WO2022156388A1 - Structure de fixation et de retenue d'implant intravasculaire, système de pose et système d'endoprothèse à poignée - Google Patents

Structure de fixation et de retenue d'implant intravasculaire, système de pose et système d'endoprothèse à poignée Download PDF

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Publication number
WO2022156388A1
WO2022156388A1 PCT/CN2021/135628 CN2021135628W WO2022156388A1 WO 2022156388 A1 WO2022156388 A1 WO 2022156388A1 CN 2021135628 W CN2021135628 W CN 2021135628W WO 2022156388 A1 WO2022156388 A1 WO 2022156388A1
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WIPO (PCT)
Prior art keywords
intravascular implant
fixation
mandrel
delivery tube
delivery
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PCT/CN2021/135628
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English (en)
Chinese (zh)
Inventor
贾晶
张捷捷
吴重草
胡天宙
刘振全
孙冰
Original Assignee
江苏暖阳医疗器械有限公司
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Priority claimed from CN202110093968.3A external-priority patent/CN112716668A/zh
Priority claimed from CN202110094127.4A external-priority patent/CN112716666A/zh
Application filed by 江苏暖阳医疗器械有限公司 filed Critical 江苏暖阳医疗器械有限公司
Publication of WO2022156388A1 publication Critical patent/WO2022156388A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
    • A61F2/966—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
    • A61F2/97—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve the outer sleeve being splittable

Definitions

  • the present invention relates to medical instruments, and more particularly, to an intravascular implant fixation and retention structure, a delivery system and a handle-type stent system.
  • intravascular implants It is common for intravascular implants to be inaccurately positioned in the blood vessels during surgery and not placed in the position expected by the doctor. Therefore, it is hoped that the intravascular implant can be recovered into the delivery tube before the final release of the intravascular implant. Release again after adjusting the position.
  • intravascular implants either cannot be recovered, or recovery is difficult when the released intravascular implant length exceeds 50% of the total length of the intravascular implant; however, the intravascular implant is released to an extent that does not exceed 50%. There is no obvious effect for the doctor to judge whether it has reached the correct position. If the delivery system can achieve 90% release of the intravascular implant, it can still be recovered. At this time, the position of the intravascular implant has been basically determined, and the release can be better judged. whether succeed.
  • Patent CN108260342A describes a releasable delivery system comprising a delivery pusher consisting of an elongated member and an intravascular implant engagement mechanism on the distal portion of the elongated member and an intravascular implant with a proximal ring. Implants.
  • the release delivery system is mainly fixed by hooking the mesh structure at the tail of the intravascular implant. During the actual treatment push process, with the change of the clinical environment, the release delivery system may not be completely detached. Potential for failure to separate the delivery pusher from the intravascular implant with the proximal ring.
  • the system needs to be used in conjunction with an intravascular implant with a proximal ring and a delivery sheath, which has relatively high requirements on the intravascular implant; at the same time, the system requires the use of a delivery sheath with a specific inner diameter to avoid the use of The separation of the intravascular implant from the delivery pusher places high demands on the size of the delivery sheath.
  • the prior art intravascular implant delivery system usually needs to be used in conjunction with a microcatheter with a specific inner diameter, such as a microcatheter with an inner diameter of 0.027", which has certain limitations in application.
  • the present invention provides new improvements and multiple advantages in the field of delivery of intravascular implants: the delivery system of the present invention can achieve a release of blood vessels where the length of the intravascular implant exceeds 95% of the total length of the intravascular implant The implants are recovered multiple times, which is convenient for doctors to locate them more accurately during the operation.
  • the requirements for the structure of the intravascular implant are low, the release of the intravascular implant is simple and easy to operate, and the delivery system of the present invention has low requirements on the inner diameter of the microcatheter, and is suitable for various types of microcatheters. It is easy to use for surgical operation.
  • Intracranial aneurysm is a common cerebrovascular disease with high fatality and disability rate. It is generally believed that its formation is caused by abnormal local blood vessels leading to the formation of tumor-like protrusions under the impact of blood flow. The fatality rate of ruptured intracranial aneurysm is very high, almost as high as 50%.
  • the traditional treatment method is to use intracranial aneurysm clipping operation, but the operation is difficult, the operation risk is high, and it is greatly restricted by the doctor's experience and other factors; Compared with traditional treatment, interventional therapy has obvious advantages such as minimally invasive, safe and effective, and has been widely accepted and recognized by doctors and patients.
  • the blood flow diversion device is an emerging interventional treatment method for intracranial aneurysms in recent years. Its principle is to reconstruct the correct path of the blood vessels at the aneurysm and restore the direction of blood flow.
  • the blood flow diversion device reduces the blood entering the aneurysm by reshaping the blood flow direction of the intracranial blood vessels, so that the aneurysm gradually shrinks until it disappears.
  • the blood flow diversion device is generally used in conjunction with a self-expanding stent and a delivery device, and the self-expanding stent is delivered to the location of the intracranial aneurysm through a microcatheter and released.
  • the components are mechanically connected, but they are delivered to the target position through the friction between the delivery component and one end of the stent. Due to the small inner diameter of the microcatheter, this method results in a large force on one end of the stent during the pushing process, which is easy to be caused by uneven force.
  • the pushing process is squeezed and deformed, resulting in incomplete coverage of the lesion position after release, resulting in falling off or blockage, a certain risk of surgical failure, and even endangering the patient's life.
  • the present invention provides an intravascular implant fixing and holding structure.
  • a supporter fixed on a fixing mandrel realizes the fixing and holding of the intravascular implant and the delivery system. and separation.
  • the intravascular implant fixation and retention structure provided by the present invention includes a supporter which is fixed on the fixation mandrel and moves at the distal end of the delivery tube through the fixation mandrel.
  • the supporter and/or the delivery tube are matched in size to fix and retain the tail of the intravascular implant, and the fixation A mandrel performs the advancement of the intravascular implant.
  • the intravascular implant can pass through the fixing mandrel Recovery into the delivery tube and re-release, this ratio does not exceed 0.98. Beyond this ratio range, the intravascular implant is dislodged from the delivery tube, enabling release.
  • the present invention provides an intravascular implant delivery system including the above-mentioned intravascular implant fixation and retention structure.
  • the delivery system is composed of a delivery tube, a fixation mandrel and a holder fixed on the fixation mandrel.
  • Supporters can be one or more.
  • the present invention provides an intravascular implant fixation and retention structure, wherein the supporter is at least partially disposed inside the distal end of the delivery tube.
  • the invention provides an intravascular implant fixation and retention structure, wherein the connection between the supporter and the fixation mandrel is point connection, line connection or surface connection.
  • the present invention provides an intravascular implant fixing and holding structure, wherein the tail of the intravascular implant and the outgoing supporter are in point contact, line contact or surface contact.
  • the present invention provides an intravascular implant fixation and retention structure.
  • the cross-section of the connection between the supporter and the fixation mandrel along the extension direction of the fixation mandrel is shown as a continuous or discontinuous combination of multiple segments.
  • the holder is a rigid structure.
  • At least part of the structure of the supporter is deformed after being subjected to force.
  • the present invention provides an intravascular implant fixation and retention structure, wherein the ratio of the area of the connection between the supporter and the fixation mandrel to the projected area of the supporter on the surface of the fixation mandrel is (0.01-1):1.
  • the present invention provides an intravascular implant fixation and retention structure, and the length of the support along the extension direction of the fixation mandrel ranges from 0.1 mm to 1000 mm.
  • the invention provides an intravascular implant fixing and holding structure, wherein the ratio of the axial overlapping length of the supporter and the delivery tube to the axial extension length of the supporter is (0.001-1):1.
  • the present invention provides an intravascular implant fixation and retention structure, the supporter is pre-formed and connected to the fixation mandrel by bonding, welding or mechanical connection; the pre-forming method includes curing, winding, weaving, cutting , one or more of etching, injection molding, casting, forging, stamping, welding, machining, assembly, extrusion, etc.
  • the present invention provides an intravascular implant delivery system.
  • the intravascular implant delivery system is provided with a radiopaque material to identify the position of a developing element, including but not limited to gold, platinum-tungsten alloy and platinum-iridium alloy. or developing polymers.
  • the delivery system of the present invention can realize multiple recovery of the intravascular implant when the length of the released intravascular implant exceeds 95% of the total length of the intravascular implant, which is convenient for doctors to locate more accurately during the operation.
  • the delivery system of the present invention has low requirements on the structure of the intravascular implant.
  • Prior art release delivery systems require a mesh or loop structure to hook the tail of the intravascular implant, and therefore need to be used in conjunction with intravascular implants and delivery sheaths with proximal loops, arm members or marker coils, etc. .
  • only pressure and friction can be used between the intravascular implant and the delivery system to achieve fixation, retention and relative position change. It is fixed and maintained without other hooks, so the intravascular implant does not need a special tail structure, and is suitable for a variety of intravascular implants including dense mesh stents, occluders, and coils.
  • the delivery system of the present invention is simple and easy to operate to release the intravascular implant, and the fixation, retention and relative position change are realized by the relative movement of the fixed mandrel and the delivery tube, without introducing additional devices, channels, thermal drive or electrical
  • the driven pusher can be directly operated manually; but at the same time, it can also be used in conjunction with the corresponding push auxiliary tool, which has high flexibility.
  • the delivery system of the present invention has low requirements on the inner diameter of the microcatheter, and the inner diameter of the microcatheter can be used if the inner diameter of the microcatheter is larger than the outer diameter of the delivery tube, which is convenient for doctors to choose a model suitable for surgical operations.
  • Another object of the present invention is to provide a handle-type stent system, so as to solve the problem of uneven force and large resistance of the stent during the delivery process caused by dragging the stent to the target position by the friction component on the delivery system of the traditional blood flow guide stent. , the stent is prone to deformation and falling off.
  • a handle-type bracket system comprising: a release handle, the release handle includes: a handle body and a release switch arranged thereon; a handle connected to the release handle
  • a delivery system comprising: a delivery tube and a fixed mandrel extending therethrough, the delivery tube is connected to the handle body, the proximal end of the fixed mandrel is connected to the release switch, the fixed core
  • the shaft moves relative to the delivery tube under the action of the release switch; and the intravascular implant clamped by the delivery system, the proximal end of the intravascular implant has a protruding fixing portion of the above invention, The fixing portion is clamped by the above-mentioned intravascular implant fixing and holding structure formed by the distal end of the fixing mandrel and the delivery tube.
  • the release switch includes two states: “on” and “off”, when in the “off” state, the distal end of the delivery tube and the fixing mandrel are implanted in the blood vessel The two sides of the fixation part of the implant form a closed structure to fix it; when in the "open” state, the fixation mandrel is displaced relative to the delivery tube to release the intravascular implant.
  • the proximal end of the fixing mandrel is welded, bonded or mechanically connected to the release switch.
  • the distal end of the delivery tube has a stepped structure extending radially inward from the inner wall
  • the distal end of the fixed mandrel has a disc structure extending radially outward from the axis , the step structure and the disc structure form the intravascular implant fixing and retaining structure to clamp the fixing part of the intravascular implant between them.
  • the distal plane of the stepped structure is in contact with the proximal plane of the fixation portion, and the proximal plane of the disc structure is in contact with the distal plane of the fixation portion.
  • the fixing mandrel provided according to the present invention is a wire or rod-shaped structure with certain flexibility, except that the distal end is enlarged to form a disc-shaped structure, which can be made of metal, alloy or polymer material; the switch is pushed forward or withdrawn to release the switch.
  • the fixed mandrel can move forward or backward in linkage with it, the relative position of the fixed mandrel and the delivery tube is changed to realize the clamping and releasing of the intravascular implant.
  • the intravascular implant includes a keel bracket and a dense mesh bracket, which are connected by a structural sleeve with the keel bracket outside and the dense mesh bracket included, and are fixed by laser welding, adhesion and mechanical connection.
  • the inner diameter of the keel bracket is slightly larger than the outer diameter of the dense mesh bracket.
  • the wire diameter of the keel support is larger than the wire diameter of the dense mesh support, and the mesh size of the keel support is larger than the mesh size of the dense mesh support.
  • the wire diameter of the keel bracket is 0.01 mm to 1 mm, and the metal coverage is 1% to 50%; the wire diameter of the dense mesh bracket is 0.01 to 0.8 mm, and the metal coverage is 10%. %-60%.
  • the keel bracket and the dense mesh bracket are made of the same or different alloys with memory function, or metals with high elasticity, or polymer materials with high elasticity, and the alloys and metals include: stainless steel, platinum, platinum-tungsten Alloy, platinum-iridium alloy, nickel-titanium alloy or cobalt-chromium alloy; the polymer materials include: polyethylene, polyoxymethylene, polyurethane, polyester, polytetrafluoroethylene, fluorinated ethylene propylene copolymer, polyamide, polyimide Amine or Nylon.
  • the fixed part of the intravascular implant is a structure formed by knitting or cutting wires of the keel bracket; the two ends of the keel bracket are trumpet-shaped structures that protrude and extend beyond the dense mesh bracket, which is helpful for Improved anchoring performance of the stent to prevent displacement or shortening.
  • the distal end of the intravascular implant is also provided with a fixing portion formed by folded braided wires or cutting wires.
  • Both the proximal and distal fixing parts of the stent serve to constrict the braided wire or cutting wire at the port of the keel stent, and the proximal fixing part can also play the role of cooperating with the delivery system to fix the stent on the system.
  • the intravascular implant includes a developing element made of radiopaque material, and the radiopaque material includes: gold, platinum-tungsten alloy, platinum-iridium alloy or developing polymer material; the imaging element is woven into The developing wire in the bracket, or the point-shaped element fixed on the network node of the bracket, or the block-shaped element installed on the fixed part at the end of the bracket.
  • the grip handle is coated with a friction-increasing coating such as silica gel, which is convenient for the doctor to carry out the delivery operation.
  • a friction-increasing coating such as silica gel
  • both the delivery tube and the fixation mandrel have varying compliances that gradually increase from the proximal end to the distal end.
  • the self-expanding effect of the intravascular implant is reflected in: when the stent is delivered through the delivery system, the stent is bound in the microcatheter in a crimped state, and the head end is held by the stent Release the handle to hold; as long as the stent is released before the stent is released, whether the stent is pushed or retracted by the release handle, the stent remains in a crimped state, and the outer diameter of the stent in the crimped state is equal to the inner diameter of the microcatheter.
  • the stent After being pushed out of the microcatheter directly, the radial compression force provided by the inner wall of the microcatheter disappears, the stent can automatically expand, and its outer diameter is adapted to the vessel wall. During this process, the crimping and self-expansion of the keel scaffold and the dense mesh scaffold occur simultaneously. The flared structure on both sides of the keel bracket brings further anchoring effect to the bracket.
  • a handle-type bracket system provided by the present invention, its structural improvement and advantages over the prior art mainly include the following aspects:
  • the stent can be better matched with the handle-type delivery system, and the contact between the outer keel stent of the double-layer intravascular implant and the microcatheter Compared with the contact area between the single-layer dense mesh stent and the microcatheter, the area is reduced, which further reduces the pushing resistance.
  • the present invention provides a handle type that reduces the pushing resistance, ensures that the stent can be completely recovered and re-implanted during the implantation process, improves the fault tolerance rate, and reduces the operation difficulty of the dense mesh stent implantation. bracket system.
  • FIG. 1 is a schematic diagram of the longitudinal cross-sectional structure of the intravascular implant delivery system when it is in the delivery configuration.
  • FIG. 2 is a corresponding relationship between the length of the intravascular implant extending from the distal end of the delivery tube and the length of the intravascular implant.
  • Figure 4-10 Several shapes of the holder and the combination with the fixed mandrel.
  • Fig. 17 The relative position of the system at the initial stage of delivery in the delivery configuration during the action of the intravascular implant fixation and retention structure and the intravascular implant.
  • Fig. 18 The relative position of the system in the delivery configuration in the later stage of delivery during the interaction between the intravascular implant fixation and retention structure and the intravascular implant.
  • Fig. 19 The relative position of the system in the release configuration during the action of the intravascular implant fixation and retention structure and the intravascular implant.
  • Fig. 20 is a schematic diagram of the overall structure of the handle-type bracket system provided according to a preferred embodiment of the present invention in a clamped state.
  • FIG. 21 is a detailed enlarged view of the handle-type stand system shown in FIG. 20 in a clamped state.
  • FIG. 22 is an overall structural view of the handle-type stent system shown in FIG. 20 in a released state.
  • 23 and 24 are respectively schematic structural diagrams of sleeves according to two preferred embodiments of the present invention.
  • FIG. 25 is a schematic structural diagram of an intravascular implant according to a preferred embodiment of the present invention.
  • FIG. 26 is a schematic structural diagram of a keel bracket according to a preferred embodiment of the present invention.
  • 1-release handle 101-handle body, 102-release switch, 2-delivery system, 201-delivery tube, 201a-convex step mechanism, 202-fixed mandrel, 202a-disc structure, 3-intravascular Implant, 301-keel support, 302-dense mesh support, 303-proximal fixation part, 304-distal fixation part.
  • the terms “installed”, “connected”, “connected” and “fixed” should be understood in a broad sense, for example, it may be a fixed connection or a detachable connection , or integrated; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, and it can be the internal connection of the two elements or the interaction relationship between the two elements.
  • installed should be understood in a broad sense, for example, it may be a fixed connection or a detachable connection , or integrated; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, and it can be the internal connection of the two elements or the interaction relationship between the two elements.
  • the delivery systems of the present specification can be used to deliver various intravascular implants, such as various dense mesh stents, occluders, coils, or other implants.
  • various intravascular implants such as various dense mesh stents, occluders, coils, or other implants.
  • a schematic diagram of a dense mesh bracket is used in the accompanying drawings for illustration.
  • the delivery tube of the present specification is a lumen structure containing a circular, oval or polygonal inner lumen, and the term "delivery tube” is used throughout the specification for convenience.
  • microcatheter in this specification is a medical device that cooperates with the delivery system to complete the delivery, retraction, and release of the intravascular implant during the surgical process, such as various sizes of microcatheters, guiding catheters, intermediate catheters, Access catheters, delivery sheaths.
  • microcatheter is used throughout the specification for convenience.
  • the process of separating the intravascular implant from the delivery system is described by the word "release”. After the intravascular implant is partially detached from the microcatheter, it can still be recovered to the microcatheter through the delivery system. The process is described with the word “drawback”. The endovascular implant maintains a fixed and holding action with the delivery system before being released, and can be withdrawn one or more times.
  • orientation or positional relationship indicated by the orientation words such as "proximal end, distal end, front, rear” etc. is usually based on the orientation or positional relationship shown in the accompanying drawings, only for the purpose of For the convenience of describing the present application and simplifying the description, in the absence of the contrary, these directional words do not indicate or imply that the referred device or element must have a particular orientation or be constructed and operated in a particular orientation, and therefore should not be construed as a Limitation of the scope of protection of the application; the orientation words “inside and outside” refer to the inside and outside relative to the outline of each component itself.
  • orientations indicated by the orientation words such as “front, rear, top, bottom, left, right", “horizontal, vertical, vertical, horizontal” and “top, bottom” etc.
  • positional relationship is usually based on the orientation or positional relationship shown in the drawings, which is only for the convenience of describing the present application and simplifying the description, and these orientations do not indicate or imply the indicated device or element unless otherwise stated. It must have a specific orientation or be constructed and operated in a specific orientation, so it cannot be construed as a limitation on the protection scope of the application; the orientation words “inside and outside” refer to the inside and outside relative to the contour of each component itself.
  • spatially relative terms such as “on”, “over”, “on the surface”, “above”, etc., may be used herein to describe what is shown in the figures.
  • spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as “above” or “over” other devices or features would then be oriented “below” or “over” the other devices or features under other devices or constructions”.
  • the exemplary term “above” can encompass both an orientation of "above” and “below.”
  • the device may also be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptions used herein interpreted accordingly.
  • delivery configuration the configuration of the intravascular implant before release is collectively referred to as "delivery configuration”.
  • intravascular implants usually have a certain elasticity, their natural state and the crimping state under different external forces have different actual lengths.
  • the length of the intravascular implant when referring to the length of the intravascular implant, it refers to the length when it is completely in the delivery tube; when referring to the length of the intravascular implant extending from the distal end of the delivery tube, it corresponds to The exact same length of an intravascular implant in the delivery tube.
  • the present invention provides an intravascular implant fixation and retention structure, and an intravascular implant delivery system including the intravascular implant fixation and retention structure.
  • the intravascular implant delivery system includes a delivery tube 1 and a fixing mandrel 2 for fixing, holding and separating the intravascular implant 3 .
  • the intravascular implant fixation and retention structure includes a supporter 201, the supporter 201 is fixed on the fixation mandrel 2, all or part of the supporter 201 is located in the lumen of the delivery tube 1, and can be inside the lumen of the delivery tube 1 along with the fixation mandrel 2 Exercise.
  • the stationary mandrel 2 may also be referred to as a stationary mandrel.
  • the action of the intravascular implant is realized by the relative positional relationship between its tail, the holder and the delivery tube.
  • the tail of the endovascular implant is clamped by the supporter and the delivery tube, and the size and position of the three are matched to achieve the fixation and retention of the endovascular implant;
  • the push of the implant changes the relative position of the three and performs the separation action.
  • there is pressure, friction or other interaction force between the endovascular implant and the supporter and/or the inner wall of the delivery tube which is the force for fixing, maintaining and changing the relative position between the three.
  • the interaction force between the intravascular implant and the supporter and/or the inner wall of the delivery tube disappears, and the fixation effect between the three disappears, and the intravascular implantation
  • the material is separated from the delivery pipe.
  • the supporter 201 is completely externally arranged in the lumen of the delivery tube 1, the intravascular implant 3 is sleeved on the supporter 201, and the tail of the intravascular implant 3 can be inserted into the tube according to actual needs.
  • the lumen of delivery tube 1 In the lumen of delivery tube 1:
  • the intravascular implant 3 and the holder 201 are fixed by size matching;
  • the intravascular implant 3 When the tail of the intravascular implant 3 protrudes into the lumen of the delivery tube 1, the intravascular implant 3, the holder 201, and the delivery tube 1 are fixed by size matching.
  • the intravascular implant when the length of the intravascular implant extending beyond the distal end of the delivery tube does not exceed a certain value, the intravascular implant can be recovered into the delivery tube through the fixing mandrel.
  • the length of the endovascular implant is L.
  • the endovascular implant protrudes from the distal end of the delivery tube to a length of not more than 0.98L when the endovascular implant protrudes from the distal end of the delivery tube to a length of not more than 0.98L, the endovascular implant can be recovered through the fixed mandrel, and when the blood vessel is extended.
  • the length of the endovascular implant protruding from the distal end of the delivery tube is greater than 0.98L, the tail of the endovascular implant and the support and/or the inner wall of the delivery tube lose the fixation effect, and the intravascular implant is separated from the support and/or the delivery tube .
  • the length distribution falling within the interval can realize the retraction action of the intravascular implant.
  • the maximum ratio of the length of the endovascular implant extending from the distal end of the delivery tube to the length of the endovascular implant increased with the increase of the length of the endovascular implant.
  • the endovascular implant has a short overall length, the corresponding maximum ratio is relatively small, and when the endovascular implant has a longer overall length, a higher maximum ratio can be achieved.
  • the length of the intravascular implant that can be recovered from the distal end of the delivery tube does not exceed 0.8L; when the total length of the intravascular implant exceeds 100mm, the recovery can be achieved.
  • the length of the endovascular implant extending beyond the distal end of the delivery tube can reach 0.98L.
  • the length of the intravascular implant extending from the distal end of the delivery tube is 0.8L-0.95L, which is a suitable release state.
  • the ratio of the maximum diameter of the cross-section of the holder in the direction perpendicular to the fixed mandrel in the natural non-crimping state to the inner diameter of the delivery pipe head is (0.1-10.0):1.
  • the holder, the fixation mandrel and the intravascular implant all have a certain volume. When the size of the delivery tube is small, the ratio of the holder, the fixation mandrel and the intravascular implant to the inner diameter of the head of the delivery tube is larger.
  • the preferred length combination is represented by an array (A', B'), wherein A' represents the inner diameter of the head of the delivery pipe, B' represents the maximum outer diameter of the holder, and the unit of length is millimeters (mm) .
  • the ratio of the maximum cross-sectional dimension of the holder in the direction perpendicular to the fixed mandrel in the natural non-crimping state to the inner diameter of the delivery tube is (0.01-2): 1 .
  • Preferred length combinations include (0.26, 0.33), (0.27, 0.21).
  • the ratio of the maximum cross-sectional dimension of the holder in the direction perpendicular to the fixed mandrel in the natural non-crimping state to the inner diameter of the delivery tube is (0.1-5): 1 .
  • Preferred length combinations include (0.36, 0.53), (0.36, 0.6), (0.36, 0.77), (0.4, 0.37), (0.4, 0.44), (0.4, 0.58), (0.4, 0.66), (0.4, 0.83), (0.49, 0.42), (0.52, 0.41), (0.52, 0.44), (0.55, 0.53), (0.55, 0.78), (0.55, 0.88).
  • the ratio of the maximum cross-sectional dimension of the holder in the direction perpendicular to the fixed mandrel in the natural non-crimping state to the inner diameter of the delivery tube is (0.2-10): 1 .
  • Preferred length combinations include (0.61, 0.77), (0.62, 0.45), (0.7, 0.5), (0.7, 0.88), (0.7, 0.93), (0.8, 1.28), (0.82, 1.43), (1, 0.99).
  • the ratio of the maximum cross-sectional dimension of the holder in the direction perpendicular to the fixed mandrel in the natural non-crimping state to the inner diameter of the delivery tube is (0.5-10):1.
  • Preferred length combinations include (1.2, 1.53), (1.2, 1.6), (1.5, 1.8) (1.6, 1.99).
  • an intravascular implant fixation and retention structure provided according to the present invention, several shapes of the supporter and the combination with the fixation mandrel are shown.
  • On a single fixed mandrel one or more radially extending protruding holders are usually fixed.
  • the connection between the holder and the fixed mandrel can be point connection, line connection or surface connection.
  • connection between the fixed mandrel and the holder is point connection or line connection
  • a plurality of radially extending holders are fixed on a single fixed mandrel; when the connection between the fixed mandrel and the holder is In the case of surface connection, one or more radially extending holders are fixed on a single fixed mandrel.
  • the cross-section of the connection between the holder and the fixed mandrel in the extending direction perpendicular to the fixed mandrel shows a continuous or discontinuous combination of multiple sections.
  • the length of the holder along the extending direction of the fixed mandrel is in the range of 0.1 mm to 1000 mm.
  • the holder is integrally formed with the stationary mandrel.
  • the supporter is pre-formed and connected to the fixed mandrel by bonding or welding or mechanical connection; One or more of welding, machining, assembly, extrusion, etc.
  • the support is displayed as an outer contour of a cylinder, a polygon or a combination of simple geometric figures.
  • a supporter which is shown as an outer contour formed by splicing a circular truncated cone and a cylinder, is fixed on the fixed mandrel.
  • the holder is a rigid structure and is integrally formed with the fixed mandrel.
  • the ratio of the maximum cross-sectional dimension of the holder in the direction perpendicular to the fixed mandrel to the inner diameter of the delivery tube is 0.8, and in the delivery configuration, the holder is completely within the lumen of the delivery tube.
  • a supporter which is shown as an outer contour formed by splicing a circular truncated cone and a cylinder, is fixed on the fixed mandrel. At least part of the structure of the supporter is deformed after being subjected to force, and the supporter is connected to the fixed mandrel by bonding after being preformed.
  • the ratio of the maximum cross-sectional dimension of the holder in the direction perpendicular to the fixed mandrel to the inner diameter of the delivery tube is 1.5.
  • the outer diameter of the cylindrical portion of the holder is smaller than that of the delivery tube and is located in the lumen of the delivery tube.
  • the outer diameter of the round table part is larger than that of the delivery tube, and is located outside the lumen of the delivery tube.
  • a holder showing a smooth and streamlined outer profile is fixed on the fixed mandrel.
  • the holder is a rigid structure, which is connected to the fixed mandrel by bonding after pre-forming.
  • the ratio of the largest dimension of the cross section of the holder in the direction perpendicular to the fixed mandrel to the inner diameter of the delivery tube is 0.92, and the holder is completely within the lumen of the delivery tube in the delivery configuration.
  • a supporter connected to the surface of the fixed mandrel is formed by winding wires on the fixed mandrel.
  • the ratio of the maximum cross-sectional dimension of the holder in the direction perpendicular to the fixed mandrel to the inner diameter of the delivery tube is 0.56, and the holder is completely within the delivery tube lumen in the delivery configuration.
  • the holder fixed on the fixing mandrel is shown as a mesh woven structure.
  • the supporter is a rigid wire material that is woven into a cross-network structure to obtain a certain elasticity, and then connected to the fixed mandrel by bonding.
  • the holder has a variable maximum outer diameter, and in the delivery configuration, the holder is completely within the lumen of the delivery tube, and the ratio of the maximum cross-sectional dimension in the direction perpendicular to the fixed mandrel to the inner diameter of the delivery tube is 1 .
  • the holder fixed on the fixed mandrel is shown as a plurality of radially extending small uprights.
  • the holder is a rigid structure, which is preformed and connected to the fixed mandrel by welding.
  • the ratio of the maximum cross-sectional dimension of the holder in the direction perpendicular to the fixed mandrel to the inner diameter of the delivery tube is 0.9, and the holder is completely within the delivery tube lumen in the delivery configuration.
  • the holder fixed on the fixed mandrel is shown as a plurality of rigid structures connected with the fixed mandrel through a filamentary connection structure.
  • the holder is a combination of rigid structure and flexible structure, and is connected to the fixed mandrel by welding after pre-forming.
  • the holder has a variable maximum outer diameter, the holder is completely within the lumen of the delivery tube in the delivery configuration, and the ratio of the maximum cross-sectional dimension of the holder in the direction perpendicular to the fixed mandrel to the inner diameter of the delivery tube is 3.
  • the ratio of the axially overlapping length of the holder and the intravascular implant to the axially extending length of the holder is (0.001-1):1.
  • the axial overlap length of the holder with the intravascular implant covers as much of the holder as possible.
  • the ratio of the axially overlapping length of the holder and the delivery tube to the axially extending length of the holder is (0.001-1):1.
  • the axial overlap length of the holder with the delivery tube covers as much of the holder as possible.
  • the maximum outer diameter of the holder portion is greater than the inner diameter of the delivery tube, the holder may not be completely covered by the delivery tube.
  • the ratio of the area of the connection between the supporter and the fixed mandrel to the projected area of the supporter on the surface of the fixed mandrel is (0.01-1):1.
  • the projected area of the holder on the surface of the fixed mandrel is determined by its outer contour.
  • the supporter supports the inner wall of the intravascular implant with an outer contour, so that part or all of the outer side of the intravascular implant adheres to the inner wall of the delivery tube.
  • the supporter protrudes from the mesh or other surface through holes of the intravascular implant, and the outer contour of the supporter is attached to the inner wall of the delivery tube.
  • the support material is one or more rigid inelastic materials.
  • the supporter is made of one or more soft elastic materials.
  • the supporter is a structure with certain elasticity formed by one or more hard inelastic materials or soft elastic materials after weaving, winding and other forming processes.
  • 11-16 it is a kind of intravascular implant fixation and holding structure provided according to the present invention, the supporter is in the delivery configuration of several outer contour shapes, and its connection with the delivery tube and the vascular implantation.
  • the positional relationship of the incoming objects. 11-16 are schematic cross-sectional views at A-A in FIG. 1 .
  • the supporter is a hard inelastic material
  • the cross-section is shown as a circle
  • the outer contour supports the inner wall of the intravascular implant, so that the intravascular implant is Part or all of the outer side is attached to the inner wall of the delivery tube.
  • the ratio of the area of the connection between the holder and the fixed mandrel to the projected area of the holder on the surface of the fixed mandrel is 1.
  • the supporter is a hard inelastic material, and the cross-section is shown as a polygon, and the outer contour supports the inner wall of the intravascular implant, so that the outside of the intravascular implant Part or all of it is attached to the inner wall of the delivery pipe.
  • the ratio of the area of the connection between the holder and the fixed mandrel to the projected area of the holder on the surface of the fixed mandrel is 1.
  • the supporter is a hard inelastic material, and the cross-section is shown as a combination of simple geometric shapes. Part or all of the outer side of the implant is attached to the inner wall of the delivery tube. The ratio of the area of the connection between the holder and the fixed mandrel to the projected area of the holder on the surface of the fixed mandrel is 1.
  • the supporter is a hard inelastic material, and the cross-section is shown as a combination of simple geometric shapes. Part or all of the outer side of the implant is attached to the inner wall of the delivery tube. The ratio of the area of the connection between the holder and the fixed mandrel to the projected area of the holder on the surface of the fixed mandrel is 0.45.
  • the supporter is a soft elastic material, and in the delivery configuration, the supporter structure can be deformed by force, showing an irregular shape.
  • the supporter protrudes from the mesh or other surface through holes of the intravascular implant, and the outer contour of the supporter is attached to the inner wall of the delivery tube.
  • the ratio of the area of the connection between the holder and the fixed mandrel to the projected area of the holder on the surface of the fixed mandrel is 1.
  • the supporter is a soft elastic material, and in the delivery configuration, the supporter structure can be deformed by force, showing an irregular shape.
  • the supporter protrudes from the mesh or other surface through holes of the intravascular implant, and the outer contour of the supporter is attached to the inner wall of the delivery tube.
  • the ratio of the area of the connection between the holder and the fixed mandrel to the projected area of the holder on the surface of the fixed mandrel was 0.88.
  • the material of the supporter is one or more of metals, alloys or polymer materials; metals or alloys include but are not limited to stainless steel, platinum, platinum-tungsten alloy, platinum-iridium alloy, nickel-titanium alloy or cobalt-chromium alloy; Polymeric materials include, but are not limited to, polyethylene, polyoxymethylene, polyurethane, polyester, polytetrafluoroethylene, fluorinated ethylene propylene copolymer, polyamide, polyimide, or nylon.
  • the present invention provides an intravascular implant delivery system.
  • the intravascular implant delivery system includes a delivery tube and a fixed mandrel.
  • the delivery tube is an integrally formed structure.
  • the delivery tube is a non-integrated structure, which is a structure with an internal lumen formed by one or more of cutting, assembling, and braiding.
  • a hypotube can be used as the delivery tube in the present invention.
  • the hypotube can be made of metal or polymer material.
  • Polymer material can be stainless steel, platinum, platinum-tungsten alloy, platinum-iridium alloy, nickel-titanium alloy or cobalt-chromium alloy, and the polymer material includes but is not limited to polyethylene, polyoxymethylene, polyurethane, polyester, poly Tetrafluoroethylene, fluorinated ethylene propylene copolymer, polyamide, polyimide or nylon.
  • the fixed mandrel has a developing element 202 made of radiopaque material to identify the position of the element, and the material includes: gold, platinum-tungsten alloy, platinum-iridium alloy or developing polymer.
  • the operator can observe the real-time position of the device through the imaging element, so as to determine whether the intravascular implant is in the correct position.
  • the fixing mandrel and the delivery tube are kept relatively fixed, and the supporter is located in the head of the delivery tube and fixes the intravascular implant.
  • the outer contour provides pressure to make the intravascular implant close to the inner wall of the delivery tube, enhances the friction force between the intravascular implant and the delivery tube, and prevents the intravascular implant from falling out during the pushing or retracting process.
  • the fixed mandrel and the delivery tube move relative to each other, and the supporter protrudes from the head of the delivery tube, and finally reaches the release configuration (Fig. 19) to realize the intravascular implant. release.
  • the intravascular implant delivery system is used in conjunction with a microcatheter for the delivery of the intravascular implant.
  • the delivery system secures the intravascular implant and delivers it along the microcatheter to the vicinity of the release point, and then withdraws the microcatheter and performs further repositioning through the delivery system until accurate positioning and release.
  • the selection of the microcatheter does not affect the pushing, retracting and releasing actions of the intravascular implant.
  • the intravascular implant can still be driven by the delivery system to adjust the position. Therefore, for the intravascular implant delivery system of the present invention, the range of the inner and outer diameters of the microcatheter used with it is not specifically limited, and more choices are available.
  • the intravascular implant delivery system needs to be administered in cooperation with a pushing structure, and the intravascular implant pushing structure is connected to the fixing mandrel, and the delivery tube, the fixing mandrel and the intravascular implant can be changed by pushing the fixing mandrel.
  • the relative position of the device can realize the push, retraction and release of the intravascular implant.
  • the relative positions of the delivery tube, the fixation mandrel and the intravascular implant do not change, and the intravascular implant will not be prolapsed whether in the delivery state or the retracted state, and the intravascular implant is released It can be repeatedly withdrawn and repositioned before, and finally the accurate release of the intravascular implant can be achieved, which greatly improves the success rate of the operation and achieves the best therapeutic effect.
  • pushing the fixed mandrel drives the relative position of the holder and the delivery tube to change, and the holder extends from the head of the delivery tube to release the intravascular implant.
  • the intravascular implant delivery system when the intravascular implant is in an unreleased state, the intravascular implant delivery system maintains the stability and flexibility that the system should have, and can pass existing Compared with the delivery device that uses the physical connection between the component and the intravascular implant for delivery, the present invention tightly fixes the intravascular implant and the delivery system through the supporter and the delivery tube, and does not It is easy to fall off, and it can also transmit the conveying force more effectively.
  • the intravascular implant delivery system can also realize precise positioning of the intravascular implant release, control the fixed mandrel to position the intravascular implant to the release position, and the intravascular implant can be accurately released after the microcatheter is withdrawn;
  • the intravascular implant position can still be adjusted before release, until the release position of the intravascular implant is determined to be accurate, which can ensure the maximum success rate.
  • a handle-type stent system is provided according to a preferred embodiment of the present invention, which is mainly composed of a release handle 1 , a delivery system 2 and an intravascular implant 3 .
  • the release handle 1 includes: a handle body 101 and a release switch 102 disposed thereon.
  • the release switch 102 has two states of "on” and “off” for controlling the release action of the intravascular implant 3 .
  • the delivery system 2 includes: a delivery tube 201 and a fixed mandrel 202 extending through the delivery tube 201 , the delivery tube 201 is connected to the handle body 101 , and the proximal end of the fixed mandrel 202 is connected to the release switch 102 , so as to realize the relative delivery of the fixed mandrel 202 Axial relative movement of the tube 201, the distal end of the fixation mandrel 202 and the delivery tube 201 form an intravascular implant fixation and retention structure for clamping the intravascular implant 3, which will be described in detail below.
  • the proximal end in this document refers to the direction close to the release handle 1
  • the distal end refers to the direction close to the intravascular implant 3 .
  • the distal end of the delivery tube 201 has a step structure 201a extending radially inward from the inner wall of the delivery tube, and the distal end of the fixed mandrel 202 has a radially outward extending from the shaft center.
  • the disc structure 202a, the step structure 201a and the disc structure 202a can form a fixation and retention structure for the intravascular implant. It should be understood that the largest radial dimension of the disc structure 202a is smaller than the inner diameter dimension of the conveying pipe 201 , so the disc structure 202a can freely enter and exit the conveying pipe 201 .
  • the proximal end of the intravascular implant 3 has fixing portions 303 that facilitate the clamping of the fixing and retaining structure of the intravascular implant, two of which are shown in FIG. 22 , but it should be understood that the fixing portions 303 are not only Limited to two, other numbers are possible.
  • the handle body 101 can be coated with a coating such as silica gel to increase the frictional force, so as to facilitate the delivery operation by the doctor.
  • a coating such as silica gel to increase the frictional force, so as to facilitate the delivery operation by the doctor.
  • the proximal end of the fixation mandrel 202 and the release switch 102 may be welded, glued or mechanically connected.
  • the delivery tube 201 is made of a non-uniform material, and the flexibility gradually increases from the proximal end to the distal end, and the better flexibility of the distal end is conducive to the advancement of the head of the delivery system 2 in the tortuous blood vessel , while the rigid proximal end provides the mechanical strength required for propulsion.
  • the material of the conveying pipe 201 can be metal, alloy or polymer; when the conveying pipe 201 is made of metal or alloy, it is preferably processed into a helical tubular shape with changing thread pitch so that its compliance can change along the axial direction, as shown in FIG. 23 .
  • the conveying pipe 201 is formed with a polymer material, it is preferable to use a non-uniform material, or to realize the difference in the compliance performance of different segments through the splicing and combination of different materials, as shown in FIG. 24 .
  • the intravascular implant 3 includes a keel bracket 301, a dense mesh bracket 302, and a fixing portion 303 at the proximal end of the keel bracket 301.
  • the distal end of the keel bracket 301 also The fixing portion 304 is included.
  • the keel support 301 and the dense mesh support 302 are prepared by braiding or cutting respectively.
  • the inner diameter of the keel bracket 301 is slightly larger than the outer diameter of the dense mesh bracket 302, and the two are connected by a structural sleeve with the keel bracket 301 outside and the dense mesh bracket 302 inside, through laser welding, adhesion, mechanical connection fixed in other ways.
  • the double-layer structure stent provided according to the present invention reduces the contact area between the intravascular implant and the microcatheter, and greatly reduces the pushing resistance of the stent.
  • outer keel support 301 is a sparse mesh structure with a larger wire diameter and a larger mesh
  • the inner dense mesh support 302 is a dense mesh structure with a smaller wire diameter and smaller mesh.
  • the fixing parts 303 and 304 at both ends of the bracket are fixing parts formed by the braided wires or cutting wires at the ends of the keel brackets, and can be welding spots formed by welding, or connecting parts or buttons formed by mechanical fixing.
  • the knot structure may also be a glue point formed by bonding, and its shape is not particularly limited.
  • the fixing part 303 at the proximal end of the intravascular implant 3 is clamped by the delivery tube 201 and the fixing mandrel 202, and the distal end is the free end.
  • the fixed portion 304 at the distal end is not connected.
  • the keel bracket 301 and the dense mesh bracket 302 can be made of the same or different memory alloys or metal or polymer materials with high elasticity
  • the metals or alloys include but are not limited to stainless steel, platinum, platinum-tungsten Alloy, platinum-iridium alloy, nickel-titanium alloy or cobalt-chromium alloy
  • polymer materials include but are not limited to polyethylene, polyoxymethylene, polyurethane, polyester, polytetrafluoroethylene, fluorinated ethylene propylene copolymer, polyamide, polyimide Amine or Nylon.
  • proximal fixing portion 303 and the distal fixing portion 304 may have the same structure or different structures, and when they are completely the same, the positions of the two may be interchanged, which does not limit the direction in which the stent is placed.
  • the intravascular implant 3 also preferably includes a developing element, which is made of radiopaque material, including but not limited to gold, platinum-tungsten alloy, platinum-iridium alloy or developing polymer material; the developing element can be woven into the material.
  • the developing wire in the bracket is fixed on the dot-shaped element on the bracket network, or is installed on the fixed parts at both ends of the bracket.
  • the two ends of the keel bracket 301 protrude and extend beyond the dense mesh bracket 302 and are formed into a horn-like structure to improve the anchoring performance of the bracket and prevent the bracket from being displaced or shortened during use.
  • handle-type bracket system can be operated and used under the existing technical means.
  • FIG. 21 which is a schematic structural diagram of the intravascular implant 3 in a clamped state
  • the distal end of the delivery tube 201 and the distal end of the fixed mandrel 202 are implanted in the blood vessel
  • a closed structure is formed on both sides of the fixing portion 303 of the object 3
  • the distal plane of the step structure 201a is in contact with the proximal plane of the fixing portion 303
  • the proximal plane of the disc structure 202a is in contact with the distal plane of the fixing portion 303
  • Push and pull the release handle 1 the stepped structure 201a of the delivery tube 201 conducts the forward pushing force
  • the disc structure 202a of the fixed mandrel 202 provides the retraction pulling force, so the intravascular implant 3 has a relatively high performance when advancing and retracting in the microcatheter. Small push resistance.
  • the release switch 102 when the release switch 102 is in the “off” configuration, the fixed portion 303 at the proximal end of the keel bracket is restricted from moving, the intravascular implant 3 will not be released, and the intravascular implant can be easily realized 3 complete recovery and reimplantation.
  • the stent needs to be used in conjunction with the microcatheter.
  • the microcatheter first builds a channel in the blood vessel, so that the system can be successfully delivered to the hemangioma.
  • the intravascular implant 3 In the initial stage of release, the intravascular implant 3 is always delivered in the microcatheter in a crimped state, until the aneurysm neck, where the intravascular implant 3 is released from the microcatheter and is in a state to be released.
  • FIG. 22 it is a schematic structural diagram of the intravascular implant 3 in the released state, that is, when the release switch 102 is in the “on” configuration, the fixing mandrel 202 is linked with the release switch 102, and the distal end of the delivery tube 201 and the The closed structure formed by the distal end of the fixing mandrel 202 on both sides of the fixing part 303 is loosened, that is, the fixing mandrel 202 no longer provides the supporting force required for the fixing of the fixing part 303 of the keel bracket, and the fixing part 303 at the proximal end of the keel bracket is disengaged, The intravascular implant 3 is released in the desired location.
  • a handle-type stent system is provided.
  • a keel stent with a larger hole diameter outside the dense mesh stent By designing a keel stent with a larger hole diameter outside the dense mesh stent, the contact area between the stent and the microcatheter is reduced, and the pushing resistance is reduced; the use of a delivery tube and a fixed core
  • the shaft cooperates with the push stent to reduce the loss of pushing force.
  • the stent release switch is closed, the stent is firmly held and will not come out, which ensures that the stent can be completely recovered and re-implanted during the implantation process, which increases the fault tolerance during the operation. It can effectively reduce the operation difficulty of single-layer dense mesh stent implantation.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
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Abstract

La présente invention concerne une structure de fixation et de retenue d'implant intravasculaire, un système de pose (2) et un système d'endoprothèse à poignée. La structure de fixation et de retenue d'implant intravasculaire comprend un support (201) fixé sur un mandrin fixe (2, 202) et se déplaçant à une extrémité distale d'un tube de distribution (1, 201) au moyen du mandrin fixe (2, 202). Pendant un processus de pose d'un implant intravasculaire (3), la fixation, la retenue et la séparation entre l'implant intravasculaire (3) et le système de pose (2) sont mises en œuvre au moyen du support (201) fixé sur le mandrin fixe (2, 202). Le système de pose d'implant intravasculaire présente une grande souplesse, un taux de réussite élevé et une fonction de rétraction et de libération à répétition, est apte à s'adapter à divers microcathéters, et est fabriqué à l'aide de la structure de fixation et de retenue d'implant intravasculaire. Le système d'endoprothèse à poignée réduit la résistance à la poussée, garantit qu'une endoprothèse peut être complètement récupérée et réimplantée au cours d'un processus d'implantation, améliore considérablement le taux de tolérance aux erreurs et réduit considérablement la difficulté opérationnelle de l'implantation d'une endoprothèse à maillage dense, et est obtenu à l'aide de la structure de fixation et de retenue d'implant intravasculaire.
PCT/CN2021/135628 2021-01-22 2021-12-06 Structure de fixation et de retenue d'implant intravasculaire, système de pose et système d'endoprothèse à poignée WO2022156388A1 (fr)

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CN202110093968.3A CN112716668A (zh) 2021-01-22 2021-01-22 一种血管内植入物固定保持结构和一种血管内植入物输送系统
CN202110094127.4 2021-01-22
CN202110093968.3 2021-01-22
CN202110094127.4A CN112716666A (zh) 2021-01-22 2021-01-22 一种手柄式支架系统

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CN110151368A (zh) * 2019-06-28 2019-08-23 微创神通医疗科技（上海）有限公司 血管植入物、输送装置及医疗设备
CN112716668A (zh) * 2021-01-22 2021-04-30 江苏暖阳医疗器械有限公司 一种血管内植入物固定保持结构和一种血管内植入物输送系统
CN112716667A (zh) * 2021-01-22 2021-04-30 江苏暖阳医疗器械有限公司 一种血管内植入物固定保持结构和一种血管内植入物输送系统
CN214967185U (zh) * 2021-01-22 2021-12-03 江苏暖阳医疗器械有限公司 一种血管内植入物固定保持结构和一种血管内植入物输送系统
CN215019796U (zh) * 2021-01-22 2021-12-07 江苏暖阳医疗器械有限公司 一种血管内植入物固定保持结构和一种血管内植入物输送系统

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115844604A (zh) * 2023-01-09 2023-03-28 江苏暖阳医疗器械有限公司 一种血流导向支架系统
CN117100456A (zh) * 2023-10-18 2023-11-24 北京华脉泰科医疗器械股份有限公司 血管支架及其输送器
CN117100456B (zh) * 2023-10-18 2024-02-02 北京华脉泰科医疗器械股份有限公司 血管支架及其输送器

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