WO2022110575A1 - 一种多反应杯连续测量的发光测量装置及发光测量方法 - Google Patents
一种多反应杯连续测量的发光测量装置及发光测量方法 Download PDFInfo
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- WO2022110575A1 WO2022110575A1 PCT/CN2021/081004 CN2021081004W WO2022110575A1 WO 2022110575 A1 WO2022110575 A1 WO 2022110575A1 CN 2021081004 W CN2021081004 W CN 2021081004W WO 2022110575 A1 WO2022110575 A1 WO 2022110575A1
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- cuvette
- needle
- liquid injection
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- measurement
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- 238000005259 measurement Methods 0.000 title claims abstract description 122
- 238000004020 luminiscence type Methods 0.000 title claims abstract description 81
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 48
- 238000000034 method Methods 0.000 title claims abstract description 10
- 239000007788 liquid Substances 0.000 claims abstract description 216
- 238000002347 injection Methods 0.000 claims abstract description 131
- 239000007924 injection Substances 0.000 claims abstract description 131
- 239000002699 waste material Substances 0.000 claims abstract description 24
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- 238000012360 testing method Methods 0.000 claims abstract description 10
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- 238000006073 displacement reaction Methods 0.000 claims description 11
- 238000000691 measurement method Methods 0.000 claims description 10
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
Definitions
- the application belongs to the technical field of medical devices, and in particular relates to a luminescence measurement device and a luminescence measurement method for continuous measurement of multiple reaction cups.
- the most commonly used diagnostic method in the medical field - in vitro diagnosis refers to the collection of human body fluids, excrement, secretions for chemical composition or chemical reaction analysis, so as to determine human diseases, such as chemiluminescence immunoassay, molecular diagnosis, etc.
- These diagnostic methods all use automatic or semi-automatic instruments to add samples, analyze, and give a diagnosis report.
- Such instruments have a functional unit—a luminescence value detection unit (ie, a luminescence measurement device).
- the luminescence measurement device is a key functional unit that affects the accuracy of the measurement results and the test speed of the chemiluminescence immunoanalyzer. It can measure a single cuvette. After the measurement, open the sealed compartment door and take out the cuvette, and then proceed to the next test. In this way, when one cuvette in the measuring room is measuring, the other cuvette stations are in a waiting state, which greatly reduces the instrument At the same time, after the luminescence measurement is completed, the waste liquid and the used cuvette are not treated separately, which greatly increases the cost and time of post-processing.
- the technical problem to be solved by the present invention is: in order to solve the technical problems of low test speed of the cuvette luminescence measurement device and luminescence measurement method in the prior art, and high post-processing cost of the cuvette after use, a multi-reactor cuvette is provided.
- a luminescence measurement device and luminescence measurement method for continuous measurement is provided.
- a luminescence measurement device for continuous measurement of multiple reaction cups comprising:
- the measuring chamber is provided with a measuring chamber cover plate with an opening at the top, a photon via hole is opened on the side, and an accommodating cavity for accommodating a turntable is provided inside the turntable.
- the cuvette is in the position of the cuvette, and the opening is used to put the cuvette into the cuvette or remove the cuvette from the cuvette;
- the drive unit is used to drive the turntable to rotate, so that the cuvette is successively circulated between the different stations of the cuvette pick and place position, shake evenly, liquid injection or luminescence measurement position, and liquid suction position;
- Door switch unit for opening or closing the opening on the cover of the measuring chamber
- the shaking unit is used to perform shaking action on the cuvette transferred to the shaking position;
- the luminescence measurement unit can close or open the photon via hole on the measurement chamber, and collect the luminescence amount of the substance in the cuvette on the liquid injection or luminescence measurement position when the photon via hole is opened;
- the liquid injection and liquid suction unit is used to inject liquid into the cuvette corresponding to the liquid injection level and extract the waste liquid from the cuvette corresponding to the liquid suction level, including the bracket fixed on the cover plate of the measuring chamber, the drive assembly, and the needle assembly
- the needle assembly includes a suction needle, a liquid injection needle, and a needle fixing plate on the upper part of the cover plate of the measuring chamber fixedly connected with the liquid suction needle and the liquid injection needle, and the liquid suction needle and the liquid injection needle respectively pass through the measuring chamber
- the cover plate corresponds to the liquid suction level and the reaction cup on the liquid injection level.
- the needle tip of the liquid suction needle and the needle tip of the liquid injection needle have a certain height difference;
- the drive assembly includes a screw motor, a transmission screw, and a
- the screw nut fixed on the needle fixing plate of the upper screw drive, the driving seat fixed on the needle fixing plate, the linear guide rail arranged on the bracket and parallel to the driving screw rod, and the sliding rail fixed on the driving seat and matched with the linear guide rail.
- One end of the drive screw is connected to the output shaft of the screw motor, and the other end is connected to the cover plate of the measuring chamber through a bearing.
- the needle moves up and down, and drives the slider to move up and down along the linear guide through the needle fixing plate and the drive seat.
- the liquid injection and suction unit further includes a liquid injection needle sealing assembly and a liquid suction needle sealing assembly
- the liquid injection needle sealing assembly includes: a sealing column arranged on the cover plate of the measuring chamber, and arranged on the top of the sealing column
- the sealing column cover plate is provided with a first sealing plug connected to the sealing column cover plate in the groove at the top of the sealing column, and a first O-ring arranged on the outer periphery of the first sealing plug.
- a sealing plug and a sealing column are formed with a through hole for the liquid injection needle to pass through, the bottom of the sealing column is provided with an accommodating cavity whose diameter is larger than the outer diameter of the liquid injection needle;
- the liquid suction needle sealing assembly includes: A second sealing plug connected to the sealing plug cover plate arranged on the measuring chamber cover plate in the top groove of the chamber cover plate, and a second O-ring arranged on the outer periphery of the second sealing plug, the sealing plug cover plate, The second sealing plug is formed with a through hole for the liquid suction needle to pass through; preferably, between the liquid injection needle and the first sealing plug, between the liquid suction needle and the second sealing plug, and between the first O-ring and the first sealing plug Interference fit is used between the plugs, the second O-ring and the second sealing plug.
- the inner holes of the first sealing plug and the second sealing plug preferably adopt a conical hole structure, and the first sealing plug and the second sealing plug are preferably Made of wear-resistant black plastic.
- the bracket is composed of a top plate, a vertical plate and a base, the base is fixed on the cover plate of the measuring chamber, and the linear guide rail is arranged on the vertical plate; the upper and lower ends of the vertical plate are preferably provided with two limit pins, Used to limit the slider.
- an optocoupler baffle is installed on the drive base, and an optocoupler corresponding to the optocoupler baffle is installed on the vertical plate; before the turntable rotates, the optocoupler baffle and the optocoupler are sensed to communicate to the control system.
- Send a signal to reset the entire needle assembly preferably, the suction needle is connected to a waste liquid pipe, the waste liquid pipe is connected to a waste liquid pump, the liquid injection needle is connected to the liquid injection pipe, and the liquid injection pipe is connected to the liquid injection pump Connection; the tip of the aspiration needle and the tip of the liquid injection needle preferably have a certain height difference.
- the drive unit includes a rotating power mechanism and a rotating transmission mechanism
- the rotating transmission mechanism includes a rotating shaft, an active synchronous pulley and a driven synchronous pulley connected by a synchronous belt, one end of the rotating shaft is fixedly connected to the turntable through a bearing, and the other One end is connected to the driven synchronous pulley through a bearing and a collar, and the active synchronous pulley is fixedly connected to the rotating power mechanism;
- the drive unit further includes a reset mechanism, and the reset mechanism includes a reset optical coupler and a fixed
- the reset optocoupler block corresponding to the reset optocoupler at the bottom of the synchronous pulley, the reset optocoupler is fixed on the measurement chamber through the reset optocoupler bracket.
- the control system sends a signal to position each cuvette to the initial position.
- the door opening and closing unit includes a seat body, and a hatch and a hatch door drive motor and a drive screw mounted on the seat body.
- One end of the drive screw is connected to the output shaft of the drive motor, and the other end is connected to the hatch.
- the seat body The door is provided with a door opening corresponding to the opening of the cover plate of the measuring chamber. There are guide rails on both sides of the seat body. The operation of the door driving motor can drive the door to slide along the guide rail above the door opening.
- the luminescence measurement unit includes a photomultiplier tube, a rotary drive member mounted on the mounting plate, a baffle plate with a light-passing hole, the baffle plate is further formed with a chute, and the rotating drive member is driven by the rotary drive member and rotates on the cam
- the rotary rocker on the top is arranged in the chute, and when the rotary rocker rotates, the baffle moves horizontally through the cooperation with the chute, so that the through hole on the baffle and the photon via hole are coincident or misaligned;
- the rotary drive member includes a rotary drive motor and a drive shaft. One end of the drive shaft is connected to the output shaft of the drive motor, and the other end is connected to a cam.
- a positioning optocoupler block with openings corresponding to the door opening positioning optocoupler and the door closing positioning optocoupler is fixed on the upper part.
- the opening positioning optocoupler, the door closing positioning optocoupler, and the positioning optocoupler block are used to sense whether the photon via is blocked. The plate is blocked and a signal is sent to the control system to open or close the opening of the measurement chamber cover.
- the shaking unit includes an upper and lower displacement assembly and a shaking assembly.
- the upper and lower displacement assembly is used to control the lifting and lowering of the cuvette.
- the shaking assembly can drive the cuvette to rotate eccentrically;
- the up and down displacement assembly includes a lifting power mechanism, a horizontally arranged moving support plate and a vertically placed limit plate that are fixed together, and a linear guide rail arranged on the limit plate, and the lifting power mechanism drives the moving support plate along the The linear guide rail moves up and down;
- the shaker assembly includes a shaker power mechanism and an extension rod, the shaker power mechanism is connected with the moving support plate, one end of the extension rod is fixed with the shaker power mechanism, and the other end is fixed Connect the eccentric block, the eccentric block can slide up with the moving mechanism into the cuvette container position, and lift the cuvette in the cuvette container position to abut against the cuvette limit mechanism located above the shaking position, In this way, the cuvette is clamped and fixed
- the present invention also provides a luminescence measurement method for continuous measurement of multiple reaction cups, which is completed by using the luminescence measurement device for continuous measurement of multiple reaction cups according to any one of the embodiments, including the following steps:
- S1 Start the switch door unit to open the opening of the cover plate of the measuring chamber, perform the cuvette removal action for the cuvette pick-and-place position, and put the cuvette containing buffer 1 into the cuvette container corresponding to the cuvette pick-and-place position position, and then close the opening of the cover plate of the measuring chamber through the door switch unit;
- the liquid injection and liquid suction unit is used to perform suction action on the waste liquid in the cuvette; for the cuvette transferred to the cuvette pick and place position, the cuvette removal action is performed, and then A new cuvette is placed on the cuvette pick-and-place position; the liquid injection or luminescence measurement action or the cuvette placement or removal action can be performed simultaneously with the cuvette shaking and liquid aspiration respectively, and the liquid injection or luminescence measurement can be performed simultaneously.
- the action and the placement or removal of the cuvette cannot be performed at the same time.
- the luminescence measurement unit is started before the liquid injection and suction unit is performed; Always perform aspiration during the process until the aspiration needle touches the bottom of the cuvette. When the tip of the injection needle enters the cuvette, start the injection. When the aspiration needle touches the bottom of the cuvette, the injection needle cannot touch the bottom of the cuvette. buffer.
- the cuvette luminescence measurement device and the luminescence measurement method of the present invention can process the luminescence measurement of multiple cuvettes in parallel.
- the flow between different stations of the liquid suction level can make the liquid injection or luminescence measurement action or the placement or removal of the reaction cup to be carried out simultaneously with the shaking and liquid suction actions of the reaction cup respectively, which greatly saves the test time; liquid injection And the liquid suction unit has both liquid injection and liquid suction functions.
- the cuvette After the luminescence measurement is completed by injecting buffer 2, the cuvette can be transferred to the next station (liquid suction position), so that the waste liquid of the cuvette can be directly discharged to the Recycling and centralized processing are carried out outside the system, and then the reaction cup can be transferred to the next station to take away the reaction cup without waste liquid, which realizes the dry and wet separation treatment of waste liquid and the used reaction cup, with a high degree of automation.
- Example 1 is a schematic diagram of the overall structure of the luminescence measurement device for continuous measurement of multiple reaction cups according to Example 1 of the present application;
- FIG. 2 is a schematic structural diagram of a measurement chamber (with a measurement chamber cover plate) in Embodiment 1 of the present application;
- Fig. 3 is the structural schematic diagram of the measurement chamber (without the measurement chamber cover plate) of Example 1 of the present application;
- FIG. 4 is a schematic structural diagram of a drive unit according to Embodiment 1 of the present application.
- FIG. 5 is a schematic structural diagram of the door switch unit according to Embodiment 1 of the present application.
- Example 6 is a schematic structural diagram of the luminescence measurement unit of Example 1 of the present application.
- FIG. 8 is a schematic structural diagram of a positioning optocoupler blocking plate according to Embodiment 1 of the present application.
- Fig. 9 is the structural representation of the shaking unit of the embodiment 1 of the present application.
- Example 12 is a cross-sectional view of the liquid injection and liquid suction unit of Example 1 of the present application.
- the reference numbers in the figure are: 1-measuring chamber, 101-measuring chamber cover, 102-turntable, 1021-reservoir position, 103-fixing flange, 2-drive unit, 201-drive motor, 202- Rotary transmission mechanism bracket, 203-fixed column, 204-active synchronous pulley, 205-synchronous belt, 206-driven synchronous pulley, 207-reset optocoupler bracket, 208-reset optocoupler, 209-reset optocoupler baffle , 210-bearing, 211-rotating shaft, 3-opening and closing door unit, 301-seat body, 302-cabin door, 303-cabin door drive motor, 304-transmission screw, 4-luminescence measuring unit, 401-photomultiplier tube , 402-Bezel, 4021-Chute, 4022-Light Hole, 403-Cam, 4031-Rotary Rocker, 404-Rotary Drive, 4041-Rotary Drive Motor, 40
- the terms “installed”, “connected” and “connected” should be understood in a broad sense, for example, it may be a fixed connection or a detachable connection Connection, or integral connection; can be mechanical connection, can also be electrical connection; can be directly connected, can also be indirectly connected through an intermediate medium, can be internal communication between two elements.
- installed should be understood in a broad sense, for example, it may be a fixed connection or a detachable connection Connection, or integral connection; can be mechanical connection, can also be electrical connection; can be directly connected, can also be indirectly connected through an intermediate medium, can be internal communication between two elements.
- This embodiment provides a luminescence measurement device for continuous measurement of multiple reaction cups, as shown in FIG. 1 , including:
- the measurement chamber 1 is provided with a measurement chamber cover plate 101 with an opening on the top, a photon via hole on the side, and an accommodating cavity for accommodating the turntable 102 inside, and the opening is used for the reaction Put the cup into the cuvette accommodating position 1021 or remove the cuvette from the cuvette accommodating position 1021, the turntable 102 is provided with a plurality of cuvette containers arranged along the circumference of the turntable 102 for accommodating the cuvette bit 1021;
- the drive unit 2 is used to drive the turntable 102 to rotate, including a rotary power mechanism and a rotary transmission mechanism, and the rotary transmission mechanism is connected with the turntable 102 of the measurement chamber 1;
- the bracket 202 and the fixed column 203 arranged on the bracket 202 of the rotary transmission mechanism are fixed on the measurement chamber 1;
- One end of the shaft 211 is fixedly connected with the turntable 102 through the bearing 210, the other end is connected with the driven synchronous pulley 206 through the bearing 210 and the collar 214, and the driving synchronous pulley 204 is fixedly connected with the rotating power mechanism;
- the bearing 210 is installed in the measuring chamber In the bearing hole at the bottom, the rotating shaft 211 is connected to the turntable 102 through the fixed flange 103 on the turntable 102; when the drive unit 2 drives the turntable 102 to rotate, the reaction cup can be successively placed in the reaction cup, shaken evenly, and injected Or the luminescence measurement position and the liquid suction position flow between different stations
- the reset mechanism includes a reset optocoupler 208 and a reset optocoupler block 209 corresponding to the reset optocoupler 208 installed at the bottom of the driven synchronous pulley 206, and the reset optocoupler 208 is fixed on the measurement chamber through the reset optocoupler bracket 207 , before the formal test, through the induction of the reset optocoupler 208 and the reset optocoupler baffle 209, so as to send a signal to the control system, so that each cuvette container position 1021 is positioned to the initial position;
- the door switch unit 3 as shown in FIG. 5, is arranged on the cover plate 101 of the measurement chamber, and is used to open or close the opening on the cover plate 101 of the measurement chamber;
- the door switch unit 3 includes a base body 301, and is installed on the The cabin door 302 on the body 301, the cabin door drive motor 303 and the drive screw 304, one end of the drive screw 304 is connected to the output shaft of the drive motor 303, and the other end is connected to the cabin door 302.
- the opening of the chamber cover 101 corresponds to the opening of the cover plate 101, and guide rails are provided on both sides of the seat body 301.
- the operation of the door drive motor 303 can drive the hatch door 302 to slide above the door opening along the guide rail; when the door is required to be closed, the drive motor 303 can be operated to run Make the hatch 302 slide to the top of the door opening until the door is covered; when the door needs to be opened to add samples, the drive motor 303 can also be operated to make the hatch 302 slide away from the top of the door;
- the luminescence measurement unit 4 can close or open the photon via hole on the measurement chamber 1, and collect the contents in the cuvette on the liquid injection or luminescence measurement position when the photon via hole is opened.
- the amount of light emitted by the photomultiplier tube 401, the rotary drive member 404 installed on the mounting plate 405, the baffle plate 402 with the light-passing hole 4022, and the baffle plate 402 is also formed with a chute 4021, which is driven by the rotary drive member 404.
- the rotating rocker 4031 located on the cam 403 is arranged in the chute 4021.
- the rotary rocker 4031 When the rotary rocker 4031 rotates, it cooperates with the chute 4021 to make the baffle plate 402 move horizontally, so that the through holes on the baffle plate 402 can be moved horizontally.
- 4022 coincides with the photon via hole (the baffle 402 does not block the photons) or is dislocated (the baffle 402 blocks the photons); when in use, before the hatch 302 is opened, the baffle 402 is driven to move by the rotating driver 404, so that the baffle 402
- the light-passing hole 4022 on the top is dislocated from the photon via hole, which can block the lens of the photomultiplier tube 401, prevent external light from entering the photomultiplier tube 401, and ensure the service life and accuracy of the photomultiplier tube 401; after closing the door 302 , the baffle 402 is driven to move by the rotating drive member 404, so that the light-passing holes 4022 on the baffle 402 coincide with the photon via holes, so
- One end of the drive shaft 4042 is connected to the output shaft of the drive motor 4041, and the other end is connected to the cam 403.
- On both sides of the drive shaft 4042 are provided with an opening positioning optocoupler 407, a door closing positioning optocoupler Optocoupler 408, and a positioning optocoupler block 406 with an opening corresponding to the opening positioning optocoupler 407 and the door closing positioning optocoupler 408 is fixedly arranged on the drive shaft 412, the opening positioning optocoupler 407, the door closing positioning optocoupler 408,
- the positioning of the optocoupler shutter 406 is used to sense whether the photon via is blocked by the shutter 402, and to send a signal to the control system to open or close the opening of the measurement chamber cover 101;
- the lens of the photomultiplier tube 401 is aligned with the light-passing hole 4022.
- the door drive assembly 303 is prevented from opening the opening of the measurement chamber cover 101 to prevent the photomultiplier tube 401 from being irradiated by external light.
- the gap 4061 on the positioning optocoupler baffle 406 is aligned with the door closing positioning optocoupler 408, the lens of the photomultiplier tube 401 is blocked by the baffle 402, at this time, the hatch drive assembly 303 can be activated to open the measurement chamber the opening of the cover plate 101;
- the shaking unit 5, as shown in Figure 9, is used to perform the shaking action on the cuvette turned to the shaking position, including the up and down displacement assembly and the shaking assembly.
- the up and down displacement assembly is used to control the lifting and lowering of the cuvette.
- the shaker assembly can drive the cuvette to rotate eccentrically;
- the up and down displacement assembly includes a lifting power mechanism 501, a horizontally arranged moving support plate 502 and a vertically placed limit plate 503 that are fixed together, and the On the linear guide rail on the limit plate 503, the lifting power mechanism 501 drives the moving support plate 502 to move up and down along the linear guide rail;
- the support plate 502 is connected, one end of the extension rod 505 is fixed with the shaking power mechanism 502, and the other end is fixed with an eccentric block 506, and the eccentric block 506 can slide upward with the moving mechanism 502 and penetrate into the cuvette storage position 1021, and
- the cuvette located in the cuvette holding position 1021 is lifted up to abut against the cuvette limit mechanism located above the shaking position
- the liquid injection and liquid suction unit 6 is used for injecting liquid into the cuvette corresponding to the liquid injection level and extracting waste liquid from the cuvette corresponding to the liquid suction level.
- FIG. 10 it includes a bracket 601, a drive assembly 602, a needle Assembly 603;
- the bracket 601 is composed of a top plate 6011, a vertical plate 6012, and a base 6013, and the base 6013 is fixed on the cover plate 101 of the measuring chamber;
- the needle assembly 603 includes a liquid suction needle 6032, a liquid injection needle 6033, and a liquid suction needle 6031.
- the needle fixing plate 6031 on the upper part of the measuring chamber cover plate 101 is fixedly connected with the liquid injection needle 6033.
- the liquid suction needle 6032 and the liquid injection needle 6033 respectively pass through the measuring chamber cover plate 101 and correspond to the liquid suction level and the liquid injection level. There is a certain height difference between the tip of the aspiration needle 6032 and the tip of the injection needle 6033; further, the tip of the aspiration needle 6032 is provided with a notch, which can prevent the tip of the aspiration needle 6032 from sticking to the bottom of the cuvette.
- the injection needle 6033 has a tapered needle tip 321 to prevent the activator injection needle 6033 from hanging up with liquid;
- the drive assembly 602 includes a screw motor 6021, a transmission screw 6022, and the transmission screw 6022
- the screw nut 6034 fixed on the needle fixing plate 6031 of the upper screw drive, the driving seat 6023 fixed on the needle fixing plate 6031, the linear guide 6027 arranged on the vertical plate 6012 and parallel to the driving screw 6022 and fixed on the driving
- the slider 6026 on the seat 6023 is matched with the linear guide 6027.
- One end of the drive screw 6022 is connected to the output shaft of the screw motor 6021, and the other end is connected to the measuring chamber cover plate 101 through a bearing.
- the injection needle 6022 can make the suction needle 6032 and the liquid injection needle 6033 fixed on the needle fixing plate 6031 move up and down, and drive the slider 6026 to move up and down along the linear guide 6027 through the needle fixing plate 6031 and the driving seat 6023 to ensure that the suction needle 6032,
- the injection needle 6033 keeps smooth when running up and down;
- the liquid injection and suction unit 6 further includes a liquid injection needle seal assembly 604 and a liquid suction needle seal assembly 605, and the liquid injection needle seal assembly 604 and the liquid suction needle seal assembly 605 are used for the liquid injection needle 6033 and the liquid suction needle seal assembly 605.
- the needle 6032 moves up and down, it acts as a seal to prevent the entry of external light.
- the liquid injection needle sealing assembly 604 includes: a sealing column 6043 arranged on the cover plate 101 of the measuring chamber, a sealing column arranged on the top of the sealing column 6043 A cover plate 6044, a first sealing plug 6042 connected to the sealing column cover plate 6044 in the top groove of the sealing column 6043, and a first O-ring 6041 arranged on the outer periphery of the first sealing plug 6042, the sealing column cover
- the plate 6044, the first sealing plug 6042, and the sealing column 6043 are formed with a through hole for the liquid injection needle 6033 to pass through, and the bottom of the sealing column 6043 is provided with an accommodating cavity whose diameter is larger than the outer diameter of the liquid injection needle; the liquid suction
- the needle sealing assembly 5 includes: a second sealing plug 6052 disposed in the top groove of the measuring chamber cover plate 101 and connected to the sealing plug cover plate 6051 disposed on the measuring chamber cover plate 101, and a second sealing plug 6052 disposed on the outer periphery of the second sealing plug 6052 The second O
- the first sealing plug 6042 , The inner hole of the second sealing plug 6052 adopts a tapered hole structure, and the first sealing plug 6042 and the second sealing plug 6052 are further made of wear-resistant black plastic, such as black PTFE, black high hardness PU, black UPE, etc., which can effectively avoid external light. Enter the measuring chamber interior chamber.
- wear-resistant black plastic such as black PTFE, black high hardness PU, black UPE, etc.
- the upper and lower ends of the vertical plate 6012 are provided with two limit pins 6028, which are used to limit the slider 6026, that is, when the entire mechanism fails, the suction needle 6032 and the liquid injection needle 6033 will not be caused. Run up or down without limit to avoid malfunctions such as puncturing the cuvette.
- an optocoupler blocking piece 6024 is installed on the drive base 6023, and an optocoupler 6025 corresponding to the optocoupler blocking piece 6024 is installed on the vertical plate 6012; 6025, so as to send a signal to the control system to realize the reset of the entire needle assembly 603; when the needle assembly 603 is in the home position, the aspiration needle 6032 and the injection needle 6033 are located above the cup hole of the corresponding reaction cup (greater than 4mm), In order to prevent the needle tip from interfering with the rotation of the cuvette and causing malfunction, the needle tips of the liquid aspirating needle 6032 and the liquid injection needle 6033 cannot be separated from the inner hole of the sealing plug 6042, so as to prevent the liquid aspirating needle 6032 and the liquid injection needle 6033 from being unable to align when they run downward again. Sealing plug 6042 inner hole.
- the suction needle 6032 is connected with the waste liquid pipe, and the waste liquid pipe is connected with the waste liquid pump; the liquid injection needle 6033 is connected with the liquid injection pipe, and the liquid injection pipe is connected with the liquid injection pump; The liquid needle 6032 and the liquid injection needle 6033 slowly descend under the drive of the screw motor 6021. During the descending process, the waste liquid pump is always in the working state until the liquid suction needle 6032 touches the bottom of the cuvette, and when the needle tip of the liquid injection needle 6033 enters the The liquid injection pump starts to work when the cuvette 7 is in the cuvette 7. In the past, the activator was injected into the cuvette. When the suction needle 6032 touched the bottom of the cuvette, the liquid injection needle 6033 could not touch the activator in the cuvette.
- the cuvette When in use, when the cuvette rotates below the liquid injection needle 6033, it is at the liquid injection level; when the cuvette is rotated to the bottom of the liquid suction needle 6032, it is at the liquid suction level. In the continuous test, the previous cuvette is in the suction liquid position. When it is in position, the latter cuvette is at the liquid injection position, that is, suction of waste liquid and injection of activator are carried out at the same time, which greatly saves the test time.
- This embodiment provides a luminescence measurement method for continuous measurement of multiple cups, which is completed by using the luminescence measurement device for continuous measurement of multiple reaction cups in Embodiment 1, including the following steps:
- S1 Activate the door switch unit 3 to open the opening of the cover plate 101 of the measurement chamber 1, and perform the cuvette removal action for the cuvette pick-and-place position (there is no cuvette at the beginning of the test, and the empty grab action is performed), and the buffer solution will be filled. Put the cuvette of 1 into the cuvette storage position 1021 corresponding to the cuvette pick-and-place position, and then close the opening of the cover plate 101 of the measurement chamber 1 through the door switch unit 3;
- the action of taking out the cuvette, and then placing a new cuvette on the cuvette pick-and-place position; the liquid injection or luminescence measurement action or the placing or taking action of the cuvette can be done at the same time as the shaking and aspirating actions of the cuvette respectively.
- the placing or removal of the cuvette cannot be performed at the same time.
- the photon via hole on the measurement chamber 1 is closed by the luminescence measurement unit 4 when the cuvette is placed or removed to prevent the photomultiplier tube 401 from being damaged by exposure; when the turntable 102 rotates, the placement or removal of the cuvette ,
- the reaction cup should be shaken, liquid injection or luminescence measurement, and liquid suction should stop running.
- the luminescence measurement unit 4 is activated before the liquid injection and suction unit 6 performs liquid injection, that is, the photon via hole and the photomultiplier tube 401 are opened to collect the substances in the cuvette.
- the amount of light emitted can prevent leakage of collected photons and improve the collection accuracy.
- continuously collecting the number of photons to obtain the total number of photons in a period of time can obtain higher accuracy than when collecting the number of photons intermittently.
- the liquid suction needle 6032 and the liquid injection needle 6033 slowly descend under the driving of the screw motor 6021.
- the waste liquid pump is always In the working state, until the suction needle 6032 touches the bottom of the cuvette, and when the tip of the liquid injection needle 6033 enters the cuvette 7, the liquid injection pump starts to work.
- the activator was injected into the cuvette. At the bottom, the injection needle 6033 cannot touch the solution in the cuvette.
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Abstract
Description
Claims (10)
- 一种多反应杯连续测量的发光测量装置,其特征在于,包括:测量室(1),顶部设置有具有开口的测量室盖板(101),侧面开设有光子过孔,内部具有用于容纳转盘(102)的容纳腔,所述转盘(102)上开设有多个沿转盘(102)周向设置的用于容纳反应杯的反应杯容置位(1021),所述开口用于将反应杯放入反应杯容置位(1021)内或将反应杯从反应杯容置位(1021)取走;驱动单元(2),用于驱动转盘(102)旋转,使反应杯先后在反应杯取放位、摇匀位、注液或发光测量位、吸液位的不同工位间流转;开关门单元(3),用于使测量室盖板(101)上的开口开启或关闭;摇匀单元(5),用于对转至摇匀位的反应杯执行摇匀动作;发光测量单元(4),能够封闭或打开测量室(1)上的光子过孔,并在打开光子过孔时采集注液或发光测量位上的反应杯内物质的发光量;注液及吸液单元(6),用于向注液位对应的反应杯内注液并从向吸液位对应反应杯内抽取废液,包括固定于测量室盖板(101)上的支架(601)、驱动组件(602)、针组件(603);所述针组件(603)包括吸液针(6032)、注液针(6033)以及与吸液针(6031)、注液针(6033)固连的位于测量室盖板(101)上部的针固定板(6031),所述吸液针(6032)、注液针(6033)分别穿过测量室盖板(101)并对应吸液位、注液位上的反应杯,吸液针(6032)针尖和注液针(6033)针尖具有一定的高度差;所述驱动组件(602)包括丝杆电机(6021)、传动丝杆(6022)、于所述传动丝杆(6022)上螺旋传动的固连于针固定板(6031)上的丝杆螺母(6034)、固定于针固定板(6031)上的驱动座(6023)、设置于支架(601)上与传动丝杆(6022)平行的直线导轨(6027)及固定于驱动座(6023)上与直线导轨(6027)配合的滑块(6026),所述传动丝杆(6022)一端连接丝杆电机(6021)的输出轴,另一端通过轴承与测量室盖板(101)连接,通过丝杆电机(6021)、传动丝杆(6022)可使固定于针固定板(6031)上的吸液针(6032)、注液针(6033)上下移动,并通过针固定板(6031)、驱动座(6023)带动滑块(6026)沿直线导轨(6027)上下移动。
- 根据权利要求1所述的多反应杯连续测量的发光测量装置,其特征在于,所述注液及吸液单元(6)还包括注液针密封组件(604)和吸液针密封组件(605),所述注液针密封组件(604)包括:设置于测量室盖板(101)上 的密封柱(6043),设于密封柱(6043)顶部的密封柱盖板(6044),设于密封柱(6043)顶部凹槽内与密封柱盖板(6044)相接的第一密封塞(6042),以及设置于第一密封塞(6042)外周的第一O形圈(6041),所述密封柱盖板(6044)、第一密封塞(6042)、密封柱(6043)形成有供注液针(6033)穿过的通孔,所述密封柱(6043)底部开设有直径比注液针外径大的容纳空腔;所述吸液针密封组件(5)包括:设置于测量室盖板(101)顶部凹槽内与设于测量室盖板(101)上的密封塞盖板(6051)相接的第二密封塞(6052),以及设置于第二密封塞(6052)外周的第二O形圈(6053),所述密封塞盖板(6051)、第二密封塞(6052)形成有供吸液针(6032)穿过的通孔;优选地,注液针(6033)与第一密封塞(6042)之间、吸液针(6032)与第二密封塞(6052)之间、第一O形圈(6041)与第一密封塞(6042)之间、第二O形圈(6053)与第二密封塞(6052)之间均采用过盈配合,第一密封塞(6042)、第二密封塞(6052)内孔优选采用锥形孔结构,第一密封塞(6042)、第二密封塞(6052)优选采用耐磨黑色塑料。
- 根据权利要求1或2所述的多反应杯连续测量的发光测量装置,其特征在于,所述支架(601)由顶板(6011)、立板(6012)、底座(6013)组成,底座(6013)固定于测量室盖板(101)上,直线导轨(6027)设置于立板(6027)上;所述立板(6012)的上下两端优选为设有两个限位销(6028),用于对滑块(6026)进行限位。
- 根据权利要求1-3任一项所述的多反应杯连续测量的发光测量装置,其特征在于,所述驱动座(6023)上安装有光耦挡片(6024),所述立板(6012)上安装有光耦挡片(6024)相应的光耦(6025);在转盘(102)转动前,通过光耦挡片(6024)和光耦(6025)的感应,从而向控制系统发送信号,实现整个针组件(603)的复位;优选地,所述吸液针(6032)与废液管连接,废液管连接废液泵,所述注液针(6033)与注液管连接,注液管与注液泵连接。
- 根据权利要求1-4任一项所述的多反应杯连续测量的发光测量装置,其特征在于,所述驱动单元(2)包括旋转动力机构和旋转传动机构,旋转传动机构包括旋转轴(211)及通过同步带(205)相连的主动同步带轮(204)、从动同步带轮(206),旋转轴(211)一端通过轴承(210)与转盘(102)固定连接,另一端通过轴承(210)和轴环(214)与从动同步带轮(206)相连,主 动同步带轮(204)与旋转动力机构固定连接;优选地,所述驱动单元(2)还包括复位机构,所述复位机构包括复位光耦(208)和安装于从动同步带轮(206)底部的与复位光耦(208)相应的复位光耦挡片(209),复位光耦(208)通过复位光耦支架(207)固定于测量室上,正式测试之前,通过复位光耦(208)与复位光耦挡片(209)的感应,从而向控制系统发送信号,使各反应杯容置位(1021)定位到初始位置。
- 根据权利要求1-5任一项所述的多反应杯连续测量的发光测量装置,其特征在于,所述开关门单元(3)包括座体(301),以及安装于座体(301)上的舱门(302)和舱门驱动电机(303)和传动丝杆(304),传动丝杆(304)一端连接驱动电机(303)的输出轴,另一端连接舱门(302),座体(301)上设有门洞,门洞与测量室盖板(101)的开口相对应,座体(301)两侧设有导轨,舱门驱动电机(303)的运行可带动舱门(302)沿导轨在门洞上方滑动。
- 根据权利要求1-6任一项所述的多反应杯连续测量的发光测量装置,其特征在于,所述发光测量单元(4)包括光电倍增管(401)、安装于安装板(405)上的旋转驱动件(404)、具有通光孔(4022)的挡板(402),挡板(402)上还成型有滑槽(4021),受旋转驱动件(404)驱动而转动的位于凸轮(403)上的旋转摇杆(4031)设置在滑槽(4021)内,旋转摇杆(4031)转动时,通过与滑槽(4021)的配合,使挡板(402)做水平运动,从而使挡板(402)上的通孔(4022)与光子过孔重合或者错位;优选地,所述旋转驱动件(404)包括旋转驱动电机(4041)和驱动轴(4042),驱动轴(4042)一端连接驱动电机(4041)的输出轴,另一端连接凸轮(403),在驱动轴(4042)的两侧设置有开门定位光耦(407)、关门定位光耦(408),并在驱动轴(412)上固定设置有与开门定位光耦(407)、关门定位光耦(408)相对应的具有开口的定位光耦挡片(406),开门定位光耦(407)、关门定位光耦(408)、定位光耦挡片(406)用于感应光子过孔是否被挡板(402)遮挡,并向控制系统发送信号以使使测量室盖板(101)的开口打开或关闭。
- 根据权利要求1-7任一项所述的多反应杯连续测量的发光测量装置,其特征在于,所述摇匀单元(5)包括上下位移组件和摇匀组件,上下位移组件用于控制反应杯的升降,当上下位移组件带动反应杯上升时,摇匀组件能 够带动反应杯偏心转动;优选地,上下位移组件包括升降动力机构(501)、固连在一起的水平设置的移动支板(502)和竖直放置的限位板(503),以及设置于限位板(503)上的直线导轨,升降动力机构(501)驱动所述移动支板(502)沿直线导轨上下移动;优选地,摇匀组件包括摇匀动力机构(504)和延长杆(505),摇匀动力机构(502)与所述移动支板(502)相连,所述延长杆(505)一端与所述摇匀动力机构(502)固接,另一端固连偏心块(506),偏心块(506)能够随移动机构(502)向上滑动深入反应杯容置位(1021)中,并将位于反应杯容置位(1021)中的反应杯顶起至与位于摇匀位上方的反应杯限位机构相抵接,这样反应杯被位于上方的反应杯限位机构和位于下方的偏心块(506)夹住固定。
- 一种多反应杯连续测量的发光测量方法,其特征在于,采用实施例1-8任一项所述的多反应杯连续测量的发光测量装置完成,包括如下步骤:S1:启动开关门单元(3)打开测量室(1)盖板(101)的开口,对反应杯取放位执行反应杯取走动作,并将装有缓冲液1的反应杯放入反应杯取放位对应的反应杯容置位(1021)内,之后通过开关门单元(3)关闭测量室(1)盖板(101)的开口;S2:通过驱动单元(2)带动转盘(102)转动,使反应杯容置位(1021)内的反应杯依次在反应杯取放位、摇匀位、注液位、吸液位的不同工位间流转,对于转至摇匀位的反应杯通过摇匀单元(4)执行摇匀动作,对于转至注液位的反应杯通过注入缓冲液2及吸液单元(6)进行注液并通过发光测量单元(4)打开光子过孔以采集反应杯内物质的发光量,对于转至吸液位的反应杯通过注液及吸液单元(6)对反应杯内的废液执行吸液动作,对于转至反应杯取放位的反应杯执行反应杯取走动作,再在反应杯取放位上放置新的反应杯;所述注液或发光测量动作或是反应杯的放置或取走动作可分别与反应杯的摇匀、吸液动作同时进行,注液或发光测量动作及反应杯的放置或取走动作不可同时进行,在进行注液或发光测量时关闭测量室(1)盖板(101)的开口,在进行反应杯的放置或取走动作时通过发光测量单元(4)关闭测量室(1)上的光子过孔。
- 根据权利要求9所述的多反应杯连续测量的发光测量方法,其特征在于,在通过注液及吸液单元(6)进行注液前就启动发光测量单元(4);优选地,在注液和吸液时,吸液针(6032)和注液针(6033)在丝杆电机(6021) 驱动下缓慢下降,在下降过程中始终进行吸液,直至吸液针(6032)触及反应杯底部,当注液针(6033)的针尖进入反应杯(7)内时开始注液,当吸液针(6032)触及反应杯底部时,注液针(6033)不能触及反应杯内的缓冲液。
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