Arg, Tyr, Orn, Lys, 0.747, 0.695, 6.1%, 0.690, 0.736; Asn, Cit, Pro, Tyr, Ile, 0.747, 0.728, 5.3%, Asn, Cit, Tyr, Val, Ile, 0.747, 0.728, 4.2%, 0.732, 0.702; Asn, Gln, Ile, Leu, Trp, 0.747, 0.701, 0.4%, 0.701, 0.655; Asn, Gln, Orn, Leu, Phe, 0.747, 0.676, 0.0%, 0.661, 0.586; Asn, Gly, His, Ile, Phe, 0.747, 0.689, 0.9%, 0.690, 0.617; Asn, Gly, His, Lys, Ile, 0.747, Asn, Gly, Met, Lys, Ile, 0.747, 0.673, 2.6%, 0.645, 0.665; Asn, His, Cit, Ile, Phe, 0.747, 0.692, 0.6%, 0.700, 0.641 Asn, His, Orn, Lys, Ile, 0.747, 0.681, 4.0%, 0.664, 0.655; Asn, His, Pro, Met, Ile, 0.747, 0.696, 1.7%, 0.700, 0.617; Asn, His, Thr, Lys Asn, His, Val, Ile, Phe, 0.747, 0.690, 0.7%, 0.689, 0.619; Asn, His, Val, Lys, Phe, 0.747, 0.687, 0.6 %, 0.662, 0.604; Asn, Tyr, Met, Lys, Leu, 0.747, 0.722, 3.3%, 0.697, 0.667; Gln, Ala, Cit, Lys, Ile, 0.747, 0.682, 1.1%, 0.677, 0.730; Ala, Tyr, Lys, Ile, 0.747, 0.717, 4.6%, 0.714, 0.757; Gln, Cit, Lys, Ile, Leu, 0.747, 0.683, 0.7%, 0.674, 0.722; Gln, Cit, Tyr, Leu, Trp, 0.747, 0.730, 2.6 %, 0.722, 0.720; Gln, Cit, Tyr, Met, Leu, 0.747, 0.729, 2.0%, 0.732, 0.724; Gln, His, Lys, Ile, Leu, 0.747, 0.696, 1.7%, 0.696, 0.738; His, Orn, Ile, Leu, 0.747, 0.697, 1.5%, 0.713, 0.702; Gln, His, Orn, Leu, Phe, 0.747, 0.686, 0.0%, 0.677, 0.621; Gln, His, Thr, Orn, Ile, 0.747, 0.697, 1.5%, 0.713, 0.712; Gln, Orn, Leu, Phe, Trp, 0.747, 0.673, 0.2%, 0.657, 0.596; Gln, Pro, Tyr, Met, Ile, 0.747, 0.732, 5.9%, 0.739 , 0.740; Gln, Pro, Tyr, Met, Leu, 0.747, 0.727, 2.8%, 0.726, 0.704; Gln, Thr, Tyr, Lys, Leu, 0.747, 0.717, 3.9%, 0.707, 0.718; , Lys, Ile, 0.747, 0.721, 4.8%, 0.719, 0.763; Gln, Tyr, Orn, Lys, Leu, 0.747, 0.716, 2.9%, 0.704, 0.734; Gln, Val, Ile, Leu, Phe, 0.747, 0.692 , 0.2%, 0.698, 0.633; Gly, Gln, Pro, Tyr, Leu, 0.747, 0.716, 3.1%, 0.703, 0.698; His, Ala, Tyr, Met, Ile, 0.747, 0.726, 5.1%, 0.725, 0.712; His, Cit, Tyr, Val, Ile, 0.747, 0.717, 2.9%, 0.718, 0.742; His, Met, Lys, Ile, Phe, 0.747, 0.671, 0.9%, 0.638, 0.588; His, Tyr, Leu, Phe, Trp, 0.747, 0.715, 2.8%, 0.692, 0.621; Ser, Cit, Tyr, Lys, Ile, 0.747, 0.704, 4.4%, 0.700, 0.734; Ser, Gln, His, Orn, Ile, 0.747, 0.687, 0.9%, 0.702, 0.726; , Gln, Lys, Leu, Phe, 0.747, 0.669, 0.2%, 0.639, 0.625; Ser, Gln, Tyr, Ile, Leu, 0.747, 0.713, 4.0%

Ser, Gln, Tyr, Val, Ile, 0.747, 0.717, 4.6%, 0.722, 0.755; Ser, Gly, Cit, Tyr, Ile, 0.747, 0.714, 4.4%, 0.715, 0.736; Thr, Cit , Tyr, Ile, Phe, 0.747, 0.719, 4.2%, 0.728, 0.700; Thr, Tyr, Lys, Leu, Phe, 0.747, 0.718, 2.4%, 0.708, 0.661; Thr, Tyr, Met, Leu, Phe, 0.747 Tyr, Met, Orn, Ile, Phe, 0.747, 0.730, 7.2%, 0.725, 0.679; Tyr, Val, Met, Ile, Phe, 0.747, 0.725, 6.4%, 0.713, Ala, Cit, Tyr, Ile, Phe, 0.746, 0.713, 5.0%, 0.725, 0.706; Asn, Arg, Tyr, Val, Ile, 0.746, 0.729, 6.6%, 0.726, 0.698; Asn, Cit, Tyr, Lys, Leu, 0.746, 0.713, 2.0%, 0.694, 0.675; Asn, Gln, His, Lys, Leu, 0.746, 0.688, 0.4%, 0.672, 0.649; Asn, Gln, Pro, Tyr, Ile, 0.746, 0.729, 4.8%, 0.735, 0.724; Asn, Gln, Val, Lys, Phe, 0.746, 0.684, 0.4%, 0.650, 0.617; Asn, Gly, Orn, Lys, Ile, 0.746, 0.677, 2.2%, 0.650, 0.663; , Gly, Tyr, Ile, Leu, 0.746, 0.713, 4.6%, 0.697, 0.659; Asn, His, Arg, Orn, Ile, 0.746, 0.688, 1.5%, 0.701, 0.655; Asn, His, Cit, Pro, Ile , 0.746, 0.705, 0 Asn, His, Tyr, Val, Ile, 0.746, 0.723, 5.0%, 0.722, 0.692; Asn, Lys, Ile, Leu, Trp, 0.746, 0.677, 1.5%, 0.652, 0.659; Asn, Orn, Lys, Ile, Phe, 0.746, 0.679, 2.6%, 0.649, 0.643; Asn, Thr, Tyr, Lys, Leu, 0.746, 0.715, 4.0%, 0.694, 0.677; Cit, Arg, Pro, Tyr, Lys, 0.746, 0.698, 4.8%, 0.685, 0.779; Cit, Pro, Tyr, Lys, Ile, 0.746, 0.702, 5.3%, 0.700, 0.746; Cit, Tyr, Lys, Ile, Phe, 0.746, 0.705, 4.8% , 0.699, 0.702; Cit, Tyr, Orn, Ile, Trp, 0.746, 0.703, 4.8%, 0.708, 0.728; Cit, Tyr, Orn, Lys, Ile, 0.746, 0.696, 4.4%, 0.694, 0.732; , Ile, Leu, Trp, 0.746, 0.695, 1.1%, 0.690, 0.663; Gln, Ala, Tyr, Leu, Phe, 0.746, 0.719, 2.0%, 0.721, 0.682; Gln, Arg, Tyr, Ile, Trp, 0.746 , 0.730, 7.2%, 0.740, 0.746; Gln, Arg, Tyr, Met, Ile, 0.746, 0.730, 5.7%, 0.741, 0.742; Gln, Cit, Arg, Tyr, Ile, 0.746, 0.730, 2.8%, 0.745, 0.757; Gln, Cit, Tyr, Val, Ile, 0.746, 0.729, 4.2%, 0.742, 0.753; Gln, Pro, Tyr, Ile, Trp, 0.746, 0.735, 8.1%, 0.739, 0.755; Lys, Ile, 0.746, 0.716 , 4.4%, 0.715, 0.751; Gln, Thr, Lys, Ile, Leu, 0.746, 0.685, 0.9%, 0.661, 0.694; Gln, Thr, Met, Lys, Ile, 0.746, 0.682, 0.9%, 0.658, 0.704; Gln, Thr, Orn, Leu, Phe, 0.746, 0.673, 0.0%, 0.655, 0.600; Gln, Thr, Orn, Lys, Ile, 0.746, 0.682, 1.1%, 0.659, 0.704; Gln, Tyr, Val, Met, Leu, 0.746, 0.728, 2.6%, 0.725, 0.712; Gly, Ala, Cit, Tyr, Ile, 0.746, 0.713, 4.0%, 0.712, 0.722; Gly, Gln, Arg, Tyr, Leu, 0.746, 0.717, 2.4% , 0.713, 0.704; Gly, Gln, His, Tyr, Val, 0.746, 0.730, 3.9%, 0.724, 0.740; Gly, Gln, Ile, Leu, Phe, 0.746, 0.685, 0.2%, 0.685, 0.633; Ser, Gln, Arg, Tyr, Ile, 0.746, 0.715, 4.2%, 0.728, 0.759; Ser, Gln, Cit, Lys, Ile, 0.746 Ser, Gln, His, Ala, Ile, 0.746, 0.691, 1.1%, 0.707, 0.732; Ser, Gln, His, Tyr, Leu, 0.746, 0.724, 2.0%, 0.728, Ser, Gln, Met, Lys, Ile, 0.746, 0.660, 1.5%, 0.635, 0.706; Ser, Gln, Thr, Lys, Ile, 0.746, 0.659, 1.8%, 0.635, 0.708; Ser, Gln, Thr, Tyr, Ile, 0.746, 0. 710, 5.7%, 0.720, 0.748; Thr, Tyr, Met, Ile, Phe, 0.746, 0.719, 5.7%, 0.718, 0.667; Ala, Cit, Tyr, Val, Ile, 0.745, 0.717, 5.5%, 0.716, 0.724 Ala, Tyr, Met, Lys, Ile, 0.745, 0.711, 5.5%, 0.693, 0.714; Asn, Gln, His, Orn, Lys, 0.745, 0.671, 2.4%, 0.665, 0.690; Asn, Gly, Tyr, Leu , Trp, 0.745, 0.716, 3.3%, 0.691, 0.637; Asn, Gly, Tyr, Val, Leu, 0.745, 0.714, 2.4%, 0.694, 0.639; Asn, His, Ala, Tyr, Ile, 0.745, 0.721, 4.4 %, 0.725, 0.694; Asn, His, Cit, Orn, Ile, 0.745, 0.687, 2.0%, 0.694, 0.647; Asn, His, Lys, Ile, Trp, 0.745, 0.681, 4.4%, 0.665, 0.655; His, Pro, Lys, Ile, 0.745, 0.679, 3.9%, 0.662, 0.655; Asn, Pro, Lys, Ile, Phe, 0.745, 0.672, 3.3%, 0.638, 0.639; Asn, Thr, Cit, Tyr, Ile, Asn, Thr, Lys, Ile, Phe, 0.745, 0.677, 2.8%, 0.645, 0.633; Asn, Thr, Lys, Ile, Trp, 0.745, 0.672, 2.2%, 0.647 Asn, Thr, Tyr, Lys, Ile, 0.745, 0.710, 8.6%, 0.695, 0.690; Asn, Tyr, Lys, Ile, Leu, 0.745, 0.706, 4.4%, 0.690, 0.679; Asn, Val, Lys , Ile, Phe, 0.745, Asn, Val, Met, Lys, Ile, 0.745, 0.674, 2.8%, 0.647, 0.663; Cit, Arg, Tyr, Ile, Phe, 0.745, 0.720, 3.7%, 0.730, 0.702 Cit, Tyr, Met, Ile, Phe, 0.745, 0.717, 4.0%, 0.722, 0.688; Cit, Tyr, Orn, Ile, Phe, 0.745, 0.702, 4.6%, 0.713, 0.702; Gln, Ala, Cit, Arg , Ile, 0.745, 0.693, 0.7%, 0.708, 0.702; Gln, Ala, Lys, Ile, Phe, 0.745, 0.671, 1.5%, 0.652, 0.677; Gln, Ala, Val, Lys, Ile, 0.745, 0.679, 1.3 %, 0.664, 0.714; Gln, Cit, Val, Orn, Ile, 0.745, 0.683, 3.1%, 0.685, 0.669; Gln, His, Thr, Lys, Ile, 0.745, 0.696, 1.3%, 0.694, 0.716; Met, Lys, Ile, Leu, 0.745, 0.685, 0.7%, 0.662, 0.700; Gln, Tyr, Met, Lys, Leu, 0.745, 0.724, 2.4%, 0.708, 0.700; Gly, Cit, Pro, Tyr, Ile, Gly, Cit, Tyr, Orn, Ile, 0.745, 0.701, 4.2%, 0.703, 0.724; Gly, Gln, His, Thr, Ile, 0.745, 0.700, 1.1%, 0.715 , 0.724; Gly, Gln, Lys, Ile, Leu, 0.745, 0.676, 0.7%, 0.649, 0.686; Gly, Gln, Lys, Leu, Phe, 0.745, 0.673, 0.2%, 0.637, 0.606; , Lys, Ile, 0.7 Ser, Asn, Gln, Leu, Phe, 0.745, 0.671, 0.0%, 0.657, 0.600; Ser, Asn, His, Ile, Phe, 0.745, 0.675, 0.6%, 0.677 Ser, Cit, Tyr, Orn, Ile, 0.745, 0.702, 4.2%, 0.710, 0.732; Ser, Gln, His, Ile, Leu, 0.745, 0.693, 0.9%, 0.710, 0.734; Ser, Gln, His Ser, Gln, His, Pro, Ile, 0.745, 0.693, 1.1%, 0.710, 0.738; Ser, Gln, His, Thr, Ile, 0.745, 0.693 , 1.1%, 0.708, 0.730; Ser, Gly, Gln, Tyr, Leu, 0.745, 0.723, 3.1%, 0.711, 0.702; Ser, Tyr, Met, Leu, Phe, 0.745, 0.727, 2.4%, 0.714, 0.643; Ala, Tyr, Lys, Ile, Phe, 0.745, 0.700, 6.4%, 0.680, 0.671; Ala, Tyr, Met, Ile, Phe, 0.745, 0.718, 6.6%, 0.709, 0.665; Arg, Orn, Lys, Ile, Trp, 0.745, 0.667, 2.8%, 0.653, 0.675; Asn, Gln, Ala, Tyr, Leu, 0.745, 0.722, 2.9%, 0.717, 0.690; Asn, Gln, Arg, Tyr, Leu, 0.745, 0.729, 3.1% , 0.725, 0.704; Asn, Gln, Cit, Pro, Ile, 0.745, 0.699, 0.9%, 0.713, 0.696; Asn, Gln, Met, Lys, Leu, 0.745, 0.678, 0.4%, 0.651, 0.627; , Tyr, Met, Ile, Asn, Gln, Val, Leu, Phe, 0.745, 0.685, 0.0%, 0.675, 0.590; Asn, Gly, Lys, Ile, Leu, 0.745, 0.674, 1.7%, 0.644 , 0.647; Asn, Gly, Pro, Tyr, Leu, 0.745, 0.712, 2.4%, 0.693, 0.639; Asn, His, Pro, Ile, Phe, 0.745, 0.687, 0.7%, 0.690, 0.621; Asn, Thr, Pro, Lys, Ile, 0.745, 0.671, 3.3%, 0.642, 0.659; Gln, Ala, Tyr, Met, Leu, 0.745, 0.722 , 2.2%, 0.719, 0.710; Gln, Arg, Tyr, Val, Lys, 0.745, 0.726, 3.1%, 0.719, 0.732; Gln, Cit, Met, Lys, Ile, 0.745, 0.683, 0.7%, 0.675, 0.728; Gln, Cit, Val, Lys, Ile, 0.745, 0.680, 0.9%, 0.675, 0.730; Gln, His, Lys, Leu, Phe, 0.745, 0.688, 0.0%, 0.671, 0.655; Gln, His, Met, Lys, Ile, 0.745, 0.697, 0.9%, 0.691, 0.700; Gln, His, Pro, Lys, Ile, 0.745, 0.695, 2.0%, 0.695, 0.714; Gln, His, Val, Lys, Ile, 0.745, 0.692, 1.7% , 0.698, 0.732; Gln, Met, Orn, Lys, Ile, 0.745, 0.680, 1.1%, 0.655, 0.700; Gln, Thr, Arg, Tyr, Ile, 0.745, 0.728, 5.7%, 0.743, 0.750; , Tyr, Ile, Tr p, 0.745, 0.727, 7.5%, 0.733, 0.746; Gln, Thr, Tyr, Met, Ile, 0.745, 0.730, 5.9%, 0.737, 0.738; Gln, Val, Orn, Leu, Phe, 0.745, 0.674, 0.2% , 0.656, 0.596; Gly, Cit, Tyr, Lys, Ile, 0.745, 0.701, 4.4%, 0.694, 0.726; Gly, Gln, Orn, Lys, Leu, 0.745, 0.667, 0.2%, 0.635, 0.629; , Tyr, Val, Lys, 0.745, 0.722, 5.3%, 0.698, 0.722; His, Arg, Lys, Ile, Trp, 0.745, 0.680, 2.0%, 0.664, 0.671; His, Arg, Tyr, Orn, Ile, 0.745 , 0.716, 3.5%, 0.730, 0.724; His, Cit, Tyr, Ile, Trp, 0.745, 0.721, 3.5%, 0.723, 0.738; Pro, Tyr, Met, Leu, Phe, 0.745, 0.715, 4.6%, 0.705, Ser, Arg, Orn, Lys, Ile, 0.745, 0.657, 1.3%, 0.641, 0.671; Ser, Asn, Gly, Tyr, Leu, 0.745, 0.717, 2.8%, 0.697, 0.629; Ser, Cit, Tyr, Ser, Gln, His, Lys, Ile, 0.745, 0.682, 0.9%, 0.672, 0.714; Ser, Gln, His, Met, Ile, 0.745, 0.689, 0.7%, 0.703, 0.712; Ser, Gln, Pro, Tyr, Ile, 0.745, 0.713, 4.8%, 0.723, 0.763; Ser, Gln, Tyr, Met, Ile, 0.745, 0.713, 5.9%, 0.718, 0.736; , Tyr, Met, Lys, Ile, 0.745, 0.708, 5.9%, 0.689, 0.714; Thr, Tyr, Orn, Leu, Phe, 0.745, 0.714, 2.9%, 0.710, 0.653; Tyr, Lys, Ile, Phe, Trp, 0.745, 0.702, 6.4% Ala, Arg, 0.683, 0.671; Tyr, Met, Ile, Phe, Trp, 0.745, 0.719, 7.9%, 0.712, 0.667; , Met, Lys, Ile, 0.744, 0.672, 2.2%, 0.662, 0.690; Arg, Tyr, Val, Met, Lys, 0.744, 0.724, 4.4%, 0.705, 0.706; , 0.701, 0.4%, 0.708, 0.653; Asn, Gln, Tyr, Val, Leu, 0.744, 0.727, 2.9%, 0.720, 0.696; Asn, Gln, Val, Ile, Leu, 0.744, 0.696, 0.2%, 0.698, Asn, Gly, His, Val, Lys, 0.744, 0.688, 1.5%, 0.671, 0.625; Asn, His, Ala, Orn, Ile, 0.744, 0.690, 2.6%, 0.690, 0.639; Asn, His, Thr, Met, Ile, 0.744, 0.697, 1.7%, 0.696, 0.615; Asn, His, Val, Lys, Ile, 0.744, 0.679, 4.6%, 0.661, 0.663; Asn, Pro, Met, Lys, Ile, 0.744, 0.673, 3.7%, 0.642, 0.665; Asn, Tyr, Met, Ile, Phe, 0.744, 0.722, 7.4%, 0.717, 0.659; Gln, Ala, Lys, Leu, Phe, 0.744, 0.675, 0.2%, 0.660, 0.623; , Ala, Tyr, M et, Ile, 0.744, 0.731, 6.1%, 0.737, 0.738; Gln, Arg, Tyr, Lys, Leu, 0.744, 0.721, 2.0%, 0.718, 0.732; Gln, Cit, Arg, Pro, Ile, 0.744, 0.700, 0.9%, 0.709, 0.696; Gln, Cit, Tyr, Ile, Leu, 0.744, 0.727, 3.1%, 0.741, 0.753; Gln, His, Ala, Leu, Trp, 0.744, 0.693, 1.5%, 0.689, 0.661; , His, Arg, Tyr, Val, 0.744, 0.730, 2.0%, 0.733, 0.744; Gln, His, Tyr, Orn, Phe, 0.744, 0.720, 0.9%, 0.745, 0.755; Gln, Orn, Lys, Ile, Leu , 0.744, 0.681, 1.1%, 0.656, 0.696; Gln, Thr, Val, Leu, Phe, 0.744, 0.680, 0.0%, 0.666, 0.617; Gln, Tyr, Val, Met, Lys, 0.744, 0.728, 4.4%, 0.708, 0.724; Gln, Val, Lys, Leu, Phe, 0.744, 0.678, 0.0%, 0.649, 0.619; Gly, Gln, Cit, Arg, Ile, 0.744, 0.688, 0.7%, 0.690, 0.677; Cit, Ile, Phe, 0.744, 0.684, 0.7%, 0.692, 0.651; Gly, Gln, Tyr, Val, Trp, 0.744, 0.728, 8.6%, 0.703, 0.700; Gly, Tyr, Met, Lys, Ile, 0.744, His, Ala, Cit, Tyr, Ile, 0.744, 0.713, 2.9%, 0.723, 0.750; His, Arg, Orn, Ile, Phe, 0.744, 0.677, 0.4%, 0.679, 0.631 ; His, Cit, Tyr Ser, Ala, Arg, Lys, Ile, 0.744, 0.657, 0.9%, 0.639, 0.677; Ser, Asn, His, Met, Ile, 0.744, 0.676 , 1.7%, 0.678, 0.643; Ser, Asn, Lys, Ile, Phe, 0.744, 0.655, 3.5%, 0.620, 0.637; Ser, Asn, Thr, Lys

Ser, Cit, Tyr, Ile, Phe, 0.744, 0.713, 5.0%, 0.723, 0.708; Ser, Gln, Ala, Tyr, Ile, 0.744, 0.712, 5.3 %, 0.720, 0.757; Ser, Gln, Lys, Leu, Trp, 0.744, 0.674, 0.2%, 0.640, 0.645; Ser, Gln, Orn, Lys, Ile, 0.744, 0.663, 1.1%, 0.640, 0.710; Tyr, Met, Ile, Phe, 0.744, 0.714, 6.8%, 0.708, 0.665; Arg, Pro, Lys, Ile, Phe, 0.743, 0.665, 1.1%, 0.650, 0.635; Asn, Gly, Val, Lys, Ile, 0.743, 0.672, 2.8%, 0.645, 0.655; Asn, Val, Orn, Lys, Ile, 0.743, 0.678, 2.2%, 0.655 , 0.665; Cit, Tyr, Ile, Phe, Trp, 0.743, 0.714, 5.3%, 0.719, 0.698; Gln, Arg, Pro, Tyr, Ile, 0.743, 0.729, 5.5%, 0.743, 0.753; , Orn, Ile, 0.743, 0.723, 5.9%, 0.740, 0.753; Gln, His, Pro, Orn, Ile, 0.743, 0.693, 1.7%, 0.710, 0.708; Gly, Tyr, Lys, Ile, Phe, 0.743, 0.701, 6.1%, 0.681, 0.667; Pro, Tyr, Lys, Ile, Phe, 0.743, 0.703, 6.1%, 0.685, 0.673; Pro, Tyr, Met, Lys, Ile, 0.743, 0.708, 6.6%, 0.688, 0.700; Ser, Cit, Tyr, Val, Ile, 0.743, 0.715, 5.3%, 0.714, 0.730; Ser, Gln, His, Val, Ile, 0.743, 0.690, 1.1%, 0.709, 0.736; Arg, Tyr, Leu, Phe, Trp, 0.743, 0.719, 2.4%, 0.710, 0.653; Asn, Arg, Orn, Lys, Leu, 0.743, 0.659, 1.1%, 0.638, 0.602; , Gln, Ala, Ile, Leu, 0.743, 0.692, 0.4%, 0.695, 0.655; Asn, Gln, Ala, Tyr, Ile, 0.743, 0.727, 6.4%, 0.733, 0.722; , 0.743, 0.683, 0.0%, 0.675, 0.592; Asn, Gln, Cit, Ile, Leu, 0.743, 0.700, 0.2%, 0.706, 0.659; Asn, Gln, Cit, Val, Ile, 0.743, 0.700, 0.2%, 0.710, 0.684; Asn, Gln, Tyr, Orn, Ile, 0.743, 0.725, 6.4%, 0.730, 0.716; Asn, Gly, Gln, Leu, Phe, 0.743, 0.677, 0.0%, 0.659, 0.580; His, Tyr, Val, 0.743, 0.722, 5.0%, 0.699, 0.667; Asn, Gly, Tyr, Met, Ile, 0.743, 0.719, 8.1%, 0.708, 0.675; Asn, His, Orn, Ile, Trp, 0.743, Asn, His, Tyr, Lys, Leu, 0.743, 0.714, 3.3%, 0.695, 0.663; Asn, Orn, Lys, Ile, Trp, 0.743, 0.675, 2.0%, 0.655, 0.667 ; Cit, Pro, Ty r, Met, Ile, 0.743, 0.724, 5.1%, 0.723, 0.710; Gln, Ala, Cit, Orn, Ile, 0.743, 0.679, 2.0%, 0.683, 0.690; Gln, Cit, Orn, Ile, Leu, 0.743, Gln, Cit, Val, Ile, Leu, 0.743, 0.699, 0.2%, 0.703, 0.665; Gln, His, Orn, Lys, Leu, 0.743, 0.683, 1.1%, 0.663, 0.651 Gln, His, Pro, Tyr, Val, 0.743, 0.727, 4.0%, 0.726, 0.744; Gln, His, Tyr, Val, Met, 0.743, 0.736, 2.2%, 0.730, 0.718; Gln, His, Tyr, Val , Phe, 0.743, 0.735, 1.8%, 0.734, 0.698; Gln, Pro, Lys, Ile, Trp, 0.743, 0.677, 1.1%, 0.653, 0.694; Gln, Thr, Cit, Lys, Ile, 0.743, 0.684, 0.7 %, 0.671, 0.724; Gln, Thr, Tyr, Lys, Ile, 0.743, 0.720, 5.3%, 0.720, 0.753; Gln, Tyr, Val, Met, Ile, 0.743, 0.731, 6.2%, 0.732, 0.726; Tyr, Leu, Phe, Trp, 0.743, 0.707, 2.6%, 0.680, 0.611; His, Arg, Met, Ile, Phe, 0.743, 0.688, 0.6%, 0.685, 0.635; Pro, Tyr, Met, Ile, Phe, Ser, Asn, His, Val, Lys, 0.743, 0.690, 1.5%, 0.672, 0.619; Ser, Asn, Tyr, Ile, Leu, 0.743, 0.713, 4.0%, 0.703 , 0.669; Tyr, Met, Leu, 0.743, 0.722, 3.5%, 0.710, 0.663; Ser, Gln, Cit, Tyr, Ile, 0.743, 0.713, 3.9%, 0.727, 0.761; Ser, Gln, Lys, Ile, Leu, 0.743, Ser, Gln, Tyr, Orn, Ile, 0.743, 0.717, 4.8%, 0.724, 0.761; Ser, His, Arg, Tyr, Ile, 0.743, 0.710, 2.9%, 0.720, 0.732 Thr, Cit, Tyr, Leu, Phe, 0.743, 0.719, 1.7%, 0.718, 0.661; Ala, Cit, Tyr, Met, Ile, 0.743, 0.726, 5.1%, 0.726, 0.714; Asn, Ala, Lys, Ile , Leu, 0.743, 0.672, 1.8%, 0.651, 0.671; Asn, Ala, Orn, Lys, Ile, 0.743, 0.677, 2.6%, 0.654, 0.686; Asn, Arg, Pro, Tyr, Ile, 0.743, 0.725, 6.1 %, 0.733, 0.704; Asn, Gln, Thr, Arg, Ile, 0.743, 0.687, 1.8%, 0.709, 0.710; Asn, Gln, Thr, Tyr, Ile, 0.743, 0.725, 6.8%, 0.733, 0.720; Gly, His, Met, Ile, 0.743, 0.692, 1.7%, 0.695, 0.609; Asn, Gly, His, Orn, Ile, 0.743, 0.688, 1.3%, 0.689, 0.627; Asn, Gly, Tyr, Lys, Ile, 0.743, 0.701, 8.1%, 0.676, 0.688; Asn, Gly, Tyr, Orn, Leu, 0.743, 0.716, 2.4%, 0.695, 0.645; Asn, His, Ala, Arg, Ile, 0.743, 0.699, 1.5%, 0.713 , 0.655; is, Val, Met, Ile, 0.743, 0.696, 1.1%, 0.696, 0.611; Asn, Met, Lys, Ile, Trp, 0.743, 0.670, 2.8%, 0.647, 0.663; Asn, Pro, Orn, Lys, Ile, Asn, Thr, Ala, Lys, Ile, 0.743, 0.670, 3.7%, 0.647, 0.673; Cit, Arg, Orn, Lys, Ile, 0.743, 0.664, 1.7%, 0.656 , 0.667; Cit, Arg, Tyr, Ile, Trp, 0.743, 0.723, 5.1%, 0.730, 0.726; Cit, Tyr, Met, Leu, Phe, 0.743, 0.721, 1.5%, 0.710, 0.657; , Ile, Trp, 0.743, 0.725, 6.1%, 0.718, 0.724; Gln, Ala, Cit, Ile, Leu, 0.743, 0.692, 0.6%, 0.701, 0.684; Gln, Ala, Met, Lys, Ile, 0.743, 0.678 , 0.9%, 0.661, 0.706; Gln, Arg, Tyr, Leu, Trp, 0.743, 0.727, 3.5%, 0.719, 0.712; Gln, Cit, Arg, Ile, Trp, 0.743, 0.699, 0.4%, 0.710, 0.692; Gln, Cit, Pro, Lys, Ile, 0.743, 0.680, 1.1%, 0.669, 0.708; Gln, Cit, Val, Ile, Phe, 0.743, 0.697, 0.4%, 0.708, 0.671; Gln, His, Ala, Lys, Ile, 0.743, 0.697, 0.9%, 0.696, 0.720; Gln, His, Tyr, Lys, Phe, 0.743, 0.730, 1.3%, 0.737, 0.775; Gln, His, Tyr, Val, Lys, 0.743, 0.727, 4.0% , 0.718, 0.750; , Orn, Lys, Leu, Trp, 0.743, 0.674, 0.2%, 0.640, 0.633; Gln, Pro, Met, Lys, Ile, 0.743, 0.676, 0.9%, 0.653, 0.690; Gln, Pro, Val, Lys, Ile , 0.743, 0.675, 1.5%, 0.655, 0.700; Gln, Thr, Arg, Tyr, Leu, 0.743, 0.728, 2.9%, 0.730, 0.730; Gln, Thr, Cit, Ile, Leu, 0.743, 0.697, 0.6%, Gln, Thr, Tyr, Leu, Trp, 0.743, 0.726, 5.5%, 0.711, 0.706; Gln, Tyr, Orn, Ile, Trp, 0.743, 0.730, 6.8%, 0.732, 0.748; Gly, Cit, Tyr, Ile, Leu, 0.743, 0.703, 4.4%, 0.697, 0.702; Gly, Gln, Orn, Leu, Phe, 0.743, 0.667, 0.0%, 0.645, 0.578; Gly, His, Arg, Ile, Phe, 0.743, 0.685, 0.6%, 0.684, 0.639; Gly, Thr, Cit, Tyr, Ile, 0.743, 0.714, 6.4%, 0.716, 0.728; His, Ala, Arg, Tyr, Ile, 0.743, 0.719, 2.9%, 0.731, 0.736 His, Arg, Orn, Lys, Ile, 0.743, 0.669, 0.7%, 0.660, 0.667; His, Arg, Pro, Tyr, Ile, 0.743, 0.718, 2.9%, 0.730, 0.734; His, Tyr, Val, Ile Pro, Tyr, Ile, Leu, Phe, 0.743, 0.710, 4.2%, 0.699, 0.647; Ser, Asn, His, Cit, Ile, 0.743, 0.686, 0.6 %, 0.692, 0.682; Ser, Gln, Cit, Orn, Ile, 0.743, 0.667, 2.6%, 0.675, 0.700; Ser, Gly, Gln, Leu, Phe, 0.743, 0.666, 0.0%, 0.645, 0.592; Thr, Tyr, Met, Lys, Ile, 0.743, 0.711, 10.5%, 0.692, 0.710; Ala, Arg, Pro, Tyr, Lys, 0.742, 0.696, 5.5%, 0.682, 0.777; Ala, Cit, Pro, Tyr, Ile, 0.742, 0.718, 4.8% Ala, Cit, Tyr, Orn, Ile, 0.742, 0.702, 4.2%, 0.709, 0.728; Arg, Met, Orn, Lys, Ile, 0.742, 0.665, 2.0%, 0.652, 0.669; Asn, Arg , Tyr, Met, Ile, 0.742, 0.726, 6.4%, 0.727, 0.694; Asn, Arg, Tyr, Val, Lys, 0.742, 0.719, 4.2%, 0.700, 0.698; Asn, Gln, Met, Leu, Phe, 0.742 , 0.687, 0.0%, 0.678, 0.619; Asn, Gln, Orn, Leu, Trp, 0.742, 0.679, 0.2%, 0.664, 0.596; Asn, Gln, Val, Orn, Leu, 0.742, 0.679, 0.2%, 0.664, Asn, Gly, Lys, Ile, Phe, 0.742, 0.674, 2.8%, 0.639, 0.643; Asn, Gly, Lys, Ile, Trp, 0.742, 0.671, 2.0%, 0.647, 0.663; Asn, Gly, Tyr, Val, Ile, 0.742, 0.721, 8.3%, 0.703, 0.673; Asn, Gly, Tyr, Val, Met, 0.742, 0.724, 9.4%, 0.697, 0.657; Asn, His, Ala, Ile, Phe, 0.742, 0.685, 0.7%, 0.689, 0.6 37; Asn, His, Pro, Orn, Ile, 0.742, 0.688, 1.5%, 0.690, 0.625; Asn, His, Thr, Arg, Ile, 0.742, 0.699, 1.3%, 0.709, 0.645; Cit, Ile, 0.742, 0.701, 0.6%, 0.708, 0.655; Asn, Orn, Lys, Leu, Phe, 0.742, 0.666, 0.6%, 0.624, 0.558; Asn, Pro, Tyr, Lys, Leu, 0.742, 0.709, 3.5%, 0.688, 0.649; Asn, Tyr, Met, Orn, Leu, 0.742, 0.719, 4.0%, 0.708, 0.661; Asn, Tyr, Val, Lys, Ile, 0.742, 0.706, 6.8%, 0.687, 0.694; , Val, Lys, Ile, Trp, 0.742, 0.671, 2.0%, 0.650, 0.661; Cit, Tyr, Lys, Ile, Leu, 0.742, 0.708, 3.9%, 0.708, 0.738; , 0.742, 0.727, 5.7%, 0.742, 0.751; Gln, Ala, Cit, Met, Ile, 0.742, 0.694, 2.2%, 0.710, 0.728; Gln, Ala, Tyr, Ile, Trp, 0.742, 0.731, 7.0%, 0.733, 0.744; Gln, Ala, Tyr, Val, Leu, 0.742, 0.718, 2.6%, 0.718, 0.738; Gln, Arg, Pro, Lys, Ile, 0.742, 0.680, 2.0%, 0.677, 0.700; Tyr, Val, Ile, 0.742, 0.728, 5.3%, 0.732, 0.740; Gln, Cit, Ile, Leu, Trp, 0.742, 0.700, 0.2%, 0.700, 0.665; Gln, Cit, Tyr, Met, Ile, 0.742, 0.727, 3.1%, 0.740, 0.751; Gln, His, Ala, Lys, Phe, 0.742, 0.680, 1.3%, 0.685, 0.716; Gln, His, Ala, Orn, Ile, 0.742, 0.692, 1.7%, 0.708, 0.706; Orn, Leu, 0.742, 0.688, 0.2%, 0.691, 0.671; Gln, His, Arg, Tyr, Leu, 0.742, 0.726, 2.0%, 0.735, 0.736; Gln, His, Tyr, Met, Phe, 0.742, 0.735, 0.9%, 0.761, 0.755; Gln, Pro, Ile, Leu, Phe, 0.742, 0.692, 0.0%, 0.694, 0.643; Gln, Val, Lys, Leu, Trp, 0.742, 0.686, 0.2%, 0.655, 0.649; , Arg, Met, Lys, Ile, 0.742, 0.669, 1.8%, 0.649, 0.671; Gly, Gln, Cit, Ile, Leu, 0.742, 0.689, 0.2%, 0.679, 0.651; Gly, Gln, Cit, Ile, Trp Gly, Thr, Tyr, Leu, Phe, 0.742, 0.712, 3.1%, 0.699, 0.617; His, Thr, Lys, Ile, Phe, 0.742, 0.677, 1.1%, Ser, Asn, Tyr, Val, Ile, 0.742, 0.719, 8.1%, 0.706, 0.682; Ser, Asn, Val, Lys, Leu, 0.742, 0.666, 0.7%, 0.629, 0.596; Ser, Gln, Tyr, Met, Leu, 0.742, 0.725, 2.6%, 0.723, 0.710; Ser, Gly, Gln, His, Ile, 0.742, 0.691, 1.1%, 0.704, 0.720; Ser, His, Cit, Tyr, Ile, 0.742, 0.713, 2.9%, 0.72 Ser, Tyr, Val, Ile, Phe, 0.742, 0.719, 5.9%, 0.708, 0.665; Thr, Tyr, Leu, Phe, Trp, 0.742, 0.722, 3.5%, 0.708, 0.639; Arg, Val, Orn, Lys, Ile, 0.742, 0.667, 2.0%, 0.653, 0.675; Asn, Ala, Tyr, Lys, Leu, 0.742, 0.709, 2.8%, 0.691, 0.661; Asn, Arg, Tyr, Ile, Phe, 0.742, Asn, Cit, Tyr, Met, Leu, 0.742, 0.726, 2.8%, 0.716, 0.671; Asn, Gln, His, Ala, Leu, 0.742, 0.694, 0.4%, 0.702, 0.643 Asn, Gln, Orn, Ile, Leu, 0.742, 0.686, 1.3%, 0.682, 0.631; Asn, Gln, Thr, Ile, Leu, 0.742, 0.693, 0.7%, 0.696, 0.661; Asn, Gly, Gln, Val , Lys, 0.742, 0.678, 0.7%, 0.642, 0.613; Asn, Gly, Tyr, Val, Lys, 0.742, 0.719, 6.8%, 0.685, 0.665; Asn, His, Arg, Met, Ile, 0.742, 0.697, 1.1 %, 0.706, 0.635; Asn, His, Cit, Val, Lys, 0.742, 0.689, 1.3%, 0.671, 0.621; Asn, His, Thr, Ile, Leu, 0.742, 0.697, 0.4%, 0.694, 0.617; His, Val, Lys, Trp, 0.742, 0.688, 1.7%, 0.671, 0.619; Asn, Pro, Tyr, Lys, Ile, 0.742, 0.706, 5.3%, 0.687, 0.696; Asn, Tyr, Met, Leu, Trp, 0.742, 0.726, 4.0%, 0 Cit, Arg, Lys, Ile, Trp, 0.742, 0.675, 1.5%, 0.658, 0.682; Cit, Tyr, Met, Ile, Trp, 0.742, 0.723, 5.3%, 0.723, 0.718; Cit, Tyr , Val, Ile, Leu, 0.742, 0.711, 4.4%, 0.712, 0.718; Gln, Ala, Orn, Lys, Ile, 0.742, 0.679, 1.1%, 0.660,

0.706; Gln, Cit, Arg, Ile, Phe, 0.742, 0.692, 0.7%, 0.704, 0.661; Gln, Cit, Met, Orn, Ile, 0.742, 0.684, 2.9%, 0.691, 0.708; Ile, Trp, 0.742, 0.700, 0.9%, 0.712, 0.700; Gln, Cit, Pro, Met, Ile, 0.742, 0.695, 1.7%, 0.706, 0.718; Gln, His, Tyr, Met, Orn, 0.742, 0.716, 2.4%, 0.740, 0.744; Gln, His, Tyr, Phe, Trp, 0.742, 0.734, 0.7%, 0.757, 0.759; Gln, Lys, Leu, Phe, Trp, 0.742, 0.675, 0.0%, 0.645, 0.613; , Thr, Cit, Orn, Ile, 0.742, 0.678, 2.4%, 0.684, 0.696; Gln, Thr, Ile, Leu, Phe, 0.742, 0.687, 0.2%, 0.688, 0.657; Gln, Thr, Orn, Ile, Leu , 0.742, 0.688, 0.9%, 0.683, 0.675; Gln, Tyr, Met, Orn, Ile, 0.742, 0.731, 5.7%, 0.737, 0.738; 0.719, 0.708; Gly, Gln, Cit, Val, Ile, 0.742, 0.691, 0.6%, 0.685, 0.661; Gly, Gln, His, Orn, Leu, 0.742, 0.685, 0.2%, 0.674, 0.647; His, Pro, Tyr, 0.742, 0.728, 5.5%, 0.746, 0.750; Gly, Gln, Orn, Ile, Leu, 0.742, 0.681, 0.9%, 0.672, 0.647; Gly, Gln, Val, Orn, Leu, 0.742, 0.674, 0.2%, 0.65 0, 0.613; Gly, Tyr, Ile, Leu, Phe, 0.742, 0.708, 4.6%, 0.689, 0.637; Gly, Tyr, Met, Ile, Phe, 0.742, 0.713, 7.4%, 0.699, 0.653; Pro, Tyr, Ile, 0.742, 0.712, 2.9%, 0.723, 0.748; Ser, Asn, Lys, Ile, Leu, 0.742, 0.658, 2.4%, 0.627, 0.641; Ser, Asn, Lys, Leu, Phe, 0.742, Ser, Gln, Pro, Lys, Ile, 0.742, 0.661, 1.7%, 0.636, 0.704; Ser, Gln, Thr, Leu, Phe, 0.742, 0.672, 0.0%, 0.653, 0.615 ; Tyr, Met, Leu, Phe, Trp, 0.742, 0.721, 2.6%, 0.703, 0.637; Arg, Orn, Lys, Ile, Leu, 0.741, 0.665, 2.2%, 0.652, 0.663; , Lys, 0.741, 0.694, 6.4%, 0.670, 0.742; Asn, Arg, Val, Orn, Lys, 0.741, 0.664, 2.2%, 0.646, 0.637; Asn, Gln, Cit, Ile, Phe, 0.741, 0.692, 0.6 %, 0.705, 0.659; Asn, Gln, Cit, Leu, Phe, 0.741, 0.683, 0.0%, 0.673, 0.590; Asn, Gln, Pro, Orn, Ile, 0.741, 0.684, 2.0%, 0.695, 0.679; Gln, Thr, Orn, Leu, 0.741, 0.677, 0.2%, 0.663, 0.598; Asn, Gly, His, Ala, Ile, 0.741, 0.694, 2.2%, 0.696, 0.643; Asn, Gly, Lys, Leu, Phe, 0.741, 0.665, 0.4%, 0 Asn, His, Arg, Ile, Trp, 0.741, 0.698, 1.3%, 0.706, 0.643; Asn, His, Arg, Tyr, Lys, 0.741, 0.714, 3.5%, 0.712, 0.748; Asn, His , Arg, Val, Ile, 0.741, 0.700, 1.1%, 0.708, 0.641; Asn, His, Met, Ile, Leu, 0.741, 0.696, 0.7%, 0.694, 0.611; Asn, His, Pro, Val, Ile, 0.741 , 0.698, 0.9%, 0.698, 0.635; Asn, His, Thr, Tyr, Ile, 0.741, 0.726, 5.9%, 0.736, 0.702; Asn, His, Val, Ile, Trp, 0.741, 0.698, 1.1%, 0.697, Asn, Tyr, Val, Ile, Leu, 0.741, 0.718, 3.7%, 0.711, 0.669; Asn, Val, Lys, Leu, Phe, 0.741, 0.669, 0.4%, 0.630, 0.568; Cit, Tyr, Val, Ile, Phe, 0.741, 0.718, 4.8%, 0.715, 0.692; Gln, Ala, Cit, Pro, Ile, 0.741, 0.694, 0.9%, 0.704, 0.700; Gln, Arg, Lys, Leu, Phe, 0.741, 0.674, Gln, Arg, Orn, Leu, Phe, 0.741, 0.669, 0.2%, 0.658, 0.592; Gln, Cit, Arg, Ile, Leu, 0.741, 0.699, 0.2%, 0.702, 0.669; , Cit, Pro, Ile, Leu, 0.741, 0.699, 0.6%, 0.699, 0.667; Gln, Cit, Tyr, Val, Leu, 0.741, 0.724, 2.2%, 0.729, 0.742; Gln, His, Ala, Tyr, Lys , 0.741, 0.722, 4.4% , 0.725, 0.769; Gln, His, Arg, Tyr, Phe, 0.741, 0.737, 0.7%, 0.766, 0.763; Gln, His, Pro, Tyr, Lys, 0.741, 0.719, 6.1%, 0.723, 0.771; , Orn, Lys, Ile, 0.741, 0.677, 1.3%, 0.655, 0.688; Gln, Thr, Ala, Lys, Ile, 0.741, 0.679, 1.1%, 0.661, 0.706; Gln, Thr, Arg, Orn, Ile, 0.741 , 0.683, 1.7%, 0.703, 0.710; Gln, Thr, Leu, Phe, Trp, 0.741, 0.679, 0.0%, 0.665, 0.609; Gln, Tyr, Val, Lys, Phe, 0.741, 0.728, 4.6%, 0.710, 0.708; Gln, Tyr, Val, Orn, Leu, 0.741, 0.717, 2.8%, 0.714, 0.736; Gly, Arg, Tyr, Val, Lys, 0.741, 0.714, 3.5%, 0.696, 0.700; Leu, Phe, 0.741, 0.674, 0.0%, 0.657, 0.580; Gly, Gln, Arg, Tyr, Val, 0.741, 0.727, 4.2%, 0.712, 0.708; Gly, Gln, Cit, Met, Ile, 0.741, 0.690, 1.3%, 0.692, 0.700; Gly, Gln, Met, Orn, Leu, 0.741, 0.671, 0.2%, 0.651, 0.617; Gly, His, Lys, Ile, Phe, 0.741, 0.672, 1.3%, 0.643, 0.617; , Tyr, Met, Ile, Leu, 0.741, 0.714, 6.4%, 0.694, 0.665; His, Thr, Arg, Ile, Phe, 0.741, 0.684, 0.2%, 0.682, 0.641; , 0.741, 0.719, 1 Ser, Gln, Cit, Tyr, Leu, 0.741, 0.722, 2.0%, 0.727, 0.740; Ser, Gln, His, Orn, Leu, 0.741, 0.684, 0.4%, 0.677, 0.651; Ser, Gln, Tyr, Val, Leu, 0.741, 0.721, 2.8%, 0.718, 0.736; Ser, Tyr, Ile, Leu, Phe, 0.741, 0.714, 4.0%, 0.704, 0.653; Thr, Arg, Lys, Ile, Leu, 0.741, 0.677, 1.8%, 0.660, 0.680; Thr, Arg, Tyr, Leu, Phe, 0.741, 0.723, 1.7%, 0.725, 0.657; Thr, Cit, Tyr, Met, Ile, 0.741, 0.726, 5.5% , 0.726, 0.708; Thr, Cit, Tyr, Orn, Ile, 0.741, 0.702, 5.5%, 0.716, 0.726; Tyr, Met, Ile, Leu, Trp, 0.741, 0.721, 6.4%, 0.708, 0.680; , Lys, Leu, Phe, 0.741, 0.719, 3.1%, 0.698, 0.645; Tyr, Orn, Lys, Ile, Phe, 0.741, 0.715, 4.4%, 0.692, 0.690; Tyr, Val, Ile, Leu, Phe, 0.741 Ala, Tyr, Ile, Leu, Phe, 0.740, 0.707, 4.0%, 0.699, 0.657; Arg, Lys, Ile, Leu, Trp, 0.740, 0.676, 1.7%, 0.654, Arg, Tyr, Met, Leu, Phe, 0.740, 0.721, 1.5%, 0.718, 0.663; Asn, Ala, Arg, Tyr, Ile, 0.740, 0.722, 6.2%, 0.728, 0.702; Asn, Ala, Tyr, Ile, Leu, 0.740, 0.717 , 3.7%, 0.709, 0.671; Asn, Ala, Tyr, Lys, Ile, 0.740, 0.705, 7.9%, 0.682, 0.686; Asn, Ala, Tyr, Val, Ile, 0.740, 0.728, 8.3%, 0.717, 0.684; Asn, Cit, Ile, Leu, Phe, 0.740, 0.686, 0.6%, 0.681, 0.613; Asn, Gln, His, Val, Lys, 0.740, 0.693, 1.1%, 0.676, 0.655; Asn, Gln, Met, Ile, Leu, 0.740, 0.697, 0.9%, 0.702, 0.655; Asn, Gln, Met, Orn, Leu, 0.740, 0.681, 0.2%, 0.670, 0.607; Asn, Gln, Pro, Ile, Phe, 0.740, 0.687, 1.3% , 0.701, 0.673; Asn, Gln, Thr, Val, Lys, 0.740, 0.680, 0.9%, 0.650, 0.631; Asn, Gly, Gln, Ile, Leu, 0.740, 0.688, 0.7%, 0.681, 0.627; , His, Arg, Ile, 0.740, 0.693, 1.3%, 0.702, 0.633; Asn, Gly, Ile, Leu, Phe, 0.740, 0.675, 0.6%, 0.664, 0.580; Asn, Gly, Pro, Lys, Ile, 0.740 Asn, His, Arg, Pro, Ile, 0.740, 0.697, 1.5%, 0.708, 0.647; Asn, His, Cit, Ile, Leu, 0.740, 0.702, 0.4%, 0.706, Asn, His, Thr, Val, Ile, 0.740, 0.699, 0.9%, 0.699, 0.623; Asn, Met, Lys, Leu, Phe, 0.740, 0.669, 0.4%, 0.635, 0.572; Asn, Pro, Tyr, Ile, Leu, 0.740, 0. 720, 4.8%, 0.714, 0.665; Asn, Pro, Tyr, Met, Leu, 0.740, 0.722, 2.9%, 0.712, 0.661; Asn, Pro, Val, Lys, Ile, 0.740, 0.670, 3.1%, 0.640, 0.669 Asn, Thr, Pro, Tyr, Leu, 0.740, 0.722, 3.7%, 0.715, 0.663; Asn, Tyr, Lys, Ile, Trp, 0.740, 0.703, 7.7%, 0.678, 0.688; Asn, Tyr, Orn, Lys , Ile, 0.740, 0.715, 5.9%, 0.694, 0.708; Asn, Tyr, Val, Lys, Leu, 0.740, 0.713, 3.3%, 0.689, 0.661; Asn, Tyr, Val, Met, Leu, 0.740, 0.725, 4.2 %, 0.713, 0.663; Cit, Pro, Tyr, Ile, Phe, 0.740, 0.711, 4.8%, 0.721, 0.700; Cit, Tyr, Val, Lys, Ile, 0.740, 0.708, 4.6%, 0.703, 0.736; Ala, Lys, Ile, Leu, 0.740, 0.680, 0.9%, 0.664, 0.702; Gln, Arg, Tyr, Met, Leu, 0.740, 0.726, 2.4%, 0.726, 0.708; Gln, Cit, Met, Ile, Trp, Gln, Cit, Pro, Ile, Phe, 0.740, 0.693, 0.7%, 0.702, 0.655; Gln, His, Ala, Orn, Leu, 0.740, 0.680, 1.3%, 0.679 , 0.661; Gln, His, Thr, Tyr, Leu, 0.740, 0.726, 2.6%, 0.734, 0.734; Gln, His, Tyr, Lys, Trp, 0.740, 0.726, 2.8%, 0.727, 0.777; , Ile, Phe, 0.740, Gln, Pro, Orn, Ile, Leu, 0.740, 0.687, 1.5%, 0.686, 0.669; Gln, Thr, Lys, Leu, Trp, 0.740, 0.684, 0.2%, 0.655, 0.649 Gln, Val, Orn, Ile, Leu, 0.740, 0.685, 0.7%, 0.681, 0.659; Gly, Arg, Orn, Lys, Ile, 0.740, 0.664, 1.3%, 0.646, 0.663; Gly, Gln, Ala, Tyr , Val, 0.740, 0.725, 7.7%, 0.707, 0.710; Gly, Gln, His, Leu, Phe, 0.740, 0.691, 0.0%, 0.682, 0.619; Gly, Gln, His, Tyr, Lys, 0.740, 0.724, 4.0 %, 0.724, 0.769; Gly, Gln, Lys, Leu, Trp, 0.740, 0.675, 0.2%, 0.637, 0.619; Cit, Tyr, Ile, Leu, 0.740, 0.714, 3.1%, 0.721, 0.736; His, Tyr, Met, Leu, Phe, 0.740, 0.719, 2.6%, 0.707, 0.641; Ser, Asn, Gln, Thr, Leu, Ser, Asn, Gln, Val, Lys, 0.740, 0.677, 0.6%, 0.644, 0.631; Ser, Asn, His, Ala, Ile, 0.740, 0.677, 2.9%, 0.678 Ser, Gln, Ala, Tyr, Leu, 0.740, 0.714, 2.6%, 0.714, 0.732; Ser, Gln, Orn, Leu, Phe, 0.740, 0.665, 0.0%, 0.645, 0.598; Ser, Thr, Arg , Lys, Ile, 0.7 Ser, Tyr, Lys, Ile, Phe, 0.740, 0.705, 6.1%, 0.686, 0.671; Thr, Arg, Orn, Lys, Ile, 0.740, 0.666, 2.4%, 0.654 Tyr, Lys, Leu, Phe, Trp, 0.740, 0.709, 2.6%, 0.679, 0.619; Tyr, Met, Orn, Lys, Ile, 0.740, 0.719, 6.1%, 0.698, 0.712; Tyr, Orn, Leu , Phe, Trp, 0.740, 0.713, 2.6%, 0.692, 0.625
［１０．アミノ酸を含む６変数の式］
Gln, His, Tyr, Ile, Phe, Trp, 0.785, 0.746, 4.2%, 0.767, 0.746; Asn, Gly, Gln, Tyr, Leu, Phe, 0.780, 0.733, 2.9%, 0.722, 0.657; Gln, His, Arg, Tyr, Ile, Phe, 0.780, 0.738, 2.0%, 0.765, 0.751; Asn, Gln, His, Cit, Orn, Ile, 0.780, 0.699, 1.8%, 0.719, 0.708; Gln, His, Tyr, Met, Ile, Phe, 0.780, 0.741, 2.0%, 0.762, 0.736; Asn, Arg, Tyr, Lys, Ile, Phe, 0.779, 0.724, 4.0%, 0.720, 0.708; Arg, Tyr, Met, Lys, Ile, Phe, 0.778, 0.724, 3.9%, 0.721, 0.708; Asn, Arg, Tyr, Met, Lys, Ile, 0.778, 0.727, 5.9%, 0.726, 0.724; Asn, Gly, Arg, Tyr, Lys, Ile, 0.778, 0.715, 4.6%, 0.704, 0.704; Gln, His, Tyr, Ile, Leu, Phe, 0.778, 0.738, 2.2%, 0.754, 0.726; Gln, His, Tyr, Orn, Ile, Phe, 0.778, 0.733, 2.2%, 0.755, 0.732; His, Arg, Tyr, Lys, Ile, Phe, 0.778, 0.721, 2.9%, 0.725, 0.722; Arg, Tyr, Lys, Ile, Phe, Trp, 0.777, 0.723, 4.0%, 0.717, 0.712; Asn, Gln, His, Tyr, Ile, Trp, 0.777, 0.744, 5.5%, 0.763, 0.765; Gly, Arg, Tyr, Lys, Ile, Phe, 0.777, 0.719, 2.2%, 0.714, 0.706; Arg, Tyr, Lys, Ile, Leu, Phe, 0.777, 0.723, 3.1%, 0.721, 0.706; Asn, Gln, His, Tyr, Ile, Phe, 0.777, 0.737, 1.8%, 0.760, 0.726; Gln, His, Ala, Tyr, Ile, Phe, 0.777, 0.736, 2.2%, 0.757, 0.740; Gln, His, Tyr, Val, Ile, Phe, 0.777, 0.736, 2.2%, 0.755, 0.732; Gln, Tyr, Lys, Ile, Leu, Phe, 0.777, 0.730, 4.4%, 0.728, 0.722; Ser, Gln, His, Tyr, Ile, Phe, 0.777, 0.733, 2.4%, 0.755, 0.742; Arg, Tyr, Orn, Lys, Ile, Phe, 0.776, 0.721, 2.9%, 0.723, 0.726; Gly, Gln, His, Tyr, Ile, Phe, 0.776, 0.733, 2.8%, 0.750, 0.736; Gly, Gln, His, Tyr, Met, Ile, 0.776, 0.739, 5.5%, 0.753, 0.744; Ser, Gln, His, Tyr, Ile, Trp, 0.776, 0.728, 4.4%, 0.741, 0.755; Asn, Gly, Gln, His, Tyr, Ile, 0.775, 0.732, 3.3%, 0.750, 0.748; Gln, Tyr, Ile, Leu, Phe, Trp, 0.775, 0.737, 4.4%, 0.739, 0.704; Gly, Gln, His, Tyr, Ile, Trp, 0.775, 0.736, 6.2%, 0.744, 0.750; Gly, Gln, Tyr, Ile, Leu, Phe, 0.775, 0.727, 3.3%, 0.723, 0.706; Arg, Tyr, Val, Lys, Ile, Phe, 0.775, 0.722, 2.8%, 0.721, 0.718; Asn, Gln, His, Cit, Ile, Phe, 0.775, 0.711, 0.2%, 0.739, 0.679; Asn, Gln, His, Lys, Ile, Phe, 0.775, 0.702, 0.7%, 0.700, 0.641; Gln, His, Cit, Orn, Ile, Phe, 0.775, 0.695, 0.6%, 0.710, 0.684; Gln, His, Pro, Tyr, Ile, Phe, 0.775, 0.735, 2.2%, 0.756, 0.734; Gln, His, Thr, Tyr, Ile, Phe, 0.775, 0.741, 2.8%, 0.761, 0.734; Gln, His, Tyr, Lys, Ile, Phe, 0.775, 0.730, 4.2%, 0.740, 0.732; Ser, Arg, Tyr, Lys, Ile, Phe, 0.775, 0.717, 2.6%, 0.719, 0.722; Ser, Asn, Gln, His, Tyr, Ile, 0.775, 0.734, 3.5%, 0.754, 0.763; Arg, Tyr, Met, Lys, Ile, Trp, 0.774, 0.725, 5.7%, 0.720, 0.736; Asn, Gln, His, Tyr, Met, Ile, 0.774, 0.743, 3.1%, 0.765, 0.751; Gln, His, Tyr, Leu, Phe, Trp, 0.774, 0.743, 2.0%, 0.745, 0.704; Asn, Arg, Tyr, Lys, Ile, Trp, 0.773, 0.718, 6.6%, 0.713, 0.726; Asn, Cit, Arg, Tyr, Lys, Ile, 0.773, 0.721, 5.1%, 0.721, 0.748; Gln, His, Cit, Tyr, Ile, Phe, 0.773, 0.736, 2.0%, 0.760, 0.750; Ser, Asn, Arg, Tyr, Lys, Ile, 0.773, 0.710, 4.4%, 0.708, 0.724; Asn, Gln, Arg, Tyr, Lys, Ile, 0.773, 0.730, 5.7%, 0.731, 0.759; Asn, Gln, Tyr, Ile, Leu, Phe, 0.773, 0.734, 3.1%, 0.736, 0.686; Asn, His, Arg, Tyr, Lys, Ile, 0.773, 0.721, 4.8%, 0.728, 0.746; Gly, Arg, Tyr, Met, Lys, Ile, 0.773, 0.720, 4.2%, 0.708, 0.716; Gln, His, Arg, Tyr, Orn, Ile, 0.772, 0.729, 2.2%, 0.760, 0.791; Gln, Pro, Tyr, Lys, Ile, Phe, 0.772, 0.725, 5.5%, 0.720, 0.726; Gln, Tyr, Met, Lys, Ile, Phe, 0.772, 0.727, 6.1%, 0.723, 0.722; His, Tyr, Met, Lys, Ile, Phe, 0.772, 0.726, 3.7%, 0.715, 0.688; Asn, Gln, His, Tyr, Orn, Ile, 0.771, 0.734, 3.9%, 0.756, 0.753; Asn, Gln, His, Val, Ile, Phe, 0.771, 0.708, 0.0%, 0.743, 0.677; Gly, Gln, Arg, Tyr, Lys, Ile, 0.771, 0.720, 4.4%, 0.715, 0.755; Gly, Gln, Tyr, Leu, Phe, Trp, 0.771, 0.730, 2.9%, 0.719, 0.675; Ser, Gln, Tyr, Lys, Ile, Phe, 0.771, 0.719, 5.5%, 0.713, 0.736; Thr, Arg, Tyr, Lys, Ile, Phe, 0.771, 0.722, 4.6%, 0.725, 0.710; Asn, Gln, His, Ala, Cit, Ile, 0.771, 0.715, 0.7%, 0.743, 0.720; Asn, Gln, His, Cit, Arg, Ile, 0.771, 0.717, 0.9%, 0.743, 0.726; Asn, Gln, His, Thr, Tyr, Ile, 0.771, 0.741, 4.0%, 0.762, 0.755; Asn, Gln, Tyr, Lys, Ile, Phe, 0.771, 0.726, 7.4%, 0.715, 0.700; Gln, Arg, Tyr, Ile, Leu, Phe, 0.771, 0.734, 2.8%, 0.744, 0.704; Gln, His, Cit, Tyr, Ile, Trp, 0.771, 0.744, 4.0%, 0.765, 0.787; Gln, His, Cit, Tyr, Orn, Ile, 0.771, 0.718, 2.4%, 0.748, 0.795; Gly, Gln, His, Tyr, Leu, Phe, 0.771, 0.726, 2.9%, 0.722, 0.692; Ala, Arg, Tyr, Lys, Ile, Phe, 0.770, 0.716, 2.6%, 0.722, 0.730; Asn, Gln, His, Arg, Ile, Phe, 0.770, 0.709, 0.0%, 0.740, 0.675; Asn, Gln, His, Cit, Pro, Ile, 0.770, 0.717, 1.1%, 0.744, 0.722; Asn, Gln, His, Pro, Tyr, Ile, 0.770, 0.738, 3.9%, 0.760, 0.759; Asn, Gln, His, Tyr, Ile, Leu, 0.770, 0.735, 3.9%, 0.752, 0.755; Cit, Arg, Tyr, Lys, Ile, Phe, 0.770, 0.718, 2.8%, 0.720, 0.722; Gln, Arg, Tyr, Lys, Ile, Phe, 0.770, 0.729, 4.0%, 0.733, 0.736; Gln, Cit, Tyr, Ile, Leu, Phe, 0.770, 0.731, 2.4%, 0.746, 0.706; Gln, His, Ala, Tyr, Ile, Trp, 0.770, 0.741, 5.1%, 0.755, 0.761; Gln, His, Cit, Arg, Ile, Phe, 0.770, 0.712, 0.2%, 0.733, 0.692; Gln, His, Cit, Pro, Orn, Ile, 0.770, 0.696, 1.5%, 0.709, 0.714; Ser, Gln, Tyr, Met, Ile, Phe, 0.770, 0.721, 5.9%, 0.733, 0.716; Asn, Arg, Tyr, Orn, Lys, Ile, 0.770, 0.716, 5.3%, 0.714, 0.730; Asn, Arg, Tyr, Val, Lys, Ile, 0.770, 0.715, 5.3%, 0.711, 0.724; Asn, Gln, Arg, Orn, Lys, Ile, 0.770, 0.677, 2.8%, 0.673, 0.694; Asn, Gln, His, Arg, Tyr, Ile, 0.770, 0.739, 3.3%, 0.763, 0.771; Asn, Gln, His, Cit, Ile, Trp, 0.770, 0.718, 1.1%, 0.741, 0.718; Asn, Gln, His, Met, Ile, Phe, 0.770, 0.712, 0.2%, 0.743, 0.684; Gln, His, Arg, Tyr, Ile, Trp, 0.770, 0.743, 4.2%, 0.764, 0.765; Gln, His, Cit, Ile, Leu, Phe, 0.770, 0.712, 0.0%, 0.733, 0.690; Gln, His, Thr, Tyr, Orn, Ile, 0.770, 0.729, 3.9%, 0.752, 0.765; Gln, His, Tyr, Ile, Leu, Trp, 0.770, 0.738, 5.0%, 0.747, 0.742; Gln, His, Tyr, Met, Ile, Trp, 0.770, 0.746, 6.1%, 0.762, 0.755; Gln, His, Tyr, Orn, Ile, Trp, 0.770, 0.735, 5.3%, 0.750, 0.751; Gln, His, Tyr, Orn, Leu, Phe, 0.770, 0.725, 1.3%, 0.731, 0.696; Gln, Pro, Tyr, Ile, Leu, Phe, 0.770, 0.731, 3.3%, 0.736, 0.706; Gln, Tyr, Val, Lys, Ile, Phe, 0.770, 0.724, 5.5%, 0.719, 0.726; Gly, Gln, His, Cit, Ile, Phe, 0.770, 0.705, 0.2%, 0.723, 0.677; Gly, Gln, Tyr, Met, Ile, Phe, 0.770, 0.722, 5.3%, 0.725, 0.710; Ser, Gln, Tyr, Ile, Leu, Phe, 0.770, 0.725, 3.3%, 0.732, 0.708; Asn, Ala, Arg, Tyr, Lys, Ile, 0.769, 0.717, 5.3%, 0.714, 0.730; Asn, Arg, Tyr, Lys, Ile, Leu, 0.769, 0.717, 4.4%, 0.716, 0.728; Asn, Gln, His, Ala, Tyr, Ile, 0.769, 0.738, 3.9%, 0.759, 0.765; Asn, Gln, His, Ile, Leu, Phe, 0.769, 0.710, 0.0%, 0.737, 0.671; Asn, Gln, His, Ile, Phe, Trp, 0.769, 0.710, 0.0%, 0.738, 0.673; Asn, Gln, His, Tyr, Val, Ile, 0.769, 0.737, 3.9%, 0.759, 0.763; Gln, His, Ala, Arg, Tyr, Ile, 0.769, 0.735, 2.2%, 0.760, 0.787; Gln, His, Cit, Orn, Ile, Leu, 0.769, 0.697, 0.9%, 0.717, 0.730; Gln, His, Cit, Val, Orn, Ile, 0.769, 0.696, 0.9%, 0.715, 0.728; Gln, Tyr, Lys, Leu, Phe, Trp, 0.769, 0.733, 2.6%, 0.722, 0.696; Gly, Gln, His, Tyr, Val, Trp, 0.769, 0.740, 5.1%, 0.728, 0.732; Gly, Gln, Tyr, Met, Leu, Phe, 0.769, 0.726, 2.6%, 0.715, 0.671; Asn, Arg, Pro, Tyr, Lys, Ile, 0.768, 0.715, 5.1%, 0.712, 0.722; Asn, Gln, His, Orn, Ile, Phe, 0.768, 0.692, 0.7%, 0.718, 0.659; Asn, Gly, Cit, Tyr, Ile, Leu, 0.768, 0.721, 4.6%, 0.717, 0.696; Asn, Gly, Gln, Cit, Tyr, Ile, 0.768, 0.728, 5.9%, 0.731, 0.720; Asn, Gly, Gln, Tyr, Lys, Leu, 0.768, 0.727, 4.0%, 0.707, 0.692; Asn, Thr, Arg, Tyr, Lys, Ile, 0.768, 0.721, 5.3%, 0.718, 0.730; Gln, His, Cit, Ile, Phe, Trp, 0.768, 0.712, 0.2%, 0.732, 0.682; Gln, His, Cit, Pro, Ile, Phe, 0.768, 0.710, 0.2%, 0.732, 0.680; Gln, Tyr, Orn, Ile, Leu, Phe, 0.768, 0.727, 3.3%, 0.733, 0.696; Gln, Tyr, Val, Ile, Phe, Trp, 0.768, 0.735, 7.5%, 0.737, 0.706; Ser, Gln, His, Tyr, Met, Ile, 0.768, 0.734, 5.3%, 0.750, 0.759; Asn, Cit, Tyr, Lys, Ile, Trp, 0.768, 0.717, 7.0%, 0.711, 0.722; Asn, Cit, Tyr, Met, Lys, Ile, 0.768, 0.720, 7.4%, 0.712, 0.724; Asn, Gln, Arg, Lys, Ile, Phe, 0.768, 0.682, 1.8%, 0.675, 0.679; Asn, Gln, His, Cit, Val, Ile, 0.768, 0.715, 0.9%, 0.743, 0.724; Asn, Gln, His, Val, Lys, Ile, 0.768, 0.694, 3.3%, 0.696, 0.728; Asn, Gln, Tyr, Leu, Phe, Trp, 0.768, 0.738, 2.4%, 0.733, 0.671; Asn, Gly, Arg, Tyr, Lys, Leu, 0.768, 0.721, 2.8%, 0.704, 0.680; Asn, Gly, Gln, His, Tyr, Leu, 0.768, 0.730, 2.6%, 0.727, 0.706; Asn, His, Arg, Lys, Ile, Phe, 0.768, 0.688, 0.7%, 0.683, 0.665; Gln, His, Arg, Lys, Ile, Phe, 0.768, 0.701, 0.2%, 0.710, 0.710; Gln, His, Cit, Pro, Val, Ile, 0.768, 0.712, 1.1%, 0.739, 0.742; Gln, His, Cit, Val, Ile, Phe, 0.768, 0.709, 0.0%, 0.732, 0.694; Gly, Gln, His, Cit, Orn, Ile, 0.768, 0.693, 0.7%, 0.704, 0.724; Gly, Gln, Tyr, Met, Lys, Ile, 0.768, 0.719, 5.1%, 0.700, 0.722; Gly, Gln, Tyr, Val, Leu, Phe, 0.768, 0.724, 2.4%, 0.718, 0.690; His, Arg, Tyr, Met, Lys, Ile, 0.768, 0.727, 7.0%, 0.726, 0.738; Ser, Gln, His, Cit, Orn, Ile, 0.768, 0.692, 0.9%, 0.706, 0.734; Ser, Gln, Tyr, Ile, Phe, Trp, 0.768, 0.720, 6.8%, 0.729, 0.724; Asn, Gln, His, Ala, Ile, Trp, 0.767, 0.710, 1.7%, 0.730, 0.696; Asn, Gln, His, Pro, Val, Ile, 0.767, 0.713, 1.7%, 0.741, 0.726; Asn, Gln, His, Thr, Ile, Phe, 0.767, 0.707, 0.2%, 0.735, 0.682; Asn, Gln, Tyr, Lys, Leu, Phe, 0.767, 0.731, 2.2%, 0.719, 0.671; Asn, Gln, Tyr, Met, Leu, Phe, 0.767, 0.738, 2.2%, 0.737, 0.677; Asn, His, Tyr, Met, Lys, Ile, 0.767, 0.727, 6.8%, 0.718, 0.702; Gln, His, Ala, Tyr, Orn, Ile, 0.767, 0.727, 2.4%, 0.751, 0.773; Gln, His, Arg, Pro, Tyr, Ile, 0.767, 0.734, 2.4%, 0.759, 0.785; Gln, His, Cit, Arg, Orn, Ile, 0.767, 0.698, 0.9%, 0.715, 0.722; Gln, His, Cit, Met, Orn, Ile, 0.767, 0.697, 0.9%, 0.712, 0.722; Gln, His, Tyr, Met, Orn, Ile, 0.767, 0.735, 6.2%, 0.755, 0.751; Gln, Tyr, Met, Ile, Leu, Phe, 0.767, 0.729, 2.9%, 0.733, 0.688; Gln, Tyr, Val, Ile, Leu, Phe, 0.767, 0.730, 2.9%, 0.740, 0.698; Gly, Gln, Pro, Tyr, Leu, Phe, 0.767, 0.724, 2.6%, 0.716, 0.679; Ser, Asn, Gln, Tyr, Leu, Phe, 0.767, 0.737, 2.2%, 0.736, 0.675; Ser, Gln, Arg, Tyr, Lys, Ile, 0.767, 0.715, 3.3%, 0.720, 0.783; Asn, Cit, Tyr, Ile, Leu, Phe, 0.766, 0.726, 2.0%, 0.724, 0.673; Asn, Gln, Cit, Tyr, Leu, Phe, 0.766, 0.737, 1.7%, 0.737, 0.675; Asn, Gln, His, Pro, Ile, Phe, 0.766, 0.708, 0.4%, 0.738, 0.669; Asn, Gly, Gln, His, Cit, Ile, 0.766, 0.709, 1.5%, 0.728, 0.700; Asn, Gly, Gln, His, Ile, Phe, 0.766, 0.703, 0.0%, 0.732, 0.669; Asn, Gly, Gln, Lys, Ile, Leu, 0.766, 0.681, 2.0%, 0.654, 0.659; A

sn, Gly, His, Tyr, Met, Ile, 0.766, 0.734, 5.0%, 0.738, 0.702; Gln, Arg, Tyr, Lys, Leu, Phe, 0.766, 0.732, 1.3%, 0.733, 0.708; Gln, His, Ala, Cit, Pro, Ile, 0.766, 0.712, 1.1%, 0.737, 0.736; Gln, His, Cit, Met, Ile, Phe, 0.766, 0.708, 0.2%, 0.731, 0.704; Gln, His, Thr, Arg, Tyr, Ile, 0.766, 0.738, 2.8%, 0.762, 0.787; Gln, His, Tyr, Val, Ile, Trp, 0.766, 0.739, 5.1%, 0.750, 0.755; Gln, Thr, Tyr, Lys, Ile, Phe, 0.766, 0.727, 6.1%, 0.725, 0.738; Gly, Gln, Ala, Tyr, Ile, Phe, 0.766, 0.723, 5.7%, 0.726, 0.706; Gly, Gln, Pro, Tyr, Ile, Phe, 0.766, 0.722, 4.8%, 0.726, 0.712; Gly, Gln, Thr, Tyr, Leu, Phe, 0.766, 0.726, 2.4%, 0.721, 0.673; Gly, Gln, Tyr, Lys, Ile, Phe, 0.766, 0.717, 5.0%, 0.701, 0.712; Gly, Gln, Tyr, Lys, Leu, Phe, 0.766, 0.720, 2.4%, 0.704, 0.682; Ser, Gln, Tyr, Orn, Ile, Phe, 0.766, 0.724, 4.8%, 0.735, 0.716; Arg, Pro, Tyr, Lys, Ile, Phe, 0.766, 0.713, 2.2%, 0.714, 0.714; Asn, Cit, Tyr, Lys, Ile, Leu, 0.766, 0.717, 4.0%, 0.713, 0.714; Asn, Gln, His, Ala, Ile, Leu, 0.766, 0.711, 1.7%, 0.734, 0.710; Asn, Gln, His, Ala, Orn, Ile, 0.766, 0.699, 2.0%, 0.722, 0.700; Asn, Gln, His, Ala, Val, Ile, 0.766, 0.710, 1.7%, 0.737, 0.722; Asn, Gln, His, Arg, Lys, Ile, 0.766, 0.694, 2.0%, 0.702, 0.704; Asn, Gln, His, Thr, Ala, Ile, 0.766, 0.710, 1.7%, 0.733, 0.726; Asn, Gln, His, Val, Ile, Leu, 0.766, 0.713, 1.1%, 0.739, 0.722; Asn, Gln, Tyr, Orn, Leu, Phe, 0.766, 0.731, 2.4%, 0.728, 0.669; Asn, Gly, Arg, Orn, Lys, Ile, 0.766, 0.666, 2.9%, 0.656, 0.667; Cit, Arg, Tyr, Orn, Lys, Ile, 0.766, 0.704, 3.7%, 0.715, 0.750; Gln, Arg, Lys, Ile, Leu, Phe, 0.766, 0.684, 1.1%, 0.682, 0.688; Gln, Arg, Orn, Lys, Ile, Trp, 0.766, 0.679, 1.1%, 0.675, 0.710; Gln, Arg, Tyr, Met, Lys, Ile, 0.766, 0.728, 3.7%, 0.733, 0.763; Gln, His, Arg, Orn, Ile, Phe, 0.766, 0.693, 0.4%, 0.718, 0.682; Gln, His, Cit, Arg, Pro, Ile, 0.766, 0.712, 1.1%, 0.735, 0.736; Gln, His, Cit, Pro, Ile, Leu, 0.766, 0.712, 1.1%, 0.735, 0.734; Gln, His, Thr, Tyr, Ile, Trp, 0.766, 0.744, 5.9%, 0.758, 0.759; Gln, His, Tyr, Lys, Leu, Phe, 0.766, 0.733, 1.5%, 0.730, 0.722; Gln, Pro, Tyr, Lys, Leu, Phe, 0.766, 0.726, 2.6%, 0.719, 0.690; Gly, Arg, Tyr, Val, Lys, Ile, 0.766, 0.711, 4.2%, 0.704, 0.728; Gly, Cit, Arg, Tyr, Lys, Ile, 0.766, 0.709, 2.6%, 0.706, 0.736; Gly, Gln, His, Arg, Tyr, Ile, 0.766, 0.732, 2.8%, 0.753, 0.767; His, Arg, Tyr, Met, Ile, Phe, 0.766, 0.727, 2.6%, 0.735, 0.702; Ser, Gln, Pro, Tyr, Ile, Phe, 0.766, 0.720, 5.5%, 0.732, 0.718; Ser, Gln, Tyr, Met, Lys, Ile, 0.766, 0.715, 5.3%, 0.706, 0.744; Asn, Gln, Arg, Lys, Ile, Trp, 0.765, 0.682, 2.2%, 0.678, 0.706; Asn, Gln, Cit, Tyr, Lys, Ile, 0.765, 0.723, 5.3%, 0.726, 0.750; Asn, Gln, His, Ala, Pro, Ile, 0.765, 0.711, 1.7%, 0.734, 0.714; Asn, Gln, His, Cit, Ile, Leu, 0.765, 0.716, 0.7%, 0.743, 0.722; Asn, Gln, His, Tyr, Leu, Phe, 0.765, 0.740, 1.1%, 0.746, 0.688; Asn, Gln, Tyr, Ile, Leu, Trp, 0.765, 0.736, 6.6%, 0.735, 0.720; Asn, Gln, Tyr, Val, Leu, Phe, 0.765, 0.736, 1.8%, 0.737, 0.671; Asn, Gly, Arg, Lys, Ile, Phe, 0.765, 0.675, 1.8%, 0.662, 0.655; Asn, Gly, Gln, Tyr, Ile, Leu, 0.765, 0.723, 5.0%, 0.717, 0.698; Asn, Gly, Gln, Tyr, Leu, Trp, 0.765, 0.731, 4.6%, 0.713, 0.686; Asn, His, Cit, Tyr, Met, Ile, 0.765, 0.735, 2.9%, 0.748, 0.728; Gln, Arg, Lys, Ile, Phe, Trp, 0.765, 0.682, 1.1%, 0.679, 0.690; Gln, Arg, Met, Lys, Ile, Trp, 0.765, 0.690, 1.7%, 0.687, 0.726; Gln, His, Arg, Tyr, Val, Ile, 0.765, 0.735, 2.4%, 0.760, 0.785; Gln, His, Cit, Orn, Ile, Trp, 0.765, 0.696, 2.4%, 0.713, 0.690; Gln, His, Pro, Tyr, Leu, Phe, 0.765, 0.731, 2.2%, 0.735, 0.696; Gln, His, Thr, Cit, Orn, Ile, 0.765, 0.695, 1.1%, 0.710, 0.728; Gln, Pro, Tyr, Ile, Phe, Trp, 0.765, 0.734, 6.8%, 0.745, 0.718; Gln, Thr, Tyr, Ile, Leu, Phe, 0.765, 0.732, 2.9%, 0.737, 0.698; Gln, Tyr, Orn, Leu, Phe, Trp, 0.765, 0.729, 3.3%, 0.726, 0.688; Gly, Gln, Tyr, Ile, Phe, Trp, 0.765, 0.722, 6.2%, 0.723, 0.710; Gly, Gln, Tyr, Orn, Leu, Phe, 0.765, 0.723, 2.6%, 0.715, 0.682; Gly, His, Arg, Tyr, Lys, Ile, 0.765, 0.710, 2.9%, 0.707, 0.734; His, Thr, Cit, Tyr, Ile, Phe, 0.765, 0.726, 2.6%, 0.738, 0.704; Ser, Arg, Tyr, Lys, Ile, Trp, 0.765, 0.706, 5.3%, 0.691, 0.724; Ser, Asn, Gln, Tyr, Ile, Leu, 0.765, 0.721, 3.5%, 0.724, 0.716; Ser, Gln, His, Arg, Tyr, Ile, 0.765, 0.726, 2.4%, 0.751, 0.785; Ser, Gln, Thr, Tyr, Ile, Phe, 0.765, 0.721, 4.6%, 0.734, 0.716; Ser, His, Arg, Tyr, Lys, Ile, 0.765, 0.708, 2.9%, 0.706, 0.751; Asn, Gln, His, Arg, Val, Ile, 0.764, 0.715, 1.1%, 0.743, 0.726; Asn, Gln, His, Cit, Met, Ile, 0.764, 0.716, 0.6%, 0.742, 0.720; Asn, Gln, His, Thr, Cit, Ile, 0.764, 0.712, 0.9%, 0.738, 0.726; Asn, Gln, His, Val, Orn, Ile, 0.764, 0.697, 2.0%, 0.720, 0.704; Asn, Gly, Gln, Tyr, Lys, Ile, 0.764, 0.717, 6.2%, 0.698, 0.708; Asn, His, Cit, Tyr, Orn, Ile, 0.764, 0.714, 3.5%, 0.730, 0.728; Gln, Arg, Val, Lys, Ile, Phe, 0.764, 0.681, 1.1%, 0.681, 0.702; Gln, His, Ala, Cit, Tyr, Ile, 0.764, 0.736, 2.6%, 0.762, 0.797; Gln, His, Arg, Ile, Phe, Trp, 0.764, 0.709, 0.0%, 0.733, 0.684; Gln, His, Arg, Pro, Ile, Phe, 0.764, 0.707, 0.2%, 0.732, 0.673; Gln, His, Cit, Pro, Ile, Trp, 0.764, 0.715, 1.5%, 0.733, 0.724; Gln, His, Ile, Leu, Phe, Trp, 0.764, 0.709, 0.2%, 0.728, 0.686; Gln, His, Pro, Tyr, Ile, Trp, 0.764, 0.741, 5.9%, 0.756, 0.767; Gln, His, Thr, Cit, Pro, Ile, 0.764, 0.712, 1.1%, 0.735, 0.744; Gln, His, Tyr, Met, Leu, Phe, 0.764, 0.737, 1.5%, 0.743, 0.702; Gln, Pro, Tyr, Leu, Phe, Trp, 0.764, 0.733, 4.0%, 0.728, 0.682; Gln, Thr, Arg, Lys, Ile, Trp, 0.764, 0.687, 1.5%, 0.683, 0.726; Gln, Tyr, Met, Orn, Leu, Phe, 0.764, 0.725, 2.4%, 0.728, 0.677; Gly, Gln, His, Cit, Tyr, Ile, 0.764, 0.731, 2.4%, 0.752, 0.783; Gly, Gln, Tyr, Lys, Ile, Leu, 0.764, 0.717, 4.0%, 0.708, 0.726; Gly, Gln, Tyr, Lys, Leu, Trp, 0.764, 0.726, 5.1%, 0.698, 0.710; His, Arg, Tyr, Orn, Ile, Phe, 0.764, 0.718, 3.1%, 0.730, 0.694; Ser, Asn, Gln, His, Ile, Phe, 0.764, 0.690, 0.4%, 0.719, 0.680; Ser, Asn, Gln, His, Orn, Ile, 0.764, 0.690, 0.9%, 0.708, 0.708; Ser, Gly, Gln, Tyr, Ile, Phe, 0.764, 0.716, 5.5%, 0.721, 0.710; Asn, Arg, Tyr, Lys, Leu, Phe, 0.764, 0.727, 1.5%, 0.718, 0.667; Asn, Cit, Tyr, Orn, Lys, Ile, 0.764, 0.709, 5.7%, 0.707, 0.728; Asn, Gln, Ala, Arg, Lys, Ile, 0.764, 0.678, 2.8%, 0.677, 0.712; Asn, Gln, His, Cit, Tyr, Ile, 0.764, 0.737, 2.2%, 0.765, 0.779; Asn, Gln, His, Thr, Orn, Ile, 0.764, 0.699, 2.2%, 0.722, 0.698; Asn, Gln, His, Val, Met, Ile, 0.764, 0.712, 1.3%, 0.737, 0.722; Asn, Gln, Tyr, Orn, Ile, Phe, 0.764, 0.734, 5.7%, 0.746, 0.704; Asn, Gln, Val, Lys, Ile, Leu, 0.764, 0.678, 1.8%, 0.663, 0.686; Asn, Gly, Cit, Pro, Tyr, Ile, 0.764, 0.725, 7.4%, 0.726, 0.718; Gln, Arg, Orn, Lys, Ile, Phe, 0.764, 0.680, 1.1%, 0.671, 0.679; Gln, Cit, Tyr, Lys, Ile, Phe, 0.764, 0.723, 3.7%, 0.726, 0.730; Gln, His, Ala, Cit, Orn, Ile, 0.764, 0.693, 1.1%, 0.706, 0.726; Gln, His, Ala, Tyr, Met, Ile, 0.764, 0.741, 5.7%, 0.757, 0.748; Gln, His, Ala, Tyr, Val, Ile, 0.764, 0.732, 2.8%, 0.752, 0.771; Gln, His, Arg, Val, Ile, Phe, 0.764, 0.708, 0.0%, 0.731, 0.682; Gln, His, Cit, Pro, Tyr, Ile, 0.764, 0.736, 2.8%, 0.760, 0.799; Gln, His, Pro, Tyr, Met, Ile, 0.764, 0.743, 5.5%, 0.758, 0.750; Gln, His, Thr, Cit, Val, Ile, 0.764, 0.712, 0.7%, 0.740, 0.753; Gln, His, Thr, Tyr, Met, Ile, 0.764, 0.743, 5.5%, 0.757, 0.750; Gln, His, Tyr, Orn, Ile, Leu, 0.764, 0.728, 2.4%, 0.749, 0.767; Gln, His, Tyr, Val, Orn, Ile, 0.764, 0.727, 2.4%, 0.750, 0.773; Gln, His, Val, Ile, Leu, Phe, 0.764, 0.706, 0.0%, 0.729, 0.684; Gln, Tyr, Met, Lys, Ile, Leu, 0.764, 0.727, 4.0%, 0.720, 0.734; Gly, Ala, Arg, Tyr, Lys, Ile, 0.764, 0.709, 3.7%, 0.705, 0.736; Gly, Arg, Tyr, Orn, Lys, Ile, 0.764, 0.708, 3.9%, 0.705, 0.738; Gly, Gln, Arg, Lys, Ile, Phe, 0.764, 0.680, 1.3%, 0.666, 0.667; Gly, Gln, Cit, Tyr, Ile, Leu, 0.764, 0.723, 3.5%, 0.722, 0.730; Gly, Gln, His, Arg, Ile, Phe, 0.764, 0.701, 0.0%, 0.725, 0.680; Gly, Gln, His, Tyr, Leu, Trp, 0.764, 0.736, 5.1%, 0.724, 0.704; His, Ala, Tyr, Met, Ile, Phe, 0.764, 0.724, 2.0%, 0.726, 0.682; His, Arg, Tyr, Orn, Lys, Ile, 0.764, 0.709, 3.1%, 0.712, 0.738; His, Pro, Tyr, Met, Lys, Ile, 0.764, 0.725, 6.4%, 0.713, 0.708; His, Thr, Tyr, Met, Ile, Phe, 0.764, 0.730, 2.2%, 0.732, 0.680; Ser, Arg, Tyr, Met, Lys, Ile, 0.764, 0.714, 4.4%, 0.709, 0.736; Ser, Asn, Gln, Tyr, Lys, Ile, 0.764, 0.709, 7.0%, 0.695, 0.718; Ala, Arg, Tyr, Met, Lys, Ile, 0.763, 0.719, 5.1%, 0.716, 0.740; Arg, Pro, Tyr, Met, Lys, Ile, 0.763, 0.715, 4.8%, 0.710, 0.728; Arg, Tyr, Met, Orn, Lys, Ile, 0.763, 0.719, 5.1%, 0.716, 0.740; Asn, Cit, Tyr, Lys, Ile, Phe, 0.763, 0.716, 5.0%, 0.707, 0.700; Asn, Gln, His, Ala, Arg, Ile, 0.763, 0.710, 1.5%, 0.736, 0.714; Asn, Gln, His, Tyr, Lys, Ile, 0.763, 0.730, 4.6%, 0.735, 0.742; Asn, Gln, His, Tyr, Orn, Leu, 0.763, 0.728, 1.1%, 0.735, 0.722; Asn, Gln, Lys, Ile, Leu, Phe, 0.763, 0.686, 0.4%, 0.662, 0.639; Asn, Gln, Tyr, Ile, Phe, Trp, 0.763, 0.729, 7.0%, 0.741, 0.706; Asn, Gln, Tyr, Lys, Ile, Leu, 0.763, 0.720, 5.9%, 0.715, 0.710; Asn, Gln, Tyr, Met, Lys, Ile, 0.763, 0.723, 6.4%, 0.714, 0.714; Asn, Gly, Arg, Lys, Ile, Leu, 0.763, 0.675, 1.8%, 0.659, 0.661; Asn, Gly, Tyr, Met, Lys, Leu, 0.763, 0.722, 3.1%, 0.692, 0.641; Asn, His, Thr, Lys, Ile, Phe, 0.763, 0.691, 1.3%, 0.670, 0.619; Asn, Tyr, Met, Lys, Ile, Leu, 0.763, 0.722, 6.2%, 0.702, 0.688; Gln, Arg, Lys, Ile, Leu, Trp, 0.763, 0.686, 0.9%, 0.682, 0.728; Gln, Cit, Arg, Lys, Ile, Phe, 0.763, 0.683, 1.1%, 0.681, 0.692; Gln, Cit, Tyr, Leu, Phe, Trp, 0.763, 0.734, 2.6%, 0.732, 0.690; Gln, Cit, Tyr, Orn, Ile, Phe, 0.763, 0.715, 3.9%, 0.733, 0.728; Gln, His, Ala, Cit, Arg, Ile, 0.763, 0.712, 0.9%, 0.736, 0.744; Gln, His, Arg, Ile, Leu, Phe, 0.763, 0.708, 0.0%, 0.730, 0.679; Gln, His, Arg, Tyr, Ile, Leu, 0.763, 0.734, 2.4%, 0.759, 0.783; Gln, His, Cit, Met, Ile, Trp, 0.763, 0.716, 1.7%, 0.735, 0.724; Gln, His, Pro, Tyr, Orn, Ile, 0.763, 0.728, 2.8%, 0.750, 0.777; Gln, His, Thr, Cit, Ile, Phe, 0.763, 0.704, 0.2%, 0.724, 0.702; Gln, His, Tyr, Val, Ile, Leu, 0.763, 0.731, 2.4%, 0.752, 0.771; Gln, His, Val, Ile, Phe, Trp, 0.763, 0.709, 0.2%, 0.732, 0.692; Gln, Tyr, Lys, Ile, Phe, Trp, 0.763, 0.725, 7.2%, 0.718, 0.732; Gly, Arg, Tyr, Lys, Ile, Leu, 0.763, 0.709, 2.9%, 0.702, 0.718; Gly, Gln, Arg, Lys, Ile, Trp, 0.763, 0.681, 1.1%, 0.667, 0.702; Gly, Gln, Thr, Tyr, Ile, Phe, 0.763, 0.723, 6.6%, 0.728, 0.708; Gly, Gln, Tyr, Lys, Ile, Trp, 0.763, 0.719, 7.7%, 0.703, 0.748; Gl

y, Thr, Arg, Tyr, Lys, Ile, 0.763, 0.712, 6.4%, 0.709, 0.724; His, Cit, Arg, Tyr, Ile, Phe, 0.763, 0.722, 2.4%, 0.734, 0.704; His, Tyr, Met, Ile, Phe, Trp, 0.763, 0.727, 2.8%, 0.727, 0.671; Ser, Arg, Tyr, Orn, Lys, Ile, 0.763, 0.706, 3.3%, 0.704, 0.755; Ser, Arg, Tyr, Val, Lys, Ile, 0.763, 0.708, 3.3%, 0.703, 0.748; Ser, Asn, Arg, Lys, Ile, Leu, 0.763, 0.660, 2.2%, 0.648, 0.682; Ser, Asn, Arg, Lys, Ile, Phe, 0.763, 0.657, 1.8%, 0.641, 0.663; Ser, Asn, Cit, Tyr, Lys, Ile, 0.763, 0.708, 5.3%, 0.704, 0.726; Ser, Asn, Gln, Lys, Leu, Phe, 0.763, 0.671, 0.0%, 0.639, 0.602; Ser, Gln, Arg, Lys, Ile, Trp, 0.763, 0.666, 0.7%, 0.650, 0.704; Ser, Gln, His, Ala, Tyr, Ile, 0.763, 0.726, 2.8%, 0.746, 0.773; Ser, Gln, His, Tyr, Orn, Ile, 0.763, 0.725, 2.8%, 0.748, 0.771; Ser, Gln, Tyr, Lys, Ile, Trp, 0.763, 0.708, 7.7%, 0.696, 0.763; Ser, Gln, Tyr, Val, Ile, Phe, 0.763, 0.724, 5.5%, 0.730, 0.714; Arg, Tyr, Val, Lys, Ile, Trp, 0.763, 0.716, 7.4%, 0.704, 0.734; Arg, Tyr, Val, Met, Lys, Ile, 0.763, 0.722, 4.8%, 0.717, 0.742; Asn, Ala, Cit, Tyr, Lys, Ile, 0.763, 0.713, 5.7%, 0.709, 0.722; Asn, Arg, Orn, Lys, Ile, Phe, 0.763, 0.668, 2.2%, 0.662, 0.655; Asn, Gln, Arg, Tyr, Leu, Phe, 0.763, 0.737, 1.7%, 0.738, 0.675; Asn, Gln, His, Ala, Ile, Phe, 0.763, 0.703, 0.4%, 0.727, 0.673; Asn, Gln, His, Thr, Val, Ile, 0.763, 0.711, 1.7%, 0.740, 0.740; Asn, Gln, Thr, Tyr, Leu, Phe, 0.763, 0.738, 2.2%, 0.740, 0.679; Asn, Gln, Tyr, Lys, Leu, Trp, 0.763, 0.733, 3.5%, 0.715, 0.708; Asn, Gly, Cit, Lys, Ile, Leu, 0.763, 0.683, 1.1%, 0.664, 0.665; Asn, Gly, Gln, Ala, Tyr, Ile, 0.763, 0.729, 7.5%, 0.726, 0.710; Asn, Gly, Gln, His, Val, Ile, 0.763, 0.704, 1.3%, 0.728, 0.704; Asn, Gly, Gln, Lys, Leu, Phe, 0.763, 0.677, 0.0%, 0.640, 0.580; Asn, Gly, Gln, Thr, Lys, Leu, 0.763, 0.681, 0.2%, 0.645, 0.602; Asn, Thr, Arg, Lys, Ile, Phe, 0.763, 0.677, 1.8%, 0.670, 0.667; Gln, Ala, Tyr, Met, Ile, Phe, 0.763, 0.728, 6.1%, 0.740, 0.710; Gln, Arg, Tyr, Lys, Ile, Trp, 0.763, 0.728, 7.5%, 0.728, 0.771; Gln, Cit, Arg, Orn, Lys, Ile, 0.763, 0.679, 1.5%, 0.677, 0.718; Gln, His, Ala, Cit, Ile, Phe, 0.763, 0.702, 0.4%, 0.725, 0.694; Gln, His, Ala, Pro, Tyr, Ile, 0.763, 0.732, 2.6%, 0.752, 0.777; Gln, His, Cit, Tyr, Ile, Leu, 0.763, 0.736, 2.4%, 0.761, 0.793; Gln, Pro, Tyr, Ile, Leu, Trp, 0.763, 0.737, 6.2%, 0.733, 0.728; Gln, Thr, Arg, Lys, Ile, Phe, 0.763, 0.683, 0.9%, 0.678, 0.688; Gln, Tyr, Val, Leu, Phe, Trp, 0.763, 0.733, 2.6%, 0.728, 0.684; Gly, Gln, Cit, Pro, Orn, Ile, 0.763, 0.682, 1.3%, 0.684, 0.679; Gly, Gln, Cit, Tyr, Ile, Phe, 0.763, 0.719, 3.9%, 0.724, 0.710; Gly, Gln, His, Pro, Tyr, Ile, 0.763, 0.731, 3.1%, 0.747, 0.769; Gly, Gln, Pro, Tyr, Leu, Trp, 0.763, 0.728, 5.0%, 0.710, 0.700; Gly, Gln, Tyr, Met, Ile, Leu, 0.763, 0.724, 4.8%, 0.714, 0.698; His, Ala, Tyr, Met, Lys, Ile, 0.763, 0.724, 6.2%, 0.711, 0.708; His, Thr, Tyr, Lys, Ile, Phe, 0.763, 0.723, 2.9%, 0.723, 0.700; His, Tyr, Met, Orn, Lys, Ile, 0.763, 0.727, 5.7%, 0.711, 0.720; Ser, Arg, Tyr, Lys, Ile, Leu, 0.763, 0.707, 3.1%, 0.702, 0.746; Ser, Asn, Gly, Cit, Tyr, Ile, 0.763, 0.723, 6.4%, 0.725, 0.716; Ser, Gln, Ala, Tyr, Ile, Phe, 0.763, 0.714, 5.5%, 0.728, 0.720; Ser, Gln, Arg, Lys, Ile, Phe, 0.763, 0.665, 0.4%, 0.652, 0.692; Ser, Gln, Arg, Val, Lys, Ile, 0.763, 0.664, 0.6%, 0.659, 0.732; Ser, Gln, Tyr, Leu, Phe, Trp, 0.763, 0.733, 2.6%, 0.728, 0.686; Ser, Thr, Arg, Tyr, Lys, Ile, 0.763, 0.704, 7.0%, 0.703, 0.755; Arg, Tyr, Met, Lys, Ile, Leu, 0.762, 0.722, 4.0%, 0.715, 0.730; Asn, Arg, Lys, Ile, Leu, Phe, 0.762, 0.676, 1.7%, 0.667, 0.665; Asn, Gln, Arg, Lys, Ile, Leu, 0.762, 0.681, 2.2%, 0.677, 0.706; Asn, Gln, Arg, Tyr, Ile, Leu, 0.762, 0.732, 3.3%, 0.740, 0.718; Asn, Gln, Arg, Val, Lys, Ile, 0.762, 0.679, 2.4%, 0.680, 0.730; Asn, Gln, His, Arg, Ile, Leu, 0.762, 0.715, 0.9%, 0.739, 0.722; Asn, Gln, His, Tyr, Val, Orn, 0.762, 0.728, 3.3%, 0.728, 0.718; Asn, Gln, Thr, Arg, Lys, Ile, 0.762, 0.683, 2.0%, 0.680, 0.706; Asn, Gln, Thr, Lys, Leu, Phe, 0.762, 0.679, 0.0%, 0.649, 0.604; Asn, Gln, Val, Lys, Ile, Phe, 0.762, 0.676, 1.7%, 0.657, 0.665; Asn, Gly, Cit, Tyr, Met, Ile, 0.762, 0.726, 8.1%, 0.720, 0.708; Asn, Gly, Cit, Tyr, Orn, Ile, 0.762, 0.713, 6.2%, 0.719, 0.716; Asn, Gly, Cit, Tyr, Val, Ile, 0.762, 0.726, 6.4%, 0.722, 0.708; Asn, Gly, Gln, Cit, Tyr, Leu, 0.762, 0.726, 3.1%, 0.716, 0.680; Asn, Gly, Gln, His, Lys, Ile, 0.762, 0.691, 2.2%, 0.676, 0.665; Asn, Gly, Gln, His, Orn, Ile, 0.762, 0.693, 1.8%, 0.713, 0.684; Asn, Gly, Gln, Tyr, Ile, Trp, 0.762, 0.726, 6.6%, 0.723, 0.720; Asn, Gly, His, Cit, Tyr, Ile, 0.762, 0.722, 4.0%, 0.734, 0.732; Asn, His, Ala, Cit, Tyr, Ile, 0.762, 0.728, 3.7%, 0.744, 0.730; Asn, His, Arg, Orn, Lys, Ile, 0.762, 0.680, 1.5%, 0.681, 0.671; Asn, His, Arg, Tyr, Val, Ile, 0.762, 0.731, 4.4%, 0.742, 0.718; Asn, His, Cit, Pro, Tyr, Ile, 0.762, 0.728, 3.9%, 0.744, 0.740; Asn, His, Tyr, Met, Ile, Leu, 0.762, 0.736, 4.0%, 0.738, 0.702; Asn, Thr, Cit, Tyr, Lys, Ile, 0.762, 0.717, 7.5%, 0.711, 0.716; Gln, Ala, Tyr, Ile, Phe, Trp, 0.762, 0.729, 6.6%, 0.739, 0.706; Gln, Cit, Arg, Lys, Ile, Trp, 0.762, 0.685, 0.7%, 0.680, 0.728; Gln, His, Ala, Arg, Ile, Phe, 0.762, 0.702, 0.2%, 0.723, 0.692; Gln, His, Ala, Cit, Ile, Leu, 0.762, 0.711, 0.9%, 0.735, 0.742; Gln, His, Cit, Pro, Met, Ile, 0.762, 0.710, 1.1%, 0.732, 0.726; Gln, His, Pro, Tyr, Leu, Trp, 0.762, 0.734, 3.9%, 0.729, 0.712; Gln, His, Tyr, Met, Ile, Leu, 0.762, 0.740, 5.0%, 0.753, 0.740; Gln, His, Tyr, Val, Met, Ile, 0.762, 0.741, 5.3%, 0.756, 0.746; Gln, Tyr, Met, Ile, Phe, Trp, 0.762, 0.730, 6.4%, 0.740, 0.704; Gln, Tyr, Orn, Ile, Phe, Trp, 0.762, 0.733, 6.6%, 0.744, 0.714; Gly, Arg, Pro, Tyr, Lys, Ile, 0.762, 0.706, 4.2%, 0.700, 0.726; Gly, Gln, Arg, Tyr, Ile, Phe, 0.762, 0.720, 3.5%, 0.728, 0.704; Gly, Gln, His, Cit, Pro, Ile, 0.762, 0.705, 1.3%, 0.720, 0.712; Gly, Gln, His, Tyr, Met, Leu, 0.762, 0.731, 3.1%, 0.729, 0.700; Gly, Gln, Tyr, Orn, Leu, Trp, 0.762, 0.727, 5.0%, 0.709, 0.698; Gly, Gln, Tyr, Val, Ile, Phe, 0.762, 0.723, 5.5%, 0.718, 0.698; Gly, His, Tyr, Met, Lys, Ile, 0.762, 0.720, 6.1%, 0.702, 0.684; Ser, Arg, Pro, Tyr, Lys, Ile, 0.762, 0.705, 4.6%, 0.703, 0.748; Ser, Asn, Gln, Tyr, Ile, Phe, 0.762, 0.719, 4.8%, 0.728, 0.712; Ser, Gln, Ala, Arg, Lys, Ile, 0.762, 0.666, 0.6%, 0.661, 0.722; Ser, Gln, His, Cit, Ile, Phe, 0.762, 0.691, 0.4%, 0.710, 0.692; Ser, Gly, Arg, Tyr, Lys, Ile, 0.762, 0.705, 3.5%, 0.700, 0.738; Ser, Gly, Gln, Tyr, Leu, Phe, 0.762, 0.731, 2.6%, 0.723, 0.673; Thr, Arg, Tyr, Met, Lys, Ile, 0.762, 0.723, 4.8%, 0.719, 0.738; Ala, Tyr, Met, Lys, Ile, Phe, 0.761, 0.717, 6.8%, 0.700, 0.688; Asn, Arg, Lys, Ile, Phe, Trp, 0.761, 0.676, 1.7%, 0.667, 0.663; Asn, Arg, Orn, Lys, Ile, Leu, 0.761, 0.668, 2.8%, 0.660, 0.665; Asn, Arg, Orn, Lys, Ile, Trp, 0.761, 0.666, 2.8%, 0.662, 0.669; Asn, Cit, Arg, Lys, Ile, Phe, 0.761, 0.676, 2.0%, 0.671, 0.671; Asn, Gln, Cit, Orn, Lys, Ile, 0.761, 0.678, 2.8%, 0.665, 0.673; Asn, Gln, His, Ala, Met, Ile, 0.761, 0.708, 1.5%, 0.730, 0.704; Asn, Gln, His, Arg, Pro, Ile, 0.761, 0.713, 1.5%, 0.738, 0.720; Asn, Gln, His, Pro, Met, Ile, 0.761, 0.712, 1.3%, 0.737, 0.712; Asn, Gln, His, Pro, Orn, Ile, 0.761, 0.697, 2.4%, 0.720, 0.696; Asn, Gln, Pro, Tyr, Ile, Phe, 0.761, 0.731, 5.9%, 0.742, 0.706; Asn, Gln, Pro, Tyr, Leu, Phe, 0.761, 0.731, 2.4%, 0.732, 0.675; Asn, Gln, Tyr, Met, Ile, Phe, 0.761, 0.729, 6.2%, 0.742, 0.706; Asn, Gly, Cit, Pro, Lys, Ile, 0.761, 0.679, 1.7%, 0.664, 0.680; Asn, Gly, Cit, Val, Lys, Ile, 0.761, 0.682, 1.5%, 0.664, 0.671; Asn, Gly, Gln, Pro, Tyr, Leu, 0.761, 0.726, 3.7%, 0.715, 0.680; Asn, Gly, Gln, Tyr, Val, Ile, 0.761, 0.723, 6.6%, 0.715, 0.708; Asn, Gly, His, Cit, Lys, Ile, 0.761, 0.691, 3.9%, 0.682, 0.661; Asn, His, Arg, Tyr, Met, Ile, 0.761, 0.736, 2.9%, 0.748, 0.718; Asn, His, Cit, Arg, Tyr, Ile, 0.761, 0.732, 3.5%, 0.752, 0.734; Asn, His, Cit, Lys, Ile, Phe, 0.761, 0.689, 1.1%, 0.674, 0.637; Asn, His, Cit, Tyr, Ile, Leu, 0.761, 0.726, 3.1%, 0.737, 0.724; Asn, His, Cit, Tyr, Lys, Ile, 0.761, 0.714, 4.8%, 0.715, 0.722; Cit, Arg, Tyr, Lys, Ile, Trp, 0.761, 0.718, 5.1%, 0.712, 0.740; Gln, His, Ala, Cit, Ile, Trp, 0.761, 0.709, 1.3%, 0.727, 0.722; Gln, His, Ala, Pro, Ile, Trp, 0.761, 0.710, 1.8%, 0.728, 0.716; Gln, His, Ala, Tyr, Ile, Leu, 0.761, 0.732, 2.4%, 0.751, 0.769; Gln, His, Ala, Tyr, Leu, Trp, 0.761, 0.731, 3.3%, 0.727, 0.730; Gln, His, Arg, Tyr, Met, Ile, 0.761, 0.739, 5.0%, 0.760, 0.753; Gln, His, Cit, Arg, Val, Ile, 0.761, 0.713, 0.7%, 0.737, 0.736; Gln, His, Cit, Lys, Ile, Phe, 0.761, 0.698, 0.4%, 0.701, 0.677; Gln, His, Thr, Arg, Ile, Phe, 0.761, 0.704, 0.0%, 0.730, 0.702; Gln, His, Thr, Cit, Tyr, Ile, 0.761, 0.734, 2.6%, 0.761, 0.793; Gln, Pro, Tyr, Met, Ile, Phe, 0.761, 0.731, 5.3%, 0.743, 0.708; Gln, Pro, Tyr, Met, Leu, Phe, 0.761, 0.731, 3.3%, 0.732, 0.684; Gln, Thr, Ala, Tyr, Ile, Phe, 0.761, 0.728, 6.2%, 0.740, 0.708; Gln, Thr, Tyr, Met, Ile, Phe, 0.761, 0.730, 6.4%, 0.743, 0.708; Gln, Tyr, Met, Ile, Leu, Trp, 0.761, 0.735, 5.3%, 0.731, 0.718; Gln, Tyr, Orn, Lys, Ile, Phe, 0.761, 0.728, 5.3%, 0.722, 0.730; Gln, Tyr, Val, Met, Ile, Phe, 0.761, 0.733, 5.7%, 0.736, 0.702; Gly, Gln, Ala, Tyr, Ile, Leu, 0.761, 0.723, 3.7%, 0.721, 0.724; Gly, Gln, Ala, Tyr, Leu, Phe, 0.761, 0.717, 2.2%, 0.711, 0.679; Gly, Gln, Ala, Tyr, Leu, Trp, 0.761, 0.728, 5.0%, 0.711, 0.696; Gly, Gln, Arg, Tyr, Lys, Leu, 0.761, 0.722, 2.2%, 0.713, 0.720; Gly, Gln, Cit, Tyr, Ile, Trp, 0.761, 0.726, 5.5%, 0.724, 0.744; Gly, Gln, Cit, Tyr, Leu, Phe, 0.761, 0.720, 2.2%, 0.710, 0.684; Gly, Gln, Cit, Tyr, Lys, Leu, 0.761, 0.721, 2.9%, 0.711, 0.728; Gly, His, Cit, Tyr, Ile, Phe, 0.761, 0.713, 2.8%, 0.713, 0.710; Pro, Tyr, Met, Lys, Ile, Phe, 0.761, 0.716, 7.9%, 0.697, 0.677; Ser, Gln, His, Tyr, Ile, Leu, 0.761, 0.725, 2.8%, 0.745, 0.769; Ser, Gly, Gln, Arg, Lys, Ile, 0.761, 0.671, 0.6%, 0.657, 0.710; Ser, His, Tyr, Met, Lys, Ile, 0.761, 0.722, 6.4%, 0.709, 0.704; Thr, Arg, Tyr, Lys, Ile, Trp, 0.761, 0.719, 8.5%, 0.707, 0.732; Arg, Tyr, Ile, Leu, Phe, Trp, 0.761, 0.724, 3.1%, 0.720, 0.663; Arg, Tyr, Val, Orn, Lys, Ile, 0.761, 0.712, 4.0%, 0.709, 0.736; Asn, Ala, Arg, Lys, Ile, Phe, 0.761, 0.669, 2.0%, 0.665, 0.669; Asn, Arg, Met, Lys, Ile, Phe, 0.761, 0.676, 1.7%, 0.665, 0.655; Asn, Arg, Val, Orn, Lys, Ile, 0.761, 0.662, 3.5%, 0.658, 0.673; Asn, Cit, Arg, Pro, Tyr, Lys, 0.761, 0.705, 6.6%, 0.692, 0.744; Asn

, Gln, Cit, Lys, Ile, Phe, 0.761, 0.684, 0.9%, 0.668, 0.657; Asn, Gln, His, Arg, Orn, Ile, 0.761, 0.697, 1.1%, 0.723, 0.696; Asn, Gln, His, Lys, Ile, Leu, 0.761, 0.698, 2.9%, 0.697, 0.716; Asn, Gln, His, Orn, Ile, Leu, 0.761, 0.697, 2.4%, 0.717, 0.692; Asn, Gln, His, Pro, Ile, Leu, 0.761, 0.711, 1.5%, 0.734, 0.716; Asn, Gln, His, Thr, Met, Ile, 0.761, 0.712, 1.1%, 0.735, 0.716; Asn, Gln, His, Thr, Tyr, Leu, 0.761, 0.741, 2.0%, 0.744, 0.718; Asn, Gln, Tyr, Met, Ile, Leu, 0.761, 0.735, 5.9%, 0.735, 0.694; Asn, Gln, Tyr, Orn, Leu, Trp, 0.761, 0.727, 5.0%, 0.718, 0.698; Asn, Gln, Tyr, Orn, Lys, Leu, 0.761, 0.722, 2.6%, 0.710, 0.710; Asn, Gly, Arg, Met, Lys, Ile, 0.761, 0.674, 1.7%, 0.660, 0.669; Asn, Gly, Gln, His, Ala, Ile, 0.761, 0.703, 1.3%, 0.724, 0.696; Asn, Gly, Gln, His, Ile, Leu, 0.761, 0.706, 1.1%, 0.725, 0.698; Asn, Gly, Gln, Orn, Lys, Ile, 0.761, 0.678, 2.4%, 0.650, 0.663; Asn, Gly, Gln, Orn, Lys, Leu, 0.761, 0.670, 0.2%, 0.635, 0.600; Asn, Gly, Gln, Tyr, Val, Leu, 0.761, 0.723, 2.8%, 0.715, 0.673; Asn, Gly, Thr, Cit, Lys, Ile, 0.761, 0.681, 1.5%, 0.663, 0.671; Asn, Gly, Thr, Cit, Tyr, Ile, 0.761, 0.724, 8.1%, 0.727, 0.708; Asn, His, Arg, Tyr, Orn, Ile, 0.761, 0.723, 3.3%, 0.741, 0.718; Asn, His, Cit, Pro, Lys, Ile, 0.761, 0.690, 4.2%, 0.685, 0.694; Asn, His, Lys, Ile, Leu, Phe, 0.761, 0.688, 1.5%, 0.669, 0.621; Asn, His, Met, Lys, Ile, Phe, 0.761, 0.687, 1.5%, 0.667, 0.613; Asn, Thr, Tyr, Lys, Leu, Phe, 0.761, 0.733, 3.7%, 0.714, 0.655; Gln, Ala, Tyr, Lys, Ile, Phe, 0.761, 0.720, 5.1%, 0.714, 0.726; Gln, Cit, Tyr, Orn, Leu, Trp, 0.761, 0.717, 3.5%, 0.711, 0.698; Gln, His, Cit, Met, Ile, Leu, 0.761, 0.711, 0.7%, 0.735, 0.730; Gln, His, Cit, Tyr, Val, Ile, 0.761, 0.735, 2.6%, 0.760, 0.799; Gln, His, Thr, Ala, Tyr, Ile, 0.761, 0.737, 3.3%, 0.757, 0.771; Gln, His, Tyr, Val, Leu, Trp, 0.761, 0.736, 3.5%, 0.726, 0.718; Gln, Thr, Tyr, Orn, Leu, Phe, 0.761, 0.725, 2.4%, 0.732, 0.682; Gln, Thr, Tyr, Val, Ile, Phe, 0.761, 0.735, 6.2%, 0.740, 0.700; Gln, Tyr, Met, Leu, Phe, Trp, 0.761, 0.734, 2.8%, 0.729, 0.677; Gln, Tyr, Val, Lys, Leu, Phe, 0.761, 0.723, 1.5%, 0.719, 0.700; Gly, Gln, Arg, Orn, Lys, Ile, 0.761, 0.677, 1.1%, 0.668, 0.688; Gly, Gln, His, Cit, Tyr, Leu, 0.761, 0.724, 1.8%, 0.719, 0.730; Gly, Gln, His, Orn, Ile, Phe, 0.761, 0.692, 0.4%, 0.712, 0.677; Gly, Gln, His, Tyr, Ile, Leu, 0.761, 0.729, 2.9%, 0.743, 0.744; Gly, Gln, His, Tyr, Lys, Leu, 0.761, 0.723, 2.9%, 0.708, 0.730; Gly, Gln, His, Tyr, Val, Leu, 0.761, 0.726, 2.4%, 0.721, 0.736; Gly, Gln, Tyr, Val, Ile, Leu, 0.761, 0.720, 3.7%, 0.720, 0.724; Gly, His, Arg, Tyr, Ile, Phe, 0.761, 0.717, 3.5%, 0.726, 0.692; Gly, His, Tyr, Met, Ile, Phe, 0.761, 0.723, 2.4%, 0.721, 0.677; Gly, Tyr, Met, Lys, Ile, Phe, 0.761, 0.714, 7.7%, 0.692, 0.679; His, Arg, Pro, Tyr, Ile, Phe, 0.761, 0.723, 3.3%, 0.733, 0.694; His, Arg, Tyr, Ile, Leu, Phe, 0.761, 0.723, 2.8%, 0.730, 0.690; His, Cit, Tyr, Met, Ile, Phe, 0.761, 0.724, 2.6%, 0.730, 0.702; His, Tyr, Met, Orn, Ile, Phe, 0.761, 0.729, 2.6%, 0.727, 0.679; Ser, Ala, Arg, Tyr, Lys, Ile, 0.761, 0.706, 3.3%, 0.703, 0.753; Ser, Asn, Arg, Orn, Lys, Ile, 0.761, 0.658, 3.3%, 0.649, 0.684; Ser, Cit, Arg, Tyr, Lys, Ile, 0.761, 0.707, 2.8%, 0.709, 0.753; Ser, Gln, Cit, Arg, Lys, Ile, 0.761, 0.669, 0.4%, 0.660, 0.714; Ser, Gln, His, Tyr, Val, Ile, 0.761, 0.725, 2.8%, 0.747, 0.769; Ser, Gly, Gln, Tyr, Lys, Ile, 0.761, 0.711, 5.0%, 0.701, 0.746; Tyr, Met, Lys, Ile, Phe, Trp, 0.761, 0.718, 7.7%, 0.700, 0.680; Asn, Arg, Val, Lys, Ile, Phe, 0.760, 0.671, 2.0%, 0.662, 0.661; Asn, Cit, Arg, Orn, Lys, Ile, 0.760, 0.666, 3.1%, 0.662, 0.671; Asn, Cit, Pro, Orn, Lys, Ile, 0.760, 0.672, 1.8%, 0.659, 0.667; Asn, Cit, Tyr, Val, Lys, Ile, 0.760, 0.715, 5.7%, 0.712, 0.728; Asn, Cit, Val, Lys, Ile, Leu, 0.760, 0.682, 1.5%, 0.670, 0.677; Asn, Gln, Cit, Val, Lys, Ile, 0.760, 0.680, 1.8%, 0.671, 0.706; Asn, Gln, Orn, Lys, Ile, Phe, 0.760, 0.677, 1.3%, 0.656, 0.649; Asn, Gln, Pro, Tyr, Lys, Ile, 0.760, 0.722, 6.6%, 0.716, 0.716; Asn, Gln, Thr, Tyr, Ile, Phe, 0.760, 0.731, 6.1%, 0.744, 0.704; Asn, Gln, Tyr, Val, Ile, Leu, 0.760, 0.728, 3.3%, 0.735, 0.712; Asn, Gly, Arg, Pro, Tyr, Lys, 0.760, 0.705, 6.6%, 0.690, 0.740; Asn, Gly, Cit, Tyr, Lys, Ile, 0.760, 0.707, 7.4%, 0.696, 0.710; Asn, Gly, Gln, Arg, Lys, Ile, 0.760, 0.677, 2.8%, 0.661, 0.669; Asn, Gly, Gln, Cit, Lys, Ile, 0.760, 0.681, 1.3%, 0.658, 0.663; Asn, Gly, Gln, Lys, Ile, Trp, 0.760, 0.678, 2.0%, 0.653, 0.665; Asn, Gly, His, Arg, Tyr, Ile, 0.760, 0.724, 5.0%, 0.732, 0.696; Asn, His, Ala, Cit, Lys, Ile, 0.760, 0.694, 3.3%, 0.690, 0.702; Asn, His, Cit, Met, Lys, Ile, 0.760, 0.693, 2.8%, 0.682, 0.651; Asn, His, Cit, Orn, Lys, Ile, 0.760, 0.684, 5.0%, 0.678, 0.659; Asn, His, Cit, Tyr, Val, Ile, 0.760, 0.727, 3.5%, 0.742, 0.734; Asn, His, Tyr, Met, Ile, Phe, 0.760, 0.730, 2.9%, 0.735, 0.671; Asn, Thr, Arg, Orn, Lys, Ile, 0.760, 0.666, 2.8%, 0.661, 0.671; Cit, Arg, Tyr, Met, Lys, Ile, 0.760, 0.720, 4.2%, 0.718, 0.740; Gln, Arg, Val, Orn, Lys, Ile, 0.760, 0.673, 0.9%, 0.675, 0.728; Gln, Cit, Tyr, Orn, Ile, Leu, 0.760, 0.715, 3.1%, 0.728, 0.746; Gln, His, Ala, Val, Met, Ile, 0.760, 0.707, 0.6%, 0.727, 0.718; Gln, His, Arg, Tyr, Lys, Ile, 0.760, 0.726, 2.6%, 0.742, 0.785; Gln, His, Cit, Ile, Leu, Trp, 0.760, 0.714, 0.9%, 0.730, 0.718; Gln, His, Cit, Orn, Lys, Ile, 0.760, 0.688, 1.7%, 0.689, 0.726; Gln, His, Thr, Ala, Cit, Ile, 0.760, 0.710, 0.9%, 0.735, 0.744; Gln, His, Tyr, Lys, Leu, Trp, 0.760, 0.730, 3.5%, 0.716, 0.724; Gln, His, Val, Lys, Ile, Phe, 0.760, 0.692, 0.7%, 0.691, 0.692; Gln, His, Val, Met, Ile, Phe, 0.760, 0.707, 0.2%, 0.729, 0.690; Gln, Pro, Tyr, Val, Ile, Phe, 0.760, 0.733, 5.7%, 0.736, 0.698; Gln, Thr, Tyr, Ile, Phe, Trp, 0.760, 0.730, 7.0%, 0.741, 0.706; Gly, Gln, Ala, Cit, Tyr, Ile, 0.760, 0.727, 4.0%, 0.733, 0.753; Gly, Gln, Arg, Tyr, Leu, Phe, 0.760, 0.723, 2.0%, 0.718, 0.680; Gly, Gln, Cit, Tyr, Met, Ile, 0.760, 0.724, 5.1%, 0.723, 0.734; Gly, Gln, His, Ile, Leu, Phe, 0.760, 0.701, 0.0%, 0.718, 0.669; Gly, Gln, His, Ile, Phe, Trp, 0.760, 0.703, 0.2%, 0.723, 0.677; Gly, Gln, Tyr, Met, Ile, Trp, 0.760, 0.730, 6.6%, 0.725, 0.720; His, Arg, Orn, Lys, Ile, Phe, 0.760, 0.671, 0.4%, 0.656, 0.645; His, Thr, Arg, Tyr, Ile, Phe, 0.760, 0.728, 3.1%, 0.744, 0.706; Ser, Asn, Arg, Lys, Ile, Trp, 0.760, 0.656, 3.1%, 0.643, 0.677; Ser, Asn, Gln, Arg, Lys, Ile, 0.760, 0.663, 2.4%, 0.653, 0.690; Ser, Asn, Gln, His, Val, Ile, 0.760, 0.692, 0.4%, 0.718, 0.740; Ser, Asn, Gly, Gln, Orn, Leu, 0.760, 0.671, 0.2%, 0.650, 0.596; Ser, Asn, Thr, Arg, Lys, Ile, 0.760, 0.655, 3.1%, 0.642, 0.679; Ser, Gln, Arg, Orn, Lys, Ile, 0.760, 0.666, 0.2%, 0.657, 0.720; Ser, Gln, His, Thr, Tyr, Ile, 0.760, 0.725, 3.5%, 0.748, 0.775; Ser, Gln, Thr, Arg, Lys, Ile, 0.760, 0.668, 0.4%, 0.659, 0.720; Ser, Gln, Tyr, Orn, Leu, Trp, 0.760, 0.722, 4.4%, 0.712, 0.714; Ser, Gly, Gln, Tyr, Ile, Leu, 0.760, 0.720, 3.3%, 0.718, 0.722; Arg, Tyr, Lys, Ile, Leu, Trp, 0.759, 0.716, 6.4%, 0.703, 0.722; Arg, Tyr, Orn, Lys, Ile, Trp, 0.759, 0.714, 7.4%, 0.703, 0.728; Asn, Ala, Cit, Lys, Ile, Leu, 0.759, 0.681, 1.5%, 0.672, 0.692; Asn, Arg, Pro, Tyr, Orn, Lys, 0.759, 0.693, 8.3%, 0.688, 0.748; Asn, Gln, Ala, Tyr, Lys, Leu, 0.759, 0.723, 2.9%, 0.713, 0.714; Asn, Gln, His, Arg, Met, Ile, 0.759, 0.713, 0.9%, 0.736, 0.718; Asn, Gln, His, Lys, Ile, Trp, 0.759, 0.699, 2.2%, 0.691, 0.677; Asn, Gln, His, Lys, Leu, Phe, 0.759, 0.691, 0.0%, 0.673, 0.643; Asn, Gln, His, Met, Ile, Leu, 0.759, 0.713, 0.9%, 0.735, 0.714; Asn, Gln, Lys, Ile, Phe, Trp, 0.759, 0.680, 1.7%, 0.660, 0.651; Asn, Gln, Orn, Lys, Leu, Phe, 0.759, 0.670, 0.2%, 0.637, 0.594; Asn, Gly, Gln, His, Arg, Ile, 0.759, 0.706, 1.1%, 0.729, 0.702; Asn, Gly, Gln, Lys, Ile, Phe, 0.759, 0.674, 1.5%, 0.649, 0.635; Asn, Gly, His, Lys, Ile, Phe, 0.759, 0.688, 1.7%, 0.671, 0.633; Asn, Gly, Thr, Arg, Lys, Ile, 0.759, 0.674, 2.0%, 0.659, 0.667; Asn, Gly, Tyr, Met, Lys, Ile, 0.759, 0.713, 9.6%, 0.682, 0.680; Asn, His, Arg, Orn, Ile, Phe, 0.759, 0.685, 0.6%, 0.694, 0.633; Asn, His, Arg, Pro, Tyr, Ile, 0.759, 0.735, 3.9%, 0.748, 0.722; Asn, His, Cit, Val, Lys, Ile, 0.759, 0.690, 4.4%, 0.685, 0.684; Asn, Thr, Cit, Pro, Lys, Ile, 0.759, 0.682, 2.2%, 0.666, 0.690; Asn, Tyr, Val, Met, Lys, Ile, 0.759, 0.717, 9.4%, 0.698, 0.692; Gln, Ala, Pro, Tyr, Ile, Phe, 0.759, 0.726, 4.6%, 0.738, 0.710; Gln, Arg, Orn, Lys, Ile, Leu, 0.759, 0.681, 1.1%, 0.677, 0.712; Gln, Arg, Tyr, Ile, Leu, Trp, 0.759, 0.735, 5.5%, 0.734, 0.730; Gln, His, Ala, Arg, Ile, Trp, 0.759, 0.710, 1.7%, 0.732, 0.720; Gln, His, Ala, Cit, Val, Ile, 0.759, 0.710, 0.7%, 0.737, 0.740; Gln, His, Ala, Ile, Phe, Trp, 0.759, 0.701, 0.4%, 0.716, 0.684; Gln, His, Ala, Met, Ile, Trp, 0.759, 0.709, 1.1%, 0.727, 0.714; Gln, His, Ala, Pro, Met, Ile, 0.759, 0.708, 1.1%, 0.728, 0.718; Gln, His, Arg, Val, Lys, Ile, 0.759, 0.694, 0.7%, 0.711, 0.753; Gln, His, Cit, Arg, Ile, Leu, 0.759, 0.712, 0.7%, 0.737, 0.734; Gln, His, Cit, Arg, Tyr, Ile, 0.759, 0.734, 2.4%, 0.761, 0.791; Gln, His, Cit, Val, Ile, Trp, 0.759, 0.714, 0.9%, 0.732, 0.720; Gln, His, Pro, Tyr, Ile, Leu, 0.759, 0.730, 2.4%, 0.748, 0.771; Gln, His, Thr, Ala, Met, Ile, 0.759, 0.705, 0.7%, 0.724, 0.720; Gln, His, Thr, Cit, Ile, Leu, 0.759, 0.711, 0.7%, 0.737, 0.746; Gln, His, Thr, Tyr, Ile, Leu, 0.759, 0.733, 3.7%, 0.750, 0.765; Gln, His, Tyr, Met, Lys, Ile, 0.759, 0.734, 4.0%, 0.738, 0.753; Gln, Thr, Pro, Tyr, Ile, Phe, 0.759, 0.730, 6.1%, 0.744, 0.710; Gln, Thr, Tyr, Lys, Leu, Phe, 0.759, 0.730, 2.0%, 0.725, 0.706; Gln, Tyr, Met, Lys, Ile, Trp, 0.759, 0.726, 6.2%, 0.715, 0.746; Gln, Tyr, Met, Orn, Ile, Phe, 0.759, 0.732, 5.7%, 0.741, 0.702; Gly, Gln, Ala, Tyr, Ile, Trp, 0.759, 0.731, 7.4%, 0.726, 0.738; Gly, Gln, Cit, Tyr, Orn, Ile, 0.759, 0.708, 3.1%, 0.714, 0.740; Gly, Gln, His, Ala, Tyr, Ile, 0.759, 0.731, 3.1%, 0.739, 0.757; Gly, Gln, Pro, Tyr, Ile, Trp, 0.759, 0.728, 6.2%, 0.725, 0.746; Gly, Gln, Tyr, Ile, Leu, Trp, 0.759, 0.728, 5.1%, 0.711, 0.706; Gly, Gln, Tyr, Met, Lys, Leu, 0.759, 0.724, 2.4%, 0.704, 0.694; Gly, Gln, Tyr, Val, Lys, Ile, 0.759, 0.712, 5.0%, 0.703, 0.746; Gly, Gln, Tyr, Val, Lys, Trp, 0.759, 0.730, 6.6%, 0.703, 0.718; Gly, Gln, Tyr, Val, Met, Ile, 0.759, 0.730, 5.3%, 0.722, 0.714; His, Cit, Tyr, Ile, Phe, Trp, 0.759, 0.717, 3.5%, 0.719, 0.700; His, Pro, Tyr, Met, Ile, Phe, 0.759, 0.725, 2.4%, 0.724, 0.673; His,

 Thr, Tyr, Ile, Phe, Trp, 0.759, 0.726, 3.7%, 0.728, 0.671; His, Tyr, Met, Lys, Ile, Trp, 0.759, 0.723, 6.6%, 0.712, 0.702; Ser, Asn, His, Tyr, Met, Ile, 0.759, 0.729, 3.7%, 0.736, 0.708; Ser, Asn, Tyr, Met, Lys, Ile, 0.759, 0.712, 8.1%, 0.688, 0.698; Ser, Gln, Arg, Tyr, Ile, Phe, 0.759, 0.717, 4.4%, 0.733, 0.724; Ser, His, Arg, Tyr, Ile, Phe, 0.759, 0.720, 3.5%, 0.730, 0.696; Arg, Pro, Tyr, Orn, Lys, Ile, 0.759, 0.707, 5.0%, 0.707, 0.742; Arg, Tyr, Orn, Lys, Ile, Leu, 0.759, 0.710, 3.7%, 0.708, 0.734; Asn, Arg, Tyr, Met, Lys, Leu, 0.759, 0.729, 3.5%, 0.717, 0.686; Asn, Gln, Ala, Cit, Lys, Ile, 0.759, 0.684, 1.5%, 0.676, 0.704; Asn, Gln, Ala, Tyr, Ile, Phe, 0.759, 0.726, 6.1%, 0.738, 0.708; Asn, Gln, Cit, Lys, Leu, Phe, 0.759, 0.677, 0.0%, 0.647, 0.607; Asn, Gln, His, Orn, Ile, Trp, 0.759, 0.698, 2.2%, 0.718, 0.688; Asn, Gln, His, Orn, Lys, Ile, 0.759, 0.690, 2.6%, 0.682, 0.671; Asn, Gln, His, Pro, Ile, Trp, 0.759, 0.709, 1.8%, 0.733, 0.708; Asn, Gln, His, Thr, Pro, Ile, 0.759, 0.710, 1.8%, 0.733, 0.722; Asn, Gln, His, Tyr, Lys, Leu, 0.759, 0.731, 3.5%, 0.725, 0.726; Asn, Gln, His, Tyr, Val, Leu, 0.759, 0.735, 1.1%, 0.739, 0.724; Asn, Gln, Val, Lys, Leu, Phe, 0.759, 0.677, 0.0%, 0.647, 0.607; Asn, Gly, Arg, Lys, Ile, Trp, 0.759, 0.673, 2.2%, 0.657, 0.663; Asn, Gly, Cit, Arg, Lys, Ile, 0.759, 0.674, 2.2%, 0.662, 0.667; Asn, Gly, Cit, Arg, Tyr, Ile, 0.759, 0.727, 5.9%, 0.727, 0.718; Asn, Gly, Tyr, Lys, Leu, Phe, 0.759, 0.714, 2.2%, 0.686, 0.617; Asn, His, Cit, Lys, Ile, Leu, 0.759, 0.693, 3.9%, 0.690, 0.684; Asn, Pro, Tyr, Lys, Leu, Phe, 0.759, 0.718, 2.0%, 0.696, 0.635; Asn, Thr, Cit, Tyr, Leu, Phe, 0.759, 0.733, 2.8%, 0.731, 0.667; Asn, Thr, Tyr, Lys, Ile, Phe, 0.759, 0.721, 7.2%, 0.700, 0.673; Asn, Tyr, Met, Lys, Ile, Trp, 0.759, 0.716, 8.1%, 0.695, 0.696; Cit, Tyr, Lys, Ile, Leu, Trp, 0.759, 0.716, 4.4%, 0.702, 0.716; Cit, Tyr, Met, Lys, Ile, Phe, 0.759, 0.716, 5.3%, 0.708, 0.704; Gln, Ala, Arg, Lys, Ile, Phe, 0.759, 0.675, 1.1%, 0.679, 0.706; Gln, Ala, Tyr, Ile, Leu, Phe, 0.759, 0.724, 2.8%, 0.734, 0.704; Gln, Ala, Tyr, Lys, Leu, Phe, 0.759, 0.721, 2.2%, 0.719, 0.700; Gln, Arg, Tyr, Orn, Lys, Ile, 0.759, 0.718, 4.4%, 0.728, 0.775; Gln, Arg, Val, Lys, Ile, Leu, 0.759, 0.682, 1.1%, 0.685, 0.734; Gln, Cit, Tyr, Lys, Ile, Trp, 0.759, 0.723, 4.4%, 0.725, 0.783; Gln, His, Ala, Orn, Ile, Phe, 0.759, 0.690, 0.6%, 0.706, 0.679; Gln, His, Ala, Val, Ile, Trp, 0.759, 0.710, 1.8%, 0.728, 0.718; Gln, His, Cit, Arg, Met, Ile, 0.759, 0.710, 0.7%, 0.731, 0.724; Gln, His, Cit, Val, Ile, Leu, 0.759, 0.712, 0.7%, 0.738, 0.736; Gln, His, Cit, Val, Met, Ile, 0.759, 0.711, 0.7%, 0.735, 0.724; Gln, His, Met, Ile, Leu, Phe, 0.759, 0.706, 0.2%, 0.725, 0.684; Gln, His, Orn, Ile, Leu, Phe, 0.759, 0.694, 0.2%, 0.711, 0.669; Gln, His, Orn, Ile, Phe, Trp, 0.759, 0.695, 0.6%, 0.713, 0.675; Gln, His, Pro, Tyr, Val, Ile, 0.759, 0.730, 2.6%, 0.750, 0.777; Gln, His, Thr, Tyr, Lys, Ile, 0.759, 0.726, 5.1%, 0.734, 0.765; Gln, His, Thr, Tyr, Val, Ile, 0.759, 0.733, 3.7%, 0.752, 0.767; Gln, His, Tyr, Met, Lys, Leu, 0.759, 0.734, 1.7%, 0.730, 0.724; Gln, His, Tyr, Val, Orn, Trp, 0.759, 0.728, 3.9%, 0.722, 0.736; Gln, His, Val, Orn, Ile, Phe, 0.759, 0.693, 0.4%, 0.713, 0.684; Gln, Pro, Tyr, Orn, Ile, Phe, 0.759, 0.731, 5.5%, 0.743, 0.706; Gln, Thr, Tyr, Leu, Phe, Trp, 0.759, 0.735, 2.8%, 0.733, 0.684; Gln, Thr, Tyr, Orn, Ile, Phe, 0.759, 0.730, 5.9%, 0.741, 0.704; Gln, Tyr, Val, Met, Lys, Ile, 0.759, 0.723, 5.1%, 0.718, 0.748; Gln, Tyr, Val, Orn, Ile, Phe, 0.759, 0.734, 5.7%, 0.736, 0.702; Gly, Gln, Ala, Tyr, Lys, Ile, 0.759, 0.715, 5.7%, 0.704, 0.746; Gly, Gln, Arg, Lys, Ile, Leu, 0.759, 0.678, 1.1%, 0.668, 0.702; Gly, Gln, Cit, Tyr, Val, Ile, 0.759, 0.722, 4.0%, 0.723, 0.732; Gly, Gln, His, Ala, Tyr, Leu, 0.759, 0.724, 2.2%, 0.721, 0.732; Gly, Gln, Pro, Tyr, Ile, Leu, 0.759, 0.721, 3.1%, 0.718, 0.728; Gly, Gln, Pro, Tyr, Lys, Ile, 0.759, 0.714, 4.2%, 0.705, 0.748; Gly, Gln, Thr, Tyr, Lys, Ile, 0.759, 0.715, 5.3%, 0.702, 0.734; Gly, Gln, Tyr, Val, Leu, Trp, 0.759, 0.728, 5.1%, 0.707, 0.698; Gly, His, Tyr, Met, Ile, Trp, 0.759, 0.724, 4.2%, 0.718, 0.688; His, Ala, Arg, Tyr, Ile, Phe, 0.759, 0.716, 2.9%, 0.730, 0.702; His, Ala, Cit, Tyr, Ile, Phe, 0.759, 0.712, 2.4%, 0.721, 0.718; His, Arg, Tyr, Ile, Phe, Trp, 0.759, 0.721, 4.2%, 0.731, 0.677; His, Cit, Arg, Tyr, Met, Ile, 0.759, 0.730, 3.9%, 0.740, 0.734; His, Pro, Tyr, Met, Ile, Trp, 0.759, 0.728, 4.4%, 0.728, 0.702; His, Thr, Ala, Tyr, Ile, Phe, 0.759, 0.722, 3.3%, 0.733, 0.688; His, Tyr, Met, Lys, Ile, Leu, 0.759, 0.722, 5.5%, 0.706, 0.704; His, Tyr, Val, Met, Lys, Ile, 0.759, 0.725, 7.5%, 0.710, 0.710; Ser, Arg, Lys, Ile, Phe, Trp, 0.759, 0.656, 1.3%, 0.637, 0.665; Ser, Asn, Cit, Tyr, Orn, Ile, 0.759, 0.713, 4.6%, 0.723, 0.728; Ser, Asn, Gln, His, Arg, Ile, 0.759, 0.695, 0.2%, 0.717, 0.724; Ser, Asn, Gly, Arg, Lys, Ile, 0.759, 0.657, 2.8%, 0.645, 0.677; Ser, Asn, His, Arg, Tyr, Ile, 0.759, 0.720, 3.5%, 0.735, 0.716; Ser, Asn, His, Cit, Tyr, Ile, 0.759, 0.722, 3.9%, 0.738, 0.744; Ser, Gln, His, Arg, Ile, Phe, 0.759, 0.690, 0.4%, 0.710, 0.692; Ser, Gln, His, Cit, Tyr, Ile, 0.759, 0.726, 2.0%, 0.751, 0.797; Ser, Gln, Thr, Tyr, Lys, Ile, 0.759, 0.707, 6.2%, 0.704, 0.763; Ser, Gln, Tyr, Lys, Ile, Leu, 0.759, 0.711, 3.9%, 0.706, 0.757; Ser, Gly, Gln, Tyr, Ile, Trp, 0.759, 0.712, 6.6%, 0.710, 0.750; Ser, Gly, Gln, Tyr, Leu, Trp, 0.759, 0.730, 4.6%, 0.713, 0.694; Ser, His, Thr, Tyr, Ile, Phe, 0.759, 0.717, 2.6%, 0.724, 0.680; Thr, Tyr, Orn, Lys, Ile, Phe, 0.759, 0.724, 5.1%, 0.714, 0.698; Asn, Ala, Cit, Tyr, Ile, Phe, 0.758, 0.724, 4.6%, 0.734, 0.694; Asn, Ala, Tyr, Met, Lys, Ile, 0.758, 0.717, 8.3%, 0.696, 0.694; Asn, Arg, Tyr, Orn, Lys, Leu, 0.758, 0.711, 3.5%, 0.705, 0.692; Asn, Cit, Lys, Ile, Leu, Phe, 0.758, 0.685, 1.5%, 0.667, 0.647; Asn, Cit, Lys, Ile, Leu, Trp, 0.758, 0.682, 1.5%, 0.670, 0.673; Asn, Cit, Pro, Lys, Ile, Phe, 0.758, 0.678, 2.6%, 0.661, 0.667; Asn, Cit, Pro, Met, Lys, Ile, 0.758, 0.680, 1.8%, 0.665, 0.686; Asn, Cit, Pro, Tyr, Lys, Ile, 0.758, 0.708, 5.5%, 0.705, 0.728; Asn, Cit, Tyr, Orn, Ile, Phe, 0.758, 0.717, 5.3%, 0.724, 0.690; Asn, Gln, Cit, Arg, Lys, Ile, 0.758, 0.680, 2.0%, 0.675, 0.704; Asn, Gln, Cit, Tyr, Ile, Phe, 0.758, 0.729, 4.0%, 0.745, 0.714; Asn, Gln, His, Met, Ile, Trp, 0.758, 0.710, 1.5%, 0.730, 0.710; Asn, Gln, His, Thr, Arg, Ile, 0.758, 0.710, 1.5%, 0.737, 0.724; Asn, Gln, His, Thr, Lys, Ile, 0.758, 0.698, 2.6%, 0.693, 0.682; Asn, Gln, Tyr, Met, Lys, Leu, 0.758, 0.729, 2.6%, 0.719, 0.694; Asn, Gly, Cit, Tyr, Ile, Trp, 0.758, 0.724, 7.4%, 0.723, 0.716; Asn, Gly, Gln, Ala, Lys, Ile, 0.758, 0.675, 2.0%, 0.650, 0.669; Asn, Gly, Gln, Arg, Tyr, Leu, 0.758, 0.724, 3.5%, 0.715, 0.680; Asn, Gly, Gln, His, Tyr, Val, 0.758, 0.736, 4.4%, 0.729, 0.716; Asn, Gly, Gln, Tyr, Ile, Phe, 0.758, 0.721, 5.7%, 0.722, 0.700; Asn, Gly, Gln, Tyr, Val, Lys, 0.758, 0.728, 6.8%, 0.707, 0.706; Asn, Gly, Gln, Val, Lys, Leu, 0.758, 0.677, 0.2%, 0.640, 0.596; Asn, His, Cit, Tyr, Ile, Trp, 0.758, 0.730, 3.9%, 0.744, 0.734; Asn, His, Tyr, Ile, Phe, Trp, 0.758, 0.721, 2.8%, 0.727, 0.669; Asn, His, Tyr, Lys, Ile, Phe, 0.758, 0.718, 4.4%, 0.710, 0.675; Asn, Thr, Cit, Lys, Ile, Leu, 0.758, 0.682, 1.5%, 0.671, 0.675; Gln, Ala, Tyr, Lys, Ile, Trp, 0.758, 0.724, 7.7%, 0.714, 0.746; Gln, Arg, Tyr, Val, Ile, Phe, 0.758, 0.735, 3.5%, 0.744, 0.710; Gln, Cit, Ile, Leu, Phe, Trp, 0.758, 0.695, 0.2%, 0.703, 0.655; Gln, Cit, Tyr, Orn, Leu, Phe, 0.758, 0.712, 1.8%, 0.719, 0.684; Gln, His, Ala, Cit, Met, Ile, 0.758, 0.709, 0.9%, 0.732, 0.732; Gln, His, Ala, Ile, Leu, Phe, 0.758, 0.696, 0.2%, 0.710, 0.669; Gln, His, Ala, Val, Ile, Phe, 0.758, 0.700, 0.4%, 0.717, 0.686; Gln, His, Arg, Met, Ile, Phe, 0.758, 0.708, 0.0%, 0.736, 0.696; Gln, His, Cit, Tyr, Met, Ile, 0.758, 0.741, 3.3%, 0.762, 0.763; Gln, His, Orn, Lys, Ile, Phe, 0.758, 0.693, 0.6%, 0.687, 0.657; Gln, His, Thr, Cit, Arg, Ile, 0.758, 0.710, 0.7%, 0.734, 0.746; Gln, His, Thr, Cit, Ile, Trp, 0.758, 0.710, 0.9%, 0.731, 0.732; Gln, His, Thr, Pro, Tyr, Ile, 0.758, 0.735, 3.1%, 0.754, 0.769; Gln, Thr, Arg, Val, Lys, Ile, 0.758, 0.682, 1.1%, 0.687, 0.738; Gly, Gln, Ala, Tyr, Val, Ile, 0.758, 0.730, 6.6%, 0.725, 0.728; Gly, Gln, His, Ala, Met, Ile, 0.758, 0.703, 0.9%, 0.716, 0.706; Gly, Gln, His, Thr, Tyr, Ile, 0.758, 0.733, 4.4%, 0.751, 0.759; Gly, Gln, His, Tyr, Lys, Ile, 0.758, 0.723, 3.9%, 0.725, 0.753; Gly, Gln, His, Tyr, Orn, Leu, 0.758, 0.722, 2.4%, 0.720, 0.730; Gly, Gln, Thr, Tyr, Ile, Trp, 0.758, 0.727, 7.9%, 0.727, 0.730; Gly, Gln, Thr, Tyr, Leu, Trp, 0.758, 0.727, 7.2%, 0.708, 0.688; His, Ala, Arg, Tyr, Lys, Ile, 0.758, 0.711, 2.8%, 0.711, 0.742; His, Ala, Tyr, Ile, Phe, Trp, 0.758, 0.708, 4.8%, 0.702, 0.673; His, Arg, Pro, Tyr, Lys, Ile, 0.758, 0.710, 3.7%, 0.709, 0.746; His, Arg, Tyr, Val, Lys, Ile, 0.758, 0.713, 2.9%, 0.712, 0.742; His, Cit, Arg, Tyr, Lys, Ile, 0.758, 0.713, 2.6%, 0.716, 0.751; His, Cit, Tyr, Ile, Leu, Phe, 0.758, 0.714, 2.0%, 0.718, 0.692; Ser, Asn, Cit, Arg, Lys, Ile, 0.758, 0.659, 2.6%, 0.645, 0.679; Ser, Asn, Gln, His, Cit, Ile, 0.758, 0.696, 0.2%, 0.713, 0.722; Ser, Asn, Gln, His, Lys, Ile, 0.758, 0.682, 2.0%, 0.673, 0.686; Ser, Asn, Gln, His, Tyr, Leu, 0.758, 0.733, 1.1%, 0.738, 0.722; Ser, Asn, Gly, Gln, Lys, Leu, 0.758, 0.672, 0.2%, 0.637, 0.604; Ser, Gln, Arg, Met, Lys, Ile, 0.758, 0.669, 0.2%, 0.660, 0.722; Ser, Gln, Cit, Tyr, Ile, Phe, 0.758, 0.718, 3.3%, 0.735, 0.730; Ser, Gln, His, Tyr, Leu, Trp, 0.758, 0.731, 3.5%, 0.725, 0.716; Ser, Gln, Tyr, Ile, Leu, Trp, 0.758, 0.717, 6.2%, 0.709, 0.726; Ser, Gln, Tyr, Met, Leu, Phe, 0.758, 0.733, 1.8%, 0.733, 0.675; Ser, His, Tyr, Met, Ile, Trp, 0.758, 0.722, 5.7%, 0.720, 0.702; Thr, Arg, Tyr, Ile, Leu, Phe, 0.758, 0.726, 2.9%, 0.730, 0.686; Tyr, Met, Lys, Ile, Leu, Phe, 0.758, 0.720, 4.0%, 0.705, 0.677; Tyr, Val, Met, Lys, Ile, Phe, 0.758, 0.720, 6.6%, 0.703, 0.688; Arg, Tyr, Met, Ile, Leu, Phe, 0.757, 0.725, 2.9%, 0.724, 0.675; Asn, Arg, Tyr, Lys, Leu, Trp, 0.757, 0.722, 4.0%, 0.709, 0.692; Asn, Gln, Cit, Ile, Leu, Phe, 0.757, 0.698, 0.0%, 0.706, 0.645; Asn, Gln, His, Cit, Tyr, Leu, 0.757, 0.734, 1.3%, 0.744, 0.734; Asn, Gln, His, Met, Orn, Ile, 0.757, 0.699, 1.8%, 0.722, 0.698; Asn, Gln, His, Val, Ile, Trp, 0.757, 0.708, 1.5%, 0.733, 0.712; Asn, Gln, Thr, Tyr, Ile, Leu, 0.757, 0.731, 4.2%, 0.733, 0.704; Asn,G

ly, Arg, Tyr, Leu, Phe, 0.757, 0.720, 1.8%, 0.708, 0.635; Asn, Gly, Cit, Met, Lys, Ile, 0.757, 0.678, 1.7%, 0.662, 0.671; Asn, Gly, Gln, Cit, Orn, Ile, 0.757, 0.681, 1.8%, 0.682, 0.667; Asn, Gly, Gln, His, Met, Ile, 0.757, 0.704, 1.3%, 0.725, 0.692; Asn, Gly, Gln, Thr, Lys, Ile, 0.757, 0.676, 1.8%, 0.649, 0.661; Asn, Gly, Gln, Tyr, Orn, Leu, 0.757, 0.725, 3.7%, 0.715, 0.673; Asn, Gly, Thr, Tyr, Leu, Phe, 0.757, 0.723, 4.0%, 0.708, 0.629; Asn, Thr, Arg, Lys, Ile, Trp, 0.757, 0.675, 2.2%, 0.670, 0.686; Cit, Pro, Tyr, Lys, Ile, Trp, 0.757, 0.713, 5.7%, 0.702, 0.742; Gln, Ala, Tyr, Orn, Ile, Phe, 0.757, 0.729, 5.0%, 0.739, 0.706; Gln, Arg, Tyr, Ile, Phe, Trp, 0.757, 0.729, 4.8%, 0.741, 0.716; Gln, Arg, Tyr, Lys, Leu, Trp, 0.757, 0.730, 3.3%, 0.720, 0.736; Gln, Cit, Pro, Tyr, Ile, Phe, 0.757, 0.728, 3.9%, 0.747, 0.726; Gln, His, Ala, Pro, Ile, Phe, 0.757, 0.699, 0.4%, 0.715, 0.680; Gln, His, Arg, Met, Lys, Ile, 0.757, 0.696, 0.6%, 0.702, 0.704; Gln, His, Val, Met, Orn, Ile, 0.757, 0.697, 0.9%, 0.717, 0.700; Gln, Thr, Cit, Tyr, Ile, Phe, 0.757, 0.730, 3.5%, 0.750, 0.730; Gln, Tyr, Orn, Lys, Leu, Phe, 0.757, 0.721, 2.2%, 0.716, 0.696; Gly, Gln, Ala, Arg, Lys, Ile, 0.757, 0.679, 0.7%, 0.674, 0.706; Gly, Gln, Arg, Tyr, Ile, Leu, 0.757, 0.724, 3.3%, 0.725, 0.718; Gly, Gln, Cit, Pro, Tyr, Ile, 0.757, 0.720, 3.5%, 0.725, 0.734; Gly, Gln, His, Ala, Ile, Phe, 0.757, 0.697, 0.2%, 0.713, 0.677; Gly, Gln, His, Thr, Cit, Ile, 0.757, 0.703, 1.3%, 0.717, 0.724; Gly, Gln, Orn, Lys, Ile, Phe, 0.757, 0.674, 0.7%, 0.645, 0.655; His, Cit, Tyr, Orn, Ile, Phe, 0.757, 0.707, 2.6%, 0.712, 0.708; Ser, Asn, Gly, Gln, Tyr, Ile, 0.757, 0.716, 5.7%, 0.717, 0.726; Ser, Gln, His, Orn, Ile, Phe, 0.757, 0.683, 0.4%, 0.703, 0.677; Ser, Gly, Gln, Thr, Tyr, Ile, 0.757, 0.713, 7.2%, 0.717, 0.738; Ser, His, Cit, Tyr, Ile, Phe, 0.757, 0.717, 2.2%, 0.723, 0.710; Thr, Cit, Tyr, Lys, Ile, Phe, 0.757, 0.719, 4.8%, 0.719, 0.716; Ala, Arg, Tyr, Lys, Ile, Trp, 0.757, 0.714, 7.4%, 0.702, 0.726; Arg, Tyr, Lys, Leu, Phe, Trp, 0.757, 0.722, 2.4%, 0.705, 0.659; Asn, Arg, Lys, Ile, Leu, Trp, 0.757, 0.675, 2.0%, 0.669, 0.680; Asn, Arg, Pro, Lys, Ile, Phe, 0.757, 0.670, 3.1%, 0.658, 0.645; Asn, Gln, His, Ala, Lys, Ile, 0.757, 0.695, 2.4%, 0.691, 0.690; Asn, Gln, His, Arg, Ile, Trp, 0.757, 0.710, 1.3%, 0.733, 0.712; Asn, Gln, His, Ile, Leu, Trp, 0.757, 0.709, 1.5%, 0.730, 0.706; Asn, Gly, Gln, His, Pro, Ile, 0.757, 0.703, 1.3%, 0.725, 0.700; Asn, Gly, Gln, Met, Lys, Ile, 0.757, 0.677, 2.4%, 0.650, 0.669; Asn, Gly, Pro, Tyr, Ile, Leu, 0.757, 0.722, 5.3%, 0.706, 0.667; Asn, His, Cit, Lys, Ile, Trp, 0.757, 0.692, 3.7%, 0.687, 0.667; Asn, His, Thr, Tyr, Leu, Phe, 0.757, 0.733, 2.6%, 0.735, 0.655; Asn, Tyr, Lys, Leu, Phe, Trp, 0.757, 0.721, 1.8%, 0.699, 0.643; Asn, Tyr, Val, Lys, Leu, Phe, 0.757, 0.720, 1.8%, 0.700, 0.647; Gln, Arg, Val, Lys, Ile, Trp, 0.757, 0.683, 1.1%, 0.681, 0.740; Gln, Arg, Val, Met, Lys, Ile, 0.757, 0.684, 1.3%, 0.688, 0.738; Gln, Cit, Pro, Tyr, Leu, Phe, 0.757, 0.726, 1.8%, 0.732, 0.690; Gln, His, Arg, Tyr, Leu, Phe, 0.757, 0.734, 1.3%, 0.744, 0.714; Gln, His, Pro, Ile, Phe, Trp, 0.757, 0.704, 0.4%, 0.724, 0.677; Gln, His, Tyr, Orn, Leu, Trp, 0.757, 0.726, 3.5%, 0.722, 0.712; Gln, His, Tyr, Val, Leu, Phe, 0.757, 0.734, 1.5%, 0.741, 0.708; Gln, His, Tyr, Val, Lys, Ile, 0.757, 0.725, 3.9%, 0.735, 0.775; Gln, His, Tyr, Val, Met, Orn, 0.757, 0.729, 2.8%, 0.728, 0.720; Gln, His, Tyr, Val, Orn, Phe, 0.757, 0.729, 2.2%, 0.731, 0.704; Gln, His, Val, Met, Ile, Leu, 0.757, 0.711, 0.7%, 0.730, 0.720; Gln, Thr, Arg, Orn, Lys, Ile, 0.757, 0.682, 0.7%, 0.680, 0.712; Gln, Thr, Tyr, Met, Lys, Ile, 0.757, 0.725, 5.7%, 0.720, 0.750; Gln, Tyr, Val, Lys, Ile, Trp, 0.757, 0.720, 7.2%, 0.713, 0.751; Gln, Tyr, Val, Orn, Leu, Phe, 0.757, 0.720, 2.0%, 0.721, 0.677; Gly, Gln, Arg, Val, Lys, Ile, 0.757, 0.676, 1.3%, 0.668, 0.716; Gly, Gln, His, Cit, Ile, Trp, 0.757, 0.708, 1.5%, 0.718, 0.700; Gly, Gln, His, Lys, Ile, Phe, 0.757, 0.694, 0.4%, 0.687, 0.659; Gly, Gln, His, Tyr, Val, Met, 0.757, 0.736, 2.9%, 0.728, 0.710; Ser, Asn, Arg, Met, Lys, Ile, 0.757, 0.659, 2.6%, 0.648, 0.684; Ser, Asn, Gln, His, Thr, Ile, 0.757, 0.694, 0.4%, 0.714, 0.720; Ser, Asn, Gln, Tyr, Leu, Trp, 0.757, 0.726, 4.2%, 0.718, 0.700; Ser, Asn, Gly, Gln, His, Ile, 0.757, 0.693, 0.7%, 0.713, 0.710; Ser, Asn, Gly, Gln, Tyr, Leu, 0.757, 0.729, 3.7%, 0.719, 0.677; Ser, Gly, Gln, His, Ile, Phe, 0.757, 0.692, 0.4%, 0.709, 0.682; Ser, Tyr, Met, Lys, Ile, Phe, 0.757, 0.716, 7.5%, 0.697, 0.682; Tyr, Met, Orn, Lys, Ile, Phe, 0.757, 0.728, 5.5%, 0.711, 0.696; Ala, Arg, Pro, Tyr, Lys, Ile, 0.757, 0.710, 4.8%, 0.706, 0.742; Arg, Orn, Lys, Ile, Leu, Phe, 0.757, 0.668, 0.9%, 0.654, 0.651; Arg, Pro, Tyr, Ile, Leu, Phe, 0.757, 0.719, 2.6%, 0.721, 0.679; Arg, Pro, Tyr, Lys, Ile, Trp, 0.757, 0.714, 7.4%, 0.702, 0.726; Arg, Tyr, Orn, Ile, Leu, Phe, 0.757, 0.718, 2.9%, 0.722, 0.684; Asn, Ala, Cit, Pro, Lys, Ile, 0.757, 0.677, 2.0%, 0.665, 0.692; Asn, Arg, Val, Lys, Ile, Leu, 0.757, 0.671, 2.2%, 0.664, 0.684; Asn, Cit, Arg, Lys, Ile, Trp, 0.757, 0.675, 2.0%, 0.670, 0.692; Asn, Cit, Arg, Val, Lys, Ile, 0.757, 0.672, 2.4%, 0.666, 0.688; Asn, Cit, Tyr, Lys, Leu, Phe, 0.757, 0.722, 2.0%, 0.705, 0.653; Asn, Cit, Tyr, Met, Ile, Phe, 0.757, 0.729, 5.1%, 0.733, 0.684; Asn, Gln, Cit, Tyr, Ile, Leu, 0.757, 0.731, 2.8%, 0.742, 0.720; Asn, Gln, Cit, Tyr, Orn, Ile, 0.757, 0.714, 4.8%, 0.729, 0.744; Asn, Gln, His, Arg, Tyr, Val, 0.757, 0.741, 2.2%, 0.745, 0.748; Asn, Gln, His, Met, Lys, Ile, 0.757, 0.698, 2.4%, 0.692, 0.682; Asn, Gln, His, Tyr, Met, Leu, 0.757, 0.739, 2.6%, 0.741, 0.710; Asn, Gln, Thr, Tyr, Lys, Ile, 0.757, 0.725, 8.1%, 0.719, 0.718; Asn, Gln, Val, Ile, Leu, Phe, 0.757, 0.693, 0.0%, 0.698, 0.631; Asn, Gly, Gln, Ala, Tyr, Leu, 0.757, 0.725, 3.7%, 0.714, 0.673; Asn, Gly, Gln, Arg, Tyr, Ile, 0.757, 0.725, 5.5%, 0.726, 0.716; Asn, Gly, Gln, Lys, Leu, Trp, 0.757, 0.676, 0.2%, 0.643, 0.602; Asn, Gly, Gln, Thr, Tyr, Ile, 0.757, 0.724, 7.5%, 0.724, 0.714; Asn, Gly, Gln, Thr, Tyr, Leu, 0.757, 0.729, 5.5%, 0.717, 0.677; Asn, Gly, Gln, Tyr, Met, Ile, 0.757, 0.726, 6.6%, 0.720, 0.706; Asn, Gly, Gln, Tyr, Orn, Ile, 0.757, 0.730, 7.0%, 0.727, 0.718; Asn, His, Orn, Lys, Ile, Phe, 0.757, 0.687, 1.7%, 0.667, 0.625; Asn, His, Thr, Tyr, Ile, Phe, 0.757, 0.729, 3.1%, 0.738, 0.663; Asn, His, Tyr, Met, Ile, Trp, 0.757, 0.734, 5.3%, 0.739, 0.710; Asn, His, Tyr, Orn, Ile, Phe, 0.757, 0.728, 2.6%, 0.735, 0.675; Asn, Pro, Tyr, Met, Lys, Ile, 0.757, 0.715, 8.1%, 0.693, 0.692; Asn, Thr, Cit, Orn, Lys, Ile, 0.757, 0.671, 1.8%, 0.659, 0.663; Asn, Tyr, Lys, Ile, Leu, Phe, 0.757, 0.719, 4.0%, 0.699, 0.657; Asn, Tyr, Met, Ile, Leu, Phe, 0.757, 0.729, 3.7%, 0.718, 0.665; Asn, Tyr, Orn, Ile, Leu, Phe, 0.757, 0.729, 2.2%, 0.720, 0.663; Cit, Tyr, Met, Lys, Ile, Trp, 0.757, 0.715, 4.4%, 0.704, 0.712; Cit, Tyr, Orn, Lys, Ile, Trp, 0.757, 0.704, 5.3%, 0.695, 0.732; Gln, Ala, Tyr, Val, Ile, Phe, 0.757, 0.728, 5.5%, 0.733, 0.702; Gln, Cit, Arg, Lys, Ile, Leu, 0.757, 0.686, 1.3%, 0.687, 0.738; Gln, Cit, Pro, Orn, Ile, Phe, 0.757, 0.682, 1.1%, 0.689, 0.675; Gln, Cit, Tyr, Lys, Leu, Phe, 0.757, 0.725, 1.7%, 0.722, 0.710; Gln, His, Ala, Arg, Met, Ile, 0.757, 0.709, 0.6%, 0.733, 0.718; Gln, His, Ala, Met, Ile, Phe, 0.757, 0.699, 0.4%, 0.715, 0.682; Gln, His, Ala, Tyr, Lys, Leu, 0.757, 0.721, 2.2%, 0.717, 0.742; Gln, His, Arg, Pro, Val, Ile, 0.757, 0.708, 0.9%, 0.735, 0.732; Gln, His, Cit, Arg, Ile, Trp, 0.757, 0.713, 0.9%, 0.728, 0.714; Gln, His, Thr, Ala, Ile, Phe, 0.757, 0.697, 0.4%, 0.713, 0.690; Gln, His, Thr, Cit, Met, Ile, 0.757, 0.710, 0.4%, 0.731, 0.744; Gln, His, Thr, Tyr, Leu, Phe, 0.757, 0.737, 1.7%, 0.744, 0.704; Gln, His, Tyr, Lys, Ile, Leu, 0.757, 0.722, 3.3%, 0.728, 0.769; Gln, His, Tyr, Met, Leu, Trp, 0.757, 0.738, 3.5%, 0.733, 0.710; Gln, Thr, Tyr, Met, Leu, Phe, 0.757, 0.732, 1.7%, 0.733, 0.675; Gln, Tyr, Val, Ile, Leu, Trp, 0.757, 0.734, 5.7%, 0.729, 0.728; Gln, Tyr, Val, Met, Leu, Phe, 0.757, 0.731, 1.7%, 0.731, 0.673; Gly, Arg, Tyr, Ile, Leu, Phe, 0.757, 0.712, 2.8%, 0.709, 0.659; Gly, Cit, Tyr, Lys, Ile, Trp, 0.757, 0.709, 5.3%, 0.690, 0.728; Gly, Gln, Arg, Tyr, Val, Ile, 0.757, 0.728, 5.9%, 0.724, 0.718; Gly, Gln, Cit, Tyr, Leu, Trp, 0.757, 0.727, 4.2%, 0.710, 0.696; Gly, Gln, His, Tyr, Val, Phe, 0.757, 0.732, 3.5%, 0.728, 0.694; Gly, Gln, His, Val, Ile, Phe, 0.757, 0.700, 0.2%, 0.723, 0.680; Gly, Gln, Lys, Ile, Leu, Phe, 0.757, 0.679, 0.6%, 0.651, 0.647; Gly, Gln, Thr, Arg, Lys, Ile, 0.757, 0.680, 0.9%, 0.668, 0.702; Gly, Gln, Thr, Cit, Tyr, Ile, 0.757, 0.721, 4.2%, 0.725, 0.738; His, Cit, Pro, Tyr, Ile, Phe, 0.757, 0.713, 2.6%, 0.720, 0.704; His, Cit, Tyr, Lys, Ile, Phe, 0.757, 0.711, 2.9%, 0.709, 0.726; His, Pro, Tyr, Ile, Phe, Trp, 0.757, 0.714, 4.4%, 0.709, 0.677; Ser, Arg, Tyr, Ile, Leu, Phe, 0.757, 0.719, 2.8%, 0.723, 0.688; Ser, Asn, Ala, Arg, Lys, Ile, 0.757, 0.655, 3.5%, 0.648, 0.696; Ser, Asn, Gln, His, Ala, Ile, 0.757, 0.691, 0.9%, 0.709, 0.716; Ser, Asn, His, Arg, Lys, Ile, 0.757, 0.667, 1.5%, 0.661, 0.673; Ser, Asn, Tyr, Met, Leu, Phe, 0.757, 0.731, 2.4%, 0.720, 0.645; Ser, Gln, His, Ile, Phe, Trp, 0.757, 0.686, 0.7%, 0.703, 0.677; Ser, Gln, His, Tyr, Lys, Ile, 0.757, 0.719, 3.3%, 0.724, 0.771; Ser, Gln, Thr, Tyr, Leu, Phe, 0.757, 0.731, 1.7%, 0.733, 0.680; Ser, His, Tyr, Met, Ile, Phe, 0.757, 0.726, 2.6%, 0.724, 0.673; Ala, Arg, Tyr, Orn, Lys, Ile, 0.756, 0.708, 4.2%, 0.708, 0.740; Ala, Cit, Arg, Tyr, Lys, Ile, 0.756, 0.712, 2.6%, 0.714, 0.746; Arg, Tyr, Val, Ile, Leu, Phe, 0.756, 0.720, 2.8%, 0.722, 0.679; Asn, Arg, Met, Orn, Lys, Ile, 0.756, 0.664, 2.8%, 0.657, 0.673; Asn, Cit, Arg, Lys, Ile, Leu, 0.756, 0.677, 1.8%, 0.672, 0.684; Asn, Cit, Orn, Lys, Ile, Leu, 0.756, 0.673, 1.3%, 0.657, 0.649; Asn, Cit, Pro, Val, Lys, Ile, 0.756, 0.679, 2.0%, 0.665, 0.688; Asn, Cit, Val, Orn, Lys, Ile, 0.756, 0.671, 2.0%, 0.660, 0.665; Asn, Gln, Ala, Tyr, Lys, Ile, 0.756, 0.721, 7.2%, 0.713, 0.716; Asn, Gln, Arg, Tyr, Lys, Leu, 0.756, 0.729, 2.8%, 0.721, 0.714; Asn, Gln, His, Ala, Tyr, Leu, 0.756, 0.730, 1.1%, 0.735, 0.732; Asn, Gln, His, Cit, Lys, Ile, 0.756, 0.700, 2.2%, 0.701, 0.700; Asn, Gln, His, Pro, Tyr, Leu, 0.756, 0.731, 1.1%, 0.739, 0.730; Asn, Gln, His, Thr, Ile, Leu, 0.756, 0.710, 1.7%, 0.735, 0.724; Asn, Gln, Met, Lys, Leu, Phe, 0.756, 0.682, 0.2%, 0.656, 0.623; Asn, Gl

y, Ala, Cit, Tyr, Ile, 0.756, 0.722, 6.8%, 0.719, 0.698; Asn, Gly, Arg, Val, Lys, Ile, 0.756, 0.669, 3.1%, 0.656, 0.675; Asn, Gly, Cit, Lys, Ile, Phe, 0.756, 0.681, 1.7%, 0.659, 0.661; Asn, Gly, Cit, Orn, Lys, Ile, 0.756, 0.672, 2.0%, 0.656, 0.661; Asn, Gly, Cit, Tyr, Ile, Phe, 0.756, 0.714, 5.5%, 0.715, 0.690; Asn, Gly, Gln, His, Ile, Trp, 0.756, 0.703, 1.3%, 0.723, 0.696; Asn, Gly, Gln, Val, Lys, Ile, 0.756, 0.668, 2.0%, 0.642, 0.673; Asn, Gly, Tyr, Met, Ile, Leu, 0.756, 0.724, 7.0%, 0.705, 0.657; Asn, His, Ala, Arg, Tyr, Ile, 0.756, 0.728, 3.7%, 0.741, 0.718; Asn, His, Cit, Tyr, Orn, Leu, 0.756, 0.708, 2.6%, 0.710, 0.679; Asn, His, Lys, Ile, Phe, Trp, 0.756, 0.687, 1.5%, 0.670, 0.629; Asn, His, Tyr, Val, Met, Ile, 0.756, 0.735, 4.4%, 0.738, 0.708; Asn, Thr, Cit, Arg, Lys, Ile, 0.756, 0.674, 2.0%, 0.671, 0.690; Asn, Thr, Tyr, Met, Leu, Phe, 0.756, 0.732, 2.9%, 0.726, 0.661; Asn, Thr, Tyr, Met, Lys, Ile, 0.756, 0.716, 9.4%, 0.700, 0.702; Asn, Thr, Tyr, Val, Leu, Phe, 0.756, 0.731, 3.3%, 0.727, 0.661; Cit, Arg, Pro, Tyr, Orn, Lys, 0.756, 0.681, 7.0%, 0.678, 0.771; Cit, Arg, Tyr, Lys, Ile, Leu, 0.756, 0.712, 2.4%, 0.710, 0.734; Cit, Tyr, Lys, Ile, Phe, Trp, 0.756, 0.712, 4.6%, 0.703, 0.712; Gln, Ala, Arg, Orn, Lys, Ile, 0.756, 0.678, 1.3%, 0.677, 0.712; Gln, Arg, Tyr, Val, Lys, Ile, 0.756, 0.720, 4.6%, 0.732, 0.787; Gln, Cit, Arg, Val, Lys, Ile, 0.756, 0.682, 1.3%, 0.685, 0.748; Gln, Cit, Tyr, Ile, Phe, Trp, 0.756, 0.732, 4.4%, 0.747, 0.734; Gln, His, Ala, Tyr, Val, Trp, 0.756, 0.735, 4.6%, 0.728, 0.734; Gln, His, Lys, Ile, Phe, Trp, 0.756, 0.698, 0.6%, 0.697, 0.665; Gln, His, Met, Orn, Ile, Phe, 0.756, 0.691, 0.4%, 0.710, 0.677; Gln, His, Met, Orn, Lys, Ile, 0.756, 0.691, 0.9%, 0.684, 0.692; Gln, His, Thr, Lys, Ile, Phe, 0.756, 0.698, 0.6%, 0.695, 0.671; Gln, His, Thr, Orn, Ile, Phe, 0.756, 0.692, 0.4%, 0.711, 0.682; Gln, Orn, Lys, Ile, Leu, Phe, 0.756, 0.683, 0.6%, 0.659, 0.651; Gln, Thr, Arg, Tyr, Lys, Ile, 0.756, 0.725, 5.5%, 0.733, 0.773; Gln, Thr, Pro, Tyr, Leu, Phe, 0.756, 0.731, 2.9%, 0.735, 0.686; Gln, Thr, Tyr, Val, Leu, Phe, 0.756, 0.731, 1.7%, 0.733, 0.680; Gln, Tyr, Val, Met, Ile, Leu, 0.756, 0.731, 3.5%, 0.735, 0.716; Gly, Gln, Ala, Tyr, Met, Ile, 0.756, 0.729, 6.4%, 0.726, 0.718; Gly, Gln, Arg, Met, Lys, Ile, 0.756, 0.678, 0.9%, 0.668, 0.696; Gly, Gln, Arg, Pro, Tyr, Ile, 0.756, 0.725, 5.7%, 0.730, 0.734; Gly, Gln, Cit, Val, Lys, Ile, 0.756, 0.677, 1.3%, 0.661, 0.716; Gly, Gln, His, Cit, Arg, Ile, 0.756, 0.704, 0.9%, 0.718, 0.714; Gly, Gln, His, Met, Ile, Phe, 0.756, 0.700, 0.2%, 0.723, 0.684; Gly, Gln, His, Pro, Tyr, Leu, 0.756, 0.722, 3.1%, 0.719, 0.726; Gly, Gln, Tyr, Orn, Ile, Trp, 0.756, 0.730, 6.1%, 0.728, 0.740; Gly, Gln, Tyr, Orn, Lys, Ile, 0.756, 0.721, 4.6%, 0.707, 0.753; Gly, Gln, Tyr, Val, Met, Lys, 0.756, 0.730, 5.1%, 0.705, 0.704; His, Ala, Cit, Tyr, Met, Ile, 0.756, 0.727, 3.3%, 0.733, 0.734; His, Tyr, Met, Ile, Leu, Phe, 0.756, 0.723, 2.8%, 0.717, 0.673; His, Tyr, Val, Met, Ile, Phe, 0.756, 0.730, 3.5%, 0.726, 0.688; Ser, Asn, Gln, Val, Lys, Ile, 0.756, 0.655, 2.8%, 0.632, 0.690; Ser, Asn, Tyr, Lys, Leu, Phe, 0.756, 0.727, 2.0%, 0.705, 0.647; Ser, Gln, Arg, Lys, Ile, Leu, 0.756, 0.666, 0.2%, 0.655, 0.724; Ser, Gln, His, Arg, Lys, Ile, 0.756, 0.681, 0.2%, 0.680, 0.724; Ser, Gln, His, Cit, Ile, Trp, 0.756, 0.690, 1.3%, 0.702, 0.720; Ser, Gln, His, Cit, Pro, Ile, 0.756, 0.697, 1.7%, 0.716, 0.738; Ser, Gln, His, Tyr, Lys, Leu, 0.756, 0.724, 3.5%, 0.719, 0.738; Ser, Gln, Lys, Ile, Phe, Trp, 0.756, 0.665, 1.1%, 0.638, 0.675; Ser, Gln, Pro, Tyr, Leu, Phe, 0.756, 0.726, 2.2%, 0.725, 0.684; Ser, Gly, His, Tyr, Ile, Phe, 0.756, 0.716, 4.4%, 0.713, 0.677; Ser, His, Pro, Tyr, Ile, Phe, 0.756, 0.717, 3.7%, 0.713, 0.686; Thr, Arg, Tyr, Orn, Lys, Ile, 0.756, 0.709, 7.5%, 0.711, 0.738; Thr, Tyr, Met, Lys, Ile, Phe, 0.756, 0.720, 5.7%, 0.706, 0.694; Ala, Cit, Tyr, Lys, Ile, Trp, 0.756, 0.714, 5.7%, 0.702, 0.738; Asn, Ala, Arg, Orn, Lys, Ile, 0.756, 0.666, 3.3%, 0.662, 0.677; Asn, Ala, Cit, Orn, Lys, Ile, 0.756, 0.669, 2.2%, 0.657, 0.682; Asn, Ala, Cit, Tyr, Orn, Ile, 0.756, 0.715, 4.6%, 0.727, 0.726; Asn, Cit, Arg, Met, Lys, Ile, 0.756, 0.677, 1.8%, 0.672, 0.696; Asn, Cit, Orn, Lys, Ile, Phe, 0.756, 0.675, 1.8%, 0.657, 0.653; Asn, Cit, Pro, Tyr, Ile, Phe, 0.756, 0.726, 4.8%, 0.733, 0.684; Asn, Cit, Tyr, Orn, Ile, Trp, 0.756, 0.714, 6.1%, 0.724, 0.714; Asn, Gln, Ala, Tyr, Ile, Leu, 0.756, 0.725, 3.7%, 0.729, 0.702; Asn, Gln, Arg, Ile, Leu, Phe, 0.756, 0.697, 0.2%, 0.703, 0.639; Asn, Gln, Arg, Met, Lys, Ile, 0.756, 0.684, 2.4%, 0.679, 0.714; Asn, Gln, Cit, Lys, Ile, Trp, 0.756, 0.684, 1.5%, 0.672, 0.690; Asn, Gln, Cit, Tyr, Lys, Leu, 0.756, 0.726, 2.2%, 0.718, 0.718; Asn, Gln, Cit, Tyr, Orn, Leu, 0.756, 0.714, 2.8%, 0.719, 0.706; Asn, Gln, His, Orn, Leu, Phe, 0.756, 0.691, 0.0%, 0.688, 0.600; Asn, Gln, His, Orn, Lys, Leu, 0.756, 0.686, 1.5%, 0.667, 0.639; Asn, Gln, Ile, Leu, Phe, Trp, 0.756, 0.696, 0.2%, 0.704, 0.633; Asn, Gln, Lys, Ile, Leu, Trp, 0.756, 0.682, 1.1%, 0.660, 0.669; Asn, Gln, Thr, Val, Leu, Phe, 0.756, 0.683, 0.0%, 0.672, 0.613; Asn, Gln, Tyr, Val, Lys, Leu, 0.756, 0.725, 2.6%, 0.716, 0.712; Asn, Gly, Arg, Tyr, Ile, Leu, 0.756, 0.721, 5.5%, 0.711, 0.665; Asn, Gly, Cit, Lys, Ile, Trp, 0.756, 0.679, 1.5%, 0.660, 0.671; Asn, Gly, Gln, His, Lys, Leu, 0.756, 0.686, 0.4%, 0.661, 0.633; Asn, Gly, Gln, Orn, Leu, Phe, 0.756, 0.671, 0.2%, 0.652, 0.578; Asn, His, Arg, Tyr, Ile, Leu, 0.756, 0.726, 2.9%, 0.736, 0.704; Asn, His, Cit, Tyr, Ile, Phe, 0.756, 0.722, 2.4%, 0.741, 0.698; Asn, His, Pro, Tyr, Met, Ile, 0.756, 0.736, 3.7%, 0.742, 0.718; Asn, His, Thr, Tyr, Met, Ile, 0.756, 0.734, 4.4%, 0.743, 0.708; Asn, His, Val, Lys, Ile, Phe, 0.756, 0.683, 1.8%, 0.665, 0.625; Asn, Orn, Lys, Ile, Leu, Phe, 0.756, 0.680, 1.5%, 0.650, 0.627; Asn, Thr, Arg, Val, Lys, Ile, 0.756, 0.670, 2.9%, 0.663, 0.684; Asn, Thr, Lys, Ile, Leu, Phe, 0.756, 0.681, 1.5%, 0.649, 0.621; Asn, Thr, Pro, Tyr, Leu, Phe, 0.756, 0.726, 3.7%, 0.723, 0.647; Asn, Thr, Tyr, Leu, Phe, Trp, 0.756, 0.728, 3.9%, 0.720, 0.653; Asn, Tyr, Met, Lys, Ile, Phe, 0.756, 0.715, 7.5%, 0.691, 0.671; Asn, Tyr, Orn, Lys, Leu, Phe, 0.756, 0.721, 1.8%, 0.699, 0.643; Gln, Ala, Arg, Lys, Ile, Trp, 0.756, 0.683, 1.7%, 0.682, 0.720; Gln, Ala, Tyr, Ile, Leu, Trp, 0.756, 0.732, 5.7%, 0.726, 0.724; Gln, Ala, Tyr, Met, Lys, Ile, 0.756, 0.724, 5.1%, 0.718, 0.744; Gln, Arg, Met, Lys, Ile, Phe, 0.756, 0.680, 0.7%, 0.678, 0.698; Gln, Cit, Arg, Tyr, Orn, Ile, 0.756, 0.711, 3.3%, 0.729, 0.746; Gln, Cit, Tyr, Lys, Leu, Trp, 0.756, 0.730, 3.5%, 0.711, 0.730; Gln, His, Cit, Tyr, Lys, Ile, 0.756, 0.726, 2.9%, 0.740, 0.789; Gln, His, Met, Ile, Phe, Trp, 0.756, 0.706, 0.4%, 0.725, 0.692; Gln, His, Met, Lys, Ile, Phe, 0.756, 0.698, 0.6%, 0.695, 0.671; Gln, His, Orn, Lys, Leu, Phe, 0.756, 0.685, 0.2%, 0.666, 0.635; Gln, His, Pro, Orn, Ile, Phe, 0.756, 0.693, 0.6%, 0.710, 0.680; Gln, His, Thr, Ile, Phe, Trp, 0.756, 0.702, 0.4%, 0.720, 0.682; Gln, His, Tyr, Lys, Ile, Trp, 0.756, 0.725, 5.9%, 0.723, 0.748; Gln, Thr, Cit, Arg, Lys, Ile, 0.756, 0.686, 1.1%, 0.688, 0.732; Gln, Thr, Tyr, Ile, Leu, Trp, 0.756, 0.735, 5.9%, 0.731, 0.722; Gln, Tyr, Lys, Ile, Leu, Trp, 0.756, 0.723, 6.8%, 0.711, 0.730; Gln, Tyr, Met, Lys, Leu, Phe, 0.756, 0.725, 2.0%, 0.715, 0.694; Gln, Tyr, Orn, Ile, Leu, Trp, 0.756, 0.732, 6.1%, 0.727, 0.728; Gly, Arg, Tyr, Lys, Ile, Trp, 0.756, 0.710, 6.6%, 0.690, 0.702; Gly, Gln, His, Ala, Ile, Trp, 0.756, 0.703, 1.7%, 0.715, 0.708; Gly, Gln, His, Cit, Ile, Leu, 0.756, 0.704, 0.9%, 0.719, 0.714; Gly, Gln, His, Cit, Met, Ile, 0.756, 0.703, 0.9%, 0.716, 0.708; Gly, Gln, Lys, Ile, Phe, Trp, 0.756, 0.671, 0.7%, 0.642, 0.653; Gly, Gln, Thr, Ala, Tyr, Ile, 0.756, 0.729, 7.0%, 0.732, 0.734; Gly, Gln, Thr, Tyr, Ile, Leu, 0.756, 0.720, 6.2%, 0.716, 0.706; Gly, His, Cit, Tyr, Met, Ile, 0.756, 0.724, 2.9%, 0.722, 0.720; His, Ala, Tyr, Met, Ile, Trp, 0.756, 0.727, 5.1%, 0.725, 0.702; His, Arg, Tyr, Val, Ile, Phe, 0.756, 0.723, 2.9%, 0.729, 0.690; His, Cit, Tyr, Lys, Ile, Trp, 0.756, 0.715, 3.5%, 0.707, 0.732; His, Cit, Tyr, Met, Orn, Ile, 0.756, 0.712, 4.4%, 0.718, 0.712; Ser, Asn, Gln, His, Ile, Trp, 0.756, 0.692, 1.1%, 0.713, 0.718; Ser, Asn, Gln, His, Met, Ile, 0.756, 0.694, 0.2%, 0.714, 0.712; Ser, Asn, Gln, Lys, Ile, Trp, 0.756, 0.661, 2.6%, 0.636, 0.679; Ser, Asn, Gln, Tyr, Val, Ile, 0.756, 0.718, 5.7%, 0.719, 0.724; Ser, Asn, His, Cit, Lys, Ile, 0.756, 0.679, 2.6%, 0.669, 0.682; Ser, Asn, Thr, Tyr, Leu, Phe, 0.756, 0.730, 3.5%, 0.725, 0.659; Ser, Gln, Cit, Tyr, Leu, Phe, 0.756, 0.734, 1.8%, 0.736, 0.690; Ser, Gln, His, Arg, Ile, Trp, 0.756, 0.689, 0.6%, 0.709, 0.716; Ser, Gln, His, Arg, Orn, Ile, 0.756, 0.684, 0.6%, 0.705, 0.716; Ser, Gln, His, Met, Lys, Ile, 0.756, 0.685, 0.6%, 0.677, 0.712; Ser, Gln, His, Tyr, Leu, Phe, 0.756, 0.740, 1.3%, 0.748, 0.708; Ser, Gln, His, Val, Ile, Phe, 0.756, 0.685, 0.4%, 0.706, 0.694; Ser, Gln, Tyr, Val, Lys, Ile, 0.756, 0.706, 4.2%, 0.699, 0.767; Ser, Gly, Gln, Cit, Tyr, Ile, 0.756, 0.715, 3.7%, 0.720, 0.740; Ser, His, Ala, Tyr, Ile, Phe, 0.756, 0.711, 3.5%, 0.711, 0.680; Thr, Ala, Arg, Tyr, Lys, Ile, 0.756, 0.715, 7.5%, 0.716, 0.748; Ala, Arg, Tyr, Val, Lys, Ile, 0.755, 0.713, 3.5%, 0.709, 0.738; Arg, Pro, Tyr, Val, Lys, Ile, 0.755, 0.709, 4.8%, 0.708, 0.738; Asn, Ala, Arg, Pro, Tyr, Lys, 0.755, 0.704, 6.4%, 0.689, 0.740; Asn, Cit, Met, Lys, Ile, Leu, 0.755, 0.681, 1.5%, 0.668, 0.677; Asn, Cit, Tyr, Met, Ile, Leu, 0.755, 0.730, 4.2%, 0.731, 0.690; Asn, Gln, Ala, Lys, Ile, Trp, 0.755, 0.680, 2.0%, 0.663, 0.686; Asn, Gln, Arg, Pro, Lys, Ile, 0.755, 0.675, 2.2%, 0.669, 0.675; Asn, Gln, His, Pro, Tyr, Val, 0.755, 0.737, 2.4%, 0.734, 0.730; Asn, Gln, His, Tyr, Leu, Trp, 0.755, 0.735, 3.7%, 0.731, 0.708; Asn, Gln, His, Tyr, Orn, Lys, 0.755, 0.723, 4.4%, 0.722, 0.753; Asn, Gln, His, Tyr, Val, Trp, 0.755, 0.742, 3.5%, 0.737, 0.732; Asn, Gln, Pro, Tyr, Ile, Leu, 0.755, 0.727, 3.5%, 0.730, 0.698; Asn, Gln, Tyr, Val, Ile, Phe, 0.755, 0.731, 6.8%, 0.735, 0.700; Asn, Gly, Arg, Tyr, Val, Lys, 0.755, 0.720, 5.0%, 0.705, 0.706; Asn, Gly, Cit, Tyr, Leu, Phe, 0.755, 0.715, 2.9%, 0.697, 0.621; Asn, Gly, Cit, Tyr, Orn, Leu, 0.755, 0.708, 2.8%, 0.697, 0.647; Asn, Gly, Gln, Cit, Lys, Leu, 0.755, 0.675, 0.2%, 0.640, 0.598; Asn, Gly, Gln, His, Thr, Ile, 0.755, 0.703, 1.3%, 0.726, 0.704; Asn, Gly

, His, Pro, Tyr, Ile, 0.755, 0.724, 4.6%, 0.725, 0.702; Asn, Gly, Tyr, Lys, Leu, Trp, 0.755, 0.714, 3.7%, 0.684, 0.643; Asn, His, Ala, Tyr, Met, Ile, 0.755, 0.733, 4.2%, 0.740, 0.704; Asn, His, Arg, Tyr, Ile, Phe, 0.755, 0.721, 1.8%, 0.737, 0.679; Asn, His, Arg, Tyr, Ile, Trp, 0.755, 0.733, 5.9%, 0.745, 0.730; Asn, His, Thr, Cit, Lys, Ile, 0.755, 0.691, 3.5%, 0.684, 0.661; Asn, His, Tyr, Met, Orn, Ile, 0.755, 0.731, 4.4%, 0.738, 0.706; Asn, Pro, Tyr, Met, Leu, Phe, 0.755, 0.722, 2.8%, 0.713, 0.641; Asn, Thr, Arg, Lys, Ile, Leu, 0.755, 0.674, 1.7%, 0.667, 0.677; Asn, Thr, Arg, Met, Lys, Ile, 0.755, 0.674, 1.8%, 0.670, 0.688; Asn, Tyr, Met, Leu, Phe, Trp, 0.755, 0.727, 2.9%, 0.711, 0.645; Asn, Tyr, Met, Lys, Leu, Phe, 0.755, 0.726, 2.2%, 0.705, 0.643; Gln, Ala, Cit, Tyr, Ile, Phe, 0.755, 0.727, 3.7%, 0.747, 0.726; Gln, Ala, Tyr, Leu, Phe, Trp, 0.755, 0.725, 2.6%, 0.720, 0.679; Gln, Arg, Met, Orn, Lys, Ile, 0.755, 0.680, 1.1%, 0.675, 0.708; Gln, Cit, Arg, Tyr, Ile, Phe, 0.755, 0.729, 2.8%, 0.748, 0.722; Gln, Cit, Arg, Tyr, Leu, Phe, 0.755, 0.733, 1.7%, 0.738, 0.696; Gln, His, Ala, Arg, Val, Ile, 0.755, 0.706, 0.9%, 0.735, 0.732; Gln, His, Ala, Ile, Leu, Trp, 0.755, 0.708, 1.8%, 0.718, 0.708; Gln, His, Arg, Orn, Lys, Ile, 0.755, 0.689, 1.1%, 0.697, 0.702; Gln, His, Arg, Val, Orn, Ile, 0.755, 0.696, 0.9%, 0.721, 0.712; Gln, His, Cit, Val, Lys, Ile, 0.755, 0.699, 1.3%, 0.710, 0.750; Gln, His, Pro, Val, Ile, Phe, 0.755, 0.703, 0.4%, 0.725, 0.680; Gln, His, Thr, Met, Orn, Ile, 0.755, 0.699, 0.9%, 0.715, 0.704; Gln, His, Tyr, Orn, Lys, Ile, 0.755, 0.722, 3.1%, 0.729, 0.771; Gln, His, Tyr, Orn, Lys, Leu, 0.755, 0.719, 2.4%, 0.715, 0.742; Gln, His, Tyr, Val, Lys, Leu, 0.755, 0.724, 3.1%, 0.718, 0.744; Gln, His, Tyr, Val, Lys, Trp, 0.755, 0.734, 6.6%, 0.721, 0.746; Gln, Pro, Tyr, Met, Lys, Ile, 0.755, 0.723, 5.0%, 0.716, 0.740; Gln, Pro, Tyr, Orn, Leu, Phe, 0.755, 0.722, 3.1%, 0.720, 0.682; Gln, Pro, Tyr, Val, Leu, Phe, 0.755, 0.726, 2.4%, 0.727, 0.682; Gln, Thr, Arg, Met, Lys, Ile, 0.755, 0.686, 1.1%, 0.685, 0.722; Gly, Arg, Tyr, Lys, Leu, Trp, 0.755, 0.713, 3.7%, 0.687, 0.671; Gly, Arg, Tyr, Met, Lys, Leu, 0.755, 0.717, 1.8%, 0.695, 0.675; Gly, Gln, Ala, Arg, Tyr, Ile, 0.755, 0.727, 6.1%, 0.732, 0.734; Gly, Gln, Arg, Tyr, Val, Lys, 0.755, 0.725, 3.5%, 0.710, 0.714; Gly, Gln, Cit, Arg, Tyr, Ile, 0.755, 0.722, 3.5%, 0.727, 0.740; Gly, Gln, His, Pro, Met, Ile, 0.755, 0.702, 0.9%, 0.718, 0.704; Gly, Gln, Tyr, Met, Leu, Trp, 0.755, 0.727, 4.4%, 0.705, 0.677; Gly, Gln, Tyr, Orn, Ile, Leu, 0.755, 0.726, 4.0%, 0.720, 0.724; Gly, His, Thr, Tyr, Ile, Phe, 0.755, 0.720, 2.9%, 0.727, 0.675; His, Ala, Arg, Lys, Ile, Phe, 0.755, 0.679, 0.2%, 0.669, 0.675; His, Ala, Tyr, Ile, Leu, Phe, 0.755, 0.712, 3.1%, 0.705, 0.671; His, Arg, Tyr, Lys, Ile, Leu, 0.755, 0.712, 2.8%, 0.709, 0.736; His, Tyr, Lys, Ile, Leu, Phe, 0.755, 0.710, 3.5%, 0.695, 0.659; Ser, Asn, Gln, Cit, Lys, Ile, 0.755, 0.668, 2.0%, 0.651, 0.688; Ser, Asn, Gln, Cit, Tyr, Ile, 0.755, 0.720, 3.3%, 0.738, 0.753; Ser, Asn, Gln, His, Ile, Leu, 0.755, 0.694, 0.4%, 0.715, 0.720; Ser, Asn, Gln, His, Orn, Leu, 0.755, 0.693, 0.9%, 0.692, 0.637; Ser, Asn, His, Pro, Tyr, Ile, 0.755, 0.722, 4.0%, 0.729, 0.712; Ser, Gln, His, Ala, Cit, Ile, 0.755, 0.690, 0.9%, 0.708, 0.736; Ser, Gln, His, Cit, Val, Ile, 0.755, 0.691, 1.1%, 0.713, 0.740; Ser, Gln, Pro, Tyr, Ile, Trp, 0.755, 0.714, 7.5%, 0.713, 0.759; Ser, Gly, Cit, Tyr, Val, Ile, 0.755, 0.721, 5.3%, 0.711, 0.720; Ser, Gly, Gln, Ala, Tyr, Ile, 0.755, 0.718, 5.9%, 0.720, 0.740; Ser, Gly, Gln, Tyr, Met, Ile, 0.755, 0.720, 5.3%, 0.714, 0.724; Thr, Tyr, Lys, Ile, Phe, Trp, 0.755, 0.717, 5.7%, 0.702, 0.688; Arg, Pro, Tyr, Lys, Ile, Leu, 0.754, 0.709, 4.2%, 0.703, 0.734; Arg, Tyr, Val, Lys, Ile, Leu, 0.754, 0.710, 3.5%, 0.705, 0.736; Asn, Arg, Met, Lys, Ile, Leu, 0.754, 0.675, 1.7%, 0.669, 0.686; Asn, Cit, Met, Orn, Lys, Ile, 0.754, 0.671, 2.0%, 0.658, 0.661; Asn, Cit, Pro, Lys, Ile, Trp, 0.754, 0.680, 1.8%, 0.664, 0.692; Asn, Cit, Pro, Tyr, Orn, Ile, 0.754, 0.714, 4.4%, 0.727, 0.728; Asn, Gln, Cit, Lys, Ile, Leu, 0.754, 0.685, 1.3%, 0.673, 0.686; Asn, Gln, His, Thr, Orn, Leu, 0.754, 0.693, 0.9%, 0.694, 0.639; Asn, Gln, Orn, Ile, Leu, Phe, 0.754, 0.686, 0.2%, 0.685, 0.625; Asn, Gln, Thr, Lys, Ile, Leu, 0.754, 0.683, 1.5%, 0.662, 0.675; Asn, Gln, Thr, Lys, Ile, Phe, 0.754, 0.678, 1.1%, 0.656, 0.649; Asn, Gln, Thr, Orn, Leu, Phe, 0.754, 0.677, 0.0%, 0.664, 0.596; Asn, Gln, Thr, Val, Lys, Leu, 0.754, 0.681, 0.2%, 0.651, 0.625; Asn, Gln, Tyr, Lys, Ile, Trp, 0.754, 0.719, 7.4%, 0.708, 0.710; Asn, Gln, Tyr, Orn, Ile, Leu, 0.754, 0.724, 3.7%, 0.728, 0.702; Asn, Gln, Tyr, Val, Ile, Trp, 0.754, 0.734, 7.7%, 0.729, 0.726; Asn, Gly, Arg, Tyr, Met, Ile, 0.754, 0.726, 5.5%, 0.722, 0.682; Asn, Gly, Arg, Tyr, Val, Ile, 0.754, 0.724, 5.9%, 0.716, 0.680; Asn, Gly, Cit, Tyr, Lys, Leu, 0.754, 0.710, 2.4%, 0.689, 0.653; Asn, Gly, Gln, Pro, Tyr, Ile, 0.754, 0.723, 6.2%, 0.720, 0.710; Asn, Gly, His, Tyr, Ile, Phe, 0.754, 0.717, 3.5%, 0.720, 0.665; Asn, Gly, Thr, Lys, Ile, Leu, 0.754, 0.679, 1.5%, 0.649, 0.647; Asn, Gly, Thr, Tyr, Lys, Leu, 0.754, 0.715, 5.5%, 0.691, 0.649; Asn, Gly, Tyr, Leu, Phe, Trp, 0.754, 0.717, 3.3%, 0.695, 0.627; Asn, His, Ala, Arg, Lys, Ile, 0.754, 0.682, 2.2%, 0.682, 0.684; Asn, His, Ala, Tyr, Ile, Leu, 0.754, 0.724, 5.3%, 0.722, 0.684; Asn, His, Ala, Tyr, Ile, Phe, 0.754, 0.722, 3.5%, 0.728, 0.669; Asn, His, Thr, Cit, Tyr, Ile, 0.754, 0.728, 4.2%, 0.747, 0.730; Asn, His, Tyr, Met, Leu, Phe, 0.754, 0.733, 1.7%, 0.724, 0.657; Asn, Thr, Met, Lys, Ile, Leu, 0.754, 0.680, 1.7%, 0.655, 0.659; Cit, Arg, Tyr, Val, Lys, Ile, 0.754, 0.712, 2.6%, 0.712, 0.736; Gln, Arg, Tyr, Orn, Leu, Phe, 0.754, 0.720, 1.7%, 0.727, 0.684; Gln, Arg, Val, Ile, Leu, Phe, 0.754, 0.695, 0.2%, 0.702, 0.635; Gln, Cit, Arg, Ile, Leu, Phe, 0.754, 0.695, 0.2%, 0.702, 0.651; Gln, Cit, Tyr, Ile, Leu, Trp, 0.754, 0.734, 3.7%, 0.738, 0.742; Gln, Cit, Tyr, Met, Ile, Phe, 0.754, 0.727, 3.9%, 0.748, 0.734; Gln, Cit, Tyr, Met, Orn, Ile, 0.754, 0.710, 3.7%, 0.728, 0.736; Gln, Cit, Tyr, Orn, Lys, Leu, 0.754, 0.710, 2.2%, 0.708, 0.742; Gln, Cit, Tyr, Val, Leu, Phe, 0.754, 0.729, 1.7%, 0.731, 0.686; Gln, His, Ala, Met, Orn, Ile, 0.754, 0.693, 1.1%, 0.714, 0.700; Gln, His, Arg, Tyr, Val, Orn, 0.754, 0.726, 1.5%, 0.737, 0.746; Gln, His, Cit, Tyr, Leu, Phe, 0.754, 0.732, 1.5%, 0.739, 0.712; Gln, His, Cit, Tyr, Val, Orn, 0.754, 0.715, 1.8%, 0.723, 0.746; Gln, His, Lys, Ile, Leu, Phe, 0.754, 0.696, 0.4%, 0.699, 0.688; Gln, His, Pro, Ile, Leu, Phe, 0.754, 0.702, 0.2%, 0.720, 0.671; Gln, His, Pro, Met, Ile, Phe, 0.754, 0.703, 0.4%, 0.724, 0.679; Gln, His, Pro, Tyr, Lys, Ile, 0.754, 0.723, 2.9%, 0.729, 0.771; Gln, His, Thr, Ala, Ile, Trp, 0.754, 0.705, 1.8%, 0.724, 0.718; Gln, His, Thr, Ile, Leu, Phe, 0.754, 0.700, 0.0%, 0.719, 0.688; Gln, His, Thr, Val, Met, Ile, 0.754, 0.710, 0.4%, 0.729, 0.736; Gln, Lys, Ile, Leu, Phe, Trp, 0.754, 0.684, 0.6%, 0.660, 0.653; Gln, Thr, Ala, Tyr, Ile, Leu, 0.754, 0.729, 4.6%, 0.735, 0.740; Gln, Thr, Lys, Ile, Leu, Phe, 0.754, 0.684, 0.6%, 0.660, 0.653; Gln, Tyr, Met, Lys, Leu, Trp, 0.754, 0.732, 3.7%, 0.713, 0.714; Gly, Cit, Tyr, Ile, Leu, Trp, 0.754, 0.713, 4.0%, 0.697, 0.692; Gly, Gln, Ala, Cit, Tyr, Leu, 0.754, 0.718, 2.2%, 0.709, 0.706; Gly, Gln, Ala, Tyr, Lys, Leu, 0.754, 0.718, 3.5%, 0.698, 0.716; Gly, Gln, Cit, Arg, Lys, Ile, 0.754, 0.679, 1.1%, 0.670, 0.702; Gly, Gln, Cit, Arg, Orn, Ile, 0.754, 0.678, 1.8%, 0.679, 0.671; Gly, Gln, Cit, Lys, Ile, Phe, 0.754, 0.676, 0.9%, 0.653, 0.663; Gly, Gln, His, Arg, Lys, Ile, 0.754, 0.691, 0.6%, 0.692, 0.700; Gly, Gln, His, Tyr, Orn, Ile, 0.754, 0.727, 3.1%, 0.743, 0.755; Gly, Gln, His, Val, Lys, Ile, 0.754, 0.690, 1.7%, 0.689, 0.728; Gly, Gln, Thr, Pro, Tyr, Ile, 0.754, 0.725, 5.7%, 0.728, 0.734; Gly, Gln, Tyr, Orn, Lys, Leu, 0.754, 0.719, 3.5%, 0.700, 0.718; Gly, Gln, Tyr, Val, Lys, Leu, 0.754, 0.721, 4.0%, 0.703, 0.720; Gly, Thr, Cit, Tyr, Ile, Phe, 0.754, 0.715, 5.1%, 0.717, 0.692; His, Ala, Pro, Tyr, Ile, Phe, 0.754, 0.706, 3.5%, 0.705, 0.696; His, Cit, Tyr, Met, Lys, Ile, 0.754, 0.722, 4.2%, 0.715, 0.732; His, Cit, Tyr, Orn, Ile, Trp, 0.754, 0.700, 3.9%, 0.705, 0.728; His, Pro, Tyr, Ile, Leu, Phe, 0.754, 0.711, 2.9%, 0.703, 0.663; His, Pro, Tyr, Lys, Ile, Phe, 0.754, 0.705, 3.7%, 0.693, 0.686; His, Pro, Tyr, Orn, Ile, Phe, 0.754, 0.721, 2.9%, 0.717, 0.702; His, Thr, Pro, Tyr, Ile, Phe, 0.754, 0.723, 2.6%, 0.732, 0.679; His, Thr, Tyr, Met, Ile, Trp, 0.754, 0.728, 5.5%, 0.728, 0.700; His, Tyr, Met, Orn, Ile, Trp, 0.754, 0.728, 4.8%, 0.727, 0.698; His, Tyr, Val, Met, Ile, Trp, 0.754, 0.729, 9.2%, 0.720, 0.692; Ser, Asn, Cit, Tyr, Ile, Leu, 0.754, 0.719, 3.1%, 0.722, 0.714; Ser, Asn, Gln, Ala, Tyr, Ile, 0.754, 0.713, 4.8%, 0.721, 0.730; Ser, Asn, Gln, Lys, Ile, Phe, 0.754, 0.660, 1.8%, 0.636, 0.655; Ser, Asn, Gln, Thr, Lys, Ile, 0.754, 0.661, 2.6%, 0.637, 0.679; Ser, Asn, Gln, Tyr, Lys, Leu, 0.754, 0.725, 2.6%, 0.713, 0.712; Ser, Asn, His, Lys, Ile, Phe, 0.754, 0.674, 1.7%, 0.655, 0.633; Ser, Gln, Ala, Tyr, Lys, Ile, 0.754, 0.709, 4.6%, 0.703, 0.761; Ser, Gln, Arg, Tyr, Ile, Trp, 0.754, 0.716, 5.1%, 0.723, 0.751; Ser, Gln, Cit, Tyr, Ile, Trp, 0.754, 0.717, 3.7%, 0.723, 0.763; Ser, Gln, His, Cit, Arg, Ile, 0.754, 0.693, 0.9%, 0.711, 0.736; Ser, Gln, His, Pro, Tyr, Ile, 0.754, 0.724, 2.6%, 0.745, 0.773; Ser, Gln, Pro, Tyr, Lys, Ile, 0.754, 0.707, 4.2%, 0.703, 0.757; Ser, Gln, Tyr, Orn, Leu, Phe, 0.754, 0.723, 2.4%, 0.723, 0.679; Thr, Cit, Arg, Tyr, Lys, Ile, 0.754, 0.717, 6.8%, 0.718, 0.750; Thr, Cit, Tyr, Lys, Ile, Trp, 0.754, 0.717, 7.5%, 0.710, 0.742; Arg, Met, Lys, Ile, Phe, Trp, 0.754, 0.674, 0.7%, 0.662, 0.677; Arg, Met, Orn, Lys, Ile, Phe, 0.754, 0.669, 0.7%, 0.658, 0.667; Arg, Orn, Lys, Ile, Phe, Trp, 0.754, 0.668, 0.7%, 0.657, 0.663; Arg, Tyr, Met, Lys, Leu, Phe, 0.754, 0.723, 2.4%, 0.712, 0.661; Arg, Tyr, Val, Orn, Lys, Trp, 0.754, 0.718, 5.7%, 0.703, 0.722; Arg, Val, Met, Lys, Ile, Phe, 0.754, 0.674, 0.7%, 0.663, 0.675; Asn, Gln, Ala, Lys, Ile, Leu, 0.754, 0.681, 2.0%, 0.665, 0.671; Asn, Gln, Arg, Tyr, Ile, Phe, 0.754, 0.729, 5.0%, 0.743, 0.700; Asn, Gln, His, Ala, Orn, Leu, 0.754, 0.685, 0.6%, 0.685, 0.639; Asn, Gln, His, Orn, Leu, Trp, 0.754, 0.694, 0.9%, 0.694, 0.637; Asn, Gln, His, Thr, Ile, Trp, 0.754, 0.705, 1.8%, 0.728, 0.710; Asn, Gln,

 His, Tyr, Val, Lys, 0.754, 0.734, 4.4%, 0.724, 0.734; Asn, Gln, Tyr, Val, Lys, Ile, 0.754, 0.717, 6.4%, 0.706, 0.718; Asn, Gln, Val, Orn, Lys, Ile, 0.754, 0.672, 2.0%, 0.650, 0.684; Asn, Gln, Val, Orn, Lys, Leu, 0.754, 0.671, 0.2%, 0.643, 0.607; Asn, Gly, Ala, Cit, Lys, Ile, 0.754, 0.678, 1.8%, 0.664, 0.688; Asn, Gly, Gln, Ala, Tyr, Val, 0.754, 0.734, 7.9%, 0.713, 0.694; Asn, Gly, His, Tyr, Val, Ile, 0.754, 0.720, 5.3%, 0.715, 0.682; Asn, Gly, Tyr, Met, Leu, Phe, 0.754, 0.720, 3.1%, 0.698, 0.619; Asn, His, Arg, Ile, Leu, Phe, 0.754, 0.692, 0.0%, 0.691, 0.623; Asn, His, Arg, Pro, Ile, Phe, 0.754, 0.690, 0.2%, 0.700, 0.635; Asn, His, Pro, Tyr, Ile, Phe, 0.754, 0.725, 2.6%, 0.733, 0.680; Asn, His, Pro, Tyr, Val, Ile, 0.754, 0.728, 5.5%, 0.735, 0.710; Asn, His, Tyr, Lys, Ile, Trp, 0.754, 0.714, 6.1%, 0.704, 0.686; Asn, His, Tyr, Lys, Leu, Phe, 0.754, 0.722, 1.7%, 0.704, 0.643; Asn, His, Tyr, Orn, Lys, Ile, 0.754, 0.717, 6.1%, 0.708, 0.710; Asn, Thr, Cit, Val, Lys, Ile, 0.754, 0.681, 1.8%, 0.669, 0.682; Gln, Ala, Cit, Tyr, Orn, Ile, 0.754, 0.711, 3.5%, 0.729, 0.746; Gln, Ala, Tyr, Met, Ile, Leu, 0.754, 0.729, 3.5%, 0.733, 0.718; Gln, Arg, Ile, Leu, Phe, Trp, 0.754, 0.697, 0.2%, 0.701, 0.639; Gln, Arg, Met, Lys, Ile, Leu, 0.754, 0.686, 1.3%, 0.686, 0.734; Gln, Arg, Tyr, Lys, Ile, Leu, 0.754, 0.722, 4.0%, 0.729, 0.773; Gln, Arg, Tyr, Met, Ile, Leu, 0.754, 0.733, 2.9%, 0.737, 0.724; Gln, Arg, Tyr, Orn, Leu, Trp, 0.754, 0.721, 3.1%, 0.719, 0.704; Gln, Arg, Tyr, Orn, Lys, Leu, 0.754, 0.712, 1.7%, 0.711, 0.730; Gln, Cit, Arg, Tyr, Lys, Ile, 0.754, 0.720, 3.9%, 0.732, 0.785; Gln, Cit, Tyr, Met, Leu, Phe, 0.754, 0.731, 1.8%, 0.731, 0.688; Gln, Cit, Val, Ile, Leu, Phe, 0.754, 0.694, 0.2%, 0.703, 0.651; Gln, His, Ala, Arg, Pro, Ile, 0.754, 0.707, 0.9%, 0.735, 0.726; Gln, His, Arg, Lys, Ile, Trp, 0.754, 0.698, 1.3%, 0.701, 0.710; Gln, His, Arg, Orn, Ile, Leu, 0.754, 0.697, 0.9%, 0.721, 0.710; Gln, His, Arg, Orn, Ile, Trp, 0.754, 0.695, 1.5%, 0.714, 0.690; Gln, His, Arg, Pro, Met, Ile, 0.754, 0.709, 1.1%, 0.734, 0.714; Gln, His, Cit, Tyr, Lys, Leu, 0.754, 0.723, 1.8%, 0.724, 0.748; Gln, His, Cit, Tyr, Orn, Leu, 0.754, 0.712, 1.8%, 0.721, 0.744; Gln, His, Pro, Val, Met, Ile, 0.754, 0.708, 1.1%, 0.730, 0.726; Gln, His, Thr, Met, Ile, Phe, 0.754, 0.700, 0.4%, 0.721, 0.690; Gln, His, Thr, Pro, Met, Ile, 0.754, 0.709, 1.1%, 0.727, 0.726; Gln, His, Tyr, Val, Lys, Phe, 0.754, 0.739, 1.8%, 0.731, 0.712; Gln, His, Val, Met, Ile, Trp, 0.754, 0.709, 0.9%, 0.725, 0.706; Gln, Thr, Arg, Tyr, Ile, Leu, 0.754, 0.732, 3.1%, 0.740, 0.742; Gln, Thr, Cit, Tyr, Leu, Phe, 0.754, 0.731, 1.7%, 0.734, 0.686; Gln, Tyr, Met, Orn, Ile, Leu, 0.754, 0.727, 3.9%, 0.728, 0.706; Gln, Tyr, Met, Orn, Lys, Ile, 0.754, 0.726, 4.8%, 0.719, 0.748; Gln, Tyr, Val, Lys, Leu, Trp, 0.754, 0.727, 4.4%, 0.704, 0.728; Gly, Cit, Tyr, Met, Ile, Phe, 0.754, 0.712, 4.6%, 0.707, 0.686; Gly, Gln, Ala, Pro, Tyr, Ile, 0.754, 0.728, 5.0%, 0.731, 0.744; Gly, Gln, Arg, Tyr, Leu, Trp, 0.754, 0.727, 3.9%, 0.713, 0.688; Gly, Gln, Arg, Tyr, Met, Ile, 0.754, 0.725, 6.4%, 0.725, 0.724; Gly, Gln, Cit, Orn, Ile, Phe, 0.754, 0.680, 1.5%, 0.683, 0.657; Gly, Gln, His, Ala, Lys, Ile, 0.754, 0.693, 1.3%, 0.686, 0.708; Gly, Gln, His, Cit, Val, Ile, 0.754, 0.704, 0.9%, 0.720, 0.724; Gly, Gln, His, Lys, Ile, Trp, 0.754, 0.699, 2.0%, 0.686, 0.692; Gly, Gln, His, Tyr, Val, Ile, 0.754, 0.725, 3.1%, 0.741, 0.753; Gly, Gln, Thr, Arg, Tyr, Leu, 0.754, 0.723, 3.9%, 0.717, 0.696; Gly, Gln, Thr, Lys, Leu, Phe, 0.754, 0.675, 0.2%, 0.642, 0.613; Gly, Gln, Thr, Tyr, Lys, Leu, 0.754, 0.720, 5.9%, 0.705, 0.716; Gly, Gln, Thr, Tyr, Met, Ile, 0.754, 0.727, 6.1%, 0.723, 0.720; Gly, Gln, Val, Lys, Ile, Phe, 0.754, 0.669, 1.3%, 0.640, 0.661; Gly, His, Ala, Tyr, Ile, Phe, 0.754, 0.706, 3.3%, 0.703, 0.686; Gly, His, Tyr, Ile, Leu, Phe, 0.754, 0.710, 3.3%, 0.700, 0.657; Gly, Tyr, Met, Ile, Leu, Phe, 0.754, 0.717, 4.8%, 0.700, 0.643; His, Arg, Tyr, Lys, Ile, Trp, 0.754, 0.716, 5.9%, 0.705, 0.722; His, Arg, Tyr, Met, Ile, Trp, 0.754, 0.734, 5.5%, 0.738, 0.724; His, Thr, Tyr, Met, Orn, Ile, 0.754, 0.725, 6.1%, 0.730, 0.702; His, Thr, Tyr, Orn, Ile, Phe, 0.754, 0.724, 2.9%, 0.731, 0.677; Ser, Asn, Gln, His, Pro, Ile, 0.754, 0.692, 0.7%, 0.710, 0.716; Ser, Asn, Gln, Lys, Ile, Leu, 0.754, 0.664, 2.6%, 0.638, 0.671; Ser, Asn, Gln, Orn, Lys, Ile, 0.754, 0.663, 2.6%, 0.638, 0.680; Ser, Asn, Gln, Orn, Lys, Leu, 0.754, 0.666, 0.2%, 0.637, 0.609; Ser, Asn, His, Tyr, Ile, Leu, 0.754, 0.720, 5.3%, 0.720, 0.692; Ser, Asn, His, Tyr, Ile, Phe, 0.754, 0.721, 3.3%, 0.728, 0.673; Ser, Gln, Ala, Tyr, Ile, Trp, 0.754, 0.716, 7.0%, 0.714, 0.753; Ser, Gln, Cit, Tyr, Ile, Leu, 0.754, 0.717, 3.1%, 0.728, 0.751; Ser, Gln, His, Ala, Tyr, Leu, 0.754, 0.725, 2.0%, 0.730, 0.750; Ser, Gln, His, Arg, Val, Ile, 0.754, 0.690, 0.6%, 0.710, 0.746; Ser, Gln, His, Cit, Ile, Leu, 0.754, 0.692, 1.1%, 0.711, 0.740; Ser, Gln, His, Cit, Met, Ile, 0.754, 0.692, 1.1%, 0.709, 0.734; Ser, Gln, Tyr, Orn, Lys, Ile, 0.754, 0.715, 4.2%, 0.708, 0.769; Ser, Gly, Gln, His, Tyr, Ile, 0.754, 0.725, 3.1%, 0.741, 0.755; Ser, Gly, Gln, His, Tyr, Leu, 0.754, 0.729, 2.4%, 0.726, 0.718; Ser, Thr, Tyr, Lys, Ile, Phe, 0.754, 0.709, 5.3%, 0.695, 0.690; Thr, Tyr, Lys, Ile, Leu, Phe, 0.754, 0.720, 4.0%, 0.713, 0.684; Tyr, Orn, Lys, Ile, Leu, Phe, 0.754, 0.719, 3.7%, 0.701, 0.679; Ala, Arg, Lys, Ile, Leu, Phe, 0.753, 0.672, 0.2%, 0.667, 0.677; Arg, Val, Orn, Lys, Ile, Phe, 0.753, 0.667, 0.7%, 0.659, 0.663; Asn, Arg, Met, Lys, Ile, Trp, 0.753, 0.673, 1.8%, 0.667, 0.684; Asn, Arg, Val, Lys, Ile, Trp, 0.753, 0.670, 2.8%, 0.662, 0.684; Asn, Cit, Pro, Lys, Ile, Leu, 0.753, 0.681, 1.7%, 0.665, 0.673; Asn, Cit, Tyr, Ile, Leu, Trp, 0.753, 0.727, 5.1%, 0.725, 0.696; Asn, Cit, Tyr, Lys, Leu, Trp, 0.753, 0.719, 2.4%, 0.696, 0.675; Asn, Gln, Ala, Orn, Lys, Ile, 0.753, 0.678, 2.2%, 0.661, 0.684; Asn, Gln, Ala, Tyr, Leu, Phe, 0.753, 0.722, 1.8%, 0.727, 0.680; Asn, Gln, Ala, Tyr, Leu, Trp, 0.753, 0.728, 4.6%, 0.718, 0.702; Asn, Gln, Ala, Val, Lys, Ile, 0.753, 0.673, 2.4%, 0.658, 0.692; Asn, Gln, Cit, Tyr, Leu, Trp, 0.753, 0.734, 2.9%, 0.728, 0.708; Asn, Gln, His, Ala, Tyr, Val, 0.753, 0.736, 2.4%, 0.733, 0.730; Asn, Gln, His, Met, Orn, Leu, 0.753, 0.692, 0.9%, 0.692, 0.637; Asn, Gln, His, Pro, Tyr, Lys, 0.753, 0.729, 4.8%, 0.726, 0.750; Asn, Gln, His, Val, Orn, Leu, 0.753, 0.692, 0.9%, 0.692, 0.635; Asn, Gln, Lys, Leu, Phe, Trp, 0.753, 0.674, 0.0%, 0.647, 0.607; Asn, Gln, Met, Lys, Ile, Phe, 0.753, 0.676, 0.6%, 0.655, 0.657; Asn, Gln, Met, Lys, Ile, Trp, 0.753, 0.680, 2.0%, 0.659, 0.682; Asn, Gln, Orn, Lys, Ile, Trp, 0.753, 0.676, 2.2%, 0.654, 0.677; Asn, Gln, Pro, Tyr, Lys, Leu, 0.753, 0.722, 2.6%, 0.710, 0.698; Asn, Gln, Thr, Orn, Lys, Ile, 0.753, 0.675, 1.7%, 0.651, 0.680; Asn, Gln, Thr, Tyr, Leu, Trp, 0.753, 0.736, 5.3%, 0.724, 0.702; Asn, Gln, Thr, Val, Lys, Ile, 0.753, 0.673, 1.8%, 0.653, 0.690; Asn, Gln, Tyr, Orn, Lys, Ile, 0.753, 0.726, 6.2%, 0.716, 0.716; Asn, Gly, Ala, Arg, Lys, Ile, 0.753, 0.669, 3.9%, 0.656, 0.673; Asn, Gly, Arg, Pro, Lys, Ile, 0.753, 0.668, 2.8%, 0.651, 0.657; Asn, Gly, Cit, Tyr, Leu, Trp, 0.753, 0.717, 4.0%, 0.693, 0.643; Asn, Gly, Cit, Tyr, Val, Leu, 0.753, 0.720, 3.1%, 0.705, 0.661; Asn, Gly, Gln, Tyr, Met, Leu, 0.753, 0.724, 3.1%, 0.713, 0.663; Asn, Gly, His, Arg, Lys, Ile, 0.753, 0.679, 1.7%, 0.675, 0.665; Asn, Gly, His, Tyr, Ile, Leu, 0.753, 0.717, 4.6%, 0.711, 0.675; Asn, Gly, Pro, Tyr, Lys, Leu, 0.753, 0.712, 3.1%, 0.685, 0.653; Asn, His, Arg, Ile, Phe, Trp, 0.753, 0.692, 0.0%, 0.699, 0.635; Asn, His, Cit, Arg, Lys, Ile, 0.753, 0.685, 1.7%, 0.689, 0.680; Asn, His, Pro, Met, Lys, Ile, 0.753, 0.685, 3.7%, 0.663, 0.627; Asn, His, Pro, Tyr, Ile, Trp, 0.753, 0.726, 6.2%, 0.732, 0.714; Asn, His, Tyr, Val, Ile, Leu, 0.753, 0.723, 5.3%, 0.722, 0.682; Asn, Tyr, Ile, Leu, Phe, Trp, 0.753, 0.724, 3.7%, 0.712, 0.649; Asn, Tyr, Met, Orn, Lys, Ile, 0.753, 0.723, 8.1%, 0.702, 0.696; Asn, Tyr, Val, Met, Leu, Phe, 0.753, 0.728, 2.4%, 0.718, 0.643; Asn, Val, Lys, Ile, Leu, Phe, 0.753, 0.678, 1.3%, 0.652, 0.625; Cit, Arg, Pro, Tyr, Lys, Ile, 0.753, 0.708, 3.1%, 0.711, 0.746; Gln, Ala, Arg, Met, Lys, Ile, 0.753, 0.685, 1.1%, 0.687, 0.724; Gln, Ala, Arg, Tyr, Lys, Ile, 0.753, 0.722, 4.0%, 0.729, 0.773; Gln, Arg, Tyr, Leu, Phe, Trp, 0.753, 0.734, 2.4%, 0.732, 0.684; Gln, Arg, Tyr, Met, Leu, Phe, 0.753, 0.733, 1.8%, 0.738, 0.688; Gln, Cit, Lys, Ile, Leu, Phe, 0.753, 0.686, 0.6%, 0.671, 0.669; Gln, Cit, Orn, Lys, Ile, Trp, 0.753, 0.675, 2.2%, 0.663, 0.704; Gln, Cit, Pro, Orn, Ile, Trp, 0.753, 0.682, 1.8%, 0.688, 0.679; Gln, Cit, Tyr, Val, Orn, Ile, 0.753, 0.713, 3.9%, 0.725, 0.740; Gln, His, Ala, Arg, Ile, Leu, 0.753, 0.706, 0.9%, 0.731, 0.720; Gln, His, Ala, Pro, Val, Ile, 0.753, 0.707, 1.1%, 0.728, 0.734; Gln, His, Arg, Lys, Ile, Leu, 0.753, 0.697, 1.1%, 0.710, 0.742; Gln, His, Arg, Met, Ile, Trp, 0.753, 0.711, 1.1%, 0.730, 0.702; Gln, His, Arg, Pro, Ile, Leu, 0.753, 0.708, 1.1%, 0.733, 0.720; Gln, His, Met, Ile, Leu, Trp, 0.753, 0.708, 1.1%, 0.723, 0.704; Gln, His, Pro, Met, Ile, Leu, 0.753, 0.709, 1.1%, 0.726, 0.714; Gln, His, Pro, Tyr, Lys, Leu, 0.753, 0.721, 3.5%, 0.719, 0.748; Gln, His, Thr, Arg, Orn, Ile, 0.753, 0.695, 0.9%, 0.718, 0.710; Gln, His, Thr, Val, Ile, Phe, 0.753, 0.700, 0.4%, 0.722, 0.694; Gln, His, Tyr, Val, Orn, Leu, 0.753, 0.723, 1.5%, 0.725, 0.742; Gln, Pro, Tyr, Lys, Ile, Trp, 0.753, 0.724, 7.0%, 0.712, 0.750; Gln, Pro, Tyr, Lys, Leu, Trp, 0.753, 0.725, 5.5%, 0.707, 0.728; Gln, Thr, Cit, Tyr, Orn, Ile, 0.753, 0.710, 3.3%, 0.729, 0.742; Gln, Thr, Lys, Ile, Leu, Trp, 0.753, 0.686, 0.7%, 0.658, 0.696; Gln, Val, Orn, Lys, Ile, Phe, 0.753, 0.674, 0.9%, 0.652, 0.671; Gly, Ala, Arg, Lys, Ile, Phe, 0.753, 0.666, 0.6%, 0.660, 0.665; Gly, Arg, Orn, Lys, Ile, Phe, 0.753, 0.667, 0.9%, 0.655, 0.653; Gly, Cit, Tyr, Met, Orn, Ile, 0.753, 0.710, 7.2%, 0.705, 0.708; Gly, Cit, Tyr, Val, Ile, Trp, 0.753, 0.721, 6.4%, 0.704, 0.716; Gly, Gln, Ala, Cit, Lys, Ile, 0.753, 0.678, 0.7%, 0.664, 0.716; Gly, Gln, Cit, Lys, Ile, Trp, 0.753, 0.679, 0.7%, 0.660, 0.702; Gly, Gln, His, Ala, Cit, Ile, 0.753, 0.702, 1.3%, 0.720, 0.712; Gly, Gln, His, Arg, Tyr, Val, 0.753, 0.733, 1.8%, 0.731, 0.734; Gly, Gln, His, Lys, Ile, Leu, 0.753, 0.694, 1.7%, 0.689, 0.728; Gly, Gln, His, Met, Orn, Ile, 0.753, 0.693, 0.7%, 0.709, 0.688; Gly, Gln, 

His, Orn, Lys, Ile, 0.753, 0.692, 1.5%, 0.685, 0.700; Gly, Gln, His, Thr, Ile, Phe, 0.753, 0.696, 0.2%, 0.715, 0.680; Gly, Gln, His, Tyr, Val, Lys, 0.753, 0.727, 4.6%, 0.717, 0.750; Gly, Gln, Orn, Lys, Ile, Trp, 0.753, 0.676, 0.7%, 0.645, 0.688; Gly, Gln, Pro, Tyr, Lys, Leu, 0.753, 0.719, 3.5%, 0.699, 0.712; Gly, Gln, Thr, Tyr, Val, Ile, 0.753, 0.727, 7.9%, 0.721, 0.716; Gly, Gln, Tyr, Val, Lys, Phe, 0.753, 0.728, 5.0%, 0.706, 0.692; His, Thr, Tyr, Ile, Leu, Phe, 0.753, 0.723, 3.3%, 0.725, 0.669; His, Thr, Tyr, Met, Lys, Ile, 0.753, 0.722, 7.4%, 0.710, 0.708; Ser, Asn, Arg, Tyr, Lys, Leu, 0.753, 0.719, 3.3%, 0.710, 0.690; Ser, Asn, Gln, His, Lys, Leu, 0.753, 0.687, 0.2%, 0.667, 0.657; Ser, Asn, Gly, Gln, Lys, Ile, 0.753, 0.662, 2.9%, 0.636, 0.669; Ser, Asn, Thr, Tyr, Lys, Ile, 0.753, 0.700, 9.4%, 0.682, 0.696; Ser, Asn, Tyr, Ile, Leu, Phe, 0.753, 0.722, 3.1%, 0.714, 0.663; Ser, Cit, Tyr, Lys, Ile, Trp, 0.753, 0.706, 6.2%, 0.690, 0.744; Ser, Gln, Ala, Lys, Leu, Phe, 0.753, 0.671, 0.4%, 0.654, 0.641; Ser, Gln, His, Ile, Leu, Phe, 0.753, 0.690, 0.4%, 0.704, 0.679; Ser, Gln, His, Thr, Arg, Ile, 0.753, 0.693, 0.6%, 0.709, 0.744; Ser, Gln, Pro, Tyr, Leu, Trp, 0.753, 0.723, 5.1%, 0.711, 0.710; Ser, Gln, Tyr, Met, Ile, Trp, 0.753, 0.717, 7.4%, 0.716, 0.744; Ser, Gln, Val, Lys, Ile, Trp, 0.753, 0.660, 1.5%, 0.632, 0.712; Ser, Gly, Gln, Lys, Ile, Phe, 0.753, 0.662, 1.3%, 0.633, 0.657; Ser, Gly, Gln, Tyr, Orn, Ile, 0.753, 0.720, 5.3%, 0.719, 0.742; Ser, Gly, Gln, Val, Lys, Ile, 0.753, 0.657, 1.7%, 0.632, 0.708; Ser, His, Arg, Lys, Ile, Phe, 0.753, 0.668, 0.4%, 0.651, 0.655; Ser, His, Cit, Tyr, Met, Ile, 0.753, 0.721, 3.5%, 0.724, 0.730; Thr, Tyr, Orn, Ile, Leu, Phe, 0.753, 0.724, 3.3%, 0.719, 0.675; Asn, Ala, Cit, Val, Lys, Ile, 0.752, 0.678, 1.7%, 0.667, 0.692; Asn, Arg, Tyr, Ile, Leu, Phe, 0.752, 0.723, 2.4%, 0.720, 0.659; Asn, Arg, Tyr, Orn, Leu, Phe, 0.752, 0.714, 1.7%, 0.713, 0.649; Asn, Arg, Val, Met, Lys, Ile, 0.752, 0.670, 2.4%, 0.661, 0.686; Asn, Cit, Arg, Pro, Lys, Ile, 0.752, 0.674, 2.4%, 0.664, 0.677; Asn, Cit, Arg, Tyr, Ile, Phe, 0.752, 0.728, 3.7%, 0.738, 0.692; Asn, Cit, Tyr, Met, Leu, Phe, 0.752, 0.728, 1.7%, 0.721, 0.651; Asn, Cit, Tyr, Met, Orn, Ile, 0.752, 0.715, 6.1%, 0.722, 0.714; Asn, Cit, Tyr, Orn, Lys, Leu, 0.752, 0.704, 2.8%, 0.694, 0.671; Asn, Gln, Arg, Lys, Leu, Phe, 0.752, 0.674, 0.0%, 0.645, 0.609; Asn, Gln, Arg, Tyr, Leu, Trp, 0.752, 0.731, 4.4%, 0.724, 0.700; Asn, Gln, Cit, Tyr, Met, Leu, 0.752, 0.733, 3.1%, 0.735, 0.716; Asn, Gln, His, Ala, Lys, Leu, 0.752, 0.686, 2.4%, 0.675, 0.649; Asn, Gln, His, Ala, Orn, Lys, 0.752, 0.674, 1.5%, 0.671, 0.702; Asn, Gln, His, Pro, Lys, Ile, 0.752, 0.693, 2.4%, 0.685, 0.673; Asn, Gln, His, Tyr, Lys, Phe, 0.752, 0.737, 3.3%, 0.740, 0.759; Asn, Gln, Met, Lys, Ile, Leu, 0.752, 0.682, 1.7%, 0.660, 0.673; Asn, Gln, Orn, Lys, Ile, Leu, 0.752, 0.677, 2.0%, 0.653, 0.663; Asn, Gln, Thr, Cit, Tyr, Leu, 0.752, 0.733, 2.8%, 0.735, 0.710; Asn, Gln, Thr, Tyr, Lys, Leu, 0.752, 0.727, 3.5%, 0.714, 0.704; Asn, Gln, Tyr, Met, Orn, Leu, 0.752, 0.723, 4.0%, 0.718, 0.684; Asn, Gln, Tyr, Val, Leu, Trp, 0.752, 0.732, 5.1%, 0.720, 0.698; Asn, Gly, Ala, Tyr, Lys, Leu, 0.752, 0.712, 2.6%, 0.685, 0.653; Asn, Gly, Arg, Pro, Tyr, Ile, 0.752, 0.724, 5.7%, 0.723, 0.696; Asn, Gly, Gln, Arg, Orn, Leu, 0.752, 0.676, 0.2%, 0.662, 0.596; Asn, Gly, Gln, Pro, Lys, Ile, 0.752, 0.672, 2.4%, 0.645, 0.649; Asn, Gly, His, Met, Ile, Phe, 0.752, 0.690, 0.7%, 0.690, 0.609; Asn, Gly, His, Tyr, Lys, Leu, 0.752, 0.712, 3.5%, 0.686, 0.653; Asn, His, Ala, Pro, Tyr, Ile, 0.752, 0.725, 3.9%, 0.732, 0.706; Asn, His, Arg, Pro, Tyr, Lys, 0.752, 0.711, 4.8%, 0.705, 0.757; Asn, His, Cit, Val, Orn, Lys, 0.752, 0.682, 0.2%, 0.669, 0.633; Asn, His, Met, Orn, Lys, Ile, 0.752, 0.683, 3.9%, 0.662, 0.627; Asn, His, Pro, Lys, Ile, Phe, 0.752, 0.682, 2.2%, 0.663, 0.621; Asn, His, Thr, Arg, Ile, Phe, 0.752, 0.692, 0.2%, 0.695, 0.629; Asn, His, Thr, Met, Ile, Phe, 0.752, 0.691, 0.7%, 0.692, 0.609; Asn, His, Thr, Orn, Ile, Phe, 0.752, 0.684, 0.7%, 0.690, 0.611; Asn, His, Tyr, Val, Ile, Trp, 0.752, 0.728, 6.8%, 0.724, 0.690; Asn, Pro, Tyr, Ile, Leu, Phe, 0.752, 0.723, 3.3%, 0.715, 0.661; Asn, Thr, Cit, Tyr, Ile, Phe, 0.752, 0.728, 4.2%, 0.736, 0.690; Asn, Thr, Cit, Tyr, Val, Ile, 0.752, 0.732, 5.3%, 0.739, 0.710; Asn, Thr, Tyr, Met, Lys, Leu, 0.752, 0.719, 3.9%, 0.698, 0.671; Asn, Tyr, Val, Ile, Leu, Phe, 0.752, 0.721, 2.6%, 0.716, 0.651; Cit, Arg, Tyr, Orn, Leu, Trp, 0.752, 0.701, 5.0%, 0.693, 0.665; Cit, Tyr, Met, Ile, Leu, Phe, 0.752, 0.719, 3.1%, 0.715, 0.671; Gln, Ala, Arg, Lys, Ile, Leu, 0.752, 0.684, 1.1%, 0.685, 0.724; Gln, Ala, Arg, Val, Lys, Ile, 0.752, 0.680, 0.9%, 0.685, 0.740; Gln, Arg, Tyr, Met, Ile, Phe, 0.752, 0.724, 3.9%, 0.741, 0.712; Gln, Cit, Arg, Met, Lys, Ile, 0.752, 0.687, 1.1%, 0.688, 0.734; Gln, Cit, Tyr, Met, Lys, Ile, 0.752, 0.722, 3.7%, 0.725, 0.763; Gln, Cit, Tyr, Val, Ile, Phe, 0.752, 0.730, 3.1%, 0.742, 0.712; Gln, His, Arg, Met, Orn, Ile, 0.752, 0.696, 0.9%, 0.717, 0.698; Gln, His, Arg, Tyr, Orn, Lys, 0.752, 0.713, 1.1%, 0.731, 0.785; Gln, His, Arg, Val, Ile, Leu, 0.752, 0.709, 0.6%, 0.733, 0.720; Gln, His, Met, Orn, Leu, Phe, 0.752, 0.687, 0.0%, 0.678, 0.629; Gln, His, Pro, Met, Ile, Trp, 0.752, 0.710, 1.3%, 0.726, 0.708; Gln, His, Thr, Ala, Arg, Ile, 0.752, 0.706, 0.7%, 0.734, 0.730; Gln, His, Thr, Arg, Ile, Trp, 0.752, 0.702, 1.3%, 0.726, 0.722; Gln, His, Thr, Arg, Met, Ile, 0.752, 0.708, 0.4%, 0.729, 0.718; Gln, His, Thr, Met, Ile, Leu, 0.752, 0.709, 0.4%, 0.727, 0.722; Gln, His, Thr, Pro, Ile, Leu, 0.752, 0.709, 1.3%, 0.727, 0.728; Gln, His, Thr, Pro, Ile, Phe, 0.752, 0.700, 0.4%, 0.718, 0.682; Gln, His, Tyr, Val, Met, Leu, 0.752, 0.735, 2.0%, 0.734, 0.716; Gln, Pro, Tyr, Orn, Leu, Trp, 0.752, 0.721, 4.2%, 0.710, 0.708; Gln, Thr, Arg, Tyr, Leu, Phe, 0.752, 0.733, 1.8%, 0.739, 0.690; Gln, Thr, Pro, Tyr, Ile, Leu, 0.752, 0.730, 4.6%, 0.733, 0.736; Gln, Tyr, Met, Orn, Leu, Trp, 0.752, 0.723, 4.8%, 0.714, 0.706; Gln, Tyr, Val, Orn, Leu, Trp, 0.752, 0.721, 5.1%, 0.707, 0.708; Gln, Val, Lys, Ile, Phe, Trp, 0.752, 0.674, 0.7%, 0.653, 0.671; Gly, Ala, Cit, Tyr, Val, Ile, 0.752, 0.717, 5.3%, 0.704, 0.720; Gly, Arg, Lys, Ile, Leu, Phe, 0.752, 0.672, 0.7%, 0.652, 0.643; Gly, Gln, Ala, Cit, Orn, Ile, 0.752, 0.677, 1.5%, 0.679, 0.675; Gly, Gln, Arg, Tyr, Ile, Trp, 0.752, 0.726, 7.4%, 0.730, 0.736; Gly, Gln, Cit, Val, Orn, Ile, 0.752, 0.679, 2.4%, 0.677, 0.659; Gly, Gln, His, Lys, Leu, Phe, 0.752, 0.689, 0.0%, 0.667, 0.639; Gly, Gln, His, Pro, Ile, Phe, 0.752, 0.696, 0.2%, 0.714, 0.671; Gly, Gln, His, Thr, Tyr, Leu, 0.752, 0.726, 2.8%, 0.724, 0.722; Gly, Gln, Orn, Lys, Leu, Phe, 0.752, 0.669, 0.2%, 0.634, 0.602; Gly, Gln, Thr, Cit, Tyr, Leu, 0.752, 0.718, 3.7%, 0.711, 0.692; Gly, Gln, Thr, Lys, Ile, Trp, 0.752, 0.677, 0.7%, 0.645, 0.688; Gly, Gln, Thr, Tyr, Val, Leu, 0.752, 0.723, 6.8%, 0.713, 0.700; Gly, Gln, Tyr, Met, Orn, Ile, 0.752, 0.733, 6.2%, 0.727, 0.722; Gly, His, Thr, Tyr, Met, Ile, 0.752, 0.725, 5.3%, 0.722, 0.698; Gly, His, Tyr, Ile, Phe, Trp, 0.752, 0.707, 4.2%, 0.700, 0.667; Gly, His, Tyr, Lys, Ile, Phe, 0.752, 0.703, 4.0%, 0.690, 0.680; Gly, His, Tyr, Met, Orn, Ile, 0.752, 0.726, 3.5%, 0.720, 0.702; His, Cit, Tyr, Met, Ile, Trp, 0.752, 0.726, 4.0%, 0.732, 0.728; His, Tyr, Lys, Ile, Phe, Trp, 0.752, 0.704, 4.4%, 0.685, 0.677; Ser, Ala, Arg, Lys, Ile, Phe, 0.752, 0.654, 1.3%, 0.647, 0.682; Ser, Asn, Cit, Pro, Tyr, Ile, 0.752, 0.722, 4.6%, 0.728, 0.722; Ser, Asn, Cit, Tyr, Leu, Phe, 0.752, 0.728, 1.5%, 0.721, 0.645; Ser, Asn, Gln, Arg, Tyr, Ile, 0.752, 0.716, 5.0%, 0.727, 0.740; Ser, Asn, Gln, Met, Lys, Ile, 0.752, 0.661, 2.9%, 0.637, 0.682; Ser, Asn, His, Tyr, Ile, Trp, 0.752, 0.715, 4.2%, 0.717, 0.700; Ser, Gln, Cit, Lys, Ile, Phe, 0.752, 0.666, 1.3%, 0.647, 0.682; Ser, Gln, His, Tyr, Met, Leu, 0.752, 0.736, 2.0%, 0.737, 0.724; Ser, Gln, His, Tyr, Val, Trp, 0.752, 0.736, 4.4%, 0.727, 0.734; Ser, Gln, Thr, Lys, Ile, Trp, 0.752, 0.663, 1.7%, 0.635, 0.698; Ser, Gln, Tyr, Lys, Leu, Phe, 0.752, 0.727, 2.0%, 0.723, 0.694; Ser, Gln, Val, Lys, Ile, Phe, 0.752, 0.653, 1.5%, 0.631, 0.679; Ser, Gly, Gln, Arg, Tyr, Ile, 0.752, 0.715, 5.3%, 0.723, 0.738; Ser, Gly, Gln, Tyr, Lys, Leu, 0.752, 0.724, 3.9%, 0.707, 0.720; Ser, His, Tyr, Ile, Phe, Trp, 0.752, 0.710, 4.2%, 0.705, 0.671; Ser, Thr, Arg, Lys, Ile, Phe, 0.752, 0.657, 1.3%, 0.639, 0.661; Thr, Arg, Orn, Lys, Ile, Phe, 0.752, 0.669, 0.9%, 0.659, 0.661; Thr, Pro, Tyr, Ile, Leu, Phe, 0.752, 0.723, 3.7%, 0.718, 0.663; Ala, Arg, Lys, Ile, Phe, Trp, 0.752, 0.666, 0.7%, 0.659, 0.671; Ala, Arg, Met, Lys, Ile, Phe, 0.752, 0.669, 0.6%, 0.663, 0.677; Ala, Arg, Tyr, Lys, Ile, Leu, 0.752, 0.708, 3.1%, 0.703, 0.736; Ala, Arg, Val, Lys, Ile, Phe, 0.752, 0.666, 0.7%, 0.661, 0.675; Asn, Ala, Arg, Tyr, Lys, Leu, 0.752, 0.714, 2.4%, 0.704, 0.692; Asn, Ala, Arg, Val, Lys, Ile, 0.752, 0.667, 3.5%, 0.662, 0.688; Asn, Ala, Cit, Tyr, Met, Ile, 0.752, 0.733, 5.1%, 0.736, 0.704; Asn, Arg, Pro, Orn, Lys, Ile, 0.752, 0.664, 3.3%, 0.657, 0.659; Asn, Arg, Pro, Tyr, Lys, Leu, 0.752, 0.711, 3.9%, 0.703, 0.679; Asn, Arg, Pro, Tyr, Lys, Phe, 0.752, 0.699, 6.8%, 0.678, 0.706; Asn, Arg, Tyr, Val, Leu, Phe, 0.752, 0.728, 1.5%, 0.722, 0.641; Asn, Arg, Tyr, Val, Lys, Trp, 0.752, 0.728, 6.4%, 0.710, 0.716; Asn, Cit, Arg, Tyr, Lys, Leu, 0.752, 0.719, 2.9%, 0.710, 0.694; Asn, Cit, Arg, Tyr, Orn, Ile, 0.752, 0.712, 4.0%, 0.727, 0.720; Asn, Cit, Met, Lys, Ile, Phe, 0.752, 0.681, 2.0%, 0.660, 0.665; Asn, Cit, Tyr, Met, Lys, Leu, 0.752, 0.721, 2.4%, 0.698, 0.669; Asn, Cit, Tyr, Orn, Ile, Leu, 0.752, 0.710, 3.1%, 0.715, 0.692; Asn, Cit, Tyr, Val, Orn, Ile, 0.752, 0.716, 4.4%, 0.720, 0.706; Asn, Cit, Val, Lys, Ile, Phe, 0.752, 0.680, 1.8%, 0.661, 0.665; Asn, Gln, Cit, Tyr, Met, Ile, 0.752, 0.729, 3.7%, 0.743, 0.740; Asn, Gln, Cit, Val, Lys, Leu, 0.752, 0.680, 0.2%, 0.652, 0.625; Asn, Gln, His, Arg, Tyr, Leu, 0.752, 0.732, 1.3%, 0.740, 0.716; Asn, Gln, Orn, Lys, Leu, Trp, 0.752, 0.670, 0.2%, 0.643, 0.613; Asn, Gln, Pro, Lys, Leu, Phe, 0.752, 0.676, 0.4%, 0.654, 0.615; Asn, Gln, Thr, Lys, Leu, Trp, 0.752, 0.681, 0.2%, 0.654, 0.627; Asn, Gln, Tyr, Met, Leu, Trp, 0.752, 0.735, 5.0%, 0.725, 0.698; Asn, Gln, Val, Met, Lys, Ile, 0.752, 0.675, 2.4%, 0.655, 0.686; Asn, Gly, Cit, Arg, Tyr, Leu, 0.752, 0.720, 3.1%, 0.708, 0.653; Asn, Gly, G

ln, Orn, Leu, Trp, 0.752, 0.675, 0.2%, 0.657, 0.590; Asn, Gly, His, Ala, Tyr, Ile, 0.752, 0.719, 5.1%, 0.718, 0.688; Asn, Gly, His, Tyr, Lys, Ile, 0.752, 0.709, 6.6%, 0.698, 0.692; Asn, Gly, Thr, Tyr, Ile, Leu, 0.752, 0.719, 8.5%, 0.704, 0.655; Asn, Gly, Tyr, Orn, Ile, Leu, 0.752, 0.725, 5.5%, 0.706, 0.669; Asn, His, Arg, Lys, Ile, Leu, 0.752, 0.682, 1.8%, 0.684, 0.692; Asn, His, Arg, Met, Lys, Ile, 0.752, 0.683, 1.8%, 0.682, 0.673; Asn, His, Arg, Tyr, Lys, Leu, 0.752, 0.720, 3.5%, 0.712, 0.696; Asn, His, Cit, Arg, Orn, Ile, 0.752, 0.689, 1.5%, 0.699, 0.651; Asn, His, Cit, Orn, Ile, Phe, 0.752, 0.681, 0.9%, 0.685, 0.623; Asn, His, Cit, Tyr, Leu, Phe, 0.752, 0.727, 1.7%, 0.723, 0.657; Asn, His, Tyr, Ile, Leu, Phe, 0.752, 0.723, 2.9%, 0.723, 0.659; Asn, His, Tyr, Val, Ile, Phe, 0.752, 0.722, 3.5%, 0.724, 0.665; Asn, Thr, Ala, Cit, Lys, Ile, 0.752, 0.676, 1.7%, 0.665, 0.692; Asn, Thr, Orn, Lys, Ile, Leu, 0.752, 0.678, 1.7%, 0.653, 0.657; Asn, Tyr, Met, Lys, Leu, Trp, 0.752, 0.724, 3.9%, 0.696, 0.659; Asn, Tyr, Met, Orn, Leu, Phe, 0.752, 0.723, 2.8%, 0.713, 0.639; Cit, Arg, Tyr, Orn, Ile, Trp, 0.752, 0.705, 5.5%, 0.716, 0.716; Cit, Tyr, Ile, Leu, Phe, Trp, 0.752, 0.718, 3.7%, 0.714, 0.673; Gln, Ala, Cit, Arg, Lys, Ile, 0.752, 0.683, 1.8%, 0.687, 0.732; Gln, Ala, Tyr, Val, Lys, Trp, 0.752, 0.728, 6.6%, 0.705, 0.726; Gln, Ala, Val, Lys, Ile, Trp, 0.752, 0.679, 1.1%, 0.662, 0.712; Gln, Arg, Tyr, Val, Leu, Phe, 0.752, 0.732, 1.5%, 0.736, 0.694; Gln, Arg, Tyr, Val, Lys, Trp, 0.752, 0.731, 4.6%, 0.714, 0.738; Gln, Cit, Pro, Tyr, Lys, Ile, 0.752, 0.718, 3.7%, 0.727, 0.789; Gln, Cit, Tyr, Met, Ile, Leu, 0.752, 0.730, 2.4%, 0.737, 0.728; Gln, Cit, Tyr, Met, Lys, Leu, 0.752, 0.726, 2.2%, 0.716, 0.718; Gln, Cit, Tyr, Val, Lys, Ile, 0.752, 0.717, 3.3%, 0.725, 0.793; Gln, Cit, Val, Lys, Ile, Phe, 0.752, 0.677, 1.1%, 0.667, 0.673; Gln, His, Ala, Tyr, Leu, Phe, 0.752, 0.727, 1.8%, 0.733, 0.702; Gln, His, Ala, Tyr, Orn, Leu, 0.752, 0.720, 2.0%, 0.727, 0.757; Gln, His, Arg, Orn, Leu, Phe, 0.752, 0.687, 0.0%, 0.683, 0.621; Gln, His, Arg, Pro, Ile, Trp, 0.752, 0.708, 1.5%, 0.727, 0.706; Gln, His, Arg, Val, Ile, Trp, 0.752, 0.709, 1.1%, 0.728, 0.702; Gln, His, Cit, Tyr, Leu, Trp, 0.752, 0.735, 3.3%, 0.732, 0.732; Gln, His, Lys, Ile, Leu, Trp, 0.752, 0.700, 1.3%, 0.696, 0.712; Gln, His, Orn, Leu, Phe, Trp, 0.752, 0.687, 0.0%, 0.678, 0.621; Gln, His, Tyr, Met, Orn, Leu, 0.752, 0.722, 2.0%, 0.728, 0.706; Gln, Orn, Ile, Leu, Phe, Trp, 0.752, 0.686, 0.2%, 0.685, 0.637; Gln, Thr, Cit, Val, Ile, Leu, 0.752, 0.698, 0.2%, 0.705, 0.690; Gln, Thr, Lys, Ile, Phe, Trp, 0.752, 0.679, 0.7%, 0.653, 0.665; Gln, Thr, Orn, Lys, Ile, Phe, 0.752, 0.678, 0.7%, 0.652, 0.661; Gln, Thr, Orn, Lys, Ile, Trp, 0.752, 0.681, 0.9%, 0.656, 0.708; Gln, Thr, Tyr, Orn, Ile, Leu, 0.752, 0.724, 4.6%, 0.729, 0.738; Gln, Thr, Tyr, Val, Ile, Leu, 0.752, 0.729, 4.6%, 0.732, 0.734; Gln, Tyr, Met, Orn, Lys, Leu, 0.752, 0.720, 2.8%, 0.705, 0.698; Gln, Tyr, Val, Lys, Ile, Leu, 0.752, 0.716, 4.4%, 0.715, 0.750; Gln, Tyr, Val, Met, Ile, Trp, 0.752, 0.737, 7.4%, 0.729, 0.718; Gln, Tyr, Val, Orn, Lys, Trp, 0.752, 0.727, 6.2%, 0.704, 0.722; Gly, Arg, Tyr, Lys, Leu, Phe, 0.752, 0.712, 1.5%, 0.693, 0.639; Gly, Arg, Val, Lys, Ile, Phe, 0.752, 0.671, 0.9%, 0.658, 0.669; Gly, Cit, Arg, Tyr, Ile, Phe, 0.752, 0.714, 3.9%, 0.715, 0.692; Gly, Cit, Pro, Tyr, Val, Ile, 0.752, 0.714, 5.1%, 0.705, 0.722; Gly, Cit, Tyr, Ile, Phe, Trp, 0.752, 0.709, 5.3%, 0.707, 0.700; Gly, Cit, Tyr, Met, Lys, Ile, 0.752, 0.708, 5.0%, 0.693, 0.714; Gly, Cit, Tyr, Orn, Ile, Phe, 0.752, 0.704, 5.0%, 0.706, 0.696; Gly, Gln, Ala, Cit, Arg, Ile, 0.752, 0.688, 1.1%, 0.695, 0.688; Gly, Gln, Ala, Cit, Ile, Trp, 0.752, 0.687, 1.1%, 0.694, 0.690; Gly, Gln, Arg, Tyr, Orn, Ile, 0.752, 0.727, 5.9%, 0.731, 0.728; Gly, Gln, Cit, Tyr, Val, Leu, 0.752, 0.719, 2.4%, 0.710, 0.714; Gly, Gln, His, Thr, Met, Ile, 0.752, 0.702, 0.7%, 0.715, 0.718; Gly, Gln, His, Val, Met, Ile, 0.752, 0.702, 0.9%, 0.715, 0.710; Gly, Gln, Pro, Tyr, Met, Leu, 0.752, 0.722, 2.9%, 0.710, 0.680; Gly, Gln, Thr, Tyr, Orn, Ile, 0.752, 0.725, 7.0%, 0.727, 0.732; Gly, Gln, Thr, Tyr, Val, Phe, 0.752, 0.733, 7.5%, 0.715, 0.669; Gly, Gln, Tyr, Orn, Ile, Phe, 0.752, 0.726, 5.3%, 0.728, 0.704; Gly, Gln, Tyr, Val, Ile, Trp, 0.752, 0.727, 8.1%, 0.717, 0.720; Gly, His, Pro, Tyr, Ile, Phe, 0.752, 0.708, 3.5%, 0.701, 0.684; Gly, Thr, Tyr, Ile, Leu, Phe, 0.752, 0.719, 4.4%, 0.705, 0.647; His, Ala, Tyr, Orn, Ile, Phe, 0.752, 0.717, 3.1%, 0.714, 0.694; His, Arg, Lys, Ile, Phe, Trp, 0.752, 0.679, 0.4%, 0.660, 0.647; His, Cit, Pro, Tyr, Met, Ile, 0.752, 0.724, 3.5%, 0.726, 0.720; His, Thr, Cit, Tyr, Met, Ile, 0.752, 0.726, 3.7%, 0.730, 0.730; His, Thr, Tyr, Val, Ile, Phe, 0.752, 0.727, 3.7%, 0.725, 0.680; His, Tyr, Ile, Leu, Phe, Trp, 0.752, 0.714, 3.7%, 0.698, 0.641; His, Tyr, Orn, Ile, Phe, Trp, 0.752, 0.719, 3.7%, 0.715, 0.684; His, Tyr, Val, Ile, Phe, Trp, 0.752, 0.720, 5.1%, 0.706, 0.665; Ser, Arg, Tyr, Lys, Leu, Phe, 0.752, 0.724, 1.3%, 0.716, 0.667; Ser, Asn, Ala, Cit, Tyr, Ile, 0.752, 0.721, 4.6%, 0.727, 0.722; Ser, Asn, Cit, Arg, Tyr, Ile, 0.752, 0.723, 4.4%, 0.733, 0.726; Ser, Asn, Gln, Arg, Lys, Leu, 0.752, 0.667, 0.4%, 0.641, 0.645; Ser, Asn, Gln, Pro, Lys, Ile, 0.752, 0.660, 2.8%, 0.635, 0.675; Ser, Asn, Gln, Thr, Lys, Leu, 0.752, 0.674, 0.2%, 0.644, 0.627; Ser, Asn, His, Arg, Ile, Phe, 0.752, 0.672, 0.7%, 0.677, 0.637; Ser, Asn, His, Tyr, Orn, Ile, 0.752, 0.723, 4.6%, 0.727, 0.714; Ser, Cit, Tyr, Ile, Leu, Phe, 0.752, 0.713, 3.1%, 0.714, 0.671; Ser, Gln, His, Ala, Arg, Ile, 0.752, 0.688, 0.6%, 0.705, 0.736; Ser, Gln, His, Ala, Ile, Phe, 0.752, 0.684, 0.4%, 0.703, 0.688; Ser, Gln, His, Lys, Ile, Phe, 0.752, 0.684, 0.4%, 0.675, 0.665; Ser, Gln, His, Met, Ile, Phe, 0.752, 0.689, 0.4%, 0.707, 0.684; Ser, Gln, His, Pro, Ile, Phe, 0.752, 0.685, 0.4%, 0.704, 0.679; Ser, Gln, His, Thr, Cit, Ile, 0.752, 0.692, 1.1%, 0.707, 0.736; Ser, Gln, Lys, Ile, Leu, Phe, 0.752, 0.663, 1.1%, 0.637, 0.653; Ser, Gln, Lys, Ile, Leu, Trp, 0.752, 0.664, 1.3%, 0.634, 0.688; Ser, Gln, Tyr, Lys, Leu, Trp, 0.752, 0.724, 4.0%, 0.703, 0.736; Ser, Gln, Tyr, Met, Ile, Leu, 0.752, 0.719, 3.3%, 0.719, 0.710; Ser, Gln, Tyr, Val, Leu, Phe, 0.752, 0.729, 1.8%, 0.728, 0.677; Ser, Gln, Val, Met, Lys, Ile, 0.752, 0.659, 1.5%, 0.637, 0.728; Ser, Gly, Gln, His, Arg, Ile, 0.752, 0.692, 0.6%, 0.706, 0.724; Ser, Gly, Gln, His, Tyr, Val, 0.752, 0.738, 4.0%, 0.730, 0.732; Ser, Gly, Gln, Lys, Ile, Trp, 0.752, 0.663, 1.7%, 0.631, 0.688; Ser, His, Ala, Tyr, Met, Ile, 0.752, 0.721, 5.5%, 0.722, 0.712; Ser, His, Tyr, Orn, Ile, Phe, 0.752, 0.720, 2.9%, 0.715, 0.686; Ser, Thr, Tyr, Ile, Leu, Phe, 0.752, 0.722, 3.3%, 0.717, 0.677; Thr, Ala, Arg, Lys, Ile, Phe, 0.752, 0.667, 0.6%, 0.661, 0.677; Thr, Arg, Met, Lys, Ile, Phe, 0.752, 0.675, 0.7%, 0.662, 0.675; Thr, Pro, Tyr, Lys, Ile, Phe, 0.752, 0.715, 5.9%, 0.704, 0.688; Thr, Pro, Tyr, Met, Leu, Phe, 0.752, 0.721, 3.7%, 0.716, 0.647; Thr, Tyr, Val, Ile, Leu, Phe, 0.752, 0.725, 3.7%, 0.717, 0.671; Ala, Cit, Tyr, Ile, Leu, Phe, 0.751, 0.712, 3.3%, 0.717, 0.688; Arg, Pro, Tyr, Met, Orn, Lys, 0.751, 0.684, 10.1%, 0.670, 0.738; Asn, Ala, Arg, Lys, Ile, Trp, 0.751, 0.671, 3.5%, 0.668, 0.696; Asn, Ala, Cit, Arg, Lys, Ile, 0.751, 0.672, 3.1%, 0.667, 0.694; Asn, Arg, Tyr, Val, Lys, Leu, 0.751, 0.719, 3.3%, 0.709, 0.692; Asn, Cit, Arg, Tyr, Met, Ile, 0.751, 0.733, 5.3%, 0.739, 0.704; Asn, Gln, Ala, Orn, Lys, Leu, 0.751, 0.670, 0.7%, 0.646, 0.621; Asn, Gln, Ala, Tyr, Ile, Trp, 0.751, 0.732, 7.2%, 0.737, 0.726; Asn, Gln, Arg, Orn, Lys, Leu, 0.751, 0.669, 0.2%, 0.653, 0.621; Asn, Gln, Cit, Tyr, Ile, Trp, 0.751, 0.735, 5.5%, 0.746, 0.750; Asn, Gln, Cit, Tyr, Val, Leu, 0.751, 0.730, 2.0%, 0.731, 0.714; Asn, Gln, His, Cit, Orn, Leu, 0.751, 0.689, 0.9%, 0.690, 0.633; Asn, Gln, Pro, Tyr, Leu, Trp, 0.751, 0.731, 5.1%, 0.722, 0.698; Asn, Gln, Thr, Cit, Lys, Ile, 0.751, 0.685, 1.5%, 0.672, 0.692; Asn, Gln, Thr, Cit, Tyr, Ile, 0.751, 0.728, 3.3%, 0.746, 0.750; Asn, Gln, Thr, Lys, Ile, Trp, 0.751, 0.679, 1.5%, 0.656, 0.680; Asn, Gly, Ala, Pro, Tyr, Leu, 0.751, 0.713, 2.4%, 0.695, 0.647; Asn, Gly, Ala, Tyr, Val, Leu, 0.751, 0.713, 2.4%, 0.696, 0.647; Asn, Gly, Gln, Ala, Cit, Ile, 0.751, 0.686, 1.3%, 0.696, 0.679; Asn, Gly, Gln, Ile, Leu, Phe, 0.751, 0.686, 0.2%, 0.686, 0.627; Asn, Gly, Gln, Val, Orn, Leu, 0.751, 0.674, 0.2%, 0.656, 0.590; Asn, Gly, His, Tyr, Ile, Trp, 0.751, 0.717, 4.4%, 0.716, 0.700; Asn, Gly, Thr, Arg, Tyr, Ile, 0.751, 0.723, 5.9%, 0.723, 0.686; Asn, Gly, Thr, Orn, Lys, Ile, 0.751, 0.677, 2.0%, 0.650, 0.659; Asn, His, Ala, Cit, Ile, Leu, 0.751, 0.701, 1.5%, 0.710, 0.665; Asn, His, Ala, Lys, Ile, Phe, 0.751, 0.680, 1.7%, 0.666, 0.671; Asn, His, Arg, Met, Ile, Phe, 0.751, 0.692, 0.0%, 0.697, 0.625; Asn, His, Cit, Pro, Ile, Phe, 0.751, 0.692, 0.7%, 0.698, 0.641; Asn, His, Met, Lys, Ile, Leu, 0.751, 0.688, 3.7%, 0.665, 0.633; Asn, His, Pro, Tyr, Lys, Ile, 0.751, 0.715, 4.8%, 0.707, 0.696; Asn, His, Thr, Met, Lys, Ile, 0.751, 0.688, 3.3%, 0.666, 0.625; Asn, His, Tyr, Lys, Ile, Leu, 0.751, 0.710, 5.5%, 0.699, 0.682; Asn, His, Tyr, Orn, Ile, Leu, 0.751, 0.725, 4.8%, 0.725, 0.694; Asn, His, Val, Ile, Phe, Trp, 0.751, 0.692, 0.4%, 0.694, 0.623; Asn, Thr, Arg, Tyr, Leu, Phe, 0.751, 0.733, 2.2%, 0.730, 0.651; Asn, Thr, Cit, Lys, Ile, Phe, 0.751, 0.680, 1.8%, 0.660, 0.663; Asn, Thr, Val, Lys, Ile, Leu, 0.751, 0.675, 1.3%, 0.649, 0.651; Cit, Tyr, Val, Lys, Ile, Trp, 0.751, 0.715, 5.1%, 0.699, 0.718; Gln, Ala, Cit, Val, Ile, Leu, 0.751, 0.693, 0.7%, 0.704, 0.682; Gln, Ala, Pro, Tyr, Leu, Phe, 0.751, 0.722, 2.0%, 0.723, 0.686; Gln, Ala, Tyr, Orn, Leu, Trp, 0.751, 0.721, 4.8%, 0.713, 0.708; Gln, Arg, Pro, Lys, Ile, Phe, 0.751, 0.676, 1.3%, 0.667, 0.671; Gln, Cit, Lys, Ile, Leu, Trp, 0.751, 0.689, 0.4%, 0.675, 0.710; Gln, Cit, Lys, Ile, Phe, Trp, 0.751, 0.679, 0.6%, 0.665, 0.669; Gln, Cit, Orn, Ile, Leu, Phe, 0.751, 0.682, 0.9%, 0.680, 0.627; Gln, Cit, Pro, Tyr, Orn, Ile, 0.751, 0.707, 3.5%, 0.724, 0.740; Gln, His, Ala, Arg, Orn, Ile, 0.751, 0.693, 0.9%, 0.719, 0.714; Gln, His, Ala, Lys, Ile, Trp, 0.751, 0.701, 1.8%, 0.694, 0.710; Gln, His, Ala, Met, Ile, Leu, 0.751, 0.705, 0.9%, 0.721, 0.710; Gln, His, Ala, Pro, Tyr, Leu, 0.751, 0.726, 2.4%, 0.730, 0.750; Gln, His, Ala, Tyr, Lys, Ile, 0.751, 0.722, 3.3%, 0.729, 0.775; Gln, His, A

rg, Ile, Leu, Trp, 0.751, 0.708, 1.1%, 0.725, 0.700; Gln, His, Arg, Met, Ile, Leu, 0.751, 0.710, 0.4%, 0.731, 0.704; Gln, His, Arg, Pro, Tyr, Lys, 0.751, 0.727, 1.8%, 0.740, 0.785; Gln, His, Cit, Pro, Lys, Ile, 0.751, 0.696, 2.0%, 0.698, 0.726; Gln, His, Pro, Lys, Ile, Phe, 0.751, 0.693, 0.7%, 0.689, 0.653; Gln, His, Pro, Met, Orn, Ile, 0.751, 0.694, 1.3%, 0.713, 0.698; Gln, His, Thr, Ala, Val, Ile, 0.751, 0.705, 1.1%, 0.727, 0.736; Gln, His, Thr, Arg, Pro, Ile, 0.751, 0.706, 0.7%, 0.733, 0.736; Gln, His, Thr, Arg, Val, Ile, 0.751, 0.707, 0.7%, 0.733, 0.730; Gln, His, Thr, Met, Ile, Trp, 0.751, 0.707, 0.7%, 0.726, 0.720; Gln, His, Tyr, Val, Phe, Trp, 0.751, 0.739, 3.3%, 0.738, 0.704; Gln, His, Val, Ile, Leu, Trp, 0.751, 0.709, 1.5%, 0.720, 0.702; Gln, Orn, Lys, Ile, Phe, Trp, 0.751, 0.677, 0.6%, 0.654, 0.665; Gln, Pro, Tyr, Met, Ile, Leu, 0.751, 0.730, 4.4%, 0.731, 0.706; Gln, Pro, Tyr, Val, Lys, Trp, 0.751, 0.728, 6.6%, 0.704, 0.730; Gln, Thr, Ala, Arg, Lys, Ile, 0.751, 0.685, 0.9%, 0.687, 0.724; Gln, Thr, Arg, Tyr, Ile, Phe, 0.751, 0.726, 4.2%, 0.740, 0.708; Gln, Thr, Val, Lys, Ile, Trp, 0.751, 0.679, 1.1%, 0.657, 0.716; Gln, Val, Lys, Ile, Leu, Trp, 0.751, 0.679, 0.7%, 0.660, 0.700; Gly, Arg, Tyr, Val, Met, Lys, 0.751, 0.723, 4.4%, 0.700, 0.692; Gly, Cit, Pro, Tyr, Lys, Ile, 0.751, 0.701, 5.0%, 0.695, 0.736; Gly, Cit, Tyr, Lys, Ile, Phe, 0.751, 0.705, 5.0%, 0.695, 0.706; Gly, Gln, Cit, Lys, Ile, Leu, 0.751, 0.679, 0.6%, 0.662, 0.708; Gly, Gln, Cit, Orn, Ile, Trp, 0.751, 0.680, 2.0%, 0.678, 0.671; Gly, Gln, Cit, Tyr, Lys, Ile, 0.751, 0.710, 3.5%, 0.706, 0.753; Gly, Gln, Cit, Tyr, Orn, Leu, 0.751, 0.702, 2.4%, 0.696, 0.714; Gly, Gln, His, Ala, Pro, Ile, 0.751, 0.702, 1.1%, 0.718, 0.716; Gly, Gln, His, Ala, Val, Ile, 0.751, 0.701, 0.9%, 0.718, 0.724; Gly, Gln, His, Arg, Orn, Ile, 0.751, 0.694, 0.7%, 0.716, 0.700; Gly, Gln, His, Arg, Val, Ile, 0.751, 0.704, 0.9%, 0.725, 0.712; Gly, Gln, His, Cit, Lys, Ile, 0.751, 0.692, 1.1%, 0.690, 0.718; Gly, Gln, Met, Orn, Lys, Ile, 0.751, 0.677, 0.7%, 0.650, 0.694; Gly, Gln, Pro, Tyr, Met, Ile, 0.751, 0.724, 5.7%, 0.722, 0.720; Gly, Gln, Thr, Arg, Tyr, Ile, 0.751, 0.726, 6.2%, 0.732, 0.736; Gly, Gln, Thr, Met, Lys, Ile, 0.751, 0.674, 0.7%, 0.646, 0.692; Gly, Gln, Val, Lys, Ile, Trp, 0.751, 0.672, 0.9%, 0.647, 0.696; Gly, His, Cit, Tyr, Val, Ile, 0.751, 0.715, 3.7%, 0.712, 0.744; Gly, Thr, Tyr, Lys, Ile, Phe, 0.751, 0.711, 5.5%, 0.693, 0.680; Gly, Tyr, Ile, Leu, Phe, Trp, 0.751, 0.710, 4.2%, 0.691, 0.633; Gly, Tyr, Val, Met, Ile, Phe, 0.751, 0.722, 6.1%, 0.703, 0.665; His, Thr, Ala, Tyr, Met, Ile, 0.751, 0.725, 5.5%, 0.730, 0.712; His, Thr, Arg, Tyr, Lys, Ile, 0.751, 0.717, 8.3%, 0.717, 0.744; His, Thr, Arg, Tyr, Met, Ile, 0.751, 0.730, 5.1%, 0.738, 0.714; His, Thr, Pro, Tyr, Met, Ile, 0.751, 0.726, 5.0%, 0.728, 0.698; Ser, Arg, Lys, Ile, Leu, Phe, 0.751, 0.659, 0.7%, 0.639, 0.657; Ser, Arg, Val, Lys, Ile, Phe, 0.751, 0.655, 1.3%, 0.636, 0.653; Ser, Asn, Arg, Pro, Tyr, Lys, 0.751, 0.708, 7.4%, 0.693, 0.734; Ser, Asn, Arg, Tyr, Leu, Phe, 0.751, 0.729, 1.5%, 0.725, 0.639; Ser, Asn, Cit, Tyr, Ile, Phe, 0.751, 0.721, 4.6%, 0.728, 0.688; Ser, Asn, Gln, Ala, Lys, Ile, 0.751, 0.661, 3.3%, 0.638, 0.682; Ser, Asn, Gln, Tyr, Ile, Trp, 0.751, 0.713, 4.6%, 0.715, 0.732; Ser, Asn, Gly, His, Tyr, Ile, 0.751, 0.715, 4.8%, 0.715, 0.692; Ser, Asn, Pro, Tyr, Leu, Phe, 0.751, 0.723, 2.4%, 0.714, 0.641; Ser, Asn, Tyr, Leu, Phe, Trp, 0.751, 0.725, 2.6%, 0.711, 0.637; Ser, Gln, Met, Lys, Ile, Phe, 0.751, 0.660, 1.5%, 0.636, 0.671; Ser, Gln, Met, Lys, Ile, Trp, 0.751, 0.662, 1.5%, 0.632, 0.692; Ser, Gln, Thr, Tyr, Ile, Trp, 0.751, 0.712, 8.1%, 0.713, 0.757; Ser, Gln, Thr, Tyr, Lys, Leu, 0.751, 0.715, 3.9%, 0.706, 0.728; Ser, Gln, Tyr, Val, Leu, Trp, 0.751, 0.722, 4.8%, 0.707, 0.712; Ser, Gly, Cit, Tyr, Ile, Phe, 0.751, 0.715, 4.4%, 0.713, 0.700; Ser, Gly, Gln, Cit, Tyr, Leu, 0.751, 0.726, 2.4%, 0.716, 0.696; Ser, Gly, Gln, Tyr, Val, Phe, 0.751, 0.737, 5.9%, 0.719, 0.673; Ser, Gly, His, Tyr, Met, Ile, 0.751, 0.724, 4.4%, 0.718, 0.694; Ser, His, Arg, Tyr, Met, Ile, 0.751, 0.720, 5.5%, 0.727, 0.720; Ser, His, Tyr, Ile, Leu, Phe, 0.751, 0.717, 2.8%, 0.708, 0.661; Ser, His, Tyr, Met, Orn, Ile, 0.751, 0.723, 5.5%, 0.723, 0.716; Thr, Arg, Lys, Ile, Phe, Trp, 0.751, 0.671, 0.7%, 0.657, 0.667; Thr, Arg, Tyr, Val, Lys, Ile, 0.751, 0.716, 7.4%, 0.714, 0.740; Thr, Cit, Arg, Tyr, Ile, Phe, 0.751, 0.725, 4.4%, 0.735, 0.698; Thr, Tyr, Ile, Leu, Phe, Trp, 0.751, 0.725, 4.4%, 0.717, 0.663; Thr, Tyr, Met, Lys, Leu, Phe, 0.751, 0.723, 3.1%, 0.705, 0.653; Tyr, Lys, Ile, Leu, Phe, Trp, 0.751, 0.711, 4.2%, 0.691, 0.649; Ala, Arg, Tyr, Lys, Leu, Trp, 0.750, 0.709, 2.8%, 0.694, 0.694; Arg, Pro, Orn, Lys, Ile, Phe, 0.750, 0.661, 1.1%, 0.648, 0.639; Arg, Tyr, Orn, Lys, Leu, Phe, 0.750, 0.707, 1.7%, 0.700, 0.669; Asn, Ala, Cit, Lys, Ile, Trp, 0.750, 0.676, 2.0%, 0.666, 0.694; Asn, Ala, Cit, Met, Lys, Ile, 0.750, 0.676, 2.0%, 0.667, 0.692; Asn, Ala, Tyr, Lys, Leu, Trp, 0.750, 0.714, 3.5%, 0.691, 0.665; Asn, Arg, Pro, Lys, Ile, Leu, 0.750, 0.673, 2.8%, 0.662, 0.661; Asn, Cit, Orn, Lys, Ile, Trp, 0.750, 0.670, 2.0%, 0.657, 0.661; Asn, Gln, Val, Lys, Ile, Trp, 0.750, 0.673, 1.8%, 0.653, 0.688; Asn, Gly, Ala, Arg, Tyr, Ile, 0.750, 0.723, 5.9%, 0.718, 0.682; Asn, Gly, Tyr, Val, Leu, Phe, 0.750, 0.716, 2.4%, 0.696, 0.623; Asn, Thr, Arg, Pro, Lys, Ile, 0.750, 0.671, 2.9%, 0.659, 0.667; Asn, Thr, Cit, Tyr, Met, Ile, 0.750, 0.733, 5.1%, 0.738, 0.706; Asn, Thr, Val, Met, Lys, Ile, 0.750, 0.678, 2.6%, 0.651, 0.659; Gln, Arg, Pro, Tyr, Ile, Phe, 0.750, 0.725, 3.9%, 0.740, 0.706; Gln, Cit, Tyr, Met, Orn, Leu, 0.750, 0.712, 2.2%, 0.713, 0.708; Gln, His, Cit, Arg, Lys, Ile, 0.750, 0.697, 0.7%, 0.705, 0.716; Gln, His, Met, Orn, Ile, Trp, 0.750, 0.699, 1.8%, 0.718, 0.698; Gln, His, Pro, Val, Ile, Trp, 0.750, 0.707, 1.5%, 0.723, 0.710; Gln, His, Val, Lys, Ile, Trp, 0.750, 0.697, 1.3%, 0.692, 0.706; Gln, Pro, Tyr, Val, Ile, Trp, 0.750, 0.738, 8.5%, 0.726, 0.732; Gln, Thr, Ala, Tyr, Leu, Phe, 0.750, 0.724, 1.7%, 0.731, 0.680; Gln, Thr, Cit, Ile, Leu, Phe, 0.750, 0.687, 0.2%, 0.691, 0.671; Gln, Thr, Tyr, Val, Lys, Leu, 0.750, 0.719, 4.0%, 0.707, 0.730; Gln, Tyr, Val, Orn, Ile, Leu, 0.750, 0.722, 3.9%, 0.728, 0.742; Gly, Cit, Tyr, Val, Met, Ile, 0.750, 0.722, 6.6%, 0.710, 0.696; Gly, Gln, Ala, Tyr, Orn, Ile, 0.750, 0.729, 5.9%, 0.728, 0.738; Gly, Gln, His, Arg, Pro, Ile, 0.750, 0.702, 0.9%, 0.725, 0.712; Gly, Gln, Thr, Lys, Ile, Phe, 0.750, 0.671, 0.7%, 0.642, 0.657; Gly, Thr, Tyr, Lys, Leu, Phe, 0.750, 0.714, 3.1%, 0.697, 0.627; Gly, Tyr, Lys, Ile, Leu, Phe, 0.750, 0.706, 4.0%, 0.684, 0.641; His, Arg, Orn, Ile, Leu, Phe, 0.750, 0.675, 0.0%, 0.672, 0.613; Ser, Arg, Orn, Lys, Ile, Phe, 0.750, 0.655, 1.3%, 0.639, 0.659; Ser, Asn, Gln, Tyr, Orn, Ile, 0.750, 0.720, 5.0%, 0.726, 0.744; Ser, Asn, Lys, Ile, Leu, Phe, 0.750, 0.662, 1.8%, 0.630, 0.631; Ser, Cit, Tyr, Val, Orn, Ile, 0.750, 0.709, 5.5%, 0.713, 0.730; Ser, Gln, Ala, Tyr, Leu, Trp, 0.750, 0.717, 3.9%, 0.705, 0.712; Ser, Gln, Cit, Tyr, Orn, Ile, 0.750, 0.701, 3.7%, 0.718, 0.753; Ser, Gln, Cit, Tyr, Val, Ile, 0.750, 0.717, 3.9%, 0.729, 0.757; Ser, Gln, His, Arg, Ile, Leu, 0.750, 0.691, 0.6%, 0.708, 0.740; Ser, Gln, His, Pro, Tyr, Leu, 0.750, 0.725, 2.8%, 0.731, 0.748; Ser, Gln, His, Tyr, Val, Leu, 0.750, 0.729, 2.2%, 0.730, 0.736; Ser, Gln, His, Val, Lys, Ile, 0.750, 0.678, 1.7%, 0.674, 0.738; Ser, Gln, Tyr, Met, Leu, Trp, 0.750, 0.727, 4.2%, 0.715, 0.704; Ser, Gly, Cit, Tyr, Met, Ile, 0.750, 0.717, 7.4%, 0.707, 0.702; Ser, Gly, Gln, His, Cit, Ile, 0.750, 0.691, 0.7%, 0.703, 0.716; Ser, Gly, His, Arg, Tyr, Ile, 0.750, 0.716, 3.1%, 0.722, 0.724; Ser, His, Pro, Tyr, Met, Ile, 0.750, 0.722, 5.5%, 0.724, 0.714; Thr, Ala, Tyr, Lys, Ile, Phe, 0.750, 0.712, 5.5%, 0.703, 0.690; Tyr, Met, Ile, Leu, Phe, Trp, 0.750, 0.722, 4.8%, 0.710, 0.657; Ala, Arg, Orn, Lys, Ile, Phe, 0.750, 0.662, 0.7%, 0.658, 0.673; Ala, Cit, Arg, Lys, Ile, Phe, 0.750, 0.669, 0.7%, 0.663, 0.673; Ala, Tyr, Lys, Ile, Leu, Phe, 0.750, 0.707, 4.4%, 0.695, 0.669; Arg, Pro, Tyr, Lys, Leu, Phe, 0.750, 0.707, 1.3%, 0.698, 0.657; Asn, Arg, Tyr, Val, Orn, Lys, 0.750, 0.713, 3.5%, 0.703, 0.708; Asn, Cit, Pro, Tyr, Met, Ile, 0.750, 0.732, 5.1%, 0.736, 0.704; Asn, Gln, Ala, Cit, Ile, Leu, 0.750, 0.693, 0.6%, 0.705, 0.679; Asn, Gln, Cit, Arg, Tyr, Ile, 0.750, 0.728, 3.5%, 0.744, 0.742; Asn, Gln, Cit, Pro, Tyr, Ile, 0.750, 0.729, 3.5%, 0.745, 0.744; Asn, Gln, Thr, Arg, Leu, Phe, 0.750, 0.680, 0.0%, 0.675, 0.611; Asn, Gly, Gln, Cit, Pro, Ile, 0.750, 0.689, 0.7%, 0.692, 0.669; Asn, Gly, Gln, His, Orn, Leu, 0.750, 0.687, 0.9%, 0.682, 0.621; Asn, Gly, Gln, Tyr, Val, Trp, 0.750, 0.731, 8.5%, 0.708, 0.690; Asn, Gly, His, Cit, Tyr, Leu, 0.750, 0.717, 2.6%, 0.705, 0.657; Asn, Gly, Lys, Ile, Leu, Phe, 0.750, 0.677, 1.3%, 0.646, 0.619; Asn, Gly, Thr, Met, Lys, Ile, 0.750, 0.674, 2.6%, 0.648, 0.659; Asn, Gly, Thr, Tyr, Met, Leu, 0.750, 0.722, 6.2%, 0.703, 0.633; Asn, Gly, Thr, Val, Lys, Ile, 0.750, 0.674, 2.4%, 0.645, 0.651; Asn, His, Ala, Arg, Ile, Phe, 0.750, 0.688, 0.2%, 0.702, 0.649; Asn, His, Arg, Tyr, Leu, Phe, 0.750, 0.730, 1.5%, 0.730, 0.659; Asn, His, Arg, Tyr, Orn, Leu, 0.750, 0.716, 3.1%, 0.718, 0.671; Asn, His, Met, Ile, Phe, Trp, 0.750, 0.693, 0.4%, 0.697, 0.623; Asn, His, Pro, Tyr, Ile, Leu, 0.750, 0.723, 3.9%, 0.723, 0.698; Asn, His, Pro, Tyr, Orn, Ile, 0.750, 0.729, 3.7%, 0.735, 0.714; Asn, His, Tyr, Met, Lys, Leu, 0.750, 0.725, 4.2%, 0.708, 0.665; Asn, His, Tyr, Val, Lys, Ile, 0.750, 0.710, 6.2%, 0.700, 0.690; Asn, His, Tyr, Val, Orn, Ile, 0.750, 0.729, 5.0%, 0.730, 0.702; Asn, His, Val, Met, Lys, Ile, 0.750, 0.682, 4.0%, 0.660, 0.631; Asn, Thr, Lys, Ile, Leu, Trp, 0.750, 0.677, 1.5%, 0.653, 0.659; Gln, Ala, Cit, Val, Lys, Ile, 0.750, 0.679, 1.3%, 0.676, 0.734; Gln, Ala, Tyr, Orn, Leu, Phe, 0.750, 0.717, 2.4%, 0.720, 0.686; Gln, Ala, Tyr, Val, Ile, Trp, 0.750, 0.735, 7.5%, 0.726, 0.732; Gln, Arg, Tyr, Met, Orn, Leu, 0.750, 0.718, 3.5%, 0.720, 0.696; Gln, Cit, Tyr, Met, Leu, Trp, 0.750, 0.731, 3.3%, 0.724, 0.720; Gln, Cit, Tyr, Orn, Lys, Ile, 0.750, 0.704, 3.7%, 0.709, 0.777; Gln, His, Ala, Cit, Lys, Ile, 0.750, 0.697, 1.3%, 0.701, 0.736; Gln, His, Ala, Lys, Ile, Phe, 0.750, 0.689, 0.6%, 0.686, 0.671; Gln, His, Ala, Tyr, Val, Leu, 0.750, 0.724, 2.2%, 0.728, 0.751; Gln, His, Ar

g, Val, Met, Ile, 0.750, 0.710, 0.2%, 0.732, 0.708; Gln, His, Pro, Tyr, Val, Trp, 0.750, 0.737, 4.2%, 0.728, 0.736; Gln, His, Thr, Arg, Ile, Leu, 0.750, 0.707, 0.7%, 0.730, 0.730; Gln, Met, Lys, Ile, Leu, Trp, 0.750, 0.686, 0.7%, 0.657, 0.694; Gln, Met, Lys, Ile, Phe, Trp, 0.750, 0.678, 1.1%, 0.653, 0.665; Gln, Pro, Tyr, Met, Ile, Trp, 0.750, 0.736, 7.7%, 0.739, 0.744; Gln, Thr, Arg, Lys, Ile, Leu, 0.750, 0.684, 1.1%, 0.683, 0.720; Gln, Thr, Tyr, Met, Ile, Leu, 0.750, 0.730, 3.7%, 0.732, 0.712; Gln, Thr, Tyr, Orn, Leu, Trp, 0.750, 0.721, 7.7%, 0.711, 0.698; Gln, Thr, Val, Lys, Leu, Phe, 0.750, 0.678, 0.0%, 0.648, 0.625; Gln, Tyr, Orn, Lys, Leu, Trp, 0.750, 0.719, 4.2%, 0.700, 0.720; Gly, Ala, Cit, Tyr, Ile, Phe, 0.750, 0.710, 4.6%, 0.710, 0.704; Gly, Gln, Ala, Tyr, Orn, Leu, 0.750, 0.717, 2.8%, 0.708, 0.708; Gly, Gln, Cit, Pro, Tyr, Leu, 0.750, 0.717, 2.9%, 0.712, 0.714; Gly, Gln, His, Arg, Ile, Trp, 0.750, 0.702, 1.1%, 0.716, 0.692; Gly, Gln, His, Arg, Met, Ile, 0.750, 0.704, 0.9%, 0.722, 0.710; Gly, Gln, His, Met, Lys, Ile, 0.750, 0.689, 0.9%, 0.678, 0.696; Gly, Gln, Met, Lys, Ile, Trp, 0.750, 0.676, 0.7%, 0.645, 0.690; Gly, Gln, Pro, Tyr, Val, Ile, 0.750, 0.724, 5.9%, 0.720, 0.726; Gly, Gln, Thr, Orn, Lys, Ile, 0.750, 0.678, 0.7%, 0.650, 0.696; Gly, Gln, Tyr, Val, Met, Phe, 0.750, 0.726, 6.8%, 0.706, 0.673; Gly, Thr, Cit, Tyr, Met, Ile, 0.750, 0.718, 8.6%, 0.709, 0.704; His, Arg, Lys, Ile, Leu, Phe, 0.750, 0.679, 0.6%, 0.664, 0.661; His, Arg, Met, Lys, Ile, Leu, 0.750, 0.683, 1.1%, 0.671, 0.679; His, Cit, Pro, Tyr, Lys, Ile, 0.750, 0.708, 3.9%, 0.709, 0.757; Ser, Arg, Met, Lys, Ile, Trp, 0.750, 0.656, 2.8%, 0.635, 0.682; Ser, Arg, Tyr, Ile, Leu, Trp, 0.750, 0.707, 5.5%, 0.696, 0.700; Ser, Asn, Arg, Val, Lys, Ile, 0.750, 0.648, 2.9%, 0.637, 0.667; Ser, Asn, Gln, Met, Lys, Leu, 0.750, 0.675, 0.2%, 0.645, 0.639; Ser, Asn, Gln, Pro, Tyr, Ile, 0.750, 0.714, 4.6%, 0.722, 0.736; Ser, Asn, His, Lys, Ile, Trp, 0.750, 0.670, 3.5%, 0.652, 0.669; Ser, Asn, Thr, Tyr, Ile, Leu, 0.750, 0.715, 5.9%, 0.708, 0.684; Ser, Gln, Arg, Tyr, Ile, Leu, 0.750, 0.716, 3.1%, 0.725, 0.744; Ser, Gln, Arg, Tyr, Leu, Phe, 0.750, 0.732, 1.7%, 0.736, 0.692; Ser, Gln, His, Cit, Lys, Ile, 0.750, 0.684, 0.7%, 0.681, 0.730; Ser, Gln, His, Thr, Ile, Phe, 0.750, 0.689, 0.4%, 0.704, 0.682; Ser, Gln, Thr, Lys, Leu, Phe, 0.750, 0.673, 0.2%, 0.642, 0.617; Ser, Gln, Tyr, Val, Lys, Trp, 0.750, 0.729, 6.4%, 0.707, 0.730; Ser, His, Tyr, Met, Ile, Leu, 0.750, 0.724, 5.1%, 0.720, 0.700; Ser, Thr, Arg, Lys, Ile, Trp, 0.750, 0.653, 2.8%, 0.630, 0.688; Ser, Thr, Cit, Tyr, Ile, Phe, 0.750, 0.715, 4.6%, 0.724, 0.698; Ser, Tyr, Met, Ile, Leu, Phe, 0.750, 0.720, 4.4%, 0.709, 0.659; Thr, Arg, Tyr, Lys, Leu, Phe, 0.750, 0.724, 2.4%, 0.720, 0.665; Thr, Arg, Val, Lys, Ile, Phe, 0.750, 0.673, 0.7%, 0.661, 0.671; Thr, Tyr, Lys, Leu, Phe, Trp, 0.750, 0.723, 3.3%, 0.705, 0.655 [10. Six-variable formula including amino acids]
Gln, His, Tyr, Ile, Phe, Trp, 0.785, 0.746, 4.2%, 0.767, 0.746; Asn, Gly, Gln, Tyr, Leu, Phe, 0.780, 0.733, 2.9%, 0.722, 0.657; Arg, Tyr, Ile, Phe, 0.780, 0.738, 2.0%, 0.765, 0.751; Asn, Gln, His, Cit, Orn, Ile, 0.780, 0.699, 1.8%, 0.719, 0.708; Gln, His, Tyr, Met, Ile, Phe, 0.780, 0.741, 2.0%, 0.762, 0.736; Asn, Arg, Tyr, Lys, Ile, Phe, 0.779, 0.724, 4.0%, 0.720, 0.708; Arg, Tyr, Met, Lys, Ile, Phe, Asn, Arg, Tyr, Met, Lys, Ile, 0.778, 0.727, 5.9%, 0.726, 0.724; Asn, Gly, Arg, Tyr, Lys, Ile, 0.778, 0.715, 4.6%, 0.704, 0.704; Gln, His, Tyr, Ile, Leu, Phe, 0.778, 0.738, 2.2%, 0.754, 0.726; Gln, His, Tyr, Orn, Ile, Phe, 0.778, 0.733, 2.2%, 0.755 , 0.732; His, Arg, Tyr, Lys, Ile, Phe, 0.778, 0.721, 2.9%, 0.725, 0.722; Arg, Tyr, Lys, Ile, Phe, Trp, 0.777, 0.723, 4.0%, 0.717, 0.712; , Gln, His, Tyr, Ile, Trp, 0.777, 0.744, 5.5%, 0.763, 0.765; Gly, Arg, Tyr, Lys, Ile, Phe, 0.777, 0.719, 2.2%, 0.714, 0.706; Arg, Tyr, Lys , Ile, Leu, Phe, 0.777, 0.7 23, 3.1%, 0.721, 0.706; Asn, Gln, His, Tyr, Ile, Phe, 0.777, 0.737, 1.8%, 0.760, 0.726; Gln, His, Ala, Tyr, Ile, Phe, 0.777, 0.736, 2.2% , 0.757, 0.740; Gln, His, Tyr, Val, Ile, Phe, 0.777, 0.736, 2.2%, 0.755, 0.732; Gln, Tyr, Lys, Ile, Leu, Phe, 0.777, 0.730, 4.4%, 0.728, 0.722 Ser, Gln, His, Tyr, Ile, Phe, 0.777, 0.733, 2.4%, 0.755, 0.742; Arg, Tyr, Orn, Lys, Ile, Phe, 0.776, 0.721, 2.9%, 0.723, 0.726; Gly, Gln , His, Tyr, Ile, Phe, 0.776, 0.733, 2.8%, 0.750, 0.736; Gly, Gln, His, Tyr, Met, Ile, 0.776, 0.739, 5.5%, 0.753, 0.744; , Ile, Trp, 0.776, 0.728, 4.4%, 0.741, 0.755; Asn, Gly, Gln, His, Tyr, Ile, 0.775, 0.732, 3.3%, 0.750, 0.748; Gln, Tyr, Ile, Leu, Phe, Trp , 0.775, 0.737, 4.4%, 0.739, 0.704; Gly, Gln, His, Tyr, Ile, Trp, 0.775, 0.736, 6.2%, 0.744, 0.750; Gly, Gln, Tyr, Ile, Leu, Phe, 0.775, 0.727 Arg, Tyr, Val, Lys, Ile, Phe, 0.775, 0.722, 2.8%, 0.721, 0.718; Asn, Gln, His, Cit, Ile, Phe, 0.775, 0.711, 0.2%, 0.739, 0.679; Asn, Gln, His, L ys, Ile, Phe, 0.775, 0.702, 0.7%, 0.700, 0.641; Gln, His, Cit, Orn, Ile, Phe, 0.775, 0.695, 0.6%, 0.710, 0.684; Phe, 0.775, 0.735, 2.2%, 0.756, 0.734; Gln, His, Thr, Tyr, Ile, Phe, 0.775, 0.741, 2.8%, 0.761, 0.734; Gln, His, Tyr, Lys, Ile, Phe, 0.775, Ser, Arg, Tyr, Lys, Ile, Phe, 0.775, 0.717, 2.6%, 0.719, 0.722; Ser, Asn, Gln, His, Tyr, Ile, 0.775, 0.734, 3.5% , 0.754, 0.763; Arg, Tyr, Met, Lys, Ile, Trp, 0.774, 0.725, 5.7%, 0.720, 0.736; Asn, Gln, His, Tyr, Met, Ile, 0.774, 0.743, 3.1%, 0.765, 0.751 Gln, His, Tyr, Leu, Phe, Trp, 0.774, 0.743, 2.0%, 0.745, 0.704; Asn, Arg, Tyr, Lys, Ile, Trp, 0.773, 0.718, 6.6%, 0.713, 0.726; Asn, Cit , Arg, Tyr, Lys, Ile, 0.773, 0.721, 5.1%, 0.721, 0.748; Gln, His, Cit, Tyr, Ile, Phe, 0.773, 0.736, 2.0%, 0.760, 0.750; Asn, Gln, Arg, Tyr, Lys, Ile, 0.773, 0.730, 5.7%, 0.731, 0.759; Asn, Gln, Tyr, Ile, Leu, Phe , 0.773, 0.734, 3.1%, 0.736, 0.686; Asn, His, Arg, Tyr, Lys, Ile, 0.773, 0.721, 4.8%, 0.728, 0.746; Gly, Arg, Tyr, Met, Lys, Ile, 0.773, 0.720, 4.2%, 0.708, 0.716; His, Arg, Tyr, Orn, Ile, 0.772, 0.729, 2.2%, 0.760, 0.791; Gln, Pro, Tyr, Lys, Ile, Phe, 0.772, 0.725, 5.5%, 0.720, 0.726; Gln, Tyr, Met, Lys, Ile, Phe, 0.772, 0.727, 6.1%, 0.723, 0.722; His, Tyr, Met, Lys, Ile, Phe, 0.772, 0.726, 3.7%, 0.715, 0.688; Asn, Gln, His, Tyr, Orn, Ile, 0.771, 0.734, 3.9%, 0.756, 0.753; Asn, Gln, His, Val, Ile, Phe, 0.771, 0.708, 0.0%, 0.743, 0.677; Gly, Gln, Arg, Tyr, Lys, Ile, 0.771, Gly, Gln, Tyr, Leu, Phe, Trp, 0.771, 0.730, 2.9%, 0.719, 0.675; Ser, Gln, Tyr, Lys, Ile, Phe, 0.771, 0.719, 5.5% , 0.713, 0.736; Thr, Arg, Tyr, Lys, Ile, Phe, 0.771, 0.722, 4.6%, 0.725, 0.710; Asn, Gln, His, Ala, Cit, Ile, 0.771, 0.715, 0.7%, 0.743, 0.720 Asn, Gln, His, Cit, Arg, Ile, 0.771, 0.717, 0.9%, 0.743, 0.726; Asn, Gln, His, Thr, Tyr, Ile, 0.771, 0.741, 4.0%, 0.762, 0.755; Asn, Gln , Tyr, Lys, Ile, Phe, 0. 771, 0.726, 7.4%, 0.715, 0.700; Gln, Arg, Tyr, Ile, Leu, Phe, 0.771, 0.734, 2.8%, 0.744, 0.704; Gln, His, Cit, Tyr, Ile, Trp, 0.771, 0.744, 4.0%, 0.765, 0.787; Gln, His, Cit, Tyr, Orn, Ile, 0.771, 0.718, 2.4%, 0.748, 0.795; Gly, Gln, His, Tyr, Leu, Phe, 0.771, 0.726, 2.9%, 0.722 , 0.692; Ala, Arg, Tyr, Lys, Ile, Phe, 0.770, 0.716, 2.6%, 0.722, 0.730; Asn, Gln, His, Arg, Ile, Phe, 0.770, 0.709, 0.0%, 0.740, 0.675; , Gln, His, Cit, Pro, Ile, 0.770, 0.717, 1.1%, 0.744, 0.722; Asn, Gln, His, Pro, Tyr, Ile, 0.770, 0.738, 3.9%, 0.760, 0.759; , Tyr, Ile, Leu, 0.770, 0.735, 3.9%, 0.752, 0.755; Cit, Arg, Tyr, Lys, Ile, Phe, 0.770, 0.718, 2.8%, 0.720, 0.722; , Phe, 0.770, 0.729, 4.0%, 0.733, 0.736; Gln, Cit, Tyr, Ile, Leu, Phe, 0.770, 0.731, 2.4%, 0.746, 0.706; Gln, His, Ala, Tyr, Ile, Trp, 0.770 , 0.741, 5.1%, 0.755, 0.761; Gln, His, Cit, Arg, Ile, Phe, 0.770, 0.712, 0.2%, 0.733, 0.692; Gln, His, Cit, Pro, Orn, Ile, 0.770, 0.696, 1.5 %, 0.709, 0.714; Ser, Gln , Tyr, Met, Ile, Phe, 0.770, 0.721, 5.9%, 0.733, 0.716; Asn, Arg, Tyr, Orn, Lys, Ile, 0.770, 0.716, 5.3%, 0.714, 0.730; , Lys, Ile, 0.770, 0.715, 5.3%, 0.711, 0.724; Asn, Gln, Arg, Orn, Lys, Ile, 0.770, 0.677, 2.8%, 0.673, 0.694; Asn, Gln, His, Arg, Tyr, Ile , 0.770, 0.739, 3.3%, 0.763, 0.771; Asn, Gln, His, Cit, Ile, Trp, 0.770, 0.718, 1.1%, 0.741, 0.718; Asn, Gln, His, Met, Ile, Phe, 0.770, 0.712 , 0.2%, 0.743, 0.684; Gln, His, Arg, Tyr, Ile, Trp, 0.770, 0.743, 4.2%, 0.764, 0.765; Gln, His, Cit, Ile, Leu, Phe, 0.770, 0.712, 0.0%, Gln, His, Thr, Tyr, Orn, Ile, 0.770, 0.729, 3.9%, 0.752, 0.765; Gln, His, Tyr, Ile, Leu, Trp, 0.770, 0.738, 5.0%, 0.747, 0.742; Gln, His, Tyr, Met, Ile, Trp, 0.770, 0.746, 6.1%, 0.762, 0.755; Gln, His, Tyr, Orn, Ile, Trp, 0.770, 0.735, 5.3%, 0.750, 0.751; Gln, His, Tyr, Orn, Leu, Phe, 0.770, 0.725, 1.3%, 0.731, 0.696; Gln, Pro, Tyr, Ile, Leu, Phe, 0.770, 0.731, 3.3%, 0.736, 0.706; Gln, Tyr, Val, Lys, Ile, Phe, 0.770, 0.724, 5.5% , 0.719, 0.726; Gly, Gln, His, Cit, Ile, Phe, 0.770, 0.705, 0.2%, 0.723, 0.677; Gly, Gln, Tyr, Met, Ile, Phe, 0.770, 0.722, 5.3%, 0.725, 0.710 Ser, Gln, Tyr, Ile, Leu, Phe, 0.770, 0.725, 3.3%, 0.732, 0.708; Asn, Ala, Arg, Tyr, Lys, Ile, 0.769, 0.717, 5.3%, 0.714, 0.730; Asn, Arg , Tyr, Lys, Ile, Leu, 0.769, 0.717, 4.4%, 0.716, 0.728; Asn, Gln, His, Ala, Tyr, Ile, 0.769, 0.738, 3.9%, 0.759, 0.765; , Leu, Phe, 0.769, 0.710, 0.0%, 0.737, 0.671; Asn, Gln, His, Ile, Phe, Trp, 0.769, 0.710, 0.0%, 0.738, 0.673; , 0.769, 0.737, 3.9%, 0.759, 0.763; Gln, His, Ala, Arg, Tyr, Ile, 0.769, 0.735, 2.2%, 0.760, 0.787; Gln, His, Cit, Orn, Ile, Leu, 0.769, 0.697 , 0.9%, 0.717, 0.730; Gln, His, Cit, Val, Orn, Ile, 0.769, 0.696, 0.9%, 0.715, 0.728; Gln, Tyr, Lys, Leu, Phe, Trp, 0.769, 0.733, 2.6%, 0.722, 0.696; Gly, Gln, His, Tyr, Val, Trp, 0.769, 0.740, 5.1%, 0.728, 0.732; Gly, Gln, Tyr, Met, Leu, Phe, 0.769, 0.726, 2.6%, 0.715, 0.671; Asn, Arg, Pro, Tyr, Lys, Ile, 0.768, 0.715, 5.1%, 0.712, 0.722; Asn, Gln, His, Orn, Ile, Phe, 0.768, 0.692, 0.7%, 0.718, 0.659; Asn, Gly, Cit, Tyr, Ile, Leu, 0.768, 0.721, 4.6%, 0.717, 0.696; Asn, Gly, Gln, Cit, Tyr, Ile, 0.768, 0.728, 5.9%, 0.731, 0.720; Asn, Gly, Gln, Tyr, Lys, Leu, 0.768, 0.727, 4.0% , 0.707, 0.692; Asn, Thr, Arg, Tyr, Lys, Ile, 0.768, 0.721, 5.3%, 0.718, 0.730; Gln, His, Cit, Ile, Phe, Trp, 0.768, 0.712, 0.2%, 0.732, 0.682 Gln, His, Cit, Pro, Ile, Phe, 0.768, 0.710, 0.2%, 0.732, 0.680; Gln, Tyr, Orn, Ile, Leu, Phe, 0.768, 0.727, 3.3%, 0.733, 0.696; Gln, Tyr , Val, Ile, Phe, Trp, 0.768, 0.735, 7.5%, 0.737, 0.706; Ser, Gln, His, Tyr, Met, Ile, 0.768, 0.734, 5.3%, 0.750, 0.759; , Ile, Trp, 0.768, 0.717, 7.0%, 0.711, 0.722; Asn, Cit, Tyr, Met, Lys, Ile, 0.768, 0.720, 7.4%, 0.712, 0.724; Asn, Gln, Arg, Lys, Ile, Phe , 0.768, 0.682, 1.8%, 0.675, 0.679; Asn, Gln, His, Cit, Val, Ile, 0.768, 0.715, 0.9%, 0.743, 0.724; Asn, Gln, His, Val, Lys, Ile, 0.768, 0.694 , 3.3%, 0.696, 0.728; Asn, Gln, Tyr, Leu, Phe, Trp, 0.768, 0.738, 2.4%, 0.733, 0.671; Asn, Gly, Arg, Tyr, Lys, Leu, 0.768, 0.721, 2.8%, 0.704, 0.680; Asn, Gly, Gln, His, Tyr, Leu, 0.768, 0.730, 2.6%, 0.727, 0.706; Asn, His, Arg, Lys, Ile, Phe, 0.768, 0.688, 0.7%, 0.683, 0.665; Gln, His, Arg, Lys, Ile, Phe, 0.768, 0.701, 0.2%, 0.710, 0.710; Gln, His, Cit, Pro, Val, Ile, 0.768, 0.712, 1.1%, 0.739, 0.742; Gln, His, Cit, Val, Ile, Phe, Gly, Gln, His, Cit, Orn, Ile, 0.768, 0.693, 0.7%, 0.704, 0.724; Gly, Gln, Tyr, Met, Lys, Ile, 0.768, 0.719, 5.1%, 0.700, 0.722; Gly, Gln, Tyr, Val, Leu, Phe, 0.768, 0.724, 2.4%, 0.718, 0.690; His, Arg, Tyr, Met, Lys, Ile, 0.768, 0.727, 7.0%, 0.726 Ser, Gln, His, Cit, Orn, Ile, 0.768, 0.692, 0.9%, 0.706, 0.734; Ser, Gln, Tyr, Ile, Phe, Trp, 0.768, 0.720, 6.8%, 0.729, 0.724; Asn , Gln, His, Ala, Ile, Trp, 0.767, 0.710, 1.7%, 0.730, 0.696; Asn, Gln, His, Pro, Val, Ile, 0.767, 0.713, 1.7%, 0.741, 0.726; , Thr, Ile, Phe, 0.767, 0.7 07, 0.2%, 0.735, 0.682; Asn, Gln, Tyr, Lys, Leu, Phe, 0.767, 0.731, 2.2%, 0.719, 0.671; Asn, Gln, Tyr, Met, Leu, Phe, 0.767, 0.738, 2.2% , 0.737, 0.677; Asn, His, Tyr, Met, Lys, Ile, 0.767, 0.727, 6.8%, 0.718, 0.702; Gln, His, Ala, Tyr, Orn, Ile, 0.767, 0.727, 2.4%, 0.751, 0.773 Gln, His, Arg, Pro, Tyr, Ile, 0.767, 0.734, 2.4%, 0.759, 0.785; Gln, His, Cit, Arg, Orn, Ile, 0.767, 0.698, 0.9%, 0.715, 0.722; Gln, His , Cit, Met, Orn, Ile, 0.767, 0.697, 0.9%, 0.712, 0.722; Gln, His, Tyr, Met, Orn, Ile, 0.767, 0.735, 6.2%, 0.755, 0.751; Gln, Tyr, Met, Ile Gln, Tyr, Val, Ile, Leu, Phe, 0.767, 0.730, 2.9%, 0.740, 0.698; Gly, Gln, Pro, Tyr, Leu, Phe Ser, Asn, Gln, Tyr, Leu, Phe, 0.767, 0.737, 2.2%, 0.736, 0.675; Ser, Gln, Arg, Tyr, Lys, Ile, 0.767, 0.715 , 3.3%, 0.720, 0.783; Asn, Cit, Tyr, Ile, Leu, Phe, 0.766, 0.726, 2.0%, 0.724, 0.673; Asn, Gln, Cit, Tyr, Leu, Phe, 0.766, 0.737, 1.7%, 0.737, 0.675; Asn, Gln, His, P ro, Ile, Phe, 0.766, 0.708, 0.4%, 0.738, 0.669; Asn, Gly, Gln, His, Cit, Ile, 0.766, 0.709, 1.5%, 0.728, 0.700; A

sn, Gly, His, Tyr, Met, Ile, 0.766, 0.734, 5.0%, 0.738, 0.702; Gln, Arg, Tyr, Lys, Leu, Phe, 0.766, 0.732, 1.3%, 0.733, 0.708; Ala, Cit, Pro, Ile, 0.766, 0.712, 1.1%, 0.737, 0.736; Gln, His, Cit, Met, Ile, Phe, 0.766, 0.708, 0.2%, 0.731, 0.704; Gln, His, Thr, Arg, Tyr, Ile, 0.766, 0.738, 2.8%, 0.762, 0.787; Gln, His, Tyr, Val, Ile, Trp, 0.766, 0.739, 5.1%, 0.750, 0.755; Gln, Thr, Tyr, Lys, Ile, Phe, Gly, Gln, Ala, Tyr, Ile, Phe, 0.766, 0.723, 5.7%, 0.726, 0.706; Gly, Gln, Pro, Tyr, Ile, Phe, 0.766, 0.722, 4.8%, 0.726, 0.712; Gly, Gln, Thr, Tyr, Leu, Phe, 0.766, 0.726, 2.4%, 0.721, 0.673; Gly, Gln, Tyr, Lys, Ile, Phe, 0.766, 0.717, 5.0%, 0.701 Ser, Gln, Tyr, Orn, Ile, Phe, 0.766, 0.724, 4.8%, 0.735, 0.716; Arg , Pro, Tyr, Lys, Ile, Phe, 0.766, 0.713, 2.2%, 0.714, 0.714; Asn, Cit, Tyr, Lys, Ile, Leu, 0.766, 0.717, 4.0%, 0.713, 0.714; , Ala, Ile, Leu, 0.766, 0.71 1, 1.7%, 0.734, 0.710; Asn, Gln, His, Ala, Orn, Ile, 0.766, 0.699, 2.0%, 0.722, 0.700; Asn, Gln, His, Ala, Val, Ile, 0.766, 0.710, 1.7% , 0.737, 0.722; Asn, Gln, His, Arg, Lys, Ile, 0.766, 0.694, 2.0%, 0.702, 0.704; Asn, Gln, His, Thr, Ala, Ile, 0.766, 0.710, 1.7%, 0.733, 0.726 Asn, Gln, His, Val, Ile, Leu, 0.766, 0.713, 1.1%, 0.739, 0.722; Asn, Gln, Tyr, Orn, Leu, Phe, 0.766, 0.731, 2.4%, 0.728, 0.669; Asn, Gly , Arg, Orn, Lys, Ile, 0.766, 0.666, 2.9%, 0.656, 0.667; Cit, Arg, Tyr, Orn, Lys, Ile, 0.766, 0.704, 3.7%, 0.715, 0.750; , Leu, Phe, 0.766, 0.684, 1.1%, 0.682, 0.688; Gln, Arg, Orn, Lys, Ile, Trp, 0.766, 0.679, 1.1%, 0.675, 0.710; Gln, Arg, Tyr, Met, Lys, Ile , 0.766, 0.728, 3.7%, 0.733, 0.763; Gln, His, Arg, Orn, Ile, Phe, 0.766, 0.693, 0.4%, 0.718, 0.682; Gln, His, Cit, Arg, Pro, Ile, 0.766, 0.712 , 1.1%, 0.735, 0.736; Gln, His, Cit, Pro, Ile, Leu, 0.766, 0.712, 1.1%, 0.735, 0.734; Gln, His, Thr, Tyr, Ile, Trp, 0.766, 0.744, 5.9%, 0.758, 0.759; Gln, His, Tyr, Ly s, Leu, Phe, 0.766, 0.733, 1.5%, 0.730, 0.722; Gln, Pro, Tyr, Lys, Leu, Phe, 0.766, 0.726, 2.6%, 0.719, 0.690; Gly, Arg, Tyr, Val, Lys, Ile, 0.766, 0.711, 4.2%, 0.704, 0.728; Gly, Cit, Arg, Tyr, Lys, Ile, 0.766, 0.709, 2.6%, 0.706, 0.736; Gly, Gln, His, Arg, Tyr, Ile, 0.766, His, Arg, Tyr, Met, Ile, Phe, 0.766, 0.727, 2.6%, 0.735, 0.702; Ser, Gln, Pro, Tyr, Ile, Phe, 0.766, 0.720, 5.5% , 0.732, 0.718; Ser, Gln, Tyr, Met, Lys, Ile, 0.766, 0.715, 5.3%, 0.706, 0.744; Asn, Gln, Arg, Lys, Ile, Trp, 0.765, 0.682, 2.2%, 0.678, 0.706 Asn, Gln, Cit, Tyr, Lys, Ile, 0.765, 0.723, 5.3%, 0.726, 0.750; Asn, Gln, His, Ala, Pro, Ile, 0.765, 0.711, 1.7%, 0.734, 0.714; Asn, Gln , His, Cit, Ile, Leu, 0.765, 0.716, 0.7%, 0.743, 0.722; Asn, Gln, His, Tyr, Leu, Phe, 0.765, 0.740, 1.1%, 0.746, 0.688; Asn, Gln, Tyr, Ile , Leu, Trp, 0.765, 0.736, 6.6%, 0.735, 0.720; Asn, Gln, Tyr, Val, Leu, Phe, 0.765, 0.736, 1.8%, 0.737, 0.671; , 0.765, 0.675, 1.8%, 0.662, 0.655; Asn, Gly, Gln, Tyr, Ile, Leu, 0.765, 0.723, 5.0%, 0.717, 0.698; Asn, Gly, Gln, Tyr, Leu, Trp, 0.765, 0.731, 4.6%, 0.713, 0.686; His, Cit, Tyr, Met, Ile, 0.765, 0.735, 2.9%, 0.748, 0.728; Gln, Arg, Lys, Ile, Phe, Trp, 0.765, 0.682, 1.1%, 0.679, 0.690; Lys, Ile, Trp, 0.765, 0.690, 1.7%, 0.687, 0.726; Gln, His, Arg, Tyr, Val, Ile, 0.765, 0.735, 2.4%, 0.760, 0.785; Gln, His, Cit, Orn, Ile, Trp, 0.765, 0.696, 2.4%, 0.713, 0.690; Gln, His, Pro, Tyr, Leu, Phe, 0.765, 0.731, 2.2%, 0.735, 0.696; Gln, His, Thr, Cit, Orn, Ile, 0.765, 0.695, 1.1%, 0.710, 0.728; Gln, Pro, Tyr, Ile, Phe, Trp, 0.765, 0.734, 6.8%, 0.745, 0.718; Gln, Thr, Tyr, Ile, Leu, Phe, 0.765, 0.732, 2.9% Gln, Tyr, Orn, Leu, Phe, Trp, 0.765, 0.729, 3.3%, 0.726, 0.688; Gly, Gln, Tyr, Ile, Phe, Trp, 0.765, 0.722, 6.2%, 0.723, 0.710 Gly, Gln, Tyr, Orn, Leu, Phe, 0.765, 0.723, 2.6%, 0.715, 0.682; Gly, His, Arg, Tyr, Lys, Ile, 0.765, 0.710, 2.9%, 0.707, 0.734; His, Thr , Cit, Tyr, Ile, Phe, 0.7 Ser, Arg, Tyr, Lys, Ile, Trp, 0.765, 0.706, 5.3%, 0.691, 0.724; Ser, Asn, Gln, Tyr, Ile, Leu, 0.765, 0.721, 3.5%, 0.724, 0.716; Ser, Gln, His, Arg, Tyr, Ile, 0.765, 0.726, 2.4%, 0.751, 0.785; Ser, Gln, Thr, Tyr, Ile, Phe, 0.765, 0.721, 4.6%, 0.734 Ser, His, Arg, Tyr, Lys, Ile, 0.765, 0.708, 2.9%, 0.706, 0.751; Asn, Gln, His, Arg, Val, Ile, 0.764, 0.715, 1.1%, 0.743, 0.726; Asn , Gln, His, Cit, Met, Ile, 0.764, 0.716, 0.6%, 0.742, 0.720; Asn, Gln, His, Thr, Cit, Ile, 0.764, 0.712, 0.9%, 0.738, 0.726; , Val, Orn, Ile, 0.764, 0.697, 2.0%, 0.720, 0.704; Asn, Gly, Gln, Tyr, Lys, Ile, 0.764, 0.717, 6.2%, 0.698, 0.708; Asn, His, Cit, Tyr, Orn , Ile, 0.764, 0.714, 3.5%, 0.730, 0.728; Gln, Arg, Val, Lys, Ile, Phe, 0.764, 0.681, 1.1%, 0.681, 0.702; Gln, His, Ala, Cit, Tyr, Ile, 0.764 , 0.736, 2.6%, 0.762, 0.797; Gln, His, Arg, Ile, Phe, Trp, 0.764, 0.709, 0.0%, 0.733, 0.684; Gln, His, Arg, Pro, Ile, Phe, 0.764, 0.707, 0.2 %, 0.732, 0.673; Gln, His, Cit, Pro, Ile, Trp, 0.764, 0.715, 1.5%, 0.733, 0.724; Gln, His, Ile, Leu, Phe, Trp, 0.764, 0.709, 0.2%, 0.728, 0.686; Ile, Trp, 0.764, 0.741, 5.9%, 0.756, 0.767; Gln, His, Thr, Cit, Pro, Ile, 0.764, 0.712, 1.1%, 0.735, 0.744; Gln, His, Tyr, Met, Leu, Phe, Gln, Pro, Tyr, Leu, Phe, Trp, 0.764, 0.733, 4.0%, 0.728, 0.682; Gln, Thr, Arg, Lys, Ile, Trp, 0.764, 0.687, 1.5%, 0.683, 0.726; Gln, Tyr, Met, Orn, Leu, Phe, 0.764, 0.725, 2.4%, 0.728, 0.677; Gly, Gln, His, Cit, Tyr, Ile, 0.764, 0.731, 2.4%, 0.752 , 0.783; Gly, Gln, Tyr, Lys, Ile, Leu, 0.764, 0.717, 4.0%, 0.708, 0.726; , Arg, Tyr, Orn, Ile, Phe, 0.764, 0.718, 3.1%, 0.730, 0.694; Ser, Asn, Gln, His, Ile, Phe, 0.764, 0.690, 0.4%, 0.719, 0.680; Ser, Asn, Gln , His, Orn, Ile, 0.764, 0.690, 0.9%, 0.708, 0.708; Ser, Gly, Gln, Tyr, Ile, Phe, 0.764, 0.716, 5.5%, 0.721, 0.710; , Phe, 0.764, 0.727, 1.5%, Asn, Cit, Tyr, Orn, Lys, Ile, 0.764, 0.709, 5.7%, 0.707, 0.728; Asn, Gln, Ala, Arg, Lys, Ile, 0.764, 0.678, 2.8%, 0.677, 0.712; Asn, Gln, His, Cit, Tyr, Ile, 0.764, 0.737, 2.2%, 0.765, 0.779; Asn, Gln, His, Thr, Orn, Ile, 0.764, 0.699, 2.2%, 0.722, 0.698; His, Val, Met, Ile, 0.764, 0.712, 1.3%, 0.737, 0.722; Asn, Gln, Tyr, Orn, Ile, Phe, 0.764, 0.734, 5.7%, 0.746, 0.704; Asn, Gln, Val, Lys, Ile, Leu, 0.764, 0.678, 1.8%, 0.663, 0.686; Asn, Gly, Cit, Pro, Tyr, Ile, 0.764, 0.725, 7.4%, 0.726, 0.718; Gln, Arg, Orn, Lys, Ile, Phe, Gln, Cit, Tyr, Lys, Ile, Phe, 0.764, 0.723, 3.7%, 0.726, 0.730; Gln, His, Ala, Cit, Orn, Ile, 0.764, 0.693, 1.1%, 0.706, 0.726; Gln, His, Ala, Tyr, Met, Ile, 0.764, 0.741, 5.7%, 0.757, 0.748; Gln, His, Ala, Tyr, Val, Ile, 0.764, 0.732, 2.8%, 0.752 , 0.771; Gln, His, Arg, Val, Ile, Phe, 0.764, 0.708, 0.0%, 0.731, 0.682; Gln, His, Cit, Pro, Tyr, Ile, 0.764, 0.736, 2.8%, 0.760, 0.799; , His, Pro, Tyr, Met, Ile, 0.764, 0.743, 5.5%, 0.758, 0.750; Gln, His, Thr, Cit, Val, Ile, 0.764, 0.712, 0.7%, 0.740, 0.753; Gln, His, Thr, Tyr, Met, Ile, 0.764, 0.743, 5.5%, 0.757, 0.750; Gln, His, Tyr, Orn, Ile, Leu, 0.764, 0.728, 2.4%, 0.749, 0.767; Gln, His, Tyr, Val, Orn, Ile, 0.764, 0.727, 2.4% , 0.750, 0.773; Gln, His, Val, Ile, Leu, Phe, 0.764, 0.706, 0.0%, 0.729, 0.684; Gln, Tyr, Met, Lys, Ile, Leu, 0.764, 0.727, 4.0%, 0.720, 0.734 Gly, Ala, Arg, Tyr, Lys, Ile, 0.764, 0.709, 3.7%, 0.705, 0.736; Gly, Arg, Tyr, Orn, Lys, Ile, 0.764, 0.708, 3.9%, 0.705, 0.738; Gly, Gln , Arg, Lys, Ile, Phe, 0.764, 0.680, 1.3%, 0.666, 0.667; Gly, Gln, Cit, Tyr, Ile, Leu, 0.764, 0.723, 3.5%, 0.722, 0.730; Gly, Gln, His, Arg , Ile, Phe, 0.764, 0.701, 0.0%, 0.725, 0.680; Gly, Gln, His, Tyr, Leu, Trp, 0.764, 0.736, 5.1%, 0.724, 0.704; His, Ala, Tyr, Met, Ile, Phe , 0.764, 0.724, 2.0%, 0.726, 0.682; His, Arg, Tyr, Orn, Lys, Ile, 0.764, 0.709, 3.1%, 0.712, 0.738; His, Pro, Tyr, Met, Lys, Ile, 0.764, 0.725 , 6.4%, 0.713, 0.708; is, Thr, Tyr, Met, Ile, Phe, 0.764, 0.730, 2.2%, 0.732, 0.680; Ser, Arg, Tyr, Met, Lys, Ile, 0.764, 0.714, 4.4%, 0.709, 0.736; Ser, Asn, Gln, Tyr, Lys, Ile, 0.764, 0.709, 7.0%, 0.695, 0.718; Ala, Arg, Tyr, Met, Lys, Ile, 0.763, 0.719, 5.1%, 0.716, 0.740; Arg, Pro, Tyr, Met, Lys, Ile, 0.763, 0.715, 4.8%, 0.710, 0.728; Arg, Tyr, Met, Orn, Lys, Ile, 0.763, 0.719, 5.1%, 0.716, 0.740; Asn, Cit, Tyr, Lys, Ile, Phe, Asn, Gln, His, Ala, Arg, Ile, 0.763, 0.710, 1.5%, 0.736, 0.714; Asn, Gln, His, Tyr, Lys, Ile, 0.763, 0.730, 4.6%, 0.735, 0.742; Asn, Gln, His, Tyr, Orn, Leu, 0.763, 0.728, 1.1%, 0.735, 0.722; Asn, Gln, Lys, Ile, Leu, Phe, 0.763, 0.686, 0.4%, 0.662 , 0.639; Asn, Gln, Tyr, Ile, Phe, Trp, 0.763, 0.729, 7.0%, 0.741, 0.706; Asn, Gln, Tyr, Lys, Ile, Leu, 0.763, 0.720, 5.9%, 0.715, 0.710; , Gln, Tyr, Met, Lys, Ile, 0.763, 0.723, 6.4%, 0.714, 0.714; Asn, Gly, Arg, Lys, Ile, Leu, 0.763, 0.675, 1.8%, 0.659, 0.661; , Met, Lys, Leu, 0.763, 0.72 2, 3.1%, 0.692, 0.641; Asn, His, Thr, Lys, Ile, Phe, 0.763, 0.691, 1.3%, 0.670, 0.619; Asn, Tyr, Met, Lys, Ile, Leu, 0.763, 0.722, 6.2% , 0.702, 0.688; Gln, Arg, Lys, Ile, Leu, Trp, 0.763, 0.686, 0.9%, 0.682, 0.728; Gln, Cit, Arg, Lys, Ile, Phe, 0.763, 0.683, 1.1%, 0.681, 0.692 Gln, Cit, Tyr, Leu, Phe, Trp, 0.763, 0.734, 2.6%, 0.732, 0.690; Gln, Cit, Tyr, Orn, Ile, Phe, 0.763, 0.715, 3.9%, 0.733, 0.728; Gln, His , Ala, Cit, Arg, Ile, 0.763, 0.712, 0.9%, 0.736, 0.744; Gln, His, Arg, Ile, Leu, Phe, 0.763, 0.708, 0.0%, 0.730, 0.679; Gln, His, Arg, Tyr , Ile, Leu, 0.763, 0.734, 2.4%, 0.759, 0.783; Gln, His, Cit, Met, Ile, Trp, 0.763, 0.716, 1.7%, 0.735, 0.724; Gln, His, Pro, Tyr, Orn, Ile , 0.763, 0.728, 2.8%, 0.750, 0.777; Gln, His, Thr, Cit, Ile, Phe, 0.763, 0.704, 0.2%, 0.724, 0.702; Gln, His, Tyr, Val, Ile, Leu, 0.763, 0.731 , 2.4%, 0.752, 0.771; Gln, His, Val, Ile, Phe, Trp, 0.763, 0.709, 0.2%, 0.732, 0.692; Gln, Tyr, Lys, Ile, Phe, Trp, 0.763, 0.725, 7.2%, 0.718, 0.732; Gly, Arg, Tyr, Ly s, Ile, Leu, 0.763, 0.709, 2.9%, 0.702, 0.718; Gly, Gln, Arg, Lys, Ile, Trp, 0.763, 0.681, 1.1%, 0.667, 0.702; Phe, 0.763, 0.723, 6.6%, 0.728, 0.708; Gly, Gln, Tyr, Lys, Ile, Trp, 0.763, 0.719, 7.7%, 0.703, 0.748;

His, Cit, Arg, Tyr, Ile, Phe, 0.763, 0.722, 2.4%, 0.734, 0.704; His, Tyr, Met, Ile, Phe, Trp, 0.763, 0.727, 2.8%, 0.727, 0.671; Ser, Arg, Tyr, Orn, Lys, Ile, 0.763, 0.706, 3.3%, 0.704, 0.755; Ser, Arg, Tyr, Val, Lys, Ile, 0.763, 0.708, 3.3%, 0.703, 0.748; Ser, Asn, Arg, Lys, Ile, Leu, 0.763, 0.660, 2.2%, 0.648, 0.682; Ser, Asn, Arg, Lys, Ile, Phe, Ser, Asn, Cit, Tyr, Lys, Ile, 0.763, 0.708, 5.3%, 0.704, 0.726; Ser, Asn, Gln, Lys, Leu, Phe, 0.763, 0.671, Ser, Gln, Arg, Lys, Ile, Trp, 0.763, 0.666, 0.7%, 0.650, 0.704; Ser, Gln, His, Ala, Tyr, Ile, 0.763, 0.726, 2.8%, 0.746 , 0.773; Ser, Gln, His, Tyr, Orn, Ile, 0.763, 0.725, 2.8%, 0.748, 0.771; Ser, Gln, Tyr, Lys, Ile, Trp, 0.763, 0.708, 7.7%, 0.696, 0.763; , Gln, Tyr, Val, Ile, Phe, 0.763, 0.724, 5.5%, 0.730, 0.714; Arg, Tyr, Val, Lys, Ile, Trp, 0.763, 0.716, 7.4%, 0.704, 0.734; , Met, Lys, Ile, 0.763, 0.722 , 4.8%, 0.717, 0.742; Asn, Ala, Cit, Tyr, Lys, Ile, 0.763, 0.713, 5.7%, 0.709, 0.722; Asn, Arg, Orn, Lys, Ile, Phe, 0.763, 0.668, 2.2%, 0.662, 0.655; Asn, Gln, Arg, Tyr, Leu, Phe, 0.763, 0.737, 1.7%, 0.738, 0.675; Asn, Gln, His, Ala, Ile, Phe, 0.763, 0.703, 0.4%, 0.727, 0.673; Asn, Gln, His, Thr, Val, Ile, 0.763, 0.711, 1.7%, 0.740, 0.740; Asn, Gln, Thr, Tyr, Leu, Phe, 0.763, 0.738, 2.2%, 0.740, 0.679; Tyr, Lys, Leu, Trp, 0.763, 0.733, 3.5%, 0.715, 0.708; Asn, Gly, Cit, Lys, Ile, Leu, 0.763, 0.683, 1.1%, 0.664, 0.665; Asn, Gly, Gln, Ala, Tyr, Ile, 0.763, 0.729, 7.5%, 0.726, 0.710; Asn, Gly, Gln, His, Val, Ile, 0.763, 0.704, 1.3%, 0.728, 0.704; Asn, Gly, Gln, Lys, Leu, Phe, Asn, Gly, Gln, Thr, Lys, Leu, 0.763, 0.681, 0.2%, 0.645, 0.602; Asn, Thr, Arg, Lys, Ile, Phe, 0.763, 0.677, 1.8%, 0.670, 0.667; Gln, Ala, Tyr, Met, Ile, Phe, 0.763, 0.728, 6.1%, 0.740, 0.710; Gln, Arg, Tyr, Lys, Ile, Trp, 0.763, 0.728, 7.5%, 0.728 , 0.771; Gln, Cit, Arg, Orn , Lys, Ile, 0.763, 0.679, 1.5%, 0.677, 0.718; Gln, His, Ala, Cit, Ile, Phe, 0.763, 0.702, 0.4%, 0.725, 0.694; Gln, His, Ala, Pro, Tyr, Ile , 0.763, 0.732, 2.6%, 0.752, 0.777; Gln, His, Cit, Tyr, Ile, Leu, 0.763, 0.736, 2.4%, 0.761, 0.793; Gln, Pro, Tyr, Ile, Leu, Trp, 0.763, 0.737 , 6.2%, 0.733, 0.728; Gln, Thr, Arg, Lys, Ile, Phe, 0.763, 0.683, 0.9%, 0.678, 0.688; Gln, Tyr, Val, Leu, Phe, Trp, 0.763, 0.733, 2.6%, 0.728, 0.684; Gly, Gln, Cit, Pro, Orn, Ile, 0.763, 0.682, 1.3%, 0.684, 0.679; Gly, Gln, Cit, Tyr, Ile, Phe, 0.763, 0.719, 3.9%, 0.724, 0.710; Gly, Gln, His, Pro, Tyr, Ile, 0.763, 0.731, 3.1%, 0.747, 0.769; Gly, Gln, Pro, Tyr, Leu, Trp, 0.763, 0.728, 5.0%, 0.710, 0.700; Tyr, Met, Ile, Leu, 0.763, 0.724, 4.8%, 0.714, 0.698; His, Ala, Tyr, Met, Lys, Ile, 0.763, 0.724, 6.2%, 0.711, 0.708; His, Thr, Tyr, Lys, Ile, Phe, 0.763, 0.723, 2.9%, 0.723, 0.700; His, Tyr, Met, Orn, Lys, Ile, 0.763, 0.727, 5.7%, 0.711, 0.720; Ser, Arg, Tyr, Lys, Ile, Leu, 0.763, 0.707, 3.1%, 0.702, 0 Ser, Asn, Gly, Cit, Tyr, Ile, 0.763, 0.723, 6.4%, 0.725, 0.716; Ser, Gln, Ala, Tyr, Ile, Phe, 0.763, 0.714, 5.5%, 0.728, 0.720; Ser, Gln, Arg, Val, Lys, Ile, 0.763, 0.664, 0.6%, 0.659, 0.732; Ser, Gln, Tyr , Leu, Phe, Trp, 0.763, 0.733, 2.6%, 0.728, 0.686; Ser, Thr, Arg, Tyr, Lys, Ile, 0.763, 0.704, 7.0%, 0.703, 0.755; Arg, Tyr, Met, Lys, Ile , Leu, 0.762, 0.722, 4.0%, 0.715, 0.730; Asn, Arg, Lys, Ile, Leu, Phe, 0.762, 0.676, 1.7%, 0.667, 0.665; Asn, Gln, Arg, Lys, Ile, Leu, 0.762 , 0.681, 2.2%, 0.677, 0.706; Asn, Gln, Arg, Tyr, Ile, Leu, 0.762, 0.732, 3.3%, 0.740, 0.718; Asn, Gln, Arg, Val, Lys, Ile, 0.762, 0.679, 2.4 %, 0.680, 0.730; Asn, Gln, His, Arg, Ile, Leu, 0.762, 0.715, 0.9%, 0.739, 0.722; Asn, Gln, His, Tyr, Val, Orn, 0.762, 0.728, 3.3%, 0.728, 0.718; Asn, Gln, Thr, Arg, Lys, Ile, 0.762, 0.683, 2.0%, 0.680, 0.706; Asn, Gln, Thr, Lys, Leu, Phe, 0.762, 0.679, 0.0%, 0.649, 0.604; Gln, Val, Lys, Ile, Phe, 0.76 2, 0.676, 1.7%, 0.657, 0.665; Asn, Gly, Cit, Tyr, Met, Ile, 0.762, 0.726, 8.1%, 0.720, 0.708; Asn, Gly, Cit, Tyr, Orn, Ile, 0.762, 0.713, 6.2%, 0.719, 0.716; Asn, Gly, Cit, Tyr, Val, Ile, 0.762, 0.726, 6.4%, 0.722, 0.708; Asn, Gly, Gln, Cit, Tyr, Leu, 0.762, 0.726, 3.1%, 0.716 , 0.680; Asn, Gly, Gln, His, Lys, Ile, 0.762, 0.691, 2.2%, 0.676, 0.665; Asn, Gly, Gln, His, Orn, Ile, 0.762, 0.693, 1.8%, 0.713, 0.684; Asn, Gly, His, Cit, Tyr, Ile, 0.762, 0.722, 4.0%, 0.734, 0.732; Asn, His, Ala , Cit, Tyr, Ile, 0.762, 0.728, 3.7%, 0.744, 0.730; Asn, His, Arg, Orn, Lys, Ile, 0.762, 0.680, 1.5%, 0.681, 0.671; , Ile, 0.762, 0.731, 4.4%, 0.742, 0.718; Asn, His, Cit, Pro, Tyr, Ile, 0.762, 0.728, 3.9%, 0.744, 0.740; Asn, His, Tyr, Met, Ile, Leu, 0.762 Asn, Thr, Cit, Tyr, Lys, Ile, 0.762, 0.717, 7.5%, 0.711, 0.716; Gln, Ala, Tyr, Ile, Phe, Trp, 0.762, 0.729, 6.6 %, 0.739, 0.706; Arg, Lys, Ile, Trp, 0.762, 0.685, 0.7%, 0.680, 0.728; Gln, His, Ala, Arg, Ile, Phe, 0.762, 0.702, 0.2%, 0.723, 0.692; Gln, His, Ala, Cit, Ile, Leu, 0.762, 0.711, 0.9%, 0.735, 0.742; Gln, His, Cit, Pro, Met, Ile, 0.762, 0.710, 1.1%, 0.732, 0.726; Gln, His, Pro, Tyr, Leu, Trp, Gln, His, Tyr, Met, Ile, Leu, 0.762, 0.740, 5.0%, 0.753, 0.740; Gln, His, Tyr, Val, Met, Ile, 0.762, 0.741, 5.3%, 0.756, 0.746; Gln, Tyr, Met, Ile, Phe, Trp, 0.762, 0.730, 6.4%, 0.740, 0.704; Gln, Tyr, Orn, Ile, Phe, Trp, 0.762, 0.733, 6.6%, 0.744 Gly, Arg, Pro, Tyr, Lys, Ile, 0.762, 0.706, 4.2%, 0.700, 0.726; Gly, Gln, Arg, Tyr, Ile, Phe, 0.762, 0.720, 3.5%, 0.728, 0.704; , Gln, His, Cit, Pro, Ile, 0.762, 0.705, 1.3%, 0.720, 0.712; Gly, Gln, His, Tyr, Met, Leu, 0.762, 0.731, 3.1%, 0.729, 0.700; Gly, Gln, Tyr , Orn, Leu, Trp, 0.762, 0.727, 5.0%, 0.709, 0.698; Gly, Gln, Tyr, Val, Ile, Phe, 0.762, 0.723, 5.5%, 0.718, 0.698; Gly, His, Tyr, Met, Lys , Ile, 0.762, 0.720, 6.1%, Ser, Arg, Pro, Tyr, Lys, Ile, 0.762, 0.705, 4.6%, 0.703, 0.748; Ser, Asn, Gln, Tyr, Ile, Phe, 0.762, 0.719, 4.8%, 0.728, 0.712; Ser, Gln, Ala, Arg, Lys, Ile, 0.762, 0.666, 0.6%, 0.661, 0.722; Ser, Gln, His, Cit, Ile, Phe, 0.762, 0.691, 0.4%, 0.710, 0.692; Ser, Gly, Arg, Tyr, Lys, Ile, 0.762, 0.705, 3.5%, 0.700, 0.738; Ser, Gly, Gln, Tyr, Leu, Phe, 0.762, 0.731, 2.6%, 0.723, 0.673; Thr, Arg, Tyr, Met, Lys, Ile, 0.762, 0.723, 4.8%, 0.719, 0.738; Ala, Tyr, Met, Lys, Ile, Phe, 0.761, 0.717, 6.8%, 0.700, 0.688; Asn, Arg, Orn, Lys, Ile, Leu, 0.761, 0.668, 2.8%, 0.660, 0.665; Asn, Arg, Orn, Lys, Ile, Trp, 0.761, 0.666, 2.8%, 0.662, 0.669; Asn, Cit, Arg, Lys, Ile, Phe, 0.761, 0.676, 2.0%, 0.671, 0.671; Asn, Gln, Cit, Orn, Lys, Ile, 0.761, 0.678, 2.8%, 0.665 , 0.673; Asn, Gln, His, Ala, Met, Ile, 0.761, 0.708, 1.5%, 0.730, 0.704; Asn, Gln, His, Arg, Pro, Ile, 0.761, 0.713, 1.5%, 0.738, 0.720; , Gln, His, Pro, Met, I le, 0.761, 0.712, 1.3%, 0.737, 0.712; Asn, Gln, His, Pro, Orn, Ile, 0.761, 0.697, 2.4%, 0.720, 0.696; Asn, Gln, Pro, Tyr, Ile, Phe, 0.761, 0.731, 5.9%, 0.742, 0.706; Asn, Gln, Pro, Tyr, Leu, Phe, 0.761, 0.731, 2.4%, 0.732, 0.675; Asn, Gln, Tyr, Met, Ile, Phe, 0.761, 0.729, 6.2% , 0.742, 0.706; Asn, Gly, Cit, Pro, Lys, Ile, 0.761, 0.679, 1.7%, 0.664, 0.680; Asn, Gly, Cit, Val, Lys, Ile, 0.761, 0.682, 1.5%, 0.664, 0.671 Asn, Gly, Gln, Pro, Tyr, Leu, 0.761, 0.726, 3.7%, 0.715, 0.680; Asn, Gly, Gln, Tyr, Val, Ile, 0.761, 0.723, 6.6%, 0.715, 0.708; Asn, Gly , His, Cit, Lys, Ile, 0.761, 0.691, 3.9%, 0.682, 0.661; Asn, His, Arg, Tyr, Met, Ile, 0.761, 0.736, 2.9%, 0.748, 0.718; , Tyr, Ile, 0.761, 0.732, 3.5%, 0.752, 0.734; Asn, His, Cit, Lys, Ile, Phe, 0.761, 0.689, 1.1%, 0.674, 0.637; Asn, His, Cit, Tyr, Ile, Leu Asn, His, Cit, Tyr, Lys, Ile, 0.761, 0.714, 4.8%, 0.715, 0.722; Cit, Arg, Tyr, Lys, Ile, Trp, 0.761, 0.718 , 5.1%, 0.712, 0.740; n, His, Ala, Cit, Ile, Trp, 0.761, 0.709, 1.3%, 0.727, 0.722; Gln, His, Ala, Pro, Ile, Trp, 0.761, 0.710, 1.8%, 0.728, 0.716; Ala, Tyr, Ile, Leu, 0.761, 0.732, 2.4%, 0.751, 0.769; Gln, His, Ala, Tyr, Leu, Trp, 0.761, 0.731, 3.3%, 0.727, 0.730; Gln, His, Arg, Tyr, Met, Ile, 0.761, 0.739, 5.0%, 0.760, 0.753; Gln, His, Cit, Arg, Val, Ile, 0.761, 0.713, 0.7%, 0.737, 0.736; Gln, His, Cit, Lys, Ile, Phe, Gln, His, Thr, Arg, Ile, Phe, 0.761, 0.704, 0.0%, 0.730, 0.702; Gln, His, Thr, Cit, Tyr, Ile, 0.761, 0.734, 2.6%, 0.761, 0.793; Gln, Pro, Tyr, Met, Ile, Phe, 0.761, 0.731, 5.3%, 0.743, 0.708; Gln, Pro, Tyr, Met, Leu, Phe, 0.761, 0.731, 3.3%, 0.732 , 0.684; Gln, Thr, Ala, Tyr, Ile, Phe, 0.761, 0.728, 6.2%, 0.740, 0.708; Gln, Thr, Tyr, Met, Ile, Phe, 0.761, 0.730, 6.4%, 0.743, 0.708; , Tyr, Met, Ile, Leu, Trp, 0.761, 0.735, 5.3%, 0.731, 0.718; Gln, Tyr, Orn, Lys, Ile, Phe, 0.761, 0.728, 5.3%, 0.722, 0.730; , Met, Ile, Phe, 0.761, 0.733 , 5.7%, 0.736, 0.702; Gly, Gln, Ala, Tyr, Ile, Leu, 0.761, 0.723, 3.7%, 0.721, 0.724; Gly, Gln, Ala, Tyr, Leu, Phe, 0.761, 0.717, 2.2%, 0.711, 0.679; Gly, Gln, Ala, Tyr, Leu, Trp, 0.761, 0.728, 5.0%, 0.711, 0.696; Gly, Gln, Arg, Tyr, Lys, Leu, 0.761, 0.722, 2.2%, 0.713, 0.720; Gly, Gln, Cit, Tyr, Ile, Trp, 0.761, 0.726, 5.5%, 0.724, 0.744; Gly, Gln, Cit, Tyr, Leu, Phe, 0.761, 0.720, 2.2%, 0.710, 0.684; Cit, Tyr, Lys, Leu, 0.761, 0.721, 2.9%, 0.711, 0.728; Gly, His, Cit, Tyr, Ile, Phe, 0.761, 0.713, 2.8%, 0.713, 0.710; Pro, Tyr, Met, Lys, Ile, Phe, 0.761, 0.716, 7.9%, 0.697, 0.677; Ser, Gln, His, Tyr, Ile, Leu, 0.761, 0.725, 2.8%, 0.745, 0.769; Ser, Gly, Gln, Arg, Lys, Ile, Ser, His, Tyr, Met, Lys, Ile, 0.761, 0.722, 6.4%, 0.709, 0.704; Thr, Arg, Tyr, Lys, Ile, Trp, 0.761, 0.719, 8.5%, 0.707, 0.732; Arg, Tyr, Ile, Leu, Phe, Trp, 0.761, 0.724, 3.1%, 0.720, 0.663; Arg, Tyr, Val, Orn, Lys, Ile, 0.761, 0.712, 4.0%, 0.709 , 0.736; Asn, Ala, Arg, Lys , Ile, Phe, 0.761, 0.669, 2.0%, 0.665, 0.669; Asn, Arg, Met, Lys, Ile, Phe, 0.761, 0.676, 1.7%, 0.665, 0.655; Asn, Arg, Val, Orn, Lys, Ile , 0.761, 0.662, 3.5%, 0.658, 0.673; Asn, Cit, Arg, Pro, Tyr, Lys, 0.761, 0.705, 6.6%, 0.692, 0.744;

Asn, Gln, His, Arg, Orn, Ile, 0.761, 0.697, 1.1%, 0.723, 0.696; Asn, Gln, His , Lys, Ile, Leu, 0.761, 0.698, 2.9%, 0.697, 0.716; Asn, Gln, His, Orn, Ile, Leu, 0.761, 0.697, 2.4%, 0.717, 0.692; , Leu, 0.761, 0.711, 1.5%, 0.734, 0.716; Asn, Gln, His, Thr, Met, Ile, 0.761, 0.712, 1.1%, 0.735, 0.716; Asn, Gln, His, Thr, Tyr, Leu, 0.761 , 0.741, 2.0%, 0.744, 0.718; Asn, Gln, Tyr, Met, Ile, Leu, 0.761, 0.735, 5.9%, 0.735, 0.694; Asn, Gln, Tyr, Orn, Leu, Trp, 0.761, 0.727, 5.0 %, 0.718, 0.698; Asn, Gln, Tyr, Orn, Lys, Leu, 0.761, 0.722, 2.6%, 0.710, 0.710; Asn, Gly, Arg, Met, Lys, Ile, 0.761, 0.674, 1.7%, 0.660, 0.669; Asn, Gly, Gln, His, Ala, Ile, 0.761, 0.703, 1.3%, 0.724, 0.696; Asn, Gly, Gln, His, Ile, Leu, 0.761, 0.706, 1.1%, 0.725, 0.698; Gly, Gly, Orn, Lys, Ile, 0.761, 0.678, 2.4%, 0.650, 0.663; Asn, Gly, Gln, Orn, Lys, Leu, 0.761, 0.670, 0.2%, 0.635, 0.600; Tyr, Val, Leu, 0.761, 0.723, 2.8%, 0.715, 0.673; Asn, Gly, Thr, Cit, Lys, Ile, 0.761, 0.681, 1.5%, 0.663, 0.671; Asn, Gly, Thr, Cit, Tyr, Ile, 0.761, 0.724, 8.1%, 0.727 , 0.708; Asn, His, Arg, Tyr, Orn, Ile, 0.761, 0.723, 3.3%, 0.741, 0.718; Asn, His, Cit, Pro, Lys, Ile, 0.761, 0.690, 4.2%, 0.685, 0.694; , His, Lys, Ile, Leu, Phe, 0.761, 0.688, 1.5%, 0.669, 0.621; Asn, His, Met, Lys, Ile, Phe, 0.761, 0.687, 1.5%, 0.667, 0.613; , Lys, Leu, Phe, 0.761, 0.733, 3.7%, 0.714, 0.655; Gln, Ala, Tyr, Lys, Ile, Phe, 0.761, 0.720, 5.1%, 0.714, 0.726; Gln, Cit, Tyr, Orn, Leu , Trp, 0.761, 0.717, 3.5%, 0.711, 0.698; Gln, His, Cit, Met, Ile, Leu, 0.761, 0.711, 0.7%, 0.735, 0.730; Gln, His, Cit, Tyr, Val, Ile, 0.761 , 0.735, 2.6%, 0.760, 0.799; Gln, His, Thr, Ala, Tyr, Ile, 0.761, 0.737, 3.3%, 0.757, 0.771; Gln, His, Tyr, Val, Leu, Trp, 0.761, 0.736, 3.5 %, 0.726, 0.718; Gln, Thr, Tyr, Orn, Leu, Phe, 0.761, 0.725, 2.4%, 0.732, 0.682; Gln, Thr, Tyr, Val, Ile, Phe, 0.761, 0.735, 6.2%, 0.740, 0.700; Gln, Tyr, Met, Leu, Phe, Trp, 0.761, 0.734, 2.8%, 0.729, 0.677; Gln, Tyr, Val, Lys, Leu, Phe, 0.761, 0.723, 1.5%, 0.719, 0.700; Gly, Gln, Arg, Orn, Lys, Ile, Gly, Gln, His, Cit, Tyr, Leu, 0.761, 0.724, 1.8%, 0.719, 0.730; Gly, Gln, His, Orn, Ile, Phe, 0.761, 0.692, 0.4%, 0.712, 0.677; Gly, Gln, His, Tyr, Ile, Leu, 0.761, 0.729, 2.9%, 0.743, 0.744; Gly, Gln, His, Tyr, Lys, Leu, 0.761, 0.723, 2.9%, 0.708 , 0.730; Gly, Gln, His, Tyr, Val, Leu, 0.761, 0.726, 2.4%, 0.721, 0.736; Gly, Gln, Tyr, Val, Ile, Leu, 0.761, 0.720, 3.7%, 0.720, 0.724; , His, Arg, Tyr, Ile, Phe, 0.761, 0.717, 3.5%, 0.726, 0.692; Gly, His, Tyr, Met, Ile, Phe, 0.761, 0.723, 2.4%, 0.721, 0.677; , Lys, Ile, Phe, 0.761, 0.714, 7.7%, 0.692, 0.679; His, Arg, Pro, Tyr, Ile, Phe, 0.761, 0.723, 3.3%, 0.733, 0.694; His, Arg, Tyr, Ile, Leu , Phe, 0.761, 0.723, 2.8%, 0.730, 0.690; His, Cit, Tyr, Met, Ile, Phe, 0.761, 0.724, 2.6%, 0.730, 0.702; His, Tyr, Met, Orn, Ile, Phe, 0.761 , 0.729, 2.6%, 0.727, 0. 679; Ser, Ala, Arg, Tyr, Lys, Ile, 0.761, 0.706, 3.3%, 0.703, 0.753; Ser, Asn, Arg, Orn, Lys, Ile, 0.761, 0.658, 3.3%, 0.649, 0.684; Cit, Arg, Tyr, Lys, Ile, 0.761, 0.707, 2.8%, 0.709, 0.753; Ser, Gln, Cit, Arg, Lys, Ile, 0.761, 0.669, 0.4%, 0.660, 0.714; Ser, Gln, His, Tyr, Val, Ile, 0.761, 0.725, 2.8%, 0.747, 0.769; Ser, Gly, Gln, Tyr, Lys, Ile, 0.761, 0.711, 5.0%, 0.701, 0.746; Tyr, Met, Lys, Ile, Phe, Trp, 0.761, 0.718, 7.7%, 0.700, 0.680; Asn, Arg, Val, Lys, Ile, Phe, 0.760, 0.671, 2.0%, 0.662, 0.661; Asn, Cit, Arg, Orn, Lys, Ile, 0.760, Asn, Cit, Pro, Orn, Lys, Ile, 0.760, 0.672, 1.8%, 0.659, 0.667; Asn, Cit, Tyr, Val, Lys, Ile, 0.760, 0.715, 5.7% , 0.712, 0.728; Asn, Cit, Val, Lys, Ile, Leu, 0.760, 0.682, 1.5%, 0.670, 0.677; Asn, Gln, Cit, Val, Lys, Ile, 0.760, 0.680, 1.8%, 0.671, 0.706 Asn, Gln, Orn, Lys, Ile, Phe, 0.760, 0.677, 1.3%, 0.656, 0.649; Asn, Gln, Pro, Tyr, Lys, Ile, 0.760, 0.722, 6.6%, 0.716, 0.716; Asn, Gln , Thr, Tyr, Ile, Phe, 0.760 , 0.731, 6.1%, 0.744, 0.704; Asn, Gln, Tyr, Val, Ile, Leu, 0.760, 0.728, 3.3%, 0.735, 0.712; Asn, Gly, Arg, Pro, Tyr, Lys, 0.760, 0.705, 6.6 %, 0.690, 0.740; Asn, Gly, Cit, Tyr, Lys, Ile, 0.760, 0.707, 7.4%, 0.696, 0.710; Asn, Gly, Gln, Arg, Lys, Ile, 0.760, 0.677, 2.8%, 0.661, 0.669; Asn, Gly, Gln, Cit, Lys, Ile, 0.760, 0.681, 1.3%, 0.658, 0.663; Asn, Gly, Gln, Lys, Ile, Trp, 0.760, 0.678, 2.0%, 0.653, 0.665; Gly, His, Arg, Tyr, Ile, 0.760, 0.724, 5.0%, 0.732, 0.696; Asn, His, Ala, Cit, Lys, Ile, 0.760, 0.694, 3.3%, 0.690, 0.702; Asn, His, Cit, Met, Lys, Ile, 0.760, 0.693, 2.8%, 0.682, 0.651; Asn, His, Cit, Orn, Lys, Ile, 0.760, 0.684, 5.0%, 0.678, 0.659; Asn, His, Cit, Tyr, Val, Ile, 0.760, 0.727, 3.5%, 0.742, 0.734; Asn, His, Tyr, Met, Ile, Phe, 0.760, 0.730, 2.9%, 0.735, 0.671; Asn, Thr, Arg, Orn, Lys, Ile, 0.760, Cit, Arg, Tyr, Met, Lys, Ile, 0.760, 0.720, 4.2%, 0.718, 0.740; Gln, Arg, Val, Orn, Lys, Ile, 0.760, 0.673, 0.9% , 0.675, 0.728; Gln, Cit, T yr, Orn, Ile, Leu, 0.760, 0.715, 3.1%, 0.728, 0.746; Gln, His, Ala, Val, Met, Ile, 0.760, 0.707, 0.6%, 0.727, 0.718; Gln, His, Arg, Tyr, Lys, Ile, 0.760, 0.726, 2.6%, 0.742, 0.785; Gln, His, Cit, Ile, Leu, Trp, 0.760, 0.714, 0.9%, 0.730, 0.718; Gln, His, Cit, Orn, Lys, Ile, Gln, His, Thr, Ala, Cit, Ile, 0.760, 0.710, 0.9%, 0.735, 0.744; Gln, His, Tyr, Lys, Leu, Trp, 0.760, 0.730, 3.5%, 0.716, 0.724; Gln, His, Val, Lys, Ile, Phe, 0.760, 0.692, 0.7%, 0.691, 0.692; Gln, His, Val, Met, Ile, Phe, 0.760, 0.707, 0.2%, 0.729 , 0.690; Gln, Pro, Tyr, Val, Ile, Phe, 0.760, 0.733, 5.7%, 0.736, 0.698; Gln, Thr, Tyr, Ile, Phe, Trp, 0.760, 0.730, 7.0%, 0.741, 0.706; , Gln, Ala, Cit, Tyr, Ile, 0.760, 0.727, 4.0%, 0.733, 0.753; Gly, Gln, Arg, Tyr, Leu, Phe, 0.760, 0.723, 2.0%, 0.718, 0.680; , Tyr, Met, Ile, 0.760, 0.724, 5.1%, 0.723, 0.734; Gly, Gln, His, Ile, Leu, Phe, 0.760, 0.701, 0.0%, 0.718, 0.669; Gly, Gln, His, Ile, Phe , Trp, 0.760, 0.703, 0.2%, 0 .723, 0.677; Gly, Gln, Tyr, Met, Ile, Trp, 0.760, 0.730, 6.6%, 0.725, 0.720; His, Arg, Orn, Lys, Ile, Phe, 0.760, 0.671, 0.4%, 0.656, 0.645 His, Thr, Arg, Tyr, Ile, Phe, 0.760, 0.728, 3.1%, 0.744, 0.706; Ser, Asn, Arg, Lys, Ile, Trp, 0.760, 0.656, 3.1%, 0.643, 0.677; Ser, Asn , Gln, Arg, Lys, Ile, 0.760, 0.663, 2.4%, 0.653, 0.690; Ser, Asn, Gln, His, Val, Ile, 0.760, 0.692, 0.4%, 0.718, 0.740; Ser, Asn, Thr, Arg, Lys, Ile, 0.760, 0.655, 3.1%, 0.642, 0.679; Ser, Gln, Arg, Orn, Lys, Ile Ser, Gln, His, Thr, Tyr, Ile, 0.760, 0.725, 3.5%, 0.748, 0.775; Ser, Gln, Thr, Arg, Lys, Ile, 0.760, 0.668 , 0.4%, 0.659, 0.720; Ser, Gln, Tyr, Orn, Leu, Trp, 0.760, 0.722, 4.4%, 0.712, 0.714; Ser, Gly, Gln, Tyr, Ile, Leu, 0.760, 0.720, 3.3%, Arg, Tyr, Lys, Ile, Leu, Trp, 0.759, 0.716, 6.4%, 0.703, 0.722; Arg, Tyr, Orn, Lys, Ile, Trp, 0.759, 0.714, 7.4%, 0.703, 0.728; Asn, Ala, Cit, Lys, Ile, Le u, 0.759, 0.681, 1.5%, 0.672, 0.692; Asn, Arg, Pro, Tyr, Orn, Lys, 0.759, 0.693, 8.3%, 0.688, 0.748; Asn, Gln, Ala, Tyr, Lys, Leu, 0.759, 0.723, 2.9%, 0.713, 0.714; Asn, Gln, His, Arg, Met, Ile, 0.759, 0.713, 0.9%, 0.736, 0.718; Asn, Gln, His, Lys, Ile, Trp, 0.759, 0.699, 2.2% , 0.691, 0.677; Asn, Gln, His, Lys, Leu, Phe, 0.759, 0.691, 0.0%, 0.673, 0.643; Asn, Gln, His, Met, Ile, Leu, 0.759, 0.713, 0.9%, 0.735, 0.714 Asn, Gln, Lys, Ile, Phe, Trp, 0.759, 0.680, 1.7%, 0.660, 0.651; Asn, Gln, Orn, Lys, Leu, Phe, 0.759, 0.670, 0.2%, 0.637, 0.594; Asn, Gly , Gln, His, Arg, Ile, 0.759, 0.706, 1.1%, 0.729, 0.702; Asn, Gly, Gln, Lys, Ile, Phe, 0.759, 0.674, 1.5%, 0.649, 0.635; , Ile, Phe, 0.759, 0.688, 1.7%, 0.671, 0.633; Asn, Gly, Thr, Arg, Lys, Ile, 0.759, 0.674, 2.0%, 0.659, 0.667; Asn, Gly, Tyr, Met, Lys, Ile , 0.759, 0.713, 9.6%, 0.682, 0.680; Asn, His, Arg, Orn, Ile, Phe, 0.759, 0.685, 0.6%, 0.694, 0.633; Asn, His, Arg, Pro, Tyr, Ile, 0.759, 0.735 , 3.9%, 0.748, 0.722; , His, Cit, Val, Lys, Ile, 0.759, 0.690, 4.4%, 0.685, 0.684; Asn, Thr, Cit, Pro, Lys, Ile, 0.759, 0.682, 2.2%, 0.666, 0.690; , Met, Lys, Ile, 0.759, 0.717, 9.4%, 0.698, 0.692; Gln, Ala, Pro, Tyr, Ile, Phe, 0.759, 0.726, 4.6%, 0.738, 0.710; Gln, Arg, Orn, Lys, Ile , Leu, 0.759, 0.681, 1.1%, 0.677, 0.712; Gln, Arg, Tyr, Ile, Leu, Trp, 0.759, 0.735, 5.5%, 0.734, 0.730; Gln, His, Ala, Arg, Ile, Trp, 0.759 , 0.710, 1.7%, 0.732, 0.720; Gln, His, Ala, Cit, Val, Ile, 0.759, 0.710, 0.7%, 0.737, 0.740; Gln, His, Ala, Ile, Phe, Trp, 0.759, 0.701, 0.4 %, 0.716, 0.684; Gln, His, Ala, Met, Ile, Trp, 0.759, 0.709, 1.1%, 0.727, 0.714; Gln, His, Ala, Pro, Met, Ile, 0.759, 0.708, 1.1%, 0.728, 0.718; Gln, His, Arg, Val, Lys, Ile, 0.759, 0.694, 0.7%, 0.711, 0.753; Gln, His, Cit, Arg, Ile, Leu, 0.759, 0.712, 0.7%, 0.737, 0.734; His, Cit, Arg, Tyr, Ile, 0.759, 0.734, 2.4%, 0.761, 0.791; Gln, His, Cit, Val, Ile, Trp, 0.759, 0.714, 0.9%, 0.732, 0.720; Tyr, Ile, Leu, 0.759, 0.730, 2.4%, 0.748, 0.771; Gln, His, Thr, Ala, Met, Ile, 0.759, 0.705, 0.7%, 0.724, 0.720; Gln, His, Thr, Cit, Ile, Leu, 0.759, 0.711, 0.7%, 0.737 , 0.746; Gln, His, Thr, Tyr, Ile, Leu, 0.759, 0.733, 3.7%, 0.750, 0.765; Gln, His, Tyr, Met, Lys, Ile, 0.759, 0.734, 4.0%, 0.738, 0.753; , Thr, Pro, Tyr, Ile, Phe, 0.759, 0.730, 6.1%, 0.744, 0.710; Gln, Thr, Tyr, Lys, Leu, Phe, 0.759, 0.730, 2.0%, 0.725, 0.706; Gln, Tyr, Met Gln, Tyr, Met, Orn, Ile, Phe, 0.759, 0.732, 5.7%, 0.741, 0.702; Gly, Gln, Ala, Tyr, Ile , Trp, 0.759, 0.731, 7.4%, 0.726, 0.738; Gly, Gln, Cit, Tyr, Orn, Ile, 0.759, 0.708, 3.1%, 0.714, 0.740; Gly, Gln, His, Ala, Tyr, Ile, 0.759 , 0.731, 3.1%, 0.739, 0.757; Gly, Gln, Pro, Tyr, Ile, Trp, 0.759, 0.728, 6.2%, 0.725, 0.746; Gly, Gln, Tyr, Ile, Leu, Trp, 0.759, 0.728, 5.1 %, 0.711, 0.706; Gly, Gln, Tyr, Met, Lys, Leu, 0.759, 0.724, 2.4%, 0.704, 0.694; Gly, Gln, Tyr, Val, Lys, Ile, 0.759, 0.712, 5.0%, 0.703, 0.746; Gly, Gln, Tyr, Val, Lys, Trp, 0.759, 0.730, 6.6%, 0.703, 0.718; Gly, Gln, Tyr, Val, Met, Ile, 0.759, 0.730, 5.3%, 0.722, 0.714; His, Cit, Tyr, Ile, Phe, Trp, His, Pro, Tyr, Met, Ile, Phe, 0.759, 0.725, 2.4%, 0.724, 0.673; His,

Thr, Tyr, Ile, Phe, Trp, 0.759, 0.726, 3.7%, 0.728, 0.671; His, Tyr, Met, Lys, Ile, Trp, 0.759, 0.723, 6.6%, 0.712, 0.702; Ser, Asn, His, Tyr, Met, Ile, 0.759, 0.729, 3.7%, 0.736, 0.708; Ser, Asn, Tyr, Met, Lys, Ile, 0.759, 0.712, 8.1%, 0.688, 0.698; Ser, Gln, Arg, Tyr, Ile, Phe, 0.759, 0.717, 4.4%, 0.733, 0.724; Ser, His, Arg, Tyr, Ile, Phe, 0.759, 0.720, 3.5%, 0.730, 0.696; Arg, Pro, Tyr, Orn, Lys, Ile, 0.759, 0.707, 5.0%, 0.707, 0.742; Arg, Tyr, Orn, Lys, Ile, Leu, 0.759, 0.710, 3.7%, 0.708, 0.734; Asn, Arg, Tyr, Met, Lys, Leu, 0.759, 0.729, 3.5% , 0.717, 0.686; Asn, Gln, Ala, Cit, Lys, Ile, 0.759, 0.684, 1.5%, 0.676, 0.704; Asn, Gln, Ala, Tyr, Ile, Phe, 0.759, 0.726, 6.1%, 0.738, 0.708 Asn, Gln, Cit, Lys, Leu, Phe, 0.759, 0.677, 0.0%, 0.647, 0.607; Asn, Gln, His, Orn, Ile, Trp, 0.759, 0.698, 2.2%, 0.718, 0.688; Asn, Gln , His, Orn, Lys, Ile, 0.759, 0.690, 2.6%, 0.682, 0.671; Asn, Gln, His, Pro, Ile, Trp, 0.759, 0.709, 1.8%, 0.733, 0.708; , Pro, Ile, 0.759, 0.710, 1 Asn, Gln, His, Tyr, Lys, Leu, 0.759, 0.731, 3.5%, 0.725, 0.726; Asn, Gln, His, Tyr, Val, Leu, 0.759, 0.735, 1.1%, Asn, Gln, Val, Lys, Leu, Phe, 0.759, 0.677, 0.0%, 0.647, 0.607; Asn, Gly, Arg, Lys, Ile, Trp, 0.759, 0.673, 2.2%, 0.657, 0.663; Asn, Gly, Cit, Arg, Lys, Ile, 0.759, 0.674, 2.2%, 0.662, 0.667; Asn, Gly, Cit, Arg, Tyr, Ile, 0.759, 0.727, 5.9%, 0.727, 0.718; Asn, Gly, Tyr, Lys, Leu, Phe, 0.759, 0.714, 2.2%, 0.686, 0.617; Asn, His, Cit, Lys, Ile, Leu, 0.759, 0.693, 3.9%, 0.690, 0.684; Asn, Pro, Tyr, Lys, Leu, Phe, 0.759, 0.718, 2.0%, 0.696, 0.635; Asn, Thr, Cit, Tyr, Leu, Phe, 0.759, 0.733, 2.8%, 0.731, 0.667; Asn, Thr, Tyr, Lys, Ile, Phe, Asn, Tyr, Met, Lys, Ile, Trp, 0.759, 0.716, 8.1%, 0.695, 0.696; Cit, Tyr, Lys, Ile, Leu, Trp, 0.759, 0.716, 4.4%, 0.702, 0.716; Cit, Tyr, Met, Lys, Ile, Phe, 0.759, 0.716, 5.3%, 0.708, 0.704; Gln, Ala, Arg, Lys, Ile, Phe, 0.759, 0.675, 1.1%, 0.679 , 0.706; Gln, Ala, Tyr, Ile, L eu, Phe, 0.759, 0.724, 2.8%, 0.734, 0.704; Gln, Ala, Tyr, Lys, Leu, Phe, 0.759, 0.721, 2.2%, 0.719, 0.700; Gln, Arg, Tyr, Orn, Lys, Ile, Gln, Arg, Val, Lys, Ile, Leu, 0.759, 0.682, 1.1%, 0.685, 0.734; Gln, Cit, Tyr, Lys, Ile, Trp, 0.759, 0.723, 4.4%, 0.725, 0.783; Gln, His, Ala, Orn, Ile, Phe, 0.759, 0.690, 0.6%, 0.706, 0.679; Gln, His, Ala, Val, Ile, Trp, 0.759, 0.710, 1.8%, 0.728 , 0.718; Gln, His, Cit, Arg, Met, Ile, 0.759, 0.710, 0.7%, 0.731, 0.724; Gln, His, Cit, Val, Ile, Leu, 0.759, 0.712, 0.7%, 0.738, 0.736; , His, Cit, Val, Met, Ile, 0.759, 0.711, 0.7%, 0.735, 0.724; Gln, His, Met, Ile, Leu, Phe, 0.759, 0.706, 0.2%, 0.725, 0.684; Gln, His, Orn , Ile, Leu, Phe, 0.759, 0.694, 0.2%, 0.711, 0.669; Gln, His, Orn, Ile, Phe, Trp, 0.759, 0.695, 0.6%, 0.713, 0.675; Gln, His, Pro, Tyr, Val , Ile, 0.759, 0.730, 2.6%, 0.750, 0.777; Gln, His, Thr, Tyr, Lys, Ile, 0.759, 0.726, 5.1%, 0.734, 0.765; Gln, His, Thr, Tyr, Val, Ile, 0.759 , 0.733, 3.7%, 0.752, 0.76 7; Gln, His, Tyr, Met, Lys, Leu, 0.759, 0.734, 1.7%, 0.730, 0.724; Gln, His, Tyr, Val, Orn, Trp, 0.759, 0.728, 3.9%, 0.722, 0.736; His, Val, Orn, Ile, Phe, 0.759, 0.693, 0.4%, 0.713, 0.684; Gln, Pro, Tyr, Orn, Ile, Phe, 0.759, 0.731, 5.5%, 0.743, 0.706; Leu, Phe, Trp, 0.759, 0.735, 2.8%, 0.733, 0.684; Gln, Thr, Tyr, Orn, Ile, Phe, 0.759, 0.730, 5.9%, 0.741, 0.704; Gln, Tyr, Val, Met, Lys, Ile, 0.759, 0.723, 5.1%, 0.718, 0.748; Gln, Tyr, Val, Orn, Ile, Phe, 0.759, 0.734, 5.7%, 0.736, 0.702; 0.715, 5.7%, 0.704, 0.746; Gly, Gln, Arg, Lys, Ile, Leu, 0.759, 0.678, 1.1%, 0.668, 0.702; Gly, Gln, Cit, Tyr, Val, Ile, 0.759, 0.722, 4.0% , 0.723, 0.732; Gly, Gln, His, Ala, Tyr, Leu, 0.759, 0.724, 2.2%, 0.721, 0.732; Gly, Gln, Pro, Tyr, Ile, Leu, 0.759, 0.721, 3.1%, 0.718, 0.728 Gly, Gln, Pro, Tyr, Lys, Ile, 0.759, 0.714, 4.2%, 0.705, 0.748; Gly, Gln, Thr, Tyr, Lys, Ile, 0.759, 0.715, 5.3%, 0.702, 0.734; Gly, Gln , Tyr, Val, Leu, Trp, 0.759, 0.728, 5.1%, 0.707, 0.698; Gly, His, Tyr, Met, Ile, Trp, 0.759, 0.724, 4.2%, 0.718, 0.688; His, Ala, Arg, Tyr, Ile, Phe, 0.759, 0.716, 2.9% His, Ala, Cit, Tyr, Ile, Phe, 0.759, 0.712, 2.4%, 0.721, 0.718; His, Arg, Tyr, Ile, Phe, Trp, 0.759, 0.721, 4.2%, 0.731, 0.677 His, Cit, Arg, Tyr, Met, Ile, 0.759, 0.730, 3.9%, 0.740, 0.734; His, Pro, Tyr, Met, Ile, Trp, 0.759, 0.728, 4.4%, 0.728, 0.702; His, Thr , Ala, Tyr, Ile, Phe, 0.759, 0.722, 3.3%, 0.733, 0.688; His, Tyr, Met, Lys, Ile, Leu, 0.759, 0.722, 5.5%, 0.706, 0.704; Ser, Arg, Lys, Ile, Phe, Trp, 0.759, 0.656, 1.3%, 0.637, 0.665; Ser, Asn, Cit, Tyr, Orn, Ile Ser, Asn, Gln, His, Arg, Ile, 0.759, 0.695, 0.2%, 0.717, 0.724; Ser, Asn, Gly, Arg, Lys, Ile, 0.759, 0.657 , 2.8%, 0.645, 0.677; Ser, Asn, His, Arg, Tyr, Ile, 0.759, 0.720, 3.5%, 0.735, 0.716; Ser, Asn, His, Cit, Tyr, Ile, 0.759, 0.722, 3.9%, 0.738, 0.744; Ser, Gln, His , Arg, Ile, Phe, 0.759, 0.690, 0.4%, 0.710, 0.692; Ser, Gln, His, Cit, Tyr, Ile, 0.759, 0.726, 2.0%, 0.751, 0.797; Ser, Gln, Tyr, Lys, Ile, Leu, 0.759, 0.711, 3.9%, 0.706, 0.757; Ser, Gly, Gln, Tyr, Ile, Trp, 0.759 , 0.712, 6.6%, 0.710, 0.750; Ser, Gly, Gln, Tyr, Leu, Trp, 0.759, 0.730, 4.6%, 0.713, 0.694; Ser, His, Thr, Tyr, Ile, Phe, 0.759, 0.717, 2.6 %, 0.724, 0.680; Thr, Tyr, Orn, Lys, Ile, Phe, 0.759, 0.724, 5.1%, 0.714, 0.698; Asn, Ala, Cit, Tyr, Ile, Phe, 0.758, 0.724, 4.6%, 0.734, 0.694; Asn, Ala, Tyr, Met, Lys, Ile, 0.758, 0.717, 8.3%, 0.696, 0.694; Asn, Arg, Tyr, Orn, Lys, Leu, 0.758, 0.711, 3.5%, 0.705, 0.692; Cit, Lys, Ile, Leu, Phe, 0.758, 0.685, 1.5%, 0.667, 0.647; Asn, Cit, Lys, Ile, Leu, Trp, 0.758, 0.682, 1.5%, 0.670, 0.673; Asn, Cit, Pro, Lys, Ile, Phe, 0.758, 0.678, 2.6%, 0.661, 0.667; Asn, Cit, Pro, Met, Lys, Ile, 0.758, 0.680, 1.8%, 0.665, 0.686; Asn, Cit, Pro, Tyr, Lys, Ile, 0.758, 0.708, 5.5%, 0.7 05, 0.728; Asn, Cit, Tyr, Orn, Ile, Phe, 0.758, 0.717, 5.3%, 0.724, 0.690; Asn, Gln, Cit, Arg, Lys, Ile, 0.758, 0.680, 2.0%, 0.675, 0.704; Asn, Gln, Cit, Tyr, Ile, Phe, 0.758, 0.729, 4.0%, 0.745, 0.714; Asn, Gln, His, Met, Ile, Trp, 0.758, 0.710, 1.5%, 0.730, 0.710; His, Thr, Arg, Ile, 0.758, 0.710, 1.5%, 0.737, 0.724; Asn, Gln, His, Thr, Lys, Ile, 0.758, 0.698, 2.6%, 0.693, 0.682; Asn, Gln, Tyr, Met, Lys, Leu, 0.758, 0.729, 2.6%, 0.719, 0.694; Asn, Gly, Cit, Tyr, Ile, Trp, 0.758, 0.724, 7.4%, 0.723, 0.716; Asn, Gly, Gln, Ala, Lys, Ile, Asn, Gly, Gln, Arg, Tyr, Leu, 0.758, 0.724, 3.5%, 0.715, 0.680; Asn, Gly, Gln, His, Tyr, Val, 0.758, 0.736, 4.4%, 0.729, 0.716; Asn, Gly, Gln, Tyr, Ile, Phe, 0.758, 0.721, 5.7%, 0.722, 0.700; Asn, Gly, Gln, Tyr, Val, Lys, 0.758, 0.728, 6.8%, 0.707 , 0.706; Asn, Gly, Gln, Val, Lys, Leu, 0.758, 0.677, 0.2%, 0.640, 0.596; Asn, His, Cit, Tyr, Ile, Trp, 0.758, 0.730, 3.9%, 0.744, 0.734; , His, Tyr, Ile, Phe, Trp, Asn, His, Tyr, Lys, Ile, Phe, 0.758, 0.718, 4.4%, 0.710, 0.675; Asn, Thr, Cit, Lys, Ile, Leu, 0.758, 0.682, 1.5%, 0.671, 0.675; Gln, Ala, Tyr, Lys, Ile, Trp, 0.758, 0.724, 7.7%, 0.714, 0.746; Gln, Arg, Tyr, Val, Ile, Phe, 0.758, 0.735, 3.5%, 0.744 , 0.710; Gln, Cit, Ile, Leu, Phe, Trp, 0.758, 0.695, 0.2%, 0.703, 0.655; Gln, Cit, Tyr, Orn, Leu, Phe, 0.758, 0.712, 1.8%, 0.719, 0.684; , His, Ala, Cit, Met, Ile, 0.758, 0.709, 0.9%, 0.732, 0.732; Gln, His, Ala, Ile, Leu, Phe, 0.758, 0.696, 0.2%, 0.710, 0.669; , Val, Ile, Phe, 0.758, 0.700, 0.4%, 0.717, 0.686; Gln, His, Arg, Met, Ile, Phe, 0.758, 0.708, 0.0%, 0.736, 0.696; Gln, His, Cit, Tyr, Met , Ile, 0.758, 0.741, 3.3%, 0.762, 0.763; Gln, His, Orn, Lys, Ile, Phe, 0.758, 0.693, 0.6%, 0.687, 0.657; Gln, His, Thr, Cit, Arg, Ile, 0.758 , 0.710, 0.7%, 0.734, 0.746; Gln, His, Thr, Cit, Ile, Trp, 0.758, 0.710, 0.9%, 0.731, 0.732; Gln, His, Thr, Pro, Tyr, Ile, 0.758, 0.735, 3.1 %, 0.754, 0.769; Thr, Arg, Val, Lys, Ile, 0.758, 0.682, 1.1%, 0.687, 0.738; Gly, Gln, Ala, Tyr, Val, Ile, 0.758, 0.730, 6.6%, 0.725, 0.728; Gly, Gln, His, Ala, Met, Ile, 0.758, 0.703, 0.9%, 0.716, 0.706; Gly, Gln, His, Thr, Tyr, Ile, 0.758, 0.733, 4.4%, 0.751, 0.759; Gly, Gln, His, Tyr, Lys, Ile, 0.758, 0.723, 3.9%, 0.725, 0.753; Gly, Gln, His, Tyr, Orn, Leu, 0.758, 0.722, 2.4%, 0.720, 0.730; Gly, Gln, Thr, Tyr, Ile, Trp, 0.758, 0.727, 7.9%, 0.727, 0.730; Gly, Gln, Thr, Tyr, Leu, Trp, 0.758, 0.727, 7.2%, 0.708, 0.688; His, Ala, Arg, Tyr, Lys, Ile, 0.758, 0.711, 2.8% His, Ala, Tyr, Ile, Phe, Trp, 0.758, 0.708, 4.8%, 0.702, 0.673; His, Arg, Pro, Tyr, Lys, Ile, 0.758, 0.710, 3.7%, 0.709, 0.746 His, Arg, Tyr, Val, Lys, Ile, 0.758, 0.713, 2.9%, 0.712, 0.742; His, Cit, Arg, Tyr, Lys, Ile, 0.758, 0.713, 2.6%, 0.716, 0.751; His, Cit , Tyr, Ile, Leu, Phe, 0.758, 0.714, 2.0%, 0.718, 0.692; Ser, Asn, Cit, Arg, Lys, Ile, 0.758, 0.659, 2.6%, 0.645, 0.679; , Cit, Ile, 0.758, 0.696, 0 Ser, Asn, Gln, His, Lys, Ile, 0.758, 0.682, 2.0%, 0.673, 0.686; Ser, Asn, Gln, His, Tyr, Leu, 0.758, 0.733, 1.1%, Ser, Asn, Gly, Gln, Lys, Leu, 0.758, 0.672, 0.2%, 0.637, 0.604; Ser, Gln, Arg, Met, Lys, Ile, 0.758, 0.669, 0.2%, 0.660, 0.722; Ser, Gln, Cit, Tyr, Ile, Phe, 0.758, 0.718, 3.3%, 0.735, 0.730; Ser, Gln, His, Tyr, Leu, Trp, 0.758, 0.731, 3.5%, 0.725, 0.716; Tyr, Ile, Leu, Trp, 0.758, 0.717, 6.2%, 0.709, 0.726; Ser, Gln, Tyr, Met, Leu, Phe, 0.758, 0.733, 1.8%, 0.733, 0.675; Ser, His, Tyr, Met, Ile, Trp, 0.758, 0.722, 5.7%, 0.720, 0.702; Thr, Arg, Tyr, Ile, Leu, Phe, 0.758, 0.726, 2.9%, 0.730, 0.686; Tyr, Met, Lys, Ile, Leu, Phe, Tyr, Val, Met, Lys, Ile, Phe, 0.758, 0.720, 6.6%, 0.703, 0.688; Arg, Tyr, Met, Ile, Leu, Phe, 0.757, 0.725, 2.9%, 0.724, 0.675; Asn, Arg, Tyr, Lys, Leu, Trp, 0.757, 0.722, 4.0%, 0.709, 0.692; Asn, Gln, Cit, Ile, Leu, Phe, 0.757, 0.698, 0.0%, 0.706 , 0.645; Asn, Gln, His, Cit, T yr, Leu, 0.757, 0.734, 1.3%, 0.744, 0.734; Asn, Gln, His, Met, Orn, Ile, 0.757, 0.699, 1.8%, 0.722, 0.698; Asn, Gln, His, Val, Ile, Trp, 0.757, 0.708, 1.5%, 0.733, 0.712; Asn, Gln, Thr, Tyr, Ile, Leu, 0.757, 0.731, 4.2%, 0.733, 0.704; Asn,G

ly, Arg, Tyr, Leu, Phe, 0.757, 0.720, 1.8%, 0.708, 0.635; Asn, Gly, Cit, Met, Lys, Ile, 0.757, 0.678, 1.7%, 0.662, 0.671; Cit, Orn, Ile, 0.757, 0.681, 1.8%, 0.682, 0.667; Asn, Gly, Gln, His, Met, Ile, 0.757, 0.704, 1.3%, 0.725, 0.692; Asn, Gly, Gln, Thr, Lys, Ile, 0.757, 0.676, 1.8%, 0.649, 0.661; Asn, Gly, Gln, Tyr, Orn, Leu, 0.757, 0.725, 3.7%, 0.715, 0.673; Asn, Gly, Thr, Tyr, Leu, Phe, 0.757, 0.723, 4.0%, 0.708, 0.629; Asn, Thr, Arg, Lys, Ile, Trp, 0.757, 0.675, 2.2%, 0.670, 0.686; Cit, Pro, Tyr, Lys, Ile, Trp, 0.757, 0.713, 5.7% , 0.702, 0.742; Gln, Ala, Tyr, Orn, Ile, Phe, 0.757, 0.729, 5.0%, 0.739, 0.706; Gln, Arg, Tyr, Ile, Phe, Trp, 0.757, 0.729, 4.8%, 0.741, 0.716 Gln, Arg, Tyr, Lys, Leu, Trp, 0.757, 0.730, 3.3%, 0.720, 0.736; Gln, Cit, Pro, Tyr, Ile, Phe, 0.757, 0.728, 3.9%, 0.747, 0.726; Gln, His , Ala, Pro, Ile, Phe, 0.757, 0.699, 0.4%, 0.715, 0.680; Gln, His, Arg, Met, Lys, Ile, 0.757, 0.696, 0.6%, 0.702, 0.704; Gln, His, Val, Met , Orn, Ile, 0.757, 0.697, 0. 9%, 0.717, 0.700; Gln, Thr, Cit, Tyr, Ile, Phe, 0.757, 0.730, 3.5%, 0.750, 0.730; Gln, Tyr, Orn, Lys, Leu, Phe, 0.757, 0.721, 2.2%, 0.716 , 0.696; Gly, Gln, Ala, Arg, Lys, Ile, 0.757, 0.679, 0.7%, 0.674, 0.706; Gly, Gln, Arg, Tyr, Ile, Leu, 0.757, 0.724, 3.3%, 0.725, 0.718; , Gln, Cit, Pro, Tyr, Ile, 0.757, 0.720, 3.5%, 0.725, 0.734; Gly, Gln, His, Ala, Ile, Phe, 0.757, 0.697, 0.2%, 0.713, 0.677; , Thr, Cit, Ile, 0.757, 0.703, 1.3%, 0.717, 0.724; Gly, Gln, Orn, Lys, Ile, Phe, 0.757, 0.674, 0.7%, 0.645, 0.655; His, Cit, Tyr, Orn, Ile Ser, Asn, Gly, Gln, Tyr, Ile, 0.757, 0.716, 5.7%, 0.717, 0.726; Ser, Gln, His, Orn, Ile, Phe, 0.757 Ser, Gly, Gln, Thr, Tyr, Ile, 0.757, 0.713, 7.2%, 0.717, 0.738; Ser, His, Cit, Tyr, Ile, Phe, 0.757, 0.717, 2.2 %, 0.723, 0.710; Thr, Cit, Tyr, Lys, Ile, Phe, 0.757, 0.719, 4.8%, 0.719, 0.716; Ala, Arg, Tyr, Lys, Ile, Trp, 0.757, 0.714, 7.4%, 0.702, 0.726; Arg, Tyr, Lys, Leu, Ph e, Trp, 0.757, 0.722, 2.4%, 0.705, 0.659; Asn, Arg, Lys, Ile, Leu, Trp, 0.757, 0.675, 2.0%, 0.669, 0.680; Asn, Arg, Pro, Lys, Ile, Phe, Asn, Gln, His, Ala, Lys, Ile, 0.757, 0.695, 2.4%, 0.691, 0.690; Asn, Gln, His, Arg, Ile, Trp, 0.757, 0.710, 1.3%, 0.733, 0.712; Asn, Gln, His, Ile, Leu, Trp, 0.757, 0.709, 1.5%, 0.730, 0.706; Asn, Gly, Gln, His, Pro, Ile, 0.757, 0.703, 1.3%, 0.725 , 0.700; Asn, Gly, Gln, Met, Lys, Ile, 0.757, 0.677, 2.4%, 0.650, 0.669; Asn, Gly, Pro, Tyr, Ile, Leu, 0.757, 0.722, 5.3%, 0.706, 0.667; , His, Cit, Lys, Ile, Trp, 0.757, 0.692, 3.7%, 0.687, 0.667; Asn, His, Thr, Tyr, Leu, Phe, 0.757, 0.733, 2.6%, 0.735, 0.655; , Leu, Phe, Trp, 0.757, 0.721, 1.8%, 0.699, 0.643; Asn, Tyr, Val, Lys, Leu, Phe, 0.757, 0.720, 1.8%, 0.700, 0.647; , Trp, 0.757, 0.683, 1.1%, 0.681, 0.740; Gln, Arg, Val, Met, Lys, Ile, 0.757, 0.684, 1.3%, 0.688, 0.738; Gln, Cit, Pro, Tyr, Leu, Phe, 0.757 , 0.726, 1.8%, 0.732, 0.690 Gln, His, Arg, Tyr, Leu, Phe, 0.757, 0.734, 1.3%, 0.744, 0.714; Gln, His, Pro, Ile, Phe, Trp, 0.757, 0.704, 0.4%, 0.724, 0.677; Gln, His , Tyr, Orn, Leu, Trp, 0.757, 0.726, 3.5%, 0.722, 0.712; Gln, His, Tyr, Val, Leu, Phe, 0.757, 0.734, 1.5%, 0.741, 0.708; Gln, His, Tyr, Val , Lys, Ile, 0.757, 0.725, 3.9%, 0.735, 0.775; Gln, His, Tyr, Val, Met, Orn, 0.757, 0.729, 2.8%, 0.728, 0.720; Gln, His, Tyr, Val, Orn, Phe , 0.757, 0.729, 2.2%, 0.731, 0.704; Gln, His, Val, Met, Ile, Leu, 0.757, 0.711, 0.7%, 0.730, 0.720; Gln, Thr, Arg, Orn, Lys, Ile, 0.757, 0.682 , 0.7%, 0.680, 0.712; Gln, Thr, Tyr, Met, Lys, Ile, 0.757, 0.725, 5.7%, 0.720, 0.750; Gln, Tyr, Val, Lys, Ile, Trp, 0.757, 0.720, 7.2%, 0.713, 0.751; Gln, Tyr, Val, Orn, Leu, Phe, 0.757, 0.720, 2.0%, 0.721, 0.677; Gly, Gln, Arg, Val, Lys, Ile, 0.757, 0.676, 1.3%, 0.668, 0.716; Gly, Gln, His, Cit, Ile, Trp, 0.757, 0.708, 1.5%, 0.718, 0.700; Gly, Gln, His, Lys, Ile, Phe, 0.757, 0.694, 0.4%, 0.687, 0.659; His, Tyr, Val, Met, 0.757, 0 Ser, Asn, Arg, Met, Lys, Ile, 0.757, 0.659, 2.6%, 0.648, 0.684; Ser, Asn, Gln, His, Thr, Ile, 0.757, 0.694, 0.4 %, 0.714, 0.720; Ser, Asn, Gln, Tyr, Leu, Trp, 0.757, 0.726, 4.2%, 0.718, 0.700; Ser, Asn, Gly, Gln, His, Ile, 0.757, 0.693, 0.7%, 0.713, Ser, Asn, Gly, Gln, Tyr, Leu, 0.757, 0.729, 3.7%, 0.719, 0.677; Ser, Gly, Gln, His, Ile, Phe, 0.757, 0.692, 0.4%, 0.709, 0.682; Ser, Ala, Arg, Pro, Tyr, Met, Lys, Ile, Phe, 0.757, 0.716, 7.5%, 0.697, 0.682; Tyr, Lys, Ile, 0.757, 0.710, 4.8%, 0.706, 0.742; Arg, Orn, Lys, Ile, Leu, Phe, 0.757, 0.668, 0.9%, 0.654, 0.651; Arg, Pro, Tyr, Ile, Leu, Phe, 0.757, 0.719, 2.6%, 0.721, 0.679; Arg, Pro, Tyr, Lys, Ile, Trp, 0.757, 0.714, 7.4%, 0.702, 0.726; Arg, Tyr, Orn, Ile, Leu, Phe, 0.757, 0.718, 2.9%, 0.722, 0.684; Asn, Ala, Cit, Pro, Lys, Ile, 0.757, 0.677, 2.0%, 0.665, 0.692; Asn, Arg, Val, Lys, Ile, Leu, 0.757, 0.671, 2.2% , 0.664, 0.684; Lys, Ile, Trp, 0.757, 0.675, 2.0%, 0.670, 0.692; Asn, Cit, Arg, Val, Lys, Ile, 0.757, 0.672, 2.4%, 0.666, 0.688; Asn, Cit, Tyr, Lys, Leu, Phe, 0.757, 0.722, 2.0%, 0.705, 0.653; Asn, Cit, Tyr, Met, Ile, Phe, 0.757, 0.729, 5.1%, 0.733, 0.684; Asn, Gln, Cit, Tyr, Ile, Leu, 0.757, 0.731, 2.8%, 0.742, 0.720; Asn, Gln, Cit, Tyr, Orn, Ile, 0.757, 0.714, 4.8%, 0.729, 0.744; Asn, Gln, His, Arg, Tyr, Val, 0.757, 0.741, 2.2% , 0.745, 0.748; Asn, Gln, His, Met, Lys, Ile, 0.757, 0.698, 2.4%, 0.692, 0.682; Asn, Gln, His, Tyr, Met, Leu, 0.757, 0.739, 2.6%, 0.741, 0.710 Asn, Gln, Thr, Tyr, Lys, Ile, 0.757, 0.725, 8.1%, 0.719, 0.718; Asn, Gln, Val, Ile, Leu, Phe, 0.757, 0.693, 0.0%, 0.698, 0.631; Asn, Gly , Gln, Ala, Tyr, Leu, 0.757, 0.725, 3.7%, 0.714, 0.673; Asn, Gly, Gln, Arg, Tyr, Ile, 0.757, 0.725, 5.5%, 0.726, 0.716; , Leu, Trp, 0.757, 0.676, 0.2%, 0.643, 0.602; Asn, Gly, Gln, Thr, Tyr, Ile, 0.757, 0.724, 7.5%, 0.724, 0.714; Asn, Gly, Gln, Thr, Tyr, Leu , 0.757, 0.729, 5.5%, 0.71 7, 0.677; Asn, Gly, Gln, Tyr, Met, Ile, 0.757, 0.726, 6.6%, 0.720, 0.706; Asn, Gly, Gln, Tyr, Orn, Ile, 0.757, 0.730, 7.0%, 0.727, 0.718; Asn, His, Orn, Lys, Ile, Phe, 0.757, 0.687, 1.7%, 0.667, 0.625; Asn, His, Thr, Tyr, Ile, Phe, 0.757, 0.729, 3.1%, 0.738, 0.663; Tyr, Met, Ile, Trp, 0.757, 0.734, 5.3%, 0.739, 0.710; Asn, His, Tyr, Orn, Ile, Phe, 0.757, 0.728, 2.6%, 0.735, 0.675; Asn, Pro, Tyr, Met, Lys, Ile, 0.757, 0.715, 8.1%, 0.693, 0.692; Asn, Thr, Cit, Orn, Lys, Ile, 0.757, 0.671, 1.8%, 0.659, 0.663; Asn, Tyr, Lys, Ile, Leu, Phe, Asn, Tyr, Met, Ile, Leu, Phe, 0.757, 0.729, 3.7%, 0.718, 0.665; Asn, Tyr, Orn, Ile, Leu, Phe, 0.757, 0.729, 2.2%, 0.720, 0.663; Cit, Tyr, Met, Lys, Ile, Trp, 0.757, 0.715, 4.4%, 0.704, 0.712; Cit, Tyr, Orn, Lys, Ile, Trp, 0.757, 0.704, 5.3%, 0.695 , 0.732; Gln, Ala, Tyr, Val, Ile, Phe, 0.757, 0.728, 5.5%, 0.733, 0.702; Gln, Cit, Arg, Lys, Ile, Leu, 0.757, 0.686, 1.3%, 0.687, 0.738; , Cit, Pro, Orn, Ile, Phe, Gln, Cit, Tyr, Lys, Leu, Phe, 0.757, 0.725, 1.7%, 0.722, 0.710; Gln, His, Ala, Arg, Met, Ile, 0.757, 0.709, 0.6%, 0.733, 0.718; Gln, His, Ala, Met, Ile, Phe, 0.757, 0.699, 0.4%, 0.715, 0.682; Gln, His, Ala, Tyr, Lys, Leu, 0.757, 0.721, 2.2%, 0.717 , 0.742; Gln, His, Arg, Pro, Val, Ile, 0.757, 0.708, 0.9%, 0.735, 0.732; Gln, His, Cit, Arg, Ile, Trp, 0.757, 0.713, 0.9%, 0.728, 0.714; , His, Thr, Ala, Ile, Phe, 0.757, 0.697, 0.4%, 0.713, 0.690; Gln, His, Thr, Cit, Met, Ile, 0.757, 0.710, 0.4%, 0.731, 0.744; Gln, His, Thr , Tyr, Leu, Phe, 0.757, 0.737, 1.7%, 0.744, 0.704; Gln, His, Tyr, Lys, Ile, Leu, 0.757, 0.722, 3.3%, 0.728, 0.769; Gln, His, Tyr, Met, Leu , Trp, 0.757, 0.738, 3.5%, 0.733, 0.710; Gln, Thr, Tyr, Met, Leu, Phe, 0.757, 0.732, 1.7%, 0.733, 0.675; Gln, Tyr, Val, Ile, Leu, Trp, 0.757 Gln, Tyr, Val, Met, Leu, Phe, 0.757, 0.731, 1.7%, 0.731, 0.673; Gly, Arg, Tyr, Ile, Leu, Phe, 0.757, 0.712, 2.8 %, 0.709, 0.659; Gly, C it, Tyr, Lys, Ile, Trp, 0.757, 0.709, 5.3%, 0.690, 0.728; Gly, Gln, Arg, Tyr, Val, Ile, 0.757, 0.728, 5.9%, 0.724, 0.718; Tyr, Leu, Trp, 0.757, 0.727, 4.2%, 0.710, 0.696; Gly, Gln, His, Tyr, Val, Phe, 0.757, 0.732, 3.5%, 0.728, 0.694; Gly, Gln, His, Val, Ile, Phe, 0.757, 0.700, 0.2%, 0.723, 0.680; Gly, Gln, Lys, Ile, Leu, Phe, 0.757, 0.679, 0.6%, 0.651, 0.647; Gly, Gln, Thr, Arg, Lys, Ile, 0.757, Gly, Gln, Thr, Cit, Tyr, Ile, 0.757, 0.721, 4.2%, 0.725, 0.738; His, Cit, Pro, Tyr, Ile, Phe, 0.757, 0.713, 2.6% His, Cit, Tyr, Lys, Ile, Phe, 0.757, 0.711, 2.9%, 0.709, 0.726; His, Pro, Tyr, Ile, Phe, Trp, 0.757, 0.714, 4.4%, 0.709, 0.677 Ser, Arg, Tyr, Ile, Leu, Phe, 0.757, 0.719, 2.8%, 0.723, 0.688; Ser, Asn, Ala, Arg, Lys, Ile, 0.757, 0.655, 3.5%, 0.648, 0.696; Ser, Asn , Gln, His, Ala, Ile, 0.757, 0.691, 0.9%, 0.709, 0.716; Ser, Asn, His, Arg, Lys, Ile, 0.757, 0.667, 1.5%, 0.661, 0.673; , Leu, Phe, 0.757, 0.731, 2. 4%, 0.720, 0.645; Ser, Gln, His, Ile, Phe, Trp, 0.757, 0.686, 0.7%, 0.703, 0.677; Ser, Gln, His, Tyr, Lys, Ile, 0.757, 0.719, 3.3%, 0.724 , 0.771; Ser, Gln, Thr, Tyr, Leu, Phe, 0.757, 0.731, 1.7%, 0.733, 0.680; Ser, His, Tyr, Met, Ile, Phe, 0.757, 0.726, 2.6%, 0.724, 0.673; , Arg, Tyr, Orn, Lys, Ile, 0.756, 0.708, 4.2%, 0.708, 0.740; Ala, Cit, Arg, Tyr, Lys, Ile, 0.756, 0.712, 2.6%, 0.714, 0.746; , Ile, Leu, Phe, 0.756, 0.720, 2.8%, 0.722, 0.679; Asn, Arg, Met, Orn, Lys, Ile, 0.756, 0.664, 2.8%, 0.657, 0.673; Asn, Cit, Arg, Lys, Ile , Leu, 0.756, 0.677, 1.8%, 0.672, 0.684; Asn, Cit, Orn, Lys, Ile, Leu, 0.756, 0.673, 1.3%, 0.657, 0.649; Asn, Cit, Pro, Val, Lys, Ile, 0.756 , 0.679, 2.0%, 0.665, 0.688; Asn, Cit, Val, Orn, Lys, Ile, 0.756, 0.671, 2.0%, 0.660, 0.665; Asn, Gln, Ala, Tyr, Lys, Ile, 0.756, 0.721, 7.2 %, 0.713, 0.716; Asn, Gln, Arg, Tyr, Lys, Leu, 0.756, 0.729, 2.8%, 0.721, 0.714; Asn, Gln, His, Ala, Tyr, Leu, 0.756, 0.730, 1.1%, 0.735, 0.732; Asn, Gln, His, Cit, Ly s, Ile, 0.756, 0.700, 2.2%, 0.701, 0.700; Asn, Gln, His, Pro, Tyr, Leu, 0.756, 0.731, 1.1%, 0.739, 0.730; Asn, Gln, His, Thr, Ile, Leu, 0.756, 0.710, 1.7%, 0.735, 0.724; Asn, Gln, Met, Lys, Leu, Phe, 0.756, 0.682, 0.2%, 0.656, 0.623; Asn, Gl

y, Ala, Cit, Tyr, Ile, 0.756, 0.722, 6.8%, 0.719, 0.698; Asn, Gly, Arg, Val, Lys, Ile, 0.756, 0.669, 3.1%, 0.656, 0.675; Lys, Ile, Phe, 0.756, 0.681, 1.7%, 0.659, 0.661; Asn, Gly, Cit, Orn, Lys, Ile, 0.756, 0.672, 2.0%, 0.656, 0.661; Asn, Gly, Cit, Tyr, Ile, Phe, 0.756, 0.714, 5.5%, 0.715, 0.690; Asn, Gly, Gln, His, Ile, Trp, 0.756, 0.703, 1.3%, 0.723, 0.696; Asn, Gly, Gln, Val, Lys, Ile, 0.756, 0.668, 2.0%, 0.642, 0.673; Asn, Gly, Tyr, Met, Ile, Leu, 0.756, 0.724, 7.0%, 0.705, 0.657; Asn, His, Ala, Arg, Tyr, Ile, 0.756, 0.728, 3.7% , 0.741, 0.718; Asn, His, Cit, Tyr, Orn, Leu, 0.756, 0.708, 2.6%, 0.710, 0.679; Asn, His, Lys, Ile, Phe, Trp, 0.756, 0.687, 1.5%, 0.670, 0.629 Asn, His, Tyr, Val, Met, Ile, 0.756, 0.735, 4.4%, 0.738, 0.708; Asn, Thr, Cit, Arg, Lys, Ile, 0.756, 0.674, 2.0%, 0.671, 0.690; Asn, Thr , Tyr, Met, Leu, Phe, 0.756, 0.732, 2.9%, 0.726, 0.661; Asn, Thr, Tyr, Met, Lys, Ile, 0.756, 0.716, 9.4%, 0.700, 0.702; , Leu, Phe, 0.756, 0.731, 3.3 %, 0.727, 0.661; Cit, Arg, Pro, Tyr, Orn, Lys, 0.756, 0.681, 7.0%, 0.678, 0.771; Cit, Arg, Tyr, Lys, Ile, Leu, 0.756, 0.712, 2.4%, 0.710, 0.734; Cit, Tyr, Lys, Ile, Phe, Trp, 0.756, 0.712, 4.6%, 0.703, 0.712; Gln, Ala, Arg, Orn, Lys, Ile, 0.756, 0.678, 1.3%, 0.677, 0.712; Arg, Tyr, Val, Lys, Ile, 0.756, 0.720, 4.6%, 0.732, 0.787; Gln, Cit, Arg, Val, Lys, Ile, 0.756, 0.682, 1.3%, 0.685, 0.748; Ile, Phe, Trp, 0.756, 0.732, 4.4%, 0.747, 0.734; Gln, His, Ala, Tyr, Val, Trp, 0.756, 0.735, 4.6%, 0.728, 0.734; Gln, His, Lys, Ile, Phe, Trp, 0.756, 0.698, 0.6%, 0.697, 0.665; Gln, His, Met, Orn, Ile, Phe, 0.756, 0.691, 0.4%, 0.710, 0.677; Gln, His, Met, Orn, Lys, Ile, 0.756, 0.691, 0.9%, 0.684, 0.692; Gln, His, Thr, Lys, Ile, Phe, 0.756, 0.698, 0.6%, 0.695, 0.671; Gln, His, Thr, Orn, Ile, Phe, 0.756, 0.692, 0.4% , 0.711, 0.682; Gln, Orn, Lys, Ile, Leu, Phe, 0.756, 0.683, 0.6%, 0.659, 0.651; Gln, Thr, Arg, Tyr, Lys, Ile, 0.756, 0.725, 5.5%, 0.733, 0.773 ; Gln, Thr, Pro, Tyr, Leu , Phe, 0.756, 0.731, 2.9%, 0.735, 0.686; Gln, Thr, Tyr, Val, Leu, Phe, 0.756, 0.731, 1.7%, 0.733, 0.680; Gln, Tyr, Val, Met, Ile, Leu, 0.756 , 0.731, 3.5%, 0.735, 0.716; Gly, Gln, Ala, Tyr, Met, Ile, 0.756, 0.729, 6.4%, 0.726, 0.718; Gly, Gln, Arg, Met, Lys, Ile, 0.756, 0.678, 0.9 %, 0.668, 0.696; Gly, Gln, Arg, Pro, Tyr, Ile, 0.756, 0.725, 5.7%, 0.730, 0.734; Gly, Gln, Cit, Val, Lys, Ile, 0.756, 0.677, 1.3%, 0.661, 0.716; Gly, Gln, His, Cit, Arg, Ile, 0.756, 0.704, 0.9%, 0.718, 0.714; Gly, Gln, His, Met, Ile, Phe, 0.756, 0.700, 0.2%, 0.723, 0.684; Gln, His, Pro, Tyr, Leu, 0.756, 0.722, 3.1%, 0.719, 0.726; Gly, Gln, Tyr, Orn, Ile, Trp, 0.756, 0.730, 6.1%, 0.728, 0.740; Orn, Lys, Ile, 0.756, 0.721, 4.6%, 0.707, 0.753; Gly, Gln, Tyr, Val, Met, Lys, 0.756, 0.730, 5.1%, 0.705, 0.704; His, Ala, Cit, Tyr, Met, Ile, 0.756, 0.727, 3.3%, 0.733, 0.734; His, Tyr, Met, Ile, Leu, Phe, 0.756, 0.723, 2.8%, 0.717, 0.673; His, Tyr, Val, Met, Ile, Phe, 0.756, 0.730, 3.5%, 0.726, 0.688; Ser, Asn, Gln, Val, Lys, Ile, 0.756, 0.655, 2.8%, 0.632, 0.690; Ser, Asn, Tyr, Lys, Leu, Phe, 0.756, 0.727, 2.0%, 0.705, 0.647; Ser, Gln, Arg, Lys, Ile, Leu, 0.756, 0.666, 0.2%, 0.655, 0.724; Ser, Gln, His, Arg, Lys, Ile, 0.756, 0.681, 0.2%, 0.680, 0.724; Ser, Gln, His, Cit, Ile, Trp, 0.756, 0.690, 1.3%, 0.702, 0.720; Ser, Gln, His, Cit, Pro, Ile, 0.756, 0.697, 1.7%, 0.716, 0.738; Ser, Gln, His, Tyr, Lys, Leu, Ser, Gln, Lys, Ile, Phe, Trp, 0.756, 0.665, 1.1%, 0.638, 0.675; Ser, Gln, Pro, Tyr, Leu, Phe, 0.756, 0.726, 2.2%, 0.725, 0.684; Ser, Gly, His, Tyr, Ile, Phe, 0.756, 0.716, 4.4%, 0.713, 0.677; Ser, His, Pro, Tyr, Ile, Phe, 0.756, 0.717, 3.7%, 0.713 Thr, Arg, Tyr, Orn, Lys, Ile, 0.756, 0.709, 7.5%, 0.711, 0.738; Thr, Tyr, Met, Lys, Ile, Phe, 0.756, 0.720, 5.7%, 0.706, 0.694; , Cit, Tyr, Lys, Ile, Trp, 0.756, 0.714, 5.7%, 0.702, 0.738; Asn, Ala, Arg, Orn, Lys, Ile, 0.756, 0.666, 3.3%, 0.662, 0.677; , Orn, Lys, Ile, 0.756, 0. 669, 2.2%, 0.657, 0.682; Asn, Ala, Cit, Tyr, Orn, Ile, 0.756, 0.715, 4.6%, 0.727, 0.726; Asn, Cit, Arg, Met, Lys, Ile, 0.756, 0.677, 1.8% , 0.672, 0.696; Asn, Cit, Orn, Lys, Ile, Phe, 0.756, 0.675, 1.8%, 0.657, 0.653; Asn, Cit, Pro, Tyr, Ile, Phe, 0.756, 0.726, 4.8%, 0.733, 0.684 Asn, Cit, Tyr, Orn, Ile, Trp, 0.756, 0.714, 6.1%, 0.724, 0.714; Asn, Gln, Ala, Tyr, Ile, Leu, 0.756, 0.725, 3.7%, 0.729, 0.702; Asn, Gln , Arg, Ile, Leu, Phe, 0.756, 0.697, 0.2%, 0.703, 0.639; Asn, Gln, Arg, Met, Lys, Ile, 0.756, 0.684, 2.4%, 0.679, 0.714; , Ile, Trp, 0.756, 0.684, 1.5%, 0.672, 0.690; Asn, Gln, Cit, Tyr, Lys, Leu, 0.756, 0.726, 2.2%, 0.718, 0.718; Asn, Gln, Cit, Tyr, Orn, Leu , 0.756, 0.714, 2.8%, 0.719, 0.706; Asn, Gln, His, Orn, Leu, Phe, 0.756, 0.691, 0.0%, 0.688, 0.600; Asn, Gln, His, Orn, Lys, Leu, 0.756, 0.686 , 1.5%, 0.667, 0.639; Asn, Gln, Ile, Leu, Phe, Trp, 0.756, 0.696, 0.2%, 0.704, 0.633; Asn, Gln, Lys, Ile, Leu, Trp, 0.756, 0.682, 1.1%, 0.660, 0.669; Asn, Gln, Thr, Val, Leu, Phe, 0.756, 0.683, 0.0%, 0.672, 0.613; Asn, Gln, Tyr, Val, Lys, Leu, 0.756, 0.725, 2.6%, 0.716, 0.712; Asn, Gly, Arg, Tyr, Ile, Leu, 0.756, 0.721, 5.5%, 0.711, 0.665; Asn, Gly, Cit, Lys, Ile, Trp, 0.756, 0.679, 1.5%, 0.660, 0.671; Asn, Gly, Gln, His, Lys, Leu, 0.756, 0.686, 0.4%, 0.661, 0.633; Asn, Gly, Gln, Orn, Leu, Phe, 0.756, 0.671, 0.2%, 0.652, 0.578; Asn, His, Arg, Tyr, Ile, Leu, 0.756, 0.726, 2.9% , 0.736, 0.704; Asn, His, Cit, Tyr, Ile, Phe, 0.756, 0.722, 2.4%, 0.741, 0.698; Asn, His, Pro, Tyr, Met, Ile, 0.756, 0.736, 3.7%, 0.742, 0.718 Asn, His, Thr, Tyr, Met, Ile, 0.756, 0.734, 4.4%, 0.743, 0.708; Asn, His, Val, Lys, Ile, Phe, 0.756, 0.683, 1.8%, 0.665, 0.625; Asn, Orn , Lys, Ile, Leu, Phe, 0.756, 0.680, 1.5%, 0.650, 0.627; Asn, Thr, Arg, Val, Lys, Ile, 0.756, 0.670, 2.9%, 0.663, 0.684; , Leu, Phe, 0.756, 0.681, 1.5%, 0.649, 0.621; Asn, Thr, Pro, Tyr, Leu, Phe, 0.756, 0.726, 3.7%, 0.723, 0.647; Asn, Thr, Tyr, Leu, Phe, Trp , 0.756, 0.728, 3.9%, 0.720 , 0.653; Asn, Tyr, Met, Lys, Ile, Phe, 0.756, 0.715, 7.5%, 0.691, 0.671; Asn, Tyr, Orn, Lys, Leu, Phe, 0.756, 0.721, 1.8%, 0.699, 0.643; , Ala, Arg, Lys, Ile, Trp, 0.756, 0.683, 1.7%, 0.682, 0.720; Gln, Ala, Tyr, Ile, Leu, Trp, 0.756, 0.732, 5.7%, 0.726, 0.724; Gln, Ala, Tyr , Met, Lys, Ile, 0.756, 0.724, 5.1%, 0.718, 0.744; Gln, Arg, Met, Lys, Ile, Phe, 0.756, 0.680, 0.7%, 0.678, 0.698; Gln, Cit, Arg, Tyr, Orn , Ile, 0.756, 0.711, 3.3%, 0.729, 0.746; Gln, Cit, Tyr, Lys, Leu, Trp, 0.756, 0.730, 3.5%, 0.711, 0.730; Gln, His, Cit, Tyr, Lys, Ile, 0.756 , 0.726, 2.9%, 0.740, 0.789; Gln, His, Met, Ile, Phe, Trp, 0.756, 0.706, 0.4%, 0.725, 0.692; Gln, His, Met, Lys, Ile, Phe, 0.756, 0.698, 0.6 %, 0.695, 0.671; Gln, His, Orn, Lys, Leu, Phe, 0.756, 0.685, 0.2%, 0.666, 0.635; Gln, His, Pro, Orn, Ile, Phe, 0.756, 0.693, 0.6%, 0.710, 0.680; Gln, His, Thr, Ile, Phe, Trp, 0.756, 0.702, 0.4%, 0.720, 0.682; Gln, His, Tyr, Lys, Ile, Trp, 0.756, 0.725, 5.9%, 0.723, 0.748; Thr, Cit, Arg, Lys, Ile, 0 Gln, Thr, Tyr, Ile, Leu, Trp, 0.756, 0.735, 5.9%, 0.731, 0.722; Gln, Tyr, Lys, Ile, Leu, Trp, 0.756, 0.723 , 6.8%, 0.711, 0.730; Gln, Tyr, Met, Lys, Leu, Phe, 0.756, 0.725, 2.0%, 0.715, 0.694; Gln, Tyr, Orn, Ile, Leu, Trp, 0.756, 0.732, 6.1%, 0.727, 0.728; Gly, Arg, Tyr, Lys, Ile, Trp, 0.756, 0.710, 6.6%, 0.690, 0.702; Gly, Gln, His, Ala, Ile, Trp, 0.756, 0.703, 1.7%, 0.715, 0.708; Gly, Gln, His, Cit, Ile, Leu, 0.756, 0.704, 0.9%, 0.719, 0.714; Gly, Gln, His, Cit, Met, Ile, 0.756, 0.703, 0.9%, 0.716, 0.708; Lys, Ile, Phe, Trp, 0.756, 0.671, 0.7%, 0.642, 0.653; Gly, Gln, Thr, Ala, Tyr, Ile, 0.756, 0.729, 7.0%, 0.732, 0.734; Gly, Gln, Thr, Tyr, Ile, Leu, 0.756, 0.720, 6.2%, 0.716, 0.706; Gly, His, Cit, Tyr, Met, Ile, 0.756, 0.724, 2.9%, 0.722, 0.720; His, Ala, Tyr, Met, Ile, Trp, His, Arg, Tyr, Val, Ile, Phe, 0.756, 0.723, 2.9%, 0.729, 0.690; His, Cit, Tyr, Lys, Ile, Trp, 0.756, 0.715, 3.5%, 0.707, 0.732; His, Ci t, Tyr, Met, Orn, Ile, 0.756, 0.712, 4.4%, 0.718, 0.712; Ser, Asn, Gln, His, Ile, Trp, 0.756, 0.692, 1.1%, 0.713, 0.718; Ser, Asn, Gln, His, Met, Ile, 0.756, 0.694, 0.2%, 0.714, 0.712; Ser, Asn, Gln, Lys, Ile, Trp, 0.756, 0.661, 2.6%, 0.636, 0.679; Ser, Asn, Gln, Tyr, Val, Ser, Asn, His, Cit, Lys, Ile, 0.756, 0.679, 2.6%, 0.669, 0.682; Ser, Asn, Thr, Tyr, Leu, Phe, 0.756, Ser, Gln, Cit, Tyr, Leu, Phe, 0.756, 0.734, 1.8%, 0.736, 0.690; Ser, Gln, His, Arg, Ile, Trp, 0.756, 0.689, 0.6% , 0.709, 0.716; Ser, Gln, His, Arg, Orn, Ile, 0.756, 0.684, 0.6%, 0.705, 0.716; Ser, Gln, His, Met, Lys, Ile, 0.756, 0.685, 0.6%, 0.677, 0.712 Ser, Gln, His, Tyr, Leu, Phe, 0.756, 0.740, 1.3%, 0.748, 0.708; Ser, Gln, His, Val, Ile, Phe, 0.756, 0.685, 0.4%, 0.706, 0.694; Ser, Gln , Tyr, Val, Lys, Ile, 0.756, 0.706, 4.2%, 0.699, 0.767; Ser, Gly, Gln, Cit, Tyr, Ile, 0.756, 0.715, 3.7%, 0.720, 0.740; , Ile, Phe, 0.756, 0.711, 3.5 %, 0.711, 0.680; Thr, Ala, Arg, Tyr, Lys, Ile, 0.756, 0.715, 7.5%, 0.716, 0.748; Ala, Arg, Tyr, Val, Lys, Ile, 0.755, 0.713, 3.5%, 0.709, Arg, Pro, Tyr, Val, Lys, Ile, 0.755, 0.709, 4.8%, 0.708, 0.738; Asn, Ala, Arg, Pro, Tyr, Lys, 0.755, 0.704, 6.4%, 0.689, 0.740; Asn, Cit, Met, Lys, Ile, Leu, 0.755, 0.681, 1.5%, 0.668, 0.677; Asn, Cit, Tyr, Met, Ile, Leu, 0.755, 0.730, 4.2%, 0.731, 0.690; Lys, Ile, Trp, 0.755, 0.680, 2.0%, 0.663, 0.686; Asn, Gln, Arg, Pro, Lys, Ile, 0.755, 0.675, 2.2%, 0.669, 0.675; Asn, Gln, His, Pro, Tyr, Val, 0.755, 0.737, 2.4%, 0.734, 0.730; Asn, Gln, His, Tyr, Leu, Trp, 0.755, 0.735, 3.7%, 0.731, 0.708; Asn, Gln, His, Tyr, Orn, Lys, 0.755, 0.723, 4.4%, 0.722, 0.753; Asn, Gln, His, Tyr, Val, Trp, 0.755, 0.742, 3.5%, 0.737, 0.732; Asn, Gln, Pro, Tyr, Ile, Leu, 0.755, 0.727, 3.5% , 0.730, 0.698; Asn, Gln, Tyr, Val, Ile, Phe, 0.755, 0.731, 6.8%, 0.735, 0.700; Asn, Gly, Arg, Tyr, Val, Lys, 0.755, 0.720, 5.0%, 0.705, 0.706 ; Asn, Gly, Cit, Tyr, Leu , Phe, 0.755, 0.715, 2.9%, 0.697, 0.621; Asn, Gly, Cit, Tyr, Orn, Leu, 0.755, 0.708, 2.8%, 0.697, 0.647; Asn, Gly, Gln, Cit, Lys, Leu, 0.755 , 0.675, 0.2%, 0.640, 0.598; Asn, Gly, Gln, His, Thr, Ile, 0.755, 0.703, 1.3%, 0.726, 0.704; Asn, Gly

, His, Pro, Tyr, Ile, 0.755, 0.724, 4.6%, 0.725, 0.702; Asn, Gly, Tyr, Lys, Leu, Trp, 0.755, 0.714, 3.7%, 0.684, 0.643; Asn, His, Ala, Tyr , Met, Ile, 0.755, 0.733, 4.2%, 0.740, 0.704; Asn, His, Arg, Tyr, Ile, Phe, 0.755, 0.721, 1.8%, 0.737, 0.679; Asn, His, Arg, Tyr, Ile, Trp , 0.755, 0.733, 5.9%, 0.745, 0.730; Asn, His, Thr, Cit, Lys, Ile, 0.755, 0.691, 3.5%, 0.684, 0.661; Asn, His, Tyr, Met, Orn, Ile, 0.755, 0.731 , 4.4%, 0.738, 0.706; Asn, Pro, Tyr, Met, Leu, Phe, 0.755, 0.722, 2.8%, 0.713, 0.641; Asn, Thr, Arg, Lys, Ile, Leu, 0.755, 0.674, 1.7%, Asn, Thr, Arg, Met, Lys, Ile, 0.755, 0.674, 1.8%, 0.670, 0.688; Asn, Tyr, Met, Leu, Phe, Trp, 0.755, 0.727, 2.9%, 0.711, 0.645; Asn, Tyr, Met, Lys, Leu, Phe, 0.755, 0.726, 2.2%, 0.705, 0.643; Gln, Ala, Cit, Tyr, Ile, Phe, 0.755, 0.727, 3.7%, 0.747, 0.726; Tyr, Leu, Phe, Trp, 0.755, 0.725, 2.6%, 0.720, 0.679; Gln, Arg, Met, Orn, Lys, Ile, 0.755, 0.680, 1.1%, 0.675, 0.708; Ile, Phe, 0.755, 0.729, 2.8% , 0.748, 0.722; Gln, Cit, Arg, Tyr, Leu, Phe, 0.755, 0.733, 1.7%, 0.738, 0.696; Gln, His, Ala, Arg, Val, Ile, 0.755, 0.706, 0.9%, 0.735, 0.732 Gln, His, Ala, Ile, Leu, Trp, 0.755, 0.708, 1.8%, 0.718, 0.708; Gln, His, Arg, Orn, Lys, Ile, 0.755, 0.689, 1.1%, 0.697, 0.702; Gln, His , Arg, Val, Orn, Ile, 0.755, 0.696, 0.9%, 0.721, 0.712; Gln, His, Cit, Val, Lys, Ile, 0.755, 0.699, 1.3%, 0.710, 0.750; Gln, His, Pro, Val , Ile, Phe, 0.755, 0.703, 0.4%, 0.725, 0.680; Gln, His, Thr, Met, Orn, Ile, 0.755, 0.699, 0.9%, 0.715, 0.704; Gln, His, Tyr, Orn, Lys, Ile , 0.755, 0.722, 3.1%, 0.729, 0.771; Gln, His, Tyr, Orn, Lys, Leu, 0.755, 0.719, 2.4%, 0.715, 0.742; Gln, His, Tyr, Val, Lys, Leu, 0.755, 0.724 , 3.1%, 0.718, 0.744; Gln, His, Tyr, Val, Lys, Trp, 0.755, 0.734, 6.6%, 0.721, 0.746; Gln, Pro, Tyr, Met, Lys, Ile, 0.755, 0.723, 5.0%, Gln, Pro, Tyr, Orn, Leu, Phe, 0.755, 0.722, 3.1%, 0.720, 0.682; Gln, Pro, Tyr, Val, Leu, Phe, 0.755, 0.726, 2.4%, 0.727, 0.682; Gln, Thr, Arg, Met, Lys, Ile, 0.755, 0.686, 1.1%, 0.685, 0.722; Gly, Arg, Tyr, Lys, Leu, Trp, 0.755, 0.713, 3.7%, 0.687, 0.671; Gly, Arg, Tyr, Met, Lys, Leu, 0.755, Gly, Gln, Ala, Arg, Tyr, Ile, 0.755, 0.727, 6.1%, 0.732, 0.734; Gly, Gln, Arg, Tyr, Val, Lys, 0.755, 0.725, 3.5% , 0.710, 0.714; Gly, Gln, Cit, Arg, Tyr, Ile, 0.755, 0.722, 3.5%, 0.727, 0.740; Gly, Gln, His, Pro, Met, Ile, 0.755, 0.702, 0.9%, 0.718, 0.704 Gly, Gln, Tyr, Met, Leu, Trp, 0.755, 0.727, 4.4%, 0.705, 0.677; Gly, Gln, Tyr, Orn, Ile, Leu, 0.755, 0.726, 4.0%, 0.720, 0.724; Gly, His , Thr, Tyr, Ile, Phe, 0.755, 0.720, 2.9%, 0.727, 0.675; His, Ala, Arg, Lys, Ile, Phe, 0.755, 0.679, 0.2%, 0.669, 0.675; , Leu, Phe, 0.755, 0.712, 3.1%, 0.705, 0.671; His, Arg, Tyr, Lys, Ile, Leu, 0.755, 0.712, 2.8%, 0.709, 0.736; His, Tyr, Lys, Ile, Leu, Phe Ser, Asn, Gln, Cit, Lys, Ile, 0.755, 0.668, 2.0%, 0.651, 0.688; Ser, Asn, Gln, Cit, Tyr, Ile, 0.755, 0.720 , 3.3%, 0.738, 0.753; Ser, Asn, Gln, His, Ile, Leu, 0.755, 0.694, 0.4%, 0.715, 0.720; Ser, Asn, Gln, His, Orn, Leu, 0.755, 0.693, 0.9%, 0.692, 0.637; His, Pro, Tyr, Ile, 0.755, 0.722, 4.0%, 0.729, 0.712; Ser, Gln, His, Ala, Cit, Ile, 0.755, 0.690, 0.9%, 0.708, 0.736; Ser, Gln, His, Cit, Ser, Gln, Pro, Tyr, Ile, Trp, 0.755, 0.714, 7.5%, 0.713, 0.759; Ser, Gly, Cit, Tyr, Val, Ile, Ser, Gly, Gln, Ala, Tyr, Ile, 0.755, 0.718, 5.9%, 0.720, 0.740; Ser, Gly, Gln, Tyr, Met, Ile, 0.755, 0.720, 5.3%, 0.714, 0.724; Thr, Tyr, Lys, Ile, Phe, Trp, 0.755, 0.717, 5.7%, 0.702, 0.688; Arg, Pro, Tyr, Lys, Ile, Leu, 0.754, 0.709, 4.2%, 0.703 , 0.734; Arg, Tyr, Val, Lys, Ile, Leu, 0.754, 0.710, 3.5%, 0.705, 0.736; Asn, Arg, Met, Lys, Ile, Leu, 0.754, 0.675, 1.7%, 0.669, 0.686; , Cit, Met, Orn, Lys, Ile, 0.754, 0.671, 2.0%, 0.658, 0.661; Asn, Cit, Pro, Lys, Ile, Trp, 0.754, 0.680, 1.8%, 0.664, 0.692; , Tyr, Orn, Ile, 0.754, 0.7 14, 4.4%, 0.727, 0.728; Asn, Gln, Cit, Lys, Ile, Leu, 0.754, 0.685, 1.3%, 0.673, 0.686; Asn, Gln, His, Thr, Orn, Leu, 0.754, 0.693, 0.9% , 0.694, 0.639; Asn, Gln, Orn, Ile, Leu, Phe, 0.754, 0.686, 0.2%, 0.685, 0.625; Asn, Gln, Thr, Lys, Ile, Leu, 0.754, 0.683, 1.5%, 0.662, 0.675 Asn, Gln, Thr, Lys, Ile, Phe, 0.754, 0.678, 1.1%, 0.656, 0.649; Asn, Gln, Thr, Orn, Leu, Phe, 0.754, 0.677, 0.0%, 0.664, 0.596; Asn, Gln , Thr, Val, Lys, Leu, 0.754, 0.681, 0.2%, 0.651, 0.625; Asn, Gln, Tyr, Lys, Ile, Trp, 0.754, 0.719, 7.4%, 0.708, 0.710; Asn, Gln, Tyr, Orn Asn, Gln, Tyr, Val, Ile, Trp, 0.754, 0.734, 7.7%, 0.729, 0.726; Asn, Gly, Arg, Tyr, Met, Ile , 0.754, 0.726, 5.5%, 0.722, 0.682; Asn, Gly, Arg, Tyr, Val, Ile, 0.754, 0.724, 5.9%, 0.716, 0.680; Asn, Gly, Cit, Tyr, Lys, Leu, 0.754, 0.710 , 2.4%, 0.689, 0.653; Asn, Gly, Gln, Pro, Tyr, Ile, 0.754, 0.723, 6.2%, 0.720, 0.710; Asn, Gly, His, Tyr, Ile, Phe, 0.754, 0.717, 3.5%, 0.720, 0.665; Asn, Gly, Thr, L ys, Ile, Leu, 0.754, 0.679, 1.5%, 0.649, 0.647; Asn, Gly, Thr, Tyr, Lys, Leu, 0.754, 0.715, 5.5%, 0.691, 0.649; Trp, 0.754, 0.717, 3.3%, 0.695, 0.627; Asn, His, Ala, Arg, Lys, Ile, 0.754, 0.682, 2.2%, 0.682, 0.684; Asn, His, Ala, Tyr, Ile, Leu, 0.754, 0.724, 5.3%, 0.722, 0.684; Asn, His, Ala, Tyr, Ile, Phe, 0.754, 0.722, 3.5%, 0.728, 0.669; Asn, His, Thr, Cit, Tyr, Ile, 0.754, 0.728, 4.2% , 0.747, 0.730; Asn, His, Tyr, Met, Leu, Phe, 0.754, 0.733, 1.7%, 0.724, 0.657; Asn, Thr, Met, Lys, Ile, Leu, 0.754, 0.680, 1.7%, 0.655, 0.659 Cit, Arg, Tyr, Val, Lys, Ile, 0.754, 0.712, 2.6%, 0.712, 0.736; Gln, Arg, Tyr, Orn, Leu, Phe, 0.754, 0.720, 1.7%, 0.727, 0.684; Gln, Arg , Val, Ile, Leu, Phe, 0.754, 0.695, 0.2%, 0.702, 0.635; Gln, Cit, Arg, Ile, Leu, Phe, 0.754, 0.695, 0.2%, 0.702, 0.651; , Leu, Trp, 0.754, 0.734, 3.7%, 0.738, 0.742; Gln, Cit, Tyr, Met, Ile, Phe, 0.754, 0.727, 3.9%, 0.748, 0.734; Gln, Cit, Tyr, Met, Orn, Ile , 0.754, 0.710, 3.7%, 0.728, 0.736; Gln, Cit, Tyr, Orn, Lys, Leu, 0.754, 0.710, 2.2%, 0.708, 0.742; Gln, Cit, Tyr, Val, Leu, Phe, 0.754, 0.729, 1.7%, 0.731, 0.686; His, Ala, Met, Orn, Ile, 0.754, 0.693, 1.1%, 0.714, 0.700; Gln, His, Arg, Tyr, Val, Orn, 0.754, 0.726, 1.5%, 0.737, 0.746; Tyr, Leu, Phe, 0.754, 0.732, 1.5%, 0.739, 0.712; Gln, His, Cit, Tyr, Val, Orn, 0.754, 0.715, 1.8%, 0.723, 0.746; Gln, His, Lys, Ile, Leu, Phe, 0.754, 0.696, 0.4%, 0.699, 0.688; Gln, His, Pro, Ile, Leu, Phe, 0.754, 0.702, 0.2%, 0.720, 0.671; Gln, His, Pro, Met, Ile, Phe, 0.754, 0.703, 0.4%, 0.724, 0.679; Gln, His, Pro, Tyr, Lys, Ile, 0.754, 0.723, 2.9%, 0.729, 0.771; Gln, His, Thr, Ala, Ile, Trp, 0.754, 0.705, 1.8% , 0.724, 0.718; Gln, His, Thr, Ile, Leu, Phe, 0.754, 0.700, 0.0%, 0.719, 0.688; Gln, His, Thr, Val, Met, Ile, 0.754, 0.710, 0.4%, 0.729, 0.736 Gln, Lys, Ile, Leu, Phe, Trp, 0.754, 0.684, 0.6%, 0.660, 0.653; Gln, Thr, Ala, Tyr, Ile, Leu, 0.754, 0.729, 4.6%, 0.735, 0.740; Gln, Thr , Lys, Ile, Leu, Phe, 0. Gln, Tyr, Met, Lys, Leu, Trp, 0.754, 0.732, 3.7%, 0.713, 0.714; Gly, Cit, Tyr, Ile, Leu, Trp, 0.754, 0.713, 4.0%, 0.697, 0.692; Gly, Gln, Ala, Cit, Tyr, Leu, 0.754, 0.718, 2.2%, 0.709, 0.706; Gly, Gln, Ala, Tyr, Lys, Leu, 0.754, 0.718, 3.5%, 0.698 , 0.716; Gly, Gln, Cit, Arg, Lys, Ile, 0.754, 0.679, 1.1%, 0.670, 0.702; Gly, Gln, Cit, Arg, Orn, Ile, 0.754, 0.678, 1.8%, 0.679, 0.671; , Gln, Cit, Lys, Ile, Phe, 0.754, 0.676, 0.9%, 0.653, 0.663; Gly, Gln, His, Arg, Lys, Ile, 0.754, 0.691, 0.6%, 0.692, 0.700; , Tyr, Orn, Ile, 0.754, 0.727, 3.1%, 0.743, 0.755; Gly, Gln, His, Val, Lys, Ile, 0.754, 0.690, 1.7%, 0.689, 0.728; Gly, Gln, Thr, Pro, Tyr , Ile, 0.754, 0.725, 5.7%, 0.728, 0.734; Gly, Gln, Tyr, Orn, Lys, Leu, 0.754, 0.719, 3.5%, 0.700, 0.718; Gly, Gln, Tyr, Val, Lys, Leu, 0.754 Gly, Thr, Cit, Tyr, Ile, Phe, 0.754, 0.715, 5.1%, 0.717, 0.692; His, Ala, Pro, Tyr, Ile, Phe, 0.754, 0.706, 3.5 %, 0.705, 0.696; His, Cit , Tyr, Met, Lys, Ile, 0.754, 0.722, 4.2%, 0.715, 0.732; His, Cit, Tyr, Orn, Ile, Trp, 0.754, 0.700, 3.9%, 0.705, 0.728; , Leu, Phe, 0.754, 0.711, 2.9%, 0.703, 0.663; His, Pro, Tyr, Lys, Ile, Phe, 0.754, 0.705, 3.7%, 0.693, 0.686; His, Pro, Tyr, Orn, Ile, Phe His, Thr, Pro, Tyr, Ile, Phe, 0.754, 0.723, 2.6%, 0.732, 0.679; His, Thr, Tyr, Met, Ile, Trp, 0.754, 0.728 His, Tyr, Met, Orn, Ile, Trp, 0.754, 0.728, 4.8%, 0.727, 0.698; His, Tyr, Val, Met, Ile, Trp, 0.754, 0.729, 9.2%, Ser, Asn, Cit, Tyr, Ile, Leu, 0.754, 0.719, 3.1%, 0.722, 0.714; Ser, Asn, Gln, Ala, Tyr, Ile, 0.754, 0.713, 4.8%, 0.721, 0.730; Ser, Asn, Gln, Lys, Ile, Phe, 0.754, 0.660, 1.8%, 0.636, 0.655; Ser, Asn, Gln, Thr, Lys, Ile, 0.754, 0.661, 2.6%, 0.637, 0.679; Ser, Asn, Gln, Tyr, Lys, Leu, 0.754, 0.725, 2.6%, 0.713, 0.712; Ser, Asn, His, Lys, Ile, Phe, 0.754, 0.674, 1.7%, 0.655, 0.633; Lys, Ile, 0.754, 0.709, 4.6% , 0.703, 0.761; Ser, Gln, Arg, Tyr, Ile, Trp, 0.754, 0.716, 5.1%, 0.723, 0.751; Ser, Gln, Cit, Tyr, Ile, Trp, 0.754, 0.717, 3.7%, 0.723, 0.763 Ser, Gln, His, Cit, Arg, Ile, 0.754, 0.693, 0.9%, 0.711, 0.736; Ser, Gln, His, Pro, Tyr, Ile, 0.754, 0.724, 2.6%, 0.745, 0.773; Ser, Gln , Pro, Tyr, Lys, Ile, 0.754, 0.707, 4.2%, 0.703, 0.757; Ser, Gln, Tyr, Orn, Leu, Phe, 0.754, 0.723, 2.4%, 0.723, 0.679; , Lys, Ile, 0.754, 0.717, 6.8%, 0.718, 0.750; Thr, Cit, Tyr, Lys, Ile, Trp, 0.754, 0.717, 7.5%, 0.710, 0.742; Arg, Met, Lys, Ile, Phe, Trp , 0.754, 0.674, 0.7%, 0.662, 0.677; Arg, Met, Orn, Lys, Ile, Phe, 0.754, 0.669, 0.7%, 0.658, 0.667; Arg, Orn, Lys, Ile, Phe, Trp, 0.754, 0.668 , 0.7%, 0.657, 0.663; Arg, Tyr, Met, Lys, Leu, Phe, 0.754, 0.723, 2.4%, 0.712, 0.661; Arg, Tyr, Val, Orn, Lys, Trp, 0.754, 0.718, 5.7%, Arg, Val, Met, Lys, Ile, Phe, 0.754, 0.674, 0.7%, 0.663, 0.675; Asn, Gln, Ala, Lys, Ile, Leu, 0.754, 0.681, 2.0%, 0.665, 0.671; Asn, Gln, Arg, Tyr, Ile, Phe, 0.754, 0.729, 5.0%, 0.743, 0.700; Asn, Gln, His, Ala, Orn, Leu, 0.754, 0.685, 0.6%, 0.685, 0.639; Asn, Gln, His, Orn, Leu, Trp, 0.754, 0.694, 0.9%, 0.694, 0.637; Asn, Gln, His, Thr, Ile, Trp, 0.754, 0.705, 1.8%, 0.728, 0.710; Asn, Gln,

His, Tyr, Val, Lys, 0.754, 0.734, 4.4%, 0.724, 0.734; Asn, Gln, Tyr, Val, Lys, Ile, 0.754, 0.717, 6.4%, 0.706, 0.718; Asn, Gln, Val, Orn, Lys, Ile, 0.754, 0.672, 2.0%, 0.650, 0.684; Asn, Gln, Val, Orn, Lys, Leu, 0.754, 0.671, 0.2%, 0.643, 0.607; Asn, Gly, Ala, Cit, Lys, Ile, Asn, Gly, Gln, Ala, Tyr, Val, 0.754, 0.734, 7.9%, 0.713, 0.694; Asn, Gly, His, Tyr, Val, Ile, 0.754, 0.720, 5.3%, 0.715, 0.682; Asn, Gly, Tyr, Met, Leu, Phe, 0.754, 0.720, 3.1%, 0.698, 0.619; Asn, His, Arg, Ile, Leu, Phe, 0.754, 0.692, 0.0%, 0.691 , 0.623; Asn, His, Arg, Pro, Ile, Phe, 0.754, 0.690, 0.2%, 0.700, 0.635; Asn, His, Pro, Tyr, Ile, Phe, 0.754, 0.725, 2.6%, 0.733, 0.680; , His, Pro, Tyr, Val, Ile, 0.754, 0.728, 5.5%, 0.735, 0.710; Asn, His, Tyr, Lys, Ile, Trp, 0.754, 0.714, 6.1%, 0.704, 0.686; Asn, His, Tyr Asn, His, Tyr, Orn, Lys, Ile, 0.754, 0.717, 6.1%, 0.708, 0.710; Asn, Thr, Cit, Val, Lys , Ile, 0.754, 0.681, 1.8%, 0.669, 0.682; Gln, Ala, Cit, Tyr, Orn, Ile, 0.754, 0.711, 3.5%, 0.729, 0.746; Gln, Ala, Tyr, Met, Ile, Leu, 0.754, 0.729, 3.5%, 0.733, 0.718; Gln, Arg, Ile, Leu, Phe, Trp, 0.754, 0.697, 0.2%, 0.701, 0.639; Gln, Arg, Met, Lys, Ile, Leu, 0.754, 0.686, 1.3%, 0.686, 0.734; Tyr, Lys, Ile, Leu, 0.754, 0.722, 4.0%, 0.729, 0.773; Gln, Arg, Tyr, Met, Ile, Leu, 0.754, 0.733, 2.9%, 0.737, 0.724; Gln, Arg, Tyr, Orn, Leu, Trp, 0.754, 0.721, 3.1%, 0.719, 0.704; Gln, Arg, Tyr, Orn, Lys, Leu, 0.754, 0.712, 1.7%, 0.711, 0.730; Gln, Cit, Arg, Tyr, Lys, Ile, Gln, Cit, Tyr, Met, Leu, Phe, 0.754, 0.731, 1.8%, 0.731, 0.688; Gln, Cit, Val, Ile, Leu, Phe, 0.754, 0.694, 0.2%, 0.703, 0.651; Gln, His, Ala, Arg, Pro, Ile, 0.754, 0.707, 0.9%, 0.735, 0.726; Gln, His, Arg, Lys, Ile, Trp, 0.754, 0.698, 1.3%, 0.701 , 0.710; Gln, His, Arg, Orn, Ile, Leu, 0.754, 0.697, 0.9%, 0.721, 0.710; Gln, His, Arg, Orn, Ile, Trp, 0.754, 0.695, 1.5%, 0.714, 0.690; , His, Arg, Pro, Met, I le, 0.754, 0.709, 1.1%, 0.734, 0.714; Gln, His, Cit, Tyr, Lys, Leu, 0.754, 0.723, 1.8%, 0.724, 0.748; Gln, His, Cit, Tyr, Orn, Leu, 0.754, Gln, His, Pro, Val, Met, Ile, 0.754, 0.708, 1.1%, 0.730, 0.726; Gln, His, Thr, Met, Ile, Phe, 0.754, 0.700, 0.4% , 0.721, 0.690; Gln, His, Thr, Pro, Met, Ile, 0.754, 0.709, 1.1%, 0.727, 0.726; Gln, His, Tyr, Val, Lys, Phe, 0.754, 0.739, 1.8%, 0.731, 0.712 Gln, His, Val, Met, Ile, Trp, 0.754, 0.709, 0.9%, 0.725, 0.706; Gln, Thr, Arg, Tyr, Ile, Leu, 0.754, 0.732, 3.1%, 0.740, 0.742; Gln, Thr , Cit, Tyr, Leu, Phe, 0.754, 0.731, 1.7%, 0.734, 0.686; Gln, Tyr, Met, Orn, Ile, Leu, 0.754, 0.727, 3.9%, 0.728, 0.706; Gln, Tyr, Met, Orn , Lys, Ile, 0.754, 0.726, 4.8%, 0.719, 0.748; Gln, Tyr, Val, Lys, Leu, Trp, 0.754, 0.727, 4.4%, 0.704, 0.728; , 0.754, 0.712, 4.6%, 0.707, 0.686; Gly, Gln, Ala, Pro, Tyr, Ile, 0.754, 0.728, 5.0%, 0.731, 0.744; Gly, Gln, Arg, Tyr, Leu, Trp, 0.754, 0.727 , 3.9%, 0.713, 0.688; y, Gln, Arg, Tyr, Met, Ile, 0.754, 0.725, 6.4%, 0.725, 0.724; Gly, Gln, Cit, Orn, Ile, Phe, 0.754, 0.680, 1.5%, 0.683, 0.657; His, Ala, Lys, Ile, 0.754, 0.693, 1.3%, 0.686, 0.708; Gly, Gln, His, Cit, Val, Ile, 0.754, 0.704, 0.9%, 0.720, 0.724; Gly, Gln, His, Lys, Ile, Trp, 0.754, 0.699, 2.0%, 0.686, 0.692; Gly, Gln, His, Tyr, Val, Ile, 0.754, 0.725, 3.1%, 0.741, 0.753; Gly, Gln, Thr, Arg, Tyr, Leu, Gly, Gln, Thr, Lys, Leu, Phe, 0.754, 0.675, 0.2%, 0.642, 0.613; Gly, Gln, Thr, Tyr, Lys, Leu, 0.754, 0.720, 5.9%, 0.705, 0.716; Gly, Gln, Thr, Tyr, Met, Ile, 0.754, 0.727, 6.1%, 0.723, 0.720; Gly, Gln, Val, Lys, Ile, Phe, 0.754, 0.669, 1.3%, 0.640 , 0.661; Gly, His, Ala, Tyr, Ile, Phe, 0.754, 0.706, 3.3%, 0.703, 0.686; Gly, His, Tyr, Ile, Leu, Phe, 0.754, 0.710, 3.3%, 0.700, 0.657; , Tyr, Met, Ile, Leu, Phe, 0.754, 0.717, 4.8%, 0.700, 0.643; His, Arg, Tyr, Lys, Ile, Trp, 0.754, 0.716, 5.9%, 0.705, 0.722; , Met, Ile, Trp, 0.754, 0.734 His, Thr, Tyr, Met, Orn, Ile, 0.754, 0.725, 6.1%, 0.730, 0.702; His, Thr, Tyr, Orn, Ile, Phe, 0.754, 0.724, 2.9%, Ser, Asn, Gln, His, Pro, Ile, 0.754, 0.692, 0.7%, 0.710, 0.716; Ser, Asn, Gln, Lys, Ile, Leu, 0.754, 0.664, 2.6%, 0.638, 0.671; Ser, Asn, Gln, Orn, Lys, Ile, 0.754, 0.663, 2.6%, 0.638, 0.680; Ser, Asn, Gln, Orn, Lys, Leu, 0.754, 0.666, 0.2%, 0.637, 0.609; His, Tyr, Ile, Leu, 0.754, 0.720, 5.3%, 0.720, 0.692; Ser, Asn, His, Tyr, Ile, Phe, 0.754, 0.721, 3.3%, 0.728, 0.673; Ser, Gln, Ala, Tyr, Ile, Trp, 0.754, 0.716, 7.0%, 0.714, 0.753; Ser, Gln, Cit, Tyr, Ile, Leu, 0.754, 0.717, 3.1%, 0.728, 0.751; Ser, Gln, His, Ala, Tyr, Leu, Ser, Gln, His, Arg, Val, Ile, 0.754, 0.690, 0.6%, 0.710, 0.746; Ser, Gln, His, Cit, Ile, Leu, 0.754, 0.692, 1.1%, 0.711, 0.740; Ser, Gln, His, Cit, Met, Ile, 0.754, 0.692, 1.1%, 0.709, 0.734; Ser, Gln, Tyr, Orn, Lys, Ile, 0.754, 0.715, 4.2%, 0.708 , 0.769; Ser, Gly, Gln, His Ser, Gly, Gln, His, Tyr, Leu, 0.754, 0.729, 2.4%, 0.726, 0.718; Ser, Thr, Tyr, Lys, Ile, Phe , 0.754, 0.709, 5.3%, 0.695, 0.690; Thr, Tyr, Lys, Ile, Leu, Phe, 0.754, 0.720, 4.0%, 0.713, 0.684; Tyr, Orn, Lys, Ile, Leu, Phe, 0.754, 0.719 , 3.7%, 0.701, 0.679; Ala, Arg, Lys, Ile, Leu, Phe, 0.753, 0.672, 0.2%, 0.667, 0.677; Arg, Val, Orn, Lys, Ile, Phe, 0.753, 0.667, 0.7%, Asn, Arg, Met, Lys, Ile, Trp, 0.753, 0.673, 1.8%, 0.667, 0.684; Asn, Arg, Val, Lys, Ile, Trp, 0.753, 0.670, 2.8%, 0.662, 0.684; Asn, Cit, Pro, Lys, Ile, Leu, 0.753, 0.681, 1.7%, 0.665, 0.673; Asn, Cit, Tyr, Ile, Leu, Trp, 0.753, 0.727, 5.1%, 0.725, 0.696; Tyr, Lys, Leu, Trp, 0.753, 0.719, 2.4%, 0.696, 0.675; Asn, Gln, Ala, Orn, Lys, Ile, 0.753, 0.678, 2.2%, 0.661, 0.684; Asn, Gln, Ala, Tyr, Leu, Phe, 0.753, 0.722, 1.8%, 0.727, 0.680; Asn, Gln, Ala, Tyr, Leu, Trp, 0.753, 0.728, 4.6%, 0.718, 0.702; Asn, Gln, Ala, Val, Lys, Ile, 0.753, 0.673, 2.4%, 0.658, 0 .692; Asn, Gln, Cit, Tyr, Leu, Trp, 0.753, 0.734, 2.9%, 0.728, 0.708; Asn, Gln, His, Ala, Tyr, Val, 0.753, 0.736, 2.4%, 0.733, 0.730; , Gln, His, Met, Orn, Leu, 0.753, 0.692, 0.9%, 0.692, 0.637; Asn, Gln, His, Pro, Tyr, Lys, 0.753, 0.729, 4.8%, 0.726, 0.750; Asn, Gln, Met, Lys, Ile; , Val, Orn, Leu, 0.753, 0.692, 0.9%, 0.692, 0.635; , Phe, 0.753, 0.676, 0.6%, 0.655, 0.657; Asn, Gln, Met, Lys, Ile, Trp, 0.753, 0.680, 2.0%, 0.659, 0.682; Asn, Gln, Orn, Lys, Ile, Trp, 0.753 , 0.676, 2.2%, 0.654, 0.677; Asn, Gln, Pro, Tyr, Lys, Leu, 0.753, 0.722, 2.6%, 0.710, 0.698; Asn, Gln, Thr, Orn, Lys, Ile, 0.753, 0.675, 1.7 %, 0.651, 0.680; Asn, Gln, Thr, Tyr, Leu, Trp, 0.753, 0.736, 5.3%, 0.724, 0.702; Asn, Gln, Thr, Val, Lys, Ile, 0.753, 0.673, 1.8%, 0.653, 0.690; Asn, Gln, Tyr, Orn, Lys, Ile, 0.753, 0.726, 6.2%, 0.716, 0.716; Asn, Gly, Ala, Arg, Lys, Ile, 0.753, 0.669, 3.9%, 0.656, 0.673; Gly, Arg, Pro, Lys, Ile, 0.75 3, 0.668, 2.8%, 0.651, 0.657; Asn, Gly, Cit, Tyr, Leu, Trp, 0.753, 0.717, 4.0%, 0.693, 0.643; Asn, Gly, Cit, Tyr, Val, Leu, 0.753, 0.720, 3.1%, 0.705, 0.661; Asn, Gly, Gln, Tyr, Met, Leu, 0.753, 0.724, 3.1%, 0.713, 0.663; Asn, Gly, His, Arg, Lys, Ile, 0.753, 0.679, 1.7%, 0.675 , 0.665; Asn, Gly, His, Tyr, Ile, Leu, 0.753, 0.717, 4.6%, 0.711, 0.675; Asn, Gly, Pro, Tyr, Lys, Leu, 0.753, 0.712, 3.1%, 0.685, 0.653; , His, Arg, Ile, Phe, Trp, 0.753, 0.692, 0.0%, 0.699, 0.635; Asn, His, Cit, Arg, Lys, Ile, 0.753, 0.685, 1.7%, 0.689, 0.680; , Met, Lys, Ile, 0.753, 0.685, 3.7%, 0.663, 0.627; Asn, His, Pro, Tyr, Ile, Trp, 0.753, 0.726, 6.2%, 0.732, 0.714; Asn, His, Tyr, Val, Ile , Leu, 0.753, 0.723, 5.3%, 0.722, 0.682; Asn, Tyr, Ile, Leu, Phe, Trp, 0.753, 0.724, 3.7%, 0.712, 0.649; Asn, Tyr, Met, Orn, Lys, Ile, 0.753 , 0.723, 8.1%, 0.702, 0.696; Asn, Tyr, Val, Met, Leu, Phe, 0.753, 0.728, 2.4%, 0.718, 0.643; Asn, Val, Lys, Ile, Leu, Phe, 0.753, 0.678, 1.3 %, 0.652, 0.625; Pro, Tyr, Lys, Ile, 0.753, 0.708, 3.1%, 0.711, 0.746; Gln, Ala, Arg, Met, Lys, Ile, 0.753, 0.685, 1.1%, 0.687, 0.724; Gln, Ala, Arg, Tyr, Lys, Ile, 0.753, 0.722, 4.0%, 0.729, 0.773; Gln, Arg, Tyr, Leu, Phe, Trp, 0.753, 0.734, 2.4%, 0.732, 0.684; Gln, Arg, Tyr, Met, Leu, Phe, Gln, Cit, Lys, Ile, Leu, Phe, 0.753, 0.686, 0.6%, 0.671, 0.669; Gln, Cit, Orn, Lys, Ile, Trp, 0.753, 0.675, 2.2%, 0.663, 0.704; Gln, Cit, Pro, Orn, Ile, Trp, 0.753, 0.682, 1.8%, 0.688, 0.679; Gln, Cit, Tyr, Val, Orn, Ile, 0.753, 0.713, 3.9%, 0.725 , 0.740; Gln, His, Ala, Arg, Ile, Leu, 0.753, 0.706, 0.9%, 0.731, 0.720; Gln, His, Ala, Pro, Val, Ile, 0.753, 0.707, 1.1%, 0.728, 0.734; , His, Arg, Lys, Ile, Leu, 0.753, 0.697, 1.1%, 0.710, 0.742; Gln, His, Arg, Met, Ile, Trp, 0.753, 0.711, 1.1%, 0.730, 0.702; Gln, His, Arg , Pro, Ile, Leu, 0.753, 0.708, 1.1%, 0.733, 0.720; Gln, His, Met, Ile, Leu, Trp, 0.753, 0.708, 1.1%, 0.723, 0.704; Gln, His, Pro, Met, Ile , Leu, 0.753, 0.709, 1.1%, Gln, His, Pro, Tyr, Lys, Leu, 0.753, 0.721, 3.5%, 0.719, 0.748; Gln, His, Thr, Arg, Orn, Ile, 0.753, 0.695, 0.9%, 0.718, 0.710; Gln, His, Thr, Val, Ile, Phe, 0.753, 0.700, 0.4%, 0.722, 0.694; Gln, His, Tyr, Val, Orn, Leu, 0.753, 0.723, 1.5%, 0.725, 0.742; Tyr, Lys, Ile, Trp, 0.753, 0.724, 7.0%, 0.712, 0.750; Gln, Pro, Tyr, Lys, Leu, Trp, 0.753, 0.725, 5.5%, 0.707, 0.728; Gln, Thr, Cit, Tyr, Orn, Ile, 0.753, 0.710, 3.3%, 0.729, 0.742; Gln, Thr, Lys, Ile, Leu, Trp, 0.753, 0.686, 0.7%, 0.658, 0.696; Gln, Val, Orn, Lys, Ile, Phe, Gly, Ala, Arg, Lys, Ile, Phe, 0.753, 0.666, 0.6%, 0.660, 0.665; Gly, Arg, Orn, Lys, Ile, Phe, 0.753, 0.667, 0.9%, 0.655, 0.653; Gly, Cit, Tyr, Met, Orn, Ile, 0.753, 0.710, 7.2%, 0.705, 0.708; Gly, Cit, Tyr, Val, Ile, Trp, 0.753, 0.721, 6.4%, 0.704 , 0.716; Gly, Gln, Ala, Cit, Lys, Ile, 0.753, 0.678, 0.7%, 0.664, 0.716; Gly, Gln, Cit, Lys, Ile, Trp, 0.753, 0.679, 0.7%, 0.660, 0.702; , Gln, His, Ala, Cit, I le, 0.753, 0.702, 1.3%, 0.720, 0.712; Gly, Gln, His, Arg, Tyr, Val, 0.753, 0.733, 1.8%, 0.731, 0.734; Gly, Gln, His, Lys, Ile, Leu, 0.753, 0.694, 1.7%, 0.689, 0.728; Gly, Gln, His, Met, Orn, Ile, 0.753, 0.693, 0.7%, 0.709, 0.688; Gly, Gln,

His, Orn, Lys, Ile, 0.753, 0.692, 1.5%, 0.685, 0.700; Gly, Gln, His, Thr, Ile, Phe, 0.753, 0.696, 0.2%, 0.715, 0.680; Gly, Gln, His, Tyr, Val, Lys, 0.753, 0.727, 4.6%, 0.717, 0.750; Gly, Gln, Orn, Lys, Ile, Trp, 0.753, 0.676, 0.7%, 0.645, 0.688; Gly, Gln, Pro, Tyr, Lys, Leu, Gly, Gln, Thr, Tyr, Val, Ile, 0.753, 0.727, 7.9%, 0.721, 0.716; Gly, Gln, Tyr, Val, Lys, Phe, 0.753, 0.728, His, Thr, Tyr, Ile, Leu, Phe, 0.753, 0.723, 3.3%, 0.725, 0.669; His, Thr, Tyr, Met, Lys, Ile, 0.753, 0.722, 7.4%, 0.710 , 0.708; Ser, Asn, Arg, Tyr, Lys, Leu, 0.753, 0.719, 3.3%, 0.710, 0.690; Ser, Asn, Gln, His, Lys, Leu, 0.753, 0.687, 0.2%, 0.667, 0.657; Ser, Asn, Thr, Tyr, Lys, Ile, 0.753, 0.700, 9.4%, 0.682, 0.696; Ser, Asn, Tyr , Ile, Leu, Phe, 0.753, 0.722, 3.1%, 0.714, 0.663; Ser, Cit, Tyr, Lys, Ile, Trp, 0.753, 0.706, 6.2%, 0.690, 0.744; , Phe, 0.753, 0.671, 0.4%, Ser, Gln, His, Ile, Leu, Phe, 0.753, 0.690, 0.4%, 0.704, 0.679; Ser, Gln, His, Thr, Arg, Ile, 0.753, 0.693, 0.6%, 0.709, 0.744; Ser, Gln, Pro, Tyr, Leu, Trp, 0.753, 0.723, 5.1%, 0.711, 0.710; Ser, Gln, Tyr, Met, Ile, Trp, 0.753, 0.717, 7.4%, 0.716, 0.744; Val, Lys, Ile, Trp, 0.753, 0.660, 1.5%, 0.632, 0.712; Ser, Gly, Gln, Lys, Ile, Phe, 0.753, 0.662, 1.3%, 0.633, 0.657; Orn, Ile, 0.753, 0.720, 5.3%, 0.719, 0.742; Ser, Gly, Gln, Val, Lys, Ile, 0.753, 0.657, 1.7%, 0.632, 0.708; Ser, His, Arg, Lys, Ile, Phe, Ser, His, Cit, Tyr, Met, Ile, 0.753, 0.721, 3.5%, 0.724, 0.730; Thr, Tyr, Orn, Ile, Leu, Phe, 0.753, 0.724, 3.3%, 0.719, 0.675; Asn, Ala, Cit, Val, Lys, Ile, 0.752, 0.678, 1.7%, 0.667, 0.692; Asn, Arg, Tyr, Ile, Leu, Phe, 0.752, 0.723, 2.4%, 0.720 , 0.659; Asn, Arg, Tyr, Orn, Leu, Phe, 0.752, 0.714, 1.7%, 0.713, 0.649; Asn, Arg, Val, Met, Lys, Ile, 0.752, 0.670, 2.4%, 0.661, 0.686; , Cit, Arg, Pro, Lys, I le, 0.752, 0.674, 2.4%, 0.664, 0.677; Asn, Cit, Arg, Tyr, Ile, Phe, 0.752, 0.728, 3.7%, 0.738, 0.692; Asn, Cit, Tyr, Met, Leu, Phe, 0.752, 0.728, 1.7%, 0.721, 0.651; Asn, Cit, Tyr, Met, Orn, Ile, 0.752, 0.715, 6.1%, 0.722, 0.714; Asn, Cit, Tyr, Orn, Lys, Leu, 0.752, 0.704, 2.8% , 0.694, 0.671; Asn, Gln, Arg, Lys, Leu, Phe, 0.752, 0.674, 0.0%, 0.645, 0.609; Asn, Gln, Arg, Tyr, Leu, Trp, 0.752, 0.731, 4.4%, 0.724, 0.700 Asn, Gln, Cit, Tyr, Met, Leu, 0.752, 0.733, 3.1%, 0.735, 0.716; Asn, Gln, His, Ala, Lys, Leu, 0.752, 0.686, 2.4%, 0.675, 0.649; Asn, Gln , His, Ala, Orn, Lys, 0.752, 0.674, 1.5%, 0.671, 0.702; Asn, Gln, His, Pro, Lys, Ile, 0.752, 0.693, 2.4%, 0.685, 0.673; Asn, Gln, His, Tyr , Lys, Phe, 0.752, 0.737, 3.3%, 0.740, 0.759; Asn, Gln, Met, Lys, Ile, Leu, 0.752, 0.682, 1.7%, 0.660, 0.673; Asn, Gln, Orn, Lys, Ile, Leu , 0.752, 0.677, 2.0%, 0.653, 0.663; Asn, Gln, Thr, Cit, Tyr, Leu, 0.752, 0.733, 2.8%, 0.735, 0.710; Asn, Gln, Thr, Tyr, Lys, Leu, 0.752, 0.727 , 3.5%, 0.714, 0.704; n, Gln, Tyr, Met, Orn, Leu, 0.752, 0.723, 4.0%, 0.718, 0.684; Asn, Gln, Tyr, Val, Leu, Trp, 0.752, 0.732, 5.1%, 0.720, 0.698; Ala, Tyr, Lys, Leu, 0.752, 0.712, 2.6%, 0.685, 0.653; Asn, Gly, Arg, Pro, Tyr, Ile, 0.752, 0.724, 5.7%, 0.723, 0.696; Asn, Gly, Gln, Arg, Orn, Leu, 0.752, 0.676, 0.2%, 0.662, 0.596; Asn, Gly, Gln, Pro, Lys, Ile, 0.752, 0.672, 2.4%, 0.645, 0.649; Asn, Gly, His, Met, Ile, Phe, Asn, Gly, His, Tyr, Lys, Leu, 0.752, 0.712, 3.5%, 0.686, 0.653; Asn, His, Ala, Pro, Tyr, Ile, 0.752, 0.725, 3.9%, 0.732, 0.706; Asn, His, Arg, Pro, Tyr, Lys, 0.752, 0.711, 4.8%, 0.705, 0.757; Asn, His, Cit, Val, Orn, Lys, 0.752, 0.682, 0.2%, 0.669 , 0.633; Asn, His, Met, Orn, Lys, Ile, 0.752, 0.683, 3.9%, 0.662, 0.627; Asn, His, Pro, Lys, Ile, Phe, 0.752, 0.682, 2.2%, 0.663, 0.621; , His, Thr, Arg, Ile, Phe, 0.752, 0.692, 0.2%, 0.695, 0.629; Asn, His, Thr, Met, Ile, Phe, 0.752, 0.691, 0.7%, 0.692, 0.609; , Orn, Ile, Phe, 0.752, 0.684 , 0.7%, 0.690, 0.611; Asn, His, Tyr, Val, Ile, Trp, 0.752, 0.728, 6.8%, 0.724, 0.690; Asn, Pro, Tyr, Ile, Leu, Phe, 0.752, 0.723, 3.3%, Asn, Thr, Cit, Tyr, Ile, Phe, 0.752, 0.728, 4.2%, 0.736, 0.690; Asn, Thr, Cit, Tyr, Val, Ile, 0.752, 0.732, 5.3%, 0.739, 0.710; Asn, Thr, Tyr, Met, Lys, Leu, 0.752, 0.719, 3.9%, 0.698, 0.671; Asn, Tyr, Val, Ile, Leu, Phe, 0.752, 0.721, 2.6%, 0.716, 0.651; Tyr, Orn, Leu, Trp, 0.752, 0.701, 5.0%, 0.693, 0.665; Cit, Tyr, Met, Ile, Leu, Phe, 0.752, 0.719, 3.1%, 0.715, 0.671; Gln, Ala, Arg, Lys, Ile, Leu, 0.752, 0.684, 1.1%, 0.685, 0.724; Gln, Ala, Arg, Val, Lys, Ile, 0.752, 0.680, 0.9%, 0.685, 0.740; Gln, Arg, Tyr, Met, Ile, Phe, Gln, Cit, Arg, Met, Lys, Ile, 0.752, 0.687, 1.1%, 0.688, 0.734; Gln, Cit, Tyr, Met, Lys, Ile, 0.752, 0.722, 3.7%, 0.725, 0.763; Gln, Cit, Tyr, Val, Ile, Phe, 0.752, 0.730, 3.1%, 0.742, 0.712; Gln, His, Arg, Met, Orn, Ile, 0.752, 0.696, 0.9%, 0.717 , 0.698; Gln, His, Arg, Tyr , Orn, Lys, 0.752, 0.713, 1.1%, 0.731, 0.785; Gln, His, Arg, Val, Ile, Leu, 0.752, 0.709, 0.6%, 0.733, 0.720; Gln, His, Met, Orn, Leu, Phe , 0.752, 0.687, 0.0%, 0.678, 0.629; Gln, His, Pro, Met, Ile, Trp, 0.752, 0.710, 1.3%, 0.726, 0.708; Gln, His, Thr, Ala, Arg, Ile, 0.752, 0.706 , 0.7%, 0.734, 0.730; Gln, His, Thr, Arg, Ile, Trp, 0.752, 0.702, 1.3%, 0.726, 0.722; Gln, His, Thr, Arg, Met, Ile, 0.752, 0.708, 0.4%, Gln, His, Thr, Met, Ile, Leu, 0.752, 0.709, 0.4%, 0.727, 0.722; Gln, His, Thr, Pro, Ile, Leu, 0.752, 0.709, 1.3%, 0.727, 0.728; Gln, His, Thr, Pro, Ile, Phe, 0.752, 0.700, 0.4%, 0.718, 0.682; Gln, His, Tyr, Val, Met, Leu, 0.752, 0.735, 2.0%, 0.734, 0.716; Tyr, Orn, Leu, Trp, 0.752, 0.721, 4.2%, 0.710, 0.708; Gln, Thr, Arg, Tyr, Leu, Phe, 0.752, 0.733, 1.8%, 0.739, 0.690; Gln, Thr, Pro, Tyr, Ile, Leu, 0.752, 0.730, 4.6%, 0.733, 0.736; Gln, Tyr, Met, Orn, Leu, Trp, 0.752, 0.723, 4.8%, 0.714, 0.706; Gln, Tyr, Val, Orn, Leu, Trp, 0.752, 0.721, 5.1%, 0.707, 0 .708; Gln, Val, Lys, Ile, Phe, Trp, 0.752, 0.674, 0.7%, 0.653, 0.671; Gly, Ala, Cit, Tyr, Val, Ile, 0.752, 0.717, 5.3%, 0.704, 0.720; , Arg, Lys, Ile, Leu, Phe, 0.752, 0.672, 0.7%, 0.652, 0.643; Gly, Gln, Ala, Cit, Orn, Ile, 0.752, 0.677, 1.5%, 0.679, 0.675; Gly, Gln, Arg , Tyr, Ile, Trp, 0.752, 0.726, 7.4%, 0.730, 0.736; Gly, Gln, Cit, Val, Orn, Ile, 0.752, 0.679, 2.4%, 0.677, 0.659; , Phe, 0.752, 0.689, 0.0%, 0.667, 0.639; Gly, Gln, His, Pro, Ile, Phe, 0.752, 0.696, 0.2%, 0.714, 0.671; Gly, Gln, His, Thr, Tyr, Leu, 0.752 , 0.726, 2.8%, 0.724, 0.722; Gly, Gln, Orn, Lys, Leu, Phe, 0.752, 0.669, 0.2%, 0.634, 0.602; Gly, Gln, Thr, Cit, Tyr, Leu, 0.752, 0.718, 3.7 %, 0.711, 0.692; Gly, Gln, Thr, Lys, Ile, Trp, 0.752, 0.677, 0.7%, 0.645, 0.688; Gly, Gln, Thr, Tyr, Val, Leu, 0.752, 0.723, 6.8%, 0.713, 0.700; Gly, Gln, Tyr, Met, Orn, Ile, 0.752, 0.733, 6.2%, 0.727, 0.722; Gly, His, Thr, Tyr, Met, Ile, 0.752, 0.725, 5.3%, 0.722, 0.698; His, Tyr, Ile, Phe, Trp, 0.75 2, 0.707, 4.2%, 0.700, 0.667; Gly, His, Tyr, Lys, Ile, Phe, 0.752, 0.703, 4.0%, 0.690, 0.680; Gly, His, Tyr, Met, Orn, Ile, 0.752, 0.726, His, Cit, Tyr, Met, Ile, Trp, 0.752, 0.726, 4.0%, 0.732, 0.728; His, Tyr, Lys, Ile, Phe, Trp, 0.752, 0.704, 4.4%, 0.685 Ser, Ala, Arg, Lys, Ile, Phe, 0.752, 0.654, 1.3%, 0.647, 0.682; Ser, Asn, Cit, Pro, Tyr, Ile, 0.752, 0.722, 4.6%, 0.728, 0.722; , Asn, Cit, Tyr, Leu, Phe, 0.752, 0.728, 1.5%, 0.721, 0.645; Ser, Asn, Gln, Arg, Tyr, Ile, 0.752, 0.716, 5.0%, 0.727, 0.740; Ser, Asn, His, Tyr, Ile, Trp, 0.752, 0.715, 4.2%, 0.717, 0.700; Ser, Gln, Cit, Lys, Ile , Phe, 0.752, 0.666, 1.3%, 0.647, 0.682; Ser, Gln, His, Tyr, Met, Leu, 0.752, 0.736, 2.0%, 0.737, 0.724; Ser, Gln, His, Tyr, Val, Trp, 0.752 Ser, Gln, Thr, Lys, Ile, Trp, 0.752, 0.663, 1.7%, 0.635, 0.698; Ser, Gln, Tyr, Lys, Leu, Phe, 0.752, 0.727, 2.0 %, 0.723, 0.694; Ser, Gln, Val, Lys, Ile, Phe, 0.752, 0.653, 1.5%, 0.631, 0.679; Ser, Gly, Gln, Arg, Tyr, Ile, 0.752, 0.715, 5.3%, 0.723, 0.738; Lys, Leu, 0.752, 0.724, 3.9%, 0.707, 0.720; Ser, His, Tyr, Ile, Phe, Trp, 0.752, 0.710, 4.2%, 0.705, 0.671; Ser, Thr, Arg, Lys, Ile, Phe, 0.752, 0.657, 1.3%, 0.639, 0.661; Thr, Arg, Orn, Lys, Ile, Phe, 0.752, 0.669, 0.9%, 0.659, 0.661; Thr, Pro, Tyr, Ile, Leu, Phe, 0.752, 0.723, 3.7%, 0.718, 0.663; Ala, Arg, Lys, Ile, Phe, Trp, 0.752, 0.666, 0.7%, 0.659, 0.671; Ala, Arg, Met, Lys, Ile, Phe, 0.752, 0.669, 0.6%, 0.663 , 0.677; Ala, Arg, Tyr, Lys, Ile, Leu, 0.752, 0.708, 3.1%, 0.703, 0.736; Ala, Arg, Val, Lys, Ile, Phe, 0.752, 0.666, 0.7%, 0.661, 0.675; Asn, Ala, Arg, Val, Lys, Ile, 0.752, 0.667, 3.5%, 0.662, 0.688; Asn, Ala, Cit , Tyr, Met, Ile, 0.752, 0.733, 5.1%, 0.736, 0.704; Asn, Arg, Pro, Orn, Lys, Ile, 0.752, 0.664, 3.3%, 0.657, 0.659; Asn, Arg, Pro, Tyr, Lys , Leu, 0.752, 0.711, 3.9%, Asn, Arg, Pro, Tyr, Lys, Phe, 0.752, 0.699, 6.8%, 0.678, 0.706; Asn, Arg, Tyr, Val, Leu, Phe, 0.752, 0.728, 1.5%, 0.722, 0.641; Asn, Arg, Tyr, Val, Lys, Trp, 0.752, 0.728, 6.4%, 0.710, 0.716; Asn, Cit, Arg, Tyr, Lys, Leu, 0.752, 0.719, 2.9%, 0.710, 0.694; Arg, Tyr, Orn, Ile, 0.752, 0.712, 4.0%, 0.727, 0.720; Asn, Cit, Met, Lys, Ile, Phe, 0.752, 0.681, 2.0%, 0.660, 0.665; Asn, Cit, Tyr, Met, Lys, Leu, 0.752, 0.721, 2.4%, 0.698, 0.669; Asn, Cit, Tyr, Orn, Ile, Leu, 0.752, 0.710, 3.1%, 0.715, 0.692; Asn, Cit, Tyr, Val, Orn, Ile, Asn, Cit, Val, Lys, Ile, Phe, 0.752, 0.680, 1.8%, 0.661, 0.665; Asn, Gln, Cit, Tyr, Met, Ile, 0.752, 0.729, 3.7%, 0.743, 0.740; Asn, Gln, Cit, Val, Lys, Leu, 0.752, 0.680, 0.2%, 0.652, 0.625; Asn, Gln, His, Arg, Tyr, Leu, 0.752, 0.732, 1.3%, 0.740 , 0.716; Asn, Gln, Orn, Lys, Leu, Trp, 0.752, 0.670, 0.2%, 0.643, 0.613; Asn, Gln, Pro, Lys, Leu, Phe, 0.752, 0.676, 0.4%, 0.654, 0.615; , Gln, Thr, Lys, Leu, T rp, 0.752, 0.681, 0.2%, 0.654, 0.627; Asn, Gln, Tyr, Met, Leu, Trp, 0.752, 0.735, 5.0%, 0.725, 0.698; Asn, Gln, Val, Met, Lys, Ile, 0.752, 0.675, 2.4%, 0.655, 0.686; Asn, Gly, Cit, Arg, Tyr, Leu, 0.752, 0.720, 3.1%, 0.708, 0.653; Asn, Gly, G

ln, Orn, Leu, Trp, 0.752, 0.675, 0.2%, 0.657, 0.590; Asn, Gly, His, Ala, Tyr, Ile, 0.752, 0.719, 5.1%, 0.718, 0.688; Lys, Ile, 0.752, 0.709, 6.6%, 0.698, 0.692; Asn, Gly, Thr, Tyr, Ile, Leu, 0.752, 0.719, 8.5%, 0.704, 0.655; Asn, Gly, Tyr, Orn, Ile, Leu, Asn, His, Arg, Lys, Ile, Leu, 0.752, 0.682, 1.8%, 0.684, 0.692; Asn, His, Arg, Met, Lys, Ile, 0.752, 0.683, 1.8%, 0.682, 0.673; Asn, His, Arg, Tyr, Lys, Leu, 0.752, 0.720, 3.5%, 0.712, 0.696; Asn, His, Cit, Arg, Orn, Ile, 0.752, 0.689, 1.5%, 0.699 , 0.651; Asn, His, Cit, Orn, Ile, Phe, 0.752, 0.681, 0.9%, 0.685, 0.623; Asn, His, Cit, Tyr, Leu, Phe, 0.752, 0.727, 1.7%, 0.723, 0.657; , His, Tyr, Ile, Leu, Phe, 0.752, 0.723, 2.9%, 0.723, 0.659; Asn, His, Tyr, Val, Ile, Phe, 0.752, 0.722, 3.5%, 0.724, 0.665; , Cit, Lys, Ile, 0.752, 0.676, 1.7%, 0.665, 0.692; Asn, Thr, Orn, Lys, Ile, Leu, 0.752, 0.678, 1.7%, 0.653, 0.657; , Trp, 0.752, 0.724, 3.9%, 0 Asn, Tyr, Met, Orn, Leu, Phe, 0.752, 0.723, 2.8%, 0.713, 0.639; Cit, Arg, Tyr, Orn, Ile, Trp, 0.752, 0.705, 5.5%, 0.716, 0.716 Cit, Tyr, Ile, Leu, Phe, Trp, 0.752, 0.718, 3.7%, 0.714, 0.673; Gln, Ala, Cit, Arg, Lys, Ile, 0.752, 0.683, 1.8%, 0.687, 0.732; Gln, Ala , Tyr, Val, Lys, Trp, 0.752, 0.728, 6.6%, 0.705, 0.726; Gln, Ala, Val, Lys, Ile, Trp, 0.752, 0.679, 1.1%, 0.662, 0.712; Gln, Arg, Tyr, Val , Leu, Phe, 0.752, 0.732, 1.5%, 0.736, 0.694; Gln, Arg, Tyr, Val, Lys, Trp, 0.752, 0.731, 4.6%, 0.714, 0.738; Gln, Cit, Pro, Tyr, Lys, Ile , 0.752, 0.718, 3.7%, 0.727, 0.789; Gln, Cit, Tyr, Met, Ile, Leu, 0.752, 0.730, 2.4%, 0.737, 0.728; Gln, Cit, Tyr, Met, Lys, Leu, 0.752, 0.726 , 2.2%, 0.716, 0.718; Gln, Cit, Tyr, Val, Lys, Ile, 0.752, 0.717, 3.3%, 0.725, 0.793; Gln, Cit, Val, Lys, Ile, Phe, 0.752, 0.677, 1.1%, Gln, His, Ala, Tyr, Leu, Phe, 0.752, 0.727, 1.8%, 0.733, 0.702; Gln, His, Ala, Tyr, Orn, Leu, 0.752, 0.720, 2.0%, 0.727, 0.757; Gln, His, Arg, Orn, Leu, Ph e, 0.752, 0.687, 0.0%, 0.683, 0.621; Gln, His, Arg, Pro, Ile, Trp, 0.752, 0.708, 1.5%, 0.727, 0.706; Gln, His, Arg, Val, Ile, Trp, 0.752, 0.709, 1.1%, 0.728, 0.702; Gln, His, Cit, Tyr, Leu, Trp, 0.752, 0.735, 3.3%, 0.732, 0.732; Gln, His, Lys, Ile, Leu, Trp, 0.752, 0.700, 1.3% , 0.696, 0.712; Gln, His, Orn, Leu, Phe, Trp, 0.752, 0.687, 0.0%, 0.678, 0.621; Gln, His, Tyr, Met, Orn, Leu, 0.752, 0.722, 2.0%, 0.728, 0.706 Gln, Orn, Ile, Leu, Phe, Trp, 0.752, 0.686, 0.2%, 0.685, 0.637; Gln, Thr, Cit, Val, Ile, Leu, 0.752, 0.698, 0.2%, 0.705, 0.690; Gln, Thr , Lys, Ile, Phe, Trp, 0.752, 0.679, 0.7%, 0.653, 0.665; Gln, Thr, Orn, Lys, Ile, Phe, 0.752, 0.678, 0.7%, 0.652, 0.661; Gln, Thr, Orn, Lys , Ile, Trp, 0.752, 0.681, 0.9%, 0.656, 0.708; Gln, Thr, Tyr, Orn, Ile, Leu, 0.752, 0.724, 4.6%, 0.729, 0.738; Gln, Thr, Tyr, Val, Ile, Leu , 0.752, 0.729, 4.6%, 0.732, 0.734; Gln, Tyr, Met, Orn, Lys, Leu, 0.752, 0.720, 2.8%, 0.705, 0.698; Gln, Tyr, Val, Lys, Ile, Leu, 0.752, 0.716 , 4.4%, 0.715, 0.750; , Tyr, Val, Met, Ile, Trp, 0.752, 0.737, 7.4%, 0.729, 0.718; Gln, Tyr, Val, Orn, Lys, Trp, 0.752, 0.727, 6.2%, 0.704, 0.722; Gly, Arg, Tyr , Lys, Leu, Phe, 0.752, 0.712, 1.5%, 0.693, 0.639; Gly, Arg, Val, Lys, Ile, Phe, 0.752, 0.671, 0.9%, 0.658, 0.669; Gly, Cit, Arg, Tyr, Ile , Phe, 0.752, 0.714, 3.9%, 0.715, 0.692; Gly, Cit, Pro, Tyr, Val, Ile, 0.752, 0.714, 5.1%, 0.705, 0.722; Gly, Cit, Tyr, Ile, Phe, Trp, 0.752 , 0.709, 5.3%, 0.707, 0.700; Gly, Cit, Tyr, Met, Lys, Ile, 0.752, 0.708, 5.0%, 0.693, 0.714; Gly, Cit, Tyr, Orn, Ile, Phe, 0.752, 0.704, 5.0 %, 0.706, 0.696; Gly, Gln, Ala, Cit, Arg, Ile, 0.752, 0.688, 1.1%, 0.695, 0.688; 0.690; Gly, Gln, Arg, Tyr, Orn, Ile, 0.752, 0.727, 5.9%, 0.731, 0.728; Gly, Gln, Cit, Tyr, Val, Leu, 0.752, 0.719, 2.4%, 0.710, 0.714; Gln, His, Thr, Met, Ile, 0.752, 0.702, 0.7%, 0.715, 0.718; Gly, Gln, His, Val, Met, Ile, 0.752, 0.702, 0.9%, 0.715, 0.710; Tyr, Met, Leu, 0.752, 0.722, 2.9%, 0.710, 0.680; Gly, Gln, Thr, Tyr, Orn, Ile, 0.752, 0.725, 7.0%, 0.727, 0.732; Gly, Gln, Thr, Tyr, Val, Phe, 0.752, 0.733, 7.5%, 0.715 , 0.669; Gly, Gln, Tyr, Orn, Ile, Phe, 0.752, 0.726, 5.3%, 0.728, 0.704; Gly, Gln, Tyr, Val, Ile, Trp, 0.752, 0.727, 8.1%, 0.717, 0.720; , His, Pro, Tyr, Ile, Phe, 0.752, 0.708, 3.5%, 0.701, 0.684; Gly, Thr, Tyr, Ile, Leu, Phe, 0.752, 0.719, 4.4%, 0.705, 0.647; His, Ala, Tyr , Orn, Ile, Phe, 0.752, 0.717, 3.1%, 0.714, 0.694; His, Arg, Lys, Ile, Phe, Trp, 0.752, 0.679, 0.4%, 0.660, 0.647; His, Thr, Cit, Tyr, Met, Ile, 0.752, 0.726, 3.7%, 0.730, 0.730; His, Thr, Tyr, Val, Ile, Phe, 0.752 , 0.727, 3.7%, 0.725, 0.680; His, Tyr, Ile, Leu, Phe, Trp, 0.752, 0.714, 3.7%, 0.698, 0.641; His, Tyr, Orn, Ile, Phe, Trp, 0.752, 0.719, 3.7 %, 0.715, 0.684; His, Tyr, Val, Ile, Phe, Trp, 0.752, 0.720, 5.1%, 0.706, 0.665; Ser, Arg, Tyr, Lys, Leu, Phe, 0.752, 0.724, 1.3%, 0.716, 0.667; Ser, Asn, Ala, Cit, Tyr, Ile, 0.752, 0.721, 4.6%, 0.727, 0.722; Ser, Asn, Cit, Arg, Tyr, Ile, 0.752, 0.723, 4.4%, 0.733, 0.726; Ser, Asn, Gln, Arg, Lys, Leu, Ser, Asn, Gln, Pro, Lys, Ile, 0.752, 0.660, 2.8%, 0.635, 0.675; Ser, Asn, Gln, Thr, Lys, Leu, 0.752, 0.674, Ser, Asn, His, Arg, Ile, Phe, 0.752, 0.672, 0.7%, 0.677, 0.637; Ser, Asn, His, Tyr, Orn, Ile, 0.752, 0.723, 4.6%, 0.727 , 0.714; Ser, Cit, Tyr, Ile, Leu, Phe, 0.752, 0.713, 3.1%, 0.714, 0.671; Ser, Gln, His, Ala, Arg, Ile, 0.752, 0.688, 0.6%, 0.705, 0.736; Ser, Gln, His, Lys, Ile, Phe, 0.752, 0.684, 0.4%, 0.675, 0.665; Ser, Gln, His Ser, Gln, His, Pro, Ile, Phe, 0.752, 0.685, 0.4%, 0.704, 0.679; Ser, Gln, His, Thr, Cit Ser, Gln, Lys, Ile, Leu, Phe, 0.752, 0.663, 1.1%, 0.637, 0.653; Ser, Gln, Lys, Ile, Leu, Trp, 0.752 , 0.664, 1.3%, 0.634, 0. 688; Ser, Gln, Tyr, Lys, Leu, Trp, 0.752, 0.724, 4.0%, 0.703, 0.736; Ser, Gln, Tyr, Met, Ile, Leu, 0.752, 0.719, 3.3%, 0.719, 0.710; Ser, Gln, Val, Met, Lys, Ile, 0.752, 0.659, 1.5%, 0.637, 0.728; Ser, Gly, Gln, His, Arg, Ile, 0.752, 0.692, 0.6%, 0.706, 0.724; Ser, Gly, Gln, His, Tyr, Val, 0.752, 0.738, 4.0%, 0.730, 0.732; Ser, Gly, Gln, Lys, Ile, Trp, 0.752, 0.663, 1.7%, 0.631, 0.688; Ser, His, Ala, Tyr, Met, Ile, 0.752, 0.721, 5.5%, 0.722, 0.712; Ser, His, Tyr, Orn, Ile, Phe, 0.752, 0.720, 2.9%, 0.715, 0.686; Ser, Thr, Tyr, Ile, Leu, Phe, 0.752, 0.722, 3.3%, 0.717, 0.677; Thr, Ala, Arg, Lys, Ile, Phe, 0.752, 0.667, 0.6% , 0.661, 0.677; Thr, Arg, Met, Lys, Ile, Phe, 0.752, 0.675, 0.7%, 0.662, 0.675; Thr, Pro, Tyr, Lys, Ile, Phe, 0.752, 0.715, 5.9%, 0.704, 0.688 Thr, Pro, Tyr, Met, Leu, Phe, 0.752, 0.721, 3.7%, 0.716, 0.647; Thr, Tyr, Val, Ile, Leu, Phe, 0.752, 0.725, 3.7%, 0.717, 0.671; Ala, Cit , Tyr, Ile, Leu, Phe, 0.751 Arg, Pro, Tyr, Met, Orn, Lys, 0.751, 0.684, 10.1%, 0.670, 0.738; Asn, Ala, Arg, Lys, Ile, Trp, 0.751, 0.671, 3.5 %, 0.668, 0.696; Asn, Ala, Cit, Arg, Lys, Ile, 0.751, 0.672, 3.1%, 0.667, 0.694; Asn, Arg, Tyr, Val, Lys, Leu, 0.751, 0.719, 3.3%, 0.709, 0.692; Asn, Cit, Arg, Tyr, Met, Ile, 0.751, 0.733, 5.3%, 0.739, 0.704; Asn, Gln, Ala, Orn, Lys, Leu, 0.751, 0.670, 0.7%, 0.646, 0.621; Gln, Ala, Tyr, Ile, Trp, 0.751, 0.732, 7.2%, 0.737, 0.726; Asn, Gln, Arg, Orn, Lys, Leu, 0.751, 0.669, 0.2%, 0.653, 0.621; Tyr, Ile, Trp, 0.751, 0.735, 5.5%, 0.746, 0.750; Asn, Gln, Cit, Tyr, Val, Leu, 0.751, 0.730, 2.0%, 0.731, 0.714; Asn, Gln, His, Cit, Orn, Leu, 0.751, 0.689, 0.9%, 0.690, 0.633; Asn, Gln, Pro, Tyr, Leu, Trp, 0.751, 0.731, 5.1%, 0.722, 0.698; Asn, Gln, Thr, Cit, Lys, Ile, 0.751, Asn, Gln, Thr, Cit, Tyr, Ile, 0.751, 0.728, 3.3%, 0.746, 0.750; Asn, Gln, Thr, Lys, Ile, Trp, 0.751, 0.679, 1.5% , 0.656, 0.680; Ala, Pro, Tyr, Leu, 0.751, 0.713, 2.4%, 0.695, 0.647; Asn, Gly, Ala, Tyr, Val, Leu, 0.751, 0.713, 2.4%, 0.696, 0.647; Asn, Gly, Gln, Ala, Cit, Ile, 0.751, 0.686, 1.3%, 0.696, 0.679; Asn, Gly, Gln, Ile, Leu, Phe, 0.751, 0.686, 0.2%, 0.686, 0.627; Asn, Gly, Gln, Val, Orn, Leu, Asn, Gly, His, Tyr, Ile, Trp, 0.751, 0.717, 4.4%, 0.716, 0.700; Asn, Gly, Thr, Arg, Tyr, Ile, 0.751, 0.723, 5.9%, 0.723, 0.686; Asn, Gly, Thr, Orn, Lys, Ile, 0.751, 0.677, 2.0%, 0.650, 0.659; Asn, His, Ala, Cit, Ile, Leu, 0.751, 0.701, 1.5%, 0.710 , 0.665; Asn, His, Ala, Lys, Ile, Phe, 0.751, 0.680, 1.7%, 0.666, 0.671; Asn, His, Arg, Met, Ile, Phe, 0.751, 0.692, 0.0%, 0.697, 0.625; Asn, His, Met, Lys, Ile, Leu, 0.751, 0.688, 3.7%, 0.665, 0.633; Asn, His, Pro , Tyr, Lys, Ile, 0.751, 0.715, 4.8%, 0.707, 0.696; Asn, His, Thr, Met, Lys, Ile, 0.751, 0.688, 3.3%, 0.666, 0.625; , Leu, 0.751, 0.710, 5.5%, Asn, His, Tyr, Orn, Ile, Leu, 0.751, 0.725, 4.8%, 0.725, 0.694; Asn, His, Val, Ile, Phe, Trp, 0.751, 0.692, 0.4%, 0.694, 0.623; Asn, Thr, Arg, Tyr, Leu, Phe, 0.751, 0.733, 2.2%, 0.730, 0.651; Asn, Thr, Cit, Lys, Ile, Phe, 0.751, 0.680, 1.8%, 0.660, 0.663; Asn, Thr, Val, Lys, Ile, Leu, 0.751, 0.675, 1.3%, 0.649, 0.651; Cit, Tyr, Val, Lys, Ile, Trp, 0.751, 0.715, 5.1%, 0.699, 0.718; Gln, Ala, Cit, Val, Ile, Leu, 0.751, 0.693, 0.7%, 0.704, 0.682; Gln, Ala, Pro, Tyr, Leu, Phe, 0.751, 0.722, 2.0%, 0.723, 0.686; Gln, Ala, Tyr, Orn, Leu, Trp, Gln, Arg, Pro, Lys, Ile, Phe, 0.751, 0.676, 1.3%, 0.667, 0.671; Gln, Cit, Lys, Ile, Leu, Trp, 0.751, 0.689, 0.4%, 0.675, 0.710; Gln, Cit, Lys, Ile, Phe, Trp, 0.751, 0.679, 0.6%, 0.665, 0.669; Gln, Cit, Orn, Ile, Leu, Phe, 0.751, 0.682, 0.9%, 0.680 , 0.627; Gln, Cit, Pro, Tyr, Orn, Ile, 0.751, 0.707, 3.5%, 0.724, 0.740; Gln, His, Ala, Arg, Orn, Ile, 0.751, 0.693, 0.9%, 0.719, 0.714; , His, Ala, Lys, Ile, T rp, 0.751, 0.701, 1.8%, 0.694, 0.710; Gln, His, Ala, Met, Ile, Leu, 0.751, 0.705, 0.9%, 0.721, 0.710; Gln, His, Ala, Pro, Tyr, Leu, 0.751, 0.726, 2.4%, 0.730, 0.750; Gln, His, Ala, Tyr, Lys, Ile, 0.751, 0.722, 3.3%, 0.729, 0.775; Gln, His, A

rg, Ile, Leu, Trp, 0.751, 0.708, 1.1%, 0.725, 0.700; Gln, His, Arg, Met, Ile, Leu, 0.751, 0.710, 0.4%, 0.731, 0.704; Gln, His, Arg, Pro, Tyr, Lys, 0.751, 0.727, 1.8%, 0.740, 0.785; Gln, His, Cit, Pro, Lys, Ile, 0.751, 0.696, 2.0%, 0.698, 0.726; Gln, His, Pro, Lys, Ile, Phe, Gln, His, Pro, Met, Orn, Ile, 0.751, 0.694, 1.3%, 0.713, 0.698; Gln, His, Thr, Ala, Val, Ile, 0.751, 0.705, 1.1%, 0.727, 0.736; Gln, His, Thr, Arg, Pro, Ile, 0.751, 0.706, 0.7%, 0.733, 0.736; Gln, His, Thr, Arg, Val, Ile, 0.751, 0.707, 0.7%, 0.733 , 0.730; Gln, His, Thr, Met, Ile, Trp, 0.751, 0.707, 0.7%, 0.726, 0.720; Gln, His, Tyr, Val, Phe, Trp, 0.751, 0.739, 3.3%, 0.738, 0.704; , His, Val, Ile, Leu, Trp, 0.751, 0.709, 1.5%, 0.720, 0.702; Gln, Orn, Lys, Ile, Phe, Trp, 0.751, 0.677, 0.6%, 0.654, 0.665; Gln, Pro, Tyr , Met, Ile, Leu, 0.751, 0.730, 4.4%, 0.731, 0.706; Gln, Pro, Tyr, Val, Lys, Trp, 0.751, 0.728, 6.6%, 0.704, 0.730; Gln, Thr, Ala, Arg, Lys , Ile, 0.751, 0.685, 0.9%, 0 .687, 0.724; Gln, Thr, Arg, Tyr, Ile, Phe, 0.751, 0.726, 4.2%, 0.740, 0.708; Gln, Thr, Val, Lys, Ile, Trp, 0.751, 0.679, 1.1%, 0.657, 0.716 Gln, Val, Lys, Ile, Leu, Trp, 0.751, 0.679, 0.7%, 0.660, 0.700; Gly, Arg, Tyr, Val, Met, Lys, 0.751, 0.723, 4.4%, 0.700, 0.692; Gly, Cit , Pro, Tyr, Lys, Ile, 0.751, 0.701, 5.0%, 0.695, 0.736; Gly, Cit, Tyr, Lys, Ile, Phe, 0.751, 0.705, 5.0%, 0.695, 0.706; Gly, Gln, Cit, Lys , Ile, Leu, 0.751, 0.679, 0.6%, 0.662, 0.708; Gly, Gln, Cit, Orn, Ile, Trp, 0.751, 0.680, 2.0%, 0.678, 0.671; Gly, Gln, Cit, Tyr, Lys, Ile , 0.751, 0.710, 3.5%, 0.706, 0.753; Gly, Gln, Cit, Tyr, Orn, Leu, 0.751, 0.702, 2.4%, 0.696, 0.714; Gly, Gln, His, Ala, Pro, Ile, 0.751, 0.702 , 1.1%, 0.718, 0.716; Gly, Gln, His, Ala, Val, Ile, 0.751, 0.701, 0.9%, 0.718, 0.724; Gly, Gln, His, Arg, Orn, Ile, 0.751, 0.694, 0.7%, 0.716, 0.700; Gly, Gln, His, Arg, Val, Ile, 0.751, 0.704, 0.9%, 0.725, 0.712; Gly, Gln, His, Cit, Lys, Ile, 0.751, 0.692, 1.1%, 0.690, 0.718; Gly, Gln, Met, Orn, Lys, Il e, 0.751, 0.677, 0.7%, 0.650, 0.694; Gly, Gln, Pro, Tyr, Met, Ile, 0.751, 0.724, 5.7%, 0.722, 0.720; Gly, Gln, Thr, Met, Lys, Ile, 0.751, 0.674, 0.7%, 0.646, 0.692; Gly, Gln, Val, Lys, Ile, Trp, 0.751, 0.672, 0.9% , 0.647, 0.696; Gly, His, Cit, Tyr, Val, Ile, 0.751, 0.715, 3.7%, 0.712, 0.744; Gly, Thr, Tyr, Lys, Ile, Phe, 0.751, 0.711, 5.5%, 0.693, 0.680 Gly, Tyr, Ile, Leu, Phe, Trp, 0.751, 0.710, 4.2%, 0.691, 0.633; Gly, Tyr, Val, Met, Ile, Phe, 0.751, 0.722, 6.1%, 0.703, 0.665; His, Thr , Ala, Tyr, Met, Ile, 0.751, 0.725, 5.5%, 0.730, 0.712; His, Thr, Arg, Tyr, Lys, Ile, 0.751, 0.717, 8.3%, 0.717, 0.744; , Met, Ile, 0.751, 0.730, 5.1%, 0.738, 0.714; His, Thr, Pro, Tyr, Met, Ile, 0.751, 0.726, 5.0%, 0.728, 0.698; Ser, Arg, Val, Lys, Ile, Phe, 0.751, 0.655, 1.3%, 0.636, 0.653; Ser, Asn, Arg, Pro, Tyr, Lys, 0.751, 0.708 , 7.4%, 0.693, 0.734; , Asn, Arg, Tyr, Leu, Phe, 0.751, 0.729, 1.5%, 0.725, 0.639; Ser, Asn, Cit, Tyr, Ile, Phe, 0.751, 0.721, 4.6%, 0.728, 0.688; , Ala, Lys, Ile, 0.751, 0.661, 3.3%, 0.638, 0.682; Ser, Asn, Gln, Tyr, Ile, Trp, 0.751, 0.713, 4.6%, 0.715, 0.732; , Ile, 0.751, 0.715, 4.8%, 0.715, 0.692; Ser, Asn, Pro, Tyr, Leu, Phe, 0.751, 0.723, 2.4%, 0.714, 0.641; Ser, Asn, Tyr, Leu, Phe, Trp, 0.751 Ser, Gln, Met, Lys, Ile, Phe, 0.751, 0.660, 1.5%, 0.636, 0.671; Ser, Gln, Met, Lys, Ile, Trp, 0.751, 0.662, 1.5 %, 0.632, 0.692; Ser, Gln, Thr, Tyr, Ile, Trp, 0.751, 0.712, 8.1%, 0.713, 0.757; Ser, Gln, Thr, Tyr, Lys, Leu, 0.751, 0.715, 3.9%, 0.706, Ser, Gln, Tyr, Val, Leu, Trp, 0.751, 0.722, 4.8%, 0.707, 0.712; Ser, Gly, Cit, Tyr, Ile, Phe, 0.751, 0.715, 4.4%, 0.713, 0.700; Ser, Gly, Gln, Tyr, Val, Phe, 0.751, 0.737, 5.9%, 0.719, 0.673; Ser, Gly, His, Tyr, Met, Ile, 0.751, 0.724, 4.4%, 0.718, 0.694; Ser, His, Arg, Tyr, Met, Ile, 0.751, 0.720, 5.5%, 0.727, 0.720; Ser, His, Tyr, Ile, Leu, Phe, 0.751, 0.717, 2.8%, 0.708 , 0.661; Ser, His, Tyr, Met, Orn, Ile, 0.751, 0.723, 5.5%, 0.723, 0.716; Thr, Arg, Lys, Ile, Phe, Trp, 0.751, 0.671, 0.7%, 0.657, 0.667; , Arg, Tyr, Val, Lys, Ile, 0.751, 0.716, 7.4%, 0.714, 0.740; Thr, Cit, Arg, Tyr, Ile, Phe, 0.751, 0.725, 4.4%, 0.735, 0.698; Thr, Tyr, Ile , Leu, Phe, Trp, 0.751, 0.725, 4.4%, 0.717, 0.663; Thr, Tyr, Met, Lys, Leu, Phe, 0.751, 0.723, 3.1%, 0.705, 0.653; Tyr, Lys, Ile, Leu, Phe , Trp, 0.751, 0.711, 4.2%, 0.691, 0.649; Ala, Arg, Tyr, Lys, Leu, Trp, 0.750, 0.709, 2.8%, 0.694, 0.694; Arg, Pro, Orn, Lys, Ile, Phe, 0.750 Arg, Tyr, Orn, Lys, Leu, Phe, 0.750, 0.707, 1.7%, 0.700, 0.669; Asn, Ala, Cit, Lys, Ile, Trp, 0.750, 0.676, 2.0 %, 0.666, 0.694; Asn, Ala, Cit, Met, Lys, Ile, 0.750, 0.676, 2.0%, 0.667, 0.692; Asn, Ala, Tyr, Lys, Leu, Trp, 0.750, 0.714, 3.5%, 0.691, 0.665; Asn, Arg, Pro, Lys, Ile, Leu, 0.750, 0.673, 2.8%, 0.662, 0.661; Asn, Cit, Orn, Lys, Ile, Trp, 0.750, 0.670, 2.0%, 0.657, 0.661; Asn, Gln, Val, Lys, Ile, Trp, Asn, Gly, Ala, Arg, Tyr, Ile, 0.750, 0.723, 5.9%, 0.718, 0.682; Asn, Gly, Tyr, Val, Leu, Phe, 0.750, 0.716, 2.4%, 0.696, 0.623; Asn, Thr, Arg, Pro, Lys, Ile, 0.750, 0.671, 2.9%, 0.659, 0.667; Asn, Thr, Cit, Tyr, Met, Ile, 0.750, 0.733, 5.1%, 0.738 , 0.706; Asn, Thr, Val, Met, Lys, Ile, 0.750, 0.678, 2.6%, 0.651, 0.659; Gln, Arg, Pro, Tyr, Ile, Phe, 0.750, 0.725, 3.9%, 0.740, 0.706; , Cit, Tyr, Met, Orn, Leu, 0.750, 0.712, 2.2%, 0.713, 0.708; Gln, His, Cit, Arg, Lys, Ile, 0.750, 0.697, 0.7%, 0.705, 0.716; Gln, His, Met , Orn, Ile, Trp, 0.750, 0.699, 1.8%, 0.718, 0.698; Gln, His, Pro, Val, Ile, Trp, 0.750, 0.707, 1.5%, 0.723, 0.710; , Trp, 0.750, 0.697, 1.3%, 0.692, 0.706; Gln, Pro, Tyr, Val, Ile, Trp, 0.750, 0.738, 8.5%, 0.726, 0.732; Gln, Thr, Ala, Tyr, Leu, Phe, 0.750 , 0.724, 1.7%, 0.731, 0. Gln, Thr, Cit, Ile, Leu, Phe, 0.750, 0.687, 0.2%, 0.691, 0.671; Gln, Thr, Tyr, Val, Lys, Leu, 0.750, 0.719, 4.0%, 0.707, 0.730; Tyr, Val, Orn, Ile, Leu, 0.750, 0.722, 3.9%, 0.728, 0.742; Gly, Cit, Tyr, Val, Met, Ile, 0.750, 0.722, 6.6%, 0.710, 0.696; Gly, Gln, Ala, Tyr, Orn, Ile, 0.750, 0.729, 5.9%, 0.728, 0.738; Gly, Gln, His, Arg, Pro, Ile, 0.750, 0.702, 0.9%, 0.725, 0.712; Gly, Gln, Thr, Lys, Ile, Phe, 0.750, 0.671, 0.7%, 0.642, 0.657; Gly, Thr, Tyr, Lys, Leu, Phe, 0.750, 0.714, 3.1%, 0.697, 0.627; Gly, Tyr, Lys, Ile, Leu, Phe, 0.750, His, Arg, Orn, Ile, Leu, Phe, 0.750, 0.675, 0.0%, 0.672, 0.613; Ser, Arg, Orn, Lys, Ile, Phe, 0.750, 0.655, 1.3% , 0.639, 0.659; Ser, Asn, Gln, Tyr, Orn, Ile, 0.750, 0.720, 5.0%, 0.726, 0.744; Ser, Asn, Lys, Ile, Leu, Phe, 0.750, 0.662, 1.8%, 0.630, 0.631 Ser, Cit, Tyr, Val, Orn, Ile, 0.750, 0.709, 5.5%, 0.713, 0.730; Ser, Gln, Ala, Tyr, Leu, Trp, 0.750, 0.717, 3.9%, 0.705, 0.712; Ser, Gln , Cit, Tyr, Orn, Ile, 0.750 Ser, Gln, Cit, Tyr, Val, Ile, 0.750, 0.717, 3.9%, 0.729, 0.757; Ser, Gln, His, Arg, Ile, Leu, 0.750, 0.691, 0.6 %, 0.708, 0.740; Ser, Gln, His, Pro, Tyr, Leu, 0.750, 0.725, 2.8%, 0.731, 0.748; Ser, Gln, His, Tyr, Val, Leu, 0.750, 0.729, 2.2%, 0.730, Ser, Gln, His, Val, Lys, Ile, 0.750, 0.678, 1.7%, 0.674, 0.738; Ser, Gln, Tyr, Met, Leu, Trp, 0.750, 0.727, 4.2%, 0.715, 0.704; Ser, Ser, Gly, Gln, His, Cit, Ile, 0.750, 0.691, 0.7%, 0.703, 0.716; Ser, Gly, His, Arg, Tyr, Ile, 0.750, 0.716, 3.1%, 0.722, 0.724; Ser, His, Pro, Tyr, Met, Ile, 0.750, 0.722, 5.5%, 0.724, 0.714; Thr, Ala, Tyr, Lys, Ile, Phe, 0.750, 0.712, 5.5%, 0.703, 0.690; Tyr, Met, Ile, Leu, Phe, Trp, 0.750, 0.722, 4.8%, 0.710, 0.657; Ala, Arg, Orn, Lys, Ile, Phe, 0.750, 0.662, 0.7%, 0.658, 0.673; Ala, Cit, Arg, Lys, Ile, Phe, 0.750, 0.669, 0.7%, 0.663, 0.673; Ala, Tyr, Lys, Ile, Leu, Phe, 0.750, 0.707, 4.4% , 0.695, 0.669; Arg, Pro, T yr, Lys, Leu, Phe, 0.750, 0.707, 1.3%, 0.698, 0.657; Asn, Arg, Tyr, Val, Orn, Lys, 0.750, 0.713, 3.5%, 0.703, 0.708; Asn, Cit, Pro, Tyr, Met, Ile, 0.750, 0.732, 5.1%, 0.736, 0.704; Asn, Gln, Ala, Cit, Ile, Leu, 0.750, 0.693, 0.6%, 0.705, 0.679; Asn, Gln, Cit, Arg, Tyr, Ile, Asn, Gln, Cit, Pro, Tyr, Ile, 0.750, 0.729, 3.5%, 0.745, 0.744; Asn, Gln, Thr, Arg, Leu, Phe, 0.750, 0.680, 0.0%, 0.675, 0.611; Asn, Gly, Gln, Cit, Pro, Ile, 0.750, 0.689, 0.7%, 0.692, 0.669; Asn, Gly, Gln, His, Orn, Leu, 0.750, 0.687, 0.9%, 0.682 , 0.621; Asn, Gly, Gln, Tyr, Val, Trp, 0.750, 0.731, 8.5%, 0.708, 0.690; Asn, Gly, His, Cit, Tyr, Leu, 0.750, 0.717, 2.6%, 0.705, 0.657; Asn, Gly, Thr, Met, Lys, Ile, 0.750, 0.674, 2.6%, 0.648, 0.659; Asn, Gly, Thr , Tyr, Met, Leu, 0.750, 0.722, 6.2%, 0.703, 0.633; Asn, Gly, Thr, Val, Lys, Ile, 0.750, 0.674, 2.4%, 0.645, 0.651; , Phe, 0.750, 0.688, 0.2%, 0 Asn, His, Arg, Tyr, Leu, Phe, 0.750, 0.730, 1.5%, 0.730, 0.659; Asn, His, Arg, Tyr, Orn, Leu, 0.750, 0.716, 3.1%, 0.718, 0.671 Asn, His, Met, Ile, Phe, Trp, 0.750, 0.693, 0.4%, 0.697, 0.623; Asn, His, Pro, Tyr, Ile, Leu, 0.750, 0.723, 3.9%, 0.723, 0.698; Asn, His , Pro, Tyr, Orn, Ile, 0.750, 0.729, 3.7%, 0.735, 0.714; Asn, His, Tyr, Met, Lys, Leu, 0.750, 0.725, 4.2%, 0.708, 0.665; Asn, His, Tyr, Val, Orn, Ile, 0.750, 0.729, 5.0%, 0.730, 0.702; Asn, His, Val, Met, Lys, Ile Asn, Thr, Lys, Ile, Leu, Trp, 0.750, 0.677, 1.5%, 0.653, 0.659; Gln, Ala, Cit, Val, Lys, Ile, 0.750, 0.679 , 1.3%, 0.676, 0.734; Gln, Ala, Tyr, Orn, Leu, Phe, 0.750, 0.717, 2.4%, 0.720, 0.686; Gln, Ala, Tyr, Val, Ile, Trp, 0.750, 0.735, 7.5%, Gln, Arg, Tyr, Met, Orn, Leu, 0.750, 0.718, 3.5%, 0.720, 0.696; Gln, Cit, Tyr, Met, Leu, Trp, 0.750, 0.731, 3.3%, 0.724, 0.720; Gln, Cit, Tyr, Orn, Lys, Il e, 0.750, 0.704, 3.7%, 0.709, 0.777; Gln, His, Ala, Cit, Lys, Ile, 0.750, 0.697, 1.3%, 0.701, 0.736; Gln, His, Ala, Lys, Ile, Phe, 0.750, 0.689, 0.6%, 0.686, 0.671; Gln, His, Ala, Tyr, Val, Leu, 0.750, 0.724, 2.2%, 0.728, 0.751; Gln, His, Ar

g, Val, Met, Ile, 0.750, 0.710, 0.2%, 0.732, 0.708; Gln, His, Pro, Tyr, Val, Trp, 0.750, 0.737, 4.2%, 0.728, 0.736; Ile, Leu, 0.750, 0.707, 0.7%, 0.730, 0.730; Gln, Met, Lys, Ile, Leu, Trp, 0.750, 0.686, 0.7%, 0.657, 0.694; Gln, Met, Lys, Ile, Phe, Trp, Gln, Pro, Tyr, Met, Ile, Trp, 0.750, 0.736, 7.7%, 0.739, 0.744; Gln, Thr, Arg, Lys, Ile, Leu, 0.750, 0.684, 1.1%, 0.683, 0.720; Gln, Thr, Tyr, Met, Ile, Leu, 0.750, 0.730, 3.7%, 0.732, 0.712; Gln, Thr, Tyr, Orn, Leu, Trp, 0.750, 0.721, 7.7%, 0.711 Gln, Thr, Val, Lys, Leu, Phe, 0.750, 0.678, 0.0%, 0.648, 0.625; Gln, Tyr, Orn, Lys, Leu, Trp, 0.750, 0.719, 4.2%, 0.700, 0.720; , Ala, Cit, Tyr, Ile, Phe, 0.750, 0.710, 4.6%, 0.710, 0.704; Gly, Gln, Ala, Tyr, Orn, Leu, 0.750, 0.717, 2.8%, 0.708, 0.708; Gly, Gln, Cit , Pro, Tyr, Leu, 0.750, 0.717, 2.9%, 0.712, 0.714; Gly, Gln, His, Arg, Ile, Trp, 0.750, 0.702, 1.1%, 0.716, 0.692; Gly, Gln, His, Arg, Met , Ile, 0.750, 0.704, 0.9%, 0. 722, 0.710; Gly, Gln, His, Met, Lys, Ile, 0.750, 0.689, 0.9%, 0.678, 0.696; Gly, Gln, Met, Lys, Ile, Trp, 0.750, 0.676, 0.7%, 0.645, 0.690; Gly, Gln, Pro, Tyr, Val, Ile, 0.750, 0.724, 5.9%, 0.720, 0.726; Gly, Gln, Thr, Orn, Lys, Ile, 0.750, 0.678, 0.7%, 0.650, 0.696; Tyr, Val, Met, Phe, 0.750, 0.726, 6.8%, 0.706, 0.673; Gly, Thr, Cit, Tyr, Met, Ile, 0.750, 0.718, 8.6%, 0.709, 0.704; His, Arg, Lys, Ile, Leu, Phe, 0.750, 0.679, 0.6%, 0.664, 0.661; His, Arg, Met, Lys, Ile, Leu, 0.750, 0.683, 1.1%, 0.671, 0.679; His, Cit, Pro, Tyr, Lys, Ile, Ser, Arg, Met, Lys, Ile, Trp, 0.750, 0.656, 2.8%, 0.635, 0.682; Ser, Arg, Tyr, Ile, Leu, Trp, 0.750, 0.707, Ser, Asn, Arg, Val, Lys, Ile, 0.750, 0.648, 2.9%, 0.637, 0.667; Ser, Asn, Gln, Met, Lys, Leu, 0.750, 0.675, 0.2%, 0.645 , 0.639; Ser, Asn, Gln, Pro, Tyr, Ile, 0.750, 0.714, 4.6%, 0.722, 0.736; Ser, Asn, His, Lys, Ile, Trp, 0.750, 0.670, 3.5%, 0.652, 0.669; , Asn, Thr, Tyr, Ile, Leu Ser, Gln, Arg, Tyr, Ile, Leu, 0.750, 0.716, 3.1%, 0.725, 0.744; Ser, Gln, Arg, Tyr, Leu, Phe, 0.750, 0.732 , 1.7%, 0.736, 0.692; Ser, Gln, His, Cit, Lys, Ile, 0.750, 0.684, 0.7%, 0.681, 0.730; Ser, Gln, His, Thr, Ile, Phe, 0.750, 0.689, 0.4%, Ser, Gln, Thr, Lys, Leu, Phe, 0.750, 0.673, 0.2%, 0.642, 0.617; Ser, Gln, Tyr, Val, Lys, Trp, 0.750, 0.729, 6.4%, 0.707, 0.730; Ser, His, Tyr, Met, Ile, Leu, 0.750, 0.724, 5.1%, 0.720, 0.700; Ser, Thr, Arg, Lys, Ile, Trp, 0.750, 0.653, 2.8%, 0.630, 0.688; Ser, Thr, Cit, Tyr, Ile, Phe, 0.750, 0.715, 4.6%, 0.724, 0.698; Ser, Tyr, Met, Ile, Leu, Phe, 0.750, 0.720, 4.4%, 0.709, 0.659; Thr, Arg, Tyr, Lys, Leu, Phe, 0.750, 0.724, 2.4%, 0.720, 0.665; Thr, Arg, Val, Lys, Ile, Phe, 0.750, 0.673, 0.7%, 0.661, 0.671; Thr, Tyr, Lys, Leu, Phe, Trp, 0.750, 0.723, 3.3%, 0.705, 0.655

Claims (19)

  1. 　評価対象の血液中のAla、Arg、Asn、Cit、Gln、Gly、His、Ile、Leu、Lys、Met、Orn、Phe、Pro、Ser、Thr、Trp、Tyr、およびValの濃度値、前記血液中の3h-Kyn、5h-Indole-3-acetic　acid、Anthranilic　acid、Indol-3-acetic　acid、Indole-3-lactic　acid、Kynurenic　acid、Picolinic　acid、Quinolinic　acid、Serotonin、Xanthurenic　acid、Neopterin、1-Mehis、3-Mehis、ADMA、b-AiBA、Cystathionine、GABA、hArg、Kyn、N6-acetyl-L-lysine、N8-acetyl-spd、SDMA、Thioproline、aABA、およびSpdの値、前記血液中のWBC、RBC、Hb、Ht、葉酸、LDLC、Alb、プレアルブミン、CRP、TG、尿酸、γGTP、およびHbA1cの検査値、ならびに前記評価対象のBMI（Body　Mass　Index）および体重の値のうちの少なくとも１つの値、または、前記少なくとも１つの値が代入される変数を含む式および前記少なくとも１つの値を用いて算出された前記式の値を用いて、前記評価対象について認知症の将来の発症リスクを評価する評価ステップを含むこと、
    　を特徴とする評価方法。     Concentration values of Ala, Arg, Asn, Cit, Gln, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, and Val in the blood to be evaluated, the blood 3h-Kyn, 5h-Indole-3-acetic acid, Anthranilic acid, Indol-3-acetic acid, Indole-3-lactic acid, Kynurenic acid, Picolinic acid, Quinolinic acid, Serotonin, Xanthurenic acid, Neopterin, 1- Values of Mehis, 3-Mehis, ADMA, b-AiBA, Cystathionine, GABA, hArg, Kyn, N6-acetyl-L-lysine, N8-acetyl-spd, SDMA, Thioproline, aABA, and Spd, WBC in said blood , RBC, Hb, Ht, folic acid, LDLC, Alb, prealbumin, CRP, TG, uric acid, γGTP, and HbA1c test values, and at least one of the BMI (Body Mass Index) and body weight values of the subject to be evaluated One value, or a formula containing a variable to which the at least one value is assigned and the value of the formula calculated using the at least one value, dementia for the subject to be evaluated. including an evaluation step to evaluate;
    An evaluation method characterized by
  2. 　前記評価ステップは、Val、Leu、およびIleの前記濃度値の合計ならびにＡＰＯＥアリルの保有に関するカテゴリカル変数の値、または、前記合計が代入される変数と前記カテゴリカル変数の前記値が代入される変数とを含む式、前記合計、および前記カテゴリカル変数の前記値を用いて算出された前記式の値、を用いて、前記評価対象について認知症の将来の発症リスクを評価するものであること、
    　を特徴とする請求項１に記載の評価方法。     Said evaluation step assigns the sum of said concentration values of Val, Leu, and Ile and the value of a categorical variable relating to the possession of the APOE allele, or the variable to which said sum is assigned and said value of said categorical variable. A formula containing a variable, the sum, and the value of the formula calculated using the values of the categorical variables to evaluate the risk of future development of dementia for the subject. ,
    The evaluation method according to claim 1, characterized by:
  3. 　前記評価対象の生体サンプルを用いてＡｐｏＥ遺伝子を検査する検査ステップと、
    　前記検査ステップで得られたＡｐｏＥの遺伝型を基に前記カテゴリカル変数の値を決定する決定ステップと、
    をさらに含み、
    　前記評価ステップにおいて、前記カテゴリカル変数の前記値は、前記決定ステップで決定した前記値であること、
    　を特徴とする請求項２に記載の評価方法。     an inspection step of inspecting the ApoE gene using the biological sample to be evaluated;
    a determination step of determining the value of the categorical variable based on the ApoE genotype obtained in the examination step;
    further comprising
    wherein, in the evaluating step, the value of the categorical variable is the value determined in the determining step;
    The evaluation method according to claim 2, characterized by:
  4. 　前記評価対象は、ＡＰＯＥε４アリルを保有しないものであり、
    　前記評価ステップは、Ala、Arg、Asn、Cit、Gln、Gly、His、Ile、Leu、Lys、Met、Orn、Phe、Pro、Ser、Thr、Trp、Tyr、およびValの前記濃度値ならびにVal、Leu、およびIleの前記濃度値の合計のうちの少なくとも１つの値、または、前記少なくとも１つの値が代入される変数を含む式および前記少なくとも１つの値を用いて算出された前記式の値を用いて、前記評価対象について認知症の将来の発症リスクを評価するものであること、
    　を特徴とする請求項１に記載の評価方法。     The subject to be evaluated does not possess the APOE ε4 allele,
    Said evaluation step includes said concentration values of Ala, Arg, Asn, Cit, Gln, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, and Val and Val, At least one value of the sum of the concentration values of Leu and Ile, or a formula including variables into which the at least one value is substituted and the value of the formula calculated using the at least one value using to evaluate the future risk of developing dementia for the evaluation subject,
    The evaluation method according to claim 1, characterized by:
  5. 　前記評価対象の生体サンプルを用いてＡｐｏＥ遺伝子を検査する検査ステップと、
    　前記検査ステップで得られたＡｐｏＥの遺伝型を基にＡＰＯＥε４アリルを保有しているか否か確認する確認ステップと、
    　をさらに含み、
    　前記評価ステップにおいて、前記評価対象は、前記確認ステップでＡＰＯＥε４アリルを保有していないと確認されたものであること、
    　を特徴とする請求項４に記載の評価方法。     an inspection step of inspecting the ApoE gene using the biological sample to be evaluated;
    a confirmation step of confirming whether or not the ApoE genotype obtained in the examination step has the APOE ε4 allele;
    further comprising
    In the evaluation step, the evaluation target is confirmed not to possess the APOE ε4 allele in the confirmation step;
    The evaluation method according to claim 4, characterized by:
  6. 　前記評価ステップは、制御部を備える情報処理装置の前記制御部において実行されること、
    　を特徴とする請求項１から５のいずれか一つに記載の評価方法。     the evaluation step being executed by the control unit of an information processing device comprising a control unit;
    The evaluation method according to any one of claims 1 to 5, characterized by:
  7. 　評価対象の血液中のAla、Arg、Asn、Cit、Gln、Gly、His、Ile、Leu、Lys、Met、Orn、Phe、Pro、Ser、Thr、Trp、Tyr、およびValの濃度値、前記血液中の3h-Kyn、5h-Indole-3-acetic　acid、Anthranilic　acid、Indol-3-acetic　acid、Indole-3-lactic　acid、Kynurenic　acid、Picolinic　acid、Quinolinic　acid、Serotonin、Xanthurenic　acid、Neopterin、1-Mehis、3-Mehis、ADMA、b-AiBA、Cystathionine、GABA、hArg、Kyn、N6-acetyl-L-lysine、N8-acetyl-spd、SDMA、Thioproline、aABA、およびSpdの値、前記血液中のWBC、RBC、Hb、Ht、葉酸、LDLC、Alb、プレアルブミン、CRP、TG、尿酸、γGTP、およびHbA1cの検査値、ならびに前記評価対象のBMI（Body　Mass　Index）および体重の値のうちの少なくとも１つの値、ならびに、前記少なくとも１つの値が代入される変数を含む認知症の将来の発症リスクを評価するための式を用いて、前記式の値を算出する算出ステップを含むこと、
    　を特徴とする算出方法。     Concentration values of Ala, Arg, Asn, Cit, Gln, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, and Val in the blood to be evaluated, the blood 3h-Kyn, 5h-Indole-3-acetic acid, Anthranilic acid, Indol-3-acetic acid, Indole-3-lactic acid, Kynurenic acid, Picolinic acid, Quinolinic acid, Serotonin, Xanthurenic acid, Neopterin, 1- Values of Mehis, 3-Mehis, ADMA, b-AiBA, Cystathionine, GABA, hArg, Kyn, N6-acetyl-L-lysine, N8-acetyl-spd, SDMA, Thioproline, aABA, and Spd, WBC in said blood , RBC, Hb, Ht, folic acid, LDLC, Alb, prealbumin, CRP, TG, uric acid, γGTP, and HbA1c test values, and at least one of the BMI (Body Mass Index) and body weight values of the subject to be evaluated using a formula for assessing the risk of future development of dementia that includes one value and a variable into which said at least one value is substituted, and calculating the value of said formula;
    A calculation method characterized by
  8. 　前記算出ステップは、Val、Leu、およびIleの前記濃度値の合計、ＡＰＯＥアリルの保有に関するカテゴリカル変数の値、ならびに前記合計が代入される変数と前記カテゴリカル変数の前記値が代入される変数とを含む認知症の将来の発症リスクを評価するための式を用いて、前記式の値を算出するものであること、
    　を特徴とする請求項７に記載の算出方法。     Said calculating step comprises: sum of said concentration values of Val, Leu, and Ile; values of categorical variables relating to possession of APOE allele; Using a formula for evaluating the risk of future onset of dementia including and to calculate the value of the formula,
    The calculation method according to claim 7, characterized by:
  9. 　前記評価対象は、ＡＰＯＥε４アリルを保有しないものであり、
    　前記算出ステップは、Ala、Arg、Asn、Cit、Gln、Gly、His、Ile、Leu、Lys、Met、Orn、Phe、Pro、Ser、Thr、Trp、Tyr、およびValの前記濃度値ならびにVal、Leu、およびIleの前記濃度値の合計のうちの少なくとも１つの値、ならびに、前記少なくとも１つの値が代入される変数を含む認知症の将来の発症リスクを評価するための式を用いて、前記式の値を算出するものであること、
    　を特徴とする請求項７に記載の算出方法。     The subject to be evaluated does not possess the APOE ε4 allele,
    Said calculating step includes said concentration values of Ala, Arg, Asn, Cit, Gln, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, and Val and Val, At least one value of the sum of the concentration values of Leu and Ile, and a formula for evaluating the future onset risk of dementia comprising a variable into which the at least one value is substituted, that it calculates the value of the formula;
    The calculation method according to claim 7, characterized by:
  10. 　前記算出ステップは、制御部を備える情報処理装置の前記制御部において実行されること、
    　を特徴とする請求項７から９のいずれか一つに記載の算出方法。     the calculating step is executed by the control unit of an information processing device comprising a control unit;
    10. The calculation method according to any one of claims 7 to 9, characterized by:
  11. 　制御部を備える評価装置であって、
    　前記制御部は、
    　評価対象の血液中のAla、Arg、Asn、Cit、Gln、Gly、His、Ile、Leu、Lys、Met、Orn、Phe、Pro、Ser、Thr、Trp、Tyr、およびValの濃度値、前記血液中の3h-Kyn、5h-Indole-3-acetic　acid、Anthranilic　acid、Indol-3-acetic　acid、Indole-3-lactic　acid、Kynurenic　acid、Picolinic　acid、Quinolinic　acid、Serotonin、Xanthurenic　acid、Neopterin、1-Mehis、3-Mehis、ADMA、b-AiBA、Cystathionine、GABA、hArg、Kyn、N6-acetyl-L-lysine、N8-acetyl-spd、SDMA、Thioproline、aABA、およびSpdの値、前記血液中のWBC、RBC、Hb、Ht、葉酸、LDLC、Alb、プレアルブミン、CRP、TG、尿酸、γGTP、およびHbA1cの検査値、ならびに前記評価対象のBMI（Body　Mass　Index）および体重の値のうちの少なくとも１つの値、または、前記少なくとも１つの値が代入される変数を含む式および前記少なくとも１つの値を用いて算出された前記式の値を用いて、前記評価対象について認知症の将来の発症リスクを評価する評価手段
    　を備えること、
    　を特徴とする評価装置。     An evaluation device comprising a control unit,
    The control unit
    Concentration values of Ala, Arg, Asn, Cit, Gln, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, and Val in the blood to be evaluated, the blood 3h-Kyn, 5h-Indole-3-acetic acid, Anthranilic acid, Indol-3-acetic acid, Indole-3-lactic acid, Kynurenic acid, Picolinic acid, Quinolinic acid, Serotonin, Xanthurenic acid, Neopterin, 1- Values of Mehis, 3-Mehis, ADMA, b-AiBA, Cystathionine, GABA, hArg, Kyn, N6-acetyl-L-lysine, N8-acetyl-spd, SDMA, Thioproline, aABA, and Spd, WBC in said blood , RBC, Hb, Ht, folic acid, LDLC, Alb, prealbumin, CRP, TG, uric acid, γGTP, and HbA1c test values, and at least one of the BMI (Body Mass Index) and body weight values of the subject to be evaluated One value, or a formula containing a variable to which the at least one value is assigned and the value of the formula calculated using the at least one value, dementia for the subject to be evaluated. Having evaluation means for evaluation,
    An evaluation device characterized by:
  12. 　前記少なくとも１つの値または前記式の前記値を提供する端末装置とネットワークを介して通信可能に接続されており、
    　前記制御部は、
    　前記端末装置から送信された前記少なくとも１つの値または前記式の前記値を受信するデータ受信手段と、
    　前記評価手段で得られた評価結果を前記端末装置へ送信する結果送信手段と、
    　をさらに備え、
    　前記評価手段は、前記データ受信手段で受信した前記少なくとも１つの値または前記式の前記値を用いること、
    　を特徴とする請求項１１に記載の評価装置。     communicatively connected via a network to a terminal device that provides said at least one value or said value of said formula;
    The control unit
    data receiving means for receiving said at least one value or said value of said formula transmitted from said terminal device;
    result transmission means for transmitting the evaluation result obtained by the evaluation means to the terminal device;
    further comprising
    said evaluating means using said at least one value received at said data receiving means or said value of said formula;
    The evaluation device according to claim 11, characterized by:
  13. 　制御部を備える算出装置であって、
    　前記制御部は、
    　評価対象の血液中のAla、Arg、Asn、Cit、Gln、Gly、His、Ile、Leu、Lys、Met、Orn、Phe、Pro、Ser、Thr、Trp、Tyr、およびValの濃度値、前記血液中の3h-Kyn、5h-Indole-3-acetic　acid、Anthranilic　acid、Indol-3-acetic　acid、Indole-3-lactic　acid、Kynurenic　acid、Picolinic　acid、Quinolinic　acid、Serotonin、Xanthurenic　acid、Neopterin、1-Mehis、3-Mehis、ADMA、b-AiBA、Cystathionine、GABA、hArg、Kyn、N6-acetyl-L-lysine、N8-acetyl-spd、SDMA、Thioproline、aABA、およびSpdの値、前記血液中のWBC、RBC、Hb、Ht、葉酸、LDLC、Alb、プレアルブミン、CRP、TG、尿酸、γGTP、およびHbA1cの検査値、ならびに前記評価対象のBMI（Body　Mass　Index）および体重の値のうちの少なくとも１つの値、ならびに、前記少なくとも１つの値が代入される変数を含む認知症の将来の発症リスクを評価するための式を用いて、前記式の値を算出する算出手段を備えること、
    　を特徴とする算出装置。     A computing device comprising a control unit,
    The control unit
    Concentration values of Ala, Arg, Asn, Cit, Gln, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, and Val in the blood to be evaluated, the blood 3h-Kyn, 5h-Indole-3-acetic acid, Anthranilic acid, Indol-3-acetic acid, Indole-3-lactic acid, Kynurenic acid, Picolinic acid, Quinolinic acid, Serotonin, Xanthurenic acid, Neopterin, 1- Values of Mehis, 3-Mehis, ADMA, b-AiBA, Cystathionine, GABA, hArg, Kyn, N6-acetyl-L-lysine, N8-acetyl-spd, SDMA, Thioproline, aABA, and Spd, WBC in said blood , RBC, Hb, Ht, folic acid, LDLC, Alb, prealbumin, CRP, TG, uric acid, γGTP, and HbA1c test values, and at least one of the BMI (Body Mass Index) and body weight values of the subject to be evaluated one value, and a formula for evaluating the risk of developing dementia in the future that includes a variable into which the at least one value is substituted, using a calculation means for calculating the value of the formula;
    A computing device characterized by:
  14. 　制御部を備える情報処理装置において実行させるための評価プログラムであって、
    　前記制御部において実行させるための、
    　評価対象の血液中のAla、Arg、Asn、Cit、Gln、Gly、His、Ile、Leu、Lys、Met、Orn、Phe、Pro、Ser、Thr、Trp、Tyr、およびValの濃度値、前記血液中の3h-Kyn、5h-Indole-3-acetic　acid、Anthranilic　acid、Indol-3-acetic　acid、Indole-3-lactic　acid、Kynurenic　acid、Picolinic　acid、Quinolinic　acid、Serotonin、Xanthurenic　acid、Neopterin、1-Mehis、3-Mehis、ADMA、b-AiBA、Cystathionine、GABA、hArg、Kyn、N6-acetyl-L-lysine、N8-acetyl-spd、SDMA、Thioproline、aABA、およびSpdの値、前記血液中のWBC、RBC、Hb、Ht、葉酸、LDLC、Alb、プレアルブミン、CRP、TG、尿酸、γGTP、およびHbA1cの検査値、ならびに前記評価対象のBMI（Body　Mass　Index）および体重の値のうちの少なくとも１つの値、または、前記少なくとも１つの値が代入される変数を含む式および前記少なくとも１つの値を用いて算出された前記式の値を用いて、前記評価対象について認知症の将来の発症リスクを評価する評価ステップ
    　を含むこと、
    　を特徴とする評価プログラム。     An evaluation program to be executed in an information processing device comprising a control unit,
    for execution in the control unit,
    Concentration values of Ala, Arg, Asn, Cit, Gln, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, and Val in the blood to be evaluated, the blood 3h-Kyn, 5h-Indole-3-acetic acid, Anthranilic acid, Indol-3-acetic acid, Indole-3-lactic acid, Kynurenic acid, Picolinic acid, Quinolinic acid, Serotonin, Xanthurenic acid, Neopterin, 1- Values of Mehis, 3-Mehis, ADMA, b-AiBA, Cystathionine, GABA, hArg, Kyn, N6-acetyl-L-lysine, N8-acetyl-spd, SDMA, Thioproline, aABA, and Spd, WBC in said blood , RBC, Hb, Ht, folic acid, LDLC, Alb, prealbumin, CRP, TG, uric acid, γGTP, and HbA1c test values, and at least one of the BMI (Body Mass Index) and body weight values of the subject to be evaluated One value, or a formula containing a variable to which the at least one value is assigned and the value of the formula calculated using the at least one value, dementia for the subject to be evaluated. including an evaluation step to evaluate;
    A rating program characterized by:
  15. 　制御部を備える情報処理装置において実行させるための算出プログラムであって、
    　前記制御部において実行させるための、
    　評価対象の血液中のAla、Arg、Asn、Cit、Gln、Gly、His、Ile、Leu、Lys、Met、Orn、Phe、Pro、Ser、Thr、Trp、Tyr、およびValの濃度値、前記血液中の3h-Kyn、5h-Indole-3-acetic　acid、Anthranilic　acid、Indol-3-acetic　acid、Indole-3-lactic　acid、Kynurenic　acid、Picolinic　acid、Quinolinic　acid、Serotonin、Xanthurenic　acid、Neopterin、1-Mehis、3-Mehis、ADMA、b-AiBA、Cystathionine、GABA、hArg、Kyn、N6-acetyl-L-lysine、N8-acetyl-spd、SDMA、Thioproline、aABA、およびSpdの値、前記血液中のWBC、RBC、Hb、Ht、葉酸、LDLC、Alb、プレアルブミン、CRP、TG、尿酸、γGTP、およびHbA1cの検査値、ならびに前記評価対象のBMI（Body　Mass　Index）および体重の値のうちの少なくとも１つの値、ならびに、前記少なくとも１つの値が代入される変数を含む認知症の将来の発症リスクを評価するための式を用いて、前記式の値を算出する算出ステップ
    　を含むこと、
    　を特徴とする算出プログラム。     A calculation program to be executed in an information processing device comprising a control unit,
    for execution in the control unit,
    Concentration values of Ala, Arg, Asn, Cit, Gln, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, and Val in the blood to be evaluated, the blood 3h-Kyn, 5h-Indole-3-acetic acid, Anthranilic acid, Indol-3-acetic acid, Indole-3-lactic acid, Kynurenic acid, Picolinic acid, Quinolinic acid, Serotonin, Xanthurenic acid, Neopterin, 1- Values of Mehis, 3-Mehis, ADMA, b-AiBA, Cystathionine, GABA, hArg, Kyn, N6-acetyl-L-lysine, N8-acetyl-spd, SDMA, Thioproline, aABA, and Spd, WBC in said blood , RBC, Hb, Ht, folic acid, LDLC, Alb, prealbumin, CRP, TG, uric acid, γGTP, and HbA1c test values, and at least one of the BMI (Body Mass Index) and body weight values of the subject to be evaluated using a formula for assessing the risk of future development of dementia that includes one value and a variable into which said at least one value is substituted, and calculating the value of said formula;
    A calculation program characterized by:
  16. 　請求項１４または１５に記載のプログラムを記録したコンピュータ読み取り可能な記録媒体。 A computer-readable recording medium recording the program according to claim 14 or 15.
  17. 　制御部を備える評価装置と制御部を備える端末装置とをネットワークを介して通信可能に接続して構成される評価システムであって、
    　前記端末装置の前記制御部は、
    　評価対象の血液中のAla、Arg、Asn、Cit、Gln、Gly、His、Ile、Leu、Lys、Met、Orn、Phe、Pro、Ser、Thr、Trp、Tyr、およびValの濃度値、前記血液中の3h-Kyn、5h-Indole-3-acetic　acid、Anthranilic　acid、Indol-3-acetic　acid、Indole-3-lactic　acid、Kynurenic　acid、Picolinic　acid、Quinolinic　acid、Serotonin、Xanthurenic　acid、Neopterin、1-Mehis、3-Mehis、ADMA、b-AiBA、Cystathionine、GABA、hArg、Kyn、N6-acetyl-L-lysine、N8-acetyl-spd、SDMA、Thioproline、aABA、およびSpdの値、前記血液中のWBC、RBC、Hb、Ht、葉酸、LDLC、Alb、プレアルブミン、CRP、TG、尿酸、γGTP、およびHbA1cの検査値、ならびに前記評価対象のBMI（Body　Mass　Index）および体重の値のうちの少なくとも１つの値、または、前記少なくとも１つの値が代入される変数を含む式および前記少なくとも１つの値を用いて算出された前記式の値を前記評価装置へ送信するデータ送信手段と、
    　前記評価装置から送信された、前記評価対象についての認知症の将来の発症リスクに関する評価結果を受信する結果受信手段と、
    　を備え、
    　前記評価装置の前記制御部は、
    　前記端末装置から送信された前記少なくとも１つの値または前記式の前記値を受信するデータ受信手段と、
    　前記データ受信手段で受信した前記少なくとも１つの値または前記式の前記値を用いて、前記評価対象について認知症の将来の発症リスクを評価する評価手段と、
    　前記評価手段で得られた前記評価結果を前記端末装置へ送信する結果送信手段と、
    　を備えること、
    　を特徴とする評価システム。     An evaluation system configured by communicably connecting an evaluation device including a control unit and a terminal device including a control unit via a network,
    The control unit of the terminal device,
    Concentration values of Ala, Arg, Asn, Cit, Gln, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, and Val in the blood to be evaluated, the blood 3h-Kyn, 5h-Indole-3-acetic acid, Anthranilic acid, Indol-3-acetic acid, Indole-3-lactic acid, Kynurenic acid, Picolinic acid, Quinolinic acid, Serotonin, Xanthurenic acid, Neopterin, 1- Values of Mehis, 3-Mehis, ADMA, b-AiBA, Cystathionine, GABA, hArg, Kyn, N6-acetyl-L-lysine, N8-acetyl-spd, SDMA, Thioproline, aABA, and Spd, WBC in said blood , RBC, Hb, Ht, folic acid, LDLC, Alb, prealbumin, CRP, TG, uric acid, γGTP, and HbA1c test values, and at least one of the BMI (Body Mass Index) and body weight values of the subject to be evaluated a data transmission means for transmitting to the evaluation device an expression containing one value or a variable to which the at least one value is substituted and the value of the expression calculated using the at least one value;
    A result receiving means for receiving an evaluation result regarding the future risk of developing dementia for the evaluation target, which is transmitted from the evaluation device;
    with
    The control unit of the evaluation device,
    data receiving means for receiving said at least one value or said value of said formula transmitted from said terminal device;
    Evaluation means for evaluating the risk of future development of dementia for the evaluation object using the at least one value received by the data reception means or the value of the formula;
    result transmission means for transmitting the evaluation result obtained by the evaluation means to the terminal device;
    to provide
    A rating system characterized by:
  18. 　制御部を備えた端末装置であって、
    　前記制御部は、
    　評価対象についての認知症の将来の発症リスクに関する評価結果を取得する結果取得手段
    　を備え、
    　前記評価結果は、前記評価対象の血液中のAla、Arg、Asn、Cit、Gln、Gly、His、Ile、Leu、Lys、Met、Orn、Phe、Pro、Ser、Thr、Trp、Tyr、およびValの濃度値、前記血液中の3h-Kyn、5h-Indole-3-acetic　acid、Anthranilic　acid、Indol-3-acetic　acid、Indole-3-lactic　acid、Kynurenic　acid、Picolinic　acid、Quinolinic　acid、Serotonin、Xanthurenic　acid、Neopterin、1-Mehis、3-Mehis、ADMA、b-AiBA、Cystathionine、GABA、hArg、Kyn、N6-acetyl-L-lysine、N8-acetyl-spd、SDMA、Thioproline、aABA、およびSpdの値、前記血液中のWBC、RBC、Hb、Ht、葉酸、LDLC、Alb、プレアルブミン、CRP、TG、尿酸、γGTP、およびHbA1cの検査値、ならびに前記評価対象のBMI（Body　Mass　Index）および体重の値のうちの少なくとも１つの値、または、前記少なくとも１つの値が代入される変数を含む式および前記少なくとも１つの値を用いて算出された前記式の値を用いて、前記評価対象について認知症の将来の発症リスクを評価した結果であること、
    　を特徴とする端末装置。     A terminal device comprising a control unit,
    The control unit
    Equipped with a result acquisition means for acquiring an evaluation result regarding the future risk of developing dementia for an evaluation target,
    The evaluation results are Ala, Arg, Asn, Cit, Gln, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, and Val in the blood of the evaluation subject. concentration values of 3h-Kyn, 5h-Indole-3-acetic acid, Anthranilic acid, Indol-3-acetic acid, Indole-3-lactic acid, Kynurenic acid, Picolinic acid, Quinolinic acid, Serotonin, Xanthuric acid in the blood Acid, Neopterin, 1-Mehis, 3-Mehis, ADMA, b-AiBA, Cystathionine, GABA, hArg, Kyn, N6-acetyl-L-lysine, N8-acetyl-spd, SDMA, Thioproline, aABA, and Spd values , test values of WBC, RBC, Hb, Ht, folic acid, LDLC, Alb, prealbumin, CRP, TG, uric acid, γGTP, and HbA1c in the blood, and BMI (Body Mass Index) and body weight of the subject to be evaluated At least one value of the values, or using a formula containing a variable to which the at least one value is substituted and the value of the formula calculated using the at least one value, dementia for the evaluation subject that it is the result of evaluating the risk of future onset of
    A terminal device characterized by:
  19. 　前記評価対象について認知症の将来の発症リスクを評価する評価装置とネットワークを介して通信可能に接続されており、
    　前記制御部は、
    　前記少なくとも１つの値または前記式の前記値を前記評価装置へ送信するデータ送信手段
    　をさらに備え、
    　前記結果取得手段は、前記評価装置から送信された前記評価結果を受信すること、
    　を特徴とする請求項１８に記載の端末装置。     It is communicatively connected via a network with an evaluation device that evaluates the risk of future development of dementia for the evaluation object,
    The control unit
    data transmission means for transmitting said at least one value or said value of said formula to said evaluator;
    the result obtaining means receiving the evaluation result transmitted from the evaluation device;
    19. The terminal device according to claim 18, characterized by:
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