WO2021221169A1 - Pyrimidin-4(3h)-one derivatives as trpv4 antagonists - Google Patents
Pyrimidin-4(3h)-one derivatives as trpv4 antagonists Download PDFInfo
- Publication number
- WO2021221169A1 WO2021221169A1 PCT/JP2021/017277 JP2021017277W WO2021221169A1 WO 2021221169 A1 WO2021221169 A1 WO 2021221169A1 JP 2021017277 W JP2021017277 W JP 2021017277W WO 2021221169 A1 WO2021221169 A1 WO 2021221169A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cyclopropyl
- azepin
- pyrimido
- hexahydro
- phenyl
- Prior art date
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- DNCYBUMDUBHIJZ-UHFFFAOYSA-N 1h-pyrimidin-6-one Chemical class O=C1C=CN=CN1 DNCYBUMDUBHIJZ-UHFFFAOYSA-N 0.000 title abstract description 8
- 239000005557 antagonist Substances 0.000 title description 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 64
- 208000035475 disorder Diseases 0.000 claims abstract description 50
- 102000003567 TRPV4 Human genes 0.000 claims abstract description 41
- 101150098315 TRPV4 gene Proteins 0.000 claims abstract description 41
- 238000000034 method Methods 0.000 claims abstract description 28
- 230000036407 pain Effects 0.000 claims abstract description 27
- 238000011282 treatment Methods 0.000 claims abstract description 26
- 230000002757 inflammatory effect Effects 0.000 claims abstract description 23
- 208000014001 urinary system disease Diseases 0.000 claims abstract description 20
- 208000012931 Urologic disease Diseases 0.000 claims abstract description 14
- 208000027866 inflammatory disease Diseases 0.000 claims abstract description 14
- 208000027753 pain disease Diseases 0.000 claims abstract description 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 284
- -1 nitro, hydroxyl Chemical group 0.000 claims description 208
- 150000001875 compounds Chemical class 0.000 claims description 155
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 124
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 104
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 98
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 98
- 125000001072 heteroaryl group Chemical group 0.000 claims description 94
- 229910052736 halogen Inorganic materials 0.000 claims description 75
- 125000001424 substituent group Chemical group 0.000 claims description 75
- 125000000217 alkyl group Chemical group 0.000 claims description 74
- 150000002367 halogens Chemical class 0.000 claims description 74
- 229910052757 nitrogen Chemical group 0.000 claims description 74
- 125000003118 aryl group Chemical group 0.000 claims description 70
- 229910052739 hydrogen Inorganic materials 0.000 claims description 70
- 239000001257 hydrogen Substances 0.000 claims description 69
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 68
- 125000003545 alkoxy group Chemical group 0.000 claims description 63
- GLZXFITXXAMCRJ-UHFFFAOYSA-N azepin-4-one Chemical compound O=C1C=CC=NC=C1 GLZXFITXXAMCRJ-UHFFFAOYSA-N 0.000 claims description 62
- 150000003839 salts Chemical class 0.000 claims description 56
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 54
- 125000000623 heterocyclic group Chemical group 0.000 claims description 54
- 229910052760 oxygen Inorganic materials 0.000 claims description 52
- 229910052717 sulfur Inorganic materials 0.000 claims description 51
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 50
- 125000005842 heteroatom Chemical group 0.000 claims description 49
- 150000002431 hydrogen Chemical class 0.000 claims description 44
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 35
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 27
- 239000001301 oxygen Substances 0.000 claims description 27
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 26
- 208000004296 neuralgia Diseases 0.000 claims description 26
- 239000011593 sulfur Chemical group 0.000 claims description 26
- 208000002193 Pain Diseases 0.000 claims description 25
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 23
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 21
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 21
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 20
- 125000000000 cycloalkoxy group Chemical group 0.000 claims description 20
- 125000002883 imidazolyl group Chemical group 0.000 claims description 20
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 20
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 20
- 125000004429 atom Chemical group 0.000 claims description 19
- 125000003373 pyrazinyl group Chemical group 0.000 claims description 19
- 125000002098 pyridazinyl group Chemical group 0.000 claims description 19
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims description 18
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims description 18
- 125000002541 furyl group Chemical group 0.000 claims description 18
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 18
- 125000002971 oxazolyl group Chemical group 0.000 claims description 18
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 18
- 125000001544 thienyl group Chemical group 0.000 claims description 18
- 239000000126 substance Substances 0.000 claims description 17
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims description 16
- 229910003827 NRaRb Inorganic materials 0.000 claims description 16
- 206010037211 Psychomotor hyperactivity Diseases 0.000 claims description 16
- 125000001624 naphthyl group Chemical group 0.000 claims description 16
- 125000000168 pyrrolyl group Chemical group 0.000 claims description 16
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 15
- 125000000335 thiazolyl group Chemical group 0.000 claims description 15
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- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 12
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims description 12
- 229910052705 radium Inorganic materials 0.000 claims description 12
- 229910052701 rubidium Inorganic materials 0.000 claims description 12
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 11
- 206010020853 Hypertonic bladder Diseases 0.000 claims description 11
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims description 11
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- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims description 11
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- 210000003932 urinary bladder Anatomy 0.000 claims description 10
- 125000006771 (C1-C6) haloalkylthio group Chemical group 0.000 claims description 9
- 241001465754 Metazoa Species 0.000 claims description 9
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- 125000001715 oxadiazolyl group Chemical group 0.000 claims description 9
- 239000012453 solvate Substances 0.000 claims description 9
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims description 8
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims description 8
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims description 8
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims description 8
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims description 8
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 claims description 8
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 8
- 208000004550 Postoperative Pain Diseases 0.000 claims description 8
- 208000003251 Pruritus Diseases 0.000 claims description 8
- 125000005103 alkyl silyl group Chemical group 0.000 claims description 8
- 230000003042 antagnostic effect Effects 0.000 claims description 8
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 8
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims description 8
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims description 8
- 208000002551 irritable bowel syndrome Diseases 0.000 claims description 8
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- 125000004043 oxo group Chemical group O=* 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- SQVKTYPDFXSZIC-UHFFFAOYSA-N 6-[2-(3,5-difluorophenyl)-2-hydroxyacetyl]-2-[1-(3-fluorophenyl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound OC(C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(F)=CC=C1)NC2=O)=O)C1=CC(F)=CC(F)=C1 SQVKTYPDFXSZIC-UHFFFAOYSA-N 0.000 claims description 7
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 7
- 230000001404 mediated effect Effects 0.000 claims description 7
- RDGPKDXMWIUPEC-UHFFFAOYSA-N 6-[2-hydroxy-2-(3-methylphenyl)acetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound CC1=CC(C(C(N(CC2)CC3=C2N=C(C2(CC2)C2=CC=CC=C2)NC3=O)=O)O)=CC=C1 RDGPKDXMWIUPEC-UHFFFAOYSA-N 0.000 claims description 6
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims description 6
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- 208000009722 Overactive Urinary Bladder Diseases 0.000 claims description 6
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- 208000006561 Cluster Headache Diseases 0.000 claims description 5
- 206010071289 Lower urinary tract symptoms Diseases 0.000 claims description 5
- 125000002393 azetidinyl group Chemical group 0.000 claims description 5
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 5
- 125000004438 haloalkoxy group Chemical group 0.000 claims description 5
- 208000028867 ischemia Diseases 0.000 claims description 5
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- 230000004770 neurodegeneration Effects 0.000 claims description 5
- 230000001272 neurogenic effect Effects 0.000 claims description 5
- 125000003566 oxetanyl group Chemical group 0.000 claims description 5
- 125000004193 piperazinyl group Chemical group 0.000 claims description 5
- 125000003386 piperidinyl group Chemical group 0.000 claims description 5
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 5
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims description 5
- HCMJWOGOISXSDL-UHFFFAOYSA-N (2-isothiocyanato-1-phenylethyl)benzene Chemical compound C=1C=CC=CC=1C(CN=C=S)C1=CC=CC=C1 HCMJWOGOISXSDL-UHFFFAOYSA-N 0.000 claims description 4
- GKXIQTAKTNCATG-SSEXGKCCSA-N 1-[4-[3-[1-[6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-2-yl]cyclopropyl]phenyl]phenyl]cyclopropane-1-carbonitrile Chemical compound N#CC1(CC1)C(C=C1)=CC=C1C1=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(Cl)=CC=C4)O)=O)=C3C2=O)=CC=C1 GKXIQTAKTNCATG-SSEXGKCCSA-N 0.000 claims description 4
- YLGFCBPUEFFPIV-UHFFFAOYSA-N 2-(1-phenylcyclopropyl)-6-[2-(2-phenylmethoxyphenyl)acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC(C=CC=C1)=C1OCC1=CC=CC=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O YLGFCBPUEFFPIV-UHFFFAOYSA-N 0.000 claims description 4
- MOWVKVRJDNCJSF-UHFFFAOYSA-N 2-(1-phenylcyclopropyl)-6-[2-(3-phenylmethoxyphenyl)acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC(OCC2=CC=CC=C2)=CC=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O MOWVKVRJDNCJSF-UHFFFAOYSA-N 0.000 claims description 4
- OYKVFHYFGRQFRX-UHFFFAOYSA-N 2-(1-phenylcyclopropyl)-6-[2-[3-(trifluoromethylsulfanyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC(SC(F)(F)F)=CC=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O OYKVFHYFGRQFRX-UHFFFAOYSA-N 0.000 claims description 4
- AQUCJPCZDSRMPR-UHFFFAOYSA-N 2-(1-phenylcyclopropyl)-6-[2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC=CC(C2=CC(OC(F)(F)F)=CC=C2)=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O AQUCJPCZDSRMPR-UHFFFAOYSA-N 0.000 claims description 4
- UHZBRISPMSTETG-UHFFFAOYSA-N 2-(1-phenylcyclopropyl)-6-[2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC=CC(C2=CC(C(F)(F)F)=CC=C2)=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O UHZBRISPMSTETG-UHFFFAOYSA-N 0.000 claims description 4
- UABNLOMPXLKGEW-UHFFFAOYSA-N 2-(1-phenylcyclopropyl)-6-[2-[3-[4-(trifluoromethoxy)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC=CC(C(C=C2)=CC=C2OC(F)(F)F)=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O UABNLOMPXLKGEW-UHFFFAOYSA-N 0.000 claims description 4
- UJYBSTJMANQXKI-UHFFFAOYSA-N 2-(1-phenylcyclopropyl)-6-[2-[3-[4-(trifluoromethyl)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC=CC(C2=CC=C(C(F)(F)F)C=C2)=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O UJYBSTJMANQXKI-UHFFFAOYSA-N 0.000 claims description 4
- QNKSMTACMYPQCC-UHFFFAOYSA-N 2-(1-phenylcyclopropyl)-8-[2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-5,6,7,9-tetrahydro-3H-pyrimido[4,5-c]azepin-4-one Chemical compound O=C(CC1=CC=CC(C2=CC(C(F)(F)F)=CC=C2)=C1)N(CCC1)CC(N=C(C2(CC2)C2=CC=CC=C2)N2)=C1C2=O QNKSMTACMYPQCC-UHFFFAOYSA-N 0.000 claims description 4
- CQGCANRCDBQMFE-OAQYLSRUSA-N 2-[1-(3-bromophenyl)cyclopropyl]-6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Br)=CC=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 CQGCANRCDBQMFE-OAQYLSRUSA-N 0.000 claims description 4
- AAPDFDCLHWMGKA-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-(2-naphthalen-1-ylacetyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC=CC2=CC=CC=C12)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O AAPDFDCLHWMGKA-UHFFFAOYSA-N 0.000 claims description 4
- NJTRZJHRETYRIA-OAQYLSRUSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-(2,3-difluorophenyl)-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C(C=CC=C1F)=C1F NJTRZJHRETYRIA-OAQYLSRUSA-N 0.000 claims description 4
- FBLPFOAVSDBKBY-OAQYLSRUSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 FBLPFOAVSDBKBY-OAQYLSRUSA-N 0.000 claims description 4
- NSHVQDPLYSHBAO-HHHXNRCGSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-[3-(2,2-difluoro-1,3-benzodioxol-5-yl)phenyl]-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC(C(C=C2)=CC(O3)=C2OC3(F)F)=CC=C1 NSHVQDPLYSHBAO-HHHXNRCGSA-N 0.000 claims description 4
- NJDZYFFQNSLISP-AREMUKBSSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-[3-(3-chlorophenyl)phenyl]-2-hydroxyacetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(Cl)=CC=C2)=C1 NJDZYFFQNSLISP-AREMUKBSSA-N 0.000 claims description 4
- KYSAHUAOOWJXCS-HHHXNRCGSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-[3-(3-chlorophenyl)phenyl]-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(Cl)=CC=C2)=C1 KYSAHUAOOWJXCS-HHHXNRCGSA-N 0.000 claims description 4
- VCTIJOPXJKFFJP-SSEXGKCCSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-[3-(3-cyclopropylphenyl)phenyl]-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(C3CC3)=CC=C2)=C1 VCTIJOPXJKFFJP-SSEXGKCCSA-N 0.000 claims description 4
- LZBYYBPWLLTMCC-HHHXNRCGSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-[3-(3-fluorophenyl)phenyl]-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(F)=CC=C2)=C1 LZBYYBPWLLTMCC-HHHXNRCGSA-N 0.000 claims description 4
- INUJSXZGAIMWEY-HHHXNRCGSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-[3-(4-chlorophenyl)phenyl]-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C(C=C2)=CC=C2Cl)=C1 INUJSXZGAIMWEY-HHHXNRCGSA-N 0.000 claims description 4
- MEUOFPNCRKKLKP-AREMUKBSSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-[3-[3-chloro-5-(trifluoromethoxy)phenyl]phenyl]-2-hydroxyacetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(Cl)=CC(OC(F)(F)F)=C2)=C1 MEUOFPNCRKKLKP-AREMUKBSSA-N 0.000 claims description 4
- ULEZILGXXDAQHB-HHHXNRCGSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-[3-[3-chloro-5-(trifluoromethoxy)phenyl]phenyl]-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(Cl)=CC(OC(F)(F)F)=C2)=C1 ULEZILGXXDAQHB-HHHXNRCGSA-N 0.000 claims description 4
- OZMBSEBDXXZBSN-AREMUKBSSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-[3-[3-chloro-5-(trifluoromethyl)phenyl]phenyl]-2-hydroxyacetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(Cl)=CC(C(F)(F)F)=C2)=C1 OZMBSEBDXXZBSN-AREMUKBSSA-N 0.000 claims description 4
- SOHBGNBLMPWIBG-HHHXNRCGSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-[3-[3-chloro-5-(trifluoromethyl)phenyl]phenyl]-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(Cl)=CC(C(F)(F)F)=C2)=C1 SOHBGNBLMPWIBG-HHHXNRCGSA-N 0.000 claims description 4
- NTXBNPIOJPVFFA-AREMUKBSSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-[3-[4-chloro-3-(trifluoromethyl)phenyl]phenyl]-2-hydroxyacetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C(C=C2)=CC(C(F)(F)F)=C2Cl)=C1 NTXBNPIOJPVFFA-AREMUKBSSA-N 0.000 claims description 4
- QYHQASFCCSNKHF-HHHXNRCGSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-[3-[4-chloro-3-(trifluoromethyl)phenyl]phenyl]-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C(C=C2)=CC(C(F)(F)F)=C2Cl)=C1 QYHQASFCCSNKHF-HHHXNRCGSA-N 0.000 claims description 4
- BBEKICSUUITYMF-UUWRZZSWSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(3-phenylmethoxyphenyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(OCC3=CC=CC=C3)=CC=C2)=C1 BBEKICSUUITYMF-UUWRZZSWSA-N 0.000 claims description 4
- JRGJJDUZYOGUHP-SSEXGKCCSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(3-propan-2-yloxyphenyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)OC1=CC=CC(C2=CC([C@H](C(N(CCC3)CC4=C3N=C(C3(CC3)C3=CC(Cl)=CC=C3)NC4=O)=O)O)=CC=C2)=C1 JRGJJDUZYOGUHP-SSEXGKCCSA-N 0.000 claims description 4
- GBPJQFUSOARMML-SSEXGKCCSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(3-propan-2-ylphenyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)C1=CC=CC(C2=CC([C@H](C(N(CCC3)CC4=C3N=C(C3(CC3)C3=CC(Cl)=CC=C3)NC4=O)=O)O)=CC=C2)=C1 GBPJQFUSOARMML-SSEXGKCCSA-N 0.000 claims description 4
- JOSZTOREWPGZKA-OAQYLSRUSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 JOSZTOREWPGZKA-OAQYLSRUSA-N 0.000 claims description 4
- MHPVJSICIQSBKM-AREMUKBSSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-[2-(trifluoromethyl)pyridin-4-yl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC(C2=CC(C(F)(F)F)=NC=C2)=CC=C1 MHPVJSICIQSBKM-AREMUKBSSA-N 0.000 claims description 4
- UUNLDHFPHOPTKJ-AREMUKBSSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(OC(F)(F)F)=CC=C2)=C1 UUNLDHFPHOPTKJ-AREMUKBSSA-N 0.000 claims description 4
- PNPWQKPAUGWDAM-HHHXNRCGSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(OC(F)(F)F)=CC=C2)=C1 PNPWQKPAUGWDAM-HHHXNRCGSA-N 0.000 claims description 4
- CYNHXFGXWMXNJC-AREMUKBSSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(C(F)(F)F)=CC=C2)=C1 CYNHXFGXWMXNJC-AREMUKBSSA-N 0.000 claims description 4
- QMBWVHCUTBDSKA-HHHXNRCGSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(C(F)(F)F)=CC=C2)=C1 QMBWVHCUTBDSKA-HHHXNRCGSA-N 0.000 claims description 4
- QTPHCHBNTYUSJF-HHHXNRCGSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-[4-(trifluoromethoxy)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C(C=C2)=CC=C2OC(F)(F)F)=C1 QTPHCHBNTYUSJF-HHHXNRCGSA-N 0.000 claims description 4
- CJHRSHGJGVPBJM-HHHXNRCGSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-[4-(trifluoromethyl)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC=C(C(F)(F)F)C=C2)=C1 CJHRSHGJGVPBJM-HHHXNRCGSA-N 0.000 claims description 4
- YLACUOPJBZILCK-RUZDIDTESA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-[6-(trifluoromethyl)pyridin-2-yl]phenyl]acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC(C2=NC(C(F)(F)F)=CC=C2)=CC=C1 YLACUOPJBZILCK-RUZDIDTESA-N 0.000 claims description 4
- UBFITHLNQWKDCY-MDZDMXLPSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[(E)-3-[3-(trifluoromethyl)phenyl]prop-2-enoyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(/C=C/C1=CC(C(F)(F)F)=CC=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O UBFITHLNQWKDCY-MDZDMXLPSA-N 0.000 claims description 4
- YJMQPIUXRRXKOC-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2,2-difluoro-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(C(C1=CC(C(F)(F)F)=CC=C1)(F)F)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O YJMQPIUXRRXKOC-UHFFFAOYSA-N 0.000 claims description 4
- QRAWIIUSTJYLNV-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-(2-phenoxyphenyl)acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC(C=CC=C1)=C1OC1=CC=CC=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O QRAWIIUSTJYLNV-UHFFFAOYSA-N 0.000 claims description 4
- OVWLGJMANAMWRR-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-(2-phenylmethoxyphenyl)acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC(C=CC=C1)=C1OCC1=CC=CC=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O OVWLGJMANAMWRR-UHFFFAOYSA-N 0.000 claims description 4
- NODDUIZJXSJVCN-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-(3-chlorophenyl)-2,2-difluoroacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(C(C1=CC(Cl)=CC=C1)(F)F)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O NODDUIZJXSJVCN-UHFFFAOYSA-N 0.000 claims description 4
- WOZUEPHEBQKYTN-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-(3-cyclopropylphenyl)-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound OC(C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC(C2CC2)=CC=C1 WOZUEPHEBQKYTN-UHFFFAOYSA-N 0.000 claims description 4
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- CICZSXNCQPSYSI-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-(3-phenylmethoxyphenyl)acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC(OCC2=CC=CC=C2)=CC=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O CICZSXNCQPSYSI-UHFFFAOYSA-N 0.000 claims description 4
- WOXBDAUWCPJEIG-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-(3-phenylphenyl)acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC=CC(C2=CC=CC=C2)=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O WOXBDAUWCPJEIG-UHFFFAOYSA-N 0.000 claims description 4
- ZOQXUYHHKHKABE-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-[2-fluoro-3-(trifluoromethyl)phenyl]-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound OC(C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C(C=CC=C1C(F)(F)F)=C1F ZOQXUYHHKHKABE-UHFFFAOYSA-N 0.000 claims description 4
- FGPIAFGCLVISBH-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-[2-fluoro-3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC(C=CC=C1C(F)(F)F)=C1F)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O FGPIAFGCLVISBH-UHFFFAOYSA-N 0.000 claims description 4
- KMEBPJJCIGVJLK-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-[3-(3-chlorophenyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC=CC(C2=CC(Cl)=CC=C2)=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O KMEBPJJCIGVJLK-UHFFFAOYSA-N 0.000 claims description 4
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- LAOFXCHGZHPUTD-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC(C(F)(F)F)=CC=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O LAOFXCHGZHPUTD-UHFFFAOYSA-N 0.000 claims description 4
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- WEJJPPHDSXCFBA-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-[3-(trifluoromethylsulfanyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC(SC(F)(F)F)=CC=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O WEJJPPHDSXCFBA-UHFFFAOYSA-N 0.000 claims description 4
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- WYLXRSGJQSUHSH-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-[3-[4-(trifluoromethoxy)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC=CC(C(C=C2)=CC=C2OC(F)(F)F)=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O WYLXRSGJQSUHSH-UHFFFAOYSA-N 0.000 claims description 4
- OIDMKSOWWKDHIT-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-[3-[4-(trifluoromethyl)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC=CC(C2=CC=C(C(F)(F)F)C=C2)=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O OIDMKSOWWKDHIT-UHFFFAOYSA-N 0.000 claims description 4
- VYKXWGFAGIIMJO-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-[3-[6-(trifluoromethyl)pyridin-2-yl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC(C2=NC(C(F)(F)F)=CC=C2)=CC=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O VYKXWGFAGIIMJO-UHFFFAOYSA-N 0.000 claims description 4
- RFULAZJMYOSEAB-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-hydroxy-2-(2-phenoxyphenyl)acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound OC(C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C(C=CC=C1)=C1OC1=CC=CC=C1 RFULAZJMYOSEAB-UHFFFAOYSA-N 0.000 claims description 4
- KOSNADVUBBMIEY-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-hydroxy-2-(3-phenoxyphenyl)acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound OC(C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC(OC2=CC=CC=C2)=CC=C1 KOSNADVUBBMIEY-UHFFFAOYSA-N 0.000 claims description 4
- KNXUAVLSQLJGIX-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-hydroxy-2-(3-phenylmethoxyphenyl)acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound OC(C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC(OCC2=CC=CC=C2)=CC=C1 KNXUAVLSQLJGIX-UHFFFAOYSA-N 0.000 claims description 4
- CHKMBGAIBASIQP-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-hydroxy-2-(3-phenylmethoxyphenyl)acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound OC(C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC(OCC2=CC=CC=C2)=CC=C1 CHKMBGAIBASIQP-UHFFFAOYSA-N 0.000 claims description 4
- HPHYKMQUGOBORN-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-hydroxy-2-(3-quinolin-3-ylphenyl)acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound OC(C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC(C2=CC3=CC=CC=C3N=C2)=CC=C1 HPHYKMQUGOBORN-UHFFFAOYSA-N 0.000 claims description 4
- SZEXGVWCOPLESU-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-hydroxy-2-(3-quinolin-3-ylphenyl)acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound OC(C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC(C2=CC3=CC=CC=C3N=C2)=CC=C1 SZEXGVWCOPLESU-UHFFFAOYSA-N 0.000 claims description 4
- BZRXPKAJXFAFBD-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-hydroxy-2-[3-(trifluoromethylsulfanyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound OC(C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC(SC(F)(F)F)=CC=C1 BZRXPKAJXFAFBD-UHFFFAOYSA-N 0.000 claims description 4
- UUNLDHFPHOPTKJ-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-hydroxy-2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound OC(C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(OC(F)(F)F)=CC=C2)=C1 UUNLDHFPHOPTKJ-UHFFFAOYSA-N 0.000 claims description 4
- PNPWQKPAUGWDAM-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-hydroxy-2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound OC(C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(OC(F)(F)F)=CC=C2)=C1 PNPWQKPAUGWDAM-UHFFFAOYSA-N 0.000 claims description 4
- UTWKDQPGRVHKDN-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-hydroxy-2-[3-[3-(trifluoromethyl)phenoxy]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound OC(C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC(OC2=CC(C(F)(F)F)=CC=C2)=CC=C1 UTWKDQPGRVHKDN-UHFFFAOYSA-N 0.000 claims description 4
- CYNHXFGXWMXNJC-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-hydroxy-2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound OC(C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(C(F)(F)F)=CC=C2)=C1 CYNHXFGXWMXNJC-UHFFFAOYSA-N 0.000 claims description 4
- QMBWVHCUTBDSKA-UHFFFAOYSA-N 2-[1-(3-chlorophenyl)cyclopropyl]-6-[2-hydroxy-2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound OC(C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(C(F)(F)F)=CC=C2)=C1 QMBWVHCUTBDSKA-UHFFFAOYSA-N 0.000 claims description 4
- OORNKWZKZKKMGC-MGBGTMOVSA-N 2-[1-(3-cyclohexylphenyl)cyclopropyl]-6-[(2R)-2-[3-(3-fluorophenyl)phenyl]-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(F)=CC=C2)=C1 OORNKWZKZKKMGC-MGBGTMOVSA-N 0.000 claims description 4
- ZVUBEHXPWJKYAP-HHHXNRCGSA-N 2-[1-(3-cyclohexylphenyl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 ZVUBEHXPWJKYAP-HHHXNRCGSA-N 0.000 claims description 4
- DDJPWVCWESYQTC-MGBGTMOVSA-N 2-[1-(3-cyclohexylphenyl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(OC(F)(F)F)=CC=C2)=C1 DDJPWVCWESYQTC-MGBGTMOVSA-N 0.000 claims description 4
- XEZTZUUIANEZSR-MGBGTMOVSA-N 2-[1-(3-cyclohexylphenyl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(C(F)(F)F)=CC=C2)=C1 XEZTZUUIANEZSR-MGBGTMOVSA-N 0.000 claims description 4
- XWAFZLLVZGYYPM-UHFFFAOYSA-N 2-[1-(3-cyclohexylphenyl)cyclopropyl]-6-[2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O=C(CC1=CC=CC(C2=CC(C(F)(F)F)=CC=C2)=C1)N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CC=C1)NC2=O XWAFZLLVZGYYPM-UHFFFAOYSA-N 0.000 claims description 4
- AEIYGOSOACTWQX-UHFFFAOYSA-N 2-[1-(3-cyclohexylphenyl)cyclopropyl]-6-[2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC=CC(C2=CC(C(F)(F)F)=CC=C2)=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CC=C1)NC2=O AEIYGOSOACTWQX-UHFFFAOYSA-N 0.000 claims description 4
- HROKYRSAHQPONC-RUZDIDTESA-N 2-[1-(3-cyclopentylphenyl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCC3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 HROKYRSAHQPONC-RUZDIDTESA-N 0.000 claims description 4
- NSKOKAIUNCGPRA-AREMUKBSSA-N 2-[1-(3-cyclopentylphenyl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCC3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 NSKOKAIUNCGPRA-AREMUKBSSA-N 0.000 claims description 4
- NTSXNCNVWDTTQK-OAQYLSRUSA-N 2-[1-(3-fluorophenyl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(F)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 NTSXNCNVWDTTQK-OAQYLSRUSA-N 0.000 claims description 4
- OSNCAJPSCJZMMA-UHFFFAOYSA-N 2-[1-(3-fluorophenyl)cyclopropyl]-6-[2-[2-fluoro-3-(trifluoromethyl)phenyl]-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound OC(C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(F)=CC=C1)NC2=O)=O)C(C=CC=C1C(F)(F)F)=C1F OSNCAJPSCJZMMA-UHFFFAOYSA-N 0.000 claims description 4
- KUKAIFLTSWBCPY-UHFFFAOYSA-N 2-[1-(3-fluorophenyl)cyclopropyl]-6-[2-[3-(trifluoromethyl)phenyl]propanoyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(F)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 KUKAIFLTSWBCPY-UHFFFAOYSA-N 0.000 claims description 4
- ZFNYIFINSDNESK-UHFFFAOYSA-N 2-[1-(3-fluorophenyl)cyclopropyl]-6-[2-hydroxy-2-[3-(trifluoromethylsulfanyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound OC(C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(F)=CC=C1)NC2=O)=O)C1=CC(SC(F)(F)F)=CC=C1 ZFNYIFINSDNESK-UHFFFAOYSA-N 0.000 claims description 4
- CUIIJHGGONWFMB-UHFFFAOYSA-N 2-[1-(3-fluorophenyl)cyclopropyl]-6-[2-hydroxy-2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound OC(C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(F)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(OC(F)(F)F)=CC=C2)=C1 CUIIJHGGONWFMB-UHFFFAOYSA-N 0.000 claims description 4
- UJWRQSJBUUHUAT-UHFFFAOYSA-N 2-[1-(3-fluorophenyl)cyclopropyl]-6-[2-hydroxy-2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound OC(C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(F)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(OC(F)(F)F)=CC=C2)=C1 UJWRQSJBUUHUAT-UHFFFAOYSA-N 0.000 claims description 4
- XQANYFIVTQHLTA-UHFFFAOYSA-N 2-[1-(3-fluorophenyl)cyclopropyl]-6-[2-hydroxy-2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound OC(C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(F)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(C(F)(F)F)=CC=C2)=C1 XQANYFIVTQHLTA-UHFFFAOYSA-N 0.000 claims description 4
- SJNMQBBIIRWVOJ-UHFFFAOYSA-N 2-[1-(3-fluorophenyl)cyclopropyl]-6-[2-hydroxy-2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound OC(C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(F)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(C(F)(F)F)=CC=C2)=C1 SJNMQBBIIRWVOJ-UHFFFAOYSA-N 0.000 claims description 4
- HNUBFUDTVUKXOH-UHFFFAOYSA-N 2-[1-(3-propan-2-ylphenyl)cyclopropyl]-6-[2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound CC(C)C1=CC=CC(C2(CC2)C(N2)=NC(CCN(C3)C(CC4=CC=CC(C5=CC(C(F)(F)F)=CC=C5)=C4)=O)=C3C2=O)=C1 HNUBFUDTVUKXOH-UHFFFAOYSA-N 0.000 claims description 4
- YONPADCTXLDACV-UHFFFAOYSA-N 2-[1-(3-propan-2-ylphenyl)cyclopropyl]-6-[2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C(CC4=CC=CC(C5=CC(C(F)(F)F)=CC=C5)=C4)=O)=C3C2=O)=C1 YONPADCTXLDACV-UHFFFAOYSA-N 0.000 claims description 4
- JGQBUZLFFBBJCD-GOSISDBHSA-N 2-[1-(4-bromothiophen-2-yl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(Br)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 JGQBUZLFFBBJCD-GOSISDBHSA-N 0.000 claims description 4
- YQCSLYIEBOBXTH-LJQANCHMSA-N 2-[1-(4-bromothiophen-2-yl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Br)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 YQCSLYIEBOBXTH-LJQANCHMSA-N 0.000 claims description 4
- HNOGJYMRIQZDAO-RUZDIDTESA-N 2-[1-(4-cycloheptylthiophen-2-yl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCCC3)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 HNOGJYMRIQZDAO-RUZDIDTESA-N 0.000 claims description 4
- STKBLZISGMDSCG-XMMPIXPASA-N 2-[1-(4-cyclohexylthiophen-2-yl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 STKBLZISGMDSCG-XMMPIXPASA-N 0.000 claims description 4
- UIKJKIIPXSWRTF-RUZDIDTESA-N 2-[1-(4-cyclohexylthiophen-2-yl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 UIKJKIIPXSWRTF-RUZDIDTESA-N 0.000 claims description 4
- LDFCUIIMPZHYKM-WJOKGBTCSA-N 2-[1-(4-cyclohexylthiophen-2-yl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CS1)NC2=O)=O)C1=CC=CC(C2=CC(OC(F)(F)F)=CC=C2)=C1 LDFCUIIMPZHYKM-WJOKGBTCSA-N 0.000 claims description 4
- INNBRMHUNCRLEU-WJOKGBTCSA-N 2-[1-(4-cyclohexylthiophen-2-yl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CS1)NC2=O)=O)C1=CC=CC(C2=CC(C(F)(F)F)=CC=C2)=C1 INNBRMHUNCRLEU-WJOKGBTCSA-N 0.000 claims description 4
- VHPXBGMNQCNMIP-HSZRJFAPSA-N 2-[1-(4-cyclopentylthiophen-2-yl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCC3)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 VHPXBGMNQCNMIP-HSZRJFAPSA-N 0.000 claims description 4
- MAQNDAIDDBJROP-XMMPIXPASA-N 2-[1-(4-cyclopentylthiophen-2-yl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCC3)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 MAQNDAIDDBJROP-XMMPIXPASA-N 0.000 claims description 4
- PZJAOLZVIZJOMY-HXUWFJFHSA-N 2-[1-(4-ethylthiophen-2-yl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound CCC1=CSC(C2(CC2)C(N2)=NC(CCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 PZJAOLZVIZJOMY-HXUWFJFHSA-N 0.000 claims description 4
- DQHSIXICEPJGHE-OAQYLSRUSA-N 2-[1-(4-ethylthiophen-2-yl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CCC1=CSC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 DQHSIXICEPJGHE-OAQYLSRUSA-N 0.000 claims description 4
- RHYPEJZJBZHGAB-UHFFFAOYSA-N 2-[1-(4-phenylthiophen-2-yl)cyclopropyl]-6-[2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC=CC(C2=CC(C(F)(F)F)=CC=C2)=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=CC=C3)=CS1)NC2=O RHYPEJZJBZHGAB-UHFFFAOYSA-N 0.000 claims description 4
- QANRZYNMEANWPK-UHFFFAOYSA-N 2-[1-(4-propan-2-ylthiophen-2-yl)cyclopropyl]-6-[2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)C1=CSC(C2(CC2)C(N2)=NC(CCCN(C3)C(CC4=CC=CC(C5=CC(C(F)(F)F)=CC=C5)=C4)=O)=C3C2=O)=C1 QANRZYNMEANWPK-UHFFFAOYSA-N 0.000 claims description 4
- CZFFMCSMSPEGSX-JGCGQSQUSA-N 2-[1-(5-cyclohexylpyridin-3-yl)cyclopropyl]-6-[(2R)-2-[3-(3-fluorophenyl)phenyl]-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CN=C1)NC2=O)=O)C1=CC=CC(C2=CC(F)=CC=C2)=C1 CZFFMCSMSPEGSX-JGCGQSQUSA-N 0.000 claims description 4
- QZNZKIJPPMIDPR-RUZDIDTESA-N 2-[1-(5-cyclohexylpyridin-3-yl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CN=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 QZNZKIJPPMIDPR-RUZDIDTESA-N 0.000 claims description 4
- BTHSHBBGAPSHMR-AREMUKBSSA-N 2-[1-(5-cyclohexylpyridin-3-yl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CN=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 BTHSHBBGAPSHMR-AREMUKBSSA-N 0.000 claims description 4
- ZSWMXBPUXOYRJN-JGCGQSQUSA-N 2-[1-(5-cyclohexylpyridin-3-yl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CN=C1)NC2=O)=O)C1=CC=CC(C2=CC(OC(F)(F)F)=CC=C2)=C1 ZSWMXBPUXOYRJN-JGCGQSQUSA-N 0.000 claims description 4
- UPXSZYRDQDAPHS-JGCGQSQUSA-N 2-[1-(5-cyclohexylpyridin-3-yl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CN=C1)NC2=O)=O)C1=CC=CC(C2=CC(C(F)(F)F)=CC=C2)=C1 UPXSZYRDQDAPHS-JGCGQSQUSA-N 0.000 claims description 4
- TYVKQIMUMPLGRC-XMMPIXPASA-N 2-[1-(5-cyclopentylpyridin-3-yl)cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCC3)=CN=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 TYVKQIMUMPLGRC-XMMPIXPASA-N 0.000 claims description 4
- LFTVOIFAGMHXRA-UHFFFAOYSA-N 2-[1-(5-phenylpyridin-3-yl)cyclopropyl]-6-[2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC=CC(C2=CC(C(F)(F)F)=CC=C2)=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=CC=C3)=CN=C1)NC2=O LFTVOIFAGMHXRA-UHFFFAOYSA-N 0.000 claims description 4
- NCJIUWMHAIVXFG-HHHXNRCGSA-N 2-[1-[3-(1,3-benzothiazol-2-yl)phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=NC(C=CC=C4)=C4S3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 NCJIUWMHAIVXFG-HHHXNRCGSA-N 0.000 claims description 4
- FNBPFLRSGNKIAT-MUUNZHRXSA-N 2-[1-[3-(1,3-benzothiazol-6-yl)phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C(C=C3)=CC4=C3N=CS4)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 FNBPFLRSGNKIAT-MUUNZHRXSA-N 0.000 claims description 4
- BVMVJRPDZQPSRE-GDLZYMKVSA-N 2-[1-[3-(1-benzofuran-2-yl)phenyl]cyclopropyl]-6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC(C=CC=C4)=C4O3)=CC=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 BVMVJRPDZQPSRE-GDLZYMKVSA-N 0.000 claims description 4
- MBTAGZVBGASURJ-GDLZYMKVSA-N 2-[1-[3-(1-benzofuran-3-yl)phenyl]cyclopropyl]-6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=COC4=C3C=CC=C4)=CC=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 MBTAGZVBGASURJ-GDLZYMKVSA-N 0.000 claims description 4
- AWJHOCKSCYIRDZ-GDLZYMKVSA-N 2-[1-[3-(1-benzothiophen-2-yl)phenyl]cyclopropyl]-6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC(C=CC=C4)=C4S3)=CC=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 AWJHOCKSCYIRDZ-GDLZYMKVSA-N 0.000 claims description 4
- DKTGIXZQCOGVTK-GDLZYMKVSA-N 2-[1-[3-(1-benzothiophen-2-yl)phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC(C=CC=C4)=C4S3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 DKTGIXZQCOGVTK-GDLZYMKVSA-N 0.000 claims description 4
- WKYHARYLICAVIX-GDLZYMKVSA-N 2-[1-[3-(1-benzothiophen-3-yl)phenyl]cyclopropyl]-6-[(2R)-2-(3-bromophenyl)-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CSC4=C3C=CC=C4)=CC=C1)NC2=O)=O)C1=CC(Br)=CC=C1 WKYHARYLICAVIX-GDLZYMKVSA-N 0.000 claims description 4
- HLMFWAHVRGFCLX-GDLZYMKVSA-N 2-[1-[3-(1-benzothiophen-3-yl)phenyl]cyclopropyl]-6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CSC4=C3C=CC=C4)=CC=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 HLMFWAHVRGFCLX-GDLZYMKVSA-N 0.000 claims description 4
- BEIOYZWNLKZGPX-PGUFJCEWSA-N 2-[1-[3-(1-benzothiophen-3-yl)phenyl]cyclopropyl]-6-[(2R)-2-[3-(3-chloro-5-fluorophenyl)phenyl]-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CSC4=C3C=CC=C4)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(Cl)=CC(F)=C2)=C1 BEIOYZWNLKZGPX-PGUFJCEWSA-N 0.000 claims description 4
- WSIMDFVJHLGQET-PGUFJCEWSA-N 2-[1-[3-(1-benzothiophen-3-yl)phenyl]cyclopropyl]-6-[(2R)-2-[3-(3-chlorophenyl)phenyl]-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CSC4=C3C=CC=C4)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(Cl)=CC=C2)=C1 WSIMDFVJHLGQET-PGUFJCEWSA-N 0.000 claims description 4
- VVTIJYCCYZXGAH-KXQOOQHDSA-N 2-[1-[3-(1-benzothiophen-3-yl)phenyl]cyclopropyl]-6-[(2R)-2-[3-(3-cyclopropylphenyl)phenyl]-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CSC4=C3C=CC=C4)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(C3CC3)=CC=C2)=C1 VVTIJYCCYZXGAH-KXQOOQHDSA-N 0.000 claims description 4
- MSUNLGFKPXORHN-KXQOOQHDSA-N 2-[1-[3-(1-benzothiophen-3-yl)phenyl]cyclopropyl]-6-[(2R)-2-[3-(3-tert-butylphenyl)phenyl]-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)(C)C1=CC=CC(C2=CC([C@H](C(N(CCC3)CC4=C3N=C(C3(CC3)C3=CC(C5=CSC6=C5C=CC=C6)=CC=C3)NC4=O)=O)O)=CC=C2)=C1 MSUNLGFKPXORHN-KXQOOQHDSA-N 0.000 claims description 4
- GJNIYWBEMRTSSH-KXQOOQHDSA-N 2-[1-[3-(1-benzothiophen-3-yl)phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(3-propan-2-ylphenyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)C1=CC=CC(C2=CC([C@H](C(N(CCC3)CC4=C3N=C(C3(CC3)C3=CC(C5=CSC6=C5C=CC=C6)=CC=C3)NC4=O)=O)O)=CC=C2)=C1 GJNIYWBEMRTSSH-KXQOOQHDSA-N 0.000 claims description 4
- IJYUPHWHZCMEHL-GDLZYMKVSA-N 2-[1-[3-(1-benzothiophen-3-yl)phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CSC4=C3C=CC=C4)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 IJYUPHWHZCMEHL-GDLZYMKVSA-N 0.000 claims description 4
- FHQFRDNKQJNRGO-PGUFJCEWSA-N 2-[1-[3-(1-benzothiophen-3-yl)phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CSC4=C3C=CC=C4)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(OC(F)(F)F)=CC=C2)=C1 FHQFRDNKQJNRGO-PGUFJCEWSA-N 0.000 claims description 4
- WQSZZVCGRAQDBY-PGUFJCEWSA-N 2-[1-[3-(1-benzothiophen-3-yl)phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CSC4=C3C=CC=C4)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(C(F)(F)F)=CC=C2)=C1 WQSZZVCGRAQDBY-PGUFJCEWSA-N 0.000 claims description 4
- OJEUEFNQOVSLLJ-UHFFFAOYSA-N 2-[1-[3-(1-benzothiophen-3-yl)phenyl]cyclopropyl]-6-[2,2-difluoro-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(C(C1=CC(C(F)(F)F)=CC=C1)(F)F)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CSC4=C3C=CC=C4)=CC=C1)NC2=O OJEUEFNQOVSLLJ-UHFFFAOYSA-N 0.000 claims description 4
- ZCMQONAGOLFTJL-UHFFFAOYSA-N 2-[1-[3-(1-benzothiophen-3-yl)phenyl]cyclopropyl]-6-[2-[3-(3-chlorophenyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC=CC(C2=CC(Cl)=CC=C2)=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CSC4=C3C=CC=C4)=CC=C1)NC2=O ZCMQONAGOLFTJL-UHFFFAOYSA-N 0.000 claims description 4
- QXTLDKHQWQGZKP-UHFFFAOYSA-N 2-[1-[3-(1-benzothiophen-3-yl)phenyl]cyclopropyl]-6-[2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC=CC(C2=CC(C(F)(F)F)=CC=C2)=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CSC4=C3C=CC=C4)=CC=C1)NC2=O QXTLDKHQWQGZKP-UHFFFAOYSA-N 0.000 claims description 4
- DOJRVOVIZYVDAF-GDLZYMKVSA-N 2-[1-[3-(1-benzothiophen-5-yl)phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C(C=C3)=CC4=C3SC=C4)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 DOJRVOVIZYVDAF-GDLZYMKVSA-N 0.000 claims description 4
- YIBPPTMVWYLACI-JGCGQSQUSA-N 2-[1-[3-(1-benzoylpiperidin-4-yl)phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C(CC3)CCN3C(C3=CC=CC=C3)=O)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 YIBPPTMVWYLACI-JGCGQSQUSA-N 0.000 claims description 4
- MPCAKBIKXWLOCG-MGBGTMOVSA-N 2-[1-[3-(1-benzylsulfonyl-3,6-dihydro-2H-pyridin-4-yl)phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C(CC3)=CCN3S(CC3=CC=CC=C3)(=O)=O)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 MPCAKBIKXWLOCG-MGBGTMOVSA-N 0.000 claims description 4
- LYQQNWYVZUEFRE-MUUNZHRXSA-N 2-[1-[3-(1-cyclobutylpyrazol-4-yl)phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CN(C4CCC4)N=C3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 LYQQNWYVZUEFRE-MUUNZHRXSA-N 0.000 claims description 4
- ZRDPDCFFZFGCAO-JGCGQSQUSA-N 2-[1-[3-(1-cyclohexylsulfonyl-3,6-dihydro-2H-pyridin-4-yl)phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C(CC3)=CCN3S(C3CCCCC3)(=O)=O)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 ZRDPDCFFZFGCAO-JGCGQSQUSA-N 0.000 claims description 4
- WXNANCJWMFKDFV-HHHXNRCGSA-N 2-[1-[3-(1-cyclopropylpyrazol-4-yl)phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CN(C4CC4)N=C3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 WXNANCJWMFKDFV-HHHXNRCGSA-N 0.000 claims description 4
- OUEPQOFSJUBWRG-HHHXNRCGSA-N 2-[1-[3-(2-fluorophenyl)phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C(C=CC=C3)=C3F)=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 OUEPQOFSJUBWRG-HHHXNRCGSA-N 0.000 claims description 4
- ROGQYGYFNWTAFC-HHHXNRCGSA-N 2-[1-[3-(3,4-difluorophenyl)phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C(C=C3)=CC(F)=C3F)=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 ROGQYGYFNWTAFC-HHHXNRCGSA-N 0.000 claims description 4
- PRLVLEBUAZRFAM-HHHXNRCGSA-N 2-[1-[3-(3,5-difluorophenyl)phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C3=CC(F)=CC(F)=C3)=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 PRLVLEBUAZRFAM-HHHXNRCGSA-N 0.000 claims description 4
- IPDLUJGIRIBPSS-HHHXNRCGSA-N 2-[1-[3-(3-fluorophenyl)phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C3=CC(F)=CC=C3)=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 IPDLUJGIRIBPSS-HHHXNRCGSA-N 0.000 claims description 4
- KALVDAOQHMNZIQ-AREMUKBSSA-N 2-[1-[3-(4,4-difluorocyclohexyl)phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C(CC3)CCC3(F)F)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 KALVDAOQHMNZIQ-AREMUKBSSA-N 0.000 claims description 4
- PKNWIMFQXTZBOX-MUUNZHRXSA-N 2-[1-[3-(4,4-dimethylcyclohexyl)phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)(CC1)CCC1C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 PKNWIMFQXTZBOX-MUUNZHRXSA-N 0.000 claims description 4
- ZZRTVVBQWRIVBM-HHHXNRCGSA-N 2-[1-[3-(4-fluorophenyl)phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C(C=C3)=CC=C3F)=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 ZZRTVVBQWRIVBM-HHHXNRCGSA-N 0.000 claims description 4
- JZSJJZISXIABCG-SSEXGKCCSA-N 2-[1-[3-(4-tert-butylphenyl)phenyl]cyclopropyl]-6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)(C)C(C=C1)=CC=C1C1=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(Cl)=CC=C4)O)=O)=C3C2=O)=CC=C1 JZSJJZISXIABCG-SSEXGKCCSA-N 0.000 claims description 4
- UNTKZSDCVIMZCG-UHFFFAOYSA-N 2-[1-[3-(cyclohexen-1-yl)phenyl]cyclopropyl]-6-[2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(CC1=CC=CC(C2=CC(C(F)(F)F)=CC=C2)=C1)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C3=CCCCC3)=C1)NC2=O UNTKZSDCVIMZCG-UHFFFAOYSA-N 0.000 claims description 4
- FHIMYKZTODHUAD-WJOKGBTCSA-N 2-[1-[3-[1-(3,3-dimethylbutanoyl)piperidin-4-yl]phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)(C)CC(N(CC1)CCC1C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1)=O FHIMYKZTODHUAD-WJOKGBTCSA-N 0.000 claims description 4
- FDCIIXAKNGIOBS-JGCGQSQUSA-N 2-[1-[3-[1-(4-fluorophenyl)sulfonyl-3,6-dihydro-2H-pyridin-4-yl]phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C(CC3)=CCN3S(C(C=C3)=CC=C3F)(=O)=O)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 FDCIIXAKNGIOBS-JGCGQSQUSA-N 0.000 claims description 4
- AYXJZTCMJMJKRO-XMMPIXPASA-N 2-[1-[3-[1-(difluoromethyl)pyrazol-4-yl]phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CN(C(F)F)N=C3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 AYXJZTCMJMJKRO-XMMPIXPASA-N 0.000 claims description 4
- OAMSYYDQVLCVGU-PSXMRANNSA-N 2-[1-[3-[1-[2-(2,3-dihydroindol-1-yl)acetyl]-3,6-dihydro-2H-pyridin-4-yl]phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C(CC3)=CCN3C(CN3C4=CC=CC=C4CC3)=O)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 OAMSYYDQVLCVGU-PSXMRANNSA-N 0.000 claims description 4
- QFASKSWIQMRQRK-WJOKGBTCSA-N 2-[1-[3-[4-(4-hydroxyoxan-4-yl)phenyl]phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C3=CC=C(C4(CCOCC4)O)C=C3)=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 QFASKSWIQMRQRK-WJOKGBTCSA-N 0.000 claims description 4
- JKXNMGISIRNGMI-GDLZYMKVSA-N 2-[1-[3-[4-(dimethylamino)phenyl]phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CN(C)C(C=C1)=CC=C1C1=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=CC=C1 JKXNMGISIRNGMI-GDLZYMKVSA-N 0.000 claims description 4
- JNSQLEMFSVAAEQ-DIPNUNPCSA-N 2-[1-[3-[4-[(5-chloro-3,4-dihydro-1H-isoquinolin-2-yl)methyl]phenyl]phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C3=CC=C(CN4CC5=CC=CC(Cl)=C5CC4)C=C3)=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 JNSQLEMFSVAAEQ-DIPNUNPCSA-N 0.000 claims description 4
- RWSQZGZIZWPADS-MUUNZHRXSA-N 2-[1-[3-[6-(dimethylamino)pyridin-3-yl]phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CN(C)C(N=C1)=CC=C1C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 RWSQZGZIZWPADS-MUUNZHRXSA-N 0.000 claims description 4
- CIORUIUXIPCRDO-PGUFJCEWSA-N 2-[1-[3-[6-[4-(3,3-dimethylbutanoyl)piperazin-1-yl]pyridin-3-yl]phenyl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)(C)CC(N(CC1)CCN1C(N=C1)=CC=C1C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1)=O CIORUIUXIPCRDO-PGUFJCEWSA-N 0.000 claims description 4
- BMZUPZGLKVAKFQ-XMMPIXPASA-N 2-[1-[4-(2-cyclopropylethyl)thiophen-2-yl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(CCC3CC3)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 BMZUPZGLKVAKFQ-XMMPIXPASA-N 0.000 claims description 4
- RLERBYPCHJWKGT-XMMPIXPASA-N 2-[1-[4-(3,3-dimethylbutyl)thiophen-2-yl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)(C)CCC1=CSC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 RLERBYPCHJWKGT-XMMPIXPASA-N 0.000 claims description 4
- AKKXKIVTTDPMTC-HSZRJFAPSA-N 2-[1-[4-(4,4-difluorocyclohexyl)thiophen-2-yl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C(CC3)CCC3(F)F)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 AKKXKIVTTDPMTC-HSZRJFAPSA-N 0.000 claims description 4
- GRZWESKVWRHXFV-XMMPIXPASA-N 2-[1-[4-(4,4-difluorocyclohexyl)thiophen-2-yl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C(CC3)CCC3(F)F)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 GRZWESKVWRHXFV-XMMPIXPASA-N 0.000 claims description 4
- QBVTWIGPFQOEJN-AREMUKBSSA-N 2-[1-[4-[2-(1-hydroxycyclohexyl)ethyl]thiophen-2-yl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(CCC3(CCCCC3)O)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 QBVTWIGPFQOEJN-AREMUKBSSA-N 0.000 claims description 4
- NGSGWHNYNMHRER-XMMPIXPASA-N 2-[1-[5-(4,4-difluorocyclohexyl)pyridin-3-yl]cyclopropyl]-6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C(CC3)CCC3(F)F)=CN=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 NGSGWHNYNMHRER-XMMPIXPASA-N 0.000 claims description 4
- IEFSONLKXDFQCS-MUUNZHRXSA-N 2-[3-[1-[6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-2-yl]cyclopropyl]phenyl]benzonitrile Chemical compound N#CC1=CC=CC=C1C1=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=CC=C1 IEFSONLKXDFQCS-MUUNZHRXSA-N 0.000 claims description 4
- WUTQBPXIOLZSDL-UHFFFAOYSA-N 2-fluoro-3-[1-hydroxy-2-oxo-2-[4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6-yl]ethyl]benzonitrile Chemical compound N#CC(C=CC=C1C(C(N(CC2)CC3=C2N=C(C2(CC2)C2=CC=CC=C2)NC3=O)=O)O)=C1F WUTQBPXIOLZSDL-UHFFFAOYSA-N 0.000 claims description 4
- DDHJSNLCCPTQRT-MUUNZHRXSA-N 2-fluoro-4-[3-[1-[6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-2-yl]cyclopropyl]phenyl]benzonitrile Chemical compound N#CC(C=CC(C1=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=CC=C1)=C1)=C1F DDHJSNLCCPTQRT-MUUNZHRXSA-N 0.000 claims description 4
- HQLFMZBPQHLKDI-MUUNZHRXSA-N 2-fluoro-5-[3-[1-[6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-2-yl]cyclopropyl]phenyl]benzonitrile Chemical compound N#CC(C=C(C=C1)C2=CC(C3(CC3)C(N3)=NC(CCCN(C4)C([C@@H](C5=CC(C(F)(F)F)=CC=C5)O)=O)=C4C3=O)=CC=C2)=C1F HQLFMZBPQHLKDI-MUUNZHRXSA-N 0.000 claims description 4
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims description 4
- FUCYFMBBQFYJPC-MUUNZHRXSA-N 3-[3-[(1R)-2-[2-[1-(3-chlorophenyl)cyclopropyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-6-yl]-1-hydroxy-2-oxoethyl]phenyl]benzonitrile Chemical compound N#CC1=CC=CC(C2=CC([C@H](C(N(CCC3)CC4=C3N=C(C3(CC3)C3=CC(Cl)=CC=C3)NC4=O)=O)O)=CC=C2)=C1 FUCYFMBBQFYJPC-MUUNZHRXSA-N 0.000 claims description 4
- AUURQCXJBYKRQX-MUUNZHRXSA-N 3-[3-[1-[6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-2-yl]cyclopropyl]phenyl]benzonitrile Chemical compound N#CC1=CC=CC(C2=CC(C3(CC3)C(N3)=NC(CCCN(C4)C([C@@H](C5=CC(Cl)=CC=C5)O)=O)=C4C3=O)=CC=C2)=C1 AUURQCXJBYKRQX-MUUNZHRXSA-N 0.000 claims description 4
- WDLJLRYXOGGANF-GDLZYMKVSA-N 3-[3-[1-[6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-2-yl]cyclopropyl]phenyl]-N,N-dimethylbenzamide Chemical compound CN(C)C(C1=CC=CC(C2=CC(C3(CC3)C(N3)=NC(CCCN(C4)C([C@@H](C5=CC(C(F)(F)F)=CC=C5)O)=O)=C4C3=O)=CC=C2)=C1)=O WDLJLRYXOGGANF-GDLZYMKVSA-N 0.000 claims description 4
- VLRYMFWRLJLDIY-MUUNZHRXSA-N 3-[3-[1-[6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-2-yl]cyclopropyl]phenyl]benzonitrile Chemical compound N#CC1=CC=CC(C2=CC(C3(CC3)C(N3)=NC(CCCN(C4)C([C@@H](C5=CC(C(F)(F)F)=CC=C5)O)=O)=C4C3=O)=CC=C2)=C1 VLRYMFWRLJLDIY-MUUNZHRXSA-N 0.000 claims description 4
- DZNQUXOSVFYIQQ-HHHXNRCGSA-N 3-chloro-5-[3-[(1R)-1-hydroxy-2-oxo-2-[4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6-yl]ethyl]phenyl]benzonitrile Chemical compound N#CC1=CC(Cl)=CC(C2=CC([C@H](C(N(CC3)CC4=C3N=C(C3(CC3)C3=CC=CC=C3)NC4=O)=O)O)=CC=C2)=C1 DZNQUXOSVFYIQQ-HHHXNRCGSA-N 0.000 claims description 4
- MTCGTOGIAJBHIF-MUUNZHRXSA-N 3-chloro-5-[3-[(1R)-1-hydroxy-2-oxo-2-[4-oxo-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-6-yl]ethyl]phenyl]benzonitrile Chemical compound N#CC1=CC(Cl)=CC(C2=CC([C@H](C(N(CCC3)CC4=C3N=C(C3(CC3)C3=CC=CC=C3)NC4=O)=O)O)=CC=C2)=C1 MTCGTOGIAJBHIF-MUUNZHRXSA-N 0.000 claims description 4
- NEKNEJKPNKXCTR-HHHXNRCGSA-N 3-chloro-5-[3-[(1R)-2-[2-[1-(3-chlorophenyl)cyclopropyl]-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6-yl]-1-hydroxy-2-oxoethyl]phenyl]benzonitrile Chemical compound N#CC1=CC(Cl)=CC(C2=CC([C@H](C(N(CC3)CC4=C3N=C(C3(CC3)C3=CC(Cl)=CC=C3)NC4=O)=O)O)=CC=C2)=C1 NEKNEJKPNKXCTR-HHHXNRCGSA-N 0.000 claims description 4
- VWNMAYJENKHWKK-UHFFFAOYSA-N 3-chloro-5-[3-[2-[2-[1-(3-chlorophenyl)cyclopropyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-6-yl]-2-oxoethyl]phenyl]benzonitrile Chemical compound N#CC1=CC(Cl)=CC(C2=CC(CC(N(CCC3)CC4=C3N=C(C3(CC3)C3=CC(Cl)=CC=C3)NC4=O)=O)=CC=C2)=C1 VWNMAYJENKHWKK-UHFFFAOYSA-N 0.000 claims description 4
- ODRDHZDHXYIXEC-UHFFFAOYSA-N 3-chloro-5-[3-[2-oxo-2-[4-oxo-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-6-yl]ethyl]phenyl]benzonitrile Chemical compound N#CC1=CC(Cl)=CC(C2=CC(CC(N(CCC3)CC4=C3N=C(C3(CC3)C3=CC=CC=C3)NC4=O)=O)=CC=C2)=C1 ODRDHZDHXYIXEC-UHFFFAOYSA-N 0.000 claims description 4
- UYQFQEVRXTYJPR-PGUFJCEWSA-N 3-cyclohexyl-1-[[4-[3-[1-[6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-2-yl]cyclopropyl]phenyl]phenyl]methyl]-1-methylurea Chemical compound CN(CC(C=C1)=CC=C1C1=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=CC=C1)C(NC1CCCCC1)=O UYQFQEVRXTYJPR-PGUFJCEWSA-N 0.000 claims description 4
- NYFXQIUHGAINAB-MUUNZHRXSA-N 3-fluoro-5-[3-[1-[6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-2-yl]cyclopropyl]phenyl]benzonitrile Chemical compound N#CC1=CC(F)=CC(C2=CC(C3(CC3)C(N3)=NC(CCCN(C4)C([C@@H](C5=CC(C(F)(F)F)=CC=C5)O)=O)=C4C3=O)=CC=C2)=C1 NYFXQIUHGAINAB-MUUNZHRXSA-N 0.000 claims description 4
- XOBQQJXCTUWPME-MUUNZHRXSA-N 4-[3-[(1R)-2-[2-[1-(3-chlorophenyl)cyclopropyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-6-yl]-1-hydroxy-2-oxoethyl]phenyl]benzonitrile Chemical compound N#CC(C=C1)=CC=C1C1=CC([C@H](C(N(CCC2)CC3=C2N=C(C2(CC2)C2=CC(Cl)=CC=C2)NC3=O)=O)O)=CC=C1 XOBQQJXCTUWPME-MUUNZHRXSA-N 0.000 claims description 4
- GVERXMOIKHYIFS-GDLZYMKVSA-N 4-[3-[1-[6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-2-yl]cyclopropyl]phenyl]-N,N-dimethylbenzenesulfonamide Chemical compound CN(C)S(C(C=C1)=CC=C1C1=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=CC=C1)(=O)=O GVERXMOIKHYIFS-GDLZYMKVSA-N 0.000 claims description 4
- MDXMJRMVRUHSEA-GDLZYMKVSA-N 4-[3-[1-[6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-2-yl]cyclopropyl]phenyl]benzene-1,2-dicarbonitrile Chemical compound N#CC(C=CC(C1=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=CC=C1)=C1)=C1C#N MDXMJRMVRUHSEA-GDLZYMKVSA-N 0.000 claims description 4
- LBAFTIUGQAVFNK-MUUNZHRXSA-N 4-[3-[1-[6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-2-yl]cyclopropyl]phenyl]benzonitrile Chemical compound N#CC(C=C1)=CC=C1C1=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=CC=C1 LBAFTIUGQAVFNK-MUUNZHRXSA-N 0.000 claims description 4
- WTYQRSWXWUROHG-UHFFFAOYSA-N 4-[3-[2-[2-[1-(3-chlorophenyl)cyclopropyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-6-yl]-2-oxoethyl]phenyl]benzonitrile Chemical compound N#CC(C=C1)=CC=C1C1=CC(CC(N(CCC2)CC3=C2N=C(C2(CC2)C2=CC(Cl)=CC=C2)NC3=O)=O)=CC=C1 WTYQRSWXWUROHG-UHFFFAOYSA-N 0.000 claims description 4
- FEIBAIOARSWOQV-RUZDIDTESA-N 5-[1-[6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-2-yl]cyclopropyl]-N,N-di(propan-2-yl)thiophene-3-carboxamide Chemical compound CC(C)N(C(C)C)C(C1=CSC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1)=O FEIBAIOARSWOQV-RUZDIDTESA-N 0.000 claims description 4
- HEFARLVTPPBWFE-WJOKGBTCSA-N 5-[1-[6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-2-yl]cyclopropyl]-N-methyl-N-(naphthalen-1-ylmethyl)thiophene-3-carboxamide Chemical compound CN(CC1=CC=CC2=CC=CC=C12)C(C1=CSC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1)=O HEFARLVTPPBWFE-WJOKGBTCSA-N 0.000 claims description 4
- LETZQXSGKMVVIN-WJOKGBTCSA-N 5-[1-[6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-2-yl]cyclopropyl]-N-methyl-N-(naphthalen-2-ylmethyl)thiophene-3-carboxamide Chemical compound CN(CC1=CC2=CC=CC=C2C=C1)C(C1=CSC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1)=O LETZQXSGKMVVIN-WJOKGBTCSA-N 0.000 claims description 4
- KWXXCJHIHUXIAX-MGBGTMOVSA-N 5-[1-[6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-2-yl]cyclopropyl]-N-methyl-N-[(4-phenoxyphenyl)methyl]thiophene-3-carboxamide Chemical compound CN(CC(C=C1)=CC=C1OC1=CC=CC=C1)C(C1=CSC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1)=O KWXXCJHIHUXIAX-MGBGTMOVSA-N 0.000 claims description 4
- YCGBDMHHFKDOJO-GDLZYMKVSA-N 5-[3-[1-[6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-2-yl]cyclopropyl]phenyl]benzene-1,3-dicarbonitrile Chemical compound N#CC1=CC(C2=CC(C3(CC3)C(N3)=NC(CCCN(C4)C([C@@H](C5=CC(C(F)(F)F)=CC=C5)O)=O)=C4C3=O)=CC=C2)=CC(C#N)=C1 YCGBDMHHFKDOJO-GDLZYMKVSA-N 0.000 claims description 4
- ZMQFFDXEBMWKNN-HHHXNRCGSA-N 5-[3-[1-[6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-2-yl]cyclopropyl]phenyl]pyridine-2-carbonitrile Chemical compound N#CC(C=C1)=NC=C1C1=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=CC=C1 ZMQFFDXEBMWKNN-HHHXNRCGSA-N 0.000 claims description 4
- QBQOSDHCOLDKBS-HHHXNRCGSA-N 5-[3-[1-[6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-4-oxo-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-2-yl]cyclopropyl]phenyl]pyridine-3-carbonitrile Chemical compound N#CC1=CN=CC(C2=CC(C3(CC3)C(N3)=NC(CCCN(C4)C([C@@H](C5=CC(C(F)(F)F)=CC=C5)O)=O)=C4C3=O)=CC=C2)=C1 QBQOSDHCOLDKBS-HHHXNRCGSA-N 0.000 claims description 4
- JOXOFLXMIGJCGK-HXUWFJFHSA-N 6-[(2R)-2-(3-bromophenyl)-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC(Br)=CC=C1 JOXOFLXMIGJCGK-HXUWFJFHSA-N 0.000 claims description 4
- BVZWONRIASSZHX-OAQYLSRUSA-N 6-[(2R)-2-(3-bromophenyl)-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC(Br)=CC=C1 BVZWONRIASSZHX-OAQYLSRUSA-N 0.000 claims description 4
- NUHQGDHCOZJHJF-AREMUKBSSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-(3-cyclohexylphenyl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CC=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 NUHQGDHCOZJHJF-AREMUKBSSA-N 0.000 claims description 4
- ZMDRYEUESWXGPI-HHHXNRCGSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-(3-cyclohexylphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CC=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 ZMDRYEUESWXGPI-HHHXNRCGSA-N 0.000 claims description 4
- LFFFFMSIGDHGHR-RUZDIDTESA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-(3-cyclopentylphenyl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCC3)=CC=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 LFFFFMSIGDHGHR-RUZDIDTESA-N 0.000 claims description 4
- JIDAIYHUVFRBCU-AREMUKBSSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-(3-cyclopentylphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCC3)=CC=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 JIDAIYHUVFRBCU-AREMUKBSSA-N 0.000 claims description 4
- LETVWVFBFLKYNM-AREMUKBSSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-(3-phenoxyphenyl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(OC3=CC=CC=C3)=CC=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 LETVWVFBFLKYNM-AREMUKBSSA-N 0.000 claims description 4
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- GJAYSZZKQAWHFS-MUUNZHRXSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-(3-phenylmethoxyphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(OCC3=CC=CC=C3)=CC=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 GJAYSZZKQAWHFS-MUUNZHRXSA-N 0.000 claims description 4
- CNNCPWFIQCXGDQ-AREMUKBSSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-(3-phenylphenyl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C3=CC=CC=C3)=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 CNNCPWFIQCXGDQ-AREMUKBSSA-N 0.000 claims description 4
- HIECSPUBGRKZJX-HHHXNRCGSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-(3-phenylphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C3=CC=CC=C3)=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 HIECSPUBGRKZJX-HHHXNRCGSA-N 0.000 claims description 4
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- OETVMGJOGQCXRE-HSZRJFAPSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-(3-propan-2-ylphenyl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound CC(C)C1=CC=CC(C2(CC2)C(N2)=NC(CCN(C3)C([C@@H](C4=CC(Cl)=CC=C4)O)=O)=C3C2=O)=C1 OETVMGJOGQCXRE-HSZRJFAPSA-N 0.000 claims description 4
- ZXXVJNWZGJGJGT-XMMPIXPASA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-(3-propan-2-ylphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(Cl)=CC=C4)O)=O)=C3C2=O)=C1 ZXXVJNWZGJGJGT-XMMPIXPASA-N 0.000 claims description 4
- XCXPJCICTHQSHZ-AREMUKBSSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-(3-pyridin-3-ylphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=CN=C3)=CC=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 XCXPJCICTHQSHZ-AREMUKBSSA-N 0.000 claims description 4
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- DDQBGRMTWLITQX-RUZDIDTESA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-(4-cyclohexylthiophen-2-yl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CS1)NC2=O)=O)C1=CC(Cl)=CC=C1 DDQBGRMTWLITQX-RUZDIDTESA-N 0.000 claims description 4
- FWKMCINFUVGYDN-HSZRJFAPSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-(4-cyclopentylthiophen-2-yl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCC3)=CS1)NC2=O)=O)C1=CC(Cl)=CC=C1 FWKMCINFUVGYDN-HSZRJFAPSA-N 0.000 claims description 4
- YTCSQRKDUBKSAV-XMMPIXPASA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-(4-cyclopentylthiophen-2-yl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCC3)=CS1)NC2=O)=O)C1=CC(Cl)=CC=C1 YTCSQRKDUBKSAV-XMMPIXPASA-N 0.000 claims description 4
- SKLSVCVKSQQLTG-RUZDIDTESA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-(4-phenylthiophen-2-yl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=CC=C3)=CS1)NC2=O)=O)C1=CC(Cl)=CC=C1 SKLSVCVKSQQLTG-RUZDIDTESA-N 0.000 claims description 4
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- LTEWNOPUYSHHIK-JOCHJYFZSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-(4-propan-2-ylthiophen-2-yl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)C1=CSC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(Cl)=CC=C4)O)=O)=C3C2=O)=C1 LTEWNOPUYSHHIK-JOCHJYFZSA-N 0.000 claims description 4
- ODTWNBMNKZYNBK-RUZDIDTESA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-(5-cyclohexylpyridin-3-yl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CN=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 ODTWNBMNKZYNBK-RUZDIDTESA-N 0.000 claims description 4
- UILCMAPLJUTZNX-XMMPIXPASA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-(5-cyclopentylpyridin-3-yl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCC3)=CN=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 UILCMAPLJUTZNX-XMMPIXPASA-N 0.000 claims description 4
- NBSSMOKKPRUQJA-RUZDIDTESA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-(5-phenylpyridin-3-yl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=CC=C3)=CN=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 NBSSMOKKPRUQJA-RUZDIDTESA-N 0.000 claims description 4
- XKPQPIADCPCWAS-JOCHJYFZSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-(5-propan-2-ylpyridin-3-yl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound CC(C)C1=CN=CC(C2(CC2)C(N2)=NC(CCN(C3)C([C@@H](C4=CC(Cl)=CC=C4)O)=O)=C3C2=O)=C1 XKPQPIADCPCWAS-JOCHJYFZSA-N 0.000 claims description 4
- GFFDYFVNLDUBCH-HSZRJFAPSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-[3-(1,2-thiazol-4-yl)phenyl]cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CSN=C3)=CC=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 GFFDYFVNLDUBCH-HSZRJFAPSA-N 0.000 claims description 4
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- AMHQOKCRWKTXPU-HHHXNRCGSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-[3-(1-cyclopropylpyrazol-4-yl)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CN(C4CC4)N=C3)=CC=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 AMHQOKCRWKTXPU-HHHXNRCGSA-N 0.000 claims description 4
- WGDAFRWEKYDGMN-GDLZYMKVSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-[3-(1-methylindazol-4-yl)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CN(C1=CC=C2)N=CC1=C2C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(Cl)=CC=C4)O)=O)=C3C2=O)=C1 WGDAFRWEKYDGMN-GDLZYMKVSA-N 0.000 claims description 4
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- OCHMBONSCOFSJF-HHHXNRCGSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-[3-(3-chlorophenyl)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C3=CC(Cl)=CC=C3)=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 OCHMBONSCOFSJF-HHHXNRCGSA-N 0.000 claims description 4
- JMKJNXFWCAYDJZ-AREMUKBSSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-[3-(4,4-difluorocyclohexyl)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C(CC3)CCC3(F)F)=CC=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 JMKJNXFWCAYDJZ-AREMUKBSSA-N 0.000 claims description 4
- NZDXEEKZZAXVJH-HHHXNRCGSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-[3-(4-chlorophenyl)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C(C=C3)=CC=C3Cl)=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 NZDXEEKZZAXVJH-HHHXNRCGSA-N 0.000 claims description 4
- TYMDUGUMWAOCJO-HHHXNRCGSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-[3-(4-fluorophenyl)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C(C=C3)=CC=C3F)=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 TYMDUGUMWAOCJO-HHHXNRCGSA-N 0.000 claims description 4
- JMLUUSVVUHQQSZ-HHHXNRCGSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-[3-(cyclohexen-1-yl)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C3=CCCCC3)=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 JMLUUSVVUHQQSZ-HHHXNRCGSA-N 0.000 claims description 4
- YEIFRPZNGJQDIB-SSEXGKCCSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-[3-[3-(2-methoxyethoxy)phenyl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound COCCOC1=CC=CC(C2=CC(C3(CC3)C(N3)=NC(CCCN(C4)C([C@@H](C5=CC(Cl)=CC=C5)O)=O)=C4C3=O)=CC=C2)=C1 YEIFRPZNGJQDIB-SSEXGKCCSA-N 0.000 claims description 4
- RLKPEOLRARCPGY-HHHXNRCGSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-[3-[4-(trifluoromethyl)phenyl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C3=CC=C(C(F)(F)F)C=C3)=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 RLKPEOLRARCPGY-HHHXNRCGSA-N 0.000 claims description 4
- DBZBHJYJBSVXAN-JOCHJYFZSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-[4-(1,2-thiazol-4-yl)thiophen-2-yl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CSN=C3)=CS1)NC2=O)=O)C1=CC(Cl)=CC=C1 DBZBHJYJBSVXAN-JOCHJYFZSA-N 0.000 claims description 4
- HVBZLAJDMMOPRB-HSZRJFAPSA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-[4-(4,4-difluorocyclohexyl)thiophen-2-yl]cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C(CC3)CCC3(F)F)=CS1)NC2=O)=O)C1=CC(Cl)=CC=C1 HVBZLAJDMMOPRB-HSZRJFAPSA-N 0.000 claims description 4
- AKSYIBRLACZZKX-XMMPIXPASA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-[4-(oxan-4-yl)thiophen-2-yl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCOCC3)=CS1)NC2=O)=O)C1=CC(Cl)=CC=C1 AKSYIBRLACZZKX-XMMPIXPASA-N 0.000 claims description 4
- ZMWSDZOMWBHRMW-XMMPIXPASA-N 6-[(2R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-[1-[5-(4,4-difluorocyclohexyl)pyridin-3-yl]cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C(CC3)CCC3(F)F)=CN=C1)NC2=O)=O)C1=CC(Cl)=CC=C1 ZMWSDZOMWBHRMW-XMMPIXPASA-N 0.000 claims description 4
- STMKJKYCEZWKKI-MUUNZHRXSA-N 6-[(2R)-2-[3-(1-benzofuran-2-yl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC(C2=CC(C=CC=C3)=C3O2)=CC=C1 STMKJKYCEZWKKI-MUUNZHRXSA-N 0.000 claims description 4
- HJOFAWLMCOBZFZ-GDLZYMKVSA-N 6-[(2R)-2-[3-(1-benzofuran-2-yl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC(C2=CC(C=CC=C3)=C3O2)=CC=C1 HJOFAWLMCOBZFZ-GDLZYMKVSA-N 0.000 claims description 4
- UGAUFSIYUUDYDK-MUUNZHRXSA-N 6-[(2R)-2-[3-(1-benzofuran-3-yl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC(C2=COC3=C2C=CC=C3)=CC=C1 UGAUFSIYUUDYDK-MUUNZHRXSA-N 0.000 claims description 4
- HCRSMKISZMNXHK-GDLZYMKVSA-N 6-[(2R)-2-[3-(1-benzofuran-3-yl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC(C2=COC3=C2C=CC=C3)=CC=C1 HCRSMKISZMNXHK-GDLZYMKVSA-N 0.000 claims description 4
- LRRIUSOAFQWAGM-GDLZYMKVSA-N 6-[(2R)-2-[3-(1-benzofuran-3-yl)phenyl]-2-hydroxyacetyl]-2-[1-(3-chlorophenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC(C2=COC3=C2C=CC=C3)=CC=C1 LRRIUSOAFQWAGM-GDLZYMKVSA-N 0.000 claims description 4
- BVFFDLZFQAERPE-PGUFJCEWSA-N 6-[(2R)-2-[3-(1-benzofuran-3-yl)phenyl]-2-hydroxyacetyl]-2-[1-(3-cyclohexylphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CC=C1)NC2=O)=O)C1=CC(C2=COC3=C2C=CC=C3)=CC=C1 BVFFDLZFQAERPE-PGUFJCEWSA-N 0.000 claims description 4
- VAWWYWWRBYSFBG-MUUNZHRXSA-N 6-[(2R)-2-[3-(1-benzothiophen-2-yl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC(C2=CC(C=CC=C3)=C3S2)=CC=C1 VAWWYWWRBYSFBG-MUUNZHRXSA-N 0.000 claims description 4
- SGTZHUIVJHVYOJ-GDLZYMKVSA-N 6-[(2R)-2-[3-(1-benzothiophen-2-yl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC(C2=CC(C=CC=C3)=C3S2)=CC=C1 SGTZHUIVJHVYOJ-GDLZYMKVSA-N 0.000 claims description 4
- RBQRDAVKGYJKAX-GDLZYMKVSA-N 6-[(2R)-2-[3-(1-benzothiophen-2-yl)phenyl]-2-hydroxyacetyl]-2-[1-(3-chlorophenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC(C2=CC(C=CC=C3)=C3S2)=CC=C1 RBQRDAVKGYJKAX-GDLZYMKVSA-N 0.000 claims description 4
- UACUPKRGYPPPGS-GDLZYMKVSA-N 6-[(2R)-2-[3-(1-benzothiophen-3-yl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC(C2=CSC3=C2C=CC=C3)=CC=C1 UACUPKRGYPPPGS-GDLZYMKVSA-N 0.000 claims description 4
- YFFFIXBABVDJBL-GDLZYMKVSA-N 6-[(2R)-2-[3-(1-benzothiophen-3-yl)phenyl]-2-hydroxyacetyl]-2-[1-(3-chlorophenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC(C2=CSC3=C2C=CC=C3)=CC=C1 YFFFIXBABVDJBL-GDLZYMKVSA-N 0.000 claims description 4
- LTZGBVUUSAGTGQ-PGUFJCEWSA-N 6-[(2R)-2-[3-(1-benzothiophen-3-yl)phenyl]-2-hydroxyacetyl]-2-[1-(3-cyclohexylphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CC=C1)NC2=O)=O)C1=CC(C2=CSC3=C2C=CC=C3)=CC=C1 LTZGBVUUSAGTGQ-PGUFJCEWSA-N 0.000 claims description 4
- HHRPLOOUAZBSBS-MGBGTMOVSA-N 6-[(2R)-2-[3-(1-benzothiophen-3-yl)phenyl]-2-hydroxyacetyl]-2-[1-(4-cyclohexylthiophen-2-yl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCCCC3)=CS1)NC2=O)=O)C1=CC(C2=CSC3=C2C=CC=C3)=CC=C1 HHRPLOOUAZBSBS-MGBGTMOVSA-N 0.000 claims description 4
- BRQBOFHOJBZMKB-AREMUKBSSA-N 6-[(2R)-2-[3-(2,2-difluoro-1,3-benzodioxol-5-yl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC(C(C=C2)=CC(O3)=C2OC3(F)F)=CC=C1 BRQBOFHOJBZMKB-AREMUKBSSA-N 0.000 claims description 4
- YEHMREBAEMJPJE-HHHXNRCGSA-N 6-[(2R)-2-[3-(2,2-difluoro-1,3-benzodioxol-5-yl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC(C(C=C2)=CC(O3)=C2OC3(F)F)=CC=C1 YEHMREBAEMJPJE-HHHXNRCGSA-N 0.000 claims description 4
- YSVJOKSULVFVDE-HHHXNRCGSA-N 6-[(2R)-2-[3-(2,3-dichlorophenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C(C=CC=C2Cl)=C2Cl)=C1 YSVJOKSULVFVDE-HHHXNRCGSA-N 0.000 claims description 4
- XYLUNYCARJOFNX-AREMUKBSSA-N 6-[(2R)-2-[3-(2,5-dichlorophenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C(C=C(C=C2)Cl)=C2Cl)=C1 XYLUNYCARJOFNX-AREMUKBSSA-N 0.000 claims description 4
- RJMHPNKVBIYGLM-HHHXNRCGSA-N 6-[(2R)-2-[3-(2,5-dichlorophenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C(C=C(C=C2)Cl)=C2Cl)=C1 RJMHPNKVBIYGLM-HHHXNRCGSA-N 0.000 claims description 4
- BXULJFINLOZARH-AREMUKBSSA-N 6-[(2R)-2-[3-(3,4-dichlorophenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C(C=C2)=CC(Cl)=C2Cl)=C1 BXULJFINLOZARH-AREMUKBSSA-N 0.000 claims description 4
- AKCHNLIMRGKITO-HHHXNRCGSA-N 6-[(2R)-2-[3-(3,4-dichlorophenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C(C=C2)=CC(Cl)=C2Cl)=C1 AKCHNLIMRGKITO-HHHXNRCGSA-N 0.000 claims description 4
- QUCPYUHPKHKTHK-GDLZYMKVSA-N 6-[(2R)-2-[3-(3,4-dimethylphenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C=C1)=C(C)C=C1C1=CC([C@H](C(N(CCC2)CC3=C2N=C(C2(CC2)C2=CC=CC=C2)NC3=O)=O)O)=CC=C1 QUCPYUHPKHKTHK-GDLZYMKVSA-N 0.000 claims description 4
- QZYPOJPAZNXZEN-AREMUKBSSA-N 6-[(2R)-2-[3-(3,5-dichlorophenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(Cl)=CC(Cl)=C2)=C1 QZYPOJPAZNXZEN-AREMUKBSSA-N 0.000 claims description 4
- NUNKUGMYRKJUFH-HHHXNRCGSA-N 6-[(2R)-2-[3-(3,5-dichlorophenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(Cl)=CC(Cl)=C2)=C1 NUNKUGMYRKJUFH-HHHXNRCGSA-N 0.000 claims description 4
- KNQSINCIUKBQNX-GDLZYMKVSA-N 6-[(2R)-2-[3-(3,5-dimethylphenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC1=CC(C2=CC([C@H](C(N(CCC3)CC4=C3N=C(C3(CC3)C3=CC=CC=C3)NC4=O)=O)O)=CC=C2)=CC(C)=C1 KNQSINCIUKBQNX-GDLZYMKVSA-N 0.000 claims description 4
- LVGHPLVEPVWSPU-JGCGQSQUSA-N 6-[(2R)-2-[3-(3,5-ditert-butylphenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound CC(C)(C)C1=CC(C2=CC([C@H](C(N(CC3)CC4=C3N=C(C3(CC3)C3=CC=CC=C3)NC4=O)=O)O)=CC=C2)=CC(C(C)(C)C)=C1 LVGHPLVEPVWSPU-JGCGQSQUSA-N 0.000 claims description 4
- DYDRIGXLFCCXEQ-AREMUKBSSA-N 6-[(2R)-2-[3-(3-chloro-4-fluorophenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C(C=C2)=CC(Cl)=C2F)=C1 DYDRIGXLFCCXEQ-AREMUKBSSA-N 0.000 claims description 4
- FEMXIVYSIGGMIQ-HHHXNRCGSA-N 6-[(2R)-2-[3-(3-chloro-4-fluorophenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C(C=C2)=CC(Cl)=C2F)=C1 FEMXIVYSIGGMIQ-HHHXNRCGSA-N 0.000 claims description 4
- CXOHEBYLVLMVAP-AREMUKBSSA-N 6-[(2R)-2-[3-(3-chloro-4-fluorophenyl)phenyl]-2-hydroxyacetyl]-2-[1-(3-chlorophenyl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C(C=C2)=CC(Cl)=C2F)=C1 CXOHEBYLVLMVAP-AREMUKBSSA-N 0.000 claims description 4
- RNURULLBARJKHL-HHHXNRCGSA-N 6-[(2R)-2-[3-(3-chloro-4-fluorophenyl)phenyl]-2-hydroxyacetyl]-2-[1-(3-chlorophenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C(C=C2)=CC(Cl)=C2F)=C1 RNURULLBARJKHL-HHHXNRCGSA-N 0.000 claims description 4
- DANMNUBWJJOWSJ-HHHXNRCGSA-N 6-[(2R)-2-[3-(3-chloro-4-methylphenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound CC(C=CC(C1=CC([C@H](C(N(CC2)CC3=C2N=C(C2(CC2)C2=CC=CC=C2)NC3=O)=O)O)=CC=C1)=C1)=C1Cl DANMNUBWJJOWSJ-HHHXNRCGSA-N 0.000 claims description 4
- PTIQAYZTGUHIMQ-MUUNZHRXSA-N 6-[(2R)-2-[3-(3-chloro-4-methylphenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C=CC(C1=CC([C@H](C(N(CCC2)CC3=C2N=C(C2(CC2)C2=CC=CC=C2)NC3=O)=O)O)=CC=C1)=C1)=C1Cl PTIQAYZTGUHIMQ-MUUNZHRXSA-N 0.000 claims description 4
- YWGNSYXCGDKURI-AREMUKBSSA-N 6-[(2R)-2-[3-(3-chloro-5-fluorophenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(Cl)=CC(F)=C2)=C1 YWGNSYXCGDKURI-AREMUKBSSA-N 0.000 claims description 4
- QRWGJCRXGMWPDD-HHHXNRCGSA-N 6-[(2R)-2-[3-(3-chloro-5-fluorophenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(Cl)=CC(F)=C2)=C1 QRWGJCRXGMWPDD-HHHXNRCGSA-N 0.000 claims description 4
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- GZIVZHYAFDMXLQ-HHHXNRCGSA-N 6-[(2R)-2-[3-(3-chloro-5-fluorophenyl)phenyl]-2-hydroxyacetyl]-2-[1-(3-chlorophenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(Cl)=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(Cl)=CC(F)=C2)=C1 GZIVZHYAFDMXLQ-HHHXNRCGSA-N 0.000 claims description 4
- MZBQXRQTQPPWSV-HHHXNRCGSA-N 6-[(2R)-2-[3-(3-chloro-5-methylphenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound CC1=CC(C2=CC([C@H](C(N(CC3)CC4=C3N=C(C3(CC3)C3=CC=CC=C3)NC4=O)=O)O)=CC=C2)=CC(Cl)=C1 MZBQXRQTQPPWSV-HHHXNRCGSA-N 0.000 claims description 4
- DOTAXXPQMNDGGR-MUUNZHRXSA-N 6-[(2R)-2-[3-(3-chloro-5-methylphenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC1=CC(C2=CC([C@H](C(N(CCC3)CC4=C3N=C(C3(CC3)C3=CC=CC=C3)NC4=O)=O)O)=CC=C2)=CC(Cl)=C1 DOTAXXPQMNDGGR-MUUNZHRXSA-N 0.000 claims description 4
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- QXYBBJAZQFXPFY-HHHXNRCGSA-N 6-[(2R)-2-[3-(4-chlorophenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C(C=C2)=CC=C2Cl)=C1 QXYBBJAZQFXPFY-HHHXNRCGSA-N 0.000 claims description 4
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- XMSXAXAILLXHEG-MUUNZHRXSA-N 6-[(2R)-2-[3-(4-fluorophenyl)phenyl]-2-hydroxyacetyl]-2-[1-(5-propan-2-ylpyridin-3-yl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound CC(C)C1=CN=CC(C2(CC2)C(N2)=NC(CCN(C3)C([C@@H](C4=CC=CC(C(C=C5)=CC=C5F)=C4)O)=O)=C3C2=O)=C1 XMSXAXAILLXHEG-MUUNZHRXSA-N 0.000 claims description 4
- CAZFZOWBJGEVIN-SSEXGKCCSA-N 6-[(2R)-2-[3-(4-tert-butylphenyl)phenyl]-2-hydroxyacetyl]-2-[1-(3-chlorophenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)(C)C(C=C1)=CC=C1C1=CC([C@H](C(N(CCC2)CC3=C2N=C(C2(CC2)C2=CC(Cl)=CC=C2)NC3=O)=O)O)=CC=C1 CAZFZOWBJGEVIN-SSEXGKCCSA-N 0.000 claims description 4
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- XZMRTEOBOOBJGH-HHHXNRCGSA-N 6-[(2R)-2-[3-[3,5-bis(trifluoromethyl)phenyl]phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=C1 XZMRTEOBOOBJGH-HHHXNRCGSA-N 0.000 claims description 4
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- YSBGHCDQUMJCEM-HHHXNRCGSA-N 6-[(2R)-2-[3-[3-chloro-5-(trifluoromethoxy)phenyl]phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(Cl)=CC(OC(F)(F)F)=C2)=C1 YSBGHCDQUMJCEM-HHHXNRCGSA-N 0.000 claims description 4
- ZTJZIYPZJXNOAF-AREMUKBSSA-N 6-[(2R)-2-[3-[3-chloro-5-(trifluoromethyl)phenyl]phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(Cl)=CC(C(F)(F)F)=C2)=C1 ZTJZIYPZJXNOAF-AREMUKBSSA-N 0.000 claims description 4
- NGKMWMJKAPVODI-HHHXNRCGSA-N 6-[(2R)-2-[3-[3-chloro-5-(trifluoromethyl)phenyl]phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(Cl)=CC(C(F)(F)F)=C2)=C1 NGKMWMJKAPVODI-HHHXNRCGSA-N 0.000 claims description 4
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- VDOPRLPFKXYXTJ-HHHXNRCGSA-N 6-[(2R)-2-[3-[4-chloro-3-(trifluoromethoxy)phenyl]phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C(C=C2)=CC(OC(F)(F)F)=C2Cl)=C1 VDOPRLPFKXYXTJ-HHHXNRCGSA-N 0.000 claims description 4
- OQOAKLGMWCMNOH-AREMUKBSSA-N 6-[(2R)-2-[3-[4-chloro-3-(trifluoromethyl)phenyl]phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C(C=C2)=CC(C(F)(F)F)=C2Cl)=C1 OQOAKLGMWCMNOH-AREMUKBSSA-N 0.000 claims description 4
- UGHFRGGCEMNBAS-HHHXNRCGSA-N 6-[(2R)-2-[3-[4-chloro-3-(trifluoromethyl)phenyl]phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C(C=C2)=CC(C(F)(F)F)=C2Cl)=C1 UGHFRGGCEMNBAS-HHHXNRCGSA-N 0.000 claims description 4
- CZHMNOORLQRJTL-GDLZYMKVSA-N 6-[(2R)-2-hydroxy-2-(3-quinolin-3-ylphenyl)acetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC(C2=CC3=CC=CC=C3N=C2)=CC=C1 CZHMNOORLQRJTL-GDLZYMKVSA-N 0.000 claims description 4
- GAUSAZSQFMNWNU-MGBGTMOVSA-N 6-[(2R)-2-hydroxy-2-[3-(3-phenylmethoxyphenyl)phenyl]acetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(OCC3=CC=CC=C3)=CC=C2)=C1 GAUSAZSQFMNWNU-MGBGTMOVSA-N 0.000 claims description 4
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- UBCFEALEWPBLHV-MGBGTMOVSA-N 6-[(2R)-2-hydroxy-2-[3-(4-phenylmethoxyphenyl)phenyl]acetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C(C=C2)=CC=C2OCC2=CC=CC=C2)=C1 UBCFEALEWPBLHV-MGBGTMOVSA-N 0.000 claims description 4
- DTZGEXLPIDCVKV-JGCGQSQUSA-N 6-[(2R)-2-hydroxy-2-[3-(6-phenylmethoxypyridin-3-yl)phenyl]acetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC(C(C=N2)=CC=C2OCC2=CC=CC=C2)=CC=C1 DTZGEXLPIDCVKV-JGCGQSQUSA-N 0.000 claims description 4
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- OSHXUMBPEUTGPB-HSZRJFAPSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(2-propan-2-ylpyridin-4-yl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)C1=NC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 OSHXUMBPEUTGPB-HSZRJFAPSA-N 0.000 claims description 4
- BCTHLZUANOSUJE-WJOKGBTCSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(3-naphthalen-1-ylphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=CC4=CC=CC=C34)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 BCTHLZUANOSUJE-WJOKGBTCSA-N 0.000 claims description 4
- IBEFVNWGQATJHK-WJOKGBTCSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(3-naphthalen-2-ylphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC4=CC=CC=C4C=C3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 IBEFVNWGQATJHK-WJOKGBTCSA-N 0.000 claims description 4
- VAYDEQLAARYPRV-AREMUKBSSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(3-phenoxyphenyl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(OC3=CC=CC=C3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 VAYDEQLAARYPRV-AREMUKBSSA-N 0.000 claims description 4
- AXJWOPQXOOMQQQ-HHHXNRCGSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(3-phenoxyphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(OC3=CC=CC=C3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 AXJWOPQXOOMQQQ-HHHXNRCGSA-N 0.000 claims description 4
- KBHPEYUQQAKBKA-MUUNZHRXSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(3-phenylmethoxyphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(OCC3=CC=CC=C3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 KBHPEYUQQAKBKA-MUUNZHRXSA-N 0.000 claims description 4
- SQDAYKCPYNCAFN-AREMUKBSSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(3-phenylphenyl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C3=CC=CC=C3)=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 SQDAYKCPYNCAFN-AREMUKBSSA-N 0.000 claims description 4
- BVLVWZUDSNYCAU-HHHXNRCGSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(3-phenylphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C3=CC=CC=C3)=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 BVLVWZUDSNYCAU-HHHXNRCGSA-N 0.000 claims description 4
- LZDGMEKXTHPYHB-XMMPIXPASA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(3-prop-1-en-2-ylphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1)=C LZDGMEKXTHPYHB-XMMPIXPASA-N 0.000 claims description 4
- YKNIEGNDGJSOJN-HSZRJFAPSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(3-propan-2-ylphenyl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound CC(C)C1=CC=CC(C2(CC2)C(N2)=NC(CCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 YKNIEGNDGJSOJN-HSZRJFAPSA-N 0.000 claims description 4
- CTTAVDITUXVCMM-XMMPIXPASA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(3-propan-2-ylphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 CTTAVDITUXVCMM-XMMPIXPASA-N 0.000 claims description 4
- OCELAPCIMJZEGE-RUZDIDTESA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(3-pyridin-3-ylphenyl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=CN=C3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 OCELAPCIMJZEGE-RUZDIDTESA-N 0.000 claims description 4
- VYXTWOQDHSNHRB-AREMUKBSSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(3-pyridin-3-ylphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=CN=C3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 VYXTWOQDHSNHRB-AREMUKBSSA-N 0.000 claims description 4
- YSAGNQZIVLRLGR-AREMUKBSSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(3-pyridin-4-ylphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=NC=C3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 YSAGNQZIVLRLGR-AREMUKBSSA-N 0.000 claims description 4
- JUHPFDRPSGKSEP-RUZDIDTESA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(3-pyrimidin-5-ylphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CN=CN=C3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 JUHPFDRPSGKSEP-RUZDIDTESA-N 0.000 claims description 4
- AGGGKFBOXBKHPY-XMMPIXPASA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(4-phenylthiophen-2-yl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=CC=C3)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 AGGGKFBOXBKHPY-XMMPIXPASA-N 0.000 claims description 4
- JGFLRBMHSDPKPM-RUZDIDTESA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(4-phenylthiophen-2-yl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=CC=C3)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 JGFLRBMHSDPKPM-RUZDIDTESA-N 0.000 claims description 4
- NQCQLXARDFPQDK-OAQYLSRUSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(4-propan-2-ylthiophen-2-yl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound CC(C)C1=CSC(C2(CC2)C(N2)=NC(CCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 NQCQLXARDFPQDK-OAQYLSRUSA-N 0.000 claims description 4
- VUFYQLRJKQCYTN-JOCHJYFZSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(4-propan-2-ylthiophen-2-yl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)C1=CSC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 VUFYQLRJKQCYTN-JOCHJYFZSA-N 0.000 claims description 4
- VYCMQKLUSYVDRB-RUZDIDTESA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(5-phenylpyridin-3-yl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=CC=C3)=CN=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 VYCMQKLUSYVDRB-RUZDIDTESA-N 0.000 claims description 4
- ADZAIQHBWAWNLQ-AREMUKBSSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(5-phenylpyridin-3-yl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=CC=C3)=CN=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 ADZAIQHBWAWNLQ-AREMUKBSSA-N 0.000 claims description 4
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- AZMGRVFNRWVWAO-IJBYHRAESA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-(1,1,1-trifluoropropan-2-yl)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C(F)(F)F)C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 AZMGRVFNRWVWAO-IJBYHRAESA-N 0.000 claims description 4
- WDXSYFRYIGMGBU-HSZRJFAPSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-(1,2-thiazol-4-yl)phenyl]cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CSN=C3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 WDXSYFRYIGMGBU-HSZRJFAPSA-N 0.000 claims description 4
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- VWRPJRKYDAAGNL-XMMPIXPASA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-(1,3-oxazol-5-yl)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CN=CO3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 VWRPJRKYDAAGNL-XMMPIXPASA-N 0.000 claims description 4
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- BWQGWKKSPALHAH-GDLZYMKVSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-(1-methylindazol-4-yl)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CN(C1=CC=C2)N=CC1=C2C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 BWQGWKKSPALHAH-GDLZYMKVSA-N 0.000 claims description 4
- IUBULSZYHYGWHS-GDLZYMKVSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-(1-methylindazol-5-yl)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CN1N=CC2=CC(C3=CC=CC(C4(CC4)C(N4)=NC(CCCN(C5)C([C@@H](C6=CC(C(F)(F)F)=CC=C6)O)=O)=C5C4=O)=C3)=CC=C12 IUBULSZYHYGWHS-GDLZYMKVSA-N 0.000 claims description 4
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- QDWDNNUQJQZATC-MUUNZHRXSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-(2-methylphenyl)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C=CC=C1)=C1C1=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=CC=C1 QDWDNNUQJQZATC-MUUNZHRXSA-N 0.000 claims description 4
- PBDJJCDMXDRMNC-RUZDIDTESA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-(2-methylpropyl)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)CC1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 PBDJJCDMXDRMNC-RUZDIDTESA-N 0.000 claims description 4
- XROPTIDHNBFJEK-RUZDIDTESA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-(2-methylpyrazol-3-yl)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CN1N=CC=C1C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 XROPTIDHNBFJEK-RUZDIDTESA-N 0.000 claims description 4
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- JEMTZXCASIWEME-HHHXNRCGSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-(6-methoxypyridin-3-yl)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound COC(N=C1)=CC=C1C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 JEMTZXCASIWEME-HHHXNRCGSA-N 0.000 claims description 4
- MKNLDKHSYSNTNJ-SSEXGKCCSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-(6-pyrrolidin-1-ylpyridin-3-yl)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=C(N4CCCC4)N=C3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 MKNLDKHSYSNTNJ-SSEXGKCCSA-N 0.000 claims description 4
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- BBFOWFGKXLATML-AREMUKBSSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-(oxan-4-yl)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCOCC3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 BBFOWFGKXLATML-AREMUKBSSA-N 0.000 claims description 4
- UOOMHAIBYANINS-OAQYLSRUSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-(trifluoromethoxy)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(OC(F)(F)F)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 UOOMHAIBYANINS-OAQYLSRUSA-N 0.000 claims description 4
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- KNJZAPUUPLATEP-HHHXNRCGSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[1-(2-methoxyethyl)pyrazol-4-yl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound COCCN1N=CC(C2=CC=CC(C3(CC3)C(N3)=NC(CCCN(C4)C([C@@H](C5=CC(C(F)(F)F)=CC=C5)O)=O)=C4C3=O)=C2)=C1 KNJZAPUUPLATEP-HHHXNRCGSA-N 0.000 claims description 4
- HYPRNIPHLPDQJL-UUWRZZSWSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[1-(2-phenylacetyl)piperidin-4-yl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C(CC3)CCN3C(CC3=CC=CC=C3)=O)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 HYPRNIPHLPDQJL-UUWRZZSWSA-N 0.000 claims description 4
- GAMPYOVVGIPQMP-PGUFJCEWSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[1-(3-phenylpropanoyl)piperidin-4-yl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C(CC3)CCN3C(CCC3=CC=CC=C3)=O)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 GAMPYOVVGIPQMP-PGUFJCEWSA-N 0.000 claims description 4
- GJRTZUWOQUHUCW-WJOKGBTCSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[1-(piperidine-1-carbonyl)-3,6-dihydro-2H-pyridin-4-yl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C(CC3)=CCN3C(N3CCCCC3)=O)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 GJRTZUWOQUHUCW-WJOKGBTCSA-N 0.000 claims description 4
- OQTAEWZPTNIEJX-HHHXNRCGSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[2-(methylamino)pyridin-4-yl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CNC1=NC=CC(C2=CC=CC(C3(CC3)C(N3)=NC(CCCN(C4)C([C@@H](C5=CC(C(F)(F)F)=CC=C5)O)=O)=C4C3=O)=C2)=C1 OQTAEWZPTNIEJX-HHHXNRCGSA-N 0.000 claims description 4
- CENSNKYUYVDXLH-AREMUKBSSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[2-(trifluoromethyl)pyridin-4-yl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC(C(F)(F)F)=NC=C3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 CENSNKYUYVDXLH-AREMUKBSSA-N 0.000 claims description 4
- ADEKUWOVWSGCEW-SSEXGKCCSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[3-(2-methoxyethoxy)phenyl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound COCCOC1=CC=CC(C2=CC(C3(CC3)C(N3)=NC(CCCN(C4)C([C@@H](C5=CC(C(F)(F)F)=CC=C5)O)=O)=C4C3=O)=CC=C2)=C1 ADEKUWOVWSGCEW-SSEXGKCCSA-N 0.000 claims description 4
- NXOVLFOKHJVWMR-JGCGQSQUSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[3-(piperidine-1-carbonyl)phenyl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C3=CC(C(N4CCCCC4)=O)=CC=C3)=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 NXOVLFOKHJVWMR-JGCGQSQUSA-N 0.000 claims description 4
- NNULVRPXGIGCNN-MGBGTMOVSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[4-(pyridin-2-ylmethoxy)phenyl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C(C=C3)=CC=C3OCC3=NC=CC=C3)=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 NNULVRPXGIGCNN-MGBGTMOVSA-N 0.000 claims description 4
- KPHROUKWJSDGHB-RZIURPKCSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[4-(trifluoromethyl)cyclohexen-1-yl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C(CC3)=CCC3C(F)(F)F)=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 KPHROUKWJSDGHB-RZIURPKCSA-N 0.000 claims description 4
- TVPLKJOCOWBKPF-RRHRGVEJSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[4-[(4-phenylmethoxypiperidin-1-yl)methyl]phenyl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C3=CC=C(CN(CC4)CCC4OCC4=CC=CC=C4)C=C3)=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 TVPLKJOCOWBKPF-RRHRGVEJSA-N 0.000 claims description 4
- PDYSFJCKRMBLGB-AREMUKBSSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[5-(trifluoromethyl)pyridin-3-yl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC(C(F)(F)F)=CN=C3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 PDYSFJCKRMBLGB-AREMUKBSSA-N 0.000 claims description 4
- XSJKLGJGBAWESD-JGCGQSQUSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[6-(4-methylpiperidin-1-yl)pyridin-3-yl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(CC1)CCN1C(N=C1)=CC=C1C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 XSJKLGJGBAWESD-JGCGQSQUSA-N 0.000 claims description 4
- YFBWMBXLSPMCRM-KXQOOQHDSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[6-(4-phenylmethoxypiperidin-1-yl)pyridin-3-yl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=C(N(CC4)CCC4OCC4=CC=CC=C4)N=C3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 YFBWMBXLSPMCRM-KXQOOQHDSA-N 0.000 claims description 4
- BFUMVMYTVKMJBW-DIPNUNPCSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[6-(4-phenylpiperidin-1-yl)pyridin-3-yl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=C(N(CC4)CCC4C4=CC=CC=C4)N=C3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 BFUMVMYTVKMJBW-DIPNUNPCSA-N 0.000 claims description 4
- WNUUEHYYGQGGAB-HHHXNRCGSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[6-(methylamino)pyridin-3-yl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CNC(N=C1)=CC=C1C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 WNUUEHYYGQGGAB-HHHXNRCGSA-N 0.000 claims description 4
- KXPNJJNLJNVSIL-AREMUKBSSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[6-(trifluoromethyl)pyridin-3-yl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=C(C(F)(F)F)N=C3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 KXPNJJNLJNVSIL-AREMUKBSSA-N 0.000 claims description 4
- ZXIFOZNKMGVZDV-MGBGTMOVSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[6-[4-(2-methylpropanoyl)piperazin-1-yl]pyridin-3-yl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)C(N(CC1)CCN1C(N=C1)=CC=C1C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1)=O ZXIFOZNKMGVZDV-MGBGTMOVSA-N 0.000 claims description 4
- GLQYUKGDORLRKV-KXQOOQHDSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[6-[4-(2-phenylacetyl)piperazin-1-yl]pyridin-3-yl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=C(N(CC4)CCN4C(CC4=CC=CC=C4)=O)N=C3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 GLQYUKGDORLRKV-KXQOOQHDSA-N 0.000 claims description 4
- KKJCGQWDZDTQFH-JOCHJYFZSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[4-(1,2-thiazol-4-yl)thiophen-2-yl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CSN=C3)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 KKJCGQWDZDTQFH-JOCHJYFZSA-N 0.000 claims description 4
- YEADKVPCEALRRM-HHHXNRCGSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[4-(2-phenylethyl)thiophen-2-yl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(CCC3=CC=CC=C3)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 YEADKVPCEALRRM-HHHXNRCGSA-N 0.000 claims description 4
- AMXVUZVMDVULMN-HSZRJFAPSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[4-(3-methoxypropyl)thiophen-2-yl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound COCCCC1=CSC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 AMXVUZVMDVULMN-HSZRJFAPSA-N 0.000 claims description 4
- COPOAWWHFZZNPS-XMMPIXPASA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[4-(oxan-4-yl)thiophen-2-yl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCOCC3)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 COPOAWWHFZZNPS-XMMPIXPASA-N 0.000 claims description 4
- JOIMZLZSAHOONW-AREMUKBSSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[4-[2-(oxan-4-yl)ethyl]thiophen-2-yl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(CCC3CCOCC3)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 JOIMZLZSAHOONW-AREMUKBSSA-N 0.000 claims description 4
- QSTRGKRICJSOTR-XMMPIXPASA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[4-[2-(oxetan-3-yl)ethyl]thiophen-2-yl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(CCC3COC3)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 QSTRGKRICJSOTR-XMMPIXPASA-N 0.000 claims description 4
- FKOMJIAUIQBFKK-HXUWFJFHSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[5-(trifluoromethyl)pyridin-3-yl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C(F)(F)F)=CN=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 FKOMJIAUIQBFKK-HXUWFJFHSA-N 0.000 claims description 4
- ILUVXSFVPKPVQP-RUZDIDTESA-N 6-[(2R)-2-hydroxy-2-[3-[2-(trifluoromethyl)pyridin-4-yl]phenyl]acetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC(C2=CC(C(F)(F)F)=NC=C2)=CC=C1 ILUVXSFVPKPVQP-RUZDIDTESA-N 0.000 claims description 4
- VBSRLACFWZTAJD-AREMUKBSSA-N 6-[(2R)-2-hydroxy-2-[3-[2-(trifluoromethyl)pyridin-4-yl]phenyl]acetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC(C2=CC(C(F)(F)F)=NC=C2)=CC=C1 VBSRLACFWZTAJD-AREMUKBSSA-N 0.000 claims description 4
- ZJOYQEPCEZOXDY-MUUNZHRXSA-N 6-[(2R)-2-hydroxy-2-[3-[2-(trifluoromethyl)pyridin-4-yl]phenyl]acetyl]-2-[1-(3-propan-2-ylphenyl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound CC(C)C1=CC=CC(C2(CC2)C(N2)=NC(CCN(C3)C([C@@H](C4=CC(C5=CC(C(F)(F)F)=NC=C5)=CC=C4)O)=O)=C3C2=O)=C1 ZJOYQEPCEZOXDY-MUUNZHRXSA-N 0.000 claims description 4
- RCPQEESAGHXRMK-GDLZYMKVSA-N 6-[(2R)-2-hydroxy-2-[3-[2-(trifluoromethyl)pyridin-4-yl]phenyl]acetyl]-2-[1-(3-propan-2-ylphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C5=CC(C(F)(F)F)=NC=C5)=CC=C4)O)=O)=C3C2=O)=C1 RCPQEESAGHXRMK-GDLZYMKVSA-N 0.000 claims description 4
- LCAIINGNKDQBIT-HHHXNRCGSA-N 6-[(2R)-2-hydroxy-2-[3-[2-(trifluoromethyl)pyridin-4-yl]phenyl]acetyl]-2-[1-(4-propan-2-ylthiophen-2-yl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)C1=CSC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C5=CC(C(F)(F)F)=NC=C5)=CC=C4)O)=O)=C3C2=O)=C1 LCAIINGNKDQBIT-HHHXNRCGSA-N 0.000 claims description 4
- CBXJOJWXFWROAD-MUUNZHRXSA-N 6-[(2R)-2-hydroxy-2-[3-[2-(trifluoromethyl)pyridin-4-yl]phenyl]acetyl]-2-[1-(5-propan-2-ylpyridin-3-yl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)C1=CN=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C5=CC(C(F)(F)F)=NC=C5)=CC=C4)O)=O)=C3C2=O)=C1 CBXJOJWXFWROAD-MUUNZHRXSA-N 0.000 claims description 4
- NVMQEWNHDKBLBQ-AREMUKBSSA-N 6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(OC(F)(F)F)=CC=C2)=C1 NVMQEWNHDKBLBQ-AREMUKBSSA-N 0.000 claims description 4
- UCANSNLDRLESGT-HHHXNRCGSA-N 6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(OC(F)(F)F)=CC=C2)=C1 UCANSNLDRLESGT-HHHXNRCGSA-N 0.000 claims description 4
- BWWJPUHUXAUBEF-RUZDIDTESA-N 6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-2-(1-thiophen-2-ylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CS1)NC2=O)=O)C1=CC=CC(C2=CC(OC(F)(F)F)=CC=C2)=C1 BWWJPUHUXAUBEF-RUZDIDTESA-N 0.000 claims description 4
- MDZCHWGWONFGCA-GDLZYMKVSA-N 6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-2-[1-(3-propan-2-ylphenyl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound CC(C)C1=CC=CC(C2(CC2)C(N2)=NC(CCN(C3)C([C@@H](C4=CC=CC(C5=CC(OC(F)(F)F)=CC=C5)=C4)O)=O)=C3C2=O)=C1 MDZCHWGWONFGCA-GDLZYMKVSA-N 0.000 claims description 4
- PMBFJHDMXPDWOT-SSEXGKCCSA-N 6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-2-[1-(3-propan-2-ylphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC=CC(C5=CC(OC(F)(F)F)=CC=C5)=C4)O)=O)=C3C2=O)=C1 PMBFJHDMXPDWOT-SSEXGKCCSA-N 0.000 claims description 4
- HEMVQPDTSMNUHK-WJOKGBTCSA-N 6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-2-[1-(4-phenylthiophen-2-yl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=CC=C3)=CS1)NC2=O)=O)C1=CC=CC(C2=CC(OC(F)(F)F)=CC=C2)=C1 HEMVQPDTSMNUHK-WJOKGBTCSA-N 0.000 claims description 4
- CKVXMBRBWXOPKI-MUUNZHRXSA-N 6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-2-[1-(4-propan-2-ylthiophen-2-yl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)C1=CSC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC=CC(C5=CC(OC(F)(F)F)=CC=C5)=C4)O)=O)=C3C2=O)=C1 CKVXMBRBWXOPKI-MUUNZHRXSA-N 0.000 claims description 4
- LVGGHPWEHSPCOY-JGCGQSQUSA-N 6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-2-[1-(5-phenylpyridin-3-yl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=CC=C3)=CN=C1)NC2=O)=O)C1=CC=CC(C2=CC(OC(F)(F)F)=CC=C2)=C1 LVGGHPWEHSPCOY-JGCGQSQUSA-N 0.000 claims description 4
- UJTNDKHPRLPMMD-GDLZYMKVSA-N 6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-2-[1-(5-propan-2-ylpyridin-3-yl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)C1=CN=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC=CC(C5=CC(OC(F)(F)F)=CC=C5)=C4)O)=O)=C3C2=O)=C1 UJTNDKHPRLPMMD-GDLZYMKVSA-N 0.000 claims description 4
- YEXQOPQCLRWLIV-AREMUKBSSA-N 6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(C(F)(F)F)=CC=C2)=C1 YEXQOPQCLRWLIV-AREMUKBSSA-N 0.000 claims description 4
- ICLDEHXMBIJEML-HHHXNRCGSA-N 6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(C(F)(F)F)=CC=C2)=C1 ICLDEHXMBIJEML-HHHXNRCGSA-N 0.000 claims description 4
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- RFPONOCDAFZOFJ-SSEXGKCCSA-N 6-[(2R)-2-hydroxy-2-[3-[3-(trifluoromethyl)phenyl]phenyl]acetyl]-2-[1-(3-propan-2-ylphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC=CC(C5=CC(C(F)(F)F)=CC=C5)=C4)O)=O)=C3C2=O)=C1 RFPONOCDAFZOFJ-SSEXGKCCSA-N 0.000 claims description 4
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- NCFZPIFDLRLKPM-MUUNZHRXSA-N 6-[(2R)-2-hydroxy-2-[3-[4-(trifluoromethyl)phenyl]phenyl]acetyl]-2-[1-(5-propan-2-ylpyridin-3-yl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound CC(C)C1=CN=CC(C2(CC2)C(N2)=NC(CCN(C3)C([C@@H](C4=CC=CC(C5=CC=C(C(F)(F)F)C=C5)=C4)O)=O)=C3C2=O)=C1 NCFZPIFDLRLKPM-MUUNZHRXSA-N 0.000 claims description 4
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- NEJFTLSWQFODBV-AREMUKBSSA-N 6-[(2R)-2-hydroxy-2-[3-[5-(trifluoromethyl)pyridin-3-yl]phenyl]acetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC(C2=CC(C(F)(F)F)=CN=C2)=CC=C1 NEJFTLSWQFODBV-AREMUKBSSA-N 0.000 claims description 4
- GIIMCKMWIWZEFY-RUZDIDTESA-N 6-[(2R)-2-hydroxy-2-[3-[6-(trifluoromethyl)pyridin-2-yl]phenyl]acetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC(C2=NC(C(F)(F)F)=CC=C2)=CC=C1 GIIMCKMWIWZEFY-RUZDIDTESA-N 0.000 claims description 4
- SLDGIRZIDJHKDH-AREMUKBSSA-N 6-[(2R)-2-hydroxy-2-[3-[6-(trifluoromethyl)pyridin-2-yl]phenyl]acetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC(C2=NC(C(F)(F)F)=CC=C2)=CC=C1 SLDGIRZIDJHKDH-AREMUKBSSA-N 0.000 claims description 4
- WOGUCZDGKSLCIP-HHHXNRCGSA-N 6-[(2R)-2-hydroxy-2-[3-[6-(trifluoromethyl)pyridin-3-yl]phenyl]acetyl]-2-[1-(5-propan-2-ylpyridin-3-yl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound CC(C)C1=CN=CC(C2(CC2)C(N2)=NC(CCN(C3)C([C@@H](C4=CC(C5=CC=C(C(F)(F)F)N=C5)=CC=C4)O)=O)=C3C2=O)=C1 WOGUCZDGKSLCIP-HHHXNRCGSA-N 0.000 claims description 4
- AMOUNJDDLKFWDU-UHFFFAOYSA-N 6-[2,2-difluoro-2-[3-(3-propan-2-yloxyphenyl)phenyl]acetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)OC1=CC=CC(C2=CC(C(C(N(CCC3)CC4=C3N=C(C3(CC3)C3=CC=CC=C3)NC4=O)=O)(F)F)=CC=C2)=C1 AMOUNJDDLKFWDU-UHFFFAOYSA-N 0.000 claims description 4
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- WDDWYPDZWONBAK-UHFFFAOYSA-N 6-[2,2-difluoro-2-[3-[3-(trifluoromethoxy)phenyl]phenyl]acetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O=C(C(C1=CC=CC(C2=CC(OC(F)(F)F)=CC=C2)=C1)(F)F)N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O WDDWYPDZWONBAK-UHFFFAOYSA-N 0.000 claims description 4
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- DZWQTKCWBISVFC-UHFFFAOYSA-N 6-[2-(3-bromo-2-fluorophenyl)-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound OC(C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C(C=CC=C1Br)=C1F DZWQTKCWBISVFC-UHFFFAOYSA-N 0.000 claims description 4
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- JXMBERYTTPHGJQ-HSZRJFAPSA-N 6-[(2R)-2-hydroxy-2-[3-(1,3-oxazol-5-yl)phenyl]acetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC(C2=CN=CO2)=CC=C1 JXMBERYTTPHGJQ-HSZRJFAPSA-N 0.000 claims description 2
- CVMMPLWROKBEMT-MGBGTMOVSA-N 6-[(2R)-2-hydroxy-2-[3-(2-phenylmethoxyphenyl)phenyl]acetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C(C=CC=C2)=C2OCC2=CC=CC=C2)=C1 CVMMPLWROKBEMT-MGBGTMOVSA-N 0.000 claims description 2
- ZVFDKSTYVBZBQV-HXUWFJFHSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 ZVFDKSTYVBZBQV-HXUWFJFHSA-N 0.000 claims description 2
- JRSPCQVULLGETO-GOSISDBHSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-(1-thiophen-2-ylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 JRSPCQVULLGETO-GOSISDBHSA-N 0.000 claims description 2
- KGTTUVSYSYCOEN-HSZRJFAPSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(1-methylindazol-4-yl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CN1N=CC2=C(C3(CC3)C(N3)=NC(CCCN(C4)C([C@@H](C5=CC(C(F)(F)F)=CC=C5)O)=O)=C4C3=O)C=CC=C12 KGTTUVSYSYCOEN-HSZRJFAPSA-N 0.000 claims description 2
- APUAEMWBHIZXBI-HSZRJFAPSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(2-phenyl-1,3-oxazol-5-yl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CN=C(C3=CC=CC=C3)O1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 APUAEMWBHIZXBI-HSZRJFAPSA-N 0.000 claims description 2
- GGTOQRWQRBDIHQ-JOCHJYFZSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(3-methoxyphenyl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound COC1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 GGTOQRWQRBDIHQ-JOCHJYFZSA-N 0.000 claims description 2
- NTYAKABTCMCRJZ-XMMPIXPASA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(4-piperidin-4-ylthiophen-2-yl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCNCC3)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 NTYAKABTCMCRJZ-XMMPIXPASA-N 0.000 claims description 2
- NLWFUMUCKWAZSS-HSZRJFAPSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(4-pyridin-3-ylthiophen-2-yl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=CN=C3)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 NLWFUMUCKWAZSS-HSZRJFAPSA-N 0.000 claims description 2
- JZOQFKKFIINBQH-XMMPIXPASA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(4-pyridin-3-ylthiophen-2-yl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CC=CN=C3)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 JZOQFKKFIINBQH-XMMPIXPASA-N 0.000 claims description 2
- HMJIVODEQNCVSC-XMMPIXPASA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(5-pyridin-3-ylpyridin-3-yl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CN=CC(C3=CC=CN=C3)=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 HMJIVODEQNCVSC-XMMPIXPASA-N 0.000 claims description 2
- UNJNXDQOFPVKEH-HSZRJFAPSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-(6-propan-2-ylpyridin-2-yl)cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CC(C)C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=N1 UNJNXDQOFPVKEH-HSZRJFAPSA-N 0.000 claims description 2
- YDZAPLTZVUACLC-HHHXNRCGSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-(1-methyl-6-oxopyridin-3-yl)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CN(C=C(C=C1)C2=CC=CC(C3(CC3)C(N3)=NC(CCCN(C4)C([C@@H](C5=CC(C(F)(F)F)=CC=C5)O)=O)=C4C3=O)=C2)C1=O YDZAPLTZVUACLC-HHHXNRCGSA-N 0.000 claims description 2
- DUOIJFAWXPMTGU-RUZDIDTESA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-(1-methylpyrazol-3-yl)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CN(C=C1)N=C1C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 DUOIJFAWXPMTGU-RUZDIDTESA-N 0.000 claims description 2
- CBSDTRMYBOXANY-HHHXNRCGSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-(piperidin-1-ylmethyl)phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(CN3CCCCC3)=CC=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 CBSDTRMYBOXANY-HHHXNRCGSA-N 0.000 claims description 2
- ORFZPGRVHWMFIW-SSEXGKCCSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CN(CC1)CCC1N1N=CC(C2=CC=CC(C3(CC3)C(N3)=NC(CCCN(C4)C([C@@H](C5=CC(C(F)(F)F)=CC=C5)O)=O)=C4C3=O)=C2)=C1 ORFZPGRVHWMFIW-SSEXGKCCSA-N 0.000 claims description 2
- IKYYUVJFGYYSSJ-MGBGTMOVSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[4-(1-methylpiperidin-4-yl)phenyl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CN(CC1)CCC1C(C=C1)=CC=C1C1=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=CC=C1 IKYYUVJFGYYSSJ-MGBGTMOVSA-N 0.000 claims description 2
- YJDSJBCXFSEWNO-JGCGQSQUSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[4-(pyrrolidin-1-ylmethyl)phenyl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC(C3=CC=C(CN4CCCC4)C=C3)=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 YJDSJBCXFSEWNO-JGCGQSQUSA-N 0.000 claims description 2
- FLGPMPZUIRPWOU-MGBGTMOVSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CN1CCN(CC(C=C2)=CC=C2C2=CC(C3(CC3)C(N3)=NC(CCCN(C4)C([C@@H](C5=CC(C(F)(F)F)=CC=C5)O)=O)=C4C3=O)=CC=C2)CC1 FLGPMPZUIRPWOU-MGBGTMOVSA-N 0.000 claims description 2
- WTHDFGICXDFABN-WJOKGBTCSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[3-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]phenyl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CN(CC1)CCN1C(N=C1)=CC=C1C1=CC=CC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 WTHDFGICXDFABN-WJOKGBTCSA-N 0.000 claims description 2
- SDXBKONRQSHSNW-RUZDIDTESA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[4-(1-methylpiperidin-4-yl)thiophen-2-yl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound CN(CC1)CCC1C1=CSC(C2(CC2)C(N2)=NC(CCCN(C3)C([C@@H](C4=CC(C(F)(F)F)=CC=C4)O)=O)=C3C2=O)=C1 SDXBKONRQSHSNW-RUZDIDTESA-N 0.000 claims description 2
- LGRVVYWEWUZZFU-HHHXNRCGSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[4-(2-phenylethynyl)thiophen-2-yl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C#CC3=CC=CC=C3)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 LGRVVYWEWUZZFU-HHHXNRCGSA-N 0.000 claims description 2
- HPHFNIVMIFHSTB-HSZRJFAPSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[4-(oxan-4-yl)thiophen-2-yl]cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCOCC3)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 HPHFNIVMIFHSTB-HSZRJFAPSA-N 0.000 claims description 2
- OSDJPPZQEXWQRL-XMMPIXPASA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[4-(piperidine-1-carbonyl)thiophen-2-yl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C(N3CCCCC3)=O)=CS1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 OSDJPPZQEXWQRL-XMMPIXPASA-N 0.000 claims description 2
- CEXYVVVBVMYEDK-JOCHJYFZSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[5-(1,2-thiazol-4-yl)pyridin-3-yl]cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CSN=C3)=CN=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 CEXYVVVBVMYEDK-JOCHJYFZSA-N 0.000 claims description 2
- QCVHCXWEBTUKSC-HSZRJFAPSA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[5-(1,2-thiazol-4-yl)pyridin-3-yl]cyclopropyl]-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC(C3=CSN=C3)=CN=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 QCVHCXWEBTUKSC-HSZRJFAPSA-N 0.000 claims description 2
- LPGANCRASMFVAC-XMMPIXPASA-N 6-[(2R)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetyl]-2-[1-[5-(oxan-4-yl)pyridin-3-yl]cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(C3CCOCC3)=CN=C1)NC2=O)=O)C1=CC(C(F)(F)F)=CC=C1 LPGANCRASMFVAC-XMMPIXPASA-N 0.000 claims description 2
- SLTNMVXSYNVTGK-JGCGQSQUSA-N 6-[(2R)-2-hydroxy-2-[3-[4-(pyridin-2-ylmethoxy)phenyl]phenyl]acetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C(C=C2)=CC=C2OCC2=NC=CC=C2)=C1 SLTNMVXSYNVTGK-JGCGQSQUSA-N 0.000 claims description 2
- JQIPXAFEZLQBTN-XMMPIXPASA-N 6-[(2R)-2-hydroxy-2-naphthalen-2-ylacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC2=CC=CC=C2C=C1 JQIPXAFEZLQBTN-XMMPIXPASA-N 0.000 claims description 2
- AHEHEEVZWWNLIC-HXUWFJFHSA-N 6-[(2R)-2-hydroxy-2-phenylacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC=C1 AHEHEEVZWWNLIC-HXUWFJFHSA-N 0.000 claims description 2
- WFSRDMKOMKJCBZ-OAQYLSRUSA-N 6-[(2R)-2-hydroxy-3-phenylpropanoyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@H](CC1=CC=CC=C1)C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O WFSRDMKOMKJCBZ-OAQYLSRUSA-N 0.000 claims description 2
- PYJLPDSPPQAFNN-JOCHJYFZSA-N 6-[(2R)-2-hydroxy-4-phenylbutanoyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@H](CCC1=CC=CC=C1)C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O PYJLPDSPPQAFNN-JOCHJYFZSA-N 0.000 claims description 2
- YECPQQNZCNAUSU-FQEVSTJZSA-N 6-[(2S)-2-(2,3-difluorophenyl)-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C(C=CC=C1F)=C1F YECPQQNZCNAUSU-FQEVSTJZSA-N 0.000 claims description 2
- JVWQQPFMTCSKSD-SFHVURJKSA-N 6-[(2S)-2-(2,3-difluorophenyl)-2-hydroxyacetyl]-2-(1-thiophen-2-ylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CS1)NC2=O)=O)C(C=CC=C1F)=C1F JVWQQPFMTCSKSD-SFHVURJKSA-N 0.000 claims description 2
- IFLRGOZMZOYUCZ-FQEVSTJZSA-N 6-[(2S)-2-(2,3-difluorophenyl)-2-hydroxyacetyl]-2-[1-(3-fluorophenyl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC(F)=CC=C1)NC2=O)=O)C(C=CC=C1F)=C1F IFLRGOZMZOYUCZ-FQEVSTJZSA-N 0.000 claims description 2
- OHHDPJVZHMMHLG-FQEVSTJZSA-N 6-[(2S)-2-(2,3-difluorophenyl)-2-hydroxyacetyl]-2-[1-(4-fluorophenyl)cyclopropyl]-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@H](C(N(CC1)CC2=C1N=C(C1(CC1)C(C=C1)=CC=C1F)NC2=O)=O)C(C=CC=C1F)=C1F OHHDPJVZHMMHLG-FQEVSTJZSA-N 0.000 claims description 2
- OZTHTRMMCCVTFO-FQEVSTJZSA-N 6-[(2S)-2-(2-chlorophenyl)-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C(C=CC=C1)=C1Cl OZTHTRMMCCVTFO-FQEVSTJZSA-N 0.000 claims description 2
- VOMTYKMELDYRPU-SANMLTNESA-N 6-[(2S)-2-[3-(3-fluorophenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound O[C@H](C(N(CC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(F)=CC=C2)=C1 VOMTYKMELDYRPU-SANMLTNESA-N 0.000 claims description 2
- ZTACWODXHGVOBN-MHZLTWQESA-N 6-[(2S)-2-[3-(3-fluorophenyl)phenyl]-2-hydroxyacetyl]-2-(1-phenylcyclopropyl)-5,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4-one Chemical compound O[C@H](C(N(CCC1)CC2=C1N=C(C1(CC1)C1=CC=CC=C1)NC2=O)=O)C1=CC=CC(C2=CC(F)=CC=C2)=C1 ZTACWODXHGVOBN-MHZLTWQESA-N 0.000 claims description 2
- VEYQSTAXWJVYTN-FQEVSTJZSA-N 6-[(2S)-2-[4-(2-methylpropyl)phenyl]propanoyl]-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Chemical compound CC(C)CC1=CC=C([C@H](C)C(N(CC2)CC3=C2N=C(C2(CC2)C2=CC=CC=C2)NC3=O)=O)C=C1 VEYQSTAXWJVYTN-FQEVSTJZSA-N 0.000 claims description 2
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- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 description 1
- 239000003029 tricyclic antidepressant agent Substances 0.000 description 1
- 125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 210000000427 trigeminal ganglion Anatomy 0.000 description 1
- 206010044652 trigeminal neuralgia Diseases 0.000 description 1
- BPLUKJNHPBNVQL-UHFFFAOYSA-N triphenylarsine Chemical compound C1=CC=CC=C1[As](C=1C=CC=CC=1)C1=CC=CC=C1 BPLUKJNHPBNVQL-UHFFFAOYSA-N 0.000 description 1
- UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical compound ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 description 1
- 229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
- 235000019798 tripotassium phosphate Nutrition 0.000 description 1
- COIOYMYWGDAQPM-UHFFFAOYSA-N tris(2-methylphenyl)phosphane Chemical compound CC1=CC=CC=C1P(C=1C(=CC=CC=1)C)C1=CC=CC=C1C COIOYMYWGDAQPM-UHFFFAOYSA-N 0.000 description 1
- DLQYXUGCCKQSRJ-UHFFFAOYSA-N tris(furan-2-yl)phosphane Chemical compound C1=COC(P(C=2OC=CC=2)C=2OC=CC=2)=C1 DLQYXUGCCKQSRJ-UHFFFAOYSA-N 0.000 description 1
- 238000001946 ultra-performance liquid chromatography-mass spectrometry Methods 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 125000005500 uronium group Chemical group 0.000 description 1
- BDIAUFOIMFAIPU-UHFFFAOYSA-N valepotriate Natural products CC(C)CC(=O)OC1C=C(C(=COC2OC(=O)CC(C)C)COC(C)=O)C2C11CO1 BDIAUFOIMFAIPU-UHFFFAOYSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000006492 vascular dysfunction Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 208000009935 visceral pain Diseases 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
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- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Abstract
Description
{PL2} WO2018055527
{PL3} WO2018055526
{PL4} WO2018055524
{PL5} WO2013012500
{PL6} WO2012174342
{PL7} WO2012174340
{PL8} WO2011119701
{PL9} WO2013146754
{PL10} WO2015046193
{NPL2} Watanabe, H., et al., Nature, 2003, 424, 434-438
{NPL3} Watanabe, H., et al., J Biol Chem, 2002, 277, 47044-47051
{NPL4} Watanabe, H., et al., J Biol Chem, 2002, 277, 13569-13577
{NPL5} Tadaka, H., et al., J Biol Chem, 2004, 279, 35133-35138
{NPL6} Lee, H., et al., J Neurosci, 2005, 25, 1304-1310
{NPL7} Alessandri-Haber, N., et al., J Neurosci, 2006, 26, 3864-3874
{NPL8} Alessandri-Haber, N., et al., J Neurosci, 2004, 24, 4444-4452
{NPL9} Alessandri-Haber, N., et al., J Neurosci, 2008, 28, 1046-1057
{NPL10} Cenac, N., et al., Gastroenterology, 2008, 135, 937-946
{NPL11} Everaerts, W., et al., Proc Natl Acad Sci USA, 2010, 107, 19084-19089
{NPL12} Mizuno, N., et al., Am J Physiol Cell Physiol, 2003, 285, C96-101
{NPL13} Koehler, R., et al. Arterioscler Thromb Vasc Biol, 2006, 26, 1495-1502
{NPL14} Gevaert, T., et al., J Clin Invest, 2007, 117, 3453-3462
{NPL15} Thorneloe, K.S., et al. J Pharmacol Exp Ther, 2008, 326, 432-442
{NPL16} Masuyama, R., et al., Cell Metab, 2008, 8, 257-265
{NPL17} Cortright, D.N., et al., Curr Pharm Des, 2009, 15, 1736-1749
{NPL18} Jia, Y. et al., Biochim Biophys Acta, 2007, 1772, 915-927
{NPL19} Inoue, R., et al., Pharmacol Ther, 2009, 123, 371-385
{NPL20} Hsu, Y.J., et al., Biochim Biophys Acta, 2007, 1772, 928-936
{NPL21} Casas, S., et al., Diabetologia, 2008, 51, 2252-2562
{NPL22} Brierley, S.M., et al., Gastroenterology, 2008, 134, 2059-2069
[1] A compound of the following formula (I):
R1 and R2 are independently selected from the group consisting of: hydrogen, hydroxyl, halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxyl, (C1-C6)haloalkoxy, (C3-C7)cycloalkyl, and phenyl(C0-C4)alkyl; wherein the said (C3-C7)cycloalkyl or phenyl(C0-C4)alkyl is optionally substituted with 1 to 4 substituents independently selected from the group consisting of: halogen, hydroxyl, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, and (C1-C6)haloalkoxy; or alternatively R1 and R2, together with the atom to which they are attached, may form a 3 to 8 membered ring which may contain 0 to 4 heteroatoms independently selected from oxygen, sulfur, and nitrogen; wherein the said 3 to 8 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, (C1-C6)alkyl, (C1-C6)haloalkyl, -SO2(C1-C6)alkyl, -SO2(C1-C6)haloalkyl, -C(=O)( C1-C6)alkyl, and -C(=O)(C1-C6)haloalkyl; preferably R1 and R2 are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxyl, (C1-C6)haloalkoxy, and (C3-C7)cycloalkyl; or alternatively R1 and R2, together with the atom to which they are attached, may form a 3 to 8 membered carbon ring;
R3 is independently selected from the group consisting of: hydrogen, fluoride, methyl, ethyl, and (C1-C6)haloalkyl; preferably R3 is independently selected from the group consisting of: hydrogen, fluoride, and methyl;
X is selected from the group consisting of: a chemical bond, -N(R4)-, -(C(R5)(R6))n-, -(C3-C8)cycloalkyl-, -C(R5)=C(R6)-, -C(=O)-, -CR4(N(R5)(R6))-, -[(C(R5)(R6))nO]-, -[(C(R5)(R6))nN(R4)]-, -[(C(R5)(R6))nS]-, and -[N(R4)(C(R5)(R6))n]-; preferably X is selected from the group consisting of: a chemical bond, -(C(R5)(R6)-(CH2) m)-, -(C3-C8)cycloalkyl-, -CH=CH-, and -CH2O-; m is 0, 1, 2, or 3; more preferably X is selected from the group consisting of: a chemical bond, -C(R5)(R6)CH2-, -C(R5)(R6)-, -cyclopropyl-, -CH=CH-, and -CH2O-; further more preferably X is selected from the group consisting of: a chemical bond, -CH2-, -CF2-, -CH2CH2-, -CH(OH)-, and -CH(Me)-;
R4 is hydrogen or (C1-C6) alkyl;
R5 and R6 are independently selected from the group consisting of: hydrogen, halogen, hydroxyl, (C1-C6)alkyl, (C1-C6)alkoxy, hydroxyl(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)haloalkyl, and (C1-C6)haloalkoxy; preferably R5 and R6 are independently selected from the group consisting of: hydrogen, halogen, hydroxyl, and (C1-C6)alkyl; more preferably R5 and R6 are independently selected from the group consisting of: hydrogen, fluorine, hydroxyl, and methyl;
when R5 is two or more than two, R5 is same or different;
when R6 is two or more than two, R6 is same or different;
n is 1, 2, 3, or 4; preferably n is 1 or 2;
q is 1, 2, 3, or 4; preferably q is 1 or 2;
r is 1, 2, 3, or 4; preferably r is 1 or 2;
s is 1, 2, 3, or 4; preferably s is 1 or 2;
Ar1 is selected from aryl and heteroaryl which are optionally substituted with 1 to 6 substituents independently selected from the group consisting of: hydrogen, halogen, cyano, nitro, hydroxyl, -C(=O)R7, -C(=O)NR7R8, -NHSO2R7, -SO2NR7R8, (C1-C6)alkylthio-, (C1-C6)haloalkylthio-, (C1-C6)alkylsulfinyl, (C1-C6)alkylsulfonyl, -NR7R8, tri(C1-C6)alkylsilyl, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C1-C6)alkoxy, (C1-C6)alkenyl, aryl(C0-C4)alkyl, heteroaryl(C0-C4)alkyl, aryl(C0-C6)alkoxy, heterocyclyl(C0-C4)alkyl, heterocyclyl(C0-C6)alkoxy, heteroaryl(C0-C6)alkoxy and substituent group Q; wherein the said (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C1-C6)alkoxy, (C1-C6)alkenyl, aryl(C0-C4)alkyl, heteroaryl(C0-C4)alkyl, aryl(C0-C6)alkoxy, heterocyclyl(C0-C4)alkyl, heterocyclyl(C0-C6)alkoxy, or heteroaryl(C0-C6)alkoxy is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, cyano, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkoxy, (C1-C6)haloalkoxy, phenyl, -NRaRb, RaRbN(C1-C6)alkyl, RaRbN(C1-C6)alkoxy, -C(=O)NRaRb, -C(=O)Ra, -SO2(C1-C6)alkyl, -SO2NRaRb, and RaRbNC(=O)(C1-C6)alkoxy; wherein the said (C3-C7)cycloalkyl is optionally substituted with hydroxyl or cyano; wherein the substituent group Q is
preferably aryl is phenyl or naphthyl, and preferably heteroaryl is unsaturated or partially saturated mono- or bi-cyclic 5 to 15-membered ring with 1-4 heteroatoms independently selected from O, N, and S, or carbonyl; more preferably aryl is phenyl and more preferably heteroaryl is 5 to 6-membered ring with 1-4 heteroatoms independently selected from O, N, and S, or 9 to 10-membered heteroaromatic ring with 1-4 heteroatoms independently selected from O, N, and S; further more preferably aryl is phenyl and further more preferably heteroaryl is 5 to 6-membered heteroaromatic ring with 1-4 heteroatoms independently selected from O, N, and S; further more preferably heteroaryl is pyridiyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, furanyl, thiophenyl, imidazolyl, pyrazolyl, oxazolyl, isooxazolyl, thiazolyl, isothiazolyl, indolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, imidazonyridinyl, indazolyl, oxadiazolyl, benzoisoxazolyl, quinazolinyl, quinoxalinyl, quinolinyl, or isoquinolinyl;
R7 and R8 are independently selected from the group consisting of: hydrogen, hydroxyl, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C1-C6)haloalkoxyl, (C3-C7)cycloalkyl, heterocyclyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)haloalkoxy(C1-C6)alkyl, benzyl, H2N(C1-C6)alkyl, (C1-C6)alkylNH(C1-C6)alkyl, and [(C1-C6)alkyl]2N(C1-C6)alkyl; or R7 and R8, together with nitrogen atom to which they are attached, may form a 3 to 10 membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen; wherein the said 3 to 10 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, oxo, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, -SO2(C1-C6)alkyl, -SO2(C1-C6)haloalkyl, -C(=O)(C1-C6)alkyl, and -C(=O) (C1-C6)haloalkyl;
Ra and Rb are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, (C3-C7)cycloalkyl, phenyl(C0-C6)alkyl, (C1-C6)haloalkoxy(C1-C6)alkyl, H2N(C1-C6)alkyl, (C1-C6)alkylNH(C1-C6)alkyl, and [(C1-C6)alkyl]2N(C1-C6)alkyl; or Ra and Rb, together with nitrogen atom to which they are attached, may form a 3 to 7 membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen; wherein the said 3 to 7 membered ring is optionally substituted with 1 to 3 substituents independently selected from (C1-C6)alkyl;
Ar2 is selected from aryl and heteroaryl which are optionally substituted with 1 to 6 substituents independently selected from the group consisting of: hydrogen, halogen, cyano, nitro, hydroxyl, -COR9, -CONR9R10, -NHSO2R9, -SO2NR9R10, (C1-C6)alkylthio-, (C1-C6)alkylsulfinyl, (C1-C6)alkylsulfonyl, -NR9R10, tri(C1-C6)alkylsilyl, (C1-C6)haloalkylthio-, -SF5, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C1-C6)alkoxy, aryl(C0-C4)alkyl, heteroaryl(C0-C4)alkyl, aryl(C0-C6)alkoxy, phenoxy, heteroaryl(C0-C6)alkoxy, heterocyclyl(C0-C4)alkyl, and heterocyclyl(C0-C6)alkoxy; wherein the said (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C1-C6)alkoxy, aryl(C0-C4)alkyl, heteroaryl(C0-C4)alkyl, aryl(C0-C6)alkoxy, phenoxy, heteroaryl(C0-C6)alkoxy, heterocyclyl(C0-C4)alkyl, or heterocyclyl(C0-C6)alkoxy is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, (C1-C6)alkyl, (C3-C7)cycloalkyl (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C6)alkoxy(C1-C6)alkoxy, (C1-C6)haloalkoxy, -NRcRd, RcRdN(C1-C6)alkyl, RcRdN(C1-C6)alkoxy, -C(=O)NRcRd, RcRdNC(=O)(C1-C6)alkoxy, benzyloxy, and cyano; preferably aryl is phenyl or naphthyl, and preferably heteroaryl is unsaturated or partially saturated mono- or bi-cyclic 5 to 15-membered ring with 1-4 heteroatoms independently selected from O, N, and S, or carbonyl; more preferably aryl is phenyl and more preferably heteroaryl is 5 to 6-membered ring with 1-4 heteroatoms independently selected from O, N, and S, or 9 to 10-membered heteroaromatic ring with 1-4 heteroatoms independently selected from O, N, and S; further more preferably aryl is phenyl and further more preferably heteroaryl is 5 to 6-membered heteroaromatic ring with 1-4 heteroatoms independently selected from O, N, and S; further more preferably heteroaryl is pyridiyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, furanyl, thiophenyl, imidazolyl, pyrazolyl, oxazolyl, isooxazolyl, thiazolyl, isothiazolyl, indolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, imidazonyridinyl, indazolyl, oxadiazolyl, benzoisoxazolyl, quinazolinyl, quinoxalinyl, quinolinyl, or isoquinolinyl;
R9 and R10 are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)haloalkoxy(C1-C6)alkyl, H2N(C1-C6)alkyl, (C1-C6)alkylNH(C1-C6)alkyl, and [(C1-C6)alkyl]2N(C1-C6)alkyl; or R9 and R10, together with nitrogen atom to which they are attached, may form a 3 to 10 membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen; wherein the said 3 to 10 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, oxo, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, -SO2(C1-C6)alkyl, -SO2(C1-C6)haloalkyl, -C(=O)(C1-C6)alkyl, and -C(=O)(C1-C6)haloalkyl; and
Rc and Rd are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)haloalkoxy(C1-C6)alkyl, H2N(C1-C6)alkyl, (C1-C6)alkylNH(C1-C6)alkyl, and [(C1-C6)alkyl]2N(C1-C6)alkyl; or Rc and Rd, together with nitrogen atom to which they are attached, may form a 3 to 7 membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen;
or a pharmaceutically acceptable salt thereof;
R1 and R2 are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxyl, (C1-C6)haloalkoxy, and (C3-C7)cycloalkyl; or alternatively R1 and R2, together with the atom to which they are attached, may form a 3 to 8 membered carbon ring;
X is selected from the group consisting of: a chemical bond, -(C(R5)(R6)-(CH2)m)-, -(C3-C8)cycloalkyl-, -CH=CH-, and -CH2O-;
m is 0, 1, 2, or 3; and
R5 and R6 are independently selected from the group consisting of: hydrogen, halogen, hydroxyl, and (C1-C6)alkyl;
or a pharmaceutically acceptable salt thereof;
R1 and R2 are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxyl, (C1-C6)haloalkoxy, and (C3-C7)cycloalkyl; or alternatively R1 and R2, together with the atom to which they are attached, may form a 3 to 8 membered carbon ring;
X is selected from the group consisting of: a chemical bond and -CR5R6-;
R5 and R6 are independently selected from the group consisting of: hydrogen, halogen, hydroxyl, (C1-C6)alkyl, and (C1-C6)alkoxy;
q is 1, 2, or 3;
r is 1, 2, or 3;
s is 1, 2, or 3;
Ar1 is selected from aryl and heteroaryl which are optionally substituted with 1 to 6 substituents independently selected from the group consisting of: hydrogen, halogen, hydroxyl, cyano, -C(=O)R7, -C(=O)NR7R8, -NR7R8, -NHSO2R7, -SO2NR7R8, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkoxy, phenyl, heteroaryl, phenoxy, and heterocyclyl; wherein the said (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkoxy, phenyl, heteroaryl, phenoxy, or heterocyclyl is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, cyano, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, -NRaRb, -C(=O)NRaRb, -C(=O)Ra;
R7 and R8 are independently selected from the group consisting of: hydrogen, hydroxyl, (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C7)cycloalkyl; or R7 and R8, together with nitrogen atom to which they are attached, may form a 3 to 7 membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen; wherein the said 3 to 7 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, (C1-C6)alkyl, (C1-C6)alkoxy, and (C1-C6)haloalkyl;
Ra and Rb are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C7)cycloalkyl; or Ra and Rb, together with nitrogen atom to which they are attached, may form a 3 to 7 membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen; wherein the said 3 to 7 membered ring is optionally substituted with 1 to 3 substituents independently selected from methyl and ethyl;
Ar2 is selected from aryl and heteroaryl which are optionally substituted with 1 to 6 substituents independently selected from the group consisting of: hydrogen, halogen, hydroxyl, cyano, -COR9, -CONR9R10, -NHSO2R9, -SO2NR9R10, -NR9R10, (C1-C6)haloalkylthio-, -SF5, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C1-C6)alkoxy, phenyl, heteroaryl, phenoxy, and heterocyclyl; wherein the said (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C1-C6)alkoxy, phenyl, heteroaryl, phenoxy, or heterocyclyl is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, (C1-C6)alkyl, (C3-C7)cycloalkyl (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C6)haloalkoxy, -NRcRd, and -C(=O)NRcRd;
Rc and Rd are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, and hydroxy(C1-C6)alkyl; or Rc and Rd, together with nitrogen atom to which they are attached, may form a 3 to 7 membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen;
or a pharmaceutically acceptable salt thereof;
R1 and R2 are independently selected from the group consisting of: hydrogen, methyl, and ethyl; or alternatively R1 and R2, together with the atom to which they are attached, may form a 3 to 6 membered carbon ring;
Ar1 is selected from aryl and heteroaryl which are optionally substituted with 1 to 6 substituents independently selected from the group consisting of: hydrogen, halogen, hydroxyl, cyano, -C(=O)R7, -C(=O)NR7R8, -NR7R8, -NHSO2R7, -SO2NR7R8, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkoxy, phenyl, naphthyl, phenoxy, pyridiyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, furanyl, benzofuranyl, thiophenyl, benzothiophenyl, imidazolyl, benzimidazole, indole, pyrazolyl, oxazolyl, isooxazolyl, thiazolyl, isothiazolyl, phenoxy, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, azetidinyl, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, and aziridinyl; wherein the said (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkoxy, phenyl, phenoxy, pyridiyl, pyrimidinyl, pyridazinyl, pyrazinyl, imidazolyl, pyrazolyl, furanyl, benzofuranyl, thiophenyl, benzothiophenyl, imidazolyl, benzimidazole, indole, pyrazolyl, oxazolyl, isooxazolyl, thiazolyl, isothiazolyl, phenoxy, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, azetidinyl, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, and aziridinyl; is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, cyano, (C1-C6)alkyl, and (C1-C6)haloalkyl;
wherein the said aryl is phenyl or naphthyl;
wherein the said heteroaryl is pyridiyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, furanyl, thiophenyl, imidazolyl, pyrazolyl, oxazolyl, isooxazolyl, thiazolyl, isothiazolyl, indolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, imidazonyridinyl, indazolyl, oxadiazolyl, benzoisoxazolyl, quinazolinyl, quinoxalinyl, quinolinyl or isoquinolinyl;
R7 and R8 are independently selected from the group consisting of: hydrogen, hydroxyl, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C1-C6)haloalkoxyl, and (C3-C7)cycloalkyl;
Ar2 is selected from aryl and heteroaryl which are optionally substituted with 1 to 6 substituents independently selected from the group consisting of: hydrogen, halogen, hydroxyl, cyano, -SCF3, SF5, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C6)haloalkoxy, phenyl, naphthyl, phenoxy, pyridyl, oxazolyl, pyridazinyl, pyrazinyl, pyrrolyl, benzothiophenyl, furanyl, benzofuranyl, quinolinyl, isoquinolinyl, thiophenyl, pyrimidinyl, pyrazolyl, imidazolyl, benzimidazole, and indole; wherein the said phenyl, naphthyl, phenoxy, pyridyl, oxazolyl, pyridazinyl, pyrazinyl, pyrrolyl, benzothiophenyl, furanyl, benzofuranyl, quinolinyl, isoquinolinyl, thiophenyl, pyrimidinyl, pyrazolyl, imidazolyl, benzimidazole, or indole is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: hydrogen, halogen, hydroxyl, cyano, -SCF3, SF5, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, and (C1-C6)haloalkoxy;
wherein the said aryl is phenyl or naphthyl;
wherein the said heteroaryl is pyridiyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, furanyl, thiophenyl, imidazolyl, pyrazolyl, oxazolyl, isooxazolyl, thiazolyl, isothiazolyl, indolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, imidazonyridinyl, indazolyl, oxadiazolyl, benzoisoxazolyl, quinazolinyl, quinoxalinyl, quinolinyl or isoquinolinyl;
or a pharmaceutically acceptable salt thereof;
R1 and R2 are independently selected from the group consisting of: hydrogen, hydroxyl, halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxyl, (C1-C6)haloalkoxy, (C3-C7)cycloalkyl, and phenyl(C0-C4)alkyl; wherein the said (C3-C7)cycloalkyl or phenyl(C0-C4)alkyl is optionally substituted with 1 to 4 substituents independently selected from the group consisting of: halogen, hydroxyl, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, and (C1-C6)haloalkoxy; or alternatively R1 and R2, together with the atom to which they are attached, may form a 3 to 8 membered carbon ring; the said 3 to 8 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, (C1-C6)alkyl, (C1-C6)haloalkyl, -SO2(C1-C6)alkyl, -SO2(C1-C6)haloalkyl, -C(=O)(C1-C6)alkyl, and -C(=O)(C1-C6)haloalkyl; preferably R1 and R2 are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxyl, (C1-C6)haloalkoxy, and (C3-C7)cycloalkyl; or alternatively R1 and R2, together with the atom to which they are attached, may form a 3 to 8 membered carbon ring;
R3 is independently selected from the group consisting of: hydrogen, fluoride, methyl, ethyl, and (C1-C6)haloalkyl; preferably R3 is independently selected from the group consisting of: hydrogen, fluoride, and methyl;
q is 1, 2, 3, or 4; preferably q is 1 or 2;
r is 1, 2, 3, or 4; preferably r is 1 or 2;
s is 1, 2, 3, or 4; preferably s is 1 or 2;
Ar1 is selected from aryl and heteroaryl which are optionally substituted with 1 to 6 substituents independently selected from the group consisting of: hydrogen, halogen, cyano, nitro, hydroxyl, -C(=O)R7, -C(=O)NR7R8, -NHSO2R7, -SO2NR7R8, (C1-C6)alkylthio-, (C1-C6)haloalkylthio-, (C1-C6)alkylsulfinyl, (C1-C6)alkylsulfonyl, -NR7R8, tri(C1-C6)alkylsilyl, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C1-C6)alkoxy, (C1-C6)alkenyl, aryl(C0-C4)alkyl, heteroaryl(C0-C4)alkyl, aryl(C0-C6)alkoxy, heterocyclyl(C0-C4)alkyl, heterocyclyl(C0-C6)alkoxy, heteroaryl(C0-C6)alkoxy and substituent group Q; wherein the said (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C1-C6)alkoxy, (C1-C6)alkenyl, aryl(C0-C4)alkyl, heteroaryl(C0-C4)alkyl, aryl(C0-C6)alkoxy, heterocyclyl(C0-C4)alkyl, heterocyclyl(C0-C6)alkoxy, or heteroaryl(C0-C6)alkoxy is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, cyano, (C1-C6)alkyl, (C3-C7)cycloalkyl (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkoxy, (C1-C6)haloalkoxy, phenyl, -NRaRb, RaRbN(C1-C6)alkyl, RaRbN(C1-C6)alkoxy, -C(=O)NRaRb, -C(=O)Ra, -SO2(C1-C6)alkyl, -SO2NRaRb, and RaRbNC(=O)(C1-C6)alkoxy; wherein the said (C3-C7)cycloalkyl is optionally substituted with hydroxyl or cyano; wherein the substituent group Q is
preferably aryl is phenyl or naphthyl, and preferably heteroaryl is unsaturated or partially saturated mono- or bi-cyclic 5 to 15-membered ring with 1-4 heteroatoms independently selected from O, N, and S, or carbonyl; more preferably aryl is phenyl and more preferably heteroaryl is 5 to 6-membered ring with 1-4 heteroatoms independently selected from O, N, and S, or 9 to 10-membered heteroaromatic ring with 1-4 heteroatoms independently selected from O, N, and S; further more preferably aryl is phenyl and further more preferably heteroaryl is 5 to 6-membered heteroaromatic ring with 1-4 heteroatoms independently selected from O, N, and S; further more preferably heteroaryl is pyridiyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, furanyl, thiophenyl, imidazolyl, pyrazolyl, oxazolyl, isooxazolyl, thiazolyl, isothiazolyl, indolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, imidazonyridinyl, indazolyl, oxadiazolyl, benzoisoxazolyl, quinazolinyl, quinoxalinyl, quinolinyl, or isoquinolinyl;
R7 and R8 are independently selected from the group consisting of: hydrogen, hydroxyl, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C3-C7)cycloalkyl, heterocyclyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)haloalkoxy(C1-C6)alkyl, benzyl, H2N(C1-C6)alkyl, (C1-C6)alkylNH(C1-C6)alkyl, and [(C1-C6)alkyl]2N(C1-C6)alkyl; or R7 and R8, together with nitrogen atom to which they are attached, may form a 3 to 10 membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen; the said 3 to 10 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, oxo, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, -SO2(C1-C6)alkyl, -SO2(C1-C6)haloalkyl, -C(=O)(C1-C6)alkyl, and -C(=O)(C1-C6)haloalkyl;
Ra and Rb are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, (C3-C7)cycloalkyl, phenyl(C0-C6)alkyl, (C1-C6)haloalkoxy(C1-C6)alkyl, H2N(C1-C6)alkyl, (C1-C6)alkylNH(C1-C6)alkyl, and [(C1-C6)alkyl]2N(C1-C6)alkyl; or Ra and Rb, together with nitrogen atom to which they are attached, may form a 3 to 7 membered ring which may contain an atom selected from oxygen, sulfur, and nitrogen; wherein the said 3 to 7 membered ring is optionally substituted with 1 to 3 substituents independently selected from (C1-C6)alkyl;
Ar2 is selected from aryl and heteroaryl which are optionally substituted with 1 to 6 substituents independently selected from the group consisting of: hydrogen, halogen, cyano, nitro, hydroxyl, -COR9, -CONR9R10, -NHSO2R9, -SO2NR9R10, (C1-C6)alkylthio, (C1-C6)alkylsulfinyl, (C1-C6)alkylsulfonyl, -NR9R10, tri(C1-C6)alkylsilyl, C1-C6)haloalkylthio-, -SF5, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C1-C6)alkoxy, aryl(C0-C4)alkyl, heteroaryl(C0-C4)alkyl, aryl(C0-C6)alkoxy, phenoxy, heteroaryl(C0-C6)alkoxy, heterocyclyl(C0-C4)alkyl, and heterocyclyl(C0-C6)alkoxy; wherein the said (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C1-C6)alkoxy, aryl(C0-C4)alkyl, heteroaryl(C0-C4)alkyl, aryl(C0-C6)alkoxy, phenoxy, heteroaryl(C0-C6)alkoxy, heterocyclyl(C0-C4)alkyl, or heterocyclyl(C0-C6)alkoxy is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, (C1-C6)alkyl, (C3-C7)cycloalkyl (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C6)alkoxy(C1-C6)alkoxy, (C1-C6)haloalkoxy, -NRcRdN, RcRdN(C1-C6)alkyl, RcRdN(C1-C6)alkoxy, -C(=O)NRcRd, RcRdNC(=O)(C1-C6)alkoxy, benzyloxy, and cyano; preferably aryl is phenyl or naphthyl, and preferably heteroaryl is unsaturated or partially saturated mono- or bi-cyclic 5 to 15-membered ring with 1-4 heteroatoms independently selected from O, N, and S, or carbonyl; more preferably aryl is phenyl and more preferably heteroaryl is 5 to 6-membered ring with 1-4 heteroatoms independently selected from O, N, and S, or 9 to 10-membered heteroaromatic ring with 1-4 heteroatoms independently selected from O, N, and S; further more preferably aryl is phenyl and further more preferably heteroaryl is 5 to 6-membered heteroaromatic ring with 1-4 heteroatoms independently selected from O, N, and S; further more preferably heteroaryl is pyridiyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, furanyl, thiophenyl, imidazolyl, pyrazolyl, oxazolyl, isooxazolyl, thiazolyl, isothiazolyl, indolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, imidazonyridinyl, indazolyl, oxadiazolyl, benzoisoxazolyl, quinazolinyl, quinoxalinyl, quinolinyl, or isoquinolinyl;
R9 and R10 are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)haloalkoxy(C1-C6)alkyl, H2N(C1-C6)alkyl, (C1-C6)alkylNH(C1-C6)alkyl, and [(C1-C6)alkyl]2N(C1-C6)alkyl; or R9 and R10, together with nitrogen atom to which they are attached, may form a 3 to 10 membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen; wherein the said 3 to 10 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, oxo, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, -SO2(C1-C6)alkyl, -SO2(C1-C6)haloalkyl, -C(=O)(C1-C6)alkyl, and -C(=O)(C1-C6)haloalkyl; and
Rc and Rd are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)haloalkoxy(C1-C6)alkyl, H2N(C1-C6)alkyl, (C1-C6)alkylNH(C1-C6)alkyl, and [(C1-C6)alkyl]2N(C1-C6)alkyl; or Rc and Rd, together with nitrogen atom to which they are attached, may form a 3 to 7 membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen;
or a pharmaceutically acceptable salt thereof;
(R)-2-(1-phenylcyclopropyl)-6-(2-phenylpropanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-2-(1-phenylcyclopropyl)-6-(2-phenylpropanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4-isobutylphenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-6-(2-(4-isobutylphenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-fluorophenyl)cyclopropyl)-6-(2-(4-isobutylphenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(4-isobutylphenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-chlorophenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(4-(trifluoromethyl)phenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-fluorophenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-isopropylphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)propanoyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-(tert-butyl)phenoxy)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(1H-indol-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(5-fluoro-1H-indol-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(benzo[d]isoxazol-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(5-methyl-2-phenyloxazol-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(3-(3-phenyl-1,2,4-oxadiazol-5-yl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(quinoxalin-6-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2,2-difluoro-2-phenylacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-fluoro-2-phenylacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(5-chloro-1H-benzo[d]imidazol-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-hydroxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-methoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(3-(1H-indol-3-yl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(3-(3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(1H-indazol-1-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
4-(2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one;
(E)-6-(3-(3-chlorophenyl)acryloyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-((1R*,2R*)-2-phenylcyclopropane-1-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-((1R*,2R*)-2-(2,5-difluorophenyl)cyclopropane-1-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-phenylacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-(-)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-(+)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-(-)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-(+)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-(-)-2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-(-)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(-)-2-(1-(4-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(m-tolyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(-)-2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(m-tolyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-6-(2-hydroxy-2-phenylacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,4-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,4-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,6-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-3-phenylpropanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-4-phenylbutanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-fluoro-4-methoxyphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(6-methylpyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-fluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-fluoro-4-methoxyphenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(4-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-(trifluoromethyl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-(trifluoromethyl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(trifluoromethyl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(trifluoromethyl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(naphthalen-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-methoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(m-tolyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-4-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-2-yl)cyclopropyl)benzonitrile;
4-(1-(6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-4-oxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-2-yl)cyclopropyl)benzonitrile;
(S)-2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-hydroxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-bromo-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(p-tolyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(p-tolyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-isopropoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(2-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(2-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(cyclopentyloxy)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3,5-difluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3,5-difluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3,4-difluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3,4-difluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(trifluoromethoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-dichlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3-dichlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(2,2,2-trifluoroethoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-methoxyphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(4-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(m-tolyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(6-methylpyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(oxazol-5-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
3-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)ethyl)benzonitrile;
6-(2-hydroxy-2-(3-(pyrimidin-5-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(2-methoxypyrimidin-5-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(1,3-dimethyl-1H-pyrazol-4-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(oxazol-5-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pyridin-3-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(oxazol-5-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-fluoro-3-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)ethyl)benzonitrile;
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(pyridin-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-benzylcyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-benzylcyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(m-tolyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(2-methylthiazol-4-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiazol-4-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiazol-4-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiazol-5-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiazol-5-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(5-methylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-methylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-methylthiazol-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-methylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-((R)-2-(3-chlorophenyl)-2-hydroxyacetyl)-2-((R/S)-1-phenylethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclobutyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclobutyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclobutyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclobutyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
7-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-d]azepin-4-one;
(R)-7-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-d]azepin-4-one;
(R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7-tetrahydro-4H-pyrrolo[3,4-d]pyrimidin-4-one;
(R)-7-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one;
7-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-8-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
(R)-8-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
6-(2-hydroxy-2-(2-(pyrrolidin-1-yl)pyridin-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(2-(piperidin-1-yl)pyridin-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-(azepan-1-yl)pyridin-4-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-5-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-2-yl)cyclopropyl)thiophene-3-carbonitrile;
4-oxo-2-(1-phenylcyclopropyl)-N-(3-(trifluoromethyl)phenyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-6(4H)-carboxamide;
6-(1H-benzo[d]imidazole-2-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(5,6-difluoro-1H-benzo[d]imidazole-2-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(5,6-difluoro-1H-benzo[d]imidazole-2-carbonyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-benzyl-6-(5,6-difluoro-1H-benzo[d]imidazole-2-carbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(5-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-5-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-isopropylphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(pyridin-4-yl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(pyridin-3-yl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-chloro-3-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-(benzyloxy)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(tetrahydro-2H-pyran-4-yl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(1-methyl-1H-pyrazol-4-yl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(4-hydroxy-2-naphthoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(2-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3-dihydrobenzofuran-7-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-methylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-4-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2,4-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(3-(1H-indol-1-yl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(5-chlorothiophen-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-cyclopropylphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(4-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-chlorophenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chlorophenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(3-hydroxy-3-phenylpropanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(difluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-(tert-butyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3,5-dichlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-(1H-pyrazol-4-yl)thiophen-2-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(5-(trifluoromethyl)pyridin-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-5-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(naphthalen-1-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(naphthalen-1-ylmethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(naphthalen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-8-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
(R)-8-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
(R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(6-(trifluoromethyl)pyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(2-(trifluoromethyl)pyridin-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(6-chloro-1H-indole-2-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(5-(trifluoromethyl)-1H-benzo[d]imidazole-2-carbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(3-(2-fluorophenyl)-1H-pyrazole-5-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-chlorophenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(3-(2-chlorophenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-chlorophenoxy)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(2-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(3-(3-chlorophenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chlorophenoxy)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-chloro-3-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-3-(o-tolyloxy)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,4-dichlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-acetylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-ethylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-bromothiophen-2-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(6-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-methylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,5-dichlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(p-tolyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-isopropylphenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(difluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-phenylcyclopropyl)-6-(2-(4-(trifluoromethoxy)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-methoxyphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-chlorothiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-chlorothiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-bromophenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-([1,1'-biphenyl]-4-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(naphthalen-1-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-methylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(2-methylpyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(quinolin-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(4-(pyridin-2-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(3-(trifluoromethoxy)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-([1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(5-methylpyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(4-methylpyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(6-methoxypyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(4'-methyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(2-methylpyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(2-methylpyrimidin-5-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(6-(dimethylamino)pyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(5-chlorothiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-isopropylphenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-isopropylphenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-isopropylphenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(2-phenylpyridin-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-cyclopropylphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(1-methyl-1H-indol-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-ethylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(2-methyl-3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-chloro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-fluoro-5-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-5-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-cycloheptylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(2'-(trifluoromethyl)-[2,4'-bipyridin]-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3'-methyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(5-chlorothiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-methyl-5-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-methoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(4'-methoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
3'-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile;
6-(2-(4'-ethoxy-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(4'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(2'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(5,6-dimethylpyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-(difluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(5-bromopyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(prop-1-en-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-ethylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-(1-acetylpiperidin-4-yl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(4,4-difluorocyclohexyl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(6-chloropyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(6-(3-(trifluoromethyl)phenyl)pyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(2'-(trifluoromethyl)-[2,4'-bipyridin]-6-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(6-(3-chlorophenyl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(6-(3-(trifluoromethoxy)phenyl)pyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(piperidin-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(1-methylpiperidin-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-isopropylpyridin-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-((dimethylamino)methyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-acetylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-methoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(1H-benzo[d]imidazole-2-carbonyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(6-(cyclohex-1-en-1-yl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(2,2,2-trifluoroethoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(1'-methyl-1',2',3',6'-tetrahydro-[2,4'-bipyridin]-6-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(6-cyclohexylpyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(2,2,2-trifluoroethoxy)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(6-isopropylpyridin-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-phenylcyclopropyl)-6-(2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-amino-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(2-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-methyl-2-(3-(trifluoromethyl)phenyl)propanoyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-hydroxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3'-((trifluoromethyl)thio)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(2'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(thiazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(3-methoxypropyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenethylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(6-(3-(tert-butyl)phenyl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(6-(3-cyclopropylphenyl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-phenylcyclopropyl)-6-(1-(3-(trifluoromethyl)phenyl)cyclopropane-1-carbonyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)propanoyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(tetrahydro-2H-pyran-4-yl)ethyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-(2-cyclopropylethyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyrimidin-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(trifluoromethyl)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1,1,1-trifluoropropan-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isobutylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(4,4-dimethylcyclohexyl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(3-hydroxy-3-methylbutyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-(3,3-dimethylbutyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N-benzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide;
(R)-N-benzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-dimethylthiophene-3-carboxamide;
1-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)-2-(3-(trifluoromethyl)phenyl)ethane-1,2-dione;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(hydroxymethyl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3',4'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3',5'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2',5'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(oxetan-3-yl)ethyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(trifluoromethyl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(piperidin-1-ylmethyl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)nicotinonitrile;
(R)-2-(1-(3-(6-(dimethylamino)pyridin-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-dimethyl-[1,1'-biphenyl]-3-carboxamide;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-fluoro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-fluoro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(5'-fluoro-2'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2',3'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-chloro-3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-([1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2',4'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(5-bromopyridin-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(5-(3-(trifluoromethyl)phenyl)pyridin-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(5-(3-chlorophenyl)pyridin-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(4-(2-((3S,5S)-adamantan-1-yl)ethyl)thiophen-2-yl)cyclopropyl)-6-((RS)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(trifluoromethoxy)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-methoxypyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3'-((dimethylamino)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(5-(3-fluorophenyl)pyridin-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(2'-(trifluoromethyl)-[3,4'-bipyridin]-5-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(6-(3-fluorophenyl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-sulfonamide;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(4-hydroxytetrahydro-2H-pyran-4-yl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-pyrazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-(difluoromethyl)-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-pyrazol-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-cyclobutyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-dimethyl-[1,1'-biphenyl]-4-sulfonamide;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(oxazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(methylsulfonyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N-cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide;
(R)-N-benzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-isopropylthiophene-3-carboxamide;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(isoindoline-2-carbonyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4''-chloro-[1,1':4',1''-terphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(methylamino)pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4'-(dimethylamino)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(pyrrolidin-1-yl)pyrimidin-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)-3-methylbenzo[d]oxazol-2(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(piperidine-1-carbonyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3'-(2-methoxyethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(2-methoxyethoxy)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-methylpiperidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-((4-methylpiperazin-1-yl)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-methoxypyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(1-methylpiperidin-4-yl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-cyclopentylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(5-cyclopentylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(thiazol-5-yl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(pyridin-3-yl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-([3,3'-bipyridin]-5-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-(isothiazol-4-yl)pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(2-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(2-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-phenylacetyl)piperidin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-(3,3-dimethylbutanoyl)piperidin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-benzoylpiperidin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(3-phenylpropanoyl)piperidin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(pyridin-3-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(isothiazol-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(2',3',4',5'-tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(prop-1-en-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-(tetrahydro-2H-pyran-4-yl)pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-(tetrahydro-2H-pyran-4-yl)pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(tetrahydro-2H-pyran-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-([3,3'-bipyridin]-5-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-(isothiazol-4-yl)pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(methylamino)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(pyrrolidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(pyrrolidin-1-ylmethyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(tetrahydro-2H-pyran-4-yl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(pyridin-3-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(tetrahydro-2H-pyran-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(tetrahydro-2H-pyran-4-yl)thiophene-3-carboxamide;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-isopropyl-N-methylthiophene-3-carboxamide;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(piperidine-1-carbonyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(1-hydroxycyclohexyl)ethyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-indazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-indazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-2-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-(4,4-difluorocyclohexyl)pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(5-(4,4-difluorocyclohexyl)pyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(tetrahydro-2H-pyran-4-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(4-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-phenoxypyridin-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(S)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(quinolin-6-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(isoquinolin-6-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(quinolin-7-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(quinolin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(benzofuran-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(4'-(pyridin-2-ylmethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(6-(benzyloxy)pyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)-N,N-dimethylnicotinamide;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(1-(trifluoromethyl)cyclopropane-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4'-chloro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(2-methoxypyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
8-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(tetrahydro-2H-pyran-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3'-chloro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3'-(2-methoxyethoxy)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-isobutyrylpiperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(6-(4-(3,3-dimethylbutanoyl)piperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-(2-phenylacetyl)piperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)picolinonitrile;
(R)-2-(1-(4'-((dimethylamino)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(pyridin-2-ylmethoxy)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-(benzyloxy)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4-(benzyloxy)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-([1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(1-methyl-1H-indazol-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(1-methyl-1H-indazol-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(S)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-([1,1'-biphenyl]-2-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-methyl-1H-indazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-methyl-1H-indazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-1-(3'-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carbonitrile;
(R)-3'-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-sulfonamide;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(4,4-difluorocyclohexyl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-(indolin-1-yl)acetyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-4-(((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)(methyl)amino)-4-oxobutanoic acid;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(2-phenoxypyridin-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(isothiazol-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-(isothiazol-4-yl)pyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-(isothiazol-4-yl)pyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(piperidine-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N-((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)-N-methylpiperidine-1-carboxamide;
(R)-6-(2-(3-(cyclopent-1-en-1-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(naphthalen-1-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(naphthalen-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3',4'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
8,8-difluoro-2-(1-phenylcyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-N,N-dibenzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide;
(R)-N-benzhydryl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(4-phenoxybenzyl)thiophene-3-carboxamide;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(naphthalen-1-ylmethyl)thiophene-3-carboxamide;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-diisopropylthiophene-3-carboxamide;
6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-((trans)-4-(trifluoromethyl)cyclohexane-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-(4-(phenoxymethyl)phenyl)acetyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methylindolin-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(3-(2-oxopyrrolidin-1-yl)propanoyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-(1-(2,2,2-trifluoroethyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-(benzylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-(cyclohexylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-((4-fluorophenyl)sulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(2',3'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-5-chloro-3'-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3',5'-di-tert-butyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzofuran-2-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-2-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzofuran-3-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3',4'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3',5'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(2,3-dihydrobenzofuran-5-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(1-(3-(trifluoromethyl)phenyl)cyclopropane-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-(3-(cyclopentyloxy)-4-methoxybenzoyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N-cyclohexyl-4-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)-3,6-dihydropyridine-1(2H)-carboxamide;
(R)-3-cyclohexyl-1-((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)-1-methylurea;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-phenylpiperidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(6-(4-(benzyloxy)piperidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-4-(2-(((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)(methyl)amino)-2-oxoethyl)benzoic acid;
(R)-4-(((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)(methyl)carbamoyl)bicyclo[2.2.2]octane-1-carboxylic acid;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-(2-(4-(phenoxymethyl)phenyl)acetyl)piperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(6-(benzyloxy)pyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzofuran-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-(trifluoromethyl)pyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-phenyloxazol-5-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N-cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-isopropylthiophene-3-carboxamide;
(R)-N-benzyl-N-cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide;
(R)-N,N-dicyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(naphthalen-2-ylmethyl)thiophene-3-carboxamide;
(R)-N-(tert-butyl)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide;
6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-phenylcyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-phenylcyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzyloxy)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzyloxy)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(S)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(S)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',4'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(2',3'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(2',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-chloro-3'-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',4'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',5'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(2'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-((trifluoromethyl)thio)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-8-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
(R)-8-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
(R)-8-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
(R)-8-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
(R)-2-(1-(4'-((5-chloro-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4'-((4-(benzyloxy)piperidin-1-yl)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-5-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[d]thiazol-6-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[d]thiazol-2-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-phenyloxazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(5-phenylthiazol-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-5-chloro-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)-1-hydroxy-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2,2-difluoro-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(2'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-2-carbonitrile;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-carbonitrile;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2'-methyl-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-methyl-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-methyl-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3',4'-difluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3',5'-difluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-4-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-3-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-carbonitrile;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3,4-dicarbonitrile;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(2',3',4',5'-tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-isopropylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3,5-dicarbonitrile;
(R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-([1,1'-biphenyl]-4-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)-1-hydroxy-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)-1-hydroxy-2-oxoethyl)-[1,1'-biphenyl]-4-carbonitrile;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-([1,1'-biphenyl]-4-yloxy)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-([1,1'-biphenyl]-3-carbonyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-([1,1'-biphenyl]-4-carbonyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-([1,1'-biphenyl]-3-yloxy)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(3-phenoxybenzoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(4-phenoxybenzoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
8-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
2-(1-phenylcyclopropyl)-8-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-isopropylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethoxy)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(naphthalen-2-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-cyclopropylphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(E)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(3-(3-(trifluoromethyl)phenyl)acryloyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(benzofuran-3-yl)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
5-chloro-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(naphthalen-1-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(3-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzyloxy)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)-2-oxoethyl)-[1,1'-biphenyl]-4-carbonitrile;
6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
3'-(2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)ethyl)-[1,1'-biphenyl]-4-carbonitrile;
6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-phenylcyclopropyl)-6-(2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-phenylcyclopropyl)-6-(2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzofuran-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
5-chloro-3'-(2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)-2-oxoethyl)-[1,1'-biphenyl]-4-carbonitrile;
6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(benzofuran-3-yl)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
5-chloro-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile;
6-(2-(2-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-(benzyloxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzyloxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenoxy)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; and
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(phenylethynyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
or a pharmaceutically acceptable salt thereof;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(2-methoxypyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-methyl-1H-indazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(prop-1-en-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(6-(4-(benzyloxy)piperidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-methoxypyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-5-chloro-3'-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)-1-hydroxy-2-oxoethyl)-[1,1'-biphenyl]-4-carbonitrile;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-chloro-3'-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-2-(1-(3-(4,4-difluorocyclohexyl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(2',3',4',5'-tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-1-(3'-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carbonitrile;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(trifluoromethyl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N-cyclohexyl-4-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)-3,6-dihydropyridine-1(2H)-carboxamide;
(R)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(4,4-dimethylcyclohexyl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3'-(2-methoxyethoxy)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(pyrrolidin-1-yl)pyrimidin-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(5-cyclopentylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(2-methoxyethoxy)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-methyl-1H-indazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzofuran-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(1-(3-(trifluoromethyl)phenyl)cyclopropane-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(prop-1-en-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-ethylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',4'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1,1,1-trifluoropropan-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-methoxypyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-phenylcyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(piperidine-1-carbonyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-cycloheptylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-methylpiperidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(pyridin-2-ylmethoxy)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-chloro-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)-1-hydroxy-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(trifluoromethoxy)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzofuran-3-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-(3-(cyclopentyloxy)-4-methoxybenzoyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(cyclopent-1-en-1-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4'-(dimethylamino)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzofuran-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(4,4-difluorocyclohexyl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-4-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isobutylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(3-phenylpropanoyl)piperidin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-cyclobutyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(6-(dimethylamino)pyridin-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-3-cyclohexyl-1-((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)-1-methylurea;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)picolinonitrile;
(R)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)-1-hydroxy-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(5-phenylthiazol-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzofuran-2-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzyloxy)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(6-(benzyloxy)pyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-((trans)-4-(trifluoromethyl)cyclohexane-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)-3-methylbenzo[d]oxazol-2(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(2'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-cyclopentylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
5-chloro-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(methylsulfonyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(trifluoromethyl)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[d]thiazol-2-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N-benzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-isopropylthiophene-3-carboxamide;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
5-chloro-3'-(2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-2-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-(benzylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-(4-(phenoxymethyl)phenyl)acetyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',5'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(isothiazol-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-(3,3-dimethylbutyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(2'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(pyrrolidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(tetrahydro-2H-pyran-4-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(piperidine-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-diisopropylthiophene-3-carboxamide;
(R)-2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(4-(2-((3S,5S)-adamantan-1-yl)ethyl)thiophen-2-yl)cyclopropyl)-6-((RS)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3,4-dicarbonitrile;
6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-((trifluoromethyl)thio)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(6-(3-(trifluoromethyl)phenyl)pyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-carbonitrile;
(R)-3-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-carbonitrile;
6-(2-(3-(benzyloxy)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-phenylpiperidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-(2-(4-(phenoxymethyl)phenyl)acetyl)piperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(tetrahydro-2H-pyran-4-yl)ethyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-dimethyl-[1,1'-biphenyl]-4-sulfonamide;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzyloxy)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',4'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-phenylcyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
8-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
6-(2-hydroxy-2-(6-(3-(trifluoromethoxy)phenyl)pyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4'-((4-(benzyloxy)piperidin-1-yl)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(naphthalen-1-ylmethyl)thiophene-3-carboxamide;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-([1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)nicotinonitrile;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-phenylacetyl)piperidin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-ethylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-methyl-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-(benzyloxy)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-indazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-(difluoromethyl)-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-benzoylpiperidin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(4-hydroxytetrahydro-2H-pyran-4-yl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4'-chloro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)-2-oxoethyl)-[1,1'-biphenyl]-4-carbonitrile;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(tetrahydro-2H-pyran-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-(2-cyclopropylethyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-indazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-(cyclohexylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(2',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2'-methyl-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(tetrahydro-2H-pyran-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(methylamino)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methylindolin-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4'-((5-chloro-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenethylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzyloxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(4-phenoxybenzyl)thiophene-3-carboxamide;
(R)-N-benzyl-N-cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3,5-dicarbonitrile;
(R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(1-hydroxycyclohexyl)ethyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-(benzo[d]thiazol-6-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-N-((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)-N-methylpiperidine-1-carboxamide;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N-benzhydryl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(naphthalen-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N-cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-isopropylthiophene-3-carboxamide;
(R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-(3,3-dimethylbutanoyl)piperidin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-((4-fluorophenyl)sulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3'-chloro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(2'-(trifluoromethyl)-[2,4'-bipyridin]-6-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N,N-dibenzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide;
2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-(6-(4-(3,3-dimethylbutanoyl)piperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(2-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-5-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(thiazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N,N-dicyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(benzofuran-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-isopropylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-2-carbonitrile;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(isothiazol-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-(indolin-1-yl)acetyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-N-cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-methyl-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(5-(3-(trifluoromethyl)phenyl)pyridin-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzofuran-3-yl)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(3-methoxypropyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N-benzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide;
(R)-6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(naphthalen-2-ylmethyl)thiophene-3-carboxamide;
6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-(trifluoromethyl)pyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(oxetan-3-yl)ethyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3',5'-difluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(1-(trifluoromethyl)cyclopropane-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-8-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
(R)-2-(1-(3',4'-difluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-8-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-isobutyrylpiperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-pyrazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-phenyloxazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-(benzyloxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(tetrahydro-2H-pyran-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-isopropylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-(1-(2,2,2-trifluoroethyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-(2-phenylacetyl)piperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(2',3'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',5'-di-tert-butyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-(benzo[b]thiophen-2-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-isopropylpyridin-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(oxazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-cyclopropylphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-8-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(2',3',4',5'-tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(6-(benzyloxy)pyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(E)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(3-(3-(trifluoromethyl)phenyl)acryloyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(5-(4,4-difluorocyclohexyl)pyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(5-(3-chlorophenyl)pyridin-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-dimethyl-[1,1'-biphenyl]-3-carboxamide;
6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-((trifluoromethyl)thio)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-(4,4-difluorocyclohexyl)pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one
6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(naphthalen-1-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(6-(3-cyclopropylphenyl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4''-chloro-[1,1':4',1''-terphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(naphthalen-1-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(methylamino)pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',4'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-8-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyrimidin-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-phenoxypyridin-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; and
6-(2-(2-fluoro-3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
or a pharmaceutically acceptable salt thereof;
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(m-tolyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-bromo-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-fluoro-3-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)ethyl)benzonitrile;
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; and
6-(2-hydroxy-2-(m-tolyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
or a pharmaceutically acceptable salt thereof;
R1 and R2 are independently selected from the group consisting of: hydrogen, hydroxyl, halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxyl, (C1-C6)haloalkoxy, (C3-C7)cycloalkyl, and phenyl(C0-C4)alkyl; wherein the said (C3-C7)cycloalkyl or phenyl(C0-C4)alkyl is optionally substituted with 1 to 4 substituents independently selected from the group consisting of: halogen, hydroxyl, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, and (C1-C6)haloalkoxy; or alternatively R1 and R2, together with the atom to which they are attached, may form a 3 to 8 membered ring which may contain 0 to 4 heteroatoms independently selected from oxygen, sulfur, and nitrogen; wherein the said 3 to 8 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, (C1-C6)alkyl, (C1-C6)haloalkyl, -SO2(C1-C6)alkyl, -SO2(C1-C6)haloalkyl, -C(=O)(C1-C6)alkyl, and -C(=O)(C1-C6)haloalkyl;
R3 is independently selected from the group consisting of: hydrogen, fluoride, methyl, ethyl, and (C1-C6)haloalkyl;
q is 1, 2, 3, or 4;
r is 1, 2, 3, or 4;
s is 1, 2, 3, or 4;
or a pharmaceutically acceptable salt thereof.
(R)-2-(1-(5-bromopyridin-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-bromophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(5-bromopyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-bromophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(2-bromopyridin-4-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(6-bromopyridin-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-bromophenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-bromophenyl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-bromophenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-bromophenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; and
2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
or a pharmaceutically acceptable salt thereof.
Examples of such heteroaryl include, but are not limited to, thiophenyl, thiazolyl, isoxazolyl, pyrazolyl, pyrazyl, tetrazolyl, furanyl, pyrrolyl, imidazolyl, oxazolyl, isothiazolyl, triazolyl, thiadiazolyl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, pyranyl, triazinyl, 3,6-dihydro-2H-pyran, 1,2,3,6-tetrahydropyridyl, benzofuranyl, benzothiophenyl, benzotriazolyl, benzoxazolyl, indolyl, indazolyl, benzoimidazolyl, pyrrolopyridyl, 2,3-dihydro-pyrrolo[2,3-b]pyridyl, 2,3-dihydro-1H-pyrrolo[2,3-c]pyridyl, pyrrolopyrimidinyl, pyrazolopyridyl, pyrazolopyrimidinyl, imidazopyridinyl, furopyridyl, benzoisoxazolyl, imidazopyrazinyl, imidazopyridazinyl, imidazopyrimidinyl, quinolyl, isoquinolyl, quinoxalyl, quinazolinyl, phthalazinyl, quinoxalinyl, naphthyridinyl, pyridopyrimidinyl, 2,3-dihydro-[1,4]dioxino[2,3-b]pyridyl, 2,3-dihydro-[1,4]dioxino[2,3-c]pyridyl, 1H-indolyl, 1H-pyrrolo[2,3-b]pyridyl, 1H-pyrrolo[2,3-c]pyridyl, 1H-pyrrolo[3,2-c]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 7H-pyrrolo[2,3-d]pyrimidyl, 7H-pyrrolo[2,3-c]pyridazinyl, 1H-indazolyl, 2H-indazolyl, 1H-pyrazolo[3,4-b]pyridyl, 1H-pyrazolo[3,4-c]pyridyl, 1H-pyrazolo[4,3-c]pyridyl, 1H-pyrazolo[4,3-b]pyridyl, 1H-pyrazolo[3,4-d]pyrimidyl, 1H-benzo[d]imidazolyl, 3H-imidazo[4,5-b]pyridyl, 1H-imidazo[4,5-b]pyridyl, 9H-purinyl, 1H-imidazo[4,5-d]pyridazinyl, 1H-imidazo[4,5-b]pyrazinyl, imidazo[1,2-a]pyridyl, imidazo[1,5-a]pyridyl, imidazo[1,2-a]pyrazinyl, imidazo[1,2-b]pyridazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidyl, furo[3,2-c]pyridyl, benzo[d]isoxazolyl, 2,3-dihydro-1H-indenyl, indolinyl, isoindolinyl, indolin-2-one-yl, isoindolin-1-one-yl, 1H-benzo[d]imidazol-2(3H)-one-yl, benzo[d]oxazol-2(3H)-one-yl, 1H-pyrrolo[2,3-b]pyridin-2(3H)-one-yl, 1H-imidazo[4,5-b]pyridin-2(3H)-one-yl, quinolyl, isoquinolyl, quinazolinyl, phthalazinyl, 2,6-naphthyridinyl, 2,7-naphthyridinyl, quinoxalinyl, pyrido[3,4-d]pyrimidyl, pyrido[2,3-d]pyrimidyl, 1,2,3,4-tetrahydroquinolyl, 1,2,3,4-tetrahydroisoquinolyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 2,3-dihydro-[1,4]dioxino[2,3-b]pyridyl, 3,4-dihydroquinolin-2(1H)-one-yl, 2H-benzo[b][1,4]oxazin-3(4H)-one-yl, quinolin-2(1H)-one-yl, benzo[d][1,3]dioxolyl, or 4,5-dihydro-1H-benzo[b]azepin-2(3H)-one-yl, and N-oxides thereof and S-oxides thereof and the like.
Preferable heteroaryl is 5 to 6-membered heteroaromatic ring with 1-4 heteroatoms independently selected from O, N, and S, or 9 to 10-membered heteroaromatic ring with 1-4 heteroatoms independently selected from O, N, and S, more preferable heteroaryl is 5 to 6-membered N-containing heteroaromatic ring, further more preferable heteroaryl is benzoimidazolyl, dihydroisoquinolyl, indolyl, indazolyl, pyrazolyl, pyrazinyl, pyridazinyl, pyridyl, quinolyl, isoquinolyl and thiazolyl.
Throughout the instant application, the following abbreviations are used with the following meanings:
DMF: N,N-Dimethylformamide
THF: Tetrahydrofuran
DMSO: Dimethylsulfoxide
NMP: N-methylpyrrolidone
EtOAc: Ethyl acetate
Me: Methyl
MeOH: Methanol
EtOH: Ethanol
BuOH: Butanol
DCM: Dichloromethane
DIPEA: N,N-Diisopropylethylamine
DME: 1,2-dimethoxyethane
TFA: Trifluoroacetic acid
MeCN: Acetonitrile
Et3N: Triethylamine
DMAP: 4-Dimethylaminopyridine
EDC: 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride
HOBT: 1-Hydroxybenzotriazole
HBTU: O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Hexafluorophosphate
HATU: O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Hexafluorophosphate
BOP: (Benzotriazol-1-yloxy)tris(dimethylamino) phosphonium Hexafluorophosphate
T3P: Propylphosphonic Acid Anhydride (Cyclic Trimer)
Pd(dba)3: Tris(dibenzylideneacetone)dipalladium(0)
Pd(Amphos)Cl2: Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II)
PdCl2(dppf)・DCM:
[1, 1’-Bis(diphenylphosphino)ferrocene]dichloropalladium (II), Dichloromethane Adduct
Pd(PPh3)4 : Tetrakis(triphenylphosphine)palladium (0)
XantPhos Pd G3: [2'-(Amino-κN)[1,1'-biphenyl]-2-yl-κC][[5-(diphenylphosphino)-9,9-dimethyl-9H-xanthen-4-yl]diphenylphosphine-κP](methanesulfonato-κO)palladium
SCX: Strong Cation Exchanger
SFC: Supercritical fluid chromatography
Zn(CN)2: Zinc cyanide
HPLC: High performance liquid chromatography
tR: Retention time
MHz: Megahertz
NMR: Nuclear Magnetic Resonance
TLC: Thin layer chromatography
rt: room temperature
ee: enantio excess, enantiomeric excess or enantiomer excess
eq.: quantitative
obs: observed
mp: melting point
The invention is illustrated in the following non-limiting examples in which, unless stated otherwise: all reagents are commercially available, all operations are carried out at room or ambient temperature, that is, in the range of about 18 to 25 oC; evaporation of solvent is carried out using a rotary evaporator under reduced pressure with a bath temperature of up to about 60 oC; reactions are monitored by thin layer chromatography (TLC)(Merck silica gel 60 F254 precoated TLC plates or Merck NH2 F254 precoated HPTLC plates) or LC-MS and reaction times are given for illustration only; the structure and purity of all isolated compounds are assured by at least one of the following techniques: LC-MS and nuclear magnetic resonance (NMR). Microwave reaction is conducted by Initiator+ (registered trademark)(Biotage). Yields are given for illustrative purposes only. The column chromatography system is conducted by Yamazen and Biotage (Isolera one). Flash column chromatography is carried out using Merck silica gel 60 (230-400 mesh ASTM), Fuji Silysia Chromatorex (registered trademark) NH-DH1020, Biotage silica (32-63 mm, KP-Sil), Biotage amino bounded silica (35-75 mm, KP-NH), Wakogel (registered trademark) C-300HGT, Hi-Flash (registered trademark) column (YAMAZEN, silica gel, 40 micro meters, 60 angstrom), Hi-Flash (registered trademark) column (YAMAZEN, amino, 40 micro meters, 60 angstrom).
Apparatus: Waters MS-trigger AutoPurification (registered trademark) system
Column: Waters XBridge C8, 19 mm x 50 mm, 5 micrometer particle or Waters XBridge C18, 19 mm x 50 mm, 5 micrometer particle
Mobile phase 1: (A) 0.05%(v/v) ammonia aqueous solution, (B) MeOH or MeCN
Mobile phase 2: (A) 0.05%(v/v) formic acid aqueous solution, (B) MeOH or MeCN
Mobile phase 3: (A) 10 mM ammonium formate aqueous solution, (B) MeCN/water = 90/10(v/v)
Flow rate: 20 mL/min
Gradient: A/B (95/5) to A/B (5/95) in 5 or 7 or 10 min
Apparatus: Waters Prep15 SFC system with ACQUITY QDa Detector
Column: Waters Torus 2-PIC, 10 mm x 150 mm, 5 micrometer particle; Waters Torus DEA, 10 mm x 150 mm, 5 micrometer particle; Waters Torus DIOL, 10 mm x 150 mm, 5 micrometer particle; Waters Torus 1-AA, 10 mm x 150 mm, 5 micrometer particle
Mobile phase: (A) Carbon dioxide (CO2), (B) MeOH or 10 mM ammonia in MeOH
Flow rate: 15 mL/min
Gradient: A/B (95/5) to A/B (60/40) in 7 or 10 min
Temperature: 40 oC
Pressure: 120 bar (1740 psi)
Apparatus: Waters Acquity Ultra Performance LC with PDA Detector and ZQ mass spectrometer
Column: YMC Triart C18, 2.1 x 100 mm, 1.9 micrometer particle
Column Temperature: 60 oC
PDA detection: 200 - 400 nm scan
MS detection: ESI positive/negative mode
Mobile phase:
QC-A1 (neutral method)
A: 10 mM ammonium acetate aqueous solution
B: acetonitrile
QC-A2 (basic method)
A: 0.05%(v/v) ammonia aqueous solution
B: acetonitrile
Apparatus: Waters ACQUITY UPLC H-Class PLUS with PDA Detector and SQ Detector 2 mass spectrometer
Column: YMC Triart C18, 2.1 x 100 mm, 1.9 micrometer particle
Column Temperature: 60 oC
PDA detection: 200 - 400 nm scan
MS detection: ESI positive/negative mode
Mobile phase:
QC-B1 (neutral method)
A: 10 mM ammonium acetate aqueous solution
B: acetonitrile
QC-B2 (basic method)
A: 0.05%(v/v) ammonia aqueous solution
B: acetonitrile
Apparatus: Waters 2795 Alliance HPLC with 2996 PDA Detector and ZQ 2000 mass spectrometer
Column: Waters Xbridge C18, 2.1 x 50 mm, 3.5 micrometer particle
Column Temperature: 45 oC
PDA detection: 210 - 400 nm scan
MS detection: ESI positive/negative mode
Mobile phase:
QC-C (neutral method)
A: H2O (Milli-Q water)
B: acetonitrile
C: 1% aqueous HCO2H
D: 1% aqueous NH3
Apparatus: Waters Acquity Ultra Performance LC on TUV Detector and ZQ mass spectrometer
Column: Waters ACQUITY C18, 2.1 x 100 mm, 1.7 micrometer particle
Column Temperature: 60 oC
PDA detection: 210 nm scan
MS detection: ESI positive/negative mode
In this Scheme-3, a corresponding amine derivative of formula (II) can be prepared by the cyclization reaction of an N-protected compound of formula (VI) with an amidine compound of formula (IV) in the presence of base in an inert solvent, followed by the deprotection of an N-protected compound of formula (VII).
1) Starting Material (1.0 eq.), boronic acid derivative (1.0 to 3.0 eq.), palladium (II) acetate (0.2 eq.), triphenylphosphine (0.4 eq.), 1,4-dioxane-saturated sodium hydrogen carbonate aqueous solution (1:1 v/v), 100-150 oC, 1-6 hrs or Microwave (100-150 oC, 10 min. to 1 hr)
2) Starting Material (1.0 eq.), boronic acid derivative (1.0 to 3.0 eq.), Pd(amphos)Cl2 (0.1 to 0.5 eq.), potassium carbonate (2.0 to 4.0 eq.), 1,4-dioxane-water (1:1 to 3:1 v/v), 80-150 oC, 1-6 hrs or Microwave (100-150 oC, 10 min. to 1 hr)
3) Starting Material (1.0 eq.), boronic acid derivative (1.0 to 3.0 eq.), Pd(PPh3)4 (0.1 to 0.5 eq.), potassium carbonate (2.0 to 4.0 eq.), DMF, 80-150 oC, 1-6 hrs or Microwave (100-150 oC, 10 min. to 1 hr)
The cyano derivatives of formula (I-b) are synthesized by using zinc cyanide in place of compounds of formula (XI) under the above cross coupling conditions.
The synthesis of the compounds of the general formulae (I) and (I-a) and pharmaceutically acceptable derivatives and salts thereof may be accomplished as outline above in Schemes 1 to 13. In the following description, the groups are as defined above for compounds of formulae (I) and (I-a) unless otherwise indicated. Starting materials are commercially available or are made from commercially available starting materials using methods known to those skilled in the art. The naming program used is ChemDraw Ver. 18.2.
2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (INT-1)
Synthesis of tert-butyl 4-oxo-2-(1-(3-(prop-1-en-2-yl)phenyl)cyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-6(4H)-carboxylate (INT-6-1)
Synthesis of tert-butyl 2-(1-(3-isopropylphenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-6(4H)-carboxylate (INT-7-1)
Synthesis of 4-(1-(4-oxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-2-yl)cyclopropyl)benzonitrile (INT-9-1)
Synthesis of tert-butyl 4-oxo-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-6(4H)-carboxylate (INT-9-3)
Synthesis of tert-butyl 2-(1-(3-(benzo[b]thiophen-5-yl)phenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepine-6-carboxylate
Synthesis of (R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one
Synthesis of (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(cyclopent-1-en-1-yl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one
Synthesis of (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-(prop-1-en-2-yl)pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one
Synthesis of (R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(prop-1-en-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one (INT-18-1)
Synthesis of 2-(1-(4-(adamantan-1-ylethynyl)thiophen-2-yl)cyclopropyl)-6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-6,7,8,9-tetrahydro-3H-pyrimido[5,4-c]azepin-4(5H)-one (INT-20-1)
Syntehsis of (R)-2-(1-(3-(cyclopent-1-en-1-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one
Synthesis of (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(6-(prop-1-en-2-yl)pyridin-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one
Synthesis of (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-(prop-1-en-2-yl)pyridin-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one (INT-23-1)
Syntehsis of 2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetic acid (INT-25-1)
Synthesis of (R)-2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetic acid (INT-26-1)
Synthesis of (R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxylic acid (INT-27-1)
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxylic acid
Synthesis of (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridin-1(2H)-yl)(1-(trifluoromethyl)cyclopropyl)methanone
Synthesis of piperidin-1-yl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridin-1(2H)-yl)methanone (INT-29-1)
Synthesis of N-cyclohexyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridine-1(2H)-carboxamide (INT-30-1)
Synthesis of 1-((4-fluorophenyl)sulfonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine (INT-31-1)
Synthesis of 3,3-dimethyl-1-(4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazin-1-yl)butan-1-one (INT-32-1)
Synthesis of N-methyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperidine-1-carboxamide (INT-33-1)
Synthesis of 3-cyclohexyl-1-methyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)urea (INT-34-1)
Synthesis of ethyl 4-(methyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)amino)-4-oxobutanoate (INT-35-1)
Synthesis of 4-(benzyloxy)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperidine
Synthesis of (6-(4-phenylpiperidin-1-yl)pyridin-3-yl)boronic acid (INT-37-1)
(R)-(-)-2-(2,3-difluorophenyl)-2-hydroxyacetic acid (INT-38-1) and (S)-(+)-2-(2,3-difluorophenyl)-2-hydroxyacetic acid (INT-38-2)
(R)-(-)-2-(3-bromophenyl)-2-hydroxyacetic acid (INT-39-1) and (S)-(+)-2-(3-bromophenyl)-2-hydroxyacetic acid (INT-39-2)
(R)-(-)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetic acid (INT-40-1) and (S)-(+)-2-(3-bromophenyl)-2-hydroxyacetic acid (INT-40-2)
Chiral 2-(3,5-difluorophenyl)-2-hydroxyacetic acid (INT-41-1 and INT-41-2)
88%e.e. (Method-L)
>99%e.e. (Method-L)
Chiral 2-(3-chloro-2-fluorophenyl)-2-hydroxyacetic acid (INT-43-1 and INT-43-2)
(R)-2-(1-phenylcyclopropyl)-6-(2-phenylpropanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-1)
(E)-6-(3-(3-chlorophenyl)acryloyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-2-29)
6-((1S*,2S*)-2-phenylcyclopropanecarbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-2-30)
6-((1S*,2S*)-2-(2,5-difluorophenyl)cyclopropanecarbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-2-31)
(R)-6-(2-hydroxy-2-phenylacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-2-32)
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-2-33)
(R)-(-)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-2-34)
(S)-(+)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-2-35)
(R)-(-)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-2-36)
(S)-(+)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-2-37)
(R)-(-)-2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-2-38)
(R)-(-)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-2-39)
(Chiral)-6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-2-40)
(Chiral)-6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-2-41)
(-)-2-(1-(4-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(m-tolyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-2-42)
(-)-2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(m-tolyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-2-43)
6-(2-hydroxy-2-(m-tolyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-4-1)
6-(2-hydroxy-2-(3-(6-methylpyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-4-3)
3-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(5H)-yl)ethyl)benzonitrile (Ex-4-5)
Chiral 6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-4-14 and Ex-4-15)
(R)-(-)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-5-1)
(+)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-5-2)
6-((R)-2-(3-chlorophenyl)-2-hydroxyacetyl)-2-((R/S)-1-phenylethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-7-1)
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-8-1)
6-(2-hydroxy-2-(2-(pyrrolidin-1-yl)pyridin-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-11-1)
4-oxo-2-(1-phenylcyclopropyl)-N-(3-(trifluoromethyl)phenyl)-3,4,7,8-tetrahydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide (Ex-12-1)
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-23-1)
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one (Ex-29-2)
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(thiazol-5-yl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-33-1)
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (Ex-44-1)
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-diisopropylthiophene-3-carboxamide (Ex-59-14)
(R)-2-(1-(3-acetylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one (Ex-60-1)
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(hydroxymethyl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one (Ex-61-1)
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(piperidin-1-ylmethyl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one (Ex-62-1)
Synthesis of (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(piperidin-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one (Ex-63-1)
Synthesis of (R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(1-methylpiperidin-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one (Ex-64-1)
TRPV4 channel activation/opening results in an influx of Ca2+ (Liedtke, W. et al., 2000 (NPL 1)). The resulting changes in intracellular calcium are monitored using a Ca2+ sensitive fluorescent dye Fluo-4 (Invitrogen). Dye loaded cells are treated with the test compounds for 5 minutes prior to the addition of a hypotonic solution and the inhibition of the hypotonicity-induced activation is recorded.
Forty microL of tetracycline-inducible Flp-In T-REx 293 cells (Invitrogen) stably expressing human TRPV4 are seeded onto the poly-D-lysine coated 384-well plate (Corning) at a density of 10,000 cells per well. The following day, TRPV4 expression is induced by adding 0.5 microg/mL tetracycline for 20-24 hours. On the day of the experiment, the media is removed and replaced with 40 microL of dye loading buffer [1 microM Fluo-4 AM (Invitrogen), 0.01% Pluronic F-127, and 20 mM HEPES in Hanks' balanced salt solutions (HBSS; Invitrogen)] and then the cells are incubated for 60 minutes at 25oC. Dye is then removed and replaced with 20 microL of assay buffer (20 mM HEPES in HBSS). Five minutes prior to the fluorescence measurement, 10 microL of test compound is added to the cells. Using the FDSS instrument (Hamamatsu Photonics), 30 microL of hypotonic solution (90 mM D-mannitol and 1.26 mM CaCl2 in ultrapure water) is added 30 seconds after the start of measurement. The calcium flux signal is recorded for a total of 4.5 minutes.
Human HERG transfected HEK293S cells are prepared and grown in-house. The collected cells are suspended in 50 mM Tris-HCl (pH 7.4 at 4 oC) and homogenized using a hand held Polytron PT 1200 disruptor set at full power for 20 sec on ice. The homogenates are centrifuged at 48,000 x g at 4 oC for 20 min. The pellets are then resuspended, homogenized, and centrifuged once more in the same manner. The final pellets are resuspended in an appropriate volume of 50 mM Tris-HCl, 10 mM KCl, 1 mM MgCl2 (pH 7.4 at 4 oC), homogenized, aliquoted and stored at -80 oC until use. An aliquot of membrane fractions is used for protein concentration determination using BCA protein assay kit (PIERCE) and ARVOsx plate reader (Wallac). Binding assays are conducted in a total volume of 30 microL in 384-well plates. The activity is measured by PHERAstar (BMG LABTECH) using fluorescence polarization technology. Ten microL of test compounds are incubated with 10 microL of fluorescence ligand (6 nM Cy3B tagged dofetilide derivative) and 10 microL of membrane homogenate (6 microg protein) for 120 minutes at room temperature. Nonspecific binding is determined by 10 microM E4031 at the final concentration.
Half-life in human liver microsomes (HLM)
Test compounds (1 microM) are incubated with 3.3 mM MgCl2 and 0.78 mg/mL HLM (HL101) or 0.74 mg/mL HLM (Gentest UltraPool 150) in 100 mM potassium phosphate buffer (pH 7.4) at 37 oC on the 96-deep well plate. The reaction mixture is split into two groups, a non-P450 group and a P450 group. NADPH is only added to the reaction mixture of the P450 group. (NADPH generation system is also used instead of NADPH.) An aliquot of samples of P450 group is collected at 0, 10, 30, and 60 min time point, where 0 min time point indicated the time when NADPH is added into the reaction mixture of P450 group. An aliquot of samples of non-P450 group is collected at -10 and 65 min time point. Collected aliquots are extracted with acetonitrile solution containing an internal standard. The precipitated protein is spun down in centrifuge (2000 rpm, 15 min). The compound concentration in supernatant is measured by LC/MS/MS system.
This method essentially involves determining the percent inhibition of metabolites formation from probes (Tacrine (Sigma A3773-1G) 2 microM, Dextromethorphan (Sigma D-9684) 5 microM, Diclofenac (Sigma D-6899-10G) 5 microM, and Midazolam (ULTRAFINE UC-429) 2 microM) at 3 microM of the each compound.
The metabolites' concentration in the supernatant is measured by LC/MS/MS system.
The degree of drug-drug interaction is interpreted based on generation % of metabolites in the presence or absence of test compound.
The compounds of this invention show preferable results, which shows the above-mentioned practical use.
Plasma protein binding of the test compound (1 microM) is measured by the method of equilibrium dialysis using 96-well plate type equipment. HTD96a (registered trademark), regenerated cellulose membranes (molecular weight cut-off 12,000-14,000, 22 mm x 120 mm) are soaked for overnight in distilled water, then for 15 minutes in 30% ethanol, and finally for 20 minutes in dialysis buffer (Dulbecco's phosphate buffered saline, pH 7.4). Frozen plasma of human, Sprague-Dawley rats, and Beagle dogs are used. The dialysis equipment is assembled and added 150 microL of compound-fortified plasma to one side of each well and 150 microL of dialysis buffer to the other side of each well. After 4 hours incubation at 37 oC for 150 rpm, aliquots of plasma and buffer are sampled. The compound in plasma and buffer are extracted with 300 microL of acetonitrile containing internal standard compounds for analysis. The concentration of the compound is determined with LC/MS/MS analysis.
The fraction of the compound unbound is calculated by the following equation (A) or (B):
Cis,p is the peak area of the internal standard in plasma sample;
Cb is the peak area of the compound in buffer sample;
Cis,b is the peak area of the internal standard in buffer sample;
4 and 4/3 is the reciprocal of the dilution rate in plasma and buffer, respectively.
Claims (20)
- A compound of the following formula (I):
R1 and R2 are independently selected from the group consisting of: hydrogen, hydroxyl, halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxyl, (C1-C6)haloalkoxy, (C3-C7)cycloalkyl, and phenyl(C0-C4)alkyl; wherein the said (C3-C7)cycloalkyl or phenyl(C0-C4)alkyl is optionally substituted with 1 to 4 substituents independently selected from the group consisting of: halogen, hydroxyl, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, and (C1-C6)haloalkoxy; or alternatively R1 and R2, together with the atom to which they are attached, may form a 3 to 8 membered ring which may contain 0 to 4 heteroatoms independently selected from oxygen, sulfur, and nitrogen; wherein the said 3 to 8 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, (C1-C6)alkyl, (C1-C6)haloalkyl, -SO2(C1-C6)alkyl, -SO2(C1-C6)haloalkyl, -C(=O)(C1-C6)alkyl, and -C(=O)(C1-C6)haloalkyl;
R3 is independently selected from the group consisting of: hydrogen, fluoride, methyl, ethyl, and (C1-C6)haloalkyl;
X is selected from the group consisting of: a chemical bond, -N(R4)-, -(C(R5)(R6))n-, -(C3-C8)cycloalkyl-, -C(R5)=C(R6)-, -C(=O)-, -CR4(N(R5)(R6))-, -[(C(R5)(R6))nO]-, -[(C(R5)(R6))nN(R4)]-, -[(C(R5)(R6))nS]-, and -[N(R4)(C(R5)(R6))n]-;
R4 is hydrogen or (C1-C6) alkyl;
R5 and R6 are independently selected from the group consisting of: hydrogen, halogen, hydroxyl, (C1-C6)alkyl, (C1-C6)alkoxy, hydroxyl(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)haloalkyl, and (C1-C6)haloalkoxy;
when R5 is two or more than two, R5 is same or different;
when R6 is two or more than two, R6 is same or different;
n is 1, 2, 3, or 4;
q is 1, 2, 3, or 4;
r is 1, 2, 3, or 4;
s is 1, 2, 3, or 4;
Ar1 is selected from aryl and heteroaryl which are optionally substituted with 1 to 6 substituents independently selected from the group consisting of: hydrogen, halogen, cyano, nitro, hydroxyl, -C(=O)R7, -C(=O)NR7R8, -NHSO2R7, -SO2NR7R8, (C1-C6)alkylthio-, (C1-C6)haloalkylthio-, (C1-C6)alkylsulfinyl, (C1-C6)alkylsulfonyl, -NR7R8, tri(C1-C6)alkylsilyl, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C1-C6)alkoxy, (C1-C6)alkenyl, aryl(C0-C4)alkyl, heteroaryl(C0-C4)alkyl, aryl(C0-C6)alkoxy, heterocyclyl(C0-C4)alkyl, heterocyclyl(C0-C6)alkoxy, heteroaryl(C0-C6)alkoxy, and substituent group Q;
wherein the said (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C1-C6)alkoxy, (C1-C6)alkenyl, aryl(C0-C4)alkyl, heteroaryl(C0-C4)alkyl, aryl(C0-C6)alkoxy, heterocyclyl(C0-C4)alkyl, heterocyclyl(C0-C6)alkoxy, or heteroaryl(C0-C6)alkoxy is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, cyano, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkoxy, (C1-C6)haloalkoxy, phenyl, -NRaRb, RaRbN(C1-C6)alkyl, RaRbN(C1-C6)alkoxy, -C(=O)NRaRb, -C(=O)Ra, -SO2(C1-C6)alkyl, -SO2NRaRb, and RaRbNC(=O)(C1-C6)alkoxy; wherein the said (C3-C7)cycloalkyl is optionally substituted with hydroxyl or cyano; wherein the substituent group Q is
R7 and R8 are independently selected from the group consisting of: hydrogen, hydroxyl, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C1-C6)haloalkoxyl, (C3-C7)cycloalkyl, heterocyclyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)haloalkoxy(C1-C6)alkyl, benzyl, H2N(C1-C6)alkyl, (C1-C6)alkylNH(C1-C6)alkyl, and [(C1-C6)alkyl]2N(C1-C6)alkyl; or R7 and R8, together with nitrogen atom to which they are attached, may form a 3 to 10 membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen; wherein the said 3 to 10 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, oxo, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, -SO2(C1-C6)alkyl, -SO2(C1-C6)haloalkyl, -C(=O)(C1-C6)alkyl, and -C(=O) (C1-C6)haloalkyl;
Ra and Rb are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, (C3-C7)cycloalkyl, phenyl(C0-C6)alkyl, (C1-C6)haloalkoxy(C1-C6)alkyl, H2N(C1-C6)alkyl, (C1-C6)alkylNH(C1-C6)alkyl, and [(C1-C6)alkyl]2N(C1-C6)alkyl; or Ra and Rb, together with nitrogen atom to which they are attached, may form a 3 to 7 membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen; wherein the said 3 to 7 membered ring is optionally substituted with 1 to 3 substituents independently selected from (C1-C6)alkyl;
Ar2 is selected from aryl and heteroaryl which are optionally substituted with 1 to 6 substituents independently selected from the group consisting of: hydrogen, halogen, cyano, nitro, hydroxyl, -COR9, -CONR9R10, -NHSO2R9, -SO2NR9R10, (C1-C6)alkylthio-, (C1-C6)alkylsulfinyl, (C1-C6)alkylsulfonyl, -NR9R10, tri(C1-C6)alkylsilyl, (C1-C6)haloalkylthio-, -SF5, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C1-C6)alkoxy, aryl(C0-C4)alkyl, heteroaryl(C0-C4)alkyl, aryl(C0-C6)alkoxy, phenoxy, heteroaryl(C0-C6)alkoxy, heterocyclyl(C0-C4)alkyl, and heterocyclyl(C0-C6)alkoxy; wherein the said (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C1-C6)alkoxy, aryl(C0-C4)alkyl, heteroaryl(C0-C4)alkyl, aryl(C0-C6)alkoxy, phenoxy, heteroaryl(C0-C6)alkoxy, heterocyclyl(C0-C4)alkyl, or heterocyclyl(C0-C6)alkoxy is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, (C1-C6)alkyl, (C3-C7)cycloalkyl (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C6)alkoxy(C1-C6)alkoxy, (C1-C6)haloalkoxy, -NRcRd, RcRdN(C1-C6)alkyl, RcRdN(C1-C6)alkoxy, -C(=O)NRcRd, RcRdNC(=O)(C1-C6)alkoxy, benzyloxy, and cyano;
R9 and R10 are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)haloalkoxy(C1-C6)alkyl, H2N(C1-C6)alkyl, (C1-C6)alkylNH(C1-C6)alkyl, and [(C1-C6)alkyl]2N(C1-C6)alkyl; or R9 and R10, together with nitrogen atom to which they are attached, may form a 3 to 10 membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen; wherein the said 3 to 10 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, oxo, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, -SO2(C1-C6)alkyl, -SO2(C1-C6)haloalkyl, -C(=O)(C1-C6)alkyl, and -C(=O)(C1-C6)haloalkyl; and
Rc and Rd are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)haloalkoxy(C1-C6)alkyl, H2N(C1-C6)alkyl, (C1-C6)alkylNH(C1-C6)alkyl, and [(C1-C6)alkyl]2N(C1-C6)alkyl; or Rc and Rd, together with nitrogen atom to which they are attached, may form a 3 to 7 membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen;
or a pharmaceutically acceptable salt thereof. - The compound of the formula (I), according to claim 1, wherein
R1 and R2 are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxyl, (C1-C6)haloalkoxy, and (C3-C7)cycloalkyl; or alternatively R1 and R2, together with the atom to which they are attached, may form a 3 to 8 membered carbon ring;
X is selected from the group consisting of: a chemical bond, -(C(R5)(R6)-(CH2)m)-, -(C3-C8)cycloalkyl-, -CH=CH-, and -CH2O-;
m is 0, 1, 2, or 3; and
R5 and R6 are independently selected from the group consisting of: hydrogen, halogen, hydroxyl, and (C1-C6)alkyl;
or a pharmaceutically acceptable salt thereof. - The compound of the formula (I), according to claim 1 or claim 2, wherein
R1 and R2 are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxyl, (C1-C6)haloalkoxy, and (C3-C7)cycloalkyl; or alternatively R1 and R2, together with the atom to which they are attached, may form a 3 to 8 membered carbon ring;
X is selected from the group consisting of: a chemical bond and -CR5R6-;
R5 and R6 are independently selected from the group consisting of: hydrogen, halogen, hydroxyl, (C1-C6)alkyl, and (C1-C6)alkoxy;
q is 1, 2, or 3;
r is 1, 2, or 3;
s is 1, 2, or 3;
Ar1 is selected from aryl and heteroaryl which are optionally substituted with 1 to 6 substituents independently selected from the group consisting of: hydrogen, halogen, hydroxyl, cyano, -C(=O)R7, -C(=O)NR7R8, -NR7R8, -NHSO2R7, -SO2NR7R8, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkoxy, phenyl, heteroaryl, phenoxy, and heterocyclyl; wherein the said (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkoxy, phenyl, heteroaryl, phenoxy, or heterocyclyl is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, cyano, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, -NRaRb, -C(=O)NRaRb, and -C(=O)Ra;
R7 and R8 are independently selected from the group consisting of: hydrogen, hydroxyl, (C1-C6)alkyl, (C1-C6)haloalkyl, and (C3-C7)cycloalkyl; or R7 and R8, together with nitrogen atom to which they are attached, may form a 3 to 7 membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen; wherein the said 3 to 7 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, (C1-C6)alkyl, (C1-C6)alkoxy, and (C1-C6)haloalkyl;
Ra and Rb are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, and (C3-C7)cycloalkyl; or Ra and Rb, together with nitrogen atom to which they are attached, may form a 3 to 7 membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen; wherein the said 3 to 7 membered ring is optionally substituted with 1 to 3 substituents independently selected from methyl and ethyl;
Ar2 is selected from aryl and heteroaryl which are optionally substituted with 1 to 6 substituents independently selected from the group consisting of: hydrogen, halogen, hydroxyl, cyano, -COR9, -CONR9R10, -NHSO2R9, -SO2NR9R10, -NR9R10, (C1-C6)haloalkylthio-, -SF5, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C1-C6)alkoxy, phenyl, heteroaryl, phenoxy, and heterocyclyl; wherein the said (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C1-C6)alkoxy, phenyl, heteroaryl, phenoxy, or heterocyclyl is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, (C1-C6)alkyl, (C3-C7)cycloalkyl (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C6)haloalkoxy, -NRcRd, and -C(=O)NRcRd;
Rc and Rd are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, and hydroxy(C1-C6)alkyl; or Rc and Rd, together with nitrogen atom to which they are attached, may form a 3 to 7 membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen;
or a pharmaceutically acceptable salt thereof. - The compound of the formula (I), according to one of the claim 1 to 3, wherein;
R1 and R2 are independently selected from the group consisting of: hydrogen, methyl, and ethyl; or alternatively R1 and R2, together with the atom to which they are attached, may form a 3 to 6 membered carbon ring;
Ar1 is selected from aryl and heteroaryl which are optionally substituted with 1 to 6 substituents independently selected from the group consisting of: hydrogen, halogen, hydroxyl, cyano, -C(=O)R7, -C(=O)NR7R8, -NR7R8, -NHSO2R7, -SO2NR7R8, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkoxy, phenyl, naphthyl, phenoxy, pyridiyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, furanyl, benzofuranyl, thiophenyl, benzothiophenyl, imidazolyl, benzimidazole, indole, pyrazolyl, oxazolyl, isooxazolyl, thiazolyl, isothiazolyl, phenoxy, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, azetidinyl, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, and aziridinyl; wherein the said (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkoxy, phenyl, naphetyl, phenoxy, pyridiyl, pyrimidinyl, pyridazinyl, pyrazinyl, imidazolyl, pyrazolyl, furanyl, benzofuranyl, thiophenyl, benzothiophenyl, imidazolyl, benzimidazole, indole, pyrazolyl, oxazolyl, isooxazolyl, thiazolyl, isothiazolyl, phenoxy, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, azetidinyl, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, and aziridinyl; is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, cyano, (C1-C6)alkyl, and (C1-C6)haloalkyl;
wherein the said aryl is phenyl or naphthyl;
wherein the said heteroaryl is pyridiyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, furanyl, thiophenyl, imidazolyl, pyrazolyl, oxazolyl, isooxazolyl, thiazolyl, isothiazolyl, indolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, imidazonyridinyl, indazolyl, oxadiazolyl, benzoisoxazolyl, quinazolinyl, quinoxalinyl, quinolinyl, or isoquinolinyl;
R7 and R8 are independently selected from the group consisting of: hydrogen, hydroxyl, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C1-C6)haloalkoxyl, and (C3-C7)cycloalkyl;
Ar2 is selected from aryl and heteroaryl which are optionally substituted with 1 to 6 substituents independently selected from the group consisting of: hydrogen, halogen, hydroxyl, cyano, -SCF3, SF5, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C6)haloalkoxy, phenyl, naphthyl, phenoxy, pyridyl, oxazolyl, pyridazinyl, pyrazinyl, pyrrolyl, benzothiophenyl, furanyl, benzofuranyl, quinolinyl, isoquinolinyl, thiophenyl, pyrimidinyl, pyrazolyl, imidazolyl, benzimidazole, and indole; wherein the said phenyl, naphthyl, phenoxy, pyridyl, oxazolyl, pyridazinyl, pyrazinyl, pyrrolyl, benzothiophenyl, furanyl, benzofuranyl, quinolinyl, isoquinolinyl, thiophenyl, pyrimidinyl, pyrazolyl, imidazolyl, benzimidazole, or indole is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: hydrogen, halogen, hydroxyl, cyano, -SCF3, SF5, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, and (C1-C6)haloalkoxy;
wherein the said aryl is phenyl or naphthyl;
wherein the said heteroaryl is pyridiyl, pyrimidinyl, pyridazinyl, pyrazinyl, pyrrolyl, furanyl, thiophenyl, imidazolyl, pyrazolyl, oxazolyl, isooxazolyl, thiazolyl, isothiazolyl, indolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, imidazonyridinyl, indazolyl, oxadiazolyl, benzoisoxazolyl, quinazolinyl, quinoxalinyl, quinolinyl or isoquinolinyl;
or a pharmaceutically acceptable salt thereof. - A compound of the following formula (I-a):
R1 and R2 are independently selected from the group consisting of: hydrogen, hydroxyl, halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxyl, (C1-C6)haloalkoxy, (C3-C7)cycloalkyl, and phenyl(C0-C4)alkyl; wherein the said (C3-C7)cycloalkyl or phenyl(C0-C4)alkyl is optionally substituted with 1 to 4 substituents independently selected from the group consisting of: halogen, hydroxyl, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, and (C1-C6)haloalkoxy; or alternatively R1 and R2, together with the atom to which they are attached, may form a 3 to 8 membered carbon ring; the said 3 to 8 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, (C1-C6)alkyl, (C1-C6)haloalkyl, -SO2(C1-C6)alkyl, -SO2(C1-C6)haloalkyl, -C(=O)(C1-C6)alkyl, and -C(=O)(C1-C6)haloalkyl;
R3 is independently selected from the group consisting of: hydrogen, fluoride, methyl, ethyl, and (C1-C6)haloalkyl;
q is 1, 2, 3, or 4;
r is 1, 2, 3, or 4;
s is 1, 2, 3, or 4;
Ar1 is selected from aryl and heteroaryl which are optionally substituted with 1 to 6 substituents independently selected from the group consisting of: hydrogen, halogen, cyano, nitro, hydroxyl, -C(=O)R7, -C(=O)NR7R8, -NHSO2R7, -SO2NR7R8, (C1-C6)alkylthio-, (C1-C6)haloalkylthio-, (C1-C6)alkylsulfinyl, (C1-C6)alkylsulfonyl, -NR7R8, tri(C1-C6)alkylsilyl, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C1-C6)alkoxy, (C1-C6)alkenyl, aryl(C0-C4)alkyl, heteroaryl(C0-C4)alkyl, aryl(C0-C6)alkoxy, heterocyclyl(C0-C4)alkyl, heterocyclyl(C0-C6)alkoxy, heteroaryl(C0-C6)alkoxy, and substituent group Q;
wherein the said (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C1-C6)alkoxy, (C1-C6)alkenyl, aryl(C0-C4)alkyl, heteroaryl(C0-C4)alkyl, aryl(C0-C6)alkoxy, heterocyclyl(C0-C4)alkyl, heterocyclyl(C0-C6)alkoxy, or heteroaryl(C0-C6)alkoxy is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, cyano, (C1-C6)alkyl, (C3-C7)cycloalkyl (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkoxy, (C1-C6)haloalkoxy, -NRaRb, RaRbN(C1-C6)alkyl, RaRbN(C1-C6)alkoxy, phenyl, -C(=O)NRaRb, -C(=O)Ra, -SO2(C1-C6)alkyl, -SO2NRaRb, and RaRbNC(=O)(C1-C6)alkoxy; wherein the said (C3-C7)cycloalkyl is optionally substituted with hydroxyl or cyano; wherein the substituent group Q is
R7 and R8 are independently selected from the group consisting of: hydrogen, hydroxyl, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C3-C7)cycloalkyl, heterocyclyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)haloalkoxy(C1-C6)alkyl, benzyl, H2N(C1-C6)alkyl, (C1-C6)alkylNH(C1-C6)alkyl, and [(C1-C6)alkyl]2N(C1-C6)alkyl; or R7 and R8, together with nitrogen atom to which they are attached, may form a 3 to 10 membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen; the said 3 to 10 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, oxo, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, -SO2(C1-C6)alkyl, -SO2(C1-C6)haloalkyl, -C(=O)(C1-C6)alkyl, and -C(=O)(C1-C6)haloalkyl;
Ra and Rb are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, (C3-C7)cycloalkyl, phenyl(C0-C6)alkyl, (C1-C6)haloalkoxy(C1-C6)alkyl, H2N(C1-C6)alkyl, (C1-C6)alkylNH(C1-C6)alkyl, and [(C1-C6)alkyl]2N(C1-C6)alkyl; or Ra and Rb, together with nitrogen atom to which they are attached, may form a 3 to 7 membered ring which may contain an atom selected from oxygen, sulfur, and nitrogen; wherein the said 3 to 7 membered ring is optionally substituted with 1 to 3 substituents independently selected from (C1-C6)alkyl;
Ar2 is selected from aryl and heteroaryl which are optionally substituted with 1 to 6 substituents independently selected from the group consisting of: hydrogen, halogen, cyano, nitro, hydroxyl, -COR9, -CONR9R10, -NHSO2R9, -SO2NR9R10, (C1-C6)alkylthio, (C1-C6)alkylsulfinyl, (C1-C6)alkylsulfonyl, -NR9R10, tri(C1-C6)alkylsilyl, (C1-C6)haloalkylthio-, -SF5, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C1-C6)alkoxy, aryl(C0-C4)alkyl, heteroaryl(C0-C4)alkyl, aryl(C0-C6)alkoxy, phenoxy, heteroaryl(C0-C6)alkoxy, heterocyclyl(C0-C4)alkyl, and heterocyclyl(C0-C6)alkoxy; wherein the said (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C1-C6)alkoxy, aryl(C0-C4)alkyl, heteroaryl(C0-C4)alkyl, aryl(C0-C6)alkoxy, phenoxy, heteroaryl(C0-C6)alkoxy, heterocyclyl(C0-C4)alkyl, or heterocyclyl(C0-C6)alkoxy is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, (C1-C6)alkyl, (C3-C7)cycloalkyl (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C6)alkoxy(C1-C6)alkoxy, (C1-C6)haloalkoxy, -NRcRdN, RcRdN(C1-C6)alkyl, RcRdN(C1-C6)alkoxy, -C(=O)NRcRd, RcRdNC(=O)(C1-C6)alkoxy, benzyloxy, and cyano;
R9 and R10 are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)haloalkoxy(C1-C6)alkyl, H2N(C1-C6)alkyl, (C1-C6)alkylNH(C1-C6)alkyl, and [(C1-C6)alkyl]2N(C1-C6)alkyl; or R9 and R10, together with nitrogen atom to which they are attached, may form a 3 to 10 membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen; wherein the said 3 to 10 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, oxo, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, -SO2(C1-C6)alkyl, -SO2(C1-C6)haloalkyl, -C(=O)(C1-C6)alkyl, and -C(=O) (C1-C6)haloalkyl; and
Rc and Rd are independently selected from the group consisting of: hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)haloalkoxy(C1-C6)alkyl, H2N(C1-C6)alkyl, (C1-C6)alkylNH(C1-C6)alkyl, and [(C1-C6)alkyl]2N(C1-C6)alkyl; or Rc and Rd, together with nitrogen atom to which they are attached, may form a 3 to 7 membered ring which may contain a heteroatom selected from oxygen, sulfur, and nitrogen;
or a pharmaceutically acceptable salt thereof. - A compound according to claim 1 to 5, which is selected from the group consisting of:
(R)-2-(1-phenylcyclopropyl)-6-(2-phenylpropanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-2-(1-phenylcyclopropyl)-6-(2-phenylpropanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4-isobutylphenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-6-(2-(4-isobutylphenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-fluorophenyl)cyclopropyl)-6-(2-(4-isobutylphenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(4-isobutylphenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-chlorophenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(4-(trifluoromethyl)phenyl)propanoyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-fluorophenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-isopropylphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)propanoyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-(tert-butyl)phenoxy)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(1H-indol-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(5-fluoro-1H-indol-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(benzo[d]isoxazol-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(5-methyl-2-phenyloxazol-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(3-(3-phenyl-1,2,4-oxadiazol-5-yl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(quinoxalin-6-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2,2-difluoro-2-phenylacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-fluoro-2-phenylacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(5-chloro-1H-benzo[d]imidazol-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-hydroxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-methoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(3-(1H-indol-3-yl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(3-(3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(1H-indazol-1-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
4-(2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one;
(E)-6-(3-(3-chlorophenyl)acryloyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-((1R*,2R*)-2-phenylcyclopropane-1-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-((1R*,2R*)-2-(2,5-difluorophenyl)cyclopropane-1-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-phenylacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-(-)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-(+)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-(-)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-(+)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-(-)-2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-(-)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(-)-2-(1-(4-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(m-tolyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(-)-2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(m-tolyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-6-(2-hydroxy-2-phenylacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,4-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,4-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,6-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-3-phenylpropanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-4-phenylbutanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-fluoro-4-methoxyphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(6-methylpyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-fluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-fluoro-4-methoxyphenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(4-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-(trifluoromethyl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(4-(trifluoromethyl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(trifluoromethyl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(trifluoromethyl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(naphthalen-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-methoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(m-tolyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-4-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-2-yl)cyclopropyl)benzonitrile;
4-(1-(6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-4-oxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-2-yl)cyclopropyl)benzonitrile;
(S)-2-(1-(4-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-hydroxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-bromo-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(p-tolyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(p-tolyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-isopropoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(2-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(2-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(cyclopentyloxy)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3,5-difluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3,5-difluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3,4-difluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3,4-difluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(trifluoromethoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-dichlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3-dichlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(2,2,2-trifluoroethoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-methoxyphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(4-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(m-tolyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(6-methylpyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(oxazol-5-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
3-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)ethyl)benzonitrile;
6-(2-hydroxy-2-(3-(pyrimidin-5-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(2-methoxypyrimidin-5-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(1,3-dimethyl-1H-pyrazol-4-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(oxazol-5-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pyridin-3-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(oxazol-5-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-fluoro-3-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)ethyl)benzonitrile;
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(pyridin-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-benzylcyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-benzylcyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(m-tolyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(2-methylthiazol-4-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiazol-4-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiazol-4-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiazol-5-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiazol-5-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(5-methylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-methylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-methylthiazol-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-methylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-((R)-2-(3-chlorophenyl)-2-hydroxyacetyl)-2-((R/S)-1-phenylethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclobutyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclobutyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclobutyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclobutyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
7-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-d]azepin-4-one;
(R)-7-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-d]azepin-4-one;
(R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7-tetrahydro-4H-pyrrolo[3,4-d]pyrimidin-4-one;
(R)-7-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one;
7-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-8-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
(R)-8-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
6-(2-hydroxy-2-(2-(pyrrolidin-1-yl)pyridin-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(2-(piperidin-1-yl)pyridin-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-(azepan-1-yl)pyridin-4-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-5-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-2-yl)cyclopropyl)thiophene-3-carbonitrile;
4-oxo-2-(1-phenylcyclopropyl)-N-(3-(trifluoromethyl)phenyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-6(4H)-carboxamide;
6-(1H-benzo[d]imidazole-2-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(5,6-difluoro-1H-benzo[d]imidazole-2-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(5,6-difluoro-1H-benzo[d]imidazole-2-carbonyl)-2-(2-phenylpropan-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-benzyl-6-(5,6-difluoro-1H-benzo[d]imidazole-2-carbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(5-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-5-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-isopropylphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(pyridin-4-yl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(pyridin-3-yl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-chloro-3-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-(benzyloxy)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(tetrahydro-2H-pyran-4-yl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(1-methyl-1H-pyrazol-4-yl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(4-hydroxy-2-naphthoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(2-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3-dihydrobenzofuran-7-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-methylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-4-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2,4-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(3-(1H-indol-1-yl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(5-chlorothiophen-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-cyclopropylphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(4-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-chlorophenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chlorophenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(3-hydroxy-3-phenylpropanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(difluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-(tert-butyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3,5-dichlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-(1H-pyrazol-4-yl)thiophen-2-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(5-(trifluoromethyl)pyridin-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-5-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(naphthalen-1-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(naphthalen-1-ylmethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(naphthalen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-8-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
(R)-8-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
(R)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(2-chlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(6-(trifluoromethyl)pyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(2-(trifluoromethyl)pyridin-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(6-chloro-1H-indole-2-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(5-(trifluoromethyl)-1H-benzo[d]imidazole-2-carbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(3-(2-fluorophenyl)-1H-pyrazole-5-carbonyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-chlorophenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(3-(2-chlorophenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-chlorophenoxy)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(2-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(3-(3-chlorophenyl)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chlorophenoxy)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-chloro-3-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-3-(o-tolyloxy)propanoyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3,4-dichlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-acetylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-ethylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-bromothiophen-2-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(6-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-methylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,5-dichlorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(p-tolyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-isopropylphenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(difluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-phenylcyclopropyl)-6-(2-(4-(trifluoromethoxy)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-methoxyphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-chlorothiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-chlorothiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-bromophenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-([1,1'-biphenyl]-4-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(naphthalen-1-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-methylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(2-methylpyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(quinolin-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(4-(pyridin-2-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(3-(trifluoromethoxy)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-([1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(5-methylpyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(4-methylpyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(6-methoxypyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(4'-methyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(2-methylpyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(2-methylpyrimidin-5-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(6-(dimethylamino)pyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(5-chlorothiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-isopropylphenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-isopropylphenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-isopropylphenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(2-phenylpyridin-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-cyclopropylphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(1-methyl-1H-indol-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-ethylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(2-methyl-3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-chloro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-fluoro-5-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-5-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-cycloheptylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(2'-(trifluoromethyl)-[2,4'-bipyridin]-4-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3'-methyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(5-chlorothiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-methyl-5-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-methoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(4'-methoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
3'-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile;
6-(2-(4'-ethoxy-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(4'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(2'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(5,6-dimethylpyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-(difluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(5-bromopyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(prop-1-en-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-ethylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-(1-acetylpiperidin-4-yl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(4,4-difluorocyclohexyl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(6-chloropyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(6-(3-(trifluoromethyl)phenyl)pyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(2'-(trifluoromethyl)-[2,4'-bipyridin]-6-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(6-(3-chlorophenyl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(6-(3-(trifluoromethoxy)phenyl)pyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(piperidin-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(1-methylpiperidin-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-isopropylpyridin-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-((dimethylamino)methyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-acetylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-methoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(1H-benzo[d]imidazole-2-carbonyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(6-(cyclohex-1-en-1-yl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(2,2,2-trifluoroethoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(1'-methyl-1',2',3',6'-tetrahydro-[2,4'-bipyridin]-6-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(6-cyclohexylpyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(2,2,2-trifluoroethoxy)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(6-isopropylpyridin-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-phenylcyclopropyl)-6-(2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-amino-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(2-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-methyl-2-(3-(trifluoromethyl)phenyl)propanoyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-hydroxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3'-((trifluoromethyl)thio)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(2'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(thiazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(3-methoxypropyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenethylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(6-(3-(tert-butyl)phenyl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(6-(3-cyclopropylphenyl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-phenylcyclopropyl)-6-(1-(3-(trifluoromethyl)phenyl)cyclopropane-1-carbonyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)propanoyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(tetrahydro-2H-pyran-4-yl)ethyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-(2-cyclopropylethyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyrimidin-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(trifluoromethyl)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1,1,1-trifluoropropan-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isobutylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(4,4-dimethylcyclohexyl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(3-hydroxy-3-methylbutyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-(3,3-dimethylbutyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N-benzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide;
(R)-N-benzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-dimethylthiophene-3-carboxamide;
1-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)-2-(3-(trifluoromethyl)phenyl)ethane-1,2-dione;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(hydroxymethyl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3',4'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3',5'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2',5'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(oxetan-3-yl)ethyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(trifluoromethyl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(piperidin-1-ylmethyl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)nicotinonitrile;
(R)-2-(1-(3-(6-(dimethylamino)pyridin-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-dimethyl-[1,1'-biphenyl]-3-carboxamide;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-fluoro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-fluoro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(5'-fluoro-2'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2',3'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-chloro-3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-([1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2',4'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(5-bromopyridin-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(5-(3-(trifluoromethyl)phenyl)pyridin-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(5-(3-chlorophenyl)pyridin-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(4-(2-((3S,5S)-adamantan-1-yl)ethyl)thiophen-2-yl)cyclopropyl)-6-((RS)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(trifluoromethoxy)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-methoxypyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3'-((dimethylamino)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(5-(3-fluorophenyl)pyridin-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(2'-(trifluoromethyl)-[3,4'-bipyridin]-5-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(6-(3-fluorophenyl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-sulfonamide;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(4-hydroxytetrahydro-2H-pyran-4-yl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-pyrazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-(difluoromethyl)-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-pyrazol-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-cyclobutyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-dimethyl-[1,1'-biphenyl]-4-sulfonamide;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(oxazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(methylsulfonyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N-cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide;
(R)-N-benzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-isopropylthiophene-3-carboxamide;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(isoindoline-2-carbonyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4''-chloro-[1,1':4',1''-terphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2,3'-difluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(methylamino)pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4'-(dimethylamino)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(pyrrolidin-1-yl)pyrimidin-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)-3-methylbenzo[d]oxazol-2(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(piperidine-1-carbonyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3'-(2-methoxyethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(2-methoxyethoxy)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-methylpiperidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-((4-methylpiperazin-1-yl)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-methoxypyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(1-methylpiperidin-4-yl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-cyclopentylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(5-cyclopentylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(thiazol-5-yl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(pyridin-3-yl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-([3,3'-bipyridin]-5-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-(isothiazol-4-yl)pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(2-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(2-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-phenylacetyl)piperidin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-(3,3-dimethylbutanoyl)piperidin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-benzoylpiperidin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(3-phenylpropanoyl)piperidin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(pyridin-3-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(isothiazol-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(2',3',4',5'-tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(prop-1-en-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-(tetrahydro-2H-pyran-4-yl)pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-(tetrahydro-2H-pyran-4-yl)pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(tetrahydro-2H-pyran-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-([3,3'-bipyridin]-5-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-(isothiazol-4-yl)pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(methylamino)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(pyrrolidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(pyrrolidin-1-ylmethyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(tetrahydro-2H-pyran-4-yl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(pyridin-3-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(tetrahydro-2H-pyran-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(tetrahydro-2H-pyran-4-yl)thiophene-3-carboxamide;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-isopropyl-N-methylthiophene-3-carboxamide;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(piperidine-1-carbonyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(1-hydroxycyclohexyl)ethyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-indazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-indazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-2-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-(4,4-difluorocyclohexyl)pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(5-(4,4-difluorocyclohexyl)pyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(tetrahydro-2H-pyran-4-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(4-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-phenoxypyridin-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(S)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(quinolin-6-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(isoquinolin-6-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(quinolin-7-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(quinolin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(benzofuran-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(4'-(pyridin-2-ylmethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(6-(benzyloxy)pyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)-N,N-dimethylnicotinamide;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(1-(trifluoromethyl)cyclopropane-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4'-chloro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(2-methoxypyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
8-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(tetrahydro-2H-pyran-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3'-chloro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3'-(2-methoxyethoxy)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-isobutyrylpiperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(6-(4-(3,3-dimethylbutanoyl)piperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-(2-phenylacetyl)piperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)picolinonitrile;
(R)-2-(1-(4'-((dimethylamino)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(pyridin-2-ylmethoxy)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-(benzyloxy)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4-(benzyloxy)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-([1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(1-methyl-1H-indazol-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(1-methyl-1H-indazol-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(S)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-([1,1'-biphenyl]-2-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-methyl-1H-indazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-methyl-1H-indazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-1-(3'-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carbonitrile;
(R)-3'-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-sulfonamide;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(4,4-difluorocyclohexyl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-(indolin-1-yl)acetyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-4-(((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)(methyl)amino)-4-oxobutanoic acid;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(2-phenoxypyridin-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(isothiazol-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-(isothiazol-4-yl)pyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-(isothiazol-4-yl)pyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(piperidine-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N-((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)-N-methylpiperidine-1-carboxamide;
(R)-6-(2-(3-(cyclopent-1-en-1-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(naphthalen-1-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(naphthalen-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3',4'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
8,8-difluoro-2-(1-phenylcyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-N,N-dibenzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide;
(R)-N-benzhydryl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(4-phenoxybenzyl)thiophene-3-carboxamide;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(naphthalen-1-ylmethyl)thiophene-3-carboxamide;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-diisopropylthiophene-3-carboxamide;
6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-((trans)-4-(trifluoromethyl)cyclohexane-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-(4-(phenoxymethyl)phenyl)acetyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methylindolin-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(3-(2-oxopyrrolidin-1-yl)propanoyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-(1-(2,2,2-trifluoroethyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-(benzylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-(cyclohexylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-((4-fluorophenyl)sulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(2',3'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-5-chloro-3'-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3',5'-di-tert-butyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzofuran-2-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-2-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzofuran-3-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3',4'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3',5'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(2,3-dihydrobenzofuran-5-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(1-(3-(trifluoromethyl)phenyl)cyclopropane-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-(3-(cyclopentyloxy)-4-methoxybenzoyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N-cyclohexyl-4-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)-3,6-dihydropyridine-1(2H)-carboxamide;
(R)-3-cyclohexyl-1-((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)-1-methylurea;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-phenylpiperidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(6-(4-(benzyloxy)piperidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-4-(2-(((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)(methyl)amino)-2-oxoethyl)benzoic acid;
(R)-4-(((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)(methyl)carbamoyl)bicyclo[2.2.2]octane-1-carboxylic acid;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-(2-(4-(phenoxymethyl)phenyl)acetyl)piperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(6-(benzyloxy)pyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzofuran-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-(trifluoromethyl)pyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-phenyloxazol-5-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N-cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-isopropylthiophene-3-carboxamide;
(R)-N-benzyl-N-cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide;
(R)-N,N-dicyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(naphthalen-2-ylmethyl)thiophene-3-carboxamide;
(R)-N-(tert-butyl)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide;
6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-phenylcyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-phenylcyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzyloxy)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzyloxy)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(S)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(S)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(S)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',4'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(2',3'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(2',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-chloro-3'-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',4'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',5'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(2'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-((trifluoromethyl)thio)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-8-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
(R)-8-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
(R)-8-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
(R)-8-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
(R)-2-(1-(4'-((5-chloro-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4'-((4-(benzyloxy)piperidin-1-yl)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-5-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[d]thiazol-6-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[d]thiazol-2-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-phenyloxazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(5-phenylthiazol-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-5-chloro-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)-1-hydroxy-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2,2-difluoro-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(2'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-2-carbonitrile;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-carbonitrile;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2'-methyl-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-methyl-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-methyl-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3',4'-difluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3',5'-difluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-4-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-3-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-carbonitrile;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3,4-dicarbonitrile;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(2',3',4',5'-tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-isopropylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3,5-dicarbonitrile;
(R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-([1,1'-biphenyl]-4-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)-1-hydroxy-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)-1-hydroxy-2-oxoethyl)-[1,1'-biphenyl]-4-carbonitrile;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-([1,1'-biphenyl]-4-yloxy)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-([1,1'-biphenyl]-3-carbonyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-([1,1'-biphenyl]-4-carbonyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-([1,1'-biphenyl]-3-yloxy)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(3-phenoxybenzoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(4-phenoxybenzoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
8-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
2-(1-phenylcyclopropyl)-8-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-isopropylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethoxy)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(naphthalen-2-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-cyclopropylphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(E)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(3-(3-(trifluoromethyl)phenyl)acryloyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(benzofuran-3-yl)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
5-chloro-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(naphthalen-1-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(3-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzyloxy)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)-2-oxoethyl)-[1,1'-biphenyl]-4-carbonitrile;
6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
3'-(2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)ethyl)-[1,1'-biphenyl]-4-carbonitrile;
6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-phenylcyclopropyl)-6-(2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-phenylcyclopropyl)-6-(2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzofuran-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
5-chloro-3'-(2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)-2-oxoethyl)-[1,1'-biphenyl]-4-carbonitrile;
6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(benzofuran-3-yl)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
5-chloro-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile;
6-(2-(2-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-phenoxyphenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-(benzyloxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzyloxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenoxy)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; and
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(phenylethynyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
or a pharmaceutically acceptable salt thereof. - The compound according to claim 6, which is selected from:
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(2-methoxypyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-methyl-1H-indazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(prop-1-en-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(6-(4-(benzyloxy)piperidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-methoxypyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-5-chloro-3'-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)-1-hydroxy-2-oxoethyl)-[1,1'-biphenyl]-4-carbonitrile;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-chloro-3'-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-2-(1-(3-(4,4-difluorocyclohexyl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(2',3',4',5'-tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-1-(3'-(1-(6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carbonitrile;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(trifluoromethyl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N-cyclohexyl-4-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)-3,6-dihydropyridine-1(2H)-carboxamide;
(R)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(4,4-dimethylcyclohexyl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3'-(2-methoxyethoxy)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(pyrrolidin-1-yl)pyrimidin-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(5-cyclopentylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(2-methoxyethoxy)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-methyl-1H-indazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzofuran-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(1-(3-(trifluoromethyl)phenyl)cyclopropane-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(prop-1-en-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-ethylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',4'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1,1,1-trifluoropropan-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-methoxypyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-phenylcyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(piperidine-1-carbonyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-cycloheptylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-methylpiperidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(pyridin-2-ylmethoxy)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-chloro-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)-1-hydroxy-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(trifluoromethoxy)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzofuran-3-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-(3-(cyclopentyloxy)-4-methoxybenzoyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(cyclopent-1-en-1-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4'-(dimethylamino)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzofuran-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(4,4-difluorocyclohexyl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-4-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isobutylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(3-phenylpropanoyl)piperidin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-cyclobutyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(6-(dimethylamino)pyridin-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-3-cyclohexyl-1-((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)-1-methylurea;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)picolinonitrile;
(R)-6-(2-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)-1-hydroxy-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(5-phenylthiazol-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzofuran-2-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzyloxy)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(6-(benzyloxy)pyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-((trans)-4-(trifluoromethyl)cyclohexane-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)-3-methylbenzo[d]oxazol-2(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(2'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-cyclopentylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
5-chloro-3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)-2-oxoethyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-(methylsulfonyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-((R)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(trifluoromethyl)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[d]thiazol-2-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N-benzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-isopropylthiophene-3-carboxamide;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
5-chloro-3'-(2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)ethyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-2-yl)phenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-(benzylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-(4-(phenoxymethyl)phenyl)acetyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',5'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(isothiazol-4-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(isothiazol-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-(3,3-dimethylbutyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(2'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(pyrrolidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(tetrahydro-2H-pyran-4-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(piperidine-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-diisopropylthiophene-3-carboxamide;
(R)-2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(4-(2-((3S,5S)-adamantan-1-yl)ethyl)thiophen-2-yl)cyclopropyl)-6-((RS)-2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3,4-dicarbonitrile;
6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-((trifluoromethyl)thio)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(6-(3-(trifluoromethyl)phenyl)pyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-carbonitrile;
(R)-3-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-carbonitrile;
6-(2-(3-(benzyloxy)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-phenylpiperidin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-(2-(4-(phenoxymethyl)phenyl)acetyl)piperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(tetrahydro-2H-pyran-4-yl)ethyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-dimethyl-[1,1'-biphenyl]-4-sulfonamide;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzyloxy)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',4'-dimethyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-phenylcyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
8-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
6-(2-hydroxy-2-(6-(3-(trifluoromethoxy)phenyl)pyridin-2-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4'-((4-(benzyloxy)piperidin-1-yl)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(naphthalen-1-ylmethyl)thiophene-3-carboxamide;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-([1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-(3-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)phenyl)nicotinonitrile;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-phenylacetyl)piperidin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-ethylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-methyl-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-(benzyloxy)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-indazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-(difluoromethyl)-1H-pyrazol-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-benzoylpiperidin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4'-(4-hydroxytetrahydro-2H-pyran-4-yl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4'-chloro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
3'-(2-(2-(1-(3-chlorophenyl)cyclopropyl)-4-oxo-3,4,5,7,8,9-hexahydro-6H-pyrimido[5,4-c]azepin-6-yl)-2-oxoethyl)-[1,1'-biphenyl]-4-carbonitrile;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(tetrahydro-2H-pyran-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-(2-cyclopropylethyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-indazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-(cyclohexylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(2',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2'-methyl-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(tetrahydro-2H-pyran-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(methylamino)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methylindolin-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4'-((5-chloro-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenethylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzyloxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(4-phenoxybenzyl)thiophene-3-carboxamide;
(R)-N-benzyl-N-cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3,5-dicarbonitrile;
(R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(1-hydroxycyclohexyl)ethyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-(benzo[d]thiazol-6-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-2-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-N-((3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-4-yl)methyl)-N-methylpiperidine-1-carboxamide;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-fluoro-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-3-carbonitrile;
(R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N-benzhydryl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(naphthalen-2-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N-cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-isopropylthiophene-3-carboxamide;
(R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-(3,3-dimethylbutanoyl)piperidin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3'-isopropoxy-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(1-((4-fluorophenyl)sulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3'-chloro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(2'-(trifluoromethyl)-[2,4'-bipyridin]-6-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N,N-dibenzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide;
2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-(6-(4-(3,3-dimethylbutanoyl)piperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(2-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-5-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-cyclopropylphenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclopentylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(thiazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N,N-dicyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)thiophene-3-carboxamide;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(benzofuran-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(4-(4,4-difluorocyclohexyl)thiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-isopropylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-[1,1'-biphenyl]-2-carbonitrile;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(isothiazol-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(2-(indolin-1-yl)acetyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-chloro-3'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-N-cyclohexyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3'-methyl-[1,1'-biphenyl]-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(5-(3-(trifluoromethyl)phenyl)pyridin-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzofuran-3-yl)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzo[b]thiophen-2-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(3-methoxypropyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-N-benzyl-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methylthiophene-3-carboxamide;
(R)-6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-5-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N-methyl-N-(naphthalen-2-ylmethyl)thiophene-3-carboxamide;
6-(2-(3',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-(trifluoromethyl)pyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(4-(2-(oxetan-3-yl)ethyl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3',5'-difluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-(1-(trifluoromethyl)cyclopropane-1-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-8-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
(R)-2-(1-(3',4'-difluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4'-fluoro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-8-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyridin-3-yl)phenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-isobutyrylpiperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-pyrazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-phenyloxazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-(benzyloxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(1-methyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-chlorophenyl)-2,2-difluoroacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-(tetrahydro-2H-pyran-4-yl)thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-isopropylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-(1-(2,2,2-trifluoroethyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(6-(4-(2-phenylacetyl)piperazin-1-yl)pyridin-3-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(2',3'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(quinolin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(4'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(2',5'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-(benzyloxy)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',5'-di-tert-butyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-(benzo[b]thiophen-2-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-isopropylpyridin-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-([1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-6-(2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(oxazol-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-phenoxyphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-cyclopropylphenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-8-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(2,3-difluorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-chloro-5'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-cyclohexylphenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-isopropyl-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(2',3',4',5'-tetrahydro-[1,1'-biphenyl]-3-yl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(6-(benzyloxy)pyridin-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(E)-2-(1-(3-chlorophenyl)cyclopropyl)-6-(3-(3-(trifluoromethyl)phenyl)acryloyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclopentylthiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(benzo[b]thiophen-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(5-(4,4-difluorocyclohexyl)pyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-(benzofuran-3-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-hydroxy-2-(3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(tert-butyl)phenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(5-(3-chlorophenyl)pyridin-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-4'-methyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-fluorophenyl)cyclopropyl)-6-(2-(3-(trifluoromethyl)phenyl)propanoyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-3'-(1-(6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-4-oxo-4,5,6,7,8,9-hexahydro-3H-pyrimido[5,4-c]azepin-2-yl)cyclopropyl)-N,N-dimethyl-[1,1'-biphenyl]-3-carboxamide;
6-(2-(3-chloro-2-fluorophenyl)-2,2-difluoroacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3'-((trifluoromethyl)thio)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(5-(4,4-difluorocyclohexyl)pyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-(tert-butyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-(benzyloxy)phenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3'-chloro-5'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-(benzo[b]thiophen-3-yl)phenyl)cyclopropyl)-6-(2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one
6-(2-hydroxy-2-(3-((trifluoromethyl)thio)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(naphthalen-1-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(6-(3-cyclopropylphenyl)pyridin-2-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(4''-chloro-[1,1':4',1''-terphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-chlorophenyl)cyclopropyl)-6-(2-(naphthalen-1-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(2-(methylamino)pyridin-4-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-hydroxy-2-(3-(pentafluoro-(lambda)6-sulfaneyl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3',4'-dichloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(3-(trifluoromethyl)phenoxy)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-phenylcyclopropyl)-8-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-c]azepin-4-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(3-(pyrimidin-5-yl)phenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3'-fluoro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-3-yl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3'-cyclopropyl-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(5-(trifluoromethyl)pyridin-3-yl)phenyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-2-(1-(2-phenoxypyridin-4-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(2-fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one; and
6-(2-(2-fluoro-3-(2-(trifluoromethyl)pyridin-4-yl)phenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
or a pharmaceutically acceptable salt thereof. - A single enantiomer of a compound selected from the group consisting of:
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-(3-fluorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-hydroxy-2-(m-tolyl)acetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-bromo-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
6-(2-(3-chloro-2-fluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-fluoro-3-(1-hydroxy-2-oxo-2-(4-oxo-2-(1-phenylcyclopropyl)-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)ethyl)benzonitrile;
6-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; and
6-(2-hydroxy-2-(m-tolyl)acetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
or a pharmaceutically acceptable salt thereof. - A pharmaceutical composition comprising a compound, or a pharmaceutically acceptable salt thereof, according to any one of claims 1 to 8, and a pharmaceutically acceptable carrier.
- The pharmaceutical composition according to claim 9, further comprising another pharmacologically active agent.
- A method for the treatment of a condition or disorder mediated by TRPV4 receptor antagonistic activity, in an animal including a human, which comprises administering to an animal in need of such treatment a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt thereof, according to any one of claims 1 to 8.
- The method according to claim 11, wherein said condition or disorder is one or more selected from the group consisting of: inflammatory, pain, and urological diseases or disorders, and combinations thereof.
- The method according to claim 11, wherein said condition or disorder is one or more selected from the group consisting of: chronic pain; neuropathic pain including diabetic neuropathy; postoperative pain; osteoarthritis; rheumatoid arthritic pain; cancer pain; neuralgia; neuropathies; algesia, nerve injury; migraine; cluster and tension headaches; ischaemia; irritable bowel syndrome; inflammatory bowel disease; neurodegeneration; fibromyalgia; stroke; itch; psychiatric disorders including anxiety, anxiety for other stress-related disorders and depression; inflammatory disorders including asthma, chronic obstructive pulmonary disease (COPD) and chronic obstructive airway disease (COAD); pulmonary hypertension; and urological diseases or disorders including detrusor overactivity or overactive bladder, urinary incontinence, neurogenic detrusor overactivity or detrusor hyperflexia, idiopathic detrusor overactivity or detrusor instability, benign prostatic hyperplasia, and lower urinary tract symptoms; and combinations thereof.
- A compound according to any one of claims 1 to 8, or a pharmaceutically acceptable salt thereof for use in the treatment of a condition or disorder mediated by TRPV4 receptor antagonistic activity.
- A use of a compound according to any one of claims 1 to 8 or a pharmaceutically acceptable salt, solvate, or composition thereof for the manufacture of a medicament for the treatment of a condition or disorder mediated by TRPV4 receptor antagonistic activity.
- The use according to claim 15, wherein said condition or disorder is one or more selected form the group consisting of: inflammatory, pain, and urological diseases or disorders, and combinations thereof.
- The use according to claim 15, wherein said condition or disorder is one or more selected form the group consisting of: chronic pain; neuropathic pain including diabetic neuropathy; postoperative pain; osteoarthritis; rheumatoid arthritic pain; cancer pain; neuralgia; neuropathies; algesia, nerve injury; migraine; cluster and tension headaches; ischaemia; irritable bowel syndrome; inflammatory bowel disease; neurodegeneration; fibromyalgia; stroke; itch; psychiatric disorders including anxiety, anxiety for other stress-related disorders and depression; inflammatory disorders including asthma, chronic obstructive pulmonary disease (COPD) and chronic obstructive airway disease (COAD); pulmonary hypertension; and urological diseases or disorders including detrusor overactivity or overactive bladder, urinary incontinence, neurogenic detrusor overactivity or detrusor hyperflexia, idiopathic detrusor overactivity or detrusor instability, benign prostatic hyperplasia, and lower urinary tract symptoms; and combinations thereof.
- A process for preparing a pharmaceutical composition comprising mixing a compound or a pharmaceutically acceptable salt thereof, according to any one of claims 1 to 8, and a pharmaceutically acceptable carrier or excipient.
- A compound represented by the following formula (I-d):
R1 and R2 are independently selected from the group consisting of: hydrogen, hydroxyl, halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxyl, (C1-C6)haloalkoxy, (C3-C7)cycloalkyl, and phenyl(C0-C4)alkyl; wherein the said (C3-C7)cycloalkyl or phenyl(C0-C4)alkyl is optionally substituted with 1 to 4 substituents independently selected from the group consisting of: halogen, hydroxyl, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, and (C1-C6)haloalkoxy; or alternatively R1 and R2, together with the atom to which they are attached, may form a 3 to 8 membered ring which may contain 0 to 4 heteroatoms independently selected from oxygen, sulfur, and nitrogen; wherein the said 3 to 8 membered ring is optionally substituted with 1 to 6 substituents independently selected from the group consisting of: halogen, hydroxyl, (C1-C6)alkyl, (C1-C6)haloalkyl, -SO2(C1-C6)alkyl, -SO2(C1-C6)haloalkyl, -C(=O)(C1-C6)alkyl, and -C(=O)(C1-C6)haloalkyl;
R3 is independently selected from the group consisting of: hydrogen, fluoride, methyl, ethyl, and (C1-C6)haloalkyl;
q is 1, 2, 3, or 4;
r is 1, 2, 3, or 4;
s is 1, 2, 3, or 4;
or a pharmaceutically acceptable salt thereof. - A compound which is selected from the group consisting of:
(R)-2-(1-(5-bromopyridin-3-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(3-bromophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(5-bromopyridin-3-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-2-(1-(4-bromothiophen-2-yl)cyclopropyl)-6-(2-(3-chlorophenyl)-2-hydroxyacetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(3-bromophenyl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(2-bromopyridin-4-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-2-(1-(6-bromopyridin-2-yl)cyclopropyl)-6-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-phenylcyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-isopropylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(4-isopropylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(5-isopropylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(5-phenylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-bromophenyl)acetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-cyclohexylphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-bromophenyl)-2,2-difluoroacetyl)-2-(1-phenylcyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(thiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(3-phenoxyphenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(4-phenylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-bromophenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(4-cyclohexylthiophen-2-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
(R)-6-(2-(3-bromophenyl)-2-hydroxyacetyl)-2-(1-(5-cyclohexylpyridin-3-yl)cyclopropyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
6-(2-(3-bromophenyl)acetyl)-2-(1-(3-chlorophenyl)cyclopropyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[5,4-c]azepin-4-one;
2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one; and
2-(1-(3-bromophenyl)cyclopropyl)-6-(2-(3'-chloro-[1,1'-biphenyl]-3-yl)acetyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;
or a pharmaceutically acceptable salt thereof.
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MX2022013607A MX2022013607A (en) | 2020-04-30 | 2021-04-30 | Pyrimidin-4(3h)-one derivatives as trpv4 antagonists. |
US17/921,203 US20230339934A1 (en) | 2020-04-30 | 2021-04-30 | Pyrimidin-4(3h)-one derivatives as trpv4 antagonists |
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WO2011119704A1 (en) * | 2010-03-23 | 2011-09-29 | Glaxosmithkline Llc | Trpv4 antagonists |
JP5819397B2 (en) | 2010-03-23 | 2015-11-24 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC | TRPV4 antagonist |
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- 2021-04-30 US US17/921,203 patent/US20230339934A1/en active Pending
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- 2021-04-30 KR KR1020227040115A patent/KR20230005227A/en active Search and Examination
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WO2015046193A1 (en) * | 2013-09-25 | 2015-04-02 | 塩野義製薬株式会社 | Aromatic heterocyclic amine derivative having trpv4 inhibiting activity |
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DATABASE REGISTRY 10 August 2005 (2005-08-10), ANONYMOUS: "/1 -(C) FILE REGISTRY RN -859481-30-4 REGISTRY ED -Entered STN: 10 Aug 2005 CN -Pyrido[4,3-d]pyrimidin-4(3H)-one, 5,6,7,8-tetrahydro-6-(4-methylbenzoyl)-2- [(2-methylphenyl)methyl]-(CA INDEX NAME)", XP055862077, retrieved from STN Database accession no. 859481-30-4 * |
See also references of EP4142874A1 * |
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TW202206430A (en) | 2022-02-16 |
EP4142874A1 (en) | 2023-03-08 |
KR20230005227A (en) | 2023-01-09 |
BR112022019628A2 (en) | 2022-11-16 |
CN115427409A (en) | 2022-12-02 |
US20230339934A1 (en) | 2023-10-26 |
CA3180132A1 (en) | 2021-10-30 |
MX2022013607A (en) | 2022-11-16 |
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