WO2021178886A1 - Coronavirus disease (covid-19) vaccine - Google Patents

Abstract

The present invention includes a vaccine comprising a SARS-CoV-2 spike protein (S) or portion thereof, and methods of use thereof.

Description

CORONA VIRUS DISEASE (COVID-19) VACCINE

CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to U.S. Provisional Application No. 62/986,396 filed March 6, 2020 and to U.S. Provisional Application No. 63/017,241 filed April 29, 2020, each of which is herein incorporated by reference in its entirety.

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR

DEVELOPMENT

This invention was made with government support under grant no. 1R21AI158044-01 awarded by the National Institute of Health. The government has certain rights in the invention.

REFERENCE TO SEQUENCE LISTING The Sequence Listing concurrently submitted herewith as a text file named "205961_7055W01_Sequence_Listing.txt," created on March 4, 2021 and having a size of 577,339 bytes is herein incorporated by reference pursuant to 37 C.F.R. § 1.52(e)(5).

BACKGROUND OF THE INVENTION The recently emerged coronavirus, currently called 2019-nCoV or SARS-CoV-2 virus, is rapidly spreading in China and Asia with over 42,000 cases, 500 deaths and cases in 18 countries as of February 10, 2020. This novel coronavirus is thought to have emerged from a live animal market in Wuhan, China, and has quickly spread in the community with large clusters of human to human transmission. The sequence of several isolates have been determined, and the closest strains are SARS-like bat coronavirus lineages. Little is known about this virus including its susceptibility to anti-viral compounds, ability to replicate in cell lines or host factors regulating replication. Importantly there are no therapeutics available to treat the virus, although investigational studies are underway. Modeling of the current outbreak suggests that the virus could infect >1 billion people and become a yearly epidemic.

A need exists for novel methods for generating vaccines to treat Coronaviruses, in particular, COVID-19. The present invention addresses and satisfies this need.

SUMMARY OF THE INVENTION In some aspects, the present disclosure provides an isolated nucleic acid encoding a recombinant virus comprising a SARS-CoV-2 spike protein (S) or a portion thereof.

In other aspects, the present disclosure provides a recombinant virus comprising a SARS-CoV-2 spike protein (S) or a portion thereof.

In one aspect, the present disclosure provides a recombinant virus encoded by a nucleic acid described herein. In some embodiments, the nucleic acid encodes a recombinant virus comprising a SARS-CoV-2 spike protein (S) or a portion thereof.

In another aspect, the present disclosure provides a recombinant fusion protein comprising (a) a glycoprotein (G) of a virus or a portion thereof, and (b) a SARS-CoV-2 spike protein (S) or a portion thereof.

In some aspects, the present disclosure provides a vector comprising a nucleic acid described herein. In one embodiment, the nucleic acid encodes a recombinant virus comprising a SARS-CoV-2 spike protein (S) or a portion thereof.

In other aspects, the present disclosure provides a vaccine comprising a recombinant virus comprising a SARS-CoV-2 spike protein (S) or a portion thereof, and a pharmaceutically acceptable carrier.

In one aspect, the present disclosure provides a method of generating an immune response against a SARS-CoV-2 virus in a subject in need thereof, the method comprising administering to the subject an effective amount of a vaccine described herein. In some embodiments, the vaccine comprises a recombinant virus comprising a SARS-CoV-2 spike protein (S) or a portion thereof, and a pharmaceutically acceptable carrier.

In another aspect, the present disclosure provides a method of vaccinating a subject against a SARS-CoV-2 virus, the method comprising administering to the subject an effective amount of the vaccine described herein. In some embodiments, the vaccine comprises a recombinant virus comprising a SARS-CoV-2 spike protein (S) or a portion thereof, and a pharmaceutically acceptable carrier.

In other aspects, the present disclosure provides a method of providing immunity against a SARS-CoV-2 virus in a subject, the method comprising administering to the subject an effective amount of the vaccine described herein. In some embodiments, the vaccine comprises a recombinant virus comprising a SARS-CoV-2 spike protein (S) or a portion thereof, and a pharmaceutically acceptable carrier.

In some aspects, the present disclosure provides a method of treating and/or preventing a disease or disorder associated with a SARS-CoV-2 virus in a subject in need thereof, the method comprising administering to the subject an effective amount of the vaccine described herein. In some embodiments, the vaccine comprises a recombinant virus comprising a SARS-CoV-2 spike protein (S) or a portion thereof, and a pharmaceutically acceptable carrier.

BRIEF DESCRIPTION OF THE DRAWINGS

The following detailed description of specific embodiments of the invention will be better understood when read in conjunction with the appended drawings. For the purpose of illustrating the invention, there are shown in the drawings exemplary embodiments. It should be understood, however, that the invention is not limited to the precise arrangements and instrumentalities of the embodiments shown in the drawings.

FIG. 1: VSV expressing codon-optimized Covid-Sl. The map shows the viral sequence including the plasmids utilized to create the recombinant virus. The sequence is shown in SEQ ID NO: 1 and features are shown in FIG. 7. The sequence and features are also shown in FIG. 17 (“VSV-COVID19-S1-VSVG”).

FIG 2: RABV expressing codon-optimized Covid-Sl. The map shows the viral sequence, including the plasmids utilized to create the recombinant virus. The sequence is shown in SEQ ID NO: 2 and features are shown in FIG. 8. The sequence and features are also shown in FIG. 18 (“BN8R333-Oqnΐϋ19-81-Bnq”).

FIG. 3: MV expressing codon-optimized Covid-S from position 2 of the genome. The map shows the viral sequence, including the plasmids utilized to create the recombinant virus. The sequences is shown in SEQ ID NO: 3 and features are shown in FIG. 9. The sequence and features are also shown in FIG. 21 (“MV-coWuhan-S Position 2”).

FIG. 4: MV expressing codon-optimized Covid-S from position 3 of the genome. The map shows the viral sequence, including the plasmids utilized to create the recombinant virus. The sequence is shown in SEQ ID NO: 4 and features are shown in FIG. 10. The sequence and features are also depicted in FIG. 20 (“MV Wu S in position 3”).

FIG. 5: MV expressing codon-optimized Covid-S from position 6 of the genome. The map shows the viral sequence, including the plasmids utilized to create the recombinant virus. The sequence is shown in SEQ ID NO: 5 and features are shown in FIG. 11. The sequence and features are also depicted in FIG. 19 (“MV WuhanCoV S in position 6”). FIG. 6: Characterization of RABV (RABV-COV19-S1) and VSV (VSV-COV19- Sl) expressing a chimeric Sl-G fusion protein. SDS-PAGE analysis of purified virions after sucrose gradient purification. Letters indicate the positions of the VSV or RABV L, G, N, P, and M proteins. Numbers to the left indicate the sizes of the molecular mass standards. The Covid-19 SI protein is indicated. The controls show VSV and RABV virions.

FIG. 7 shows the features of the map shown in FIG. 1.

FIG. 8 shows the features of the map shown in FIG. 2.

FIG. 9 shows the features of the map shown in FIG. 3.

FIG. 10 shows the features of the map shown in FIG. 4.

FIG. 11 shows the features of the map shown in FIG. 5.

FIG. 12: Schematic illustration of the 2019-nCoV vaccine constructs used in this study. Spike protein cDNA is inserted between the N and P genes of the SAD-B19- derived RABV virus vaccine vector BNSP333. The BNSP333-S1-G construct expresses a chimeric protein that contains the entire SI domain fused to the C-terminal part of the RABV G glycoprotein (amino acids 428-524), which encompasses the entire cytoplasmic domain (CD), the transmembrane domain (TM), plus 31 amino acids of the ectodomain (E31) of RABV G. Different structural elements of the spike protein are indicated in the full length construct: signal peptide (SP), receptor-binding domain (RBD), fusion peptide (FP), heptad repeat regions 1 and 2 (HR1 and HR2), transmembrane domain (TM), and cytoplasmic domain (CD).

FIG. 13: Schematic illustration of the MERSRAB immunization schedule and challenge with MERS-CoV. Two and three immunization were analyzed with the deactivated vaccine.

FIGs. 14A-14C: Two or three inoculation with MERSRAB protect animals from weight loss and vaccine induce immune responses control the MERS-CoV challenge viruses to undetectable levels. Animals were immunized and challenge as outlined in FIG. 13.

FIG. 15: Two or three inoculation with MERSRAB protect animals from viral replication in the lung. The figure shows that only small amounts of MERS-CoV antigen is detected in lungs of immunized mice at day three after challenge, and no antigen is detected at day six. In contrast, in the lung tissue of animal immunized with the rabies virus vector only large amount of tissue damage and viral antigen can be detected at both time points consistent with the viral load shown in FIG. 14. FIGs. 16A-16B: FIG. 16A is a presentation showing formulation of BBV151-A vaccine (BBV151-A1 & BBV151-A2) and FIG.16B is a presentation showing formulation of BBV-151-B vaccine.

FIG. 17 shows the sequence and features of “VSV-COVID19-S1-VSVG.

FIG. 18 shows the sequence and features of “BNSP333-COVID19-S1-RVG”.

FIG. 19 shows the sequence and features of “MV WuhanCoV S in position 6”. FIG. 20 shows the sequence and features of “MV Wu S in position 3”.

FIG. 21 shows the sequence and features of “MV-coWuhan-S Position 2”.

DETAILED DESCRIPTION

Definitions

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the invention pertains. Although any methods and materials similar or equivalent to those described herein may be used in the practice for testing of the present invention, the preferred materials and methods are described herein. In describing and claiming the present invention, the following terminology will be used.

It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to be limiting.

As used herein, the articles “a” and “an” are used to refer to one or to more than one (i.e., to at least one) of the grammatical object of the article. By way of example, “an element” means one element or more than one element.

The term “antibody” or “Ab” as used herein, refers to a protein, or polypeptide sequence derived from an immunoglobulin molecule, which specifically binds to a specific epitope on an antigen. Antibodies can be intact immunoglobulins derived from natural sources or from recombinant sources and can be immunoreactive portions of intact immunoglobulins. The antibodies useful in the present invention may exist in a variety of forms including, for example, polyclonal antibodies, monoclonal antibodies, intracellular antibodies (“intrabodies”), Fv, Fab and F(ab)2, as well as single chain antibodies (scFv) and humanized antibodies (Harlow et al., 1998, Using Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory Press, NY; Harlow et al., 1989, Antibodies: A Laboratory Manual, Cold Spring Harbor, New York; Houston et al., 1988, Proc. Natl. Acad. Sci. USA 85:5879-5883; Bird et al., 1988, Science 242:423-426). An antibody may be derived from natural sources or from recombinant sources. Antibodies are typically tetramers of immunoglobulin molecules.

The term “ameliorating” or “treating” means that the clinical signs and/or the symptoms associated with a disease are lessened as a result of the actions performed. The signs or symptoms to be monitored will be well known to the skilled clinician.

As used herein when referring to a measurable value such as an amount, a temporal duration, and the like, the term “about” is meant to encompass variations of ±20% or ±10%, more preferably ±5%, even more preferably ±1%, and still more preferably ±0.1% from the specified value, as such variations are appropriate to perform the disclosed methods.

The term “biological” or “biological sample” refers to a sample obtained from an organism or from components (e.g., cells) of an organism. The sample may be of any biological tissue or fluid. Frequently the sample will be a “clinical sample” which is a sample derived from a patient. Such samples include, but are not limited to, bone marrow, cardiac tissue, sputum, blood, lymphatic fluid, blood cells (e.g., white cells), tissue or fine needle biopsy samples, urine, peritoneal fluid, and pleural fluid, or cells therefrom. Biological samples may also include sections of tissues such as frozen sections taken for histological purposes.

As used herein, the terms "control," or " reference " are used interchangeably and refer to a value that is used as a standard of comparison.

The term “ immunogenicity” as used herein, refers to the innate ability of an antigen or organism to elicit an immune response in an animal when the antigen or organism is administered to the animal. Thus, "enhancing the immunogenicity" refers to increasing the ability of an antigen or organism to elicit an immune response in an animal when the antigen or organism is administered to an animal. The increased ability of an antigen or organism to elicit an immune response can be measured by, among other things, a greater number of antibodies that bind to an antigen or organism, a greater diversity of antibodies to an antigen or organism, a greater number of T-cells specific for an antigen or organism, a greater cytotoxic or helper T-cell response to an antigen or organism, a greater expression of cytokines in response to an antigen, and the like.

As used herein, the terms “eliciting an immune response” or “immunizing” refer to the process of generating a B cell and/or a T cell response against a heterologous protein. The term “antigen” or “Ag” as used herein is defined as a molecule that provokes an immune response. This immune response may involve either antibody production, or the activation of specific immunologically-competent cells, or both. The skilled artisan will understand that any macromolecule, including virtually all proteins or peptides, can serve as an antigen. Furthermore, antigens can be derived from recombinant or genomic DNA. A skilled artisan will understand that any DNA, which comprises a nucleotide sequences or a partial nucleotide sequence encoding a protein that elicits an immune response therefore encodes an “antigen” as that term is used herein. Furthermore, one skilled in the art will understand that an antigen need not be encoded solely by a full- length nucleotide sequence of a gene. It is readily apparent that the present invention includes, but is not limited to, the use of partial nucleotide sequences of more than one gene and that these nucleotide sequences are arranged in various combinations to elicit the desired immune response. Moreover, a skilled artisan will understand that an antigen need not be encoded by a “gene” at all. It is readily apparent that an antigen can be generated synthesized or can be derived from a biological sample. Such a biological sample can include, but is not limited to a tissue sample, a tumor sample, a cell or a biological fluid.

“Heterologous antigens” used herein to refer to an antigen that is not endogenous to the organism comprising or expressing an antigen. As an example, a virus vaccine vector comprising or expressing a viral or tumor antigen comprises a heterologous antigen. The term “Heterologous protein” as used herein refers to a protein that elicits a beneficial immune response in a subject (i.e. mammal), irrespective of its source.

The term “specifically binds”, “selectively binds” or “binding specificity” refers to the ability of the humanized antibodies or binding compounds of the invention to bind to a target epitope with a greater affinity than that which results when bound to a non target epitope. In certain embodiments, specific binding refers to binding to a target with an affinity that is at least 10, 50, 100, 250, 500, or 1000 times greater than the affinity for a non-target epitope.

As used herein, by “combination therapy” is meant that a first agent is administered in conjunction with another agent. “In combination with” or “In conjunction with” refers to administration of one treatment modality in addition to another treatment modality. As such, “in combination with” refers to administration of one treatment modality before, during, or after delivery of the other treatment modality to the individual. Such combinations are considered to be part of a single treatment regimen or regime.

“Humoral immunity” or “humoral immune response” both refer to B-cell mediated immunity and are mediated by highly specific antibodies, produced and secreted by B-lymphocytes (B-cells).

“Prevention” refers to the use of a pharmaceutical compositions for the vaccination against a disorder.

“Adjuvant” refers to a substance that is capable of potentiating the immunogenicity of an antigen. Adjuvants can be one substance or a mixture of substances and function by acting directly on the immune system or by providing a slow release of an antigen. Examples of adjuvants include, but are not limited to, emulsions ( e.g oil in water (o/w) emulsions), aluminium salts, polyanions, bacterial glycopeptides and slow release agents such as Freund's incomplete.

“Delivery vehicle” refers to a composition that helps to target the antigen to specific cells and to facilitate the effective recognition of an antigen by the immune system. The best-known delivery vehicles are liposomes, virosomes, microparticles including microspheres and nanospheres, polymers, bacterial ghosts, bacterial polysaccharides, attenuated bacteria, virus like particles, attenuated viruses and ISCOMS.

The term “expression” as used herein is defined as the transcription and/or translation of a particular nucleotide sequence driven by its promoter.

As used herein, the term “expression cassette” means a nucleic acid sequence capable of directing the transcription and/or translation of a heterologous coding sequence. In some embodiments, the expression cassette comprises a promoter sequence operably linked to a sequence encoding a heterologous protein. In some embodiments, the expression cassette further comprises at least one regulatory sequence operably linked to the sequence encoding the heterologous protein.

“Incorporated into” or “encapsulated in” refers to an antigenic peptide and/or nucleic acid molecule that is/are within a delivery vehicle, such as microparticles, bacterial ghosts, attenuated bacteria, virus like particles, attenuated viruses, ISCOMs, liposomes and preferably virosomes.

As used herein, the terms “peptide,” “polypeptide,” and “protein” are used interchangeably, and refer to a compound comprised of amino acid residues covalently linked by peptide bonds. A protein or peptide must contain at least two amino acids, and no limitation is placed on the maximum number of amino acids that may comprise a protein or peptide’s sequence. Polypeptides include any peptide or protein comprising two or more amino acids joined to each other by peptide bonds. As used herein, the term refers to both short chains, which also commonly are referred to in the art as peptides, oligopeptides and oligomers, for example, and to longer chains, which generally are referred to in the art as proteins, of which there are many types. “Polypeptides” include, for example, biologically active fragments, substantially homologous polypeptides, oligopeptides, homodimers, heterodimers, variants of polypeptides, modified polypeptides, derivatives, analogs, fusion proteins, among others. The polypeptides include natural peptides, recombinant peptides, synthetic peptides, or a combination thereof.

A "fusion protein" as used herein refers to a protein wherein the protein comprises two or more proteins linked together by peptide bonds or other chemical bonds. The proteins can be linked together directly by a peptide or other chemical bond, or with one or more amino acids between the two or more proteins, referred to herein as a spacer.

In the context of the present invention, the following abbreviations for the commonly occurring nucleic acid bases are used. “A” refers to adenosine, “C” refers to cytosine, “G” refers to guanosine, “T” refers to thymidine, and “U” refers to uridine.

The term “RNA” as used herein is defined as ribonucleic acid.

"Transform", "transforming", and "transformation "is used herein to refer to a process of introducing an isolated nucleic acid into the interior of an organism.

The term “treatment” as used within the context of the present invention is meant to include therapeutic treatment as well as prophylactic, or suppressive measures for the disease or disorder. As used herein, the term “treatment” and associated terms such as “treat” and “treating” means the reduction of the progression, severity and/or duration of a disease condition or at least one symptom thereof. The term ‘treatment’ therefore refers to any regimen that can benefit a subject. The treatment may be in respect of an existing condition or may be prophylactic (preventative treatment). Treatment may include curative, alleviative or prophylactic effects. References herein to “therapeutic” and “prophylactic” treatments are to be considered in their broadest context. The term “therapeutic” does not necessarily imply that a subject is treated until total recovery. Similarly, “prophylactic” does not necessarily mean that the subject will not eventually contract a disease condition. Thus, for example, the term treatment includes the administration of an agent prior to or following the onset of a disease or disorder thereby preventing or removing all signs of the disease or disorder. As another example, administration of the agent after clinical manifestation of the disease to combat the symptoms of the disease comprises “treatment” of the disease.

The term “equivalent,” when used in reference to nucleotide sequences, is understood to refer to nucleotide sequences encoding functionally equivalent polypeptides. Equivalent nucleotide sequences will include sequences that differ by one or more nucleotide substitutions, additions- or deletions, such as allelic variants; and will, therefore, include sequences that differ from the nucleotide sequence of the nucleic acids described herein due to the degeneracy of the genetic code.

The term “isolated” as used herein with respect to nucleic acids, such as DNA or RNA, refers to molecules separated from other DNAs or RNAs, respectively that are present in the natural source of the macromolecule. The term isolated as used herein also refers to a nucleic acid or peptide that is substantially free of cellular material, viral material, or culture medium when produced by recombinant DNA techniques, or chemical precursors or other chemicals when chemically synthesized. Moreover, an “isolated nucleic acid” is meant to include nucleic acid fragments, which are not naturally occurring as fragments and would not be found in the natural state. The term “isolated” is also used herein to refer to polypeptides, which are isolated from other cellular proteins and is meant to encompass both purified and recombinant polypeptides. An “isolated cell” or “isolated population of cells” is a cell or population of cells that is not present in its natural environment.

“Identity” as used herein refers to the subunit sequence identity between two polymeric molecules particularly between two amino acid molecules, such as, between two polypeptide molecules. When two amino acid sequences have the same residues at the same positions; e.g ., if a position in each of two polypeptide molecules is occupied by an Arginine, then they are identical at that position. The identity or extent to which two amino acid sequences have the same residues at the same positions in an alignment is often expressed as a percentage. The identity between two amino acid sequences is a direct function of the number of matching or identical positions; e.g. , if half (e.g, five positions in a polymer ten amino acids in length) of the positions in two sequences are identical, the two sequences are 50% identical; if 90% of the positions (e.g, 9 of 10), are matched or identical, the two amino acids sequences are 90% identical.

A “mutation” as used therein is a change in a DNA sequence resulting in an alteration from its natural state. The mutation can comprise a deletion and/or insertion and/or duplication and/or substitution of at least one deoxyribonucleic acid base such as a purine (adenine and/or thymine) and/or a pyrimidine (guanine and/or cytosine).

Mutations may or may not produce discernible changes in the observable characteristics (phenotype) of an organism.

As used herein, the term “nucleic acid” refers to polynucleotides such as deoxyribonucleic acid (DNA), and, where appropriate, ribonucleic acid (RNA). The term should also be understood to include, as equivalents, analogs of either RNA or DNA made from nucleotide analogs, and, as applicable to the embodiment being described, single (sense or antisense) and double-stranded polynucleotides. ESTs, chromosomes, cDNAs, mRNAs, and rRNAs are representative examples of molecules that may be referred to as nucleic acids. As used herein, nucleic acids include but are not limited to, all nucleic acid sequences which are obtained by any means available in the art, including, without limitation, recombinant means, i.e., the cloning of nucleic acid sequences from a recombinant library or a viral genome, using ordinary cloning technology and PCR™, and the like, and by synthetic means.

In the context of the present invention, the following abbreviations for the commonly occurring nucleic acid bases are used. “A” refers to adenosine, “C” refers to cytosine, “G” refers to guanosine, “T” refers to thymidine, and “U” refers to uridine.

As used herein, "operably linked" sequences include both expression control sequences that are contiguous with the gene of interest and expression control sequences that act in trans or at a distance to control the gene of interest. Expression control sequences include appropriate transcription initiation, termination, promoter and enhancer sequences; efficient RNA processing signals such as splicing and polyadenylation (poly A) signals; sequences that stabilize cytoplasmic mRNA; sequences that enhance translation efficiency (i.e., Kozak consensus sequence); sequences that enhance protein stability; and when desired, sequences that enhance secretion of the encoded product. There are numerous expression control sequences, including promoters which are native, constitutive, inducible and/or tissue-specific, are known in the art that may be used in the compositions of the invention. “Operably linked” should be construed to include RNA expression and control sequences in addition to DNA expression and control sequences.

The term “promoter” as used herein is defined as a DNA sequence recognized by the synthetic machinery of the cell, or introduced synthetic machinery, required to initiate the specific transcription of a polynucleotide sequence. As used herein, the term “promoter/regulatory sequence” means a nucleic acid sequence, which is required for expression of a gene product operably linked to the promoter/regulatory sequence. In some instances, this sequence may be the core promoter sequence and in other instances, this sequence may also include an enhancer sequence and other regulatory elements, which are required for expression of the gene product. The promoter/regulatory sequence may, for example, be one which expresses the gene product in a tissue specific manner.

A “constitutive” promoter is a nucleotide sequence which, when operably linked with a polynucleotide which encodes or specifies a gene product, causes the gene product to be produced in a cell under most or all physiological conditions of the cell.

An “inducible” promoter is a nucleotide sequence which, when operably linked with a polynucleotide which encodes or specifies a gene product, causes the gene product to be produced in a cell substantially only when an inducer which corresponds to the promoter is present in the cell.

As used herein, the term “pharmaceutical composition” refers to a mixture of at least one compound useful within the invention with other chemical components, such as carriers, stabilizers, diluents, adjuvants, dispersing agents, suspending agents, thickening agents, and/or excipients. The pharmaceutical composition facilitates administration of the compound to an organism. Multiple techniques of administering a compound exist in the art including, but not limited to: intravenous, oral, aerosol, parenteral, ophthalmic, pulmonary and topical administration.

The language “pharmaceutically acceptable carrier” includes a pharmaceutically acceptable salt, pharmaceutically acceptable material, composition or carrier, such as a liquid or solid filler, diluent, excipient, solvent or encapsulating material, involved in carrying or transporting a compound(s) of the present invention within or to the subject such that it may perform its intended function. Typically, such compounds are carried or transported from one organ, or portion of the body, to another organ, or portion of the body. Each salt or carrier must be “acceptable” in the sense of being compatible with the other ingredients of the formulation, and not injurious to the subject. Some examples of materials that may serve as pharmaceutically acceptable carriers include: sugars, such as lactose, glucose and sucrose; starches, such as corn starch and potato starch; cellulose, and its derivatives, such as sodium carboxymethyl cellulose, ethyl cellulose and cellulose acetate; powdered tragacanth; malt; gelatin; talc; excipients, such as cocoa butter and suppository waxes; oils, such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil and soybean oil; glycols, such as propylene glycol; polyols, such as glycerin, sorbitol, mannitol and polyethylene glycol; esters, such as ethyl oleate and ethyl laurate; agar; buffering agents, such as magnesium hydroxide and aluminum hydroxide; alginic acid; pyrogen-free water; isotonic saline; Ringer’s solution; ethyl alcohol; phosphate buffer solutions; diluent; granulating agent; lubricant; binder; disintegrating agent; wetting agent; emulsifier; coloring agent; release agent; coating agent; sweetening agent; flavoring agent; perfuming agent; preservative; antioxidant; plasticizer; gelling agent; thickener; hardener; setting agent; suspending agent; surfactant; humectant; carrier; stabilizer; and other non-toxic compatible substances employed in pharmaceutical formulations, or any combination thereof. As used herein, “pharmaceutically acceptable carrier” also includes any and all coatings, antibacterial and antifungal agents, and absorption delaying agents, and the like that are compatible with the activity of the compound, and are physiologically acceptable to the subject. Supplementary active compounds may also be incorporated into the compositions.

As used herein, the term “effective amount” or “therapeutically effective amount” means that amount of a composition ( e.g ., vaccine composition) or active ingredient (e.g., virus like particles (VLPs), virions, viral vectors, antigen, nucleic acid molecule) necessary to achieve an intended result e.g, to produce an intended immunological, pharmacological, therapeutic and/or protective result (e.g, that amount of VLPs , virions, or viral vectors sufficient to induce a measurable immune response, to prevent a particular disease condition, to reduce the severity of and/or ameliorate the disease condition or at least one symptom and/or condition associated therewith).

A “subject” or “patient,” as used therein, may be a human or non-human mammal. Non-human mammals include, for example, livestock and pets, such as ovine, bovine, porcine, canine, feline and murine mammals. Preferably, the subject is human. In some embodiments, the subject is a domestic pet or livestock. In some embodiments, the subject is a cat. In some embodiments, the subject is a dog. In some other embodiments, the subject is a ferret.

"Titers" are numerical measures of the concentration of a virus or viral vector compared to a reference sample, where the concentration is determined either by the activity of the virus, or by measuring the number of viruses in a unit volume of buffer. The titer of viral stocks are determined, e.g., by measuring the infectivity of a solution or solutions (typically serial dilutions) of the viruses, e.g., on HeLa cells using the soft agar method (see, Graham & Van Der eb (1973) Virology 52:456-467) or by monitoring resistance conferred to cells, e.g., G418 resistance encoded by the virus or vector, or by quantitating the viruses by UV spectrophotometry (see, Chardonnet & Dales (1970) Virology 40:462-477).

“Vaccination” refers to the process of inoculating a subject with an antigen to elicit an immune response in the subject, that helps to prevent or treat the disease or disorder the antigen is connected with. The term “immunization” is used interchangeably herein with vaccination.

A “vector” is a composition of matter which comprises a nucleic acid and which can be used to deliver the nucleic acid to the interior of a cell. Numerous vectors are known in the art including, but not limited to, linear polynucleotides, polynucleotides associated with ionic or amphiphilic compounds, plasmids, and viruses. In the present disclosure, the term “vector” includes an autonomously replicating virus.

Ranges: throughout this disclosure, various aspects of the invention can be presented in a range format. It should be understood that the description in range format is merely for convenience and brevity and should not be construed as an inflexible limitation on the scope of the invention. Accordingly, the description of a range should be considered to have specifically disclosed all the possible subranges as well as individual numerical values within that range. For example, description of a range such as from 1 to 6 should be considered to have specifically disclosed subranges such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6 etc., as well as individual numbers within that range, for example, 1, 2, 2.7, 3, 4, 5, 5.3, and 6. This applies regardless of the breadth of the range.

Description

The present invention relates to compositions and methods for generating vaccines against a SARS-CoV-2 virus. The SARS-CoV-2 virus is also referred to herein as 2019- nCoV or 2019 Novel Coronavirus.

Described herein is a vaccine against the SARS-CoV-2 virus that uses a rabies virus-based vector that has proven to be an efficient vector against emerging and re- emerging infectious diseases. It was previously demonstrated that inactivated rabies virus particles containing MERS-CoV spike SI protein induce potent immune responses against MERS-CoV and RABV and provide protection in animal systems.

The 2019-nCoV vaccine described herein has the following advantages:

• The construct is based on a currently available rabies vaccine product, and therefore will facilitate entry of a vaccine into a clinical phase one study to be prepared within a short time period. Bharat Biotech Ltd (BBIL) produce currently 20 million doses of the RABV vaccine a year.

• The construct can be rapidly scaled, as needed, for additional clinical trials and commercial manufacture.

• The construct can be manufactured at low cost-of-goods. Rabies vaccines have been commercially produced for decades, costs are well known and are inexpensive. The present vaccine uses the same manufacturing process as the current human rabies vaccine. When vaccinating millions of people in resource-limited areas, a low-cost vaccine is a significant advantage

• The vaccine should be safe for all population groups. In some embodiments, the vaccine is based on the killed rabies vaccine backbone since the rabies vaccine has decades of safe use across diverse populations.

• Proof of concept has been demonstrated by protecting in animal models based on challenge studies with the related MERS-CoV in two mouse models and alpacas (camelid).

• Long-term protection is expected since the RABV vaccine often provides life-long protection.

• The vaccine can be produced by an experienced commercial-scale manufacturing partner, Bharat Biotech, who has successfully met WHO pre-qualification standards for other vaccines, and can move quickly into clinical trials and commercial production. Bharat Biotech meets the FDA, EMA, and WHO PQ standards for cGMP.

• Utilises a unique polysaccharide adjuvant, Advax-SM, that has already been extensively tested in human clinical trials, being shown to enhance both humoral and cellular immunity. Most notably, addition of Advax-SM to prototype cGMP whole cell and recombinant spike protein SARS vaccines, not only enhanced neutralising antibody responses and prevented lung viral replication but also completely prevented vaccine- enhanced eosinophilic lung pathology in response to SARS virus exposure.

• Both the RABV vector and the utilized adjuvant can be stabilized and stored at room temperature.

Constructs

In one aspect, the present invention includes an isolated nucleic acid encoding a recombinant virus comprising a SARS-CoV-2 spike protein (S) or a portion thereof. In some embodiments, the virus is a rhabdovirus. In some embodiments, the virus is a rabies virus, a vesicular stomatitis virus (VSV), or a measles virus. In a particular embodiment, the virus is a rabies virus. The nucleic acid can comprises sequences that are codon-optimized for expression in a cell (e.g., a mammalian cell, a human cell).

In one embodiment, the SARS-CoV-2 spike protein (S) or the portion thereof comprises the amino acid sequence as set forth in SEQ ID NO: 28:

MF VFLVLLPL V S SQC VNLTTRT QLPP AYTN SFTRGVYYPDKVFRS S VLHSTQDLF LPFF SNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYF ASTEKSNIIRGWIF GTTLD SKTQ SLLIVNNATNVVIK V CEF QF CNDPFLGVYYFIKNNKS WMESEFRVY S S ANN CTFEYVSQPFLMDLEGKQGNFKNLREF VFKNIDGYFKIY SKHTPINLVRDLPQGF S ALEPL VDLPIGINITRF QTLL ALHRS YLTPGD S S SGWT AGAAAYYV GYLQPRTFLL KYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITN LCPF GEVFNATRF AS VY AWNRKRISNC VAD Y S VL YN S ASF STFKC Y GV SPTKLN DLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDS K V GGNYN YL YRLFRK SNLKPFERDI S TEI Y Q AGS TPCN GVEGFNC YFPLQ S Y GF Q PTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVL TESNKKFLPF QQF GRDI ADTTD AVRDPQTLEILDITPC SF GGV S VITPGTNTSNQ VA VL Y QD VNCTEVP VAIH ADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNN S YECD IPIGAGICASYQTQTNSPR.

In another embodiment, the SARS-CoV-2 spike protein (S) or the portion thereof comprises the amino acid sequence as set forth in SEQ ID NO: 29:

MF VFLVLLPL V S SQC VNLTTRT QLPP AYTN SFTRGVYYPDKVFRS S VLHSTQDLF LPFF SNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYF ASTEKSNIIRGWIF GTTLD SKTQ SLLIVNNATNVVIK V CEF QF CNDPFLGVYYHKNNKS WMESEFRVY S S ANN CTFEYVSQPFLMDLEGKQGNFKNLREF VFKNIDGYFKIY SKHTPINLVRDLPQGF S ALEPL VDLPIGINITRF QTLL ALHRS YLTPGD S S SGWT AGAAAYYV GYLQPRTFLL KYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITN LCPF GEVFNATRF AS VY AWNRKRISNC VAD Y S VL YN S ASF STFKC Y GV SPTKLN DLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDS K V GGNYNYL YRLFRK SNLKPFERDI S TEI Y Q AGS TPCN GVEGFNC YFPLQ SY GF Q PTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVL TESNKKFLPF QQF GRDIADTTD AVRDPQTLEILDITPC SF GGV S VITPGTNTSNQ VA VL Y QD VNCTEVP VAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNN S YECD IPIGAGIC AS Y QTQTN SPRRARS VASQ SIIA YTMSLGAEN S VAY SNN SIAIPTNFTIS VTTEILP V SMTKT S VDCTMYICGD STEC SNLLLQ Y GSF CTQLNRALTGI AVEQDK

NT QEVF AQ VKQI YKTPPIKDF GGFNF S QILPDP SKP SKRSFIEDLLFNK VTL AD AGF

IKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFG

AGA ALQIPF AMQM A YRFN GIGVT QN VL YEN QKLI AN QFN S AIGKIQD SL S S T A S A

LGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITG

RLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFP

Q S APHGVVFLHVT YVP AQEKNFTT AP AICHDGKAHFPREGVF V SNGTHWF VT QR

NFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPD

VDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWL

GFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT.

In one embodiment, the SARS-CoV-2 spike protein (S) or the portion thereof comprises the amino acid sequence as set forth in SEQ ID NO: 30:

MF VFLVLLPL V S SQC VNLTTRT QLPP AYTN SFTRGVYYPDKVFRS S VLHSTQDLF LPFF SNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYF ASTEKSNIIRGWIF GTTLD SKTQ SLLIVNNATNVVIK V CEF QF CNDPFLGVYYHKNNKS WMESEFRVY S S ANN CTFEYVSQPFLMDLEGKQGNFKNLREF VFKNIDGYFKIY SKHTPINLVRDLPQGF S ALEPL VDLPIGINITRF QTLL ALHRS YLTPGD S S SGWT AGAAAYYV GYLQPRTFLL KYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITN LCPF GEVFNATRF AS VY AWNRKRISNC VAD Y S VL YN S ASF STFKC Y GV SPTKLN DLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDS K V GGNYN YL YRLFRK SNLKPFERDI S TEI Y Q AGS TPCN GVEGFNC YFPLQ S Y GF Q PTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVL TESNKKFLPF QQF GRDI ADTTD AVRDPQTLEILDITPC SF GGV S VITPGTNTSNQ VA VL Y QD VNCTEVP VAIH ADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNN S YECD IPIGAGICASYQTQTNSPRSVGDEAEDFVEVHLPDVHNQVSGVDLGLPNWGKYV LLSAGALTALMLIIFLMTCCRRVNRSEPTQHNLRGTGREVSVTPQSGKIISSWESH KSGGETRL.

In another embodiment, the SARS-CoV-2 spike protein (S) or the portion thereof comprises the amino acid sequence as set forth in SEQ ID NO: 31 :

MF VFLVLLPL V S SQC VNLTTRT QLPP AYTN SFTRGVYYPDKVFRS S VLHSTQDLF LPFF SNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYF ASTEKSNIIRGWIF GTTLD SKTQSLLIVNNATNVVIKVCEF QF CNDPFLGVYYHKNNKSWMESEFRVY S S ANN CTFEYVSQPFLMDLEGKQGNFKNLREF VFKNIDGYFKIY SKHTPINLVRDLPQGF S ALEPL VDLPIGINITRF QTLL ALHRS YLTPGD S S SGWT AGAAAYYV GYLQPRTFLL KYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITN LCPF GEVFNATRF AS VY AWNRKRISNC VAD Y S VL YN S ASF STFKC Y GV SPTKLN DLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDS K V GGNYN YL YRLFRK SNLKPFERDI S TEI Y Q AGS TPCN GVEGFNC YFPLQ S Y GF Q PTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVL TESNKKFLPF QQF GRDI ADTTD AVRDPQTLEILDITPC SF GGV S VITPGTNTSNQ VA VL Y QD VNCTEVP VAIH ADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNN S YECD IPIGAGICASYQTQTNSPR.

In another embodiment, an N protein (N) or the portion thereof is provided, comprising the amino acid sequence as set forth in SEQ ID NO: 32: MATLLRSLALFKRNKDKPPITSGSGGAIRGIKHIIIVPIPGDSSITTRSRLLDRLVRLI GNPD VSGPKLT GALIGIL SLF VESPGQLIQRITDDPD V SIRLLE VVQ SDQ SQ SGLTF ASRGTNMEDEADQYF SHDDPIS SDQSRF GWF GNKEISDIEVQDPEGFNMILGTIL A QIWVLL AK VT APDT AAD SELRRWIK YTQQRRVVGEFRLERKWLD VVRNRIAE DLSLRRFMVALILDIKRTPGNKPRIAEMICDIDTYIVEAGLASFILTIKFGIETMYPA LGLHEF AGEL STLESLMNL Y QQMGET AP YMVILEN SIQNKF S AGS YPLLW S YAM GV GVELEN SMGGLNF GRS YFDP AYFRLGQEMVRRS AGK V S STL ASELGIT AED A RLVSEIAMHTTEDKISRAVGPRQAQVSFLHGDQSENELPRLGGKEDRRVKQSRGE ARESYRETGPSRASDARAAHLPTGTPLDIDTATESSQDPQDSRRSADALLRLQAM AGISEEQGSDTDTPIVYNDRNLLD.

In another embodiment, the SARS-CoV-2 spike protein (S) or the portion thereof is a variant spike polypeptide comprising one or more alterations ( e.g substitution(s), insertion(s), deletion(s), addition(s), modification(s)) in its amino acid sequence relative to the amino acid sequence set forth as SEQ ID NO: 28, 29, 30, or 31.

In other embodiments, the SARS-CoV-2 spike protein (S) or the portion thereof is a variant spike polypeptide comprising, relative to the amino acid sequence set forth as SEQ ID NO: 28, 29, 30, or 31, at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16,

17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30 or more alterations.

In one embodiment, the SARS-CoV-2 spike protein (S) or the portion thereof is a variant spike polypeptide comprising at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, but not 100%, sequence identity to the amino acid sequence set forth as SEQ ID NO: 28, 29, 30, or 31. In another embodiment, the N protein (N) or the portion thereof is a variant N polypeptide comprising one or more alterations ( e.g substitution(s), insertion(s), deletion(s), addition(s), modification(s)) in its amino acid sequence relative to the amino acid sequence set forth as SEQ ID NO: 32.

In other embodiments, the N protein (N) or the portion thereof is a variant N polypeptide comprising, relative to the amino acid sequence set forth as SEQ ID NO: 32, at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25,

26, 27, 28, 29, 30 or more alterations.

In one embodiment, the N protein (N) or the portion thereof is a variant N polypeptide comprising at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, but not 100%, sequence identity to the amino acid sequence set forth as SEQ ID NO: 32.

In some embodiments, the recombinant virus expresses a full-length SARS-CoV- 2 spike protein (S). In some other embodiments, the recombinant virus expresses a portion of the SARS-CoV-2 spike protein (S). In one embodiment, the portion of the SARS-CoV-2 spike protein (S) is a receptor binding site of the SARS-CoV-2 spike protein (S). In another embodiment, the portion of the SARS-CoV-2 spike protein (S) is the SI domain. In another embodiment, the portion of the SARS-CoV-2 spike protein (S) is the N-terminal 750 amino acids of the SARS-CoV-2 spike protein (S).

In some embodiments, the SARS-CoV-2 spike protein (S) or portion thereof is fused to a glycoprotein (G) or a portion thereof. In some embodiments, the glycoprotein (G) comprises a mutation substituting arginine with glutamic acid at position 333. In some embodiments, the portion of glycoprotein (G) comprises an ectodomain, a cytoplasmic domain, and a transmembrane domain. In other embodiments, the portion of the glycoprotein (G) comprises 1 to about 100 amino acids of the ectodomain or a trimerization domain. In some embodiments, the portion of the glycoprotein (G) comprises 31 amino acids of the ectodomain. In some embodiments, the glycoprotein (G) comprises 31 amino acids of the ectodomain and the full-length cytoplasmic domain.

In some embodiments, the sequence encoding the SARS-CoV-2 spike protein (S) or portion thereof is codon-optimized for expression in a cell. In some embodiments, the sequence encoding the the SARS-CoV-2 spike protein (S) or portion thereof fused to a glycoprotein (G) or portion thereof is codon-optimized for expression in a cell. In some embodiments, the nucleic acid comprises a sequence encoding at least a portion of the genome of the virus. In some embodiments, the isolated nucleic acid comprises the full-length genome.

In one embodiment, the nucleic acid comprises (a) a sequence encoding at least a portion of the genome of a vesicular stomatitis virus (VSV), and (b) a sequence encoding a protein comprising a SARS-CoV-2 spike protein (S) or a portion thereof. In some embodiments, the protein comprising a SARS-CoV-2 spike protein (S) or a portion thereof is a fusion protein comprising a glycoprotein (G) or a portion thereof and a SARS-CoV-2 spike protein (S) or a portion thereof. In some embodiments, the fusion protein comprises a glycoprotein (G) or portion thereof fused to the SI domain of a SARS-CoV-2 spike protein (S).

In another embodiment, the nucleic acid comprises the sequence of SEQ ID NO:

1, shown below:

CTGACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCG

CAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCT

TCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGG

GGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAA

CTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTT

TCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAA

CTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATT

TTGCCGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAA

CGCGAATTTTAACAAAATATTAACGCTTACAATTTCCATTCGCCATTCAGGCT

GCGCAACTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAG

CTGGCGAA AGGGGGAT GT GCTGC AAGGCGATT AAGTT GGGT AACGCC AGGGT

TTTCCCAGTCACGACGTTGTAAAACGACGGCCAGTGAGcgcgccCTAGTTATTAA

TAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGT

TACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGC

CCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTT

CC ATT GACGT C AAT GGGT GGAGT ATTT ACGGT AAACTGCCC ACTT GGC AGT AC

ATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAA

ATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTT

GGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGG

C AGT AC AT C A AT GGGC GT GG AT AGC GGTTT GACTC AC GGGGATTTCC A AGT C

TCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGAC TTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGC

GTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCTGGCTAACTAGAGAACC

CACTGCTTACTGGCTTATCGAAATTAATACGACTCACTATAGGGAGACCCAA

GCTGGCTAGGGTCTTCGTCTGATGAGTCCGTGAGGACGAAACCCGGCGTACC

GGGT C ACGAAGAC AAAC AAACC ATT ATT ATC ATT AAAAGGCTC AGGAGAAAC

TTTAACAGTAATCAAAATGTCTGTTACAGTCAAGAGAATCATTGACAACACA

GTCATAGTTCCAAAACTTCCTGCAAATGAGGATCCAGTGGAATACCCGGCAG

ATTACTTCAGAAAATCAAAGGAGATTCCTCTTTACATCAATACTACAAAAAGT

TTGTCAGATCTAAGAGGATATGTCTACCAAGGCCTCAAATCCGGAAATGTAT

C AAT CAT AC AT GT C AAC AGCT ACTT GT AT GGAGC ATT AAAGGAC ATCCGGGG

T AAGTT GGAT AAAGATT GGT C AAGTTTCGGAAT AAAC ATCGGGAAAGC AGGG

GATACAATCGGAATATTTGACCTTGTATCCTTGAAAGCCCTGGACGGCGTACT

TCCAGATGGAGTATCGGATGCTTCCAGAACCAGCGCAGATGACAAATGGTTG

CCTTTGTATCTACTTGGCTTATACAGAGTGGGCAGAACACAAATGCCTGAATA

C AGA A A A A AGCTC AT GGAT GGGCTGAC A A AT C A AT GCA A A AT GATC A AT G A

ACAGTTTGAACCTCTTGTGCCAGAAGGTCGTGACATTTTTGATGTGTGGGGAA

ATGACAGTAATTACACAAAAATTGTCGCTGCAGTGGACATGTTCTTCCACATG

TTCAAAAAACATGAATGTGCCTCGTTCAGATACGGAACTATTGTTTCCAGATT

CAAAGATTGTGCTGCATTGGCAACATTTGGACACCTCTGCAAAATAACCGGA

ATGTCTACAGAAGATGTAACGACCTGGATCTTGAACCGAGAAGTTGCAGATG

AAATGGTCCAAATGATGCTTCCAGGCCAAGAAATTGACAAGGCCGATTCATA

CATGCCTTATTTGATCGACTTTGGATTGTCTTCTAAGTCTCCATATTCTTCCGT

CAAAAACCCTGCCTTCCACTTCTGGGGGCAATTGACAGCTCTTCTGCTCAGAT

CCACCAGAGCAAGGAATGCCCGACAGCCTGATGACATTGAGTATACATCTCT

TACTACAGCAGGTTTGTTGTACGCTTATGCAGTAGGATCCTCTGCCGACTTGG

CACAACAGTTTTGTGTTGGAGATAACAAATACACTCCAGATGATAGTACCGG

AGGATTGACGACTAATGCACCGCCACAAGGCAGAGATGTGGTCGAATGGCTC

GGATGGTTTGAAGATCAAAACAGAAAACCGACTCCTGATATGATGCAGTATG

CGA A A AGAGC AGT CAT GT C AC T GC A AGGCC T A AGAGAGA AGAC A ATT GGC A

AGTATGCTAAGTCAGAATTTGACAAATGACCCTATAATTCTCAGATCACCTAT

TATATATTATGCTACATATGAAAAAAACTAACAGATATCATGGATAATCTCAC

AAAAGTTCGTGAGTATCTCAAGTCCTATTCTCGTCTGGATCAGGCGGTAGGAG

AG AT AG AT GAGATCGAAGC AC AACGAGCTGAAAAGTCC AATT ATGAGTTGTT

CCAAGAGGATGGAGTGGAAGAGCATACTAAGCCCTCTTATTTTCAGGCAGCA GAT GATTCTGAC AC AGAATCTGAACC AGAAATTGAAGAC AAT C AAGGTTT GT

ATGCACCAGATCCAGAAGCTGAGCAAGTTGAAGGCTTTATACAGGGGCCTTT

AG AT GAC T AT GC AGAT GAGGA AGT GGAT GTTGT ATTT ACTT C GGACTGGA A A

CAGCCTGAGCTTGAATCTGACGAGCATGGAAAGACCTTACGGTTGACATCGC

C AGAGGGTTT AAGTGGAGAGC AGAAATCCC AGT GGCTTTCGACGATT AAAGC

AGTCGT GC AAAGT GCC AAAT ACTGGAATCTGGC AGAGTGC AC ATTT GAAGC A

T C GGG AG A AGGGGT C ATT AT G A AGG AGC GC C AG AT A AC TC C GGAT GT AT AT A

AGGTCACTCCAGTGATGAACACACATCCGTCCCAATCAGAAGCAGTATCAGA

TGTTTGGTCTCTCTCAAAGACATCCATGACTTTCCAACCCAAGAAAGCAAGTC

TTCAGCCTCTCACCATATCCTTGGATGAATTGTTCTCATCTAGAGGAGAGTTC

ATCTCTGTCGGAGGTGACGGACGAATGTCTCATAAAGAGGCCATCCTGCTCG

GCCTGAGATACAAAAAGTTGTACAATCAGGCGAGAGTCAAATATTCTCTGTA

GACT AT GAAAAAAAGT AAC AGAT ATC ACGATCT AAGTGTT ATCCC AATCC AT

TC AT C AT G AGTT C C TT A A AG A AG AT TC TC GGT C T G A AGGGG A A AGGT A AG A A

ATCTAAGAAATTAGGGATCGCACCACCCCCTTATGAAGAGGACACTAGCATG

GAGTATGCTCCGAGCGCTCCAATTGACAAATCCTATTTTGGAGTTGACGAGAT

GGACACCTATGATCCGAATCAATTAAGATATGAGAAATTCTTCTTTACAGTGA

AAATGACGGTTAGATCTAATCGTCCGTTCAGAACATACTCAGATGTGGCAGC

CGCTGT ATCCC ATT GGG AT C AC ATGT AC ATCGGAAT GGC AGGGAAACGTCCC

TTCTACAAAATCTTGGCTTTTTTGGGTTCTTCTAATCTAAAGGCCACTCCAGCG

GT ATT GGC AGAT C A AGGT C AACC AGAGT AT C AC ACTC ACTGCGAAGGC AGGG

CTTATTTGCCACATAGGATGGGGAAGACCCCTCCCATGCTCAATGTACCAGA

GC ACTT C AG A AG ACC ATT C AAT AT AGGTCTTT AC A AGGGAACGATT GAGCTC

ACAATGACCATCTACGATGATGAGTCACTGGAAGCAGCTCCTATGATCTGGG

AT C ATTT C AATTCTTCC A AATTTTCTGATTT C AGAGAGAAGGCCTT AATGTTT G

GCCTGATTGTCGAGAAAAAGGCATCTGGAGCGTGGGTCCTGGATTCTATCAG

CCACTTCAAATGAGCTAGTCTAACTTCTAGCTTCTGAACAATCCCCGGTTTAC

TCAGTCTCTCCTAATTCCAGCCTCTCGAACAACTAATATCCTGTCTTTTCTATC

CCTATGAAAAAAACTAACAGAGATCGATCTGTTTACGCGTCACTATGAAGTG

CCTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGT

TTTTCCACAC AACC AAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACC ATT

ATTGCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCC

AT AC AAGT C AAAAT GCCC AAGAGT C AC AAGGCT ATTC AAGC AGACGGTTGGA

TGTGTCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCG AAGTATATAACACAGTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAA

GGAAAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCT

CCTCAAAGTTGTGGATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCC

AGGTGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGA

TTC AC AGTT CAT C AACGGAAAAT GC AGC AATT AC AT ATGCCCC ACTGTCC AT A

ACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAAC

CTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCT

GGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATGAAACTGGA

GGC AAGGCCTGC AAAAT GC AAT ACTGC AAGC ATT GGGGAGT C AGACTCCC AT

CAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTC

CCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGA

TGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAG

AAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAG

CTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATG

GTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCA

AT C C T C T C A AG A AT GGT C GG A AT GAT C AGT GG A AC T AC C AC AG A A AGGG A AC

T GT GGGAT GAC T GGGC ACC AT AT GA AGACGT GGA A ATT GGACC C A AT GGAGT

TCTGAGG ACC AGTT C AGGAT AT AAGTTTCCTTT AT AC AT GATTGGAC AT GGT A

TGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCT

CACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGG

TGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGT

AGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGA

CTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACC

AAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAA

CTCAAATCCTGCTAGGTATGAAAAAAACTAACaGATATCACGCTCGAGCGTAC

GCCACCATGTTCGTGTTTCTGGTGCTGCTGCCTCTGGTGAGCTCCCAGTGCGT

GAACCTGACCACAAGGACCCAGCTGCCCCCTGCCTATACCAATTCCTTCACAC

GGGGCGTGTACTATCCCGACAAGGTGTTCCGGAGCAGCGTGCTGCACTCCAC

ACAGGATCTGTTTCTGCCTTTCTTTTCTAACGTGACCTGGTTCCACGCCATCCA

CGTGAGCGGCACCAATGGCACAAAGCGGTTCGACAATCCAGTGCTGCCCTTT

AACGATGGCGTGTACTTCGCCTCCACCGAGAAGTCTAACATCATCAGAGGCT

GGATCTTTGGCACCACACTGGACAGCAAGACACAGTCCCTGCTGATCGTGAA

CAATGCCACCAACGTGGTCATCAAGGTGTGCGAGTTCCAGTTTTGTAATGATC

C ATTCCTGGGCGT GT ACT AT C AC AAGAAC AAT AAGTCTTGGAT GGAGAGCGA GTTTCGCGTGTATTCCTCTGCCAACAATTGCACATTTGAGTACGTGTCCCAGC

CCTTCCTGATGGACCTGGAGGGCAAGCAGGGCAATTTCAAGAACCTGAGGGA

GTTCGTGTTTAAGAATATCGATGGCTACTTCAAAATCTACTCCAAGCACACCC

CAATCAACCTGGTGCGCGACCTGCCACAGGGCTTCTCTGCCCTGGAGCCACTG

GTGGATCTGCCCATCGGCATCAACATCACCCGGTTTCAGACACTGCTGGCCCT

GCACAGAAGCTACCTGACACCAGGCGACAGCTCCTCTGGATGGACCGCAGGA

GCAGCAGCCTACTATGTGGGCTATCTGCAGCCCAGGACCTTCCTGCTGAAGTA

CAACGAGAATGGCACCATCACAGACGCCGTGGATTGCGCCCTGGATCCCCTG

TCTGAGACCAAGTGTACACTGAAGAGCTTTACCGTGGAGAAGGGCATCTATC

AGACAAGCAATTTCAGGGTGCAGCCTACCGAGTCCATCGTGCGCTTTCCCAAT

ATCACAAACCTGTGCCCTTTTGGCGAGGTGTTCAACGCAACCCGCTTCGCCAG

CGTGTACGCCTGGAATAGGAAGCGCATCTCCAACTGCGTGGCCGACTATTCT

GTGCTGTACAACAGCGCCTCCTTCTCTACCTTTAAGTGCTATGGCGTGAGCCC

CACAAAGCTGAATGACCTGTGCTTTACCAACGTGTACGCCGATTCCTTCGTGA

TCAGGGGCGACGAGGTGCGCCAGATCGCACCAGGACAGACAGGCAAGATCG

CAGACTACAATTATAAGCTGCCTGACGATTTCACCGGCTGCGTGATCGCCTGG

AACTCTAACAATCTGGATAGCAAAGTGGGCGGCAACTACAATTATCTGTACC

GGCTGTTTAGAAAGTCTAATCTGAAGCCATTCGAGAGGGACATCTCCACAGA

AATCTACCAGGCCGGCTCTACCCCCTGCAATGGCGTGGAGGGCTTTAACTGTT

ATTTCCCTCTGCAGAGCTACGGCTTCCAGCCAACAAACGGCGTGGGCTATCA

GCCCTACCGCGTGGTGGTGCTGTCTTTTGAGCTGCTGCACGCACCTGCAACAG

T GTGCGGACC AA AGAAGAGC ACC AATCTGGT GAAGAAC AAGT GCGT GAACTT

CAACTTCAACGGACTGACCGGAACAGGCGTGCTGACCGAGTCCAACAAGAAG

TTCCTGCCTTTTCAGCAGTTCGGCAGGGACATCGCAGATACCACAGACGCCGT

GCGCGACCCTCAGACCCTGGAGATCCTGGACATCACACCATGCTCCTTCGGC

GGCGTGTCTGTGATCACACCAGGCACCAATACAAGCAACCAGGTGGCCGTGC

TGTATCAGGACGTGAATTGTACCGAGGTGCCAGTGGCAATCCACGCAGATCA

GCTGACCCCTACATGGCGGGTGTACTCTACCGGCAGCAACGTGTTCCAGACA

AGAGCCGGATGCCTGATCGGAGCAGAGCACGTGAACAATAGCTATGAGTGCG

ACATCCCTATCGGCGCCGGCATCTGTGCCTCCTACCAGACCCAGACAAACTCC

CCAAGGTCTGTGGGCGATACAGGCCTGTCCAAGAATCCAATCGAGCTGGTAG

AGGGCTGGTTCAGCAGTTGGAAAAGCTCCATCGCCTCCTTTTTCTTTATCATC

GGCCTGATCATCGGACTGTTCCTGGTGCTCCGCGTGGGTATCCACCTGTGCAT

CAAGCTGAAGCACACCAAGAAAAGACAGATTTATACAGACATCGAGATGAA CCGCCTGGGAAAGTGAGCTAGCCAGATTCTTCATGTTTGGACCAAATCAACTT

GTGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATG

AAAAAAACTAACAGCAATCATGGAAGTCCACGATTTTGAGACCGACGAGTTC

AATGATTTCAATGAAGATGACTATGCCACAAGAGAATTCCTGAATCCCGATG

AGCGCATGACGTACTTGAATCATGCTGATTACAATTTGAATTCTCCTCTAATT

AGTGATGATATTGACAATTTGATCAGGAAATTCAATTCTCTTCCGATTCCCTC

GATGTGGGATAGTAAGAACTGGGATGGAGTTCTTGAGATGTTAACATCATGT

C A AGC C A ATCC C ATCTC A AC ATCTC AGAT GC AT A A AT GGAT GGGA AGTT GGT

TAATGTCTGATAATCATGATGCCAGTCAAGGGTATAGTTTTTTACATGAAGTG

GACAAAGAGGCAGAAATAACATTTGACGTGGTGGAGACCTTCATCCGCGGCT

GGGGC AAC AAACC AATTGAAT AC ATC AAAAAGGAAAGATGGACTGACTC ATT

CAAAATTCTCGCTTATTTGTGTCAAAAGTTTTTGGACTTACACAAGTTGACAT

TAATCTTAAATGCTGTCTCTGAGGTGGAATTGCTCAACTTGGCGAGGACTTTC

AAAGGCAAAGTCAGAAGAAGTTCTCATGGAACGAACATATGCAGGATTAGG

GTTCCCAGCTTGGGTCCTACTTTTATTTCAGAAGGATGGGCTTACTTCAAGAA

ACTTGATATTCTAATGGACCGAAACTTTCTGTTAATGGTCAAAGATGTGATTA

T AGGGAGGAT GCA A AC GGT GC T ATC CAT GGT AT GT AG A AT AGAC A AC CTGTT

CTCAGAGCAAGACATCTTCTCCCTTCTAAATATCTACAGAATTGGAGATAAAA

TTGTGGAGAGGCAGGGAAATTTTTCTTATGACTTGATTAAAATGGTGGAACCG

ATATGCAACTTGAAGCTGATGAAATTAGCAAGAGAATCAAGGCCTTTAGTCC

C AC AATTCCCTC ATTTTGAAAATC AT AT C AAGACTTCTGTT GAT GAAGGGGC A

A A A AT T G AC C G AGGT AT A AG ATT C C T C C AT GAT C AG AT A AT G AGT GT G A A A A

CAGTGGATCTCACACTGGTGATTTATGGATCGTTCAGACATTGGGGTCATCCT

TTTATAGATTATTACACTGGACTAGAAAAATTACATTCCCAAGTAACCATGAA

GAAAGATATTGATGTGTCATATGCAAAAGCACTTGCAAGTGATTTAGCTCGG

ATTGTTCTATTTCAACAGTTCAATGATCATAAAAAGTGGTTCGTGAATGGAGA

CTTGCTCCCTCATGATCATCCCTTTAAAAGTCATGTTAAAGAAAATACATGGC

CCACAGCTGCTCAAGTTCAAGATTTTGGAGATAAATGGCATGAACTTCCGCTG

ATTAAATGTTTTGAAATACCCGACTTACTAGACCCATCGATAATATACTCTGA

C A A A AGTC ATT C A AT GA AT AGGT C AGAGGT GTTGA A AC AT GTCCGA AT GA AT

CCGAACACTCCTATCCCTAGTAAAAAGGTGTTGCAGACTATGTTGGACACAA

AGGCTACCAATTGGAAAGAATTTCTTAAAGAGATTGATGAGAAGGGCTTAGA

TGATGAT GATCT AATT ATT GGTCTT AAAGGAAAGGAGAGGGAACTGAAGTTG

GCAGGTAGATTTTTCTCCCTAATGTCTTGGAAATTGCGAGAATACTTTGTAAT TACCGAATATTTGATAAAGACTCATTTCGTCCCTATGTTTAAAGGCCTGACAA

TGGCGGACGATCTAACTGCAGTCATTAAAAAGATGTTAGATTCCTCATCCGGC

C AAGGATT GAAGT CAT ATGAGGC AATTT GC AT AGCC AAT C AC ATT GATT ACG

AAAAATGGAATAACCACCAAAGGAAGTTATCAAACGGCCCAGTGTTCCGAGT

TATGGGCCAGTTCTTAGGTTATCCATCCTTAATCGAGAGAACTCATGAATTTT

TT GAGAAAAGTCTT AT AT ACT AC AAT GGAAGACC AGACTTGAT GCGT GTT C A

CAACAACACACTGATCAATTCAACCTCCCAACGAGTTTGTTGGCAAGGACAA

G AGGGT GG AC T GG A AGGT C T AC GGC A A A A AGG AT GG AC T ATC C T C A AT C T AC

TGGTTATTCAAAGAGAGGCTAAAATCAGAAACACTGCTGTCAAAGTCTTGGC

ACAAGGTGATAATCAAGTTATTTGCACACAGTATAAAACGAAGAAATCGAGA

AACGTT GT AGAATT AC AGGGT GCTCTC AAT C AAAT GGTTTCT AAT AATGAGAA

AATT AT GACTGC AATC AA AAT AGGGAC AGGGAAGTT AGGACTTTT GAT AAAT

GACGATGAGACT AT GC AATCTGC AGATT ACTTGAATT AT GGAAAAAT ACCGA

TTTTCCGTGGAGTGATTAGAGGGTTAGAGACCAAGAGATGGTCACGAGTGAC

TTGTGTCACCAATGACCAAATACCCACTTGTGCTAATATAATGAGCTCAGTTT

CCACAAATGCTCTCACCGTAGCTCATTTTGCTGAGAACCCAATCAATGCCATG

ATACAGTACAATTATTTTGGGACATTTGCTAGACTCTTGTTGATGATGCATGA

TCCTGCTCTTCGTCAATCATTGTATGAAGTTCAAGATAAGATACCGGGCTTGC

ACAGTTCTACTTTCAAATACGCCATGTTGTATTTGGACCCTTCCATTGGAGGA

GTGTCGGGCATGTCTTTGTCCAGGTTTTTGATTAGAGCCTTCCCAGATCCCGT

AACAGAAAGTCTCTCATTCTGGAGATTCATCCATGTACATGCTCGAAGTGAGC

ATCTGAAGGAGAT GAGT GC AGT ATTTGGAAACCCCGAGAT AGCC AAGTTTCG

AATAACTCACATAGACAAGCTAGTAGAAGATCCAACCTCTCTGAACATCGCT

ATGGGAATGAGTCCAGCGAACTTGTTAAAGACTGAGGTTAAAAAATGCTTAA

TCGAATCAAGACAAACCATCAGGAACCAGGTGATTAAGGATGCAACCATATA

TTTGTATCATGAAGAGGATCGGCTCAGAAGTTTCTTATGGTCAATAAATCCTC

TGTTCCCTAGATTTTTAAGTGAATTCAAATCAGGCACTTTTTTGGGAGTCGCA

GACGGGCTCATCAGTCTATTTCAAAATTCTCGTACTATTCGGAACTCCTTTAA

G A A A A AGT ATC AT AGGG A ATT GG AT GAT T T GAT TGT G AGG AGT G AGGT ATC C

TCTTTGAC AC ATTT AGGGAAACTTC ATTTGAGAAGGGGAT CAT GT AAAAT GT G

GACATGTTCAGCTACTCATGCTGACACATTAAGATACAAATCCTGGGGCCGT

ACAGTTATTGGGACAACTGTACCCCATCCATTAGAAATGTTGGGTCCACAAC

ATCGAAAAGAGACTCCTTGTGCACCATGTAACACATCAGGGTTCAATTATGTT

TCTGTGCATTGTCCAGACGGGATCCATGACGTCTTTAGTTCACGGGGACCATT GCCTGCTTATCTAGGGTCTAAAACATCTGAATCTACATCTATTTTGCAGCCTT

GGGAAAGGGAAAGCAAAGTCCCACTGATTAAAAGAGCTACACGTCTTAGAG

ATGCTATCTCTTGGTTTGTTGAACCCGACTCTAAACTAGCAATGACTATACTT

TCTAACATCCACTCTTTAACAGGCGAAGAATGGACCAAAAGGCAGCATGGGT

TCAAAAGAACAGGGTCTGCCCTTCATAGGTTTTCGACATCTCGGATGAGCCAT

GGTGGGTTCGCATCTCAGAGCACTGCAGCATTGACCAGGTTGATGGCAACTA

CAGACACCATGAGGGATCTGGGAGATCAGAATTTCGACTTTTTATTCCAAGC

AACGTTGCTCTATGCTCAAATTACCACCACTGTTGCAAGAGACGGATGGATC

ACCAGTTGTACAGATCATTATCATATTGCCTGTAAGTCCTGTTTGAGACCCAT

AGAAGAGATCACCCTGGACTCAAGTATGGACTACACGCCCCCAGATGTATCC

CAT GT GC T G A AG AC AT GG AGG A AT GGGG A AGGT T C GT GGGG AC A AG AG AT A

AAACAGATCTATCCTTTAGAAGGGAATTGGAAGAATTTAGCACCTGCTGAGC

AATCCTATCAAGTCGGCAGATGTATAGGTTTTCTATATGGAGACTTGGCGTAT

AGAAAATCTACTCATGCCGAGGACAGTTCTCTATTTCCTCTATCTATACAAGG

TCGTATTAGAGGTCGAGGTTTCTTAAAAGGGTTGCTAGACGGATTAATGAGA

GCAAGTTGCTGCCAAGTAATACACCGGAGAAGTCTGGCTCATTTGAAGAGGC

CGGCCAACGCAGTGTACGGAGGTTTGATTTACTTGATTGATAAATTGAGTGTA

TCACCTCCATTCCTTTCTCTTACTAGATCAGGACCTATTAGAGACGAATTAGA

AACGATTCCCCACAAGATCCCAACCTCCTATCCGACAAGCAACCGTGATATG

GGGGTGATTGTCAGAAATTACTTCAAATACCAATGCCGTCTAATTGAAAAGG

GAAAATACAGATCACATTATTCACAATTATGGTTATTCTCAGATGTCTTATCC

ATAGACTTCATTGGACCATTCTCTATTTCCACCACCCTCTTGCAAATCCTATAC

AAGCCATTTTTATCTGGGAAAGATAAGAATGAGTTGAGAGAGCTGGCAAATC

TTTCTTC ATT GCT AAGAT C AGGAGAGGGGTGGGAAGAC AT AC ATGT GAAATT

CTTCACCAAGGACATATTATTGTGTCCAGAGGAAATCAGACATGCTTGCAAG

TTCGGGATTGCTAAGGATAATAATAAAGACATGAGCTATCCCCCTTGGGGAA

GGGAATCCAGAGGGACAATTACAACAATCCCTGTTTATTATACGACCACCCC

TTACCCAAAGATGCTAGAGATGCCTCCAAGAATCCAAAATCCCCTGCTGTCC

GGAATCAGGTTGGGCCAATTACCAACTGGCGCTCATTATAAAATTCGGAGTA

TATTACATGGAATGGGAATCCATTACAGGGACTTCTTGAGTTGTGGAGACGG

CTCCGGAGGGAT GACTGCTGC ATT ACT ACGAGAAAAT GT GC AT AGC AGAGGA

ATATTCAATAGTCTGTTAGAATTATCAGGGTCAGTCATGCGAGGCGCCTCTCC

TGAGCCCCCCAGTGCCCTAGAAACTTTAGGAGGAGATAAATCGAGATGTGTA

AAT GGTGAAAC AT GTT GGGAAT ATCC ATCTGACTT AT GT GACCC AAGGACTT GGGACTATTTCCTCCGACTCAAAGCAGGCTTGGGGCTTCAAATTGATTTAATT

GTAATGGATATGGAAGTTCGGGATTCTTCTACTAGCCTGAAAATTGAGACGA

ATGTTAGAAATTATGTGCACCGGATTTTGGATGAGCAAGGAGTTTTAATCTAC

A AG AC TT AT GGA AC AT AT ATTTGT GAGAGC GA A A AGA AT GC AGT A AC A AT C C

TTGGTCCCATGTTCAAGACGGTCGACTTAGTTCAAACAGAATTTAGTAGTTCT

C A A AC GT C T G A AGT AT AT AT GGT AT GT A A AGGTT T G A AG A A AT T A AT C GAT G

AACCCAATCCCGATTGGTCTTCCATCAATGAATCCTGGAAAAACCTGTACGCA

TTCCAGTCATCAGAACAGGAATTTGCCAGAGCAAAGAAGGTTAGTACATACT

TTACCTTGACAGGTATTCCCTCCCAATTCATTCCTGATCCTTTTGTAAACATTG

AGACTATGCTACAAATATTCGGAGTACCCACGGGTGTGTCTCATGCGGCTGCC

TTAAAATCATCTGATAGACCTGCAGATTTATTGACCATTAGCCTTTTTTATATG

GCGATT AT ATCGT ATT AT AAC AT C AAT CAT AT C AG AGT AGGACCGAT ACCTCC

GAACCCCCCATCAGATGGAATTGCACAAAATGTGGGGATCGCTATAACTGGT

ATAAGCTTTTGGCTGAGTTTGATGGAGAAAGACATTCCACTATATCAACAGTG

TTTAGCAGTTATCCAGCAATCATTCCCGATTAGGTGGGAGGCTGTTTCAGTAA

AAGGAGGAT AC AAGC AGAAGT GGAGT ACT AGAGGT GATGGGCTCCC AAAAG

ATACCCGAACTTCAGACTCCTTGGCCCCAATCGGGAACTGGATCAGATCTCTG

GAATTGGTCCGAAACCAAGTTCGTCTAAATCCATTCAATGAGATCTTGTTCAA

T C AGCT AT GTCGT AC AGTGGAT AAT C ATTT GAAAT GGT C AAATTT GCGA AGAA

AC AC AGGAAT GATT GAAT GGAT C AAT AGACGAATTTC AAAAGAAGACCGGT C

T AT AC T GAT GT T G A AG AGT G AC C T AC AC G AGG A A A AC TC TT GG AG AG AT T A A

AAAATCATGAGGAGACTCCAAACTTTAAGTATGAAAAAAACTTTGATCCTTA

AGACCCTCTTGTGGTTTTTATTTTTTATCTGGTTTTGTGGTCTTCGTGGGTCGG

CATGGCATCTCCACCTCCTCGCGGTCCGACCTGGGCATCCGAAGGAGGACGC

ACGTCCACTCGGATGGCTAAGGGAGAGCCAGAAAATAACTAGTGGATCCGGC

TGCTAACAAAGCCCGAAAGGAAGCTGAGTTGGCTGCTGCCACCGCTGAGCAA

TAACTAGCATAACCCCTTGGGGCCTCTAAACGGGTCTTGAGGGGTTTTTTGCT

GAAAGtCGCGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTT

ATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGC

CTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGC

CCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAA

CGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCAC

TGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAA

AGGC GGT AAT ACGGTT AT C C AC AGA AT C AGGGGAT AAC GC AGG A A AGA AC A TGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGC

TGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGC

T C AAGTC AGAGGT GGCGA AACCCGAC AGGACT AT AAAGAT ACC AGGCGTTT C

CCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGA

TACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACG

CTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGC

ACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTT

GAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTA

ACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTG

GTGGCCTAACTACGGCTACACTAGAAGGACAGTATTTGGTATCTGCGCTCTGC

TGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACA

AACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCA

GAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCT

C AGT GGA AC GA A A ACTC AC GTT A AGGGATTTT GGT CAT GAGATT AT C A A A A A

GGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAA

AGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGC

ACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGT

CGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCA

ATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACC

AGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTC

CATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTA

ATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCG

TCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTAC

ATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCG

TTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTG

CATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGA

GTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTT

GCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGT

GCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGC

TGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCA

TCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATG

CCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTT

CCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATA CAT ATTTGAAT GT ATTT AGAAAAAT AAAC AAAT AGGGGTTCCGCGC AC ATTT C CCCGAAAAGTGCCAC.

In one embodiment, the nucleic acid comprises (a) a sequence encoding at least a portion of the genome of a rabies virus and (b) a sequence encoding a protein comprising a SARS-CoV-2 spike protein (S) or a portion thereof. In some embodiments, the at least a portion of the genome of the rabies virus comprises an N gene and a P gene, and the sequence encoding the protein comprising the SARS-CoV-2 spike protein (S) or portion thereof is inserted into a position between the N gene and P gene. In some embodiments, the protein comprising a SARS-CoV-2 spike protein (S) or a portion thereof is a fusion protein comprising a glycoprotein (G) or a portion thereof and a SARS-CoV-2 spike protein (S) or a portion thereof. In some embodiments, the fusion protein comprises a glycoprotein (G) or portion thereof fused to the SI domain of a SARS-CoV-2 spike protein (S).

In another embodiment, the nucleic acid comprises the sequence of SEQ ID NO:

2, shown below:

CTGACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCG

CAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCT

TCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGG

GGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAA

CTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTT

TCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAA

CTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATT

TTGCCGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAA

CGCGAATTTTAACAAAATATTAACGCTTACAATTTCCATTCGCCATTCAGGCT

GCGCAACTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAG

CTGGCGAA AGGGGGAT GT GCTGC AAGGCGATT AAGTT GGGT AACGCC AGGGT

TTTCCCAGTCACGACGTTGTAAAACGACGGCCAGTGAGcgcgccCTAGTTATTAA

TAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGT

TACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGC

CCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTT

CC ATT GACGT C AAT GGGT GGAGT ATTT ACGGT AAACTGCCC ACTT GGC AGT AC

ATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAA

ATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTT

GGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGG C AGT AC AT C A AT GGGC GT GG AT AGC GGTTT GACTC AC GGGGATTTCC A AGT C

TCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGAC

TTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGC

GTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCTGGCTAACTAGAGAACC

CACTGCTTACTGGCTTATCGAAATTAATACGACTCACTATAGGGAGACCCAA

GCTGGCTAGATTAAGCGTCTGATGAGTCCGTGAGGACGAAACCCGGCGTACC

GGGTCACGCTTAACAACCAGATCAAAGAAAAAACAGACATTGTCAATTGCAA

AGCAAAAATGTAACACCCCTACAATGGATGCCGACAAGATTGTATTCAAAGT

CAATAATCAGGTGGTCTCTTTGAAGCCTGAGATTATCGTGGATCAATATGAGT

ACAAGTACCCTGCCATCAAAGATTTGAAAAAGCCCTGTATAACCCTAGGAAA

GGCTCCCGATTTAAATAAAGCATACAAGTCAGTTTTGTCAGGCATGAGCGCC

GCCAAACTTAATCCTGACGATGTATGTTCCTATTTGGCAGCGGCAATGCAGTT

TTTTGAGGGGACATGTCCGGAAGACTGGACCAGCTATGGAATTGTGATTGCA

CGAAAAGGAGATAAGATCACCCCAGGTTCTCTGGTGGAGATAAAACGTACTG

AT GT AGAAGGGAATT GGGCTCTGAC AGGAGGC ATGGAACTGAC AAGAGACC

CCACTGTCCCTGAGCATGCGTCCTTAGTCGGTCTTCTCTTGAGTCTGTATAGGT

T GAGC AAAAT ATCCGGGC AAAAC ACTGGT AACT AT AAGAC AAAC ATTGC AGA

CAGGATAGAGCAGATTTTTGAGACAGCCCCTTTTGTTAAAATCGTGGAACAC

CATACTCTAATGACAACTCACAAaATGTGTGCTAATTGGAGTACTATACCAAA

CTTCAGATTTTTGGCCGGAACCTATGACATGTTTTTCTCCCGGATTGAGCATCT

ATATTCAGCAATCAGAGTGGGCACAGTTGTCACTGCTTATGAAGACTGTTCAG

GACTGGTATCATTTACTGGGTTCATAAAACAAATCAATCTCACCGCTAGAGA

GGCAATACTATATTTCTTCCACAAGAACTTTGAGGAAGAGATAAGAAGAATG

TTTGAGCCAGGGCAGGAGACAGCTGTTCCTCACTCTTATTTCATCCACTTCCG

TTCACTAGGCTTGAGTGGGAAATCTCCTTATTCATCAAATGCTGTTGGTCACG

TGTTCAATCTCATTCACTTTGTAGGATGCTATATGGGTCAAGTCAGATCCCTA

AATGCAACGGTTATTGCTGCATGTGCTCCTCATGAAATGTCTGTTCTAGGGGG

CTATCTGGGAGAGGAATTCTTCGGGAAAGGGACATTTGAAAGAAGATTCTTC

AGAGATGAGAAAGAACTTCAAGAATACGAGGCGGCTGAACTGACAAAGACT

GACGTAGCACTGGCAGATGATGGAACTGTCAACTCTGACGACGAGGACTACT

TTTCAGGTGAAACCAGAAGTCCGGAGGCTGTTTATACTCGAATCATGATGAA

T GGAGGTCGACT AAAGAGATCTC AC AT ACGGAGAT ATGTCTC AGT C AGTTCC

AATCATCAAGCCCGTCCAAACTCATTCGCCGAGTTTCTAAAC AAGAC ATATTC

GAGTGACTCATAAcatgaaaaaaactaacacccctcccGTACGCCACCATGTTCGTGTTTCT GGTGCTGCTGCCTCTGGTGAGCTCCCAGTGCGTGAACCTGACCACAAGGACC

CAGCTGCCCCCTGCCTATACCAATTCCTTCACACGGGGCGTGTACTATCCCGA

CAAGGTGTTCCGGAGCAGCGTGCTGCACTCCACACAGGATCTGTTTCTGCCTT

TCTTTTCTAACGTGACCTGGTTCCACGCCATCCACGTGAGCGGCACCAATGGC

ACAAAGCGGTTCGACAATCCAGTGCTGCCCTTTAACGATGGCGTGTACTTCGC

CTCCACCGAGAAGTCTAACATCATCAGAGGCTGGATCTTTGGCACCACACTG

GACAGCAAGACACAGTCCCTGCTGATCGTGAACAATGCCACCAACGTGGTCA

TCAAGGTGTGCGAGTTCCAGTTTTGTAATGATCCATTCCTGGGCGTGTACTAT

CACAAGAACAATAAGTCTTGGATGGAGAGCGAGTTTCGCGTGTATTCCTCTG

CCAACAATTGCACATTTGAGTACGTGTCCCAGCCCTTCCTGATGGACCTGGAG

GGC AAGC AGGGC AATTT C AAGAACCTGAGGGAGTTCGT GTTT AAGAAT ATCG

ATGGCTACTTCAAAATCTACTCCAAGCACACCCCAATCAACCTGGTGCGCGA

CCTGCCACAGGGCTTCTCTGCCCTGGAGCCACTGGTGGATCTGCCCATCGGCA

TCAACATCACCCGGTTTCAGACACTGCTGGCCCTGCACAGAAGCTACCTGAC

ACCAGGCGACAGCTCCTCTGGATGGACCGCAGGAGCAGCAGCCTACTATGTG

GGCTATCTGCAGCCCAGGACCTTCCTGCTGAAGTACAACGAGAATGGCACCA

TCACAGACGCCGTGGATTGCGCCCTGGATCCCCTGTCTGAGACCAAGTGTAC

ACTGAAGAGCTTTACCGTGGAGAAGGGCATCTATCAGACAAGCAATTTCAGG

GTGCAGCCTACCGAGTCCATCGTGCGCTTTCCCAATATCACAAACCTGTGCCC

TTTTGGCGAGGTGTTCAACGCAACCCGCTTCGCCAGCGTGTACGCCTGGAATA

GGAAGCGCATCTCCAACTGCGTGGCCGACTATTCTGTGCTGTACAACAGCGC

CTCCTTCTCTACCTTTAAGTGCTATGGCGTGAGCCCCACAAAGCTGAATGACC

TGTGCTTTACCAACGTGTACGCCGATTCCTTCGTGATCAGGGGCGACGAGGTG

CGCCAGATCGCACCAGGACAGACAGGCAAGATCGCAGACTACAATTATAAGC

TGCCTGACGATTTCACCGGCTGCGTGATCGCCTGGAACTCTAACAATCTGGAT

AGCAAAGTGGGCGGCAACTACAATTATCTGTACCGGCTGTTTAGAAAGTCTA

ATCTGAAGCCATTCGAGAGGGACATCTCCACAGAAATCTACCAGGCCGGCTC

TACCCCCTGCAATGGCGTGGAgGGCTTTAACTGTTATTTCCCTCTGCAGAgCTA

CgGCTTCCAGCCAACAAACGGCGTGGGCTATCAGCCCTACCGCGTGGTGGTGC

TGTCTTTTGAGCTGCTGCACGCACcTGCAACAGTGTGCGGACCAAAGAAGAGC

ACCAATCTGGTGAAGAACAAGTGCGTGAACTTCAACTTCAACGGACTGACCG

GAACAGGCGTGCTGACCGAGTCCAACAAGAAGTTCCTGCCTTTTCAGCAGTT

CGGCAGGGACATCGCAGATACCACAGACGCCGTGCGCGACCCTCAGACCCTG

GAGATCCTGGACATCACACCATGCTCCTTCGGCGGCGTGTCTGTGATCACACC AGGCACCAATACAAGCAACCAGGTGGCCGTGCTGTATCAGGACGTGAATTGT

ACCGAGGTGCCAGTGGCAATCCACGCAGATCAGCTGACCCCTACATGGCGGG

TGTACTCTACCGGCAGCAACGTGTTCCAGACAAGAGCCGGATGCCTGATCGG

AGCAGAGCACGTGAACAATAGCTATGAGTGCGACATCCCTATCGGCGCCGGC

ATCTGTGCCTCCTACCAGACCCAGACAAACTCCCCAAGGTCTGTGGGAGATG

AGGCCGAAGACTTTGTGGAAGTCCACCTGCCTGATGTGCATAACCAGGTGTC

TGGCGTCGACCTGGGACTGCCAAATTGGGGCAAGTACGTGCTGCTGAGTGCT

GGAGCACTGACTGCCCTGATGCTGATCATTTTCCTGATGACCTGCTGTCGGCG

CGTGAACAGAAGTGAGCCCACTCAGCACAATCTGCGAGGAACCGGGAGAGA

AGTGTCAGTCACACCTCAGAGCGGGAAAATCATTAGTAGTTGGGAATCACAT

AAAAGCGGGGGCGAGACCAGGCTGTGAGCTAGCCATGAAAAAAACTAACAC

CCCTCCTTTCGAACCATCCCAAACATGAGCAAGATCTTTGTCAATCCTAGTGC

TATTAGAGCCGGTCTGGCCGATCTTGAGATGGCTGAAGAAACTGTTGATCTG

AT C A AT AGA A AT ATCGA AGAC A AT C AGGCTC ATCTC C A AGGGGA ACC C AT AG

AGGTGGACAATCTCCCTGAGGATATGGGGCGACTTCACCTGGATGATGGAAA

ATCGCCC AACC AT GGT GAG AT AGCC AAGGTGGGAGAAGGC AAGT ATCGAGA

GGACTTTCAGATGGATGAAGGAGAGGATCCTAGCTTCCTGTTCCAGTCATACC

T GGA A A AT GTT GGAGT C C A A AT AGT C AGAC A A AT GAGGT C AGG AGAGAGATT

TCTCAAGATATGGTCACAGACCGTAGAAGAGATTATATCCTATGTCGCGGTC

AACTTTCCCAACCCTCCAGGAAAGTCTTCAGAGGATAAATCAACCCAGACTA

CTGGCCGAGAGCTC AAGAAGGAGAC AAC ACCC ACTCCTTCTC AGAGAGA AAG

CCAATCATCGAAAGCCAGGATGGCGGCTCAAATTGCTTCTGGCCCTCCAGCC

CTTGAATGGTCGGCTACCAATGAAGAGGATGATCTATCAGTGGAGGCTGAGA

TCGCTCACCAGATTGCAGAAAGTTTCTCCAAAAAATATAAGTTTCCCTCTCGA

TCCTCAGGGATACTCTTGTATAATTTTGAGCAATTGAAAATGAACCTTGATGA

TATAGTTAAAGAGGCAAAAAATGTACCAGGTGTGACCCGTTTAGCCCATGAC

GGGTCCAAACTCCCCCTAAGATGTGTACTGGGATGGGTCGCTTTGGCCAACTC

TAAGAAATTCCAGTTGTTAGTCGAATCCGACAAGCTGAGTAAAATCATGCAA

GATGACTTGAATCGCTATACATCTTGCTAACCGAACCTCTCCCCTCAGTCCCT

CTAGACAATAAAATCCGAGATGTCCCAAAGTCAACATGAAAAAAACAGGCA

ACACCACTGATAAAATGAACCTCCTACGTAAGATAGTGAAAAACCGCAGGGA

CGAGGACACTCAAAAATCCTCTCCCGCGTCAGCCCCTCTGGATGACGATGAC

TTGTGGCTTCCACCCCCTGAATACGTCCCGCTGAAAGAACTTACAGGCAAGA

AGAACATGAGGAACTTTTGTATCAACGGAAGGGTTAAAGTGTGTAGCCCGAA TGGTTACTCGTTCAGGATCCTGCGGCACATTCTGAAATCATTCGACGAGATAT

ATTCTGGGAATCATAGGATGATCGGGTTAGTCAAAGTGGTTATTGGACTGGCT

TTGTCAGGATCTCCAGTCCCTGAGGGCCTGAACTGGGTATACAAATTGAGGA

GAACCTTTATCTTCCAGTGGGCTGATTCCAGGGGCCCTCTTGAAGGGGAGGA

GT T GG A AT AC T C T C AGG AG AT C AC TT GGG AT GAT GAT ACT G AGT T C GT C GG AT

T GCA A AT A AGAGT GATT GC A A A AC AGT GT CAT AT C C AGGGC AGAGTCTGGT G

TATCAACATGAACCCGAGAGCATGTCAACTATGGTCTGACATGTCTCTTCAGA

CACAAAGGTCCGAAGAGGACAAAGATTCCTCTCTGCTTCTAGAATAATCAGA

TTATATCCCGCAAATTTATCACTTGTTTACCTCTGGAGGAGAGAACATATGGG

CTCAACTCCAACCCTTGGGAGCAATATAACAAAAAACATGTTATGGTGCCAT

TAAACCGCTGCATTTCATCAAAGTCAAGTTGATTACCTTTACATTTTGATCCTC

TTGGATGTGAAAAAAACTATTAACATCCCTCAAAAGACcccgggAAAGATGGTT

CCTCAGGCTCTCCTGTTTGTACCCCTTCTGGTTTTTCCATTGTGTTTTGGGAAA

TTCCCTATTTACACGATACCAGACAAGCTTGGTCCCTGGAGTCCGATTGACAT

ACATCACCTCAGCTGCCCAAACAATTTGGTAGTGGAGGACGAAGGATGCACC

AACCTGTCAGGGTTCTCCTACATGGAACTTAAAGTTGGATACATCTTAGCCAT

A A A AGT GA AC GGGTT C AC TT GC AC AGGC GTT GT GACGGAGGC T GA A AC CT AC

ACTAACTTCGTTGGTTATGTCACAACCACGTTCAAAAGAAAGCATTTCCGCCC

AACACCAGATGCATGTAGAGCCGCGTACAACTGGAAGATGGCCGGTGACCCC

AGATATGAAGAGTCTCTACACAATCCGTACCCTGACTACCGCTGGCTTCGAAC

TGTAAAAACCACCAAGGAGTCTCTCGTTATCATATCTCCAAGTGTGGCAGATT

TGGACCCATATGACAGATCCCTTCACTCGAGGGTCTTCCCTAGCGGGAAGTGC

TCAGGAGTAGCGGTGTCTTCTACCTACTGCTCCACTAACCACGATTACACCAT

TTGGATGCCCGAGAATCCGAGACTAGGGATGTCTTGTGACATTTTTACCAATA

GT AGAGGGAAGAGAGC ATCC AAAGGGAGT GAGACTT GCGGCTTTGT AGAT G

AAAGAGGCCTATATAAGTCTTTAAAAGGAGCATGCAAACTCAAGTTATGTGG

AGTTCTAGGACTTAGACTTATGGATGGAACATGGGTCTCGATGCAAACATCA

AATGAAACCAAATGGTGCCCTCCCGATAAGTTGGTGAACCTGCACGACTTTC

GCTC AGACGAAATTGAGC ACCTT GTT GT AGAGGAGTTGGT C AGGAAGAGAGA

GGAGT GTCTGGAT GC AC T AGAGT C CAT CAT GAC A AC C A AGT C AGT GAGTTT C

AGACGTCTCAGTCATTTAAGAAAACTTGTCCCTGGGTTTGGAAAAGCATATAC

CAT ATT C A AC A AGAC CTT GAT GGA AGCC GAT GCTC AC T AC A AGT C AGT Cgag A

CTTGGAATGAGATCCTCCCTTCAAAAGGGTGTTTAAGAGTTGGGGGGAGGTG

TCATCCTCATGTGAACGGGGTGTTTTTCAATGGTATAATATTAGGACCTGACG GCAATGTCTTAATCCCAGAGATGCAATCATCCCTCCTCCAGCAACATATGGAG

TTGTTGGAATCCTCGGTTATCCCCCTTGTGCACCCCCTGGCAGACCCGTCTAC

CGTTTTCAAGGACGGTGACGAGGCTGAGGATTTTGTTGAAGTTCACCTTCCCG

ATGTGCACAATCAGGTCTCAGGAGTTGACTTGGGTCTCCCGAACTGGGGGAA

GTATGTATTACTGAGTGCAGGGGCCCTGACTGCCTTGATGTTGATAATTTTCC

T GAT GAC AT GTT GT AGA AGAGT C A ATCGAT C AGA AC CT ACGC A AC AC A ATCT

CAGAGGGACAGGGAGGGAGGTGTCAGTCACTCCCCAAAGCGGGAAGATCAT

ATCTT CAT GGGAAT C AC AC AAGAGT GGGGGTGAGACC AGACTGT AAttaattaaCG

TCCTTTCAACGATCCAAGTCcatgaaaaaaactaacacccctcccgtacctagcTTATAAAGTGCT

GGGT C ATCT AAGCTTTTCAGTCGAGAAAAAAAC ATT AGATCAGAAGAACAAC

TGGCAACACTTCTCAACCTGAGACTTACTTCAAGATGCTCGATCCTGGAGAGG

TCTATGATGACCCTATTGACCCAATCGAGTTAGAGGCTGAACCCAGAGGAAC

CCCCATTGTCCCCAACATCTTGAGGAACTCTGACTACAATCTCAACTCTCCTT

T GAT AG A AG AT C C T GC T AG AC T A AT GT T AG A AT GGTT A A A A AC AGGG A AT AG

ACCTTATCGGATGACTCTAACAGACAATTGCTCCAGGTCTTTCAGAGTTTTGA

AAGATTATTTCAAGAAGGTAGATTTGGGTTCTCTCAAGGTGGGCGGAATGGC

TGCACAGTCAATGATTTCTCTCTGGTTATATGGTGCCCACTCTGAATCCAACA

GGAGCCGGAGATGTATAACAGACTTGGCCCATTTCTATTCCAAGTCGTCCCCC

ATAGAGAAGCTGTTGAATCTCACGCTAGGAAATAGAGGGCTGAGAATCCCCC

C AGAGGGAGT GTT A AGTT GCC TT GAGAGGGTT GATT AT GAT A AT GC ATTTGG

AAGGTATCTTGCCAACACGTATTCCTCTTACTTGTTCTTCCATGTAATCACCTT

ATACATGAACGCCCTAGACTGGGATGAAGAAAAGACCATCCTAGCATTATGG

AAAGATTTAACCTCAGTGGACATCGGGAAGGACTTGGTAAAGTTCAAAGACC

AAATATGGGGACTGCTGATCGTGACAAAGGACTTTGTTTACTCCCAAAGTTCC

AATTGTCTTTTTGACAGAAACTACACACTTATGCTAAAAGATCTTTTCTTGTCT

CGCTTCAACTCCTTAATGGTCTTGCTCTCTCCCCCAGAGCCCCGATACTCAGA

TGACTTGATATCTCAACTATGCCAGCTGTACATTGCTGGGGATCAAGTCTTGT

CTATGTGTGGAAACTCCGGCTATGAAGTCATCAAAATATTGGAGCCATATGTC

GTGAATAGTTTAGTCCAGAGAGCAGAAAAGTTTAGGCCTCTCATTCATTCCTT

GGG AG AC TT TC C T GT AT TT AT A A A AG AC A AGGT A AGT C A AC TT G A AG AG AC G

TTCGGTCCCTGTGCAAGAAGGTTCTTTAGGGCTCTGGATCAATTCGACAACAT

ACATGACTTGGTTTTTGTGTTTGGCTGTTACAGGCATTGGGGGCACCCATATA

TAGATTATCGAAAGGGTCTGTCAAAACTATATGATCAGGTTCACCTTAAAAA

A AT GAT AG AT A AGTCC T AC C AGGAGT GC TT AGC A AGC GACC T AGC C AGGAGG ATCCTTAGATGGGGTTTTGATAAGTACTCCAAGTGGTATCTGGATTCAAGATT

CCTAGCCCGAGACCACCCCTTGACTCCTTATATCAAAACCCAAACATGGCCAC

CCAAACATATTGTAGACTTGGTGGGGGATACATGGCACAAGCTCCCGATCAC

GCAGATCTTTGAGATTCCTGAATCAATGGATCCGTCAGAAATATTGGATGAC

AAATCACATTCTTTCACCAGAACGAGACTAGCTTCTTGGCTGTCAGAAAACCG

AGGGGGGCCTGTTCCTAGCGAAAAAGTTATTATCACGGCCCTGTCTAAGCCG

CCTGTCAATCCCCGAGAGTTTCTGAGGTCTATAGACCTCGGAGGATTGCCAGA

TGAAGACTTGATAATTGGCCTCAAGCCAAAGGAACGGGAATTGAAGATTGAA

GGTCGATTCTTTGCTCTAATGTCATGGAATCTAAGATTGTATTTTGTCATCACT

GAAAAACTCTTGGCCAACTACATCTTGCCACTTTTTGACGCGCTGACTATGAC

AGACAACCTGAACAAGGTGTTTAAAAAGCTGATCGACAGGGTCACCGGGCAA

GGGCTTTTGGACTATTCAAGGGTCACATATGCATTTCACCTGGACTATGAAAA

GT GGAAC AACC AT C A AAGATT AGAGT C AAC AGAGGAT GT ATTTTCTGTCCT A

GATCAAGTGTTTGGATTGAAGAGAGTGTTTTCTAGAACACACGAGTTTTTTCA

AAAGGCCTGGATCTATTATTCAGACAGATCAGACCTCATCGGGTTACGGGAG

GATCAAATATACTGCTTAGATGCGTCCAACGGCCCAACCTGTTGGAATGGCC

AGGATGGCGGGCTAGAAGGCTTACGGCAGAAGGGCTGGAGTCTAGTCAGCTT

ATTGAT GAT AG AT AGAG A AT C TC A A AT C AGGA AC AC A AGA AC C A A A AT AC T A

GCTCAAGGAGACAACCAGGTTTTATGTCCGACATACATGTTGTCGCCAGGGC

T ATC T C A AG AGGGGC TCCTCTAT G A AT T GG AG AG A AT AT C A AGGA AT GC AC T

TTCGATATACAGAGCCGTCGAGGAAGGGGCATCTAAGCTAGGGCTGATCATC

AAGAAAGAAGAGACCATGTGTAGTTATGACTTCCTCATCTATGGAAAAACCC

CTTT GTTT AGAGGT A AC AT ATT GGT GCC T GAGT C C A A A AG AT GGGC C AGAGT

CTCTTGCGTCTCTAATGACCAAATAGTCAACCTCGCCAATATAATGTCGACAG

TGTCCACCAATGCGCTAACAGTGGCACAACACTCTCAATCTTTGATCAAACCG

ATGAGGGATTTTCTGCTCATGTCAGTACAGGCAGTCTTTCACTACCTGCTATT

T AGCCC AATCTT AAAGGGA AGAGTTT AC AAGATTCTGAGCGCTGAAGGGGAG

AGCTTTCTCCTAGCCATGTCAAGGATAATCTATCTAGATCCTTCTTTGGGAGG

GATATCTGGAATGTCCCTCGGAAGATTCCATATACGACAGTTCTCAGACCCTG

TCTCTGAAGGGTTATCCTTCTGGAGAGAGATCTGGTTAAGCTCCCAAGAGTCC

T GGATT C ACGCGTT GT GT C AAGAGGCTGGAAACCC AGATCTTGGAGAGAGAA

CACTCGAGAGCTTCACTCGCCTTCTAGAAGATCCGACCACCTTAAATATCAGA

GGAGGGGCCAGTCCTACCATTCTACTCAAGGATGCAATCAGAAAGGCTTTAT

AT GACGAGGT GGAC AAGGTGGAAAATT C AGAGTTTCGAGAGGC AATCCTGTT GTCCAAGACCCATAGAGATAATTTTATACTCTTCTTAATATCTGTTGAGCCTC

TGTTTCCTCGATTTCTCAGTGAGCTATTCAGTTCGTCTTTTTTGGGAATCCCCG

AGTCAATCATTGGATTGATACAAAACTCCCGAACGATAAGAAGGCAGTTTAG

AAAGAGTCTCTCAAAAACTTTAGAAGAATCCTTCTACAACTCAGAGATCCAC

GGGATTAGTCGGATGACCCAGACACCTCAGAGGGTTGGGGGGGTGTGGCCTT

GCTCTTCAGAGAGGGCAGATCTACTTAGGGAGATCTCTTGGGGAAGAAAAGT

GGTAGGCACGACAGTTCCTCACCCTTCTGAGATGTTGGGATTACTTCCCAAGT

CCTCTATTTCTTGCACTTGTGGAGCAACAGGAGGAGGCAATCCTAGAGTTTCT

GTATCAGTACTCCCGTCCTTTGATCAGTCATTTTTTTCACGAGGCCCCCTAAA

GGGATACTTGGGCTCGTCCACCTCTATGTCGACCCAGCTATTCCATGCATGGG

A A A A AGT C AC T A AT GT TC AT GT GGT G A AG AG AGC TC T AT C GT T A A A AG A AT C

TATAAACTGGTTCATTACTAGAGATTCCAACTTGGCTCAAGCTCTAATTAGGA

ACATTATGTCTCTGACAGGCCCTGATTTCCCTCTAGAGGAGGCCCCTGTCTTC

AAAAGGACGGGGTCAGCCTTGCATAGGTTCAAGTCTGCCAGATACAGCGAAG

GAGGGTATTCTTCTGTCTGCCCGAACCTCCTCTCTCATATTTCTGTTAGTACAG

ACACCATGTCTGATTTGACCCAAGACGGGAAGAACTACGATTTCATGTTCCA

GCC ATT GATGCTTT ATGC AC AGAC ATGGAC AT C AGAGCTGGT AC AG AG AG AC

ACAAGGCTAAGAGACTCTACGTTTCATTGGCACCTCCGATGCAACAGGTGTG

TGAGACCCATTGACGACGTGACCCTGGAGACCTCTCAGATCTTCGAGTTTCCG

GATGTGTCGAAAAGAATATCCAGAATGGTTTCTGGGGCTGTGCCTCACTTCCA

GAGGCTTCCCGATATCCGTCTGAGACCAGGAGATTTTGAATCTCTAAGCGGTA

GAGAAAAGTCTCACCATATCGGATCAGCTCAGGGGCTCTTATACTCAATCTTA

GTGGCAATTCACGACTCAGGATACAATGATGGAACCATCTTCCCTGTCAACAT

ATACGGCAAGGTTTCCCCTAGAGACTATTTGAGAGGGCTCGCAAGGGGAGTA

TTGATAGGATCCTCGATTTGCTTCTTGACAAGAATGACAAATATCAATATTAA

TAGACCTCTTGAATTGGTCTCAGGGGTAATCTCATATATTCTCCTGAGGCTAG

ATAACCATCCCTCCTTGTACATAATGCTCAGAGAACCGTCTCTTAGAGGAGAG

ATATTTTCTATCCCTCAGAAAATCCCCGCCGCTTATCCAACCACTATGAAAGA

AGGCAACAGATCAATCTTGTGTTATCTCCAACATGTGCTACGCTATGAGCGAG

AGATAATCACGGCGTCTCCAGAGAATGACTGGCTATGGATCTTTTCAGACTTT

AGAAGTGCCAAAATGACGTACCTATCCCTCATTACTTACCAGTCTCATCTTCT

ACTCC AGAGGGTTGAGAGAAACCT ATCT AAGAGT AT GAGAGAT A ACCTGCGA

CAATTGAGTTCTTTGATGAGGCAGGTGCTGGGCGGGCACGGAGAAGATACCT

TAGAGTCAGACGACAACATTCAACGACTGCTAAAAGACTCTTTACGAAGGAC AAGAT GGGTGGATC AAGAGGT GCGCC ATGC AGCT AGAACC AT GACTGGAGAT

T AC AGCCCC AAC AAGAAGGT GTCCCGT AAGGT AGGATGTT C AGAAT GGGTCT

GCTCTGCTCAACAGGTTGCAGTCTCTACCTCAGCAAACCCGGCCCCTGTCTCG

GAGCTTGACATAAGGGCCCTCTCTAAGAGGTTCCAGAACCCTTTGATCTCGGG

CTTGAGAGTGGTTCAGTGGGCAACCGGTGCTCATTATAAGCTTAAGCCTATTC

TAGATGATCTCAATGTTTTCCCATCTCTCTGCCTTGTAGTTGGGGACGGGTCA

GGGGGGATATCAAGGGCAGTCCTCAACATGTTTCCAGATGCCAAGCTTGTGT

TCAACAGTCTTTTAGAGGTGAATGACCTGATGGCTTCCGGAACACATCCACTG

CCTCCTTCAGCAATCATGAGGGGAGGAAATGATATCGTCTCCAGAGTGATAG

ATCTTGACTCAATCTGGGAAAAACCGTCCGACTTGAGAAACTTGGCAACCTG

GAAATACTTCCAGTCAGTCCAAAAGCAGGTCAACATGTCCTATGACCTCATTA

TTTGCGATGCAGAAGTTACTGACATTGCATCTATCAACCGGATCACCCTGTTA

ATGTCCGATTTTGCATTGTCTATAGATGGACCACTCTATTTGGTCTTCAAAACT

TATGGGACTATGCTAGTAAATCCAAACTACAAGGCTATTCAACACCTGTCAA

GAGCGTTCCCCTCGGTCACAGGGTTTATCACCCAAGTAACTTCGTCTTTTTCA

TCTGAGCTCTACCTCCGATTCTCCAAACGAGGGAAGTTTTTCAGAGATGCTGA

GTACTTGACCTCTTCCACCCTTCGAGAAATGAGCCTTGTGTTATTCAATTGTA

GCAGCCCCAAGAGTGAGATGCAGAGAGCTCGTTCCTTGAACTATCAGGATCT

TGTGAGAGGATTTCCTGAAGAAATCATATCAAATCCTTACAATGAGATGATC

ATAACTCTGATTGACAGTGATGTAGAATCTTTTCTAGTCCACAAGATGGTTGA

TGATCTTGAGTTACAGAGGGGAACTCTGTCTAAAGTGGCTATCATTATAGCCA

TCATGATAGTTTTCTCCAACAGAGTCTTCAACGTTTCCAAACCCCTAACTGAC

CCCTCGTTCTATCCACCGTCTGATCCCAAAATCCTGAGGCACTTCAACATATG

TTGCAGTACTATGATGTATCTATCTACTGCTTTAGGTGACGTCCCTAGCTTCGC

AAGACTTCACGACCTGTATAACAGACCTATAACTTATTACTTCAGAAAGCAA

GTCATTCGAGGGAACGTTTATCTATCTTGGAGTTGGTCCAACGACACCTCAGT

GTTCAAAAGGGTAGCCTGTAATTCTAGCCTGAGTCTGTCATCTCACTGGATCA

GGTTGATTTACAAGATAGTGAAGACTACCAGACTCGTTGGCAGCATCAAGGA

TCT ATCC AGAGAAGT GGAAAGAC ACCTT CAT AGGT AC AAC AGGTGGAT C ACC

CTAGAGGATATCAGATCTAGATCATCCCTACTAGACTACAGTTGCCTGTGAAC

CGGATACTCCTGGAAGCCTGCCCATGCTAAGACTCTTGTGTGATGTATCTTGA

AAAAAAC AAGATCCT AAATCTGAACCTTTGGTT GTTT GATT GTTTTTCTC Atttttg ttgtttatttgttaagcgtGGGTCGGCATGGCATCTCCACCTCCTCGCGGTCCGACCTGGGC

ATCCGAAGGAGGACGCACGTCCACTCGGATGGCTAAGGGAGagccagaaGGATC CGGCTGCTAACAAAGCCCGAAAGGAAGCTGAGTTGGCTGCTGCCACCGCTGA

GCAATAACTAGCATAACCCCTTGGGGCCTCTAAACGGGTCTTGAGGGGTTTTT

T GCTGAAAGtCGCGCTT GGCGT AAT CAT GGT CAT AGCTGTTTCCTGTGT GAAA

TTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGT

AAAGCCTGGGGT GCCT AAT GAGTGAGCT A ACTC AC ATT AATT GCGTTGCGCTC

ACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCG

GCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTaCGCTTCCTCG

CTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCA

CTC AAAGGCGGT AAT ACGGTT ATCC AC AGAAT C AGGGGAT AACGC AGGAAA

GAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGC

GTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATC

GAC GCTC A AGT C AGAGGT GGC GA A AC CCG AC AGGAC T AT A A AG AT ACC AGG

CGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTA

CCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGC

TCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTG

TGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATC

GTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCAC

TGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTG

AAGTGGTGGCCTAACTACGGCTACACTAGAAGGACAGTATTTGGTATCTGCG

CTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGC

AAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTAC

GCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCT

GAC GCTC AGT GGAACGAA AACTC ACGTT AAGGGATTTT GGT C ATGAGATT AT

CAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCA

ATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAG

TGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACT

CCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGT

GCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAA

T AAACC AGCC AGCCGGAAGGGCCGAGCGC AGAAGT GGTCCTGC AACTTT ATC

CGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGC

CAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCA

CGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCG

AGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTC

CGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCA GCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACT

GGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTT

GCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTT

AAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATC

TTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATC

TTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGC

A A A AT GCC GC A A A A A AGGGA AT A AGGGC GAC AC GGA A AT GTT GA AT ACTC A

TACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGA

GCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCG

CACATTTCCCCGAAAAGTGCCAC.

In one embodiment, the nucleic acid comprises a sequence encoding at least a portion of the genome of a measles virus and (b) a sequence encoding a SARS-CoV-2 spike protein (S) or a portion thereof. In some embodiments, the sequence encoding the SARS-CoV-2 spike protein (S) or portion thereof is inserted into position 2, 3, or 6 of the genome of the measles virus.

In one embodiment, the nucleic acid comprises the sequence of SEQ ID NO: 3, shown below:

GGACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGC

AGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTT

CCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGG

GGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAA

CTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTT

TCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAA

CTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATT

TTGCCGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAA

CGCGAATTTTAACAAAATATTAACGTTTACAATTTCGCGCCATTCGCCATTCA

GGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACG

CCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCA

GGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAGTGCGCGCCGTTAAT

ACGACTCACTATAGGGAGACCCAAGCTGGCTAGCTTTGTTTGGTCTGATGAGT

CCCGTGAGGACGAAACCCGGCGTACCGGGTCACCAAACAAAGTTGGGTAAG

GATAGTTCAATCAATGATCATCTTCTAGTGCACTTAGGATTCAAGATCCTATT

AT C AGGGAC AAGAGC AGGATT AGGGAT ATCCGAGAT GGCC AC ACTTTT A AGG

AGCTTAGCATTGTTCAAAAGAAACAAGGACAAACCACCCATTACATCAGGAT CCGGTGGAGCCATCAGAGGAATCAAACACATTATTATAGTACCAATCCCTGG

AGATTCCTCAATTACCACTCGATCCAGACTTCTGGACCGGTTGGTGAGGTTAA

TTGGAAACCCGGATGTGAGCGGGCCCAAACTAACAGGGGCACTAATAGGTAT

ATTATCCTTATTTGTGGAGTCTCCAGGTCAATTGATTCAGAGGATCACCGATG

ACCCTGACGTTAGCATAAGGCTGTTAGAGGTTGTCCAGAGTGACCAGTCACA

ATCTGGCCTTACCTTCGCATCAAGAGGTACCAACATGGAGGATGAGGCGGAC

CAATACTTTTCACATGATGATCCAATTAGTAGTGATCAATCCAGGTTCGGATG

GTTCGGGAAC AAGGAAATCTC AGAT ATTGAAGT GC AAGACCCTGAGGGATT C

AACATGATTCTGGGTACCATCCTAGCCCAAATTTGGGTCTTGCTCGCAAAGGC

GGTTACGGCCCCAGACACGGCAGCTGATTCGGAGCTAAGAAGGTGGATAAAG

TACACCCAACAAAGAAGGGTAGTTGGTGAATTTAGATTGGAGAGAAAATGGT

TGGATGTGGTGAGGAACAGGATTGCCGAGGACCTCTCCTTACGCCGATTCAT

GGTCGCTCTAATCCTGGATATCAAGAGAACACCCGGAAACAAACCCAGGATT

GCTGAAAT GAT ATGT GAC ATTGAT AC AT AT ATCGT AGAGGC AGGATT AGCC A

GTTTTATCCTGACTATTAAGTTTGGGATAGAAACTATGTATCCTGCTCTTGGA

CTGCATGAATTTGCTGGTGAGTTATCCACACTTGAGTCCTTGATGAACCTTTA

CCAGCAAATGGGGGAAACTGCACCCTACATGGTAATCCTGGAGAACTCAATT

CAGAACAAGTTCAGTGCAGGATCATACCCTCTGCTCTGGAGCTATGCCATGG

GAGT AGGAGT GGAACTTGAAAACTCC AT GGGAGGTTT GAACTTT GGCCGATC

TTACTTTGATCCAGCATATTTTAGATTAGGGCAAGAGATGGTAAGGAGGTCA

GCTGGAAAGGT C AGTTCC AC ATT GGC ATCTGAACTCGGT AT C ACTGCCGAGG

AT GC AAGGCTT GTTTC AGAGATTGC AAT GC AT ACT ACTGAGGAC A AGATC AG

TAGAGCGGTTGGACCCAGACAAGCCCAAGTATCATTTCTACACGGTGATCAA

AGTGAGAATGAGCTACCGAGATTGGGGGGCAAGGAAGATAGGAGGGTCAAA

C AGAGT C GAGGAGA AGC C AGGGAGAGCT AC AGAGA A ACC GGGCC C AGC AGA

GCAAGTGATGCGAGAGCTGCCCATCTTCCAACCGGCACACCCCTAGACATTG

ACACTGCAACGGAGTCCAGCCAAGATCCGCAGGACAGTCGAAGGTCAGCTGA

CGCCCTGCTT AGGCTGC AAGCC AT GGC AGGAATCTCGGAAGAAC AAGGCTC A

GACACGGACACCCCTATAGTGTACAATGACAGAAATCTTCTAGACTAGGTGC

GAGAGGCCGAGGGCCAGAACAACATCCGCCTACCATCCATCATTGTTATAAA

AAACTTAGGAACCAggtccacacaGagtgatACGCGTACGCCACCATGTTCGTGTTTCT

GGTGCTGCTGCCTCTGGTGAGCTCCCAGTGCGTGAACCTGACCACAAGGACC

CAGCTGCCCCCTGCCTATACCAATTCCTTCACACGGGGCGTGTACTATCCCGA

CAAGGTGTTCCGGAGCAGCGTGCTGCACTCCACACAGGATCTGTTTCTGCCTT TCTTTTCTAACGTGACCTGGTTCCACGCCATCCACGTGAGCGGCACCAATGGC

ACAAAGCGGTTCGACAATCCAGTGCTGCCCTTTAACGATGGCGTGTACTTCGC

CTCCACCGAGAAGTCTAACATCATCAGAGGCTGGATCTTTGGCACCACACTG

GACAGCAAGACACAGTCCCTGCTGATCGTGAACAATGCCACCAACGTGGTCA

TCAAGGTGTGCGAGTTCCAGTTTTGTAATGATCCATTCCTGGGCGTGTACTAT

CACAAGAACAATAAGTCTTGGATGGAGAGCGAGTTTCGCGTGTATTCCTCTG

CCAACAATTGCACATTTGAGTACGTGTCCCAGCCCTTCCTGATGGACCTGGAG

GGC AAGC AGGGC AATTT C AAGAACCTGAGGGAGTTCGT GTTT AAGAAT ATCG

ATGGCTACTTCAAAATCTACTCCAAGCACACCCCAATCAACCTGGTGCGCGA

CCTGCCACAGGGCTTCTCTGCCCTGGAGCCACTGGTGGATCTGCCCATCGGCA

TCAACATCACCCGGTTTCAGACACTGCTGGCCCTGCACAGAAGCTACCTGAC

ACCAGGCGACAGCTCCTCTGGATGGACCGCAGGAGCAGCAGCCTACTATGTG

GGCTATCTGCAGCCCAGGACCTTCCTGCTGAAGTACAACGAGAATGGCACCA

TCACAGACGCCGTGGATTGCGCCCTGGATCCCCTGTCTGAGACCAAGTGTAC

ACTGAAGAGCTTTACCGTGGAGAAGGGCATCTATCAGACAAGCAATTTCAGG

GTGCAGCCTACCGAGTCCATCGTGCGCTTTCCCAATATCACAAACCTGTGCCC

TTTTGGCGAGGTGTTCAACGCAACCCGCTTCGCCAGCGTGTACGCCTGGAATA

GGAAGCGCATCTCCAACTGCGTGGCCGACTATTCTGTGCTGTACAACAGCGC

CTCCTTCTCTACCTTTAAGTGCTATGGCGTGAGCCCCACAAAGCTGAATGACC

TGTGCTTTACCAACGTGTACGCCGATTCCTTCGTGATCAGGGGCGACGAGGTG

CGCCAGATCGCACCAGGACAGACAGGCAAGATCGCAGACTACAATTATAAGC

TGCCTGACGATTTCACCGGCTGCGTGATCGCCTGGAACTCTAACAATCTGGAT

AGCAAAGTGGGCGGCAACTACAATTATCTGTACCGGCTGTTTAGAAAGTCTA

ATCTGAAGCCATTCGAGAGGGACATCTCCACAGAAATCTACCAGGCCGGCTC

TACCCCCTGCAATGGCGTGGAGGGCTTTAACTGTTATTTCCCTCTGCAGAGCT

ACGGCTTCCAGCCAACAAACGGCGTGGGCTATCAGCCCTACCGCGTGGTGGT

GCTGTCTTTTGAGCTGCTGCACGCACCTGCAACAGTGTGCGGACCAAAGAAG

AGCACCAATCTGGTGAAGAACAAGTGCGTGAACTTCAACTTCAACGGACTGA

CCGGAACAGGCGTGCTGACCGAGTCCAACAAGAAGTTCCTGCCTTTTCAGCA

GTTCGGCAGGGACATCGCAGATACCACAGACGCCGTGCGCGACCCTCAGACC

CTGGAGATCCTGGACATCACACCATGCTCCTTCGGCGGCGTGTCTGTGATCAC

ACC AGGC ACC AAT AC AAGC AACC AGGT GGCCGTGCTGT AT C AGGACGT GAAT

TGTACCGAGGTGCCAGTGGCAATCCACGCAGATCAGCTGACCCCTACATGGC

GGGTGTACTCTACCGGCAGCAACGTGTTCCAGACAAGAGCCGGATGCCTGAT CGGAGCAGAGCACGTGAACAATAGCTATGAGTGCGACATCCCTATCGGCGCC

GGCATCTGTGCCTCCTACCAGACCCAGACAAACTCCCCAAGGAGAGCACGGT

CTGTGGCCAGCCAGTCCATCATCGCCTATACCATGAGCCTGGGCGCCGAGAA

TTCCGTGGCCTACTCCAACAATTCTATCGCCATCCCTACCAACTTCACAATCT

CCGTGACCACAGAGATCCTGCCAGTGAGCATGACCAAGACATCCGTGGACTG

CACAATGTATATCTGTGGCGATTCCACCGAGTGCTCTAACCTGCTGCTGCAGT

ACGGCTCTTTTTGTACCCAGCTGAATAGAGCCCTGACAGGCATCGCCGTGGA

GC AGGAC AAGA AC AC AC AGGAGGT GTTCGCCC AGGT GAAGC AAATCT AC AA

GACCCCACCCATCAAGGACTTTGGCGGCTTCAACTTCAGCCAGATCCTGCCCG

ATCCTAGCAAGCCATCCAAGCGGTCTTTTATCGAGGACCTGCTGTTCAACAAG

GTGACCCTGGCCGATGCCGGCTTCATCAAGCAGTATGGCGATTGCCTGGGCG

ACATCGCCGCCAGAGACCTGATCTGTGCCCAGAAGTTTAATGGCCTGACCGT

GCTGCCTCCACTGCTGACAGATGAGATGATCGCCCAGTACACATCTGCCCTGC

TGGCCGGAACCATCACAAGCGGATGGACCTTCGGCGCAGGAGCCGCCCTGCA

GATCCCCTTTGCCATGCAGATGGCCTATCGGTTCAACGGCATCGGCGTGACCC

AGAATGTGCTGTACGAGAACCAGAAGCTGATCGCCAATCAGTTTAACTCCGC

CATCGGCAAGATCCAGGACTCTCTGAGCTCCACAGCCAGCGCCCTGGGCAAG

CTGCAGGATGTGGTGAATCAGAACGCCCAGGCCCTGAATACCCTGGTGAAGC

AGCTGTCTAGCAACTTCGGCGCCATCTCCTCTGTGCTGAATGACATCCTGAGC

CGGCTGGAC AAGGT GGAGGC AGAGGT GC AGATCGACCGGCTGAT C AC AGGC

AGACTGCAGTCCCTGCAGACCTACGTGACACAGCAGCTGATCAGGGCAGCAG

AGATCAGGGCCTCTGCCAATCTGGCCGCCACCAAGATGAGCGAGTGCGTGCT

GGGCCAGTCCAAGAGAGTGGACTTTTGTGGCAAGGGCTATCACCTGATGAGC

TTCCCACAGTCCGCCCCTCACGGAGTGGTGTTTCTGCACGTGACCTACGTGCC

AGCCCAGGAGAAGAACTTCACCACAGCACCAGCAATCTGCCACGATGGCAAG

GCACACTTTCCTAGGGAGGGCGTGTTCGTGAGCAACGGCACCCACTGGTTTGT

GACACAGCGCAATTTCTACGAGCCACAGATCATCACCACAGACAATACATTC

GTGTCCGGCAACTGTGACGTGGTCATCGGCATCGTGAACAATACCGTGTATG

ATCCTCTGCAGCCAGAGCTGGACTCTTTTAAGGAGGAGCTGGATAAGTACTTC

AAGAATCACACCAGCCCCGACGTGGATCTGGGCGACATCTCTGGCATCAATG

CCAGCGTGGTGAACATCCAGAAGGAGATCGACAGGCTGAACGAGGTGGCCA

AGAATCTGAACGAGTCCCTGATCGATCTGCAGGAGCTGGGCAAGTATGAGCA

GTACATCAAGTGGCCCTGGTATATCTGGCTGGGCTTCATCGCCGGCCTGATCG

CCATCGTGATGGTGACCATCATGCTGTGCTGTATGACAAGCTGCTGTTCCTGC CTGAAGGGCTGCTGTTCTTGTGGCAGCTGCTGTAAGTTTGATGAGGACGATAG

CGAGCCTGTGCTGAAGGGCGTGAAGCTGCACTACACCTGATAGCTAGCGATC

GCGTGCGAGAGGCCAGAACAACATCCGCCTACCATCCATCATTGTTATAAAA

AACTTAGGAACCAGGTCCACACAGCCGCCAGCCCATCAACCATCCACTCCCA

CGATTGGAGCC AAT GGC AGAAGAGC AGGC ACGCC AT GTC AAAAACGGACTG

GAATGCATCCGGGCTCTCAAGGCCGAGCCCATCGGCTCACTGGCCATCGAGG

AAGCT AT GGC AGC ATGGT C AGAAAT ATC AGAC AACCC AGGAC AGGAGCGAG

CCACCTGCAGGGAAGAGAAGGCAGGCAGTTCGGGTCTCAGCAAACCATGCCT

CTCAGCAATTGGATCAACTGAAGGCGGTGCACCTCGCATCCGCGGTCAGGGA

CCTGGAGAGAGCGAT GACGACGCTGAA ACTTT GGGAATCCCCCC AAGAAAT C

TCCAGGCATCAAGCACTGGGTTACAGTGTTATTACGTTTATGATCACAGCGGT

GA AGC GGTT A AGGGA AT C C A AG AT GCTGACTCT AT CAT GGTTC A AT C AGGC C

TTGATGGTGATAGCACCCTCTCAGGAGGAGACAATGAATCTGAAAACAGCGA

T GTGGAT ATTGGCGAACCTGAT ACCGAGGGAT AT GCT AT C ACTGACCGGGGA

TCTGCTCCCATCTCTATGGGGTTCAGGGCTTCTGATGTTGAAACTGCAGAAGG

AGGGGAGATCCACGAGCTCCTGAGACTCCAATCCAGAGGCAACAACTTTCCG

AAGCTTGGGAAAACTCTCAATGTTCCTCCGCCCCCGGACCCCGGTAGGGCCA

GCACTTCCGGGACACCCATTAAAAAGGGCACAGACGCGAGATTAGCCTCATT

T GGAACGGAGATCGCGTCTTT ATT GAC AGGTGGT GC AACCC AATGT GCTCGA

AAGTCACCCTCGGAACCATCAGGGCCAGGTGCACCTGCGGGGAATGTCCCCG

AGT GT GT G AGC A AT GC C GC AC T GAT AC AGG AGT GG AC AC C C G A AT C T GGT AC

CACAATCTCCCCGAGATCCCAGAATAATGAAGAAGGGGGAGACTATTATGAT

GATGAGCTGTTCTCTGATGTCCAAGATATTAAAACAGCCTTGGCCAAAATAC

ACGAGGATAATCAGAAGATAATCTCCAAGCTAGAATCACTGCTGTTATTGAA

GGGAGAAGTTGAGTCAATTAAGAAGCAGATCAACAGGCAAAATATCAGCAT

ATCCACCCTGGAAGGACACCTCTCAAGCATCATGATCGCCATTCCTGGACTTG

GGAAGGATCCCAACGACCCCACTGCAGATGTCGAAATCAATCCCGACTTGAA

ACCCATCATAGGCAGAGATTCAGGCCGAGCACTGGCCGAAGTTCTCAAGAAA

CCCGTTGCCAGCCGACAACTCCAAGGAATGACAAATGGACGGACCAGTTCCA

GAGGAC AGCTGCTGAAGGAATTTC AGCT AAAGCCGATCGGGAAAAAGATGA

GCTCAGCCGTCGGGTTTGTTCCTGACACCGGCCCTGCATCACGCAGTGTAATC

CGCTCCATTATAAAATCCAGCCGGCTAGAGGAGGATCGGAAGCGTTACCTGA

TGACTCTCCTTGATGATATCAAAGGAGCCAATGATCTTGCCAAGTTCCACCAG

ATGCTGATGAAGATAATAATGAAGTAGCTACAGCTCAACTTACCTGCCAACC CCATGCCAGTCGACCCACCTAGTACAACCTAAATCCATTATAAAAAACTTAG

GAGCAAAGTGATTGCCTCCCAAGGTCCACAATGACAGAGACCTACGACTTCG

ACAAGTCGGCATGGGACATCAAAGGGTCGATCGCTCCGATACAACCCACCAC

CTACAGTGATGGCAGGCTGGTGCCCCAGGTCAGAGTCATAGATCCTGGTCTA

GGC GAC AGGA AGGAT GA AT GC THAT GT AC AT GTTTCTGC T GGGGGTT GTT GA

GGACAGCGATTCCCTAGGGCCTCCAATCGGGCGAGCATTTGGGTTCCTGCCCT

TAGGTGTTGGCAGATCCACAGCAAAGCCCGAAAAACTCCTCAAAGAGGCCAC

T GAGCTT GAC AT AGTTGTT AGACGT AC AGC AGGGCTC AATGAAAAACTGGT G

TTCTACAACAACACCCCACTAACTCTCCTCACACCTTGGAGAAAGGTCCTAAC

AACAGGGAGTGTCTTCAACGCAAACCAAGTGTGCAATGCGGTTAATCTGATA

CCGCTCGATACCCCGCAGAGGTTCCGTGTTGTTTATATGAGCATCACCCGTCT

TTCGGAT AACGGGT ATT AC ACCGTTCCT AGAAGAAT GCTGGAATT C AGATCG

GTCAATGCAGTGGCCTTCAACCTGCTGGTGACCCTTAGGATTGACAAGGCGA

TAGGCCCTGGGAAGATCATCGACAATACAGAGCAACTTCCTGAGGCAACATT

T ATGGTCC AC ATCGGGAACTTC AGGAGAAAGAAGAGT GAAGTCT ACTCTGCC

GATT ATTGC AAAAT GAAAATCGAAAAGAT GGGCCTGGTTTTTGC ACTTGGT G

GGATAGGGGGCACCAGTCTTCACATTAGAAGCACAGGCAAAATGAGCAAGA

CTCTCCATGCACAACTCGGGTTCAAGAAGACCTTATGTTACCCGCTGATGGAT

ATCAATGAAGACCTTAATCGATTACTCTGGAGGAGCAGATGCAAGATAGTAA

GAATCCAGGCAGTTTTGCAGCCATCAGTTCCTCAAGAATTCCGCATTTACGAC

GACGTGATCATAAATGATGACCAAGGACTATTCAAAGTTCTGTAGACCGTAG

TGCCCAGCAATGCCCGAAAACGACCCCCCTCACAATGACAGCCAGAAGGCCC

GGACAAAAAAGCCCCCTCCGAAAGACTCCACGGACCAAGCGAGAGGCCAGC

CAGCAGCCGACGGCAAGCGCGAACACCAGGCGGCCCCAGCACAGAACAGCC

CTGACACAAGGCCACCACCAGCCACCCCAATCTGCATCCTCCTCGTGGGACC

CCCGAGGACCAACCCCCAAGGCTGCCCCCGATCCAAACCACCAACCGCATCC

CCACCACCCCCGGGAAAGAAACCCCCAGCAATTGGAAGGCCCCTCCCCCTCT

TCCTCAACACAAGAACTCCACAACCGAACCGCACAAGCGACCGAGGTGACCC

AACCGCAGGCATCCGACTCCCTAGACAGATCCTCTCTCCCCGGCAAACTAAA

CAAAACTTAGGGCCAAGGAACATACACACCCAACAGAACCCAGACCCCGGC

CCACGGCGCCGCGCCCCCAACCCCCGACAACCAGAGGGAGCCCCCAACCAAT

CCCGCCGGCTCCCCCGGTGCCCACAGGCAGGGACACCAACCCCCGAACAGAC

CCAGCACCCAACCATCGACAATCCAAGACGGGGGGGCCCCCCCAAAAAAAG

GCCCCCAGGGGCCGACAGCCAGCACCGCGAGGAAGCCCACCCACCCCACAC ACGACCACGGCAACCAAACCAGAACCCAGACCACCCTGGGCCACCAGCTCCC

AGACTCGGCCATCACCCCGCAGAAAGGAAAGGCCACAACCCGCGCACCCCA

GCCCCGATCCGGCGGGGAGCCACCCAACCCGAACCAGCACCCAAGAGCGATC

CCCGAAGGACCCCCGAACCGCAAAGGACATCAGTATCCCACAGCCTCTCCAA

GTCCCCCGGTCTCCTCCTCTTCTCGAAGGGACCAAAAGATCAATCCACCACAC

CCGACGACACTCAACTCCCCACCCCTAAAGGAGACACCGGGAATCCCAGAAT

CAAGACTCATCCAATGTCCATCATGGGTCTCAAGGTGAACGTCTCTGCCATAT

TCATGGCAGTACTGTTAACTCTCCAAACACCCACCGGTCAAATCCATTGGGGC

A ATCTCTCT A AGAT AGGGGT GGT AGGA AT AGGA AGT GC A AGC T AC A A AGTT A

TGACTCGTTCCAGCCATCAATCATTAGTCATAAAATTAATGCCCAATATAACT

CTCCTCAATAACTGCACGAGGGTAGAGATTGCAGAATACAGGAGACTACTGA

GAACAGTTTTGGAACCAATTAGAGATGCACTTAATGCAATGACCCAGAATAT

AAGACCGGTTCAGAGTGTAGCTTCAAGTAGGAGACACAAGAGATTTGCGGGA

GTAGTCCTGGCAGGTGCGGCCCTAGGCGTTGCCACAGCTGCTCAGATAACAG

CCGGCATTGCACTTCACCAGTCCATGCTGAACTCTCAAGCCATCGACAATCTG

AGAGCGAGCCTGGAAACTACTAATCAGGCAATTGAGACAATCAGACAAGCA

GGGCAGGAGATGATATTGGCTGTTCAGGGTGTCCAAGACTACATCAATAATG

AGCTGATACCGTCTATGAACCAACTATCTTGTGATTTAATCGGCCAGAAGCTC

GGGCTCAAATTGCTCAGATACTATACAGAAATCCTGTCATTATTTGGCCCCAG

TTTACGGGACCCCATATCTGCGGAGATATCTATCCAGGCTTTGAGCTATGCGC

TTGGAGGAGAC AT C AAT AAGGT GTT AGAAAAGCTCGGAT AC AGTGGAGGTGA

TTTACTGGGCATCTTAGAGAGCGGAGGAATAAAGGCCCGGATAACTCACGTC

GACACAGAGTCCTACTTCATTGTCCTCAGTATAGCCTATCCGACGCTGTCCGA

GATTAAGGGGGTGATTGTCCACCGGCTAGAGGGGGTCTCGTACAACATAGGC

TCTCAAGAGTGGTATACCACTGTGCCCAAGTATGTTGCAACCCAAGGGTACCT

TATCTCGAATTTTGATGAGTCATCGTGTACTTTCATGCCAGAGGGGACTGTGT

GCAGCCAAAATGCCTTGTACCCGATGAGTCCTCTGCTCCAAGAATGCCTCCGG

GGGTACACCAAGTCCTGTGCTCGTACACTCGTATCCGGGTCTTTTGGGAACCG

GTTCATTTTATCACAAGGGAACCTAATAGCCAATTGTGCATCAATCCTTTGCA

AGT GTT AC AC AAC AGGAACGAT C ATT AAT C AAGACCCTGAC AAGATCCT AAC

ATACATTGCTGCCGATCACTGCCCGGTAGTCGAGGTGAACGGCGTGACCATC

CAAGTCGGGAGCAGGAGGTATCCAGACGCTGTGTACTTGCACAGAATTGACC

TCGGTCCTCCCATATCATTGGAGAGGTTGGACGTAGGGACAAATCTGGGGAA

TGCAATTGCTAAGTTGGAGGATGCCAAGGAATTGTTGGAGTCATCGGACCAG ATATTGAGGAGTATGAAAGGTTTATCGAGCACTAGCATAGTCTACATCCTGAT

TGCAGTGTGTCTTGGAGGGTTGATAGGGATCCCCGCTTTAATATGTTGCTGCA

GGGGGC GTT GT A AC A A A A AGGGAGA AC A AGTT GGT AT GT C A AGACC AGGCC

TAAAGCCTGATCTTACGGGAACATCAAAATCCTATGTAAGGTCGCTCTGATCC

TCTACAACTCTTGAAACACAAATGTCCCACAAGTCTCCTCTTCGTCATCAAGC

AACCACCGCACCCAGCATCAAGCCCACCTGAAATTATCTCCGGCTTCCCTCTG

GCCGAACAATATCGGTAGTTAATTAAAACTTAGGGTGCAAGATCATCGATAA

TGTCACCACAACGAGACCGGATAAATGCCTTCTACAAAGATAACCCCCATCC

C AAGGGAAGT AGGAT AGT C ATT A AC AGAGAAC ATCTT AT GATT GAT AGACCT

TATGTTTTGCTGGCTGTTCTGTTTGTCATGTTTCTGAGCTTGATCGGGTTGCTA

GCCATTGCAGGAATTCGACTTCATCGGGCAGCCATCTACACCGCAGAGATCC

ATAAAAGCCTCAGCACCAATCTAGATGTAACTAACTCAATCGAGCATCAGGT

CAAGGACGTGCTGACACCACTCTTCAAAATCATCGGTGATGAAGTGGGCCTG

AGGAC ACC T C AGAGATT C AC T GAC CT AGT GA A ATT A AT C TC T G AC A AG ATT A

AATTCCTTAATCCGGATAGGGAGTACGACTTCAGAGATCTCACTTGGTGTATC

AACCCGCCAGAGAGAATCAAATTGGATTATGATCAATACTGTGCAGATGTGG

CTGCTGAAGAGCTCATGAATGCATTGGTGAACTCAACTCTACTGGAGACCAG

AACAACCAATCAGTTCCTAGCTGTCTCAAAGGGAAACTGCTCAGGGCCCACT

ACAATCAGAGGTCAATTCTCAAACATGTCGCTGTCCCTGTTAGACTTGTATTT

AGGTCGAGGTTACAATGTGTCATCTATAGTCACTATGACATCCCAGGGAATGT

AT GGGGGAACTT ACCT AGT GGAAAAGCCT AATCTGAGC AGC AAAAGGTC AGA

GTTGTCACAACTGAGCATGTACCGAGTGTTTGAAGTAGGTGTTATCAGAAATC

CGGGTTTGGGGGCTCCGGTGTTCCATATGACAAACTATCTTGAGCAACCAGTC

AGT AATGATCTC AGC AACTGT AT GGT GGCTTT GGGGGAGCTC AAACTCGC AG

CCCTTTGTCACGGGGAAGATTCTATCACAATTCCCTATCAGGGATCAGGGAA

AGGTGTCAGCTTCCAGCTCGTCAAGCTAGGTGTCTGGAAATCCCCAACCGAC

ATGCAATCCTGGGTCCCCTTATCAACGGATGATCCAGTGATAGACAGGCTTTA

CCTCTCATCTCACAGAGGTGTTATCGCTGACAACCAAGCAAAATGGGCTGTCC

CGAC AAC ACGAAC AGAT GAC AAGTT GCGAAT GG AG AC AT GCTTCC AAC AGGC

GTGTAAGGGTAAAATCCAAGCACTCTGCGAGAATCCCGAGTGGGCACCATTG

AAGGATAACAGGATTCCTTCATACGGGGTCTTGTCTGTTGATCTGAGTCTGAC

AGTTGAGCTTAAAATCAAAATTGCTTCGGGATTCGGGCCATTGATCACACAC

GGTTCAGGGATGGACCTATACAAATCCAACCACAACAATGTGTATTGGCTGA

CTATCCCGCCAATGAAGAACCTAGCCTTAGGTGTAATCAACACATTGGAGTG GATACCGAGATTCAAGGTTAGTCCCTACCTCTTCACTGTCCCAATTAAGGAAG

CAGGCGAAGACTGCCATGCCCCAACATACCTACCTGCGGAGGTGGATGGTGA

TGTCAAACTCAGTTCCAATCTGGTGATTCTACCTGGTCAAGATCTCCAATATG

TTTTGGCAACCTACGATACTTCCAGGGTTGAACATGCTGTGGTTTATTACGTTT

ACAGCCCAAGCCGCTCATTTTCTTACTTTTATCCTTTTAGGTTGCCTATAAAGG

GGGTCCCCATCGAATTACAAGTGGAATGCTTCACATGGGACCAAAAACTCTG

GTGCCGTCACTTCTGTGTGCTTGCGGACTCAGAATCTGGTGGACATATCACTC

ACTCTGGGATGGTGGGCATGGGAGTCAGCTGCACAGTCACCCGGGAAGATGG

AACCAATCGCAGATAGGGCTGCTAGTGAACCAATCACATGATGTCACCCAGA

CAT C AGGC AT ACCC ACT AGTGT GAAAT AGAC ATC AGAATT AAGAAA AACGT A

GGGTCCAAGTGGTTCCCCGTTATGGACTCGCTATCTGTCAACCAGATCTTATA

CCCTGAAGTTCACCTAGATAGCCCGATAGTTACCAATAAGATAGTAGCCATC

CTGGAGTATGCTCGAGTCCCTCACGCTTACAGCCTGGAGGACCCTACACTGTG

TCAGAACATCAAGCACCGCCTAAAAAACGGATTTTCCAACCAAATGATTATA

AACAATGTGGAAGTTGGGAATGTCATCAAGTCCAAGCTTAGGAGTTATCCGG

CCCACTCTCATATTCCATATCCAAATTGTAATCAGGATTTATTTAACATAGAA

GACAAAGAGTCAACGAGGAAGATCCGTGAACTCCTCAAAAAGGGGAATTCG

CTGTACTCCAAAGTCAGTGATAAGGTTTTCCAATGCTTAAGGGACACTAACTC

ACGGCTT GGCCT AGGCTCCGAATT GAGGGAGGAC AT C AAGGAGA AAGTT ATT

AACTTGGGAGTTTACATGCACAGCTCCCAGTGGTTTGAGCCCTTTCTGTTTTG

GTTTACAGTCAAGACTGAGATGAGGTCAGTGATTAAATCACAAACCCATACT

TGCCATAGGAGGAGACACACACCTGTATTCTTCACTGGTAGTTCAGTTGAGTT

GCTAATCTCTCGTGACCTTGTTGCTATAATCAGTAAAGAGTCTCAACATGTAT

ATTACCTGACATTTGAACTGGTTTTGATGTATTGTGATGTCATAGAGGGGAGG

TTAATGACAGAGACCGCTATGACTATTGATGCTAGGTATACAGAGCTTCTAG

GAAGAGTCAGATACATGTGGAAACTGATAGATGGTTTCTTCCCTGCACTCGG

GAATCCAACTTATCAAATTGTAGCCATGCTGGAGCCTCTTTCACTTGCTTACC

T GC AGCTGAGGGAT AT AAC AGT AGAACTC AGAGGT GCTTTCCTT AACC ACTG

CTTTACTGAAATACATGATGTTCTTGACCAAAACGGGTTTTCTGATGAAGGTA

CTTATCATGAGTTAACTGAAGCTCTAGATTACATTTTCATAACTGATGACATA

CATCTGACAGGGGAGATTTTCTCATTTTTCAGAAGTTTCGGCCACCCCAGACT

T GA AGC AGT A ACGGC T GC T GA A A AT GTT AGGA A AT AC AT GA AT C AGCC T AAA

GTCATTGTGTATGAGACTCTGATGAAAGGTCATGCCATATTTTGTGGAATCAT

AATCAACGGCTATCGTGACAGGCACGGAGGCAGTTGGCCACCGCTGACCCTC CCCCTGCATGCTGCAGACACAATCCGGAATGCTCAAGCTTCAGGTGAAGGGT

TAACACATGAGCAGTGCGTTGATAACTGGAAATCTTTTGCTGGAGTGAAATTT

GGCTGCTTTATGCCTCTTAGCCTGGATAGTGATCTGACAATGTACCTAAAGGA

CAAGGCACTTGCTGCTCTCCAAAGGGAATGGGATTCAGTTTACCCGAAAGAG

TTCCTGCGTTACGACCCTCCCAAGGGAACCGGGTCACGGAGGCTTGTAGATG

TTTTCCTTAATGATTCGAGCTTTGACCCATATGATGTGATAATGTATGTTGTAA

GTGGAGCTTACCTCCATGACCCTGAGTTCAACCTGTCTTACAGCCTGAAAGAA

AAGGAGATC A AGGAAAC AGGT AGACTTTTT GCT AAAAT GACTT AC AAAAT GA

GGGCATGCCAAGTGATTGCTGAAAATCTAATCTCAAACGGGATTGGCAAATA

TTTT AAGGAC AAT GGGAT GGCC AAGGAT GAGC ACGATTT GACT AAGGC ACTC

CACACTCTAGCTGTCTCAGGAGTCCCCAAAGATCTCAAAGAAAGTCACAGGG

GGGGGCCAGTCTTAAAAACCTACTCCCGAAGCCCAGTCCACACAAGTACCAG

GAACGTGAGAGCAGCAAAAGGGTTTATAGGGTTCCCTCAAGTAATTCGGCAG

GACCAAGACACTGATCATCCGGAGAATATGGAAGCTTACGAGACAGTCAGTG

C ATTT AT C ACGACTGATCTC AAGAAGT ACTGCCTT AATT GGAGAT ATGAGACC

ATCAGCTTGTTTGCACAGAGGCTAAATGAGATTTACGGATTGCCCTCATTTTT

CCAGTGGCTGCATAAGAGGCTTGAGACCTCTGTCCTGTATGTAAGTGACCCTC

ATTGCCCCCCCGACCTTGACGCCCATATCCCGTTATATAAAGTCCCCAATGAT

C AAATCTTC ATT AAGT ACCCT AT GGGAGGT AT AGAAGGGT ATT GTC AGAAGC

TGTGGACCATCAGCACCATTCCCTATCTATACCTGGCTGCTTATGAGAGCGGA

GTAAGGATTGCTTCGTTAGTGCAAGGGGACAATCAGACCATAGCCGTAACAA

AAAGGGTACCCAGCACATGGCCCTACAACCTTAAGAAACGGGAAGCTGCTAG

AGT AACT AGAGATT ACTTT GT AATTCTT AGGC AAAGGCT AC AT GAT ATTGGCC

ATCACCTCAAGGCAAATGAGACAATTGTTTCATCACATTTTTTTGTCTATTCA

A A AGGA AT AT ATT AT GAT GGGC T AC TT GT GT C CCA AT C AC TC A AGAGC ATCG

C AAGAT GT GT ATTCTGGTC AGAGACT AT AGTT GAT GAAAC AAGGGC AGC ATG

CAGTAATATTGCTACAACAATGGCTAAAAGCATCGAGAGAGGTTATGACCGT

TACCTTGCATATTCCCTGAACGTCCTAAAAGTGATACAGCAAATTCTGATCTC

TCTTGGCTTCACAATCAATTCAACCATGACCCGGGATGTAGTCATACCCCTCC

TCACAAACAACGACCTCTTAATAAGGATGGCACTGTTGCCCGCTCCTATTGGG

GGGAT G A ATT AT C T G A AT AT GAGC AGGC T GT TT GT C AG A A AC ATC GGT GAT C

CAGTAACATCATCAATTGCTGATCTCAAGAGAATGATTCTCGCCTCACTAATG

CCTGAAGAGACCCTCCATCAGGTAATGACACAACAACCGGGGGACTCTTCAT

TCCTAGACTGGGCTAGCGACCCTTACTCAGCAAATCTTGTATGTGTCCAGAGC ATCACTAGACTCCTCAAGAACATAACTGCAAGGTTTGTCCTGATCCATAGTCC

AAACCC AAT GTT AAAAGGATT ATTCC AT GATGAC AGT A A AG A AG AGG AC GAG

GGACTGGCGGCATTCCTCATGGACAGGCATATTATAGTACCTAGGGCAGCTC

ATGAAATCCTGGATCATAGTGTCACAGGGGCAAGAGAGTCTATTGCAGGCAT

GCTGGAT ACC AC AAAAGGCTT GATTCGAGCC AGC AT GAGGAAGGGGGGTTT A

ACCTCTCGAGTGATAACCAGATTGTCCAATTATGACTATGAACAATTCAGAGC

AGGGAT GGT GCT ATT GAC AGGAAGAA AGAGAAAT GTCCTC ATTGAC AAAGA

GT CAT GTT C AGT GC AGC T GGCGAGAGC TCT A AGA AGCC AT AT GT GGGC GAGG

CTAGCTCGAGGACGGCCTATTTACGGCCTTGAGGTCCCTGATGTACTAGAATC

TATGCGAGGCCACCTTATTCGGCGTCATGAGACATGTGTCATCTGCGAGTGTG

GATCAGTCAACTACGGATGGTTTTTTGTCCCCTCGGGTTGCCAACTGGATGAT

ATTGAC AAGGAAACATCATCCTTGAGAGTCCCATATATTGGTTCTACCACTGA

TGAGAGAACAGACATGAAGCTTGCCTTCGTAAGAGCCCCAAGTCGATCCTTG

CGATCTGCTGTTAGAATAGCAACAGTGTACTCATGGGCTTACGGTGATGATG

ATAGCTCTTGGAACGAAGCCTGGTTGTTGGCTAGGCAAAGGGCCAATGTGAG

CCTGGAGGAGCTAAGGGTGATCACTCCCATCTCAACTTCGACTAATTTAGCGC

AT AGGTT GAGGGATCGT AGC ACTC AAGT GAAAT ACTC AGGT AC ATCCCTTGT

CCGAGTGGCGAGGTATACCACAATCTCCAACGACAATCTCTCATTTGTCATAT

C AGAT A AGA AGGTTGAT AC T A AC TTT AT AT AC C A AC A AGG A AT GC TTCT AGG

GTTGGGTGTTTTAGAAACATTGTTTCGACTCGAGAAAGATACCGGATCATCTA

ACACGGTATTACATCTTCACGTCGAAACAGATTGTTGCGTGATCCCGATGATA

GATCATCCCAGGATACCCAGCTCCCGCAAGCTAGAGCTGAGGGCAGAGCTAT

GTACCAACCCATTGATATATGATAATGCACCTTTAATTGACAGAGATGCAAC

AAGGCTATACACCCAGAGCCATAGGAGGCACCTTGTGGAATTTGTTACATGG

TCCACACCCCAACTATATCACATTTTAGCTAAGTCCACAGCACTATCTATGAT

TGACCTGGTAACAAAATTTGAGAAGGACCATATGAATGAAATTTCAGCTCTC

ATAGGGGATGACGATATCAATAGTTTCATAACTGAGTTTCTGCTCATAGAGCC

AAGATTATTCACTATCTACTTGGGCCAGTGTGCGGCCATCAATTGGGCATTTG

ATGTACATTATCATAGACCATCAGGGAAATATCAGATGGGTGAGCTGTTGTC

ATCGTTCCTTTCTAGAATGAGCAAAGGAGTGTTTAAGGTGCTTGTCAATGCTC

TAAGCCACCCAAAGATCTACAAGAAATTCTGGCATTGTGGTATTATAGAGCC

TATCCATGGTCCTTCACTTGATGCTCAAAACTTGCACACAACTGTGTGCAACA

TGGTTTACACATGCTATATGACCTACCTCGACCTGTTGTTGAATGAAGAGTTA

GAAGAGTTCACATTTCTCTTGTGTGAAAGCGACGAGGATGTAGTACCGGACA GATTCGACAACATCCAGGCAAAACACTTATGTGTTCTGGCAGATTTGTACTGT

C A AC C AGGGAC CTGCC C AC C A ATTC GAGGT C T A AGACC GGT AGAGA A AT GT G

CAGTTCTAACCGACCATATCAAGGCAGAGGCTATGTTATCTCCAGCAGGATCT

TCGTGGAACATAAATCCAATTATTGTAGACCATTACTCATGCTCCCTGACTTA

TCTCCGGCGAGGATCGATCAAACAGATAAGATTGAGAGTTGATCCAGGATTC

ATTTTCGACGCCCTCGCTGAGGTAAATGTCAGTCAGCCAAAGATCGGCAGCA

ACAACATCTCAAATATGAGCATCAAGGCTTTCAGACCCCCACACGATGATGT

TGCAAAATTGCTCAAAGATATCAACACAAGCAAGCACAATCTTCCCATTTCA

GGGGGCAATCTCGCCAATTATGAAATCCATGCTTTCCGCAGAATCGGGTTGA

ACTC ATCTGCTTGCT AC AAAGCTGTT GAG AT AT C AAC ATT AATT AGGAGAT GC

CTTGAGCC AGGGGAGGACGGCTT GTTCTTGGGT GAGGGATCGGGTTCT AT GTT

GAT C ACTT AT AAGGAGAT ACTT AAACT AAAC AAGT GCTTCT AT AAT AGT GGG

GTTTCCGCCAATTCTAGATCTGGTCAAAGGGAATTAGCACCCTATCCCTCCGA

AGTTGGCCTTGTCGAACACAGAATGGGAGTAGGTAATATTGTCAAAGTGCTC

TTTAACGGGAGGCCCGAAGTCACGTGGGTAGGCAGTGTAGATTGCTTCAATT

TCATAGTTAGTAATATCCCTACCTCTAGTGTGGGGTTTATCCATTCAGATATA

GAGACCTTGCCTGAC AAAGAT ACT AT AGAGAAGCT AGAGGAATTGGC AGCC A

TCTT ATCGAT GGCTCTGCTCCTGGGC A AAAT AGGAT C AAT ACTGGT GATT AAG

CTTATGCCTTTCAGCGGGGATTTTGTTCAGGGATTTATAAGTTATGTAGGGTC

TCATTATAGAGAAGTGAACCTTGTATACCCTAGATACAGCAACTTCATATCTA

CTGAATCTTATTTGGTTATGACAGATCTCAAGGCTAACCGGCTAATGAATCCT

GAAAAGATT AAGC AGC AGAT AATT GAAT C ATCTGTGAGGACTTC ACCTGGAC

TTATAGGTCACATCCTATCCATTAAGCAACTAAGCTGCATACAAGCAATTGTG

GGAGACGC AGTT AGT AGAGGT GAT ATC A ATCCT ACTCTGAAAAAACTT AC AC

CTATAGAGCAGGTGCTGATCAATTGCGGGTTGGCAATTAACGGACCTAAGCT

GTGCAAAGAATTGATCCACCATGATGTTGCCTCAGGGCAAGATGGATTGCTT

AATTCTATACTCATCCTCTACAGGGAGTTGGCAAGATTCAAAGACAACCAAA

GAAGT C AAC AAGGGAT GTTCC ACGCCT ACCCCGT ATTGGT AAGT AGC AGGC A

ACGAGAACTTATATCTAGGATCACCCGCAAATTTTGGGGGCACATTCTTCTTT

ACTCCGGGAAC AAA AAGTTGAT AAAT AAGTTT ATCC AGAATCTC AAGTCCGG

CTATCTGATACTAGACTTACACCAGAATATCTTCGTTAAGAATCTATCCAAGT

C AGAGAAAC AGATT ATT ATGACGGGGGGTTT GAAACGT GAGT GGGTTTTT AA

GGT A AC AGT C A AGG AG AC C A A AG A AT GGT AT A AGTT AGT C GG AT AC AGT GC C

CTGATTAAGGACTAATTGGTTGAACTCCGGAACCCTAATCCTGCCCTAGGTGG TTAGGCATTATTTGCAATATATTAAAGAAAACTTTGAAAATACGAAGTTTCTA

TTCCCAGCTTTGTCTGGTggccggcatAgtcccagcctcctcgctggcgctggctgggcaacattccgaggg gaccgtccccAcggtaatggcgaatgggacgcggccgatccggctgctaacaaagcccgaaaggaagctgagttggctgct gGcGcTGgctgGgcaataactagcataaccccttggggcctctaaacgggtcttgaggggttttttgctgaaaggaggaact atatccggatgcGGCCGCGCGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGA

AATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGT

GT AAAGCCTGGGGT GCCT AAT GAGT GAGCT AACTC AC ATT AATT GCGTT GCG

CTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAA

TCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCC

TCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGC

TC AC T C A A AGGC GGT AAT AC GGTT ATC C AC AG A AT C AGGGG AT A AC GC AGG A

A AG A AC AT GT G AGC A A A AGGC C AGC A A A AGGC C AGG A AC C GT A A A A AGGC C

GCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAA

TCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAG

GCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTT

ACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAG

CTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCT

GTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTAT

CGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCA

CTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTT

GAAGTGGTGGCCTAACTACGGCTACACTAGAAGGACAGTATTTGGTATCTGC

GCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGG

CAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTA

CGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTC

T GACGCTC AGT GGAACGAAAACTC ACGTT AAGGGATTTTGGT CAT GAG ATT A

TCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATC

AATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCA

GTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGA

CTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCA

GTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGC

AAT AAACC AGCC AGCCGGAAGGGCCGAGCGC AGAAGT GGTCCTGC A ACTTT A

TCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTC

GCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGT

CACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGG CGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCC

TCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGG

CAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTG

ACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGA

GTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAAC

TTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGG

ATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTG

ATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAA

GGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATAC

TCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCA

TGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCC

GCGCACATTTCCCCGAAAAGTGCCACCTG.

In another embodiment, the nucleic acid comprises the sequence of SEQ ID NO:

4, shown below:

GGACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGC

AGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTT

CCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGG

GGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAA

CTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTT

TCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAA

CTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATT

TTGCCGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAA

CGCGAATTTTAACAAAATATTAACGTTTACAATTTCGCGCCATTCGCCATTCA

GGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACG

CCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCA

GGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAGTGCGCGCCGTTAAT

ACGACTCACTATAGGGAGACCCAAGCTGGCTAGCTTTGTTTGGTCTGATGAGT

CCCGTGAGGACGAAACCCGGCGTACCGGGTCACCAAACAAAGTTGGGTAAG

GATAGTTCAATCAATGATCATCTTCTAGTGCACTTAGGATTCAAGATCCTATT

AT C AGGGAC AAGAGC AGGATT AGGGAT ATCCGAGAT GGCC AC ACTTTT A AGG

AGCTTAGCATTGTTCAAAAGAAACAAGGACAAACCACCCATTACATCAGGAT

CCGGTGGAGCCATCAGAGGAATCAAACACATTATTATAGTACCAATCCCTGG

AGATTCCTCAATTACCACTCGATCCAGACTTCTGGACCGGTTGGTGAGGTTAA

TTGGAAACCCGGATGTGAGCGGGCCCAAACTAACAGGGGCACTAATAGGTAT ATTATCCTTATTTGTGGAGTCTCCAGGTCAATTGATTCAGAGGATCACCGATG

ACCCTGACGTTAGCATAAGGCTGTTAGAGGTTGTCCAGAGTGACCAGTCACA

ATCTGGCCTTACCTTCGCATCAAGAGGTACCAACATGGAGGATGAGGCGGAC

CAATACTTTTCACATGATGATCCAATTAGTAGTGATCAATCCAGGTTCGGATG

GTTCGGGAAC AAGGAAATCTC AGAT ATTGAAGT GC AAGACCCTGAGGGATT C

AACATGATTCTGGGTACCATCCTAGCCCAAATTTGGGTCTTGCTCGCAAAGGC

GGTTACGGCCCCAGACACGGCAGCTGATTCGGAGCTAAGAAGGTGGATAAAG

TACACCCAACAAAGAAGGGTAGTTGGTGAATTTAGATTGGAGAGAAAATGGT

TGGATGTGGTGAGGAACAGGATTGCCGAGGACCTCTCCTTACGCCGATTCAT

GGTCGCTCTAATCCTGGATATCAAGAGAACACCCGGAAACAAACCCAGGATT

GCTGAAAT GAT ATGT GAC ATTGAT AC AT AT ATCGT AGAGGC AGGATT AGCC A

GTTTTATCCTGACTATTAAGTTTGGGATAGAAACTATGTATCCTGCTCTTGGA

CTGCATGAATTTGCTGGTGAGTTATCCACACTTGAGTCCTTGATGAACCTTTA

CCAGCAAATGGGGGAAACTGCACCCTACATGGTAATCCTGGAGAACTCAATT

CAGAACAAGTTCAGTGCAGGATCATACCCTCTGCTCTGGAGCTATGCCATGG

GAGT AGGAGT GGAACTTGAAAACTCC AT GGGAGGTTT GAACTTT GGCCGATC

TTACTTTGATCCAGCATATTTTAGATTAGGGCAAGAGATGGTAAGGAGGTCA

GCTGGAAAGGT C AGTTCC AC ATT GGC ATCTGAACTCGGT AT C ACTGCCGAGG

AT GC AAGGCTT GTTTC AGAGATTGC AAT GC AT ACT ACTGAGGAC A AGATC AG

TAGAGCGGTTGGACCCAGACAAGCCCAAGTATCATTTCTACACGGTGATCAA

AGTGAGAATGAGCTACCGAGATTGGGGGGCAAGGAAGATAGGAGGGTCAAA

C AGAGT C GAGGAGA AGC C AGGGAGAGCT AC AGAGA A ACC GGGCC C AGC AGA

GCAAGTGATGCGAGAGCTGCCCATCTTCCAACCGGCACACCCCTAGACATTG

ACACTGCAACGGAGTCCAGCCAAGATCCGCAGGACAGTCGAAGGTCAGCTGA

CGCCCTGCTT AGGCTGC AAGCC AT GGC AGGAATCTCGGAAGAAC AAGGCTC A

GACACGGACACCCCTATAGTGTACAATGACAGAAATCTTCTAGACTAGGTGC

GAGAGGCCGAGGGCCAGAACAACATCCGCCTACCATCCATCATTGTTATAAA

AAACTTAGGAACCAGGTCCACACAGCCGCCAGCCCATCAACCATCCACTCCC

ACGATTGGAGCCAATGGCAGAAGAGCAGGCACGCCATGTCAAAAACGGACT

GGAATGCATCCGGGCTCTCAAGGCCGAGCCCATCGGCTCACTGGCCATCGAG

GA AGC TAT GGC AGC AT GGTC AGA A AT AT C AGAC A AC CC AGGAC AGGAGC GA

GCCACCTGCAGGGAAGAGAAGGCAGGCAGTTCGGGTCTCAGCAAACCATGCC

TCTCAGCAATTGGATCAACTGAAGGCGGTGCACCTCGCATCCGCGGTCAGGG

ACCTGGAGAGAGCGATGACGACGCTGAAACTTTGGGAATCCCCCCAAGAAAT CTCCAGGCATCAAGCACTGGGTTACAGTGTTATTACGTTTATGATCACAGCGG

TGAAGCGGTTAAGGGAATCCAAGATGCTGACTCTATCATGGTTCAATCAGGC

CTTGATGGT GAT AGC ACCCTCTC AGGAGGAGAC AAT GAATCTGAAAAC AGCG

ATGTGGATATTGGCGAACCTGATACCGAGGGATATGCTATCACTGACCGGGG

ATCTGCTCCCATCTCTATGGGGTTCAGGGCTTCTGATGTTGAAACTGCAGAAG

GAGGGGAGATCCACGAGCTCCTGAGACTCCAATCCAGAGGCAACAACTTTCC

GAAGCTTGGGAAAACTCTCAATGTTCCTCCGCCCCCGGACCCCGGTAGGGCC

AGCACTTCCGGGACACCCATTAAAAAGGGCACAGACGCGAGATTAGCCTCAT

TTGGAACGGAGATCGCGTCTTTATTGACAGGTGGTGCAACCCAATGTGCTCG

AAAGTCACCCTCGGAACCATCAGGGCCAGGTGCACCTGCGGGGAATGTCCCC

GAGTGTGTGAGCAATGCCGCACTGATACAGGAGTGGACACCCGAATCTGGTA

CCACAATCTCCCCGAGATCCCAGAATAATGAAGAAGGGGGAGACTATTATGA

TGATGAGCTGTTCTCTGATGTCCAAGATATTAAAACAGCCTTGGCCAAAATAC

ACGAGGATAATCAGAAGATAATCTCCAAGCTAGAATCACTGCTGTTATTGAA

GGGAGAAGTTGAGTCAATTAAGAAGCAGATCAACAGGCAAAATATCAGCAT

ATCCACCCTGGAAGGACACCTCTCAAGCATCATGATCGCCATTCCTGGACTTG

GGAAGGATCCCAACGACCCCACTGCAGATGTCGAAATCAATCCCGACTTGAA

ACCCATCATAGGCAGAGATTCAGGCCGAGCACTGGCCGAAGTTCTCAAGAAA

CCCGTTGCCAGCCGACAACTCCAAGGAATGACAAATGGACGGACCAGTTCCA

GAGGAC AGCTGCTGAAGGAATTTC AGCT AAAGCCGATCGGGAAAAAGATGA

GCTCAGCCGTCGGGTTTGTTCCTGACACCGGCCCTGCATCACGCAGTGTAATC

CGCTCCATTATAAAATCCAGCCGGCTAGAGGAGGATCGGAAGCGTTACCTGA

TGACTCTCCTTGATGATATCAAAGGAGCCAATGATCTTGCCAAGTTCCACCAG

ATGCTGATGAAGATAATAATGAAGTAGCTACAGCTCAACTTACCTGCCAACC

CCATGCCAGTCGATCATCCATCATTGTTATAAAAAACTTAGGAACCAggtccacac aGagtgatACGCGTACGCCACCATGTTCGTGTTTCTGGTGCTGCTGCCTCTGGTGA

GCTCCCAGTGCGTGAACCTGACCACAAGGACCCAGCTGCCCCCTGCCTATAC

CAATTCCTTCACACGGGGCGTGTACTATCCCGACAAGGTGTTCCGGAGCAGC

GTGCTGCACTCCACACAGGATCTGTTTCTGCCTTTCTTTTCTAACGTGACCTGG

TTCCACGCCATCCACGTGAGCGGCACCAATGGCACAAAGCGGTTCGACAATC

CAGTGCTGCCCTTTAACGATGGCGTGTACTTCGCCTCCACCGAGAAGTCTAAC

ATCATCAGAGGCTGGATCTTTGGCACCACACTGGACAGCAAGACACAGTCCC

TGCTGATCGTGAACAATGCCACCAACGTGGTCATCAAGGTGTGCGAGTTCCA

GTTTTGTAATGATCCATTCCTGGGCGTGTACTATCACAAGAACAATAAGTCTT GGATGGAGAGCGAGTTTCGCGTGTATTCCTCTGCCAACAATTGCACATTTGAG

TACGTGTCCCAGCCCTTCCTGATGGACCTGGAGGGCAAGCAGGGCAATTTCA

AGAACCTGAGGGAGTTCGTGTTTAAGAATATCGATGGCTACTTCAAAATCTA

CTCCAAGCACACCCCAATCAACCTGGTGCGCGACCTGCCACAGGGCTTCTCTG

CCCTGGAGCCACTGGTGGATCTGCCCATCGGCATCAACATCACCCGGTTTCAG

ACACTGCTGGCCCTGCACAGAAGCTACCTGACACCAGGCGACAGCTCCTCTG

GATGGACCGCAGGAGCAGCAGCCTACTATGTGGGCTATCTGCAGCCCAGGAC

CTTCCTGCTGAAGTACAACGAGAATGGCACCATCACAGACGCCGTGGATTGC

GCCCTGGATCCCCTGTCTGAGACCAAGTGTACACTGAAGAGCTTTACCGTGG

AGAAGGGCATCTATCAGACAAGCAATTTCAGGGTGCAGCCTACCGAGTCCAT

CGTGCGCTTTCCCAATATCACAAACCTGTGCCCTTTTGGCGAGGTGTTCAACG

CAACCCGCTTCGCCAGCGTGTACGCCTGGAATAGGAAGCGCATCTCCAACTG

CGTGGCCGACTATTCTGTGCTGTACAACAGCGCCTCCTTCTCTACCTTTAAGT

GCTATGGCGTGAGCCCCACAAAGCTGAATGACCTGTGCTTTACCAACGTGTA

CGCCGATTCCTTCGTGATCAGGGGCGACGAGGTGCGCCAGATCGCACCAGGA

CAGACAGGCAAGATCGCAGACTACAATTATAAGCTGCCTGACGATTTCACCG

GCTGCGT GATCGCCTGGAACTCT AAC AATCTGGAT AGC AAAGT GGGCGGC AA

CTACAATTATCTGTACCGGCTGTTTAGAAAGTCTAATCTGAAGCCATTCGAGA

GGGACATCTCCACAGAAATCTACCAGGCCGGCTCTACCCCCTGCAATGGCGT

GGAGGGCTTTAACTGTTATTTCCCTCTGCAGAGCTACGGCTTCCAGCCAACAA

ACGGCGTGGGCTATCAGCCCTACCGCGTGGTGGTGCTGTCTTTTGAGCTGCTG

C ACGC ACCTGC AAC AGTGT GCGGACC AAAGAAGAGC ACC AATCTGGT GAAG

AACAAGTGCGTGAACTTCAACTTCAACGGACTGACCGGAACAGGCGTGCTGA

CCGAGTCCAACAAGAAGTTCCTGCCTTTTCAGCAGTTCGGCAGGGACATCGC

AGATACCACAGACGCCGTGCGCGACCCTCAGACCCTGGAGATCCTGGACATC

ACACCATGCTCCTTCGGCGGCGTGTCTGTGATCACACCAGGCACCAATACAA

GCAACCAGGTGGCCGTGCTGTATCAGGACGTGAATTGTACCGAGGTGCCAGT

GGCAATCCACGCAGATCAGCTGACCCCTACATGGCGGGTGTACTCTACCGGC

AGC AAC GT GTTCC AGAC AAGAGCCGGAT GCCTGATCGGAGC AGAGC ACGTGA

ACAATAGCTATGAGTGCGACATCCCTATCGGCGCCGGCATCTGTGCCTCCTAC

CAGACCCAGACAAACTCCCCAAGGAGAGCACGGTCTGTGGCCAGCCAGTCCA

TCATCGCCTATACCATGAGCCTGGGCGCCGAGAATTCCGTGGCCTACTCCAAC

AATTCTATCGCCATCCCTACCAACTTCACAATCTCCGTGACCACAGAGATCCT

GCC AGT GAGC AT GACC AAGAC ATCCGTGGACTGC AC AATGT AT ATCTGT GGC GATTCCACCGAGTGCTCTAACCTGCTGCTGCAGTACGGCTCTTTTTGTACCCA

GCTGAAT AGAGCCCTGAC AGGC ATCGCCGT GGAGC AGGAC AAGAAC AC AC A

GGAGGTGTTCGCCCAGGTGAAGCAAATCTACAAGACCCCACCCATCAAGGAC

TTTGGCGGCTTCAACTTCAGCCAGATCCTGCCCGATCCTAGCAAGCCATCCAA

GCGGTCTTTTATCGAGGACCTGCTGTTCAACAAGGTGACCCTGGCCGATGCCG

GCTTCATCAAGCAGTATGGCGATTGCCTGGGCGACATCGCCGCCAGAGACCT

GATCTGTGCCCAGAAGTTTAATGGCCTGACCGTGCTGCCTCCACTGCTGACAG

ATGAGATGATCGCCCAGTACACATCTGCCCTGCTGGCCGGAACCATCACAAG

CGGATGGACCTTCGGCGCAGGAGCCGCCCTGCAGATCCCCTTTGCCATGCAG

ATGGCCTATCGGTTCAACGGCATCGGCGTGACCCAGAATGTGCTGTACGAGA

ACCAGAAGCTGATCGCCAATCAGTTTAACTCCGCCATCGGCAAGATCCAGGA

CTCTCTGAGCTCCACAGCCAGCGCCCTGGGCAAGCTGCAGGATGTGGTGAAT

CAGAACGCCCAGGCCCTGAATACCCTGGTGAAGCAGCTGTCTAGCAACTTCG

GCGCCATCTCCTCTGTGCTGAATGACATCCTGAGCCGGCTGGACAAGGTGGA

GGCAGAGGTGCAGATCGACCGGCTGATCACAGGCAGACTGCAGTCCCTGCAG

ACCTACGTGACACAGCAGCTGATCAGGGCAGCAGAGATCAGGGCCTCTGCCA

ATCTGGCCGCCACCAAGATGAGCGAGTGCGTGCTGGGCCAGTCCAAGAGAGT

GGACTTTTGTGGCAAGGGCTATCACCTGATGAGCTTCCCACAGTCCGCCCCTC

ACGGAGTGGTGTTTCTGCACGTGACCTACGTGCCAGCCCAGGAGAAGAACTT

CACCACAGCACCAGCAATCTGCCACGATGGCAAGGCACACTTTCCTAGGGAG

GGCGTGTTCGTGAGCAACGGCACCCACTGGTTTGTGACACAGCGCAATTTCTA

CGAGCCACAGATCATCACCACAGACAATACATTCGTGTCCGGCAACTGTGAC

GTGGTCATCGGCATCGTGAACAATACCGTGTATGATCCTCTGCAGCCAGAGCT

GGACTCTTTTAAGGAGGAGCTGGATAAGTACTTCAAGAATCACACCAGCCCC

GACGTGGATCTGGGCGACATCTCTGGCATCAATGCCAGCGTGGTGAACATCC

AGAAGGAGATCGACAGGCTGAACGAGGTGGCCAAGAATCTGAACGAGTCCC

TGATCGATCTGCAGGAGCTGGGCAAGTATGAGCAGTACATCAAGTGGCCCTG

GTATATCTGGCTGGGCTTCATCGCCGGCCTGATCGCCATCGTGATGGTGACCA

TCATGCTGTGCTGTATGACAAGCTGCTGTTCCTGCCTGAAGGGCTGCTGTTCT

TGTGGCAGCTGCTGTAAGTTTGATGAGGACGATAGCGAGCCTGTGCTGAAGG

GCGTGAAGCTGCACTACACCTGATAGCTAGCGATCGCCCACCTAGTACAACC

T AAATCC ATT AT AAAAAACTT AGGAGC AAAGTGATTGCCTCCC AAGGTCC AC

AATGACAGAGACCTACGACTTCGACAAGTCGGCATGGGACATCAAAGGGTCG

ATCGCTCCGATACAACCCACCACCTACAGTGATGGCAGGCTGGTGCCCCAGG TC AGAGT CAT AG AT C CTGGT C T AGGC GAC AGGA AGGAT GA AT GC THAT GT A

CATGTTTCTGCTGGGGGTTGTTGAGGACAGCGATTCCCTAGGGCCTCCAATCG

GGCGAGCATTTGGGTTCCTGCCCTTAGGTGTTGGCAGATCCACAGCAAAGCC

CGAAAAACTCCTCAAAGAGGCCACTGAGCTTGACATAGTTGTTAGACGTACA

GCAGGGCTCAATGAAAAACTGGTGTTCTACAACAACACCCCACTAACTCTCC

TCACACCTTGGAGAAAGGTCCTAACAACAGGGAGTGTCTTCAACGCAAACCA

AGTGTGCAATGCGGTTAATCTGATACCGCTCGATACCCCGCAGAGGTTCCGTG

TTGTTTATATGAGCATCACCCGTCTTTCGGATAACGGGTATTACACCGTTCCT

AGAAGAAT GCTGGAATTC AGATCGGT C AATGC AGT GGCCTT C AACCTGCTGG

TGACCCTTAGGATTGACAAGGCGATAGGCCCTGGGAAGATCATCGACAATAC

AGAGCAACTTCCTGAGGCAACATTTATGGTCCACATCGGGAACTTCAGGAGA

AAGAAGAGT GAAGTCT ACTCTGCCGATT ATT GC A AAATGA AAATCGAAAAGA

TGGGCCTGGTTTTTGCACTTGGTGGGATAGGGGGCACCAGTCTTCACATTAGA

AGCACAGGCAAAATGAGCAAGACTCTCCATGCACAACTCGGGTTCAAGAAGA

CCTTATGTTACCCGCTGATGGATATCAATGAAGACCTTAATCGATTACTCTGG

AGGAGC AGAT GC AAGAT AGT AAGAATCC AGGC AGTTTTGC AGCC AT C AGTTC

CTCAAGAATTCCGCATTTACGACGACGTGATCATAAATGATGACCAAGGACT

ATTCAAAGTTCTGTAGACCGTAGTGCCCAGCAATGCCCGAAAACGACCCCCC

TCACAATGACAGCCAGAAGGCCCGGACAAAAAAGCCCCCTCCGAAAGACTCC

ACGGACCAAGCGAGAGGCCAGCCAGCAGCCGACGGCAAGCGCGAACACCAG

GCGGCCCCAGCACAGAACAGCCCTGACACAAGGCCACCACCAGCCACCCCAA

TCTGCATCCTCCTCGTGGGACCCCCGAGGACCAACCCCCAAGGCTGCCCCCG

ATCCAAACCACCAACCGCATCCCCACCACCCCCGGGAAAGAAACCCCCAGCA

ATTGGAAGGCCCCTCCCCCTCTTCCTCAACACAAGAACTCCACAACCGAACC

GCACAAGCGACCGAGGTGACCCAACCGCAGGCATCCGACTCCCTAGACAGAT

CCTCTCTCCCCGGCAAACTAAACAAAACTTAGGGCCAAGGAACATACACACC

CAACAGAACCCAGACCCCGGCCCACGGCGCCGCGCCCCCAACCCCCGACAAC

CAGAGGGAGCCCCCAACCAATCCCGCCGGCTCCCCCGGTGCCCACAGGCAGG

GACACCAACCCCCGAACAGACCCAGCACCCAACCATCGACAATCCAAGACGG

GGGGGCCCCCCCAAAAAAAGGCCCCCAGGGGCCGACAGCCAGCACCGCGAG

GAAGCCCACCCACCCCACACACGACCACGGCAACCAAACCAGAACCCAGAC

CACCCTGGGCCACCAGCTCCCAGACTCGGCCATCACCCCGCAGAAAGGAAAG

GCCACAACCCGCGCACCCCAGCCCCGATCCGGCGGGGAGCCACCCAACCCGA

ACCAGCACCCAAGAGCGATCCCCGAAGGACCCCCGAACCGCAAAGGACATC AGTATCCCACAGCCTCTCCAAGTCCCCCGGTCTCCTCCTCTTCTCGAAGGGAC

CAAAAGATCAATCCACCACACCCGACGACACTCAACTCCCCACCCCTAAAGG

AGACACCGGGAATCCCAGAATCAAGACTCATCCAATGTCCATCATGGGTCTC

AAGGTGAACGTCTCTGCCATATTCATGGCAGTACTGTTAACTCTCCAAACACC

C AC CGGT C A A ATCC ATT GGGGC A AT C TC TC T A AG AT AGGGGT GGT AGGA AT A

GGAAGTGCAAGCTACAAAGTTATGACTCGTTCCAGCCATCAATCATTAGTCAT

AAAATTAATGCCCAATATAACTCTCCTCAATAACTGCACGAGGGTAGAGATT

GCAGAATACAGGAGACTACTGAGAACAGTTTTGGAACCAATTAGAGATGCAC

TTAATGCAATGACCCAGAATATAAGACCGGTTCAGAGTGTAGCTTCAAGTAG

GAGACACAAGAGATTTGCGGGAGTAGTCCTGGCAGGTGCGGCCCTAGGCGTT

GCCACAGCTGCTCAGATAACAGCCGGCATTGCACTTCACCAGTCCATGCTGA

ACTCTCAAGCCATCGACAATCTGAGAGCGAGCCTGGAAACTACTAATCAGGC

AATTGAGACAATCAGACAAGCAGGGCAGGAGATGATATTGGCTGTTCAGGGT

GTCCAAGACTACATCAATAATGAGCTGATACCGTCTATGAACCAACTATCTTG

TGATTTAATCGGCCAGAAGCTCGGGCTCAAATTGCTCAGATACTATACAGAA

ATCCTGTCATTATTTGGCCCCAGTTTACGGGACCCCATATCTGCGGAGATATC

TATCCAGGCTTTGAGCTATGCGCTTGGAGGAGACATCAATAAGGTGTTAGAA

AAGCTCGGATACAGTGGAGGTGATTTACTGGGCATCTTAGAGAGCGGAGGAA

TAAAGGCCCGGATAACTCACGTCGACACAGAGTCCTACTTCATTGTCCTCAGT

ATAGCCTATCCGACGCTGTCCGAGATTAAGGGGGTGATTGTCCACCGGCTAG

AGGGGGTCTCGT AC AAC AT AGGCTCTC AAGAGT GGT AT ACC ACTGT GCCC AA

GTATGTTGCAACCCAAGGGTACCTTATCTCGAATTTTGATGAGTCATCGTGTA

CTTTCATGCCAGAGGGGACTGTGTGCAGCCAAAATGCCTTGTACCCGATGAG

TCCTCTGCTCCAAGAATGCCTCCGGGGGTACACCAAGTCCTGTGCTCGTACAC

TCGTATCCGGGTCTTTTGGGAACCGGTTCATTTTATCACAAGGGAACCTAATA

GCCAATTGTGCATCAATCCTTTGCAAGTGTTACACAACAGGAACGATCATTAA

TCAAGACCCTGACAAGATCCTAACATACATTGCTGCCGATCACTGCCCGGTA

GTCGAGGT GAACGGCGT GACC ATCC AAGTCGGGAGC AGGAGGT ATCC AGAC

GCTGTGTACTTGCACAGAATTGACCTCGGTCCTCCCATATCATTGGAGAGGTT

GGACGT AGGGAC AAATCTGGGGAAT GC AATT GCT A AGTT GGAGGAT GCC AAG

GAATTGTT GGAGT C ATCGGACC AGAT ATT GAGGAGT ATGAAAGGTTT ATCGA

GCACTAGCATAGTCTACATCCTGATTGCAGTGTGTCTTGGAGGGTTGATAGGG

ATCCCCGCTTT AAT AT GTT GCTGC AGGGGGCGTTGT AAC AAAAAGGGAGAAC

AAGTTGGTATGTCAAGACCAGGCCTAAAGCCTGATCTTACGGGAACATCAAA ATCCTATGTAAGGTCGCTCTGATCCTCTACAACTCTTGAAACACAAATGTCCC

ACAAGTCTCCTCTTCGTCATCAAGCAACCACCGCACCCAGCATCAAGCCCACC

TGAAATTATCTCCGGCTTCCCTCTGGCCGAACAATATCGGTAGTTAATTAAAA

CTTAGGGTGCAAGATCATCGATAATGTCACCACAACGAGACCGGATAAATGC

CTTCTACAAAGATAACCCCCATCCCAAGGGAAGTAGGATAGTCATTAACAGA

GAACATCTTATGATTGATAGACCTTATGTTTTGCTGGCTGTTCTGTTTGTCATG

TTTCTGAGCTTGATCGGGTTGCTAGCCATTGCAGGAATTCGACTTCATCGGGC

AGCCATCTACACCGCAGAGATCCATAAAAGCCTCAGCACCAATCTAGATGTA

ACTAACTCAATCGAGCATCAGGTCAAGGACGTGCTGACACCACTCTTCAAAA

TCATCGGTGATGAAGTGGGCCTGAGGACACCTCAGAGATTCACTGACCTAGT

GAAATTAATCTCTGACAAGATTAAATTCCTTAATCCGGATAGGGAGTACGAC

TT C AGAGATCTC ACTT GGT GT AT C A ACCCGCC AGAGAGAAT C AAATTGGATT

AT GATC AAT ACTGT GC AGAT GT GGCTGCTGAAGAGCTC AT GAATGC ATT GGT

GAACTCAACTCTACTGGAGACCAGAACAACCAATCAGTTCCTAGCTGTCTCA

AAGGGAAACTGCTCAGGGCCCACTACAATCAGAGGTCAATTCTCAAACATGT

CGCTGTCCCTGTTAGACTTGTATTTAGGTCGAGGTTACAATGTGTCATCTATA

GTCACTATGACATCCCAGGGAATGTATGGGGGAACTTACCTAGTGGAAAAGC

CTAATCTGAGCAGCAAAAGGTCAGAGTTGTCACAACTGAGCATGTACCGAGT

GTTTGAAGTAGGTGTTATCAGAAATCCGGGTTTGGGGGCTCCGGTGTTCCATA

TGACAAACTATCTTGAGCAACCAGTCAGTAATGATCTCAGCAACTGTATGGT

GGCTTTGGGGGAGCTCAAACTCGCAGCCCTTTGTCACGGGGAAGATTCTATC

AC A ATTCCC T AT C AGGGAT C AGGGA A AGGT GT C AGC TTCC AGC T C GT C A AGC

TAGGTGTCTGGAAATCCCCAACCGACATGCAATCCTGGGTCCCCTTATCAACG

GATGATCCAGTGATAGACAGGCTTTACCTCTCATCTCACAGAGGTGTTATCGC

TGACAACCAAGCAAAATGGGCTGTCCCGACAACACGAACAGATGACAAGTTG

CGAATGGAGACATGCTTCCAACAGGCGTGTAAGGGTAAAATCCAAGCACTCT

GCGAGAATCCCGAGTGGGCACCATTGAAGGATAACAGGATTCCTTCATACGG

GGTCTTGTCTGTTGATCTGAGTCTGACAGTTGAGCTTAAAATCAAAATTGCTT

CGGGATTCGGGCCATTGATCACACACGGTTCAGGGATGGACCTATACAAATC

CAACCACAACAATGTGTATTGGCTGACTATCCCGCCAATGAAGAACCTAGCC

TTAGGTGTAATCAACACATTGGAGTGGATACCGAGATTCAAGGTTAGTCCCT

ACCTCTTCACTGTCCCAATTAAGGAAGCAGGCGAAGACTGCCATGCCCCAAC

ATACCTACCTGCGGAGGTGGATGGTGATGTCAAACTCAGTTCCAATCTGGTG

ATTCTACCTGGTCAAGATCTCCAATATGTTTTGGCAACCTACGATACTTCCAG GGTTGAACATGCTGTGGTTTATTACGTTTACAGCCCAAGCCGCTCATTTTCTT

ACTTTTATCCTTTTAGGTTGCCTATAAAGGGGGTCCCCATCGAATTACAAGTG

GAATGCTTCACATGGGACCAAAAACTCTGGTGCCGTCACTTCTGTGTGCTTGC

GGACTC AGA AT C T GGT GGAC AT AT C ACTC ACTCTGGGAT GGT GGGC AT GGG A

GT C AGCTGC AC AGT C ACCCGGGAAGAT GGAACC AATCGC AGAT AGGGCTGCT

AGTGAACCAATCACATGATGTCACCCAGACATCAGGCATACCCACTAGTGTG

AAAT AG AC AT C AGAATT AAGAAAAACGT AGGGTCC AAGT GGTTCCCCGTT AT

GGACTCGCTATCTGTCAACCAGATCTTATACCCTGAAGTTCACCTAGATAGCC

CGATAGTTACCAATAAGATAGTAGCCATCCTGGAGTATGCTCGAGTCCCTCAC

GCTTACAGCCTGGAGGACCCTACACTGTGTCAGAACATCAAGCACCGCCTAA

AAAACGGATTTTCCAACCAAATGATTATAAACAATGTGGAAGTTGGGAATGT

CATCAAGTCCAAGCTTAGGAGTTATCCGGCCCACTCTCATATTCCATATCCAA

ATTGT A ATC AGGATTT ATTT A AC AT AGA AG AC A A AG AGT C A AC GAGGA AGAT

CCGTGAACTCCTCAAAAAGGGGAATTCGCTGTACTCCAAAGTCAGTGATAAG

GTTTTCCAATGCTTAAGGGACACTAACTCACGGCTTGGCCTAGGCTCCGAATT

GAGGGAGGACATCAAGGAGAAAGTTATTAACTTGGGAGTTTACATGCACAGC

TCCCAGTGGTTTGAGCCCTTTCTGTTTTGGTTTACAGTCAAGACTGAGATGAG

GTCAGTGATTAAATCACAAACCCATACTTGCCATAGGAGGAGACACACACCT

GTATTCTTCACTGGTAGTTCAGTTGAGTTGCTAATCTCTCGTGACCTTGTTGCT

ATAATCAGTAAAGAGTCTCAACATGTATATTACCTGACATTTGAACTGGTTTT

GATGTATTGTGATGTCATAGAGGGGAGGTTAATGACAGAGACCGCTATGACT

ATTGAT GCT AGGT AT AC AGAGC TTCT AGGA AGAGT C AGAT AC AT GT GGA A AC

TGATAGATGGTTTCTTCCCTGCACTCGGGAATCCAACTTATCAAATTGTAGCC

ATGCTGGAGCCTCTTTCACTTGCTTACCTGCAGCTGAGGGATATAACAGTAGA

ACTCAGAGGTGCTTTCCTTAACCACTGCTTTACTGAAATACATGATGTTCTTG

ACCAAAACGGGTTTTCTGATGAAGGTACTTATCATGAGTTAACTGAAGCTCTA

GATTACATTTTCATAACTGATGACATACATCTGACAGGGGAGATTTTCTCATT

TTTCAGAAGTTTCGGCCACCCCAGACTTGAAGCAGTAACGGCTGCTGAAAAT

GT T AGGA A AT AC AT G A AT C AGC C T A A AGT C ATT GT GT AT GAG AC TC T GAT G A

AAGGT CAT GCC AT ATTTT GT GGAAT CAT AAT C AACGGCT ATCGTGAC AGGC A

CGGAGGCAGTTGGCCACCGCTGACCCTCCCCCTGCATGCTGCAGACACAATC

CGGAATGCTCAAGCTTCAGGTGAAGGGTTAACACATGAGCAGTGCGTTGATA

ACTGGAAATCTTTTGCTGGAGTGAAATTTGGCTGCTTTATGCCTCTTAGCCTG

GATAGTGATCTGACAATGTACCTAAAGGACAAGGCACTTGCTGCTCTCCAAA GGGAATGGGATTCAGTTTACCCGAAAGAGTTCCTGCGTTACGACCCTCCCAA

GGGAACCGGGTCACGGAGGCTTGTAGATGTTTTCCTTAATGATTCGAGCTTTG

ACCCATATGATGTGATAATGTATGTTGTAAGTGGAGCTTACCTCCATGACCCT

GAGTTCAACCTGTCTTACAGCCTGAAAGAAAAGGAGATCAAGGAAACAGGTA

GACTTTTTGCTAAAATGACTTACAAAATGAGGGCATGCCAAGTGATTGCTGA

AAATCT AATCTC AAACGGGATTGGC AAAT ATTTT AAGGAC AAT GGGAT GGCC

AAGGATGAGCACGATTTGACTAAGGCACTCCACACTCTAGCTGTCTCAGGAG

TCCCC AAAGATCTC AAAGAAAGTC AC AGGGGGGGGCC AGTCTT AAA AACCT A

CTCCCGAAGCCCAGTCCACACAAGTACCAGGAACGTGAGAGCAGCAAAAGG

GTTTATAGGGTTCCCTCAAGTAATTCGGCAGGACCAAGACACTGATCATCCG

GAGAATATGGAAGCTTACGAGACAGTCAGTGCATTTATCACGACTGATCTCA

AGAAGTACTGCCTTAATTGGAGATATGAGACCATCAGCTTGTTTGCACAGAG

GCTAAATGAGATTTACGGATTGCCCTCATTTTTCCAGTGGCTGCATAAGAGGC

TTGAGACCTCTGTCCTGTATGTAAGTGACCCTCATTGCCCCCCCGACCTTGAC

GCCCATATCCCGTTATATAAAGTCCCCAATGATCAAATCTTCATTAAGTACCC

T AT GGGAGGT AT AGA AGGGT ATT GT C AGA AGCTGT GGAC CAT C AGC ACC ATT

CCCTATCTATACCTGGCTGCTTATGAGAGCGGAGTAAGGATTGCTTCGTTAGT

GCAAGGGGACAATCAGACCATAGCCGTAACAAAAAGGGTACCCAGCACATG

GCCCTACAACCTTAAGAAACGGGAAGCTGCTAGAGTAACTAGAGATTACTTT

GTAATTCTTAGGCAAAGGCTACATGATATTGGCCATCACCTCAAGGCAAATG

AGAC AATT GTTT CAT C AC ATTTTTTTGTCT ATTC A AAAGGAAT AT ATT ATGAT G

GGCTACTTGTGTCCCAATCACTCAAGAGCATCGCAAGATGTGTATTCTGGTCA

GAG AC TAT AGTTGAT GA A AC A AGGGC AGC AT GC AGT AAT ATT GCT AC A AC A A

TGGCTAAAAGCATCGAGAGAGGTTATGACCGTTACCTTGCATATTCCCTGAAC

GTCCTAAAAGTGATACAGCAAATTCTGATCTCTCTTGGCTTCACAATCAATTC

AACCATGACCCGGGATGTAGTCATACCCCTCCTCACAAACAACGACCTCTTA

ATAAGGATGGCACTGTTGCCCGCTCCTATTGGGGGGATGAATTATCTGAATAT

GAGCAGGCTGTTTGTCAGAAACATCGGTGATCCAGTAACATCATCAATTGCT

GATCTCAAGAGAATGATTCTCGCCTCACTAATGCCTGAAGAGACCCTCCATCA

GGTAATGACACAACAACCGGGGGACTCTTCATTCCTAGACTGGGCTAGCGAC

CCTTACTCAGCAAATCTTGTATGTGTCCAGAGCATCACTAGACTCCTCAAGAA

CATAACTGCAAGGTTTGTCCTGATCCATAGTCCAAACCCAATGTTAAAAGGAT

T ATTCC ATGAT GAC AGT AAAGAAGAGGACGAGGGACTGGCGGC ATTCCTC AT

GGACAGGCATATTATAGTACCTAGGGCAGCTCATGAAATCCTGGATCATAGT GT C AC AGGGGC AAGAGAGTCT ATT GC AGGC AT GCTGGAT ACC AC AAA AGGCT

TGATTCGAGCCAGCATGAGGAAGGGGGGTTTAACCTCTCGAGTGATAACCAG

ATTGTCC AATT ATGACT AT GAAC A ATT C AGAGC AGGGAT GGT GCT ATT GAC A

GGAAGA AAGAGAAAT GTCCTC ATTGAC AAAGAGT CAT GTT C AGTGC AGCTGG

CGAGAGCTCTAAGAAGCCATATGTGGGCGAGGCTAGCTCGAGGACGGCCTAT

TTACGGCCTTGAGGTCCCTGATGTACTAGAATCTATGCGAGGCCACCTTATTC

GGCGTCATGAGACATGTGTCATCTGCGAGTGTGGATCAGTCAACTACGGATG

_{GTTTTTTGTCCCCTCGGGTTGCCAACTGGATGATATTGACAAGGAAACATCAT}

CCTTGAGAGTCCCATATATTGGTTCTACCACTGATGAGAGAACAGACATGAA

GCTTGCCTTCGTAAGAGCCCCAAGTCGATCCTTGCGATCTGCTGTTAGAATAG

C A AC AGT GT AC T CAT GGGC TT AC GGT GAT GAT GAT AGC TC TT GGA AC GA AGC

CTGGTTGTTGGCTAGGCAAAGGGCCAATGTGAGCCTGGAGGAGCTAAGGGTG

ATCACTCCCATCTCAACTTCGACTAATTTAGCGCATAGGTTGAGGGATCGTAG

CACTCAAGTGAAATACTCAGGTACATCCCTTGTCCGAGTGGCGAGGTATACC

ACAATCTCCAACGACAATCTCTCATTTGTCATATCAGATAAGAAGGTTGATAC

TAACTTTATATACCAACAAGGAATGCTTCTAGGGTTGGGTGTTTTAGAAACAT

TGTTTCGACTCGAGAAAGATACCGGATCATCTAACACGGTATTACATCTTCAC

GTCGAAACAGATTGTTGCGTGATCCCGATGATAGATCATCCCAGGATACCCA

GCTCCCGCAAGCTAGAGCTGAGGGCAGAGCTATGTACCAACCCATTGATATA

TGAT AAT GC ACCTTT AATT GAC AG AG AT GC AAC AAGGCT AT AC ACCC AGAGC

CATAGGAGGCACCTTGTGGAATTTGTTACATGGTCCACACCCCAACTATATCA

CATTTTAGCTAAGTCCACAGCACTATCTATGATTGACCTGGTAACAAAATTTG

AGAAGGACC AT AT GAAT GAAATTTC AGCTCTC AT AGGGGAT GAC GAT AT C AA

TAGTTTCATAACTGAGTTTCTGCTCATAGAGCCAAGATTATTCACTATCTACTT

GGGCCAGTGTGCGGCCATCAATTGGGCATTTGATGTACATTATCATAGACCAT

CAGGGAAATATCAGATGGGTGAGCTGTTGTCATCGTTCCTTTCTAGAATGAGC

AAAGGAGTGTTTAAGGTGCTTGTCAATGCTCTAAGCCACCCAAAGATCTACA

AGAAATTCTGGCATTGTGGTATTATAGAGCCTATCCATGGTCCTTCACTTGAT

GCTCAAAACTTGCACACAACTGTGTGCAACATGGTTTACACATGCTATATGAC

CTACCTCGACCTGTTGTTGAATGAAGAGTTAGAAGAGTTCACATTTCTCTTGT

GTGAAAGCGACGAGGATGTAGTACCGGACAGATTCGACAACATCCAGGCAA

AACACTTATGTGTTCTGGCAGATTTGTACTGTCAACCAGGGACCTGCCCACCA

ATTCGAGGTCTAAGACCGGTAGAGAAATGTGCAGTTCTAACCGACCATATCA

AGGCAGAGGCTATGTTATCTCCAGCAGGATCTTCGTGGAACATAAATCCAAT TATTGTAGACCATTACTCATGCTCCCTGACTTATCTCCGGCGAGGATCGATCA

AACAGATAAGATTGAGAGTTGATCCAGGATTCATTTTCGACGCCCTCGCTGA

GGTAAATGTCAGTCAGCCAAAGATCGGCAGCAACAACATCTCAAATATGAGC

ATCAAGGCTTTCAGACCCCCACACGATGATGTTGCAAAATTGCTCAAAGATA

TCAACACAAGCAAGCACAATCTTCCCATTTCAGGGGGCAATCTCGCCAATTAT

GAAATCCATGCTTTCCGCAGAATCGGGTTGAACTCATCTGCTTGCTACAAAGC

TGTTGAGATATCAACATTAATTAGGAGATGCCTTGAGCCAGGGGAGGACGGC

TTGTTCTTGGGTGAGGGATCGGGTTCTATGTTGATCACTTATAAGGAGATACT

TAAACTAAACAAGTGCTTCTATAATAGTGGGGTTTCCGCCAATTCTAGATCTG

GTCAAAGGGAATTAGCACCCTATCCCTCCGAAGTTGGCCTTGTCGAACACAG

AATGGGAGTAGGTAATATTGTCAAAGTGCTCTTTAACGGGAGGCCCGAAGTC

ACGTGGGTAGGCAGTGTAGATTGCTTCAATTTCATAGTTAGTAATATCCCTAC

CTCTAGTGTGGGGTTTATCCATTCAGATATAGAGACCTTGCCTGACAAAGATA

CTATAGAGAAGCTAGAGGAATTGGCAGCCATCTTATCGATGGCTCTGCTCCTG

GGCAAAATAGGATCAATACTGGTGATTAAGCTTATGCCTTTCAGCGGGGATTT

T GTT C AGGGATTT AT A AGTT AT GT AGGGT C TC ATT AT AGAGA AGT GA ACC TT G

TATACCCTAGATACAGCAACTTCATATCTACTGAATCTTATTTGGTTATGACA

GATCTC AAGGCT AACCGGCT AAT GAATCCTGAAAAGATT AAGC AGC AGAT AA

TTGAATCATCTGTGAGGACTTCACCTGGACTTATAGGTCACATCCTATCCATT

AAGCAACTAAGCTGCATACAAGCAATTGTGGGAGACGCAGTTAGTAGAGGTG

ATATCAATCCTACTCTGAAAAAACTTACACCTATAGAGCAGGTGCTGATCAAT

TGCGGGTTGGCAATTAACGGACCTAAGCTGTGCAAAGAATTGATCCACCATG

ATGTTGCCTCAGGGCAAGATGGATTGCTTAATTCTATACTCATCCTCTACAGG

GAGTTGGCAAGATTCAAAGACAACCAAAGAAGTCAACAAGGGATGTTCCAC

GCCTACCCCGTATTGGTAAGTAGCAGGCAACGAGAACTTATATCTAGGATCA

CCCGCAAATTTTGGGGGCACATTCTTCTTTACTCCGGGAACAAAAAGTTGATA

AATAAGTTTATCCAGAATCTCAAGTCCGGCTATCTGATACTAGACTTACACCA

GAATATCTTCGTTAAGAATCTATCCAAGTCAGAGAAACAGATTATTATGACG

GGGGGTTTGAAACGTGAGTGGGTTTTTAAGGTAACAGTCAAGGAGACCAAAG

AATGGTATAAGTTAGTCGGATACAGTGCCCTGATTAAGGACTAATTGGTTGA

ACTCCGGAACCCTAATCCTGCCCTAGGTGGTTAGGCATTATTTGCAATATATT

AAAGAAAACTTTGAAAATACGAAGTTTCTATTCCCAGCTTTGTCTGGTggccggc atAgtcccagcctcctcgctggcgctggctgggcaacattccgaggggaccgtccccAcggtaatggcgaatgggacgcgg ccgatccggctgctaacaaagcccgaaaggaagctgagttggctgctgGcGcTGgctgGgcaataactagcataacccctt ggggcctctaaacgggtcttgaggggttttttgctgaaaggaggaactatatccggatgcGGCCGCGCGCTTGGC

GTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTC

CACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATG

AGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGG

GAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGG

CGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTC

GGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGG

TT ATCC AC AGA AT C AGGGGAT A AC GC AGG A A AGA AC AT GT GAGC A A A AGGC

CAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATA

GGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTG

GCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCC

CTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTT

CTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAG

TTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTC

AGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTA

AGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAG

CGAGGT AT GT AGGCGGT GCT AC AGAGTTCTTGAAGT GGT GGCCT AACT ACGG

CTACACTAGAAGGACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCT

TCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAG

CGGT GGTTTTTTT GTTTGC AAGC AGC AGATT ACGCGC AGAAAA AAAGGATCT

CAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAA

ACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAG

ATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTA

AACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGA

TCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTA

CGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGA

CCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGG

GCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAA

TTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAAC

GTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGC

TTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGT

TGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAG

TTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGT CATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATA

CGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAA

AACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGT

TCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACC

AGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGA

ATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTA

TTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTA

TTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCC

ACCTG.

In still another embodiment, the nucleic acid comprises the sequence of SEQ ID NO: 5, shown below:

GGACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGC

AGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTT

CCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGG

GGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAA

CTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTT

TCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAA

CTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATT

TTGCCGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAA

CGCGAATTTTAACAAAATATTAACGTTTACAATTTCGCGCCATTCGCCATTCA

GGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACG

CCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCA

GGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAGTGCGCGCCGTTAAT

ACGACTCACTATAGGGAGACCCAAGCTGGCTAGCTTTGTTTGGTCTGATGAGT

CCCGTGAGGACGAAACCCGGCGTACCGGGTCACCAAACAAAGTTGGGTAAG

GATAGTTCAATCAATGATCATCTTCTAGTGCACTTAGGATTCAAGATCCTATT

AT C AGGGAC AAGAGC AGGATT AGGGAT ATCCGAGAT GGCC AC ACTTTT A AGG

AGCTTAGCATTGTTCAAAAGAAACAAGGACAAACCACCCATTACATCAGGAT

CCGGTGGAGCCATCAGAGGAATCAAACACATTATTATAGTACCAATCCCTGG

AGATTCCTCAATTACCACTCGATCCAGACTTCTGGACCGGTTGGTGAGGTTAA

TTGGAAACCCGGATGTGAGCGGGCCCAAACTAACAGGGGCACTAATAGGTAT

ATTATCCTTATTTGTGGAGTCTCCAGGTCAATTGATTCAGAGGATCACCGATG

ACCCTGACGTTAGCATAAGGCTGTTAGAGGTTGTCCAGAGTGACCAGTCACA

ATCTGGCCTTACCTTCGCATCAAGAGGTACCAACATGGAGGATGAGGCGGAC CAATACTTTTCACATGATGATCCAATTAGTAGTGATCAATCCAGGTTCGGATG

GTTCGGGAAC AAGGAAATCTC AGAT ATTGAAGT GC AAGACCCTGAGGGATT C

AACATGATTCTGGGTACCATCCTAGCCCAAATTTGGGTCTTGCTCGCAAAGGC

GGTTACGGCCCCAGACACGGCAGCTGATTCGGAGCTAAGAAGGTGGATAAAG

TACACCCAACAAAGAAGGGTAGTTGGTGAATTTAGATTGGAGAGAAAATGGT

TGGATGTGGTGAGGAACAGGATTGCCGAGGACCTCTCCTTACGCCGATTCAT

GGTCGCTCTAATCCTGGATATCAAGAGAACACCCGGAAACAAACCCAGGATT

GCTGAAAT GAT ATGT GAC ATTGAT AC AT AT ATCGT AGAGGC AGGATT AGCC A

GTTTTATCCTGACTATTAAGTTTGGGATAGAAACTATGTATCCTGCTCTTGGA

CTGCATGAATTTGCTGGTGAGTTATCCACACTTGAGTCCTTGATGAACCTTTA

CCAGCAAATGGGGGAAACTGCACCCTACATGGTAATCCTGGAGAACTCAATT

CAGAACAAGTTCAGTGCAGGATCATACCCTCTGCTCTGGAGCTATGCCATGG

GAGT AGGAGT GGAACTTGAAAACTCC AT GGGAGGTTT GAACTTT GGCCGATC

TTACTTTGATCCAGCATATTTTAGATTAGGGCAAGAGATGGTAAGGAGGTCA

GCTGGAAAGGT C AGTTCC AC ATT GGC ATCTGAACTCGGT AT C ACTGCCGAGG

AT GC AAGGCTT GTTTC AGAGATTGC AAT GC AT ACT ACTGAGGAC A AGATC AG

TAGAGCGGTTGGACCCAGACAAGCCCAAGTATCATTTCTACACGGTGATCAA

AGTGAGAATGAGCTACCGAGATTGGGGGGCAAGGAAGATAGGAGGGTCAAA

C AGAGT C GAGGAGA AGC C AGGGAGAGCT AC AGAGA A ACC GGGCC C AGC AGA

GCAAGTGATGCGAGAGCTGCCCATCTTCCAACCGGCACACCCCTAGACATTG

ACACTGCAACGGAGTCCAGCCAAGATCCGCAGGACAGTCGAAGGTCAGCTGA

CGCCCTGCTT AGGCTGC AAGCC AT GGC AGGAATCTCGGAAGAAC AAGGCTC A

GACACGGACACCCCTATAGTGTACAATGACAGAAATCTTCTAGACTAGGTGC

GAGAGGCCGAGGGCCAGAACAACATCCGCCTACCATCCATCATTGTTATAAA

AAACTTAGGAACCAGGTCCACACAGCCGCCAGCCCATCAACCATCCACTCCC

ACGATTGGAGCCAATGGCAGAAGAGCAGGCACGCCATGTCAAAAACGGACT

GGAATGCATCCGGGCTCTCAAGGCCGAGCCCATCGGCTCACTGGCCATCGAG

GA AGC TAT GGC AGC AT GGTC AGA A AT AT C AGAC A AC CC AGGAC AGGAGC GA

GCCACCTGCAGGGAAGAGAAGGCAGGCAGTTCGGGTCTCAGCAAACCATGCC

TCTCAGCAATTGGATCAACTGAAGGCGGTGCACCTCGCATCCGCGGTCAGGG

ACCTGGAGAGAGCGATGACGACGCTGAAACTTTGGGAATCCCCCCAAGAAAT

CTCCAGGCATCAAGCACTGGGTTACAGTGTTATTACGTTTATGATCACAGCGG

TGAAGCGGTTAAGGGAATCCAAGATGCTGACTCTATCATGGTTCAATCAGGC

CTTGATGGT GAT AGC ACCCTCTC AGGAGGAGAC AAT GAATCTGAAAAC AGCG ATGTGGATATTGGCGAACCTGATACCGAGGGATATGCTATCACTGACCGGGG

ATCTGCTCCCATCTCTATGGGGTTCAGGGCTTCTGATGTTGAAACTGCAGAAG

GAGGGGAGATCCACGAGCTCCTGAGACTCCAATCCAGAGGCAACAACTTTCC

GAAGCTTGGGAAAACTCTCAATGTTCCTCCGCCCCCGGACCCCGGTAGGGCC

AGCACTTCCGGGACACCCATTAAAAAGGGCACAGACGCGAGATTAGCCTCAT

TTGGAACGGAGATCGCGTCTTTATTGACAGGTGGTGCAACCCAATGTGCTCG

AAAGTCACCCTCGGAACCATCAGGGCCAGGTGCACCTGCGGGGAATGTCCCC

GAGTGTGTGAGCAATGCCGCACTGATACAGGAGTGGACACCCGAATCTGGTA

CCACAATCTCCCCGAGATCCCAGAATAATGAAGAAGGGGGAGACTATTATGA

TGATGAGCTGTTCTCTGATGTCCAAGATATTAAAACAGCCTTGGCCAAAATAC

ACGAGGATAATCAGAAGATAATCTCCAAGCTAGAATCACTGCTGTTATTGAA

GGGAGAAGTTGAGTCAATTAAGAAGCAGATCAACAGGCAAAATATCAGCAT

ATCCACCCTGGAAGGACACCTCTCAAGCATCATGATCGCCATTCCTGGACTTG

GGAAGGATCCCAACGACCCCACTGCAGATGTCGAAATCAATCCCGACTTGAA

ACCCATCATAGGCAGAGATTCAGGCCGAGCACTGGCCGAAGTTCTCAAGAAA

CCCGTTGCCAGCCGACAACTCCAAGGAATGACAAATGGACGGACCAGTTCCA

GAGGAC AGCTGCTGAAGGAATTTC AGCT AAAGCCGATCGGGAAAAAGATGA

GCTCAGCCGTCGGGTTTGTTCCTGACACCGGCCCTGCATCACGCAGTGTAATC

CGCTCCATTATAAAATCCAGCCGGCTAGAGGAGGATCGGAAGCGTTACCTGA

TGACTCTCCTTGATGATATCAAAGGAGCCAATGATCTTGCCAAGTTCCACCAG

ATGCTGATGAAGATAATAATGAAGTAGCTACAGCTCAACTTACCTGCCAACC

CCATGCCAGTCGACCCACCTAGTACAACCTAAATCCATTATAAAAAACTTAG

GAGCAAAGTGATTGCCTCCCAAGGTCCACAATGACAGAGACCTACGACTTCG

ACAAGTCGGCATGGGACATCAAAGGGTCGATCGCTCCGATACAACCCACCAC

CTACAGTGATGGCAGGCTGGTGCCCCAGGTCAGAGTCATAGATCCTGGTCTA

GGC GAC AGGA AGGAT GA AT GC THAT GT AC AT GTTTCTGC T GGGGGTT GTT GA

GGACAGCGATTCCCTAGGGCCTCCAATCGGGCGAGCATTTGGGTTCCTGCCCT

TAGGTGTTGGCAGATCCACAGCAAAGCCCGAAAAACTCCTCAAAGAGGCCAC

T GAGCTT GAC AT AGTTGTT AGACGT AC AGC AGGGCTC AATGAAAAACTGGT G

TTCTACAACAACACCCCACTAACTCTCCTCACACCTTGGAGAAAGGTCCTAAC

AACAGGGAGTGTCTTCAACGCAAACCAAGTGTGCAATGCGGTTAATCTGATA

CCGCTCGATACCCCGCAGAGGTTCCGTGTTGTTTATATGAGCATCACCCGTCT

TTCGGAT AACGGGT ATT AC ACCGTTCCT AGAAGAAT GCTGGAATT C AGATCG

GTCAATGCAGTGGCCTTCAACCTGCTGGTGACCCTTAGGATTGACAAGGCGA TAGGCCCTGGGAAGATCATCGACAATACAGAGCAACTTCCTGAGGCAACATT

T ATGGTCC AC ATCGGGAACTTC AGGAGAAAGAAGAGT GAAGTCT ACTCTGCC

GATT ATTGC AAAAT GAAAATCGAAAAGAT GGGCCTGGTTTTTGC ACTTGGT G

GGATAGGGGGCACCAGTCTTCACATTAGAAGCACAGGCAAAATGAGCAAGA

CTCTCCATGCACAACTCGGGTTCAAGAAGACCTTATGTTACCCGCTGATGGAT

ATCAATGAAGACCTTAATCGATTACTCTGGAGGAGCAGATGCAAGATAGTAA

GAATCCAGGCAGTTTTGCAGCCATCAGTTCCTCAAGAATTCCGCATTTACGAC

GACGTGATCATAAATGATGACCAAGGACTATTCAAAGTTCTGTAGACCGTAG

TGCCCAGCAATGCCCGAAAACGACCCCCCTCACAATGACAGCCAGAAGGCCC

GGACAAAAAAGCCCCCTCCGAAAGACTCCACGGACCAAGCGAGAGGCCAGC

CAGCAGCCGACGGCAAGCGCGAACACCAGGCGGCCCCAGCACAGAACAGCC

CTGACACAAGGCCACCACCAGCCACCCCAATCTGCATCCTCCTCGTGGGACC

CCCGAGGACCAACCCCCAAGGCTGCCCCCGATCCAAACCACCAACCGCATCC

CCACCACCCCCGGGAAAGAAACCCCCAGCAATTGGAAGGCCCCTCCCCCTCT

TCCTCAACACAAGAACTCCACAACCGAACCGCACAAGCGACCGAGGTGACCC

AACCGCAGGCATCCGACTCCCTAGACAGATCCTCTCTCCCCGGCAAACTAAA

CAAAACTTAGGGCCAAGGAACATACACACCCAACAGAACCCAGACCCCGGC

CCACGGCGCCGCGCCCCCAACCCCCGACAACCAGAGGGAGCCCCCAACCAAT

CCCGCCGGCTCCCCCGGTGCCCACAGGCAGGGACACCAACCCCCGAACAGAC

CCAGCACCCAACCATCGACAATCCAAGACGGGGGGGCCCCCCCAAAAAAAG

GCCCCCAGGGGCCGACAGCCAGCACCGCGAGGAAGCCCACCCACCCCACAC

ACGACCACGGCAACCAAACCAGAACCCAGACCACCCTGGGCCACCAGCTCCC

AGACTCGGCCATCACCCCGCAGAAAGGAAAGGCCACAACCCGCGCACCCCA

GCCCCGATCCGGCGGGGAGCCACCCAACCCGAACCAGCACCCAAGAGCGATC

CCCGAAGGACCCCCGAACCGCAAAGGACATCAGTATCCCACAGCCTCTCCAA

GTCCCCCGGTCTCCTCCTCTTCTCGAAGGGACCAAAAGATCAATCCACCACAC

CCGACGACACTCAACTCCCCACCCCTAAAGGAGACACCGGGAATCCCAGAAT

CAAGACTCATCCAATGTCCATCATGGGTCTCAAGGTGAACGTCTCTGCCATAT

TCATGGCAGTACTGTTAACTCTCCAAACACCCACCGGTCAAATCCATTGGGGC

A ATCTCTCT A AGAT AGGGGT GGT AGGA AT AGGA AGT GC A AGC T AC A A AGTT A

TGACTCGTTCCAGCCATCAATCATTAGTCATAAAATTAATGCCCAATATAACT

CTCCTCAATAACTGCACGAGGGTAGAGATTGCAGAATACAGGAGACTACTGA

GAACAGTTTTGGAACCAATTAGAGATGCACTTAATGCAATGACCCAGAATAT

AAGACCGGTTCAGAGTGTAGCTTCAAGTAGGAGACACAAGAGATTTGCGGGA GTAGTCCTGGCAGGTGCGGCCCTAGGCGTTGCCACAGCTGCTCAGATAACAG

CCGGCATTGCACTTCACCAGTCCATGCTGAACTCTCAAGCCATCGACAATCTG

AGAGCGAGCCTGGAAACTACTAATCAGGCAATTGAGACAATCAGACAAGCA

GGGCAGGAGATGATATTGGCTGTTCAGGGTGTCCAAGACTACATCAATAATG

AGCTGATACCGTCTATGAACCAACTATCTTGTGATTTAATCGGCCAGAAGCTC

GGGCTCAAATTGCTCAGATACTATACAGAAATCCTGTCATTATTTGGCCCCAG

TTTACGGGACCCCATATCTGCGGAGATATCTATCCAGGCTTTGAGCTATGCGC

TTGGAGGAGAC AT C AAT AAGGT GTT AGAAAAGCTCGGAT AC AGTGGAGGTGA

TTTACTGGGCATCTTAGAGAGCGGAGGAATAAAGGCCCGGATAACTCACGTC

GACACAGAGTCCTACTTCATTGTCCTCAGTATAGCCTATCCGACGCTGTCCGA

GATTAAGGGGGTGATTGTCCACCGGCTAGAGGGGGTCTCGTACAACATAGGC

TCTCAAGAGTGGTATACCACTGTGCCCAAGTATGTTGCAACCCAAGGGTACCT

TATCTCGAATTTTGATGAGTCATCGTGTACTTTCATGCCAGAGGGGACTGTGT

GCAGCCAAAATGCCTTGTACCCGATGAGTCCTCTGCTCCAAGAATGCCTCCGG

GGGTACACCAAGTCCTGTGCTCGTACACTCGTATCCGGGTCTTTTGGGAACCG

GTTCATTTTATCACAAGGGAACCTAATAGCCAATTGTGCATCAATCCTTTGCA

AGT GTT AC AC AAC AGGAACGAT C ATT AAT C AAGACCCTGAC AAGATCCT AAC

ATACATTGCTGCCGATCACTGCCCGGTAGTCGAGGTGAACGGCGTGACCATC

CAAGTCGGGAGCAGGAGGTATCCAGACGCTGTGTACTTGCACAGAATTGACC

TCGGTCCTCCCATATCATTGGAGAGGTTGGACGTAGGGACAAATCTGGGGAA

TGCAATTGCTAAGTTGGAGGATGCCAAGGAATTGTTGGAGTCATCGGACCAG

ATATTGAGGAGTATGAAAGGTTTATCGAGCACTAGCATAGTCTACATCCTGAT

TGCAGTGTGTCTTGGAGGGTTGATAGGGATCCCCGCTTTAATATGTTGCTGCA

GGGGGC GTT GT A AC A A A A AGGGAGA AC A AGTT GGT AT GT C A AGACC AGGCC

TAAAGCCTGATCTTACGGGAACATCAAAATCCTATGTAAGGTCGCTCTGATCC

TCTACAACTCTTGAAACACAAATGTCCCACAAGTCTCCTCTTCGTCATCAAGC

AACCACCGCACCCAGCATCAAGCCCACCTGAAATTATCTCCGGCTTCCCTCTG

GCCGAACAATATCGGTAGTTAATTAAAACTTAGGGTGCAAGATCATCGATAA

TGTCACCACAACGAGACCGGATAAATGCCTTCTACAAAGATAACCCCCATCC

C AAGGGAAGT AGGAT AGT C ATT A AC AGAGAAC ATCTT AT GATT GAT AGACCT

TATGTTTTGCTGGCTGTTCTGTTTGTCATGTTTCTGAGCTTGATCGGGTTGCTA

GCCATTGCAGGAATTCGACTTCATCGGGCAGCCATCTACACCGCAGAGATCC

ATAAAAGCCTCAGCACCAATCTAGATGTAACTAACTCAATCGAGCATCAGGT

CAAGGACGTGCTGACACCACTCTTCAAAATCATCGGTGATGAAGTGGGCCTG AGGAC ACC T C AGAGATT C AC T GAC CT AGT GA A ATT A AT C TC T G AC A AG ATT A

AATTCCTTAATCCGGATAGGGAGTACGACTTCAGAGATCTCACTTGGTGTATC

AACCCGCCAGAGAGAATCAAATTGGATTATGATCAATACTGTGCAGATGTGG

CTGCTGAAGAGCTCATGAATGCATTGGTGAACTCAACTCTACTGGAGACCAG

AACAACCAATCAGTTCCTAGCTGTCTCAAAGGGAAACTGCTCAGGGCCCACT

ACAATCAGAGGTCAATTCTCAAACATGTCGCTGTCCCTGTTAGACTTGTATTT

AGGTCGAGGTTACAATGTGTCATCTATAGTCACTATGACATCCCAGGGAATGT

AT GGGGGAACTT ACCT AGT GGAAAAGCCT AATCTGAGC AGC AAAAGGTC AGA

GTTGTCACAACTGAGCATGTACCGAGTGTTTGAAGTAGGTGTTATCAGAAATC

CGGGTTTGGGGGCTCCGGTGTTCCATATGACAAACTATCTTGAGCAACCAGTC

AGT AATGATCTC AGC AACTGT AT GGT GGCTTT GGGGGAGCTC AAACTCGC AG

CCCTTTGTCACGGGGAAGATTCTATCACAATTCCCTATCAGGGATCAGGGAA

AGGTGTCAGCTTCCAGCTCGTCAAGCTAGGTGTCTGGAAATCCCCAACCGAC

ATGCAATCCTGGGTCCCCTTATCAACGGATGATCCAGTGATAGACAGGCTTTA

CCTCTCATCTCACAGAGGTGTTATCGCTGACAACCAAGCAAAATGGGCTGTCC

CGAC AAC ACGAAC AGAT GAC AAGTT GCGAAT GG AG AC AT GCTTCC AAC AGGC

GTGTAAGGGTAAAATCCAAGCACTCTGCGAGAATCCCGAGTGGGCACCATTG

AAGGATAACAGGATTCCTTCATACGGGGTCTTGTCTGTTGATCTGAGTCTGAC

AGTTGAGCTTAAAATCAAAATTGCTTCGGGATTCGGGCCATTGATCACACAC

GGTTCAGGGATGGACCTATACAAATCCAACCACAACAATGTGTATTGGCTGA

CTATCCCGCCAATGAAGAACCTAGCCTTAGGTGTAATCAACACATTGGAGTG

GATACCGAGATTCAAGGTTAGTCCCTACCTCTTCACTGTCCCAATTAAGGAAG

CAGGCGAAGACTGCCATGCCCCAACATACCTACCTGCGGAGGTGGATGGTGA

TGTCAAACTCAGTTCCAATCTGGTGATTCTACCTGGTCAAGATCTCCAATATG

TTTTGGCAACCTACGATACTTCCAGGGTTGAACATGCTGTGGTTTATTACGTTT

ACAGCCCAAGCCGCTCATTTTCTTACTTTTATCCTTTTAGGTTGCCTATAAAGG

GGGTCCCCATCGAATTACAAGTGGAATGCTTCACATGGGACCAAAAACTCTG

GTGCCGTCACTTCTGTGTGCTTGCGGACTCAGAATCTGGTGGACATATCACTC

ACTCTGGGATGGTGGGCATGGGAGTCAGCTGCACAGTCACCCGGGAAGATGG

AACCAATCGCAGATAGGGCTGCTAGTGAACCAATCACATGATGTCACCCAGA

CATCAGGCATACCCACCATCCATCATTGTTATAAAAAACTTAGGAACCAGGT

CCACACAGAGTGATACGCGTACGCCACCATGTTCGTGTTTCTGGTGCTGCTGC

CTCTGGTGAGCTCCCAGTGCGTGAACCTGACCACAAGGACCCAGCTGCCCCC

TGCCTATACCAATTCCTTCACACGGGGCGTGTACTATCCCGACAAGGTGTTCC GGAGCAGCGTGCTGCACTCCACACAGGATCTGTTTCTGCCTTTCTTTTCTAAC

GTGACCTGGTTCCACGCCATCCACGTGAGCGGCACCAATGGCACAAAGCGGT

TCGACAATCCAGTGCTGCCCTTTAACGATGGCGTGTACTTCGCCTCCACCGAG

AAGTCT AAC AT CAT C AGAGGCTGGATCTTT GGC ACC AC ACTGGAC AGC AAGA

CACAGTCCCTGCTGATCGTGAACAATGCCACCAACGTGGTCATCAAGGTGTG

CGAGTTCCAGTTTTGTAATGATCCATTCCTGGGCGTGTACTATCACAAGAACA

ATAAGTCTTGGATGGAGAGCGAGTTTCGCGTGTATTCCTCTGCCAACAATTGC

ACATTTGAGTACGTGTCCCAGCCCTTCCTGATGGACCTGGAGGGCAAGCAGG

GCAATTTCAAGAACCTGAGGGAGTTCGTGTTTAAGAATATCGATGGCTACTTC

AAAATCTACTCCAAGCACACCCCAATCAACCTGGTGCGCGACCTGCCACAGG

GCTTCTCTGCCCTGGAGCCACTGGTGGATCTGCCCATCGGCATCAACATCACC

CGGTTTCAGACACTGCTGGCCCTGCACAGAAGCTACCTGACACCAGGCGACA

GCTCCTCTGGATGGACCGCAGGAGCAGCAGCCTACTATGTGGGCTATCTGCA

GCCCAGGACCTTCCTGCTGAAGTACAACGAGAATGGCACCATCACAGACGCC

GTGGATTGCGCCCTGGATCCCCTGTCTGAGACCAAGTGTACACTGAAGAGCTT

T ACCGT GGAGAAGGGC ATCT ATC AGAC AAGC AATTT C AGGGT GC AGCCT ACC

GAGTCCATCGTGCGCTTTCCCAATATCACAAACCTGTGCCCTTTTGGCGAGGT

GTTCAACGC AACCCGCTTCGCCAGCGTGTACGCCTGGAATAGG AAGC GC ATC

TCCAACTGCGTGGCCGACTATTCTGTGCTGTACAACAGCGCCTCCTTCTCTAC

CTTTAAGTGCTATGGCGTGAGCCCCACAAAGCTGAATGACCTGTGCTTTACCA

ACGTGTACGCCGATTCCTTCGTGATCAGGGGCGACGAGGTGCGCCAGATCGC

ACCAGGACAGACAGGCAAGATCGCAGACTACAATTATAAGCTGCCTGACGAT

TTC ACCGGCTGCGT GATCGCCTGGAACTCT AAC AATCTGGAT AGC AAAGTGG

GCGGCAACTACAATTATCTGTACCGGCTGTTTAGAAAGTCTAATCTGAAGCCA

TTCGAGAGGGACATCTCCACAGAAATCTACCAGGCCGGCTCTACCCCCTGCA

ATGGCGTGGAGGGCTTTAACTGTTATTTCCCTCTGCAGAGCTACGGCTTCCAG

CCAACAAACGGCGTGGGCTATCAGCCCTACCGCGTGGTGGTGCTGTCTTTTGA

GCTGCTGC ACGC ACCTGC AAC AGT GTGCGGACC A AAGAAGAGC ACC AATCTG

GTGAAGAACAAGTGCGTGAACTTCAACTTCAACGGACTGACCGGAACAGGCG

TGCTGACCGAGTCCAACAAGAAGTTCCTGCCTTTTCAGCAGTTCGGCAGGGA

CATCGCAGATACCACAGACGCCGTGCGCGACCCTCAGACCCTGGAGATCCTG

GACATCACACCATGCTCCTTCGGCGGCGTGTCTGTGATCACACCAGGCACCA

ATACAAGCAACCAGGTGGCCGTGCTGTATCAGGACGTGAATTGTACCGAGGT

GCCAGTGGCAATCCACGCAGATCAGCTGACCCCTACATGGCGGGTGTACTCT ACCGGCAGCAACGTGTTCCAGACAAGAGCCGGATGCCTGATCGGAGCAGAGC

ACGTGAACAATAGCTATGAGTGCGACATCCCTATCGGCGCCGGCATCTGTGC

CTCCTACCAGACCCAGACAAACTCCCCAAGGAGAGCACGGTCTGTGGCCAGC

CAGTCCATCATCGCCTATACCATGAGCCTGGGCGCCGAGAATTCCGTGGCCTA

CTCCAACAATTCTATCGCCATCCCTACCAACTTCACAATCTCCGTGACCACAG

AGATCCTGCCAGTGAGCATGACCAAGACATCCGTGGACTGCACAATGTATAT

CTGTGGCGATTCCACCGAGTGCTCTAACCTGCTGCTGCAGTACGGCTCTTTTT

GTACCCAGCTGAATAGAGCCCTGACAGGCATCGCCGTGGAGCAGGACAAGA

ACACACAGGAGGTGTTCGCCCAGGTGAAGCAAATCTACAAGACCCCACCCAT

CAAGGACTTTGGCGGCTTCAACTTCAGCCAGATCCTGCCCGATCCTAGCAAGC

CATCCAAGCGGTCTTTTATCGAGGACCTGCTGTTCAACAAGGTGACCCTGGCC

GATGCCGGCTTCATCAAGCAGTATGGCGATTGCCTGGGCGACATCGCCGCCA

GAGACCTGATCTGTGCCCAGAAGTTTAATGGCCTGACCGTGCTGCCTCCACTG

CTGACAGATGAGATGATCGCCCAGTACACATCTGCCCTGCTGGCCGGAACCA

TCACAAGCGGATGGACCTTCGGCGCAGGAGCCGCCCTGCAGATCCCCTTTGC

CATGCAGATGGCCTATCGGTTCAACGGCATCGGCGTGACCCAGAATGTGCTG

TACGAGAACCAGAAGCTGATCGCCAATCAGTTTAACTCCGCCATCGGCAAGA

TCCAGGACTCTCTGAGCTCCACAGCCAGCGCCCTGGGCAAGCTGCAGGATGT

GGTGAATCAGAACGCCCAGGCCCTGAATACCCTGGTGAAGCAGCTGTCTAGC

AACTTCGGCGCCATCTCCTCTGTGCTGAATGACATCCTGAGCCGGCTGGACAA

GGTGGAGGCAGAGGTGCAGATCGACCGGCTGATCACAGGCAGACTGCAGTCC

CTGCAGACCTACGTGACACAGCAGCTGATCAGGGCAGCAGAGATCAGGGCCT

CTGCCAATCTGGCCGCCACCAAGATGAGCGAGTGCGTGCTGGGCCAGTCCAA

GAGAGTGGACTTTTGTGGCAAGGGCTATCACCTGATGAGCTTCCCACAGTCC

GCCCCTCACGGAGTGGTGTTTCTGCACGTGACCTACGTGCCAGCCCAGGAGA

AGAACTT C ACC AC AGC ACC AGC AATCTGCC ACGAT GGC AAGGC AC ACTTTCC

TAGGGAGGGCGTGTTCGTGAGCAACGGCACCCACTGGTTTGTGACACAGCGC

AATTTCTACGAGCCACAGATCATCACCACAGACAATACATTCGTGTCCGGCA

ACTGTGACGTGGTCATCGGCATCGTGAACAATACCGTGTATGATCCTCTGCAG

CCAGAGCTGGACTCTTTTAAGGAGGAGCTGGATAAGTACTTCAAGAATCACA

CCAGCCCCGACGTGGATCTGGGCGACATCTCTGGCATCAATGCCAGCGTGGT

GA AC AT C C AGA AGG AGATCGAC AGGC T GA AC GAGGT GGC C A AG A AT C T GA A

CGAGTCCCTGATCGATCTGCAGGAGCTGGGCAAGTATGAGCAGTACATCAAG

TGGCCCTGGTATATCTGGCTGGGCTTCATCGCCGGCCTGATCGCCATCGTGAT GGTGACCATCATGCTGTGCTGTATGACAAGCTGCTGTTCCTGCCTGAAGGGCT

GCTGTTCTTGTGGCAGCTGCTGTAAGTTTGATGAGGACGATAGCGAGCCTGTG

CTGAAGGGCGTGAAGCTGCACTACACCTGAGCTAGCGATCGCACTAGTGTGA

AAT AGAC ATC AGAATT AAGAAAA ACGT AGGGTCC AAGTGGTTCCCCGTT AT G

GACTCGCTATCTGTCAACCAGATCTTATACCCTGAAGTTCACCTAGATAGCCC

GATAGTTACCAATAAGATAGTAGCCATCCTGGAGTATGCTCGAGTCCCTCAC

GCTTACAGCCTGGAGGACCCTACACTGTGTCAGAACATCAAGCACCGCCTAA

AAAACGGATTTTCCAACCAAATGATTATAAACAATGTGGAAGTTGGGAATGT

CATCAAGTCCAAGCTTAGGAGTTATCCGGCCCACTCTCATATTCCATATCCAA

ATTGT A ATC AGGATTT ATTT A AC AT AGA AGAC A A AGAGT C A AC GAGGA AGAT

CCGTGAACTCCTCAAAAAGGGGAATTCGCTGTACTCCAAAGTCAGTGATAAG

GTTTTCCAATGCTTAAGGGACACTAACTCACGGCTTGGCCTAGGCTCCGAATT

GAGGGAGGACATCAAGGAGAAAGTTATTAACTTGGGAGTTTACATGCACAGC

TCCCAGTGGTTTGAGCCCTTTCTGTTTTGGTTTACAGTCAAGACTGAGATGAG

GTCAGTGATTAAATCACAAACCCATACTTGCCATAGGAGGAGACACACACCT

GTATTCTTCACTGGTAGTTCAGTTGAGTTGCTAATCTCTCGTGACCTTGTTGCT

ATAATCAGTAAAGAGTCTCAACATGTATATTACCTGACATTTGAACTGGTTTT

GATGTATTGTGATGTCATAGAGGGGAGGTTAATGACAGAGACCGCTATGACT

ATTGAT GCT AGGT AT AC AGAGC TTCT AGGA AGAGT C AGAT AC AT GT GGA A AC

TGATAGATGGTTTCTTCCCTGCACTCGGGAATCCAACTTATCAAATTGTAGCC

ATGCTGGAGCCTCTTTCACTTGCTTACCTGCAGCTGAGGGATATAACAGTAGA

ACTCAGAGGTGCTTTCCTTAACCACTGCTTTACTGAAATACATGATGTTCTTG

ACCAAAACGGGTTTTCTGATGAAGGTACTTATCATGAGTTAACTGAAGCTCTA

GATTACATTTTCATAACTGATGACATACATCTGACAGGGGAGATTTTCTCATT

TTTCAGAAGTTTCGGCCACCCCAGACTTGAAGCAGTAACGGCTGCTGAAAAT

GT T AGGA A AT AC AT G A AT C AGC C T A A AGT C ATT GT GT AT GAG AC TC T GAT G A

AAGGT CAT GCC AT ATTTT GT GGAAT CAT AAT C AACGGCT ATCGTGAC AGGC A

CGGAGGCAGTTGGCCACCGCTGACCCTCCCCCTGCATGCTGCAGACACAATC

CGGAATGCTCAAGCTTCAGGTGAAGGGTTAACACATGAGCAGTGCGTTGATA

ACTGGAAATCTTTTGCTGGAGTGAAATTTGGCTGCTTTATGCCTCTTAGCCTG

GATAGTGATCTGACAATGTACCTAAAGGACAAGGCACTTGCTGCTCTCCAAA

GGGAATGGGATTCAGTTTACCCGAAAGAGTTCCTGCGTTACGACCCTCCCAA

GGGAACCGGGTCACGGAGGCTTGTAGATGTTTTCCTTAATGATTCGAGCTTTG

ACCCATATGATGTGATAATGTATGTTGTAAGTGGAGCTTACCTCCATGACCCT GAGTTCAACCTGTCTTACAGCCTGAAAGAAAAGGAGATCAAGGAAACAGGTA

GACTTTTTGCTAAAATGACTTACAAAATGAGGGCATGCCAAGTGATTGCTGA

AAATCT AATCTC AAACGGGATTGGC AAAT ATTTT AAGGAC AAT GGGAT GGCC

AAGGATGAGCACGATTTGACTAAGGCACTCCACACTCTAGCTGTCTCAGGAG

TCCCC AAAGATCTC AAAGAAAGTC AC AGGGGGGGGCC AGTCTT AAA AACCT A

CTCCCGAAGCCCAGTCCACACAAGTACCAGGAACGTGAGAGCAGCAAAAGG

GTTTATAGGGTTCCCTCAAGTAATTCGGCAGGACCAAGACACTGATCATCCG

GAGAATATGGAAGCTTACGAGACAGTCAGTGCATTTATCACGACTGATCTCA

AGAAGTACTGCCTTAATTGGAGATATGAGACCATCAGCTTGTTTGCACAGAG

GCTAAATGAGATTTACGGATTGCCCTCATTTTTCCAGTGGCTGCATAAGAGGC

TTGAGACCTCTGTCCTGTATGTAAGTGACCCTCATTGCCCCCCCGACCTTGAC

GCCCATATCCCGTTATATAAAGTCCCCAATGATCAAATCTTCATTAAGTACCC

T AT GGGAGGT AT AGA AGGGT ATT GT C AGA AGCTGT GGAC CAT C AGC ACC ATT

CCCTATCTATACCTGGCTGCTTATGAGAGCGGAGTAAGGATTGCTTCGTTAGT

GCAAGGGGACAATCAGACCATAGCCGTAACAAAAAGGGTACCCAGCACATG

GCCCTACAACCTTAAGAAACGGGAAGCTGCTAGAGTAACTAGAGATTACTTT

GTAATTCTTAGGCAAAGGCTACATGATATTGGCCATCACCTCAAGGCAAATG

AGAC AATT GTTT CAT C AC ATTTTTTTGTCT ATTC A AAAGGAAT AT ATT ATGAT G

GGCTACTTGTGTCCCAATCACTCAAGAGCATCGCAAGATGTGTATTCTGGTCA

GAG AC TAT AGTTGAT GA A AC A AGGGC AGC AT GC AGT AAT ATT GCT AC A AC A A

TGGCTAAAAGCATCGAGAGAGGTTATGACCGTTACCTTGCATATTCCCTGAAC

GTCCTAAAAGTGATACAGCAAATTCTGATCTCTCTTGGCTTCACAATCAATTC

AACCATGACCCGGGATGTAGTCATACCCCTCCTCACAAACAACGACCTCTTA

ATAAGGATGGCACTGTTGCCCGCTCCTATTGGGGGGATGAATTATCTGAATAT

GAGCAGGCTGTTTGTCAGAAACATCGGTGATCCAGTAACATCATCAATTGCT

GATCTCAAGAGAATGATTCTCGCCTCACTAATGCCTGAAGAGACCCTCCATCA

GGTAATGACACAACAACCGGGGGACTCTTCATTCCTAGACTGGGCTAGCGAC

CCTTACTCAGCAAATCTTGTATGTGTCCAGAGCATCACTAGACTCCTCAAGAA

CATAACTGCAAGGTTTGTCCTGATCCATAGTCCAAACCCAATGTTAAAAGGAT

T ATTCC ATGAT GAC AGT AAAGAAGAGGACGAGGGACTGGCGGC ATTCCTC AT

GGACAGGCATATTATAGTACCTAGGGCAGCTCATGAAATCCTGGATCATAGT

GT C AC AGGGGC AAGAGAGTCT ATT GC AGGC AT GCTGGAT ACC AC AAA AGGCT

TGATTCGAGCCAGCATGAGGAAGGGGGGTTTAACCTCTCGAGTGATAACCAG

ATTGTCC AATT ATGACT AT GAAC A ATT C AGAGC AGGGAT GGT GCT ATT GAC A GGAAGA AAGAGAAAT GTCCTC ATTGAC AAAGAGT CAT GTT C AGTGC AGCTGG

CGAGAGCTCTAAGAAGCCATATGTGGGCGAGGCTAGCTCGAGGACGGCCTAT

TTACGGCCTTGAGGTCCCTGATGTACTAGAATCTATGCGAGGCCACCTTATTC

GGCGTCATGAGACATGTGTCATCTGCGAGTGTGGATCAGTCAACTACGGATG

_{GTTTTTTGTCCCCTCGGGTTGCCAACTGGATGATATTGACAAGGAAACATCAT}

CCTTGAGAGTCCCATATATTGGTTCTACCACTGATGAGAGAACAGACATGAA

GCTTGCCTTCGTAAGAGCCCCAAGTCGATCCTTGCGATCTGCTGTTAGAATAG

C A AC AGT GT AC T CAT GGGC TT ACGGT GAT GAT GAT AGC TC TT GGA AC GA AGC

CTGGTTGTTGGCTAGGCAAAGGGCCAATGTGAGCCTGGAGGAGCTAAGGGTG

ATCACTCCCATCTCAACTTCGACTAATTTAGCGCATAGGTTGAGGGATCGTAG

CACTCAAGTGAAATACTCAGGTACATCCCTTGTCCGAGTGGCGAGGTATACC

ACAATCTCCAACGACAATCTCTCATTTGTCATATCAGATAAGAAGGTTGATAC

TAACTTTATATACCAACAAGGAATGCTTCTAGGGTTGGGTGTTTTAGAAACAT

TGTTTCGACTCGAGAAAGATACCGGATCATCTAAC ACGGT ATT ACATCTTCAC

GTCGAAACAGATTGTTGCGTGATCCCGATGATAGATCATCCCAGGATACCCA

GCTCCCGCAAGCTAGAGCTGAGGGCAGAGCTATGTACCAACCCATTGATATA

TGAT AAT GC ACCTTT AATT GAC AGAGAT GC AAC AAGGCT AT AC ACCC AGAGC

CATAGGAGGCACCTTGTGGAATTTGTTACATGGTCCACACCCCAACTATATCA

CATTTTAGCTAAGTCCACAGCACTATCTATGATTGACCTGGTAACAAAATTTG

AGAAGGACC AT AT GAAT GAAATTTC AGCTCTC AT AGGGGAT GAC GAT AT C AA

TAGTTTCATAACTGAGTTTCTGCTCATAGAGCCAAGATTATTCACTATCTACTT

GGGCCAGTGTGCGGCCATCAATTGGGCATTTGATGTACATTATCATAGACCAT

CAGGGAAATATCAGATGGGTGAGCTGTTGTCATCGTTCCTTTCTAGAATGAGC

AAAGGAGTGTTTAAGGTGCTTGTCAATGCTCTAAGCCACCCAAAGATCTACA

AGAAATTCTGGCATTGTGGTATTATAGAGCCTATCCATGGTCCTTCACTTGAT

GCTCAAAACTTGCACACAACTGTGTGCAACATGGTTTACACATGCTATATGAC

CTACCTCGACCTGTTGTTGAATGAAGAGTTAGAAGAGTTCACATTTCTCTTGT

GTGAAAGCGACGAGGATGTAGTACCGGACAGATTCGACAACATCCAGGCAA

AACACTTATGTGTTCTGGCAGATTTGTACTGTCAACCAGGGACCTGCCCACCA

ATTCGAGGTCTAAGACCGGTAGAGAAATGTGCAGTTCTAACCGACCATATCA

AGGCAGAGGCTATGTTATCTCCAGCAGGATCTTCGTGGAACATAAATCCAAT

TATTGTAGACCATTACTCATGCTCCCTGACTTATCTCCGGCGAGGATCGATCA

AACAGATAAGATTGAGAGTTGATCCAGGATTCATTTTCGACGCCCTCGCTGA

GGTAAATGTCAGTCAGCCAAAGATCGGCAGCAACAACATCTCAAATATGAGC ATCAAGGCTTTCAGACCCCCACACGATGATGTTGCAAAATTGCTCAAAGATA

TCAACACAAGCAAGCACAATCTTCCCATTTCAGGGGGCAATCTCGCCAATTAT

GAAATCCATGCTTTCCGCAGAATCGGGTTGAACTCATCTGCTTGCTACAAAGC

TGTTGAGATATCAACATTAATTAGGAGATGCCTTGAGCCAGGGGAGGACGGC

TTGTTCTTGGGTGAGGGATCGGGTTCTATGTTGATCACTTATAAGGAGATACT

TAAACTAAACAAGTGCTTCTATAATAGTGGGGTTTCCGCCAATTCTAGATCTG

GTCAAAGGGAATTAGCACCCTATCCCTCCGAAGTTGGCCTTGTCGAACACAG

AATGGGAGTAGGTAATATTGTCAAAGTGCTCTTTAACGGGAGGCCCGAAGTC

ACGTGGGTAGGCAGTGTAGATTGCTTCAATTTCATAGTTAGTAATATCCCTAC

CTCTAGTGTGGGGTTTATCCATTCAGATATAGAGACCTTGCCTGACAAAGATA

CTATAGAGAAGCTAGAGGAATTGGCAGCCATCTTATCGATGGCTCTGCTCCTG

GGCAAAATAGGATCAATACTGGTGATTAAGCTTATGCCTTTCAGCGGGGATTT

T GTT C AGGGATTT AT A AGTT AT GT AGGGT C TC ATT AT AGAGA AGT GA ACC TT G

TATACCCTAGATACAGCAACTTCATATCTACTGAATCTTATTTGGTTATGACA

GATCTC AAGGCT AACCGGCT AAT GAATCCTGAAAAGATT AAGC AGC AGAT AA

TTGAATCATCTGTGAGGACTTCACCTGGACTTATAGGTCACATCCTATCCATT

AAGCAACTAAGCTGCATACAAGCAATTGTGGGAGACGCAGTTAGTAGAGGTG

ATATCAATCCTACTCTGAAAAAACTTACACCTATAGAGCAGGTGCTGATCAAT

TGCGGGTTGGCAATTAACGGACCTAAGCTGTGCAAAGAATTGATCCACCATG

ATGTTGCCTCAGGGCAAGATGGATTGCTTAATTCTATACTCATCCTCTACAGG

GAGTTGGCAAGATTCAAAGACAACCAAAGAAGTCAACAAGGGATGTTCCAC

GCCTACCCCGTATTGGTAAGTAGCAGGCAACGAGAACTTATATCTAGGATCA

CCCGCAAATTTTGGGGGCACATTCTTCTTTACTCCGGGAACAAAAAGTTGATA

AATAAGTTTATCCAGAATCTCAAGTCCGGCTATCTGATACTAGACTTACACCA

GAATATCTTCGTTAAGAATCTATCCAAGTCAGAGAAACAGATTATTATGACG

GGGGGTTTGAAACGTGAGTGGGTTTTTAAGGTAACAGTCAAGGAGACCAAAG

AATGGTATAAGTTAGTCGGATACAGTGCCCTGATTAAGGACTAATTGGTTGA

ACTCCGGAACCCTAATCCTGCCCTAGGTGGTTAGGCATTATTTGCAATATATT

AAAGAAAACTTTGAAAATACGAAGTTTCTATTCCCAGCTTTGTCTGGTggccggc atAgtcccagcctcctcgctggcgctggctgggcaacattccgaggggaccgtccccAcggtaatggcgaatgggacgcgg ccgatccggctgctaacaaagcccgaaaggaagctgagttggctgctgGcGcTGgctgGgcaataactagcataacccctt ggggcctctaaacgggtcttgaggggttttttgctgaaaggaggaactatatccggatgcGGCCGCGCGCTTGGC

GTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTC

CACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATG AGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGG

GAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGG

CGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTC

GGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGG

TT ATCC AC AGA AT C AGGGGAT A AC GC AGG A A AGA AC AT GT GAGC A A A AGGC

CAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATA

GGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTG

GCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCC

CTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTT

CTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAG

TTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTC

AGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTA

AGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAG

CGAGGT AT GT AGGCGGT GCT AC AGAGTTCTTGAAGT GGT GGCCT AACT ACGG

CTACACTAGAAGGACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCT

TCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAG

CGGT GGTTTTTTT GTTTGC AAGC AGC AGATT ACGCGC AGAAAA AAAGGATCT

CAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAA

ACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAG

ATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTA

AACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGA

TCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTA

CGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGA

CCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGG

GCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAA

TTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAAC

GTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGC

TTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGT

TGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAG

TTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTAC

TGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGT

CATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATA

CGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAA

AACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGT TCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACC

AGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGA

ATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTA

TTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTA

TTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCC

ACCTG.

In one embodiment, the nucleic acid comprises the sequence of SEQ ID NO: 6, shown below (RABV vector: Coravax Vl-China (RABVG-E31)): ACGCTTAACAACCAGATCAAAGAAAAAACAGACATTGTCAATTGCAAAGCAA AAATGTAACACCCCTACAATGGATGCCGACAAGATTGTATTCAAAGTCAATA AT C AGGT GGT C TC TT T G A AGC C T GAG AT T AT C GT GG AT C A AT AT G AGT AC A AG TACCCTGCCATCAAAGATTTGAAAAAGCCCTGTATAACCCTAGGAAAGGCTC CCGATTTAAATAAAGCATACAAGTCAGTTTTGTCAGGCATGAGCGCCGCCAA ACTTAATCCTGACGATGTATGTTCCTATTTGGCAGCGGCAATGCAGTTTTTTG AGGGGACATGTCCGGAAGACTGGACCAGCTATGGAATTGTGATTGCACGAAA AGGAGATAAGATCACCCCAGGTTCTCTGGTGGAGATAAAACGTACTGATGTA GAAGGGAATT GGGCTCTGAC AGGAGGC AT GGAACTGAC AAGAGACCCC ACT GTCCCTGAGCATGCGTCCTTAGTCGGTCTTCTCTTGAGTCTGTATAGGTTGAG CAAAATATCCGGGCAAAACACTGGTAACTATAAGACAAACATTGCAGACAGG ATAGAGCAGATTTTTGAGACAGCCCCTTTTGTTAAAATCGTGGAACACCATAC TC T A AT GAC A AC TC AC A Aa AT GT GT GCT A ATT GGAGT ACT AT AC C A A AC TTC A GATTTTTGGCCGGAACCTATGACATGTTTTTCTCCCGGATTGAGCATCTATATT CAGCAATCAGAGTGGGCACAGTTGTCACTGCTTATGAAGACTGTTCAGGACT GGTATCATTTACTGGGTTCATAAAACAAATCAATCTCACCGCTAGAGAGGCA ATACTATATTTCTTCCACAAGAACTTTGAGGAAGAGATAAGAAGAATGTTTG AGCCAGGGCAGGAGACAGCTGTTCCTCACTCTTATTTCATCCACTTCCGTTCA CTAGGCTTGAGTGGGAAATCTCCTTATTCATCAAATGCTGTTGGTCACGTGTT CAATCTCATTCACTTTGTAGGATGCTATATGGGTCAAGTCAGATCCCTAAATG CAACGGTTATTGCTGCATGTGCTCCTCATGAAATGTCTGTTCTAGGGGGCTAT CTGGGAGAGGAATTCTTCGGGAAAGGGAC ATTTGAAAGAAGATTCTTC AGAG AT GAG A A AG A AC TT C A AG A AT AC G AGGC GGC T G A AC T GAC A A AG AC T GAC G TAGCACTGGCAGATGATGGAACTGTCAACTCTGACGACGAGGACTACTTTTC AGGT GAAACC AGAAGTCCGGAGGCTGTTT AT ACTCGAAT CAT GAT GAAT GGA GGTCGACTAAAGAGATCTCACATACGGAGATATGTCTCAGTCAGTTCCAATC ATCAAGCCCGTCCAAACTCATTCGCCGAGTTTCTAAACAAGACATATTCGAGT

GACTCATAAcatgaaaaaaactaacacccctcccGTACGCCACCATGTTCGTGTTTCTGGTG

CTGCTGCCTCTGGTGAGCTCCCAGTGCGTGAACCTGACCACAAGGACCCAGC

TGCCCCCTGCCTATACCAATTCCTTCACACGGGGCGTGTACTATCCCGACAAG

GTGTTCCGGAGCAGCGTGCTGCACTCCACACAGGATCTGTTTCTGCCTTTCTT

TTCTAACGTGACCTGGTTCCACGCCATCCACGTGAGCGGCACCAATGGCACA

AAGCGGTTCGACAATCCAGTGCTGCCCTTTAACGATGGCGTGTACTTCGCCTC

CACCGAGAAGTCTAACATCATCAGAGGCTGGATCTTTGGCACCACACTGGAC

AGCAAGACACAGTCCCTGCTGATCGTGAACAATGCCACCAACGTGGTCATCA

AGGTGTGCGAGTTCCAGTTTTGTAATGATCCATTCCTGGGCGTGTACTATCAC

AAGAACAATAAGTCTTGGATGGAGAGCGAGTTTCGCGTGTATTCCTCTGCCA

ACAATTGCACATTTGAGTACGTGTCCCAGCCCTTCCTGATGGACCTGGAGGGC

AAGCAGGGCAATTTCAAGAACCTGAGGGAGTTCGTGTTTAAGAATATCGATG

GCTACTTCAAAATCTACTCCAAGCACACCCCAATCAACCTGGTGCGCGACCTG

CCACAGGGCTTCTCTGCCCTGGAGCCACTGGTGGATCTGCCCATCGGCATCAA

CATCACCCGGTTTCAGACACTGCTGGCCCTGCACAGAAGCTACCTGACACCA

GGCGACAGCTCCTCTGGATGGACCGCAGGAGCAGCAGCCTACTATGTGGGCT

ATCTGCAGCCCAGGACCTTCCTGCTGAAGTACAACGAGAATGGCACCATCAC

AGACGCCGTGGATTGCGCCCTGGATCCCCTGTCTGAGACCAAGTGTACACTG

AAGAGCTTTACCGTGGAGAAGGGCATCTATCAGACAAGCAATTTCAGGGTGC

AGCCTACCGAGTCCATCGTGCGCTTTCCCAATATCACAAACCTGTGCCCTTTT

GGCGAGGTGTTCAACGCAACCCGCTTCGCCAGCGTGTACGCCTGGAATAGGA

AGCGCATCTCCAACTGCGTGGCCGACTATTCTGTGCTGTACAACAGCGCCTCC

TTCTCTACCTTTAAGTGCTATGGCGTGAGCCCCACAAAGCTGAATGACCTGTG

CTTTACCAACGTGTACGCCGATTCCTTCGTGATCAGGGGCGACGAGGTGCGCC

AGATCGCACCAGGACAGACAGGCAAGATCGCAGACTACAATTATAAGCTGCC

TGACGATTTCACCGGCTGCGTGATCGCCTGGAACTCTAACAATCTGGATAGCA

AAGTGGGCGGCAACTACAATTATCTGTACCGGCTGTTTAGAAAGTCTAATCTG

AAGCCATTCGAGAGGGACATCTCCACAGAAATCTACCAGGCCGGCTCTACCC

CCTGCAATGGCGTGGAgGGCTTTAACTGTTATTTCCCTCTGCAGAgCTACgGCT

TCCAGCCAACAAACGGCGTGGGCTATCAGCCCTACCGCGTGGTGGTGCTGTC

TTTTGAGCTGCTGCACGCACcTGCAACAGTGTGCGGACCAAAGAAGAGCACC

A ATCTGGT GA AGA AC A AGT GCGT GA AC TT C A AC TT C A AC GGACTGACC GGA A

CAGGCGTGCTGACCGAGTCCAACAAGAAGTTCCTGCCTTTTCAGCAGTTCGGC AGGGACATCGCAGATACCACAGACGCCGTGCGCGACCCTCAGACCCTGGAGA

TCCTGGACATCACACCATGCTCCTTCGGCGGCGTGTCTGTGATCACACCAGGC

ACCAATACAAGCAACCAGGTGGCCGTGCTGTATCAGGACGTGAATTGTACCG

AGGTGCCAGTGGCAATCCACGCAGATCAGCTGACCCCTACATGGCGGGTGTA

CTCTACCGGCAGCAACGTGTTCCAGACAAGAGCCGGATGCCTGATCGGAGCA

GAGCACGTGAACAATAGCTATGAGTGCGACATCCCTATCGGCGCCGGCATCT

GTGCCTCCTACCAGACCCAGACAAACTCCCCAAGGTCTGTGGGAGATGAGGC

CGAAGACTTTGTGGAAGTCCACCTGCCTGATGTGCATAACCAGGTGTCTGGC

GTCGACCTGGGACTGCCAAATTGGGGCAAGTACGTGCTGCTGAGTGCTGGAG

CACTGACTGCCCTGATGCTGATCATTTTCCTGATGACCTGCTGTCGGCGCGTG

AACAGAAGTGAGCCCACTCAGCACAATCTGCGAGGAACCGGGAGAGAAGTG

T C AGTC AC ACCTC AGAGCGGGAAAATC ATT AGT AGTT GGGAATC AC AT AAAA

GCGGGGGCGAGACCAGGCTGTGAGCTAGCCATGAAAAAAACTAACACCCCTC

CTTTCGAACCATCCCAAACATGAGCAAGATCTTTGTCAATCCTAGTGCTATTA

GAGCCGGTCTGGCCGATCTTGAGATGGCTGAAGAAACTGTTGATCTGATCAA

T AGAAAT ATCGAAGAC AAT C AGGCTC ATCTCC AAGGGGAACCC AT AGAGGT G

GACAATCTCCCTGAGGATATGGGGCGACTTCACCTGGATGATGGAAAATCGC

CC AACC ATGGT GAG AT AGCC AAGGTGGGAGAAGGC AAGT ATCGAGAGGACT

TTCAGATGGATGAAGGAGAGGATCCTAGCTTCCTGTTCCAGTCATACCTGGA

A A AT GTT GGAGTCC A A AT AGT C AG AC A A AT GAGGT C AGGAGAGAGATTTC T C

AAGATATGGTCACAGACCGTAGAAGAGATTATATCCTATGTCGCGGTCAACT

TTCCCAACCCTCCAGGAAAGTCTTCAGAGGATAAATCAACCCAGACTACTGG

CCGAGAGCTCAAGAAGGAGACAACACCCACTCCTTCTCAGAGAGAAAGCCA

ATCATCGAAAGCCAGGATGGCGGCTCAAATTGCTTCTGGCCCTCCAGCCCTTG

AAT GGT C GGCT AC C A AT GA AGAGGAT GAT C T AT C AGT GGAGGC T GAGAT C GC

TCACCAGATTGCAGAAAGTTTCTCCAAAAAATATAAGTTTCCCTCTCGATCCT

CAGGGATACTCTTGTATAATTTTGAGCAATTGAAAATGAACCTTGATGATATA

GTTAAAGAGGCAAAAAATGTACCAGGTGTGACCCGTTTAGCCCATGACGGGT

CCAAACTCCCCCTAAGATGTGTACTGGGATGGGTCGCTTTGGCCAACTCTAAG

AAATTCC AGTTGTT AGTCGAATCCGAC AAGCTGAGT AAAAT CAT GC AAGAT G

ACTTGAATCGCTATACATCTTGCTAACCGAACCTCTCCCCTCAGTCCCTCTAG

AC A AT A A A ATCC GAGAT GT C CCA A AGT C A AC AT GA A A A A A AC AGGC A AC AC

CACTGATAAAATGAACCTCCTACGT AAGAT AGTGAAAAACCGCAGGGACGAG

GACACTCAAAAATCCTCTCCCGCGTCAGCCCCTCTGGATGACGATGACTTGTG GCTTCCACCCCCTGAATACGTCCCGCTGAAAGAACTTACAGGCAAGAAGAAC

ATGAGGAACTTTTGTATCAACGGAAGGGTTAAAGTGTGTAGCCCGAATGGTT

ACTCGTTCAGGATCCTGCGGCACATTCTGAAATCATTCGACGAGATATATTCT

GGGAATCATAGGATGATCGGGTTAGTCAAAGTGGTTATTGGACTGGCTTTGTC

AGGATCTCCAGTCCCTGAGGGCCTGAACTGGGTATACAAATTGAGGAGAACC

TTTATCTTCCAGTGGGCTGATTCCAGGGGCCCTCTTGAAGGGGAGGAGTTGGA

ATACTCTCAGGAGATCACTTGGGATGATGATACTGAGTTCGTCGGATTGCAA

AT A AGAGT GATT GC A A A AC AGT GTC AT ATCC AGGGC AGAGT C T GGT GT ATC A

ACATGAACCCGAGAGCATGTCAACTATGGTCTGACATGTCTCTTCAGACACA

AAGGTCCGAAGAGGAC AAAGATTCCTCTCTGCTTCT AGAAT AAT C AG ATT AT

ATCCCGCAAATTTATCACTTGTTTACCTCTGGAGGAGAGAACATATGGGCTCA

ACTCC AACCCTT GGGAGC AAT AT AAC AAAAAAC ATGTT AT GGT GCC ATT AAA

CCGCTGCATTTCATCAAAGTCAAGTTGATTACCTTTACATTTTGATCCTCTTGG

AT GTGAA AAAAACT ATT AAC ATCCCTC AAAAGACcccggg AAAGATGGTTCCTC

AGGCTCTCCTGTTTGTACCCCTTCTGGTTTTTCCATTGTGTTTTGGGAAATTCC

CTATTTACACGATACCAGACAAGCTTGGTCCCTGGAGTCCGATTGACATACAT

CACCTCAGCTGCCCAAACAATTTGGTAGTGGAGGACGAAGGATGCACCAACC

TGTCAGGGTTCTCCTACATGGAACTTAAAGTTGGATACATCTTAGCCATAAAA

GTGAACGGGTTCACTTGCACAGGCGTTGTGACGGAGGCTGAAACCTACACTA

ACTTCGTTGGTTATGTCACAACCACGTTCAAAAGAAAGCATTTCCGCCCAACA

CCAGATGCATGTAGAGCCGCGTACAACTGGAAGATGGCCGGTGACCCCAGAT

ATGAAGAGTCTCTACACAATCCGTACCCTGACTACCGCTGGCTTCGAACTGTA

AAAACCACCAAGGAGTCTCTCGTTATCATATCTCCAAGTGTGGCAGATTTGGA

CCCATATGACAGATCCCTTCACTCGAGGGTCTTCCCTAGCGGGAAGTGCTCAG

GAGTAGCGGTGTCTTCTACCTACTGCTCCACTAACCACGATTACACCATTTGG

ATGCCCGAGAATCCGAGACTAGGGATGTCTTGTGACATTTTTACCAATAGTAG

AGGGAAGAGAGC ATCC AAAGGG AGT GAGACTT GCGGCTTTGT AG AT GAAAG

AGGCCTATATAAGTCTTTAAAAGGAGCATGCAAACTCAAGTTATGTGGAGTT

CT AGGAC TT AGACTT AT GGAT GGA AC AT GGGT C TC GAT GCA A AC AT C A A AT G

AAACCAAATGGTGCCCTCCCGATAAGTTGGTGAACCTGCACGACTTTCGCTCA

GAC GA A ATT GAGC AC CTTGTTGT AGAGGAGTT GGT C AGG A AGAGAGAGGAGT

GTCTGGATGCACTAGAGTCCATCATGACAACCAAGTCAGTGAGTTTCAGACG

TCTCAGTCATTTAAGAAAACTTGTCCCTGGGTTTGGAAAAGCATATACCATAT

TCAACAAGACCTTGATGGAAGCCGATGCTCACTACAAGTCAGTCgagACTTGG AATGAGATCCTCCCTTCAAAAGGGTGTTTAAGAGTTGGGGGGAGGTGTCATC

CTC AT GTGAACGGGGT GTTTTT C AAT GGT AT AAT ATT AGGACCTGACGGC AAT

GTCTTAATCCCAGAGATGCAATCATCCCTCCTCCAGCAACATATGGAGTTGTT

GGAATCCTCGGTTATCCCCCTTGTGCACCCCCTGGCAGACCCGTCTACCGTTT

TCAAGGACGGTGACGAGGCTGAGGATTTTGTTGAAGTTCACCTTCCCGATGTG

C AC AAT C AGGTCTC AGGAGTTGACTT GGGTCTCCCGAACTGGGGGAAGT AT G

TATTACTGAGTGCAGGGGCCCTGACTGCCTTGATGTTGATAATTTTCCTGATG

ACATGTTGTAGAAGAGTCAATCGATCAGAACCTACGCAACACAATCTCAGAG

GGACAGGGAGGGAGGTGTCAGTCACTCCCCAAAGCGGGAAGATCATATCTTC

AT GGG A AT C AC AC A AG AGT GGGGGT GAG AC C AG AC T GT A AttaattaaC GT C C T TT

CAACGATCCAAGTCcatgaaaaaaactaacacccctcccgtacctagcTTATAAAGTGCTGGGTC

ATCTAAGCTTTTCAGTCGAGAAAAAAACATTAGATCAGAAGAACAACTGGCA

ACACTTCTCAACCTGAGACTTACTTCAAGATGCTCGATCCTGGAGAGGTCTAT

GATGACCCTATTGACCCAATCGAGTTAGAGGCTGAACCCAGAGGAACCCCCA

TTGTCCCCAACATCTTGAGGAACTCTGACTACAATCTCAACTCTCCTTTGATA

GAAGATCCTGCTAGACTAATGTTAGAATGGTTAAAAACAGGGAATAGACCTT

ATCGGATGACTCTAACAGACAATTGCTCCAGGTCTTTCAGAGTTTTGAAAGAT

T ATTTC A AGAAGGT AGATTT GGGTTCTCTC AAGGTGGGCGGAAT GGCTGC AC

AGTCAATGATTTCTCTCTGGTTATATGGTGCCCACTCTGAATCCAACAGGAGC

CGGAGATGTATAACAGACTTGGCCCATTTCTATTCCAAGTCGTCCCCCATAGA

GAAGCTGTTGAATCTCACGCTAGGAAATAGAGGGCTGAGAATCCCCCCAGAG

GGAGTGTTAAGTTGCCTTGAGAGGGTTGATTATGATAATGCATTTGGAAGGTA

TCTTGCCAACACGTATTCCTCTTACTTGTTCTTCCATGTAATCACCTTATACAT

GAACGCCCTAGACTGGGATGAAGAAAAGACCATCCTAGCATTATGGAAAGAT

TT AACCTC AGT GGAC ATCGGGA AGGACTT GGT AAAGTT C AAAGACC AAAT AT

GGGGACTGCTGATCGTGACAAAGGACTTTGTTTACTCCCAAAGTTCCAATTGT

CTTTTTGACAGAAACTACACACTTATGCTAAAAGATCTTTTCTTGTCTCGCTTC

AACTCCTTAATGGTCTTGCTCTCTCCCCCAGAGCCCCGATACTCAGATGACTT

GATATCTCAACTATGCCAGCTGTACATTGCTGGGGATCAAGTCTTGTCTATGT

GT GGAAACTCCGGCT ATGAAGTC AT C AAAAT ATT GGAGCC AT AT GTCGT GAA

TAGTTTAGTCCAGAGAGCAGAAAAGTTTAGGCCTCTCATTCATTCCTTGGGAG

ACTTTCCTGT ATTT AT AAAAGAC AAGGT AAGT C AACTT GAAGAGACGTTCGGT

CCCTGTGCAAGAAGGTTCTTTAGGGCTCTGGATCAATTCGACAACATACATGA

CTTGGTTTTTGTGTTTGGCTGTTACAGGCATTGGGGGCACCCATATATAGATT ATCGAAAGGGTCTGTCAAAACTATATGATCAGGTTCACCTTAAAAAAATGAT

AGATAAGTCCTACCAGGAGTGCTTAGCAAGCGACCTAGCCAGGAGGATCCTT

AGATGGGGTTTTGATAAGTACTCCAAGTGGTATCTGGATTCAAGATTCCTAGC

CCGAGACCACCCCTTGACTCCTTATATCAAAACCCAAACATGGCCACCCAAA

CATATTGTAGACTTGGTGGGGGATACATGGCACAAGCTCCCGATCACGCAGA

TCTTTGAGATTCCTGAATCAATGGATCCGTCAGAAATATTGGATGACAAATCA

CATTCTTTCACCAGAACGAGACTAGCTTCTTGGCTGTCAGAAAACCGAGGGG

GGCCTGTTCCTAGCGAAAAAGTTATTATCACGGCCCTGTCTAAGCCGCCTGTC

AATCCCCGAGAGTTTCTGAGGTCTATAGACCTCGGAGGATTGCCAGATGAAG

ACTTGATAATTGGCCTCAAGCCAAAGGAACGGGAATTGAAGATTGAAGGTCG

ATTCTTTGCTCTAATGTCATGGAATCTAAGATTGTATTTTGTCATCACTGAAAA

ACTCTTGGCCAACTACATCTTGCCACTTTTTGACGCGCTGACTATGACAGACA

ACCTGAACAAGGTGTTTAAAAAGCTGATCGACAGGGTCACCGGGCAAGGGCT

TTTGGACTATTCAAGGGTCACATATGCATTTCACCTGGACTATGAAAAGTGGA

ACAACCATCAAAGATTAGAGTCAACAGAGGATGTATTTTCTGTCCTAGATCA

AGT GTTTGGATT GAAGAGAGT GTTTTCT AGAAC AC ACGAGTTTTTT C AAAAGG

CCTGGATCTATTATTCAGACAGATCAGACCTCATCGGGTTACGGGAGGATCA

AATATACTGCTTAGATGCGTCCAACGGCCCAACCTGTTGGAATGGCCAGGAT

GGCGGGCTAGAAGGCTTACGGCAGAAGGGCTGGAGTCTAGTCAGCTTATTGA

T GAT AGAT AGAGAATCTC AA ATC AGGAAC AC AAGAACC AAAAT ACT AGCTC A

AGGAGACAACCAGGTTTTATGTCCGACATACATGTTGTCGCCAGGGCTATCTC

AAGAGGGGCTCCTCTATGAATTGGAGAGAATATCAAGGAATGCACTTTCGAT

AT AC AG AGC C GT C G AGG A AGGGGC AT C T A AGC T AGGGC T GAT CATC A AG A A

AGAAGAGACCATGTGTAGTTATGACTTCCTCATCTATGGAAAAACCCCTTTGT

TT AGAGGT AAC AT ATT GGT GCCTGAGTCC AAAAGAT GGGCC AGAGTCTCTTG

CGTCTCTAATGACCAAATAGTCAACCTCGCCAATATAATGTCGACAGTGTCCA

CCAATGCGCTAACAGTGGCACAACACTCTCAATCTTTGATCAAACCGATGAG

GGATTTTCTGCTCATGTCAGTACAGGCAGTCTTTCACTACCTGCTATTTAGCCC

AATCTT AAAGGGA AGAGTTT AC AAGATTCTGAGCGCTGAAGGGGAGAGCTTT

CTCCTAGCCATGTCAAGGATAATCTATCTAGATCCTTCTTTGGGAGGGATATC

TGGAATGTCCCTCGGAAGATTCCATATACGACAGTTCTCAGACCCTGTCTCTG

AAGGGTTATCCTTCTGGAGAGAGATCTGGTTAAGCTCCCAAGAGTCCTGGATT

C ACGCGTTGT GT C AAGAGGCTGGAAACCC AGATCTTGGAGAGAGAAC ACTCG

AGAGCTTCACTCGCCTTCTAGAAGATCCGACCACCTTAAATATCAGAGGAGG GGCCAGTCCTACCATTCTACTCAAGGATGCAATCAGAAAGGCTTTATATGAC

GAGGT GGAC AAGGTGGA AAATT C AGAGTTTCGAGAGGC AATCCTGTT GTCC A

AGACCCATAGAGATAATTTTATACTCTTCTTAATATCTGTTGAGCCTCTGTTTC

CTCGATTTCTCAGTGAGCTATTCAGTTCGTCTTTTTTGGGAATCCCCGAGTCAA

TCATTGGATTGATACAAAACTCCCGAACGATAAGAAGGCAGTTTAGAAAGAG

TCTCTCAAAAACTTTAGAAGAATCCTTCTACAACTCAGAGATCCACGGGATTA

GTCGGATGACCCAGACACCTCAGAGGGTTGGGGGGGTGTGGCCTTGCTCTTC

AGAGAGGGC AGATCT ACTT AGGGAGATCTCTT GGGGAAGAAAAGT GGT AGG

CACGACAGTTCCTCACCCTTCTGAGATGTTGGGATTACTTCCCAAGTCCTCTA

TTTCTTGCACTTGTGGAGCAACAGGAGGAGGCAATCCTAGAGTTTCTGTATCA

GTACTCCCGTCCTTTGATCAGTCATTTTTTTCACGAGGCCCCCTAAAGGGATA

CTTGGGCTCGTCCACCTCTATGTCGACCCAGCTATTCCATGCATGGGAAAAAG

T C ACT A AT GTT CAT GT GGT GA AGAGAGCTCT AT C GTT A A A AGA ATCT AT A A AC

TGGTTCATTACTAGAGATTCCAACTTGGCTCAAGCTCTAATTAGGAACATTAT

GTCTCTGACAGGCCCTGATTTCCCTCTAGAGGAGGCCCCTGTCTTCAAAAGGA

CGGGGTCAGCCTTGCATAGGTTCAAGTCTGCCAGATACAGCGAAGGAGGGTA

TTCTTCTGTCTGCCCGAACCTCCTCTCTCATATTTCTGTTAGTACAGACACCAT

GTCTGATTTGACCCAAGACGGGAAGAACTACGATTTCATGTTCCAGCCATTGA

TGCTTTATGCACAGACATGGACATCAGAGCTGGTACAGAGAGACACAAGGCT

AAGAGACTCTACGTTTCATTGGCACCTCCGATGCAACAGGTGTGTGAGACCC

ATTGACGACGTGACCCTGGAGACCTCTCAGATCTTCGAGTTTCCGGATGTGTC

GAAAAGAATATCCAGAATGGTTTCTGGGGCTGTGCCTCACTTCCAGAGGCTTC

CCGATATCCGTCTGAGACCAGGAGATTTTGAATCTCTAAGCGGTAGAGAAAA

GTCTCACCATATCGGATCAGCTCAGGGGCTCTTATACTCAATCTTAGTGGCAA

TTCACGACTCAGGATACAATGATGGAACCATCTTCCCTGTCAACATATACGGC

AAGGTTTCCCCT AGAGACT ATTT GAGAGGGCTCGC AAGGGGAGT ATT GAT AG

GATCCTCGATTTGCTTCTTGACAAGAATGACAAATATCAATATTAATAGACCT

CTTGAATTGGTCTCAGGGGTAATCTCATATATTCTCCTGAGGCTAGATAACCA

TCCCTCCTTGTACATAATGCTCAGAGAACCGTCTCTTAGAGGAGAGATATTTT

CTATCCCTCAGAAAATCCCCGCCGCTTATCCAACCACTATGAAAGAAGGCAA

CAGATCAATCTTGTGTTATCTCCAACATGTGCTACGCTATGAGCGAGAGATAA

TCACGGCGTCTCCAGAGAATGACTGGCTATGGATCTTTTCAGACTTTAGAAGT

GCCAAAATGACGTACCTATCCCTCATTACTTACCAGTCTCATCTTCTACTCCA

GAGGGTTGAGAGAAACCTATCTAAGAGTATGAGAGATAACCTGCGACAATTG AGTTCTTTGATGAGGCAGGTGCTGGGCGGGCACGGAGAAGATACCTTAGAGT

CAGACGACAACATTCAACGACTGCTAAAAGACTCTTTACGAAGGACAAGATG

GGT GGATC AAGAGGT GCGCC ATGC AGCT AGAACC AT GACTGGAGATT AC AGC

CCCAACAAGAAGGTGTCCCGTAAGGTAGGATGTTCAGAATGGGTCTGCTCTG

CTCAACAGGTTGCAGTCTCTACCTCAGCAAACCCGGCCCCTGTCTCGGAGCTT

GACATAAGGGCCCTCTCTAAGAGGTTCCAGAACCCTTTGATCTCGGGCTTGAG

AGTGGTTCAGTGGGCAACCGGTGCTCATTATAAGCTTAAGCCTATTCTAGATG

ATCTCAATGTTTTCCCATCTCTCTGCCTTGTAGTTGGGGACGGGTCAGGGGGG

ATATCAAGGGCAGTCCTCAACATGTTTCCAGATGCCAAGCTTGTGTTCAACAG

TCTTTTAGAGGTGAATGACCTGATGGCTTCCGGAACACATCCACTGCCTCCTT

CAGCAATCATGAGGGGAGGAAATGATATCGTCTCCAGAGTGATAGATCTTGA

CTCAATCTGGGAAAAACCGTCCGACTTGAGAAACTTGGCAACCTGGAAATAC

TTCCAGTCAGTCCAAAAGCAGGTCAACATGTCCTATGACCTCATTATTTGCGA

TGCAGAAGTTACTGACATTGCATCTATCAACCGGATCACCCTGTTAATGTCCG

ATTTTGCATTGTCTATAGATGGACCACTCTATTTGGTCTTCAAAACTTATGGG

ACTATGCTAGTAAATCCAAACTACAAGGCTATTCAACACCTGTCAAGAGCGT

TCCCCTCGGTCACAGGGTTTATCACCCAAGTAACTTCGTCTTTTTCATCTGAGC

TCTACCTCCGATTCTCCAAACGAGGGAAGTTTTTCAGAGATGCTGAGTACTTG

ACCTCTTCCACCCTTCGAGAAATGAGCCTTGTGTTATTCAATTGTAGCAGCCC

CAAGAGTGAGATGCAGAGAGCTCGTTCCTTGAACTATCAGGATCTTGTGAGA

GGATTTCCTGAAGAAATCATATCAAATCCTTACAATGAGATGATCATAACTCT

GATTGAC AGT GATGT AGAATCTTTTCT AGTCC AC AAGAT GGTT GAT GATCTT G

AGTTACAGAGGGGAACTCTGTCTAAAGTGGCTATCATTATAGCCATCATGAT

AGTTTTCTCCAACAGAGTCTTCAACGTTTCCAAACCCCTAACTGACCCCTCGT

TCTATCCACCGTCTGATCCCAAAATCCTGAGGCACTTCAACATATGTTGCAGT

ACTATGATGTATCTATCTACTGCTTTAGGTGACGTCCCTAGCTTCGCAAGACT

TCACGACCTGTATAACAGACCTATAACTTATTACTTCAGAAAGCAAGTCATTC

GAGGGA AC GTTT AT C T ATCTTGGAGTT GGT C C A AC GAC AC CTC AGT GTT C A A A

AGGGTAGCCTGTAATTCTAGCCTGAGTCTGTCATCTCACTGGATCAGGTTGAT

TTAC AAGAT AGTGAAGACTACCAGACTCGTTGGCAGCATCAAGGATCTATCC

AGAGAAGTGGAAAGACACCTTCATAGGTACAACAGGTGGATCACCCTAGAG

GATATCAGATCTAGATCATCCCTACTAGACTACAGTTGCCTGTGAACCGGATA

CTCCTGGAAGCCTGCCCATGCTAAGACTCTTGTGTGATGTATCTTGAAAAAAA CAAGATCCTAAATCTGAACCTTTGGTTGTTTGATTGTTTTTCTCAtttttgttgtttatttgtt aagcgt.

In another embodiment, the nucleic acid comprises the sequence of SEQ ID NO:

7, shown below (RABV vector: Coravax Vl-South Africa (RABVG-E31)):

ACGCTTAACAACCAGATCAAAGAAAAAACAGACATTGTCAATTGCAAAGCAA

AAATGTAACACCCCTACAATGGATGCCGACAAGATTGTATTCAAAGTCAATA

AT C AGGT GGT C TC TT T G A AGC C T GAG AT T AT C GT GG AT C A AT AT G AGT AC A AG

TACCCTGCCATCAAAGATTTGAAAAAGCCCTGTATAACCCTAGGAAAGGCTC

CCGATTTAAATAAAGCATACAAGTCAGTTTTGTCAGGCATGAGCGCCGCCAA

ACTTAATCCTGACGATGTATGTTCCTATTTGGCAGCGGCAATGCAGTTTTTTG

AGGGGACATGTCCGGAAGACTGGACCAGCTATGGAATTGTGATTGCACGAAA

AGGAGATAAGATCACCCCAGGTTCTCTGGTGGAGATAAAACGTACTGATGTA

GAAGGGAATT GGGCTCTGAC AGGAGGC AT GGAACTGAC AAGAGACCCC ACT

GTCCCTGAGCATGCGTCCTTAGTCGGTCTTCTCTTGAGTCTGTATAGGTTGAG

CAAAATATCCGGGCAAAACACTGGTAACTATAAGACAAACATTGCAGACAGG

ATAGAGCAGATTTTTGAGACAGCCCCTTTTGTTAAAATCGTGGAACACCATAC

TC T A AT GAC A AC TC AC A Aa AT GT GT GCT A ATT GGAGT ACT AT AC C A A AC TTC A

GATTTTTGGCCGGAACCTATGACATGTTTTTCTCCCGGATTGAGCATCTATATT

CAGCAATCAGAGTGGGCACAGTTGTCACTGCTTATGAAGACTGTTCAGGACT

GGTATCATTTACTGGGTTCATAAAACAAATCAATCTCACCGCTAGAGAGGCA

ATACTATATTTCTTCCACAAGAACTTTGAGGAAGAGATAAGAAGAATGTTTG

AGCCAGGGCAGGAGACAGCTGTTCCTCACTCTTATTTCATCCACTTCCGTTCA

CTAGGCTTGAGTGGGAAATCTCCTTATTCATCAAATGCTGTTGGTCACGTGTT

CAATCTCATTCACTTTGTAGGATGCTATATGGGTCAAGTCAGATCCCTAAATG

CAACGGTTATTGCTGCATGTGCTCCTCATGAAATGTCTGTTCTAGGGGGCTAT

CTGGGAGAGGAATTCTTCGGGAAAGGGAC ATTTGAAAGAAGATTCTTC AGAG

AT GAG A A AG A AC TT C A AG A AT AC G AGGC GGC T G A AC T GAC A A AG AC T GAC G

TAGCACTGGCAGATGATGGAACTGTCAACTCTGACGACGAGGACTACTTTTC

AGGT GAAACC AGAAGTCCGGAGGCTGTTT AT ACTCGAAT CAT GAT GAAT GGA

GGTCGACTAAAGAGATCTCACATACGGAGATATGTCTCAGTCAGTTCCAATC

ATCAAGCCCGTCCAAACTCATTCGCCGAGTTTCTAAACAAGACATATTCGAGT

GACTCATAAcatgaaaaaaactaacacccctcccGTACGCCACCATGTTCGTGTTTCTGGTG

CTGCTGCCTCTGGTGAGCTCCCAGTGCGTGAACTTCACCACAAGGACCCAGCT

GCCCCCTGCCTATACCAATTCCTTCACACGGGGCGTGTACTATCCCGACAAGG TGTTCCGGAGCAGCGTGCTGCACTCCACACAGGATCTGTTTCTGCCTTTCTTTT

CTAACGTGACCTGGTTCCACGCCATCCACGTGAGCGGCACCAATGGCACAAA

GCGGTTCGCCAATCCAGTGCTGCCCTTTAACGATGGCGTGTACTTCGCCTCCA

CCGAGAAGTCTAACATCATCAGAGGCTGGATCTTTGGCACCACACTGGACAG

CAAGACACAGTCCCTGCTGATCGTGAACAATGCCACCAACGTGGTCATCAAG

GTGTGCGAGTTCCAGTTTTGTAATGATCCATTCCTGGGCGTGTACTATCACAA

GAACAATAAGTCTTGGATGGAGAGCGAGTTTCGCGTGTATTCCTCTGCCAAC

AATTGCACATTTGAGTACGTGTCCCAGCCCTTCCTGATGGACCTGGAGGGCAA

GC AGGGC AATTT C AAGAACCTGAGGGAGTTCGT GTTT AAGAAT ATCGAT GGC

TACTTCAAAATCTACTCCAAGCACACCCCAATCAACCTGGTGCGCGGCCTGCC

ACAGGGCTTCTCTGCCCTGGAGCCACTGGTGGATCTGCCCATCGGCATCAACA

TCACCCGGTTTCAGACACTGCTGGCCCTGCACAGAAGCTACCTGACACCAGG

CGACAGCTCCTCTGGATGGACCGCAGGAGCAGCAGCCTACTATGTGGGCTAT

CTGCAGCCCAGGACCTTCCTGCTGAAGTACAACGAGAATGGCACCATCACAG

ACGCCGTGGATTGCGCCCTGGATCCCCTGTCTGAGACCAAGTGTACACTGAA

GAGCTTTACCGTGGAGAAGGGCATCTATCAGACAAGCAATTTCAGGGTGCAG

CCTACCGAGTCCATCGTGCGCTTTCCCAATATCACAAACCTGTGCCCTTTTGG

CGAGGTGTTCAACGCAACCCGCTTCGCCAGCGTGTACGCCTGGAATAGGAAG

CGCATCTCCAACTGCGTGGCCGACTATTCTGTGCTGTACAACAGCGCCTCCTT

CTCTACCTTTAAGTGCTATGGCGTGAGCCCCACAAAGCTGAATGACCTGTGCT

TTACCAACGTGTACGCCGATTCCTTCGTGATCAGGGGCGACGAGGTGCGCCA

GATCGC ACC AGGAC AGAC AGGC AAT ATCGC AGACT AC AATT AT AAGCTGCCT

GACGATTTCACCGGCTGCGTGATCGCCTGGAACTCTAACAATCTGGATAGCA

AAGTGGGCGGCAACTACAATTATCTGTACCGGCTGTTTAGAAAGTCTAATCTG

AAGCCATTCGAGAGGGACATCTCCACAGAAATCTACCAGGCCGGCTCTACCC

CCTGCAATGGCGTGAAGGGCTTTAACTGTTATTTCCCTCTGCAGAGCTACGGC

TTCCAGCCAACATATGGCGTGGGCTATCAGCCCTACCGCGTGGTGGTGCTGTC

TTTTGAGCTGCTGCACGCACCTGCAACAGTGTGCGGACCAAAGAAGAGCACC

A ATCTGGT GA AGA AC A AGT GCGT GA AC TT C A AC TT C A AC GGACTGACC GGA A

CAGGCGTGCTGACCGAGTCCAACAAGAAGTTCCTGCCTTTTCAGCAGTTCGGC

AGGGACATCGCAGATACCACAGACGCCGTGCGCGACCCTCAGACCCTGGAGA

TCCTGGACATCACACCATGCTCCTTCGGCGGCGTGTCTGTGATCAC ACC AGGC

ACCAATACAAGCAACCAGGTGGCCGTGCTGTATCAGGGCGTGAATTGTACCG

AGGTGCCAGTGGCAATCCACGCAGATCAGCTGACCCCTACATGGCGGGTGTA CTCTACCGGCAGCAACGTGTTCCAGACAAGAGCCGGATGCCTGATCGGAGCA

GAGCACGTGAACAATAGCTATGAGTGCGACATCCCTATCGGCGCCGGCATCT

GTGCCTCCTACCAGACCCAGACAAACTCCCCaagGTCTGTGGGAGATGAGGCC

GAAGACTTTGTGGAAGTCCACCTGCCTGATGTGCATAACCAGGTGTCTGGCGT

CGACCTGGGACTGCCAAATTGGGGCAAGTACGTGCTGCTGAGTGCTGGAGCA

CTGACTGCCCTGATGCTGATCATTTTCCTGATGACCTGCTGTCGGCGCGTGAA

C AGAAGTGAGCCC ACTC AGC AC AATCTGCGAGGAACCGGGAGAGAAGT GT C

AGT C AC ACCTC AGAGCGGGAAAAT C ATT AGT AGTTGGGAAT C AC AT AAAAGC

GGGGGCGAGACCAGGCTGTGAGCTAGCCATGAAAAAAACTAACACCCCTCCT

TTCGAACCATCCCAAACATGAGCAAGATCTTTGTCAATCCTAGTGCTATTAGA

GCCGGTCTGGCCGATCTTGAGATGGCTGAAGAAACTGTTGATCTGATCAATA

GAAAT ATCGAAGAC AATC AGGCTC ATCTCC AAGGGGAACCC AT AGAGGTGGA

CAATCTCCCTGAGGATATGGGGCGACTTCACCTGGATGATGGAAAATCGCCC

AACC AT GGT GAG AT AGCC AAGGTGGGAGAAGGC A AGT ATCGAGAGGACTTT

C AGATGGAT GAAGGAGAGGATCCT AGCTTCCTGTTCC AGT CAT ACCTGGAAA

AT GTT GGAGTCC AA AT AGT C AGAC AAAT GAGGT C AGGAGAGAGATTTCTC AA

GATATGGTCACAGACCGTAGAAGAGATTATATCCTATGTCGCGGTCAACTTTC

CCAACCCTCCAGGAAAGTCTTCAGAGGATAAATCAACCCAGACTACTGGCCG

AGAGCTCAAGAAGGAGACAACACCCACTCCTTCTCAGAGAGAAAGCCAATCA

TCGAAAGCCAGGATGGCGGCTCAAATTGCTTCTGGCCCTCCAGCCCTTGAATG

GTCGGCTACCAATGAAGAGGATGATCTATCAGTGGAGGCTGAGATCGCTCAC

CAGATTGCAGAAAGTTTCTCCAAAAAATATAAGTTTCCCTCTCGATCCTCAGG

GAT ACTCTTGT AT A ATTTT GAGC A ATT GAAAAT GAACCTT GATGAT AT AGTT A

AAGAGGCAAAAAATGTACCAGGTGTGACCCGTTTAGCCCATGACGGGTCCAA

ACTCCCCCTAAGATGTGTACTGGGATGGGTCGCTTTGGCCAACTCTAAGAAAT

TCC AGTTGTT AGTCGAATCCGAC AAGCTGAGT AAAAT CAT GC AAGATGACTT

GAATCGCTATACATCTTGCTAACCGAACCTCTCCCCTCAGTCCCTCTAGACAA

TAAAATCCGAGATGTCCCAAAGTCAACATGAAAAAAACAGGCAACACCACTG

ATAAAATGAACCTCCTACGTAAGATAGTGAAAAACCGCAGGGACGAGGACA

CTCAAAAATCCTCTCCCGCGTCAGCCCCTCTGGATGACGATGACTTGTGGCTT

CCACCCCCTGAATACGTCCCGCTGAAAGAACTTACAGGCAAGAAGAACATGA

GGAACTTTTGTATCAACGGAAGGGTTAAAGTGTGTAGCCCGAATGGTTACTC

GTTCAGGATCCTGCGGCACATTCTGAAATCATTCGACGAGATATATTCTGGGA

ATCATAGGATGATCGGGTTAGTCAAAGTGGTTATTGGACTGGCTTTGTCAGGA TCTCCAGTCCCTGAGGGCCTGAACTGGGTATACAAATTGAGGAGAACCTTTAT

CTTCCAGTGGGCTGATTCCAGGGGCCCTCTTGAAGGGGAGGAGTTGGAATAC

TCTCAGGAGATCACTTGGGATGATGATACTGAGTTCGTCGGATTGCAAATAA

GAGTGATTGCAAAACAGTGTCATATCCAGGGCAGAGTCTGGTGTATCAACAT

GAACCCGAGAGCATGTCAACTATGGTCTGACATGTCTCTTCAGACACAAAGG

TCCGAAGAGGACAAAGATTCCTCTCTGCTTCTAGAATAATCAGATTATATCCC

GCAAATTTATCACTTGTTTACCTCTGGAGGAGAGAACATATGGGCTCAACTCC

AACCCTTGGGAGCAATATAACAAAAAACATGTTATGGTGCCATTAAACCGCT

GCATTTCATCAAAGTCAAGTTGATTACCTTTACATTTTGATCCTCTTGGATGTG

AAAAAAACT ATT AAC ATCCCTC AAAAGACcccggg AAAGAT GGTTCCTC AGGCT

CTCCTGTTTGTACCCCTTCTGGTTTTTCCATTGTGTTTTGGGAAATTCCCTATTT

AC AC GAT ACC AG AC A AGC TT GGT C CC T GGAGTCC GATT GAC AT AC AT C AC CT

CAGCTGCCCAAACAATTTGGTAGTGGAGGACGAAGGATGCACCAACCTGTCA

GGGTTCTCCTACATGGAACTTAAAGTTGGATACATCTTAGCCATAAAAGTGA

ACGGGTTCACTTGCACAGGCGTTGTGACGGAGGCTGAAACCTACACTAACTT

CGTTGGTTATGTCACAACCACGTTCAAAAGAAAGCATTTCCGCCCAACACCA

GATGCATGTAGAGCCGCGTACAACTGGAAGATGGCCGGTGACCCCAGATATG

AAGAGTCTCTACACAATCCGTACCCTGACTACCGCTGGCTTCGAACTGTAAAA

ACCACCAAGGAGTCTCTCGTTATCATATCTCCAAGTGTGGCAGATTTGGACCC

ATATGACAGATCCCTTCACTCGAGGGTCTTCCCTAGCGGGAAGTGCTCAGGA

GTAGCGGTGTCTTCTACCTACTGCTCCACTAACCACGATTACACCATTTGGAT

GCCCGAGAATCCGAGACTAGGGATGTCTTGTGACATTTTTACCAATAGTAGA

GGGAAGAGAGC ATCC AAAGGGAGT GAGACTT GCGGCTTTGT AGAT GAAAGA

GGCCTATATAAGTCTTTAAAAGGAGCATGCAAACTCAAGTTATGTGGAGTTCT

AGGACTT AGACTT AT GGATGGAAC AT GGGTCTCGAT GC AAAC ATC AAAT GAA

ACCAAATGGTGCCCTCCCGATAAGTTGGTGAACCTGCACGACTTTCGCTCAGA

CGAAATTGAGCACCTTGTTGTAGAGGAGTTGGTCAGGAAGAGAGAGGAGTGT

CTGGATGCACTAGAGTCCATCATGACAACCAAGTCAGTGAGTTTCAGACGTC

TCAGTCATTTAAGAAAACTTGTCCCTGGGTTTGGAAAAGCATATACCATATTC

AACAAGACCTTGATGGAAGCCGATGCTCACTACAAGTCAGTCgagACTTGGAA

TGAGATCCTCCCTTCAAAAGGGTGTTTAAGAGTTGGGGGGAGGTGTCATCCTC

ATGTGAACGGGGTGTTTTTCAATGGTATAATATTAGGACCTGACGGCAATGTC

TTAATCCCAGAGATGCAATCATCCCTCCTCCAGCAACATATGGAGTTGTTGGA

ATCCTCGGTTATCCCCCTTGTGCACCCCCTGGCAGACCCGTCTACCGTTTTCA AGGACGGTGACGAGGCTGAGGATTTTGTTGAAGTTCACCTTCCCGATGTGCA

CAATCAGGTCTCAGGAGTTGACTTGGGTCTCCCGAACTGGGGGAAGTATGTA

TTACTGAGTGCAGGGGCCCTGACTGCCTTGATGTTGATAATTTTCCTGATGAC

AT GTT GT AGAAGAGT C AATCGAT C AGAACCT ACGC AAC AC AATCTC AGAGGG

AC AGGGAGGGAGGT GT C AGTC ACTCCCC AAAGCGGGAAGATC AT ATCTTC AT

GGGAATCACACAAGAGTGGGGGTGAGACCAGACTGTAAttaattaaCGTCCTTTCA

AC GAT C C A AGTCcatgaaaaaaactaacacccctcccgtacctagcTT AT A A AGT GC T GGGT CAT

CT AAGCTTTT C AGTCGAGAAA AAAAC ATT AGATC AGAAGAAC AACTGGC AAC

ACTTCTCAACCTGAGACTTACTTCAAGATGCTCGATCCTGGAGAGGTCTATGA

TGACCCTATTGACCCAATCGAGTTAGAGGCTGAACCCAGAGGAACCCCCATT

GTCCCCAACATCTTGAGGAACTCTGACTACAATCTCAACTCTCCTTTGATAGA

AGATCCTGCTAGACTAATGTTAGAATGGTTAAAAACAGGGAATAGACCTTAT

CGGATGACTCTAACAGACAATTGCTCCAGGTCTTTCAGAGTTTTGAAAGATTA

TTTCAAGAAGGTAGATTTGGGTTCTCTCAAGGTGGGCGGAATGGCTGCACAG

TCAATGATTTCTCTCTGGTTATATGGTGCCCACTCTGAATCCAACAGGAGCCG

GAGATGTATAACAGACTTGGCCCATTTCTATTCCAAGTCGTCCCCCATAGAGA

AGCTGTTGAATCTCACGCTAGGAAATAGAGGGCTGAGAATCCCCCC AGAGGG

AGT GTT A AGTT GCC TT GAGAGGGTTG ATT AT GAT A AT GC ATTTGGA AGGT AT C

TTGCCAACACGTATTCCTCTTACTTGTTCTTCCATGTAATCACCTTATACATGA

ACGCCCTAGACTGGGATGAAGAAAAGACCATCCTAGCATTATGGAAAGATTT

A AC CTC AGT GGAC ATCGGGA AGGAC TT GGT A A AGTTC A A AGAC C A A AT AT GG

GGACTGCTGATCGTGACAAAGGACTTTGTTTACTCCCAAAGTTCCAATTGTCT

TTTTGACAGAAACTACACACTTATGCTAAAAGATCTTTTCTTGTCTCGCTTCA

ACTCCTTAATGGTCTTGCTCTCTCCCCCAGAGCCCCGATACTCAGATGACTTG

ATATCTCAACTATGCCAGCTGTACATTGCTGGGGATCAAGTCTTGTCTATGTG

TGGAAACTCCGGCTATGAAGTCATCAAAATATTGGAGCCATATGTCGTGAAT

AGTTTAGTCCAGAGAGCAGAAAAGTTTAGGCCTCTCATTCATTCCTTGGGAGA

CTTTCCTGTATTTATAAAAGACAAGGTAAGTCAACTTGAAGAGACGTTCGGTC

CCTGTGCAAGAAGGTTCTTTAGGGCTCTGGATCAATTCGACAACATACATGAC

TTGGTTTTTGTGTTTGGCTGTTACAGGCATTGGGGGCACCCATATATAGATTA

TCGAAAGGGTCTGTCAAAACTATATGATCAGGTTCACCTTAAAAAAATGATA

GATAAGTCCTACCAGGAGTGCTTAGCAAGCGACCTAGCCAGGAGGATCCTTA

GAT GGGGTTTT GAT AAGT ACTCC AAGT GGT ATCTGGATT C A AGATTCCT AGCC

CGAGACCACCCCTTGACTCCTTATATCAAAACCCAAACATGGCCACCCAAAC AT ATT GT AGACTTGGT GGGGGAT AC ATGGC AC AAGCTCCCGAT C ACGC AGAT

CTTTGAGATTCCTGAATCAATGGATCCGTCAGAAATATTGGATGACAAATCAC

ATTCTTTCACCAGAACGAGACTAGCTTCTTGGCTGTCAGAAAACCGAGGGGG

GCCTGTTCCTAGCGAAAAAGTTATTATCACGGCCCTGTCTAAGCCGCCTGTCA

ATCCCCGAGAGTTTCTGAGGTCT AT AGACCTCGGAGGATT GCC AGATGAAGA

CTTGATAATTGGCCTCAAGCCAAAGGAACGGGAATTGAAGATTGAAGGTCGA

TTCTTTGCTCTAATGTCATGGAATCTAAGATTGTATTTTGTCATCACTGAAAAA

CTCTTGGCCAACTACATCTTGCCACTTTTTGACGCGCTGACTATGACAGACAA

CCTGAACAAGGTGTTTAAAAAGCTGATCGACAGGGTCACCGGGCAAGGGCTT

TTGGACTATTCAAGGGTCACATATGCATTTCACCTGGACTATGAAAAGTGGA

ACAACCATCAAAGATTAGAGTCAACAGAGGATGTATTTTCTGTCCTAGATCA

AGT GTTTGGATT GAAGAGAGT GTTTTCT AGAAC AC ACGAGTTTTTT C AAAAGG

CCTGGATCTATTATTCAGACAGATCAGACCTCATCGGGTTACGGGAGGATCA

AATATACTGCTTAGATGCGTCCAACGGCCCAACCTGTTGGAATGGCCAGGAT

GGCGGGCTAGAAGGCTTACGGCAGAAGGGCTGGAGTCTAGTCAGCTTATTGA

T GAT AGAT AGAGAATCTC AA ATC AGGAAC AC AAGAACC AAAAT ACT AGCTC A

AGGAGACAACCAGGTTTTATGTCCGACATACATGTTGTCGCCAGGGCTATCTC

AAGAGGGGCTCCTCTATGAATTGGAGAGAATATCAAGGAATGCACTTTCGAT

AT AC AG AGC C GT C G AGG A AGGGGC AT C T A AGC T AGGGC T GAT CATC A AG A A

AGAAGAGACCATGTGTAGTTATGACTTCCTCATCTATGGAAAAACCCCTTTGT

TT AGAGGT AAC AT ATT GGT GCCTGAGTCC AAAAGAT GGGCC AGAGTCTCTTG

CGTCTCTAATGACCAAATAGTCAACCTCGCCAATATAATGTCGACAGTGTCCA

CCAATGCGCTAACAGTGGCACAACACTCTCAATCTTTGATCAAACCGATGAG

GGATTTTCTGCTCATGTCAGTACAGGCAGTCTTTCACTACCTGCTATTTAGCCC

AATCTT AAAGGGA AGAGTTT AC AAGATTCTGAGCGCTGAAGGGGAGAGCTTT

CTCCTAGCCATGTCAAGGATAATCTATCTAGATCCTTCTTTGGGAGGGATATC

TGGAATGTCCCTCGGAAGATTCCATATACGACAGTTCTCAGACCCTGTCTCTG

AAGGGTTATCCTTCTGGAGAGAGATCTGGTTAAGCTCCCAAGAGTCCTGGATT

C ACGCGTTGT GT C AAGAGGCTGGAAACCC AGATCTTGGAGAGAGAAC ACTCG

AGAGCTTCACTCGCCTTCTAGAAGATCCGACCACCTTAAATATCAGAGGAGG

GGCCAGTCCTACCATTCTACTCAAGGATGCAATCAGAAAGGCTTTATATGAC

GAGGT GGAC AAGGTGGA AAATT C AGAGTTTCGAGAGGC AATCCTGTT GTCC A

AGACCCATAGAGATAATTTTATACTCTTCTTAATATCTGTTGAGCCTCTGTTTC

CTCGATTTCTCAGTGAGCTATTCAGTTCGTCTTTTTTGGGAATCCCCGAGTCAA TCATTGGATTGATACAAAACTCCCGAACGATAAGAAGGCAGTTTAGAAAGAG

TCTCTCAAAAACTTTAGAAGAATCCTTCTACAACTCAGAGATCCACGGGATTA

GTCGGATGACCCAGACACCTCAGAGGGTTGGGGGGGTGTGGCCTTGCTCTTC

AGAGAGGGC AGATCT ACTT AGGGAGATCTCTT GGGGAAGAAAAGT GGT AGG

CACGACAGTTCCTCACCCTTCTGAGATGTTGGGATTACTTCCCAAGTCCTCTA

TTTCTTGCACTTGTGGAGCAACAGGAGGAGGCAATCCTAGAGTTTCTGTATCA

GTACTCCCGTCCTTTGATCAGTCATTTTTTTCACGAGGCCCCCTAAAGGGATA

CTTGGGCTCGTCCACCTCTATGTCGACCCAGCTATTCCATGCATGGGAAAAAG

T C ACT A AT GTT CAT GT GGT GA AGAGAGCTCT AT C GTT A A A AGA ATCT AT A A AC

TGGTTCATTACTAGAGATTCCAACTTGGCTCAAGCTCTAATTAGGAACATTAT

GTCTCTGACAGGCCCTGATTTCCCTCTAGAGGAGGCCCCTGTCTTCAAAAGGA

CGGGGTCAGCCTTGCATAGGTTCAAGTCTGCCAGATACAGCGAAGGAGGGTA

TTCTTCTGTCTGCCCGAACCTCCTCTCTCATATTTCTGTTAGTACAGACACCAT

GTCTGATTTGACCCAAGACGGGAAGAACTACGATTTCATGTTCCAGCCATTGA

TGCTTTATGCACAGACATGGACATCAGAGCTGGTACAGAGAGACACAAGGCT

AAGAGACTCTACGTTTCATTGGCACCTCCGATGCAACAGGTGTGTGAGACCC

ATTGACGACGTGACCCTGGAGACCTCTCAGATCTTCGAGTTTCCGGATGTGTC

GAAAAGAATATCCAGAATGGTTTCTGGGGCTGTGCCTCACTTCCAGAGGCTTC

CCGATATCCGTCTGAGACCAGGAGATTTTGAATCTCTAAGCGGTAGAGAAAA

GTCTCACCATATCGGATCAGCTCAGGGGCTCTTATACTCAATCTTAGTGGCAA

TTCACGACTCAGGATACAATGATGGAACCATCTTCCCTGTCAACATATACGGC

AAGGTTTCCCCT AGAGACT ATTT GAGAGGGCTCGC AAGGGGAGT ATT GAT AG

GATCCTCGATTTGCTTCTTGACAAGAATGACAAATATCAATATTAATAGACCT

CTTGAATTGGTCTCAGGGGTAATCTCATATATTCTCCTGAGGCTAGATAACCA

TCCCTCCTTGTACATAATGCTCAGAGAACCGTCTCTTAGAGGAGAGATATTTT

CTATCCCTCAGAAAATCCCCGCCGCTTATCCAACCACTATGAAAGAAGGCAA

CAGATCAATCTTGTGTTATCTCCAACATGTGCTACGCTATGAGCGAGAGATAA

TCACGGCGTCTCCAGAGAATGACTGGCTATGGATCTTTTCAGACTTTAGAAGT

GCCAAAATGACGTACCTATCCCTCATTACTTACCAGTCTCATCTTCTACTCCA

GAGGGTTGAGAGAAACCTATCTAAGAGTATGAGAGATAACCTGCGACAATTG

AGTTCTTTGATGAGGCAGGTGCTGGGCGGGCACGGAGAAGATACCTTAGAGT

CAGACGACAACATTCAACGACTGCTAAAAGACTCTTTACGAAGGACAAGATG

GGT GGATC AAGAGGT GCGCC ATGC AGCT AGAACC AT GACTGGAGATT AC AGC

CCCAACAAGAAGGTGTCCCGTAAGGTAGGATGTTCAGAATGGGTCTGCTCTG CTCAACAGGTTGCAGTCTCTACCTCAGCAAACCCGGCCCCTGTCTCGGAGCTT

GACATAAGGGCCCTCTCTAAGAGGTTCCAGAACCCTTTGATCTCGGGCTTGAG

AGTGGTTCAGTGGGCAACCGGTGCTCATTATAAGCTTAAGCCTATTCTAGATG

ATCTCAATGTTTTCCCATCTCTCTGCCTTGTAGTTGGGGACGGGTCAGGGGGG

ATATCAAGGGCAGTCCTCAACATGTTTCCAGATGCCAAGCTTGTGTTCAACAG

TCTTTTAGAGGTGAATGACCTGATGGCTTCCGGAACACATCCACTGCCTCCTT

CAGCAATCATGAGGGGAGGAAATGATATCGTCTCCAGAGTGATAGATCTTGA

CTCAATCTGGGAAAAACCGTCCGACTTGAGAAACTTGGCAACCTGGAAATAC

TTCCAGTCAGTCCAAAAGCAGGTCAACATGTCCTATGACCTCATTATTTGCGA

TGCAGAAGTTACTGACATTGCATCTATCAACCGGATCACCCTGTTAATGTCCG

ATTTTGCATTGTCTATAGATGGACCACTCTATTTGGTCTTCAAAACTTATGGG

ACTATGCTAGTAAATCCAAACTACAAGGCTATTCAACACCTGTCAAGAGCGT

TCCCCTCGGTCACAGGGTTTATCACCCAAGTAACTTCGTCTTTTTCATCTGAGC

TCTACCTCCGATTCTCCAAACGAGGGAAGTTTTTCAGAGATGCTGAGTACTTG

ACCTCTTCCACCCTTCGAGAAATGAGCCTTGTGTTATTCAATTGTAGCAGCCC

CAAGAGTGAGATGCAGAGAGCTCGTTCCTTGAACTATCAGGATCTTGTGAGA

GGATTTCCTGAAGAAATCATATCAAATCCTTACAATGAGATGATCATAACTCT

GATTGAC AGT GATGT AGAATCTTTTCT AGTCC AC AAGAT GGTT GAT GATCTT G

AGTTACAGAGGGGAACTCTGTCTAAAGTGGCTATCATTATAGCCATCATGAT

AGTTTTCTCCAACAGAGTCTTCAACGTTTCCAAACCCCTAACTGACCCCTCGT

TCTATCCACCGTCTGATCCCAAAATCCTGAGGCACTTCAACATATGTTGCAGT

ACTATGATGTATCTATCTACTGCTTTAGGTGACGTCCCTAGCTTCGCAAGACT

TCACGACCTGTATAACAGACCTATAACTTATTACTTCAGAAAGCAAGTCATTC

GAGGGA AC GTTT AT C T ATCTTGGAGTT GGT C C A AC GAC AC CTC AGT GTT C A A A

AGGGTAGCCTGTAATTCTAGCCTGAGTCTGTCATCTCACTGGATCAGGTTGAT

TTAC AAGAT AGTGAAGACTACCAGACTCGTTGGCAGCATCAAGGATCTATCC

AGAGAAGTGGAAAGACACCTTCATAGGTACAACAGGTGGATCACCCTAGAG

GATATCAGATCTAGATCATCCCTACTAGACTACAGTTGCCTGTGAACCGGATA

CTCCTGGAAGCCTGCCCATGCTAAGACTCTTGTGTGATGTATCTTGAAAAAAA

CAAGATCCTAAATCTGAACCTTTGGTTGTTTGATTGTTTTTCTCAtttttgttgtttatttgtt aagcgt.

In some embodiments, the nucleic acid comprises the sequence of SEQ ID NO: 8, shown below (RABY vector: Coravax V2-China (RABVG-E51)): ACGCTTAACAACCAGATCAAAGAAAAAACAGACATTGTCAATTGCAAAGCAA

AAATGTAACACCCCTACAATGGATGCCGACAAGATTGTATTCAAAGTCAATA

AT C AGGT GGT C TC TT T G A AGC C T GAG AT T AT C GT GG AT C A AT AT G AGT AC A AG

TACCCTGCCATCAAAGATTTGAAAAAGCCCTGTATAACCCTAGGAAAGGCTC

CCGATTTAAATAAAGCATACAAGTCAGTTTTGTCAGGCATGAGCGCCGCCAA

ACTTAATCCTGACGATGTATGTTCCTATTTGGCAGCGGCAATGCAGTTTTTTG

AGGGGACATGTCCGGAAGACTGGACCAGCTATGGAATTGTGATTGCACGAAA

AGGAGATAAGATCACCCCAGGTTCTCTGGTGGAGATAAAACGTACTGATGTA

GAAGGGAATT GGGCTCTGAC AGGAGGC AT GGAACTGAC AAGAGACCCC ACT

GTCCCTGAGCATGCGTCCTTAGTCGGTCTTCTCTTGAGTCTGTATAGGTTGAG

CAAAATATCCGGGCAAAACACTGGTAACTATAAGACAAACATTGCAGACAGG

ATAGAGCAGATTTTTGAGACAGCCCCTTTTGTTAAAATCGTGGAACACCATAC

TC T A AT GAC A AC TC AC A Aa AT GT GT GCT A ATT GGAGT ACT AT AC C A A AC TTC A

GATTTTTGGCCGGAACCTATGACATGTTTTTCTCCCGGATTGAGCATCTATATT

CAGCAATCAGAGTGGGCACAGTTGTCACTGCTTATGAAGACTGTTCAGGACT

GGTATCATTTACTGGGTTCATAAAACAAATCAATCTCACCGCTAGAGAGGCA

ATACTATATTTCTTCCACAAGAACTTTGAGGAAGAGATAAGAAGAATGTTTG

AGCCAGGGCAGGAGACAGCTGTTCCTCACTCTTATTTCATCCACTTCCGTTCA

CTAGGCTTGAGTGGGAAATCTCCTTATTCATCAAATGCTGTTGGTCACGTGTT

CAATCTCATTCACTTTGTAGGATGCTATATGGGTCAAGTCAGATCCCTAAATG

CAACGGTTATTGCTGCATGTGCTCCTCATGAAATGTCTGTTCTAGGGGGCTAT

CTGGGAGAGGAATTCTTCGGGAAAGGGAC ATTTGAAAGAAGATTCTTC AGAG

AT GAG A A AG A AC TT C A AG A AT AC G AGGC GGC T G A AC T GAC A A AG AC T GAC G

TAGCACTGGCAGATGATGGAACTGTCAACTCTGACGACGAGGACTACTTTTC

AGGT GAAACC AGAAGTCCGGAGGCTGTTT AT ACTCGAAT CAT GAT GAAT GGA

GGTCGACTAAAGAGATCTCACATACGGAGATATGTCTCAGTCAGTTCCAATC

ATCAAGCCCGTCCAAACTCATTCGCCGAGTTTCTAAACAAGACATATTCGAGT

GACTCATAAcatgaaaaaaactaacacccctcccgtacgCCACCATGTTCGTGTTTCTGGTGCT

GCTGCCTCTGGTGAGCTCCCAGTGCGTGAACCTGACCACAAGGACCCAGCTG

CCCCCTGCCTATACCAATTCCTTCACACGGGGCGTGTACTATCCCGACAAGGT

GTTCCGGAGCAGCGTGCTGCACTCCACACAGGATCTGTTTCTGCCTTTCTTTTC

TAACGTGACCTGGTTCCACGCCATCCACGTGAGCGGCACCAATGGCACAAAG

CGGTTCGACAATCCAGTGCTGCCCTTTAACGATGGCGTGTACTTCGCCTCCAC

CGAGAAGTCTAACATCATCAGAGGCTGGATCTTTGGCACCACACTGGACAGC AAGACACAGTCCCTGCTGATCGTGAACAATGCCACCAACGTGGTCATCAAGG

TGTGCGAGTTCCAGTTTTGTAATGATCCATTCCTGGGCGTGTACTATCACAAG

AACAATAAGTCTTGGATGGAGAGCGAGTTTCGCGTGTATTCCTCTGCCAACA

ATTGCACATTTGAGTACGTGTCCCAGCCCTTCCTGATGGACCTGGAGGGCAAG

C AGGGC AATTT C AAGAACCTGAGGGAGTTCGT GTTT AAGAAT ATCGATGGCT

ACTTCAAAATCTACTCCAAGCACACCCCAATCAACCTGGTGCGCGACCTGCC

ACAGGGCTTCTCTGCCCTGGAGCCACTGGTGGATCTGCCCATCGGCATCAACA

TCACCCGGTTTCAGACACTGCTGGCCCTGCACAGAAGCTACCTGACACCAGG

CGACAGCTCCTCTGGATGGACCGCAGGAGCAGCAGCCTACTATGTGGGCTAT

CTGCAGCCCAGGACCTTCCTGCTGAAGTACAACGAGAATGGCACCATCACAG

ACGCCGTGGATTGCGCCCTGGATCCCCTGTCTGAGACCAAGTGTACACTGAA

GAGCTTTACCGTGGAGAAGGGCATCTATCAGACAAGCAATTTCAGGGTGCAG

CCTACCGAGTCCATCGTGCGCTTTCCCAATATCACAAACCTGTGCCCTTTTGG

CGAGGTGTTCAACGCAACCCGCTTCGCCAGCGTGTACGCCTGGAATAGGAAG

CGCATCTCCAACTGCGTGGCCGACTATTCTGTGCTGTACAACAGCGCCTCCTT

CTCTACCTTTAAGTGCTATGGCGTGAGCCCCACAAAGCTGAATGACCTGTGCT

TTACCAACGTGTACGCCGATTCCTTCGTGATCAGGGGCGACGAGGTGCGCCA

GATCGCACCAGGACAGACAGGCAAGATCGCAGACTACAATTATAAGCTGCCT

GACGATTTCACCGGCTGCGTGATCGCCTGGAACTCTAACAATCTGGATAGCA

AAGTGGGCGGCAACTACAATTATCTGTACCGGCTGTTTAGAAAGTCTAATCTG

AAGCCATTCGAGAGGGACATCTCCACAGAAATCTACCAGGCCGGCTCTACCC

CCTGCAATGGCGTGGAGGGCTTTAACTGTTATTTCCCTCTGCAGAGCTACGGC

TTCCAGCCAACAAACGGCGTGGGCTATCAGCCCTACCGCGTGGTGGTGCTGT

CTTTTGAGCTGCTGCACGCACCTGCAACAGTGTGCGGACCAAAGAAGAGCAC

CAATCTGGTGAAGAACAAGTGCGTGAACTTCAACTTCAACGGACTGACCGGA

ACAGGCGTGCTGACCGAGTCCAACAAGAAGTTCCTGCCTTTTCAGCAGTTCG

GCAGGGACATCGCAGATACCACAGACGCCGTGCGCGACCCTCAGACCCTGGA

GATCCTGGACATCACACCATGCTCCTTCGGCGGCGTGTCTGTGATCACACCAG

GCACCAATACAAGCAACCAGGTGGCCGTGCTGTATcAGGACGTGAATTGTAC

CGAGGTGCCAGTGGCAATCCACGCAGATCAGCTGACCCCTACATGGCGGGTG

TACTCTACCGGCAGCAACGTGTTCCAGACAAGAGCCGGATGCCTGATCGGAG

CAGAGCACGTGAACAATAGCTATGAGTGCGACATCCCTATCGGCGCCGGCAT

CTGTGCCTCCTACCAGACCCAGACAAACTCCCCAGAATCAAGCGTGATTCCTC

TGGTCCATCCACTGGCAGATCCCTCCACAGTGTTCAAAGACGGAGATGAGGC CGAAGACTTTGTGGAAGTCCACCTGCCTGATGTGCATAACCAGGTGTCTGGC

GTCGACCTGGGACTGCCAAATTGGGGCAAGTACGTGCTGCTGAGTGCTGGAG

CACTGACTGCCCTGATGCTGATCATTTTCCTGATGACCTGCTGTCGGCGCGTG

AACAGAAGTGAGCCCACTCAGCACAATCTGCGAGGAACCGGGAGAGAAGTG

T C AGTC AC ACCTC AGAGCGGGAAAATC ATT AGT AGTT GGGAATC AC AT AAAA

GCGGGGGCGAGACCAGGCTGTGAgctagcCATGAAAAAAACTAACACCCCTCCT

TTCGAACCATCCCAAACATGAGCAAGATCTTTGTCAATCCTAGTGCTATTAGA

GCCGGTCTGGCCGATCTTGAGATGGCTGAAGAAACTGTTGATCTGATCAATA

GAAAT ATCGAAGAC AATC AGGCTC ATCTCC AAGGGGAACCC AT AGAGGTGGA

CAATCTCCCTGAGGATATGGGGCGACTTCACCTGGATGATGGAAAATCGCCC

AACC AT GGT GAG AT AGCC AAGGTGGGAGAAGGC A AGT ATCGAGAGGACTTT

C AGATGGAT GAAGGAGAGGATCCT AGCTTCCTGTTCC AGT CAT ACCTGGAAA

AT GTT GGAGTCC AA AT AGT C AGAC AAAT GAGGT C AGGAGAGAGATTTCTC AA

GATATGGTCACAGACCGTAGAAGAGATTATATCCTATGTCGCGGTCAACTTTC

CCAACCCTCCAGGAAAGTCTTCAGAGGATAAATCAACCCAGACTACTGGCCG

AGAGCTCAAGAAGGAGACAACACCCACTCCTTCTCAGAGAGAAAGCCAATCA

TCGAAAGCCAGGATGGCGGCTCAAATTGCTTCTGGCCCTCCAGCCCTTGAATG

GTCGGCTACCAATGAAGAGGATGATCTATCAGTGGAGGCTGAGATCGCTCAC

CAGATTGCAGAAAGTTTCTCCAAAAAATATAAGTTTCCCTCTCGATCCTCAGG

GAT ACTCTTGT AT A ATTTT GAGC A ATT GAAAAT GAACCTT GATGAT AT AGTT A

AAGAGGCAAAAAATGTACCAGGTGTGACCCGTTTAGCCCATGACGGGTCCAA

ACTCCCCCTAAGATGTGTACTGGGATGGGTCGCTTTGGCCAACTCTAAGAAAT

TCC AGTTGTT AGTCGAATCCGAC AAGCTGAGT AAAAT CAT GC AAGATGACTT

GAATCGCTATACATCTTGCTAACCGAACCTCTCCCCTCAGTCCCTCTAGACAA

TAAAATCCGAGATGTCCCAAAGTCAACATGAAAAAAACAGGCAACACCACTG

ATAAAATGAACCTCCTACGTAAGATAGTGAAAAACCGCAGGGACGAGGACA

CTCAAAAATCCTCTCCCGCGTCAGCCCCTCTGGATGACGATGACTTGTGGCTT

CCACCCCCTGAATACGTCCCGCTGAAAGAACTTACAGGCAAGAAGAACATGA

GGAACTTTTGTATCAACGGAAGGGTTAAAGTGTGTAGCCCGAATGGTTACTC

GTTCAGGATCCTGCGGCACATTCTGAAATCATTCGACGAGATATATTCTGGGA

ATCATAGGATGATCGGGTTAGTCAAAGTGGTTATTGGACTGGCTTTGTCAGGA

TCTCCAGTCCCTGAGGGCCTGAACTGGGTATACAAATTGAGGAGAACCTTTAT

CTTCCAGTGGGCTGATTCCAGGGGCCCTCTTGAAGGGGAGGAGTTGGAATAC

TCTCAGGAGATCACTTGGGATGATGATACTGAGTTCGTCGGATTGCAAATAA GAGTGATTGCAAAACAGTGTCATATCCAGGGCAGAGTCTGGTGTATCAACAT

GAACCCGAGAGCATGTCAACTATGGTCTGACATGTCTCTTCAGACACAAAGG

TCCGAAGAGGACAAAGATTCCTCTCTGCTTCTAGAATAATCAGATTATATCCC

GCAAATTTATCACTTGTTTACCTCTGGAGGAGAGAACATATGGGCTCAACTCC

AACCCTTGGGAGCAATATAACAAAAAACATGTTATGGTGCCATTAAACCGCT

GCATTTCATCAAAGTCAAGTTGATTACCTTTACATTTTGATCCTCTTGGATGTG

AAAAAAACT ATT AAC ATCCCTC AAAAGACcccggg AAAGAT GGTTCCTC AGGCT

CTCCTGTTTGTACCCCTTCTGGTTTTTCCATTGTGTTTTGGGAAATTCCCTATTT

AC AC GAT ACC AG AC A AGC TT GGT C CC T GGAGTCC GATT GAC AT AC AT C AC CT

CAGCTGCCCAAACAATTTGGTAGTGGAGGACGAAGGATGCACCAACCTGTCA

GGGTTCTCCTACATGGAACTTAAAGTTGGATACATCTTAGCCATAAAAGTGA

ACGGGTTCACTTGCACAGGCGTTGTGACGGAGGCTGAAACCTACACTAACTT

CGTTGGTTATGTCACAACCACGTTCAAAAGAAAGCATTTCCGCCCAACACCA

GATGCATGTAGAGCCGCGTACAACTGGAAGATGGCCGGTGACCCCAGATATG

AAGAGTCTCTACACAATCCGTACCCTGACTACCGCTGGCTTCGAACTGTAAAA

ACCACCAAGGAGTCTCTCGTTATCATATCTCCAAGTGTGGCAGATTTGGACCC

ATATGACAGATCCCTTCACTCGAGGGTCTTCCCTAGCGGGAAGTGCTCAGGA

GTAGCGGTGTCTTCTACCTACTGCTCCACTAACCACGATTACACCATTTGGAT

GCCCGAGAATCCGAGACTAGGGATGTCTTGTGACATTTTTACCAATAGTAGA

GGGAAGAGAGC ATCC AAAGGGAGT GAGACTT GCGGCTTTGT AGAT GAAAGA

GGCCTATATAAGTCTTTAAAAGGAGCATGCAAACTCAAGTTATGTGGAGTTCT

AGGACTT AGACTT AT GGATGGAAC AT GGGTCTCGAT GC AAAC ATC AAAT GAA

ACCAAATGGTGCCCTCCCGATAAGTTGGTGAACCTGCACGACTTTCGCTCAGA

CGAAATTGAGCACCTTGTTGTAGAGGAGTTGGTCAGGAAGAGAGAGGAGTGT

CTGGATGCACTAGAGTCCATCATGACAACCAAGTCAGTGAGTTTCAGACGTC

TCAGTCATTTAAGAAAACTTGTCCCTGGGTTTGGAAAAGCATATACCATATTC

AACAAGACCTTGATGGAAGCCGATGCTCACTACAAGTCAGTCgagACTTGGAA

TGAGATCCTCCCTTCAAAAGGGTGTTTAAGAGTTGGGGGGAGGTGTCATCCTC

ATGTGAACGGGGTGTTTTTCAATGGTATAATATTAGGACCTGACGGCAATGTC

TTAATCCCAGAGATGCAATCATCCCTCCTCCAGCAACATATGGAGTTGTTGGA

ATCCTCGGTTATCCCCCTTGTGCACCCCCTGGCAGACCCGTCTACCGTTTTCA

AGGACGGTGACGAGGCTGAGGATTTTGTTGAAGTTCACCTTCCCGATGTGCA

CAATCAGGTCTCAGGAGTTGACTTGGGTCTCCCGAACTGGGGGAAGTATGTA

TTACTGAGTGCAGGGGCCCTGACTGCCTTGATGTTGATAATTTTCCTGATGAC AT GTT GT AGAAGAGT C AATCGAT C AGAACCT ACGC AAC AC AATCTC AGAGGG

AC AGGGAGGGAGGT GT C AGTC ACTCCCC AAAGCGGGAAGATC AT ATCTTC AT

GGGAATCACACAAGAGTGGGGGTGAGACCAGACTGTAAttaattaaCGTCCTTTCA

AC GAT C C A AGTCcatgaaaaaaactaacacccctcccgtacctagcTT AT A A AGT GC T GGGT CAT

CT AAGCTTTT C AGTCGAGAAA AAAAC ATT AGATC AGAAGAAC AACTGGC AAC

ACTTCTCAACCTGAGACTTACTTCAAGATGCTCGATCCTGGAGAGGTCTATGA

TGACCCTATTGACCCAATCGAGTTAGAGGCTGAACCCAGAGGAACCCCCATT

GTCCCCAACATCTTGAGGAACTCTGACTACAATCTCAACTCTCCTTTGATAGA

AGATCCTGCTAGACTAATGTTAGAATGGTTAAAAACAGGGAATAGACCTTAT

CGGATGACTCTAACAGACAATTGCTCCAGGTCTTTCAGAGTTTTGAAAGATTA

TTTCAAGAAGGTAGATTTGGGTTCTCTCAAGGTGGGCGGAATGGCTGCACAG

TCAATGATTTCTCTCTGGTTATATGGTGCCCACTCTGAATCCAACAGGAGCCG

GAGATGTATAACAGACTTGGCCCATTTCTATTCCAAGTCGTCCCCCATAGAGA

AGCTGTTGAATCTCACGCTAGGAAATAGAGGGCTGAGAATCCCCCC AGAGGG

AGT GTT A AGTT GCC TT GAGAGGGTTG ATT AT GAT A AT GC ATTTGGA AGGT AT C

TTGCCAACACGTATTCCTCTTACTTGTTCTTCCATGTAATCACCTTATACATGA

ACGCCCTAGACTGGGATGAAGAAAAGACCATCCTAGCATTATGGAAAGATTT

A AC CTC AGT GGAC ATCGGGA AGGAC TT GGT A A AGTTC A A AGAC C A A AT AT GG

GGACTGCTGATCGTGACAAAGGACTTTGTTTACTCCCAAAGTTCCAATTGTCT

TTTTGACAGAAACTACACACTTATGCTAAAAGATCTTTTCTTGTCTCGCTTCA

ACTCCTTAATGGTCTTGCTCTCTCCCCCAGAGCCCCGATACTCAGATGACTTG

ATATCTCAACTATGCCAGCTGTACATTGCTGGGGATCAAGTCTTGTCTATGTG

TGGAAACTCCGGCTATGAAGTCATCAAAATATTGGAGCCATATGTCGTGAAT

AGTTTAGTCCAGAGAGCAGAAAAGTTTAGGCCTCTCATTCATTCCTTGGGAGA

CTTTCCTGTATTTATAAAAGACAAGGTAAGTCAACTTGAAGAGACGTTCGGTC

CCTGTGCAAGAAGGTTCTTTAGGGCTCTGGATCAATTCGACAACATACATGAC

TTGGTTTTTGTGTTTGGCTGTTACAGGCATTGGGGGCACCCATATATAGATTA

TCGAAAGGGTCTGTCAAAACTATATGATCAGGTTCACCTTAAAAAAATGATA

GATAAGTCCTACCAGGAGTGCTTAGCAAGCGACCTAGCCAGGAGGATCCTTA

GAT GGGGTTTT GAT AAGT ACTCC AAGT GGT ATCTGGATT C A AGATTCCT AGCC

CGAGACCACCCCTTGACTCCTTATATCAAAACCCAAACATGGCCACCCAAAC

AT ATT GT AGACTTGGT GGGGGAT AC ATGGC AC AAGCTCCCGAT C ACGC AG AT

CTTTGAGATTCCTGAATCAATGGATCCGTCAGAAATATTGGATGACAAATCAC

ATTCTTTCACCAGAACGAGACTAGCTTCTTGGCTGTCAGAAAACCGAGGGGG GCCTGTTCCTAGCGAAAAAGTTATTATCACGGCCCTGTCTAAGCCGCCTGTCA

ATCCCCGAGAGTTTCTGAGGTCT AT AGACCTCGGAGGATT GCC AGATGAAGA

CTTGATAATTGGCCTCAAGCCAAAGGAACGGGAATTGAAGATTGAAGGTCGA

TTCTTTGCTCTAATGTCATGGAATCTAAGATTGTATTTTGTCATCACTGAAAAA

CTCTTGGCCAACTACATCTTGCCACTTTTTGACGCGCTGACTATGACAGACAA

CCTGAACAAGGTGTTTAAAAAGCTGATCGACAGGGTCACCGGGCAAGGGCTT

TTGGACTATTCAAGGGTCACATATGCATTTCACCTGGACTATGAAAAGTGGA

ACAACCATCAAAGATTAGAGTCAACAGAGGATGTATTTTCTGTCCTAGATCA

AGT GTTTGGATT GAAGAGAGT GTTTTCT AGAAC AC ACGAGTTTTTT C AAAAGG

CCTGGATCTATTATTCAGACAGATCAGACCTCATCGGGTTACGGGAGGATCA

AATATACTGCTTAGATGCGTCCAACGGCCCAACCTGTTGGAATGGCCAGGAT

GGCGGGCTAGAAGGCTTACGGCAGAAGGGCTGGAGTCTAGTCAGCTTATTGA

T GAT AGAT AGAGAATCTC AA ATC AGGAAC AC AAGAACC AAAAT ACT AGCTC A

AGGAGACAACCAGGTTTTATGTCCGACATACATGTTGTCGCCAGGGCTATCTC

AAGAGGGGCTCCTCTATGAATTGGAGAGAATATCAAGGAATGCACTTTCGAT

AT AC AG AGC C GT C G AGG A AGGGGC AT C T A AGC T AGGGC T GAT CATC A AG A A

AGAAGAGACCATGTGTAGTTATGACTTCCTCATCTATGGAAAAACCCCTTTGT

TT AGAGGT AAC AT ATT GGT GCCTGAGTCC AAAAGAT GGGCC AGAGTCTCTTG

CGTCTCTAATGACCAAATAGTCAACCTCGCCAATATAATGTCGACAGTGTCCA

CCAATGCGCTAACAGTGGCACAACACTCTCAATCTTTGATCAAACCGATGAG

GGATTTTCTGCTCATGTCAGTACAGGCAGTCTTTCACTACCTGCTATTTAGCCC

AATCTT AAAGGGA AGAGTTT AC AAGATTCTGAGCGCTGAAGGGGAGAGCTTT

CTCCTAGCCATGTCAAGGATAATCTATCTAGATCCTTCTTTGGGAGGGATATC

TGGAATGTCCCTCGGAAGATTCCATATACGACAGTTCTCAGACCCTGTCTCTG

AAGGGTTATCCTTCTGGAGAGAGATCTGGTTAAGCTCCCAAGAGTCCTGGATT

C ACGCGTTGT GT C AAGAGGCTGGAAACCC AGATCTTGGAGAGAGAAC ACTCG

AGAGCTTCACTCGCCTTCTAGAAGATCCGACCACCTTAAATATCAGAGGAGG

GGCCAGTCCTACCATTCTACTCAAGGATGCAATCAGAAAGGCTTTATATGAC

GAGGT GGAC AAGGTGGA AAATT C AGAGTTTCGAGAGGC AATCCTGTT GTCC A

AGACCCATAGAGATAATTTTATACTCTTCTTAATATCTGTTGAGCCTCTGTTTC

CTCGATTTCTCAGTGAGCTATTCAGTTCGTCTTTTTTGGGAATCCCCGAGTCAA

TCATTGGATTGATACAAAACTCCCGAACGATAAGAAGGCAGTTTAGAAAGAG

TCTCTCAAAAACTTTAGAAGAATCCTTCTACAACTCAGAGATCCACGGGATTA

GTCGGATGACCCAGACACCTCAGAGGGTTGGGGGGGTGTGGCCTTGCTCTTC AGAGAGGGC AGATCT ACTT AGGGAGATCTCTT GGGGAAGAAAAGT GGT AGG

CACGACAGTTCCTCACCCTTCTGAGATGTTGGGATTACTTCCCAAGTCCTCTA

TTTCTTGCACTTGTGGAGCAACAGGAGGAGGCAATCCTAGAGTTTCTGTATCA

GTACTCCCGTCCTTTGATCAGTCATTTTTTTCACGAGGCCCCCTAAAGGGATA

CTTGGGCTCGTCCACCTCTATGTCGACCCAGCTATTCCATGCATGGGAAAAAG

T C ACT A AT GTT CAT GT GGT GA AGAGAGCTCT AT C GTT A A A AGA ATCT AT A A AC

TGGTTCATTACTAGAGATTCCAACTTGGCTCAAGCTCTAATTAGGAACATTAT

GTCTCTGACAGGCCCTGATTTCCCTCTAGAGGAGGCCCCTGTCTTCAAAAGGA

CGGGGTCAGCCTTGCATAGGTTCAAGTCTGCCAGATACAGCGAAGGAGGGTA

TTCTTCTGTCTGCCCGAACCTCCTCTCTCATATTTCTGTTAGTACAGACACCAT

GTCTGATTTGACCCAAGACGGGAAGAACTACGATTTCATGTTCCAGCCATTGA

TGCTTTATGCACAGACATGGACATCAGAGCTGGTACAGAGAGACACAAGGCT

AAGAGACTCTACGTTTCATTGGCACCTCCGATGCAACAGGTGTGTGAGACCC

ATTGACGACGTGACCCTGGAGACCTCTCAGATCTTCGAGTTTCCGGATGTGTC

GAAAAGAATATCCAGAATGGTTTCTGGGGCTGTGCCTCACTTCCAGAGGCTTC

CCGATATCCGTCTGAGACCAGGAGATTTTGAATCTCTAAGCGGTAGAGAAAA

GTCTCACCATATCGGATCAGCTCAGGGGCTCTTATACTCAATCTTAGTGGCAA

TTCACGACTCAGGATACAATGATGGAACCATCTTCCCTGTCAACATATACGGC

AAGGTTTCCCCT AGAGACT ATTT GAGAGGGCTCGC AAGGGGAGT ATT GAT AG

GATCCTCGATTTGCTTCTTGACAAGAATGACAAATATCAATATTAATAGACCT

CTTGAATTGGTCTCAGGGGTAATCTCATATATTCTCCTGAGGCTAGATAACCA

TCCCTCCTTGTACATAATGCTCAGAGAACCGTCTCTTAGAGGAGAGATATTTT

CTATCCCTCAGAAAATCCCCGCCGCTTATCCAACCACTATGAAAGAAGGCAA

CAGATCAATCTTGTGTTATCTCCAACATGTGCTACGCTATGAGCGAGAGATAA

TCACGGCGTCTCCAGAGAATGACTGGCTATGGATCTTTTCAGACTTTAGAAGT

GCCAAAATGACGTACCTATCCCTCATTACTTACCAGTCTCATCTTCTACTCCA

GAGGGTTGAGAGAAACCTATCTAAGAGTATGAGAGATAACCTGCGACAATTG

AGTTCTTTGATGAGGCAGGTGCTGGGCGGGCACGGAGAAGATACCTTAGAGT

CAGACGACAACATTCAACGACTGCTAAAAGACTCTTTACGAAGGACAAGATG

GGT GGATC AAGAGGT GCGCC ATGC AGCT AGAACC AT GACTGGAGATT AC AGC

CCCAACAAGAAGGTGTCCCGTAAGGTAGGATGTTCAGAATGGGTCTGCTCTG

CTCAACAGGTTGCAGTCTCTACCTCAGCAAACCCGGCCCCTGTCTCGGAGCTT

GACATAAGGGCCCTCTCTAAGAGGTTCCAGAACCCTTTGATCTCGGGCTTGAG

AGTGGTTCAGTGGGCAACCGGTGCTCATTATAAGCTTAAGCCTATTCTAGATG ATCTCAATGTTTTCCCATCTCTCTGCCTTGTAGTTGGGGACGGGTCAGGGGGG

ATATCAAGGGCAGTCCTCAACATGTTTCCAGATGCCAAGCTTGTGTTCAACAG

TCTTTTAGAGGTGAATGACCTGATGGCTTCCGGAACACATCCACTGCCTCCTT

CAGCAATCATGAGGGGAGGAAATGATATCGTCTCCAGAGTGATAGATCTTGA

CTCAATCTGGGAAAAACCGTCCGACTTGAGAAACTTGGCAACCTGGAAATAC

TTCCAGTCAGTCCAAAAGCAGGTCAACATGTCCTATGACCTCATTATTTGCGA

TGCAGAAGTTACTGACATTGCATCTATCAACCGGATCACCCTGTTAATGTCCG

ATTTTGCATTGTCTATAGATGGACCACTCTATTTGGTCTTCAAAACTTATGGG

ACTATGCTAGTAAATCCAAACTACAAGGCTATTCAACACCTGTCAAGAGCGT

TCCCCTCGGTCACAGGGTTTATCACCCAAGTAACTTCGTCTTTTTCATCTGAGC

TCTACCTCCGATTCTCCAAACGAGGGAAGTTTTTCAGAGATGCTGAGTACTTG

ACCTCTTCCACCCTTCGAGAAATGAGCCTTGTGTTATTCAATTGTAGCAGCCC

CAAGAGTGAGATGCAGAGAGCTCGTTCCTTGAACTATCAGGATCTTGTGAGA

GGATTTCCTGAAGAAATCATATCAAATCCTTACAATGAGATGATCATAACTCT

GATTGAC AGT GATGT AGAATCTTTTCT AGTCC AC AAGAT GGTT GAT GATCTT G

AGTTACAGAGGGGAACTCTGTCTAAAGTGGCTATCATTATAGCCATCATGAT

AGTTTTCTCCAACAGAGTCTTCAACGTTTCCAAACCCCTAACTGACCCCTCGT

TCTATCCACCGTCTGATCCCAAAATCCTGAGGCACTTCAACATATGTTGCAGT

ACTATGATGTATCTATCTACTGCTTTAGGTGACGTCCCTAGCTTCGCAAGACT

TCACGACCTGTATAACAGACCTATAACTTATTACTTCAGAAAGCAAGTCATTC

GAGGGA AC GTTT AT C T ATCTTGGAGTT GGT C C A AC GAC AC CTC AGT GTT C A A A

AGGGTAGCCTGTAATTCTAGCCTGAGTCTGTCATCTCACTGGATCAGGTTGAT

TTAC AAGAT AGTGAAGACTACCAGACTCGTTGGCAGCATCAAGGATCTATCC

AGAGAAGTGGAAAGACACCTTCATAGGTACAACAGGTGGATCACCCTAGAG

GATATCAGATCTAGATCATCCCTACTAGACTACAGTTGCCTGTGAACCGGATA

CTCCTGGAAGCCTGCCCATGCTAAGACTCTTGTGTGATGTATCTTGAAAAAAA

CAAGATCCTAAATCTGAACCTTTGGTTGTTTGATTGTTTTTCTCAtttttgttgtttatttgtt aagcgt.

In other embodiments, the nucleic acid comprises the sequence of SEQ ID NO: 9, shown below (RABV vector: Coravax V2 South Africa (S1-RABVG-E51)): ACGCTTAACAACCAGATCAAAGAAAAAACAGACATTGTCAATTGCAAAGCAA AAATGTAACACCCCTACAATGGATGCCGACAAGATTGTATTCAAAGTCAATA AT C AGGT GGT C TC TT T G A AGC C T GAG AT T AT C GT GG AT C A AT AT G AGT AC A AG TACCCTGCCATCAAAGATTTGAAAAAGCCCTGTATAACCCTAGGAAAGGCTC CCGATTTAAATAAAGCATACAAGTCAGTTTTGTCAGGCATGAGCGCCGCCAA

ACTTAATCCTGACGATGTATGTTCCTATTTGGCAGCGGCAATGCAGTTTTTTG

AGGGGACATGTCCGGAAGACTGGACCAGCTATGGAATTGTGATTGCACGAAA

AGGAGATAAGATCACCCCAGGTTCTCTGGTGGAGATAAAACGTACTGATGTA

GAAGGGAATT GGGCTCTGAC AGGAGGC AT GGAACTGAC AAGAGACCCC ACT

GTCCCTGAGCATGCGTCCTTAGTCGGTCTTCTCTTGAGTCTGTATAGGTTGAG

CAAAATATCCGGGCAAAACACTGGTAACTATAAGACAAACATTGCAGACAGG

ATAGAGCAGATTTTTGAGACAGCCCCTTTTGTTAAAATCGTGGAACACCATAC

TC T A AT GAC A AC TC AC A Aa AT GT GT GCT A ATT GGAGT ACT AT AC C A A AC TTC A

GATTTTTGGCCGGAACCTATGACATGTTTTTCTCCCGGATTGAGCATCTATATT

CAGCAATCAGAGTGGGCACAGTTGTCACTGCTTATGAAGACTGTTCAGGACT

GGTATCATTTACTGGGTTCATAAAACAAATCAATCTCACCGCTAGAGAGGCA

ATACTATATTTCTTCCACAAGAACTTTGAGGAAGAGATAAGAAGAATGTTTG

AGCCAGGGCAGGAGACAGCTGTTCCTCACTCTTATTTCATCCACTTCCGTTCA

CTAGGCTTGAGTGGGAAATCTCCTTATTCATCAAATGCTGTTGGTCACGTGTT

CAATCTCATTCACTTTGTAGGATGCTATATGGGTCAAGTCAGATCCCTAAATG

CAACGGTTATTGCTGCATGTGCTCCTCATGAAATGTCTGTTCTAGGGGGCTAT

CTGGGAGAGGAATTCTTCGGGAAAGGGAC ATTTGAAAGAAGATTCTTC AGAG

AT GAG A A AG A AC TT C A AG A AT AC G AGGC GGC T G A AC T GAC A A AG AC T GAC G

TAGCACTGGCAGATGATGGAACTGTCAACTCTGACGACGAGGACTACTTTTC

AGGT GAAACC AGAAGTCCGGAGGCTGTTT AT ACTCGAAT CAT GAT GAAT GGA

GGTCGACTAAAGAGATCTCACATACGGAGATATGTCTCAGTCAGTTCCAATC

ATCAAGCCCGTCCAAACTCATTCGCCGAGTTTCTAAACAAGACATATTCGAGT

GACTCATAAcatgaaaaaaactaacacccctcccgtacgCCACCATGTTCGTGTTTCTGGTGCT

GCTGCCTCTGGTGAGCTCCCAGTGCGTGAACTTCACCACAAGGACCCAGCTG

CCCCCTGCCTATACCAATTCCTTCACACGGGGCGTGTACTATCCCGACAAGGT

GTTCCGGAGCAGCGTGCTGCACTCCACACAGGATCTGTTTCTGCCTTTCTTTTC

TAACGTGACCTGGTTCCACGCCATCCACGTGAGCGGCACCAATGGCACAAAG

CGGTTCGCCAATCCAGTGCTGCCCTTTAACGATGGCGTGTACTTCGCCTCCAC

CGAGAAGTCTAACATCATCAGAGGCTGGATCTTTGGCACCACACTGGACAGC

AAGACACAGTCCCTGCTGATCGTGAACAATGCCACCAACGTGGTCATCAAGG

TGTGCGAGTTCCAGTTTTGTAATGATCCATTCCTGGGCGTGTACTATCACAAG

AACAATAAGTCTTGGATGGAGAGCGAGTTTCGCGTGTATTCCTCTGCCAACA

ATTGCACATTTGAGTACGTGTCCCAGCCCTTCCTGATGGACCTGGAGGGCAAG C AGGGC AATTT C AAGAACCTGAGGGAGTTCGT GTTT AAGAAT ATCGATGGCT

ACTTCAAAATCTACTCCAAGCACACCCCAATCAACCTGGTGCGCGGCCTGCC

ACAGGGCTTCTCTGCCCTGGAGCCACTGGTGGATCTGCCCATCGGCATCAACA

TCACCCGGTTTCAGACACTGCTGGCCCTGCACAGAAGCTACCTGACACCAGG

CGACAGCTCCTCTGGATGGACCGCAGGAGCAGCAGCCTACTATGTGGGCTAT

CTGCAGCCCAGGACCTTCCTGCTGAAGTACAACGAGAATGGCACCATCACAG

ACGCCGTGGATTGCGCCCTGGATCCCCTGTCTGAGACCAAGTGTACACTGAA

GAGCTTTACCGTGGAGAAGGGCATCTATCAGACAAGCAATTTCAGGGTGCAG

CCTACCGAGTCCATCGTGCGCTTTCCCAATATCACAAACCTGTGCCCTTTTGG

CGAGGTGTTCAACGCAACCCGCTTCGCCAGCGTGTACGCCTGGAATAGGAAG

CGCATCTCCAACTGCGTGGCCGACTATTCTGTGCTGTACAACAGCGCCTCCTT

CTCTACCTTTAAGTGCTATGGCGTGAGCCCCACAAAGCTGAATGACCTGTGCT

TTACCAACGTGTACGCCGATTCCTTCGTGATCAGGGGCGACGAGGTGCGCCA

GATCGC ACC AGGAC AGAC AGGC AAT ATCGC AGACT AC AATT AT AAGCTGCCT

GACGATTTCACCGGCTGCGTGATCGCCTGGAACTCTAACAATCTGGATAGCA

AAGTGGGCGGCAACTACAATTATCTGTACCGGCTGTTTAGAAAGTCTAATCTG

AAGCCATTCGAGAGGGACATCTCCACAGAAATCTACCAGGCCGGCTCTACCC

CCTGCAATGGCGTGAAGGGCTTTAACTGTTATTTCCCTCTGCAGAGCTACGGC

TTCCAGCCAACATATGGCGTGGGCTATCAGCCCTACCGCGTGGTGGTGCTGTC

TTTTGAGCTGCTGCACGCACCTGCAACAGTGTGCGGACCAAAGAAGAGCACC

A ATCTGGT GA AGA AC A AGT GCGT GA AC TT C A AC TT C A AC GGACTGACC GGA A

CAGGCGTGCTGACCGAGTCCAACAAGAAGTTCCTGCCTTTTCAGCAGTTCGGC

AGGGACATCGCAGATACCACAGACGCCGTGCGCGACCCTCAGACCCTGGAGA

TCCTGGACATCACACCATGCTCCTTCGGCGGCGTGTCTGTGATCAC ACC AGGC

ACCAATACAAGCAACCAGGTGGCCGTGCTGTATCAGGGCGTGAATTGTACCG

AGGTGCCAGTGGCAATCCACGCAGATCAGCTGACCCCTACATGGCGGGTGTA

CTCTACCGGCAGCAACGTGTTCCAGACAAGAGCCGGATGCCTGATCGGAGCA

GAGCACGTGAACAATAGCTATGAGTGCGACATCCCTATCGGCGCCGGCATCT

GTGCCTCCTACCAGACCCAGACAAACTCCCCAGAATCAAGCGTGATTCCTCTG

GTCCATCCACTGGCAGATCCCTCCACAGTGTTCAAAGACGGAGATGAGGCCG

AAGACTTTGTGGAAGTCCACCTGCCTGATGTGCATAACCAGGTGTCTGGCGTC

GACCTGGGACTGCC AAATT GGGGC AAGT ACGT GCTGCTGAGT GCTGGAGC AC

TGACTGCCCTGATGCTGATCATTTTCCTGATGACCTGCTGTCGGCGCGTGAAC

AG A AGT G AGC C C AC TC AGC AC AAT C T GC G AGG A AC C GGG AG AG A AGT GT C A GT C AC AC CTC AGAGC GGGA A A AT C ATT AGT AGTT GGGA AT C AC AT A A A AGCG

GGGGCGAGACC AGGCTGT GAgctagcC AT GAAAAAAACT AAC ACCCCTCCTTT C

GAACCATCCCAAACATGAGCAAGATCTTTGTCAATCCTAGTGCTATTAGAGCC

GGTCTGGCCGATCTTGAGAT GGCTGAAGAAACTGTT GATCTGATC AAT AGAA

AT AT C GA AG AC A AT C AGGC TC AT C TCC A AGGGGA ACC C AT AGAGGT GGAC A A

TCTCCCTGAGGATATGGGGCGACTTCACCTGGATGATGGAAAATCGCCCAAC

CATGGTGAGATAGCCAAGGTGGGAGAAGGCAAGTATCGAGAGGACTTTCAG

ATGGATGAAGGAGAGGATCCTAGCTTCCTGTTCCAGTCATACCTGGAAAATG

TTGGAGTCC AAAT AGTC AGAC AAAT GAGGT C AGGAGAGAGATTTCTC AAGAT

ATGGTCACAGACCGTAGAAGAGATTATATCCTATGTCGCGGTCAACTTTCCCA

ACCCTCCAGGAAAGTCTTCAGAGGATAAATCAACCCAGACTACTGGCCGAGA

GCTCAAGAAGGAGACAACACCCACTCCTTCTCAGAGAGAAAGCCAATCATCG

AAAGCCAGGATGGCGGCTCAAATTGCTTCTGGCCCTCCAGCCCTTGAATGGTC

GGCT ACC AAT GAAGAGGAT GATCT ATC AGT GGAGGCTGAGATCGCTC ACC AG

ATTGCAGAAAGTTTCTCCAAAAAATATAAGTTTCCCTCTCGATCCTCAGGGAT

ACTCTTGTATAATTTTGAGCAATTGAAAATGAACCTTGATGATATAGTTAAAG

AGGC A AAAAAT GT ACC AGGT GT GACCCGTTT AGCCC AT GACGGGTCC AAACT

CCCCCTAAGATGTGTACTGGGATGGGTCGCTTTGGCCAACTCTAAGAAATTCC

AGTTGTT AGTCGAATCCGAC AAGCTGAGT AAAAT CAT GC AAGAT GACTTGAA

TCGCTATACATCTTGCTAACCGAACCTCTCCCCTCAGTCCCTCTAGACAATAA

AATCCGAGATGTCCCAAAGTCAACATGAAAAAAAC AGGC AAC ACC ACTGATA

AAATGAACCTCCTACGTAAGATAGTGAAAAACCGCAGGGACGAGGACACTC

AAAAATCCTCTCCCGCGTCAGCCCCTCTGGATGACGATGACTTGTGGCTTCCA

CCCCCTGAATACGTCCCGCTGAAAGAACTTACAGGCAAGAAGAACATGAGGA

ACTTTTGTATCAACGGAAGGGTTAAAGTGTGTAGCCCGAATGGTTACTCGTTC

AGGATCCTGCGGCACATTCTGAAATCATTCGACGAGATATATTCTGGGAATC

ATAGGATGATCGGGTTAGTCAAAGTGGTTATTGGACTGGCTTTGTCAGGATCT

CCAGTCCCTGAGGGCCTGAACTGGGTATACAAATTGAGGAGAACCTTTATCTT

CCAGTGGGCTGATTCCAGGGGCCCTCTTGAAGGGGAGGAGTTGGAATACTCT

CAGGAGATCACTTGGGATGATGATACTGAGTTCGTCGGATTGCAAATAAGAG

T GATT GCA A A AC AGT GTC AT ATCC AGGGC AGAGTCTGGT GT AT C A AC AT GA A

CCCGAGAGCATGTCAACTATGGTCTGACATGTCTCTTCAGACACAAAGGTCC

GAAGAGGACAAAGATTCCTCTCTGCTTCTAGAATAATCAGATTATATCCCGCA

AATTTATCACTTGTTTACCTCTGGAGGAGAGAACATATGGGCTCAACTCCAAC CCTT GGGAGC AAT AT AAC AAAAAAC AT GTT ATGGT GCC ATT AAACCGCTGC A

TTTCATCAAAGTCAAGTTGATTACCTTTACATTTTGATCCTCTTGGATGTGAAA

AAAACTATTAACATCCCTCAAAAGACcccgggAAAGATGGTTCCTCAGGCTCTC

CTGTTTGTACCCCTTCTGGTTTTTCCATTGTGTTTTGGGAAATTCCCTATTTAC

ACGATACCAGACAAGCTTGGTCCCTGGAGTCCGATTGACATACATCACCTCA

GCTGCCCAAACAATTTGGTAGTGGAGGACGAAGGATGCACCAACCTGTCAGG

GTTCTCCTACATGGAACTTAAAGTTGGATACATCTTAGCCATAAAAGTGAACG

GGTTCACTTGCACAGGCGTTGTGACGGAGGCTGAAACCTACACTAACTTCGTT

GGTTATGTCACAACCACGTTCAAAAGAAAGCATTTCCGCCCAACACCAGATG

CATGTAGAGCCGCGTACAACTGGAAGATGGCCGGTGACCCCAGATATGAAGA

GTCTCTACACAATCCGTACCCTGACTACCGCTGGCTTCGAACTGTAAAAACCA

CCAAGGAGTCTCTCGTTATCATATCTCCAAGTGTGGCAGATTTGGACCCATAT

GACAGATCCCTTCACTCGAGGGTCTTCCCTAGCGGGAAGTGCTCAGGAGTAG

CGGTGTCTTCTACCTACTGCTCCACTAACCACGATTACACCATTTGGATGCCC

GAGAATCCGAGACT AGGGAT GTCTT GT GAC ATTTTT ACC AAT AGT AGAGGGA

AGAGAGC ATCC AAAGGGAGT GAGACTTGCGGCTTT GT AG AT GAAAGAGGCCT

ATATAAGTCTTTAAAAGGAGCATGCAAACTCAAGTTATGTGGAGTTCTAGGA

CTTAGACTTATGGATGGAACATGGGTCTCGATGCAAACATCAAATGAAACCA

AATGGTGCCCTCCCGATAAGTTGGTGAACCTGCACGACTTTCGCTCAGACGA

A ATTGAGC ACC TT GTT GT AGAGGAGTT GGT C AGGA AGAGAGAGGAGT GTCTG

GATGCACTAGAGTCCATCATGACAACCAAGTCAGTGAGTTTCAGACGTCTCA

GTCATTTAAGAAAACTTGTCCCTGGGTTTGGAAAAGCATATACCATATTCAAC

AAGACCTTGAT GGAAGCCGAT GCTC ACT AC AAGT C AGT Cgag ACTT GGAAT GA

GATCCTCCCTTCAAAAGGGTGTTTAAGAGTTGGGGGGAGGTGTCATCCTCATG

TGAACGGGGTGTTTTTCAATGGTATAATATTAGGACCTGACGGCAATGTCTTA

ATCCCAGAGATGCAATCATCCCTCCTCCAGCAACATATGGAGTTGTTGGAATC

CTCGGTTATCCCCCTTGTGCACCCCCTGGCAGACCCGTCTACCGTTTTCAAGG

ACGGTGACGAGGCTGAGGATTTTGTTGAAGTTCACCTTCCCGATGTGCACAAT

CAGGTCTCAGGAGTTGACTTGGGTCTCCCGAACTGGGGGAAGTATGTATTACT

GAGTGCAGGGGCCCTGACTGCCTTGATGTTGATAATTTTCCTGATGACATGTT

GT AGAAGAGTC AATCGAT C AGAACCT ACGC AAC AC AATCTC AGAGGGAC AG

GGAGGGAGGTGTCAGTCACTCCCCAAAGCGGGAAGATCATATCTTCATGGGA

ATCACACAAGAGTGGGGGTGAGACCAGACTGTAAttaattaaCGTCCTTTCAACGA

TCC A AGTCcatgaaaaaaactaacacccctcccgtacctagcTT AT A A AGT GC T GGGT C ATCT A AG CTTTTCAGTCGAGAAAAAAACATTAGATCAGAAGAACAACTGGCAACACTTC

TCAACCTGAGACTTACTTCAAGATGCTCGATCCTGGAGAGGTCTATGATGACC

CTATTGACCCAATCGAGTTAGAGGCTGAACCCAGAGGAACCCCCATTGTCCC

CAACATCTTGAGGAACTCTGACTACAATCTCAACTCTCCTTTGATAGAAGATC

CTGCT AGACT AATGTT AGAATGGTT AAAAAC AGGGAAT AGACCTT ATCGGAT

GACTCTAACAGACAATTGCTCCAGGTCTTTCAGAGTTTTGAAAGATTATTTCA

AGAAGGTAGATTTGGGTTCTCTCAAGGTGGGCGGAATGGCTGCACAGTCAAT

GATTTCTCTCTGGTTATATGGTGCCCACTCTGAATCCAACAGGAGCCGGAGAT

GTATAACAGACTTGGCCCATTTCTATTCCAAGTCGTCCCCCATAGAGAAGCTG

TTGAATCTCACGCTAGGAAATAGAGGGCTGAGAATCCCCCCAGAGGGAGTGT

T A AGTT GCC TT GAGAGGGTTGATT AT GAT A AT GC ATTT GGA AGGT AT C TT GCC

AACACGTATTCCTCTTACTTGTTCTTCCATGTAATCACCTTATACATGAACGCC

CTAGACTGGGATGAAGAAAAGACCATCCTAGCATTATGGAAAGATTTAACCT

C AGT GG AC ATC GGG A AGG AC TT GGT A A AGT T C A A AG AC C A A AT AT GGGG AC T

GCTGATCGTGACAAAGGACTTTGTTTACTCCCAAAGTTCCAATTGTCTTTTTG

ACAGAAACTACACACTTATGCTAAAAGATCTTTTCTTGTCTCGCTTCAACTCC

TTAATGGTCTTGCTCTCTCCCCCAGAGCCCCGATACTCAGATGACTTGATATC

TCAACTATGCCAGCTGTACATTGCTGGGGATCAAGTCTTGTCTATGTGTGGAA

ACTCCGGCTATGAAGTCATCAAAATATTGGAGCCATATGTCGTGAATAGTTTA

GTCCAGAGAGCAGAAAAGTTTAGGCCTCTCATTCATTCCTTGGGAGACTTTCC

TGTATTTATAAAAGACAAGGTAAGTCAACTTGAAGAGACGTTCGGTCCCTGT

GCAAGAAGGTTCTTTAGGGCTCTGGATCAATTCGACAACATACATGACTTGGT

TTTTGTGTTTGGCTGTTACAGGCATTGGGGGCACCCATATATAGATTATCGAA

AGGGTCTGTC AAAACT AT ATGAT C AGGTTC ACCTT AAAAAAATGAT AG AT AA

GTCCTACCAGGAGTGCTTAGCAAGCGACCTAGCCAGGAGGATCCTTAGATGG

GGTTTTGATAAGTACTCCAAGTGGTATCTGGATTCAAGATTCCTAGCCCGAGA

CCACCCCTTGACTCCTTATATCAAAACCCAAACATGGCCACCCAAACATATTG

T AGACTT GGT GGGGGAT AC AT GGC AC AAGCTCCCGAT C ACGC AGATCTTTGA

GATTCCTGAATCAATGGATCCGTCAGAAATATTGGATGACAAATCACATTCTT

TCACCAGAACGAGACTAGCTTCTTGGCTGTCAGAAAACCGAGGGGGGCCTGT

TCCTAGCGAAAAAGTTATTATCACGGCCCTGTCTAAGCCGCCTGTCAATCCCC

GAGAGTTTCTGAGGTCT AT AGACCTCGGAGGATT GCC AG AT GAAGACTTGAT

AATTGGCCTCAAGCCAAAGGAACGGGAATTGAAGATTGAAGGTCGATTCTTT

GCTCTAATGTCATGGAATCTAAGATTGTATTTTGTCATCACTGAAAAACTCTT GGCCAACTACATCTTGCCACTTTTTGACGCGCTGACTATGACAGACAACCTGA

ACAAGGTGTTTAAAAAGCTGATCGACAGGGTCACCGGGCAAGGGCTTTTGGA

CTATTCAAGGGTCACATATGCATTTCACCTGGACTATGAAAAGTGGAACAAC

CAT C AAAGATT AGAGTC AAC AGAGGAT GT ATTTTCTGTCCT AGATC AAGT GTT

T GGATT GAAGAGAGT GTTTTCT AGAAC AC ACGAGTTTTTTC AAAAGGCCTGGA

TCTATTATTCAGACAGATCAGACCTCATCGGGTTACGGGAGGATCAAATATA

CTGCTTAGATGCGTCCAACGGCCCAACCTGTTGGAATGGCCAGGATGGCGGG

CT AGAAGGCTT ACGGC AGAAGGGCTGGAGTCT AGT C AGCTT ATT GAT GAT AG

AT AGAGAATCTC AAAT C AGGAAC AC A AGAACC AAAAT ACT AGCTC AAGGAG

ACAACCAGGTTTTATGTCCGACATACATGTTGTCGCCAGGGCTATCTCAAGAG

GGGCTCCTCTATGAATTGGAGAGAATATCAAGGAATGCACTTTCGATATACA

GAGCCGTCGAGGAAGGGGCATCTAAGCTAGGGCTGATCATCAAGAAAGAAG

AGACCATGTGTAGTTATGACTTCCTCATCTATGGAAAAACCCCTTTGTTTAGA

GGTAACATATTGGTGCCTGAGTCCAAAAGATGGGCCAGAGTCTCTTGCGTCTC

T A AT GAC C A A AT AGT C A ACC T C GCC A AT AT A AT GTCG AC AGT GT C C AC C A AT

GCGCTAACAGTGGCACAACACTCTCAATCTTTGATCAAACCGATGAGGGATT

TTCTGCTCATGTCAGTACAGGCAGTCTTTCACTACCTGCTATTTAGCCCAATCT

T AAAGGGAAGAGTTT AC AAGATTCTGAGCGCTGAAGGGGAGAGCTTTCTCCT

AGCCATGTCAAGGATAATCTATCTAGATCCTTCTTTGGGAGGGATATCTGGAA

TGTCCCTCGGAAGATTCCATATACGACAGTTCTCAGACCCTGTCTCTGAAGGG

TTATCCTTCTGGAGAGAGATCTGGTTAAGCTCCCAAGAGTCCTGGATTCACGC

GTTGTGTCAAGAGGCTGGAAACCCAGATCTTGGAGAGAGAACACTCGAGAGC

TTCACTCGCCTTCTAGAAGATCCGACCACCTTAAATATCAGAGGAGGGGCCA

GTCCTACCATTCTACTCAAGGATGCAATCAGAAAGGCTTTATATGACGAGGT

GGAC AAGGT GGAAAATTC AGAGTTTCGAGAGGC AATCCTGTTGTCC A AGACC

CATAGAGATAATTTTATACTCTTCTTAATATCTGTTGAGCCTCTGTTTCCTCGA

TTTCTCAGTGAGCTATTCAGTTCGTCTTTTTTGGGAATCCCCGAGTCAATCATT

GGATTGATACAAAACTCCCGAACGATAAGAAGGCAGTTTAGAAAGAGTCTCT

CAAAAACTTTAGAAGAATCCTTCTACAACTCAGAGATCCACGGGATTAGTCG

GATGACCCAGACACCTCAGAGGGTTGGGGGGGTGTGGCCTTGCTCTTCAGAG

AGGGCAGATCTACTTAGGGAGATCTCTTGGGGAAGAAAAGTGGTAGGCACGA

CAGTTCCTCACCCTTCTGAGATGTTGGGATTACTTCCCAAGTCCTCTATTTCTT

GCACTTGTGGAGCAACAGGAGGAGGCAATCCTAGAGTTTCTGTATCAGTACT

CCCGTCCTTTGATCAGTCATTTTTTTCACGAGGCCCCCTAAAGGGATACTTGG GCTCGTCCACCTCTATGTCGACCCAGCTATTCCATGCATGGGAAAAAGTCACT

A AT GTT CAT GT GGT GA AGAGAGCTCT AT C GTT A A A AGA ATCT AT A A AC T GGTT

CATTACTAGAGATTCCAACTTGGCTCAAGCTCTAATTAGGAACATTATGTCTC

TGACAGGCCCTGATTTCCCTCTAGAGGAGGCCCCTGTCTTCAAAAGGACGGG

GTCAGCCTTGCATAGGTTCAAGTCTGCCAGATACAGCGAAGGAGGGTATTCT

TCTGTCTGCCCGAACCTCCTCTCTCATATTTCTGTTAGTACAGACACCATGTCT

GATTTGACCCAAGACGGGAAGAACTACGATTTCATGTTCCAGCCATTGATGCT

TT AT GC AC AG AC AT GGAC ATC AGAGCTGGT AC AGAGAGAC AC AAGGCT AAG

AGACTCTACGTTTCATTGGCACCTCCGATGCAACAGGTGTGTGAGACCCATTG

ACGACGTGACCCTGGAGACCTCTCAGATCTTCGAGTTTCCGGATGTGTCGAAA

AGAATATCCAGAATGGTTTCTGGGGCTGTGCCTCACTTCCAGAGGCTTCCCGA

TATCCGTCTGAGACCAGGAGATTTTGAATCTCTAAGCGGTAGAGAAAAGTCT

CACCATATCGGATCAGCTCAGGGGCTCTTATACTCAATCTTAGTGGCAATTCA

CGACTCAGGATACAATGATGGAACCATCTTCCCTGTCAACATATACGGCAAG

GTTTCCCCT AGAGACT ATTT GAGAGGGCTCGC AAGGGGAGT ATT GAT AGGAT

CCTCGATTTGCTTCTTGACAAGAATGACAAATATCAATATTAATAGACCTCTT

GAATTGGTCTCAGGGGTAATCTCATATATTCTCCTGAGGCTAGATAACCATCC

CTCCTTGTACATAATGCTCAGAGAACCGTCTCTTAGAGGAGAGATATTTTCTA

TCCCTCAGAAAATCCCCGCCGCTTATCCAACCACTATGAAAGAAGGCAACAG

ATCAATCTTGTGTTATCTCCAACATGTGCTACGCTATGAGCGAGAGATAATCA

CGGCGTCTCCAGAGAATGACTGGCTATGGATCTTTTCAGACTTTAGAAGTGCC

AAAATGACGTACCTATCCCTCATTACTTACCAGTCTCATCTTCTACTCCAGAG

GGTTGAGAGAAACCTATCTAAGAGTATGAGAGATAACCTGCGACAATTGAGT

TCTTTGATGAGGCAGGTGCTGGGCGGGCACGGAGAAGATACCTTAGAGTCAG

ACGACAACATTCAACGACTGCTAAAAGACTCTTTACGAAGGACAAGATGGGT

GGATCAAGAGGTGCGCCATGCAGCTAGAACCATGACTGGAGATTACAGCCCC

AAC AAGAAGGT GTCCCGT AAGGT AGGAT GTTC AGAATGGGTCTGCTCTGCTC

AACAGGTTGCAGTCTCTACCTCAGCAAACCCGGCCCCTGTCTCGGAGCTTGAC

ATAAGGGCCCTCTCTAAGAGGTTCCAGAACCCTTTGATCTCGGGCTTGAGAGT

GGTTCAGTGGGCAACCGGTGCTCATTATAAGCTTAAGCCTATTCTAGATGATC

TCAATGTTTTCCCATCTCTCTGCCTTGTAGTTGGGGACGGGTCAGGGGGGATA

TCAAGGGCAGTCCTCAACATGTTTCCAGATGCCAAGCTTGTGTTCAACAGTCT

TTTAGAGGTGAATGACCTGATGGCTTCCGGAACACATCCACTGCCTCCTTCAG

CAATCATGAGGGGAGGAAATGATATCGTCTCCAGAGTGATAGATCTTGACTC AATCTGGGAAAAACCGTCCGACTTGAGAAACTTGGCAACCTGGAAATACTTC

CAGTCAGTCCAAAAGCAGGTCAACATGTCCTATGACCTCATTATTTGCGATGC

AGAAGTTACTGACATTGCATCTATCAACCGGATCACCCTGTTAATGTCCGATT

TTGCATTGTCTATAGATGGACCACTCTATTTGGTCTTCAAAACTTATGGGACT

ATGCTAGTAAATCCAAACTACAAGGCTATTCAACACCTGTCAAGAGCGTTCC

CCTCGGTCACAGGGTTTATCACCCAAGTAACTTCGTCTTTTTCATCTGAGCTCT

ACCTCCGATTCTCCAAACGAGGGAAGTTTTTCAGAGATGCTGAGTACTTGACC

TCTTCCACCCTTCGAGAAATGAGCCTTGTGTTATTCAATTGTAGCAGCCCCAA

G AGT GAG AT GC AG AG AGC T C GT TC C TT G A AC TAT C AGG AT C T T GT G AG AGG A

TTTCCTGAAGAAATCATATCAAATCCTTACAATGAGATGATCATAACTCTGAT

TGACAGTGATGTAGAATCTTTTCTAGTCCACAAGATGGTTGATGATCTTGAGT

T AC AGAGGGGA AC TC T GTCT A A AGT GGCT ATC ATT AT AGC CAT CAT GAT AGTT

TTCTCCAACAGAGTCTTCAACGTTTCCAAACCCCTAACTGACCCCTCGTTCTA

TCCACCGTCTGATCCCAAAATCCTGAGGCACTTCAACATATGTTGCAGTACTA

TGATGTATCTATCTACTGCTTTAGGTGACGTCCCTAGCTTCGCAAGACTTCAC

GACCTGTATAACAGACCTATAACTTATTACTTCAGAAAGCAAGTCATTCGAG

GGA AC GTTT ATCT ATCTT GGAGTT GGT C C A AC GAC AC CTC AGT GTT C A A A AGG

GTAGCCTGTAATTCTAGCCTGAGTCTGTCATCTCACTGGATCAGGTTGATTTA

C AAGAT AGTGAAGACT ACC AGACTCGTT GGC AGC AT C AAGGATCT ATCC AGA

GAAGTGGAAAGACACCTTCATAGGTACAACAGGTGGATCACCCTAGAGGATA

TCAGATCTAGATCATCCCTACTAGACTACAGTTGCCTGTGAACCGGATACTCC

TGGAAGCCTGCCCATGCTAAGACTCTTGTGTGATGTATCTTGAAAAAAACAA

GATCCTAAATCTGAACCTTTGGTTGTTTGATTGTTTTTCTCAtttttgttgtttatttgttaagc gt-

In one embodiment, the nucleic acid comprises the sequence of SEQ ID NO: 10, shown below (RABV vector: Coravax V3-China (S1-VSVG-E26)): ACGCTTAACAACCAGATCAAAGAAAAAACAGACATTGTCAATTGCAAAGCAA AAATGTAACACCCCTACAATGGATGCCGACAAGATTGTATTCAAAGTCAATA AT C AGGT GGT C TC TT T G A AGC C T GAG AT T AT C GT GG AT C A AT AT G AGT AC A AG TACCCTGCCATCAAAGATTTGAAAAAGCCCTGTATAACCCTAGGAAAGGCTC CCGATTTAAATAAAGCATACAAGTCAGTTTTGTCAGGCATGAGCGCCGCCAA ACTTAATCCTGACGATGTATGTTCCTATTTGGCAGCGGCAATGCAGTTTTTTG AGGGGACATGTCCGGAAGACTGGACCAGCTATGGAATTGTGATTGCACGAAA AGGAGATAAGATCACCCCAGGTTCTCTGGTGGAGATAAAACGTACTGATGTA GAAGGGAATT GGGCTCTGAC AGGAGGC AT GGAACTGAC AAGAGACCCC ACT

GTCCCTGAGCATGCGTCCTTAGTCGGTCTTCTCTTGAGTCTGTATAGGTTGAG

CAAAATATCCGGGCAAAACACTGGTAACTATAAGACAAACATTGCAGACAGG

ATAGAGCAGATTTTTGAGACAGCCCCTTTTGTTAAAATCGTGGAACACCATAC

TC T A AT GAC A AC TC AC A Aa AT GT GT GCT A ATT GGAGT ACT AT AC C A A AC TTC A

GATTTTTGGCCGGAACCTATGACATGTTTTTCTCCCGGATTGAGCATCTATATT

CAGCAATCAGAGTGGGCACAGTTGTCACTGCTTATGAAGACTGTTCAGGACT

GGTATCATTTACTGGGTTCATAAAACAAATCAATCTCACCGCTAGAGAGGCA

ATACTATATTTCTTCCACAAGAACTTTGAGGAAGAGATAAGAAGAATGTTTG

AGCCAGGGCAGGAGACAGCTGTTCCTCACTCTTATTTCATCCACTTCCGTTCA

CTAGGCTTGAGTGGGAAATCTCCTTATTCATCAAATGCTGTTGGTCACGTGTT

CAATCTCATTCACTTTGTAGGATGCTATATGGGTCAAGTCAGATCCCTAAATG

CAACGGTTATTGCTGCATGTGCTCCTCATGAAATGTCTGTTCTAGGGGGCTAT

CTGGGAGAGGAATTCTTCGGGAAAGGGAC ATTTGAAAGAAGATTCTTC AGAG

AT GAG A A AG A AC TT C A AG A AT AC G AGGC GGC T G A AC T GAC A A AG AC T GAC G

TAGCACTGGCAGATGATGGAACTGTCAACTCTGACGACGAGGACTACTTTTC

AGGT GAAACC AGAAGTCCGGAGGCTGTTT AT ACTCGAAT CAT GAT GAAT GGA

GGTCGACTAAAGAGATCTCACATACGGAGATATGTCTCAGTCAGTTCCAATC

ATCAAGCCCGTCCAAACTCATTCGCCGAGTTTCTAAACAAGACATATTCGAGT

GACTCATAAcatgaaaaaaactaacacccctcccGTACGCCACCATGTTCGTGTTTCTGGTG

CTGCTGCCTCTGGTGAGCTCCCAGTGCGTGAACCTGACCACAAGGACCCAGC

TGCCCCCTGCCTATACCAATTCCTTCACACGGGGCGTGTACTATCCCGACAAG

GTGTTCCGGAGCAGCGTGCTGCACTCCACACAGGATCTGTTTCTGCCTTTCTT

TTCTAACGTGACCTGGTTCCACGCCATCCACGTGAGCGGCACCAATGGCACA

AAGCGGTTCGACAATCCAGTGCTGCCCTTTAACGATGGCGTGTACTTCGCCTC

CACCGAGAAGTCTAACATCATCAGAGGCTGGATCTTTGGCACCACACTGGAC

AGCAAGACACAGTCCCTGCTGATCGTGAACAATGCCACCAACGTGGTCATCA

AGGTGTGCGAGTTCCAGTTTTGTAATGATCCATTCCTGGGCGTGTACTATCAC

AAGAACAATAAGTCTTGGATGGAGAGCGAGTTTCGCGTGTATTCCTCTGCCA

ACAATTGCACATTTGAGTACGTGTCCCAGCCCTTCCTGATGGACCTGGAGGGC

AAGCAGGGCAATTTCAAGAACCTGAGGGAGTTCGTGTTTAAGAATATCGATG

GCTACTTCAAAATCTACTCCAAGCACACCCCAATCAACCTGGTGCGCGACCTG

CCACAGGGCTTCTCTGCCCTGGAGCCACTGGTGGATCTGCCCATCGGCATCAA

CATCACCCGGTTTCAGACACTGCTGGCCCTGCACAGAAGCTACCTGACACCA GGCGACAGCTCCTCTGGATGGACCGCAGGAGCAGCAGCCTACTATGTGGGCT

ATCTGCAGCCCAGGACCTTCCTGCTGAAGTACAACGAGAATGGCACCATCAC

AGACGCCGTGGATTGCGCCCTGGATCCCCTGTCTGAGACCAAGTGTACACTG

AAGAGCTTTACCGTGGAGAAGGGCATCTATCAGACAAGCAATTTCAGGGTGC

AGCCTACCGAGTCCATCGTGCGCTTTCCCAATATCACAAACCTGTGCCCTTTT

GGCGAGGTGTTCAACGCAACCCGCTTCGCCAGCGTGTACGCCTGGAATAGGA

AGCGCATCTCCAACTGCGTGGCCGACTATTCTGTGCTGTACAACAGCGCCTCC

TTCTCTACCTTTAAGTGCTATGGCGTGAGCCCCACAAAGCTGAATGACCTGTG

CTTTACCAACGTGTACGCCGATTCCTTCGTGATCAGGGGCGACGAGGTGCGCC

AGATCGCACCAGGACAGACAGGCAAGATCGCAGACTACAATTATAAGCTGCC

TGACGATTTCACCGGCTGCGTGATCGCCTGGAACTCTAACAATCTGGATAGCA

AAGTGGGCGGCAACTACAATTATCTGTACCGGCTGTTTAGAAAGTCTAATCTG

AAGCCATTCGAGAGGGACATCTCCACAGAAATCTACCAGGCCGGCTCTACCC

CCTGCAATGGCGTGGAGGGCTTTAACTGTTATTTCCCTCTGCAGAGCTACGGC

TTCCAGCCAACAAACGGCGTGGGCTATCAGCCCTACCGCGTGGTGGTGCTGT

CTTTTGAGCTGCTGCACGCACCTGCAACAGTGTGCGGACCAAAGAAGAGCAC

CAATCTGGTGAAGAACAAGTGCGTGAACTTCAACTTCAACGGACTGACCGGA

ACAGGCGTGCTGACCGAGTCCAACAAGAAGTTCCTGCCTTTTCAGCAGTTCG

GCAGGGACATCGCAGATACCACAGACGCCGTGCGCGACCCTCAGACCCTGGA

GATCCTGGACATCACACCATGCTCCTTCGGCGGCGTGTCTGTGATCACACCAG

GC AC C A AT AC A AGC A AC C AGGT GGCC GT GC T GT AT C AGGAC GT GA ATT GT AC

CGAGGTGCCAGTGGCAATCCACGCAGATCAGCTGACCCCTACATGGCGGGTG

TACTCTACCGGCAGCAACGTGTTCCAGACAAGAGCCGGATGCCTGATCGGAG

CAGAGCACGTGAACAATAGCTATGAGTGCGACATCCCTATCGGCGCCGGCAT

CTGTGCCTCCTACCAGACCCAGACAAACTCCCCAAGGTCTGTGGGCGATACA

GGCCTGTCCAAGAATCCAATCGAGCTGGTAGAGGGCTGGTTCAGCAGTTGGA

AAAGCTCCATCGCCTCCTTTTTCTTTATCATCGGCCTGATCATCGGACTGTTCC

TGGTGCTCCGCGTGGGTATCCACCTGTGCATCAAGCTGAAGCACACCAAGAA

AAGACAGATTTATACAGACATCGAGATGAACCGCCTGGGAAAGTGAGCTAGC

CATGAAAAAAACTAACACCCCTCCTTTCGAACCATCCCAAACATGAGCAAGA

TCTTTGTCAATCCTAGTGCTATTAGAGCCGGTCTGGCCGATCTTGAGATGGCT

GAAGAAACTGTTGATCTGATCAATAGAAATATCGAAGACAATCAGGCTCATC

TCCAAGGGGAACCCATAGAGGTGGACAATCTCCCTGAGGATATGGGGCGACT

TC ACC T GGAT GAT GGA A A AT C GCC C A AC CAT GGT GAGAT AGCC A AGGT GGGA GAAGGCAAGTATCGAGAGGACTTTCAGATGGATGAAGGAGAGGATCCTAGCT

TCCTGTTCCAGTCATACCTGGAAAATGTTGGAGTCCAAATAGTCAGACAAAT

GAGGT C AGGAGAGAGATTTCTC AAGAT AT GGT C AC AGACCGT AGAAGAGATT

ATATCCTATGTCGCGGTCAACTTTCCCAACCCTCCAGGAAAGTCTTCAGAGGA

TAAATCAACCCAGACTACTGGCCGAGAGCTCAAGAAGGAGACAACACCCACT

CCTTCTCAGAGAGAAAGCCAATCATCGAAAGCCAGGATGGCGGCTCAAATTG

CTTCTGGCCCTCCAGCCCTTGAATGGTCGGCTACCAATGAAGAGGATGATCTA

TCAGTGGAGGCTGAGATCGCTCACCAGATTGCAGAAAGTTTCTCCAAAAAAT

ATAAGTTTCCCTCTCGATCCTCAGGGATACTCTTGTATAATTTTGAGCAATTG

A A A AT GA ACC TT GAT GAT AT AGTT A A AG AGGC A A A A A AT GT ACC AGGT GT GA

CCCGTTTAGCCCATGACGGGTCCAAACTCCCCCTAAGATGTGTACTGGGATGG

GTCGCTTTGGCCAACTCTAAGAAATTCCAGTTGTTAGTCGAATCCGACAAGCT

GAGTAAAATCATGCAAGATGACTTGAATCGCTATACATCTTGCTAACCGAAC

CTCTCCCCTCAGTCCCTCTAGACAATAAAATCCGAGATGTCCCAAAGTCAACA

TGAAAAAAACAGGCAACACCACTGATAAAATGAACCTCCTACGTAAGATAGT

GAAAAACCGCAGGGACGAGGACACTCAAAAATCCTCTCCCGCGTCAGCCCCT

CTGGATGACGATGACTTGTGGCTTCCACCCCCTGAATACGTCCCGCTGAAAGA

ACTTACAGGCAAGAAGAACATGAGGAACTTTTGTATCAACGGAAGGGTTAAA

GTGTGTAGCCCGAATGGTTACTCGTTCAGGATCCTGCGGCACATTCTGAAATC

ATTC GACGAGAT AT ATTCTGGGA AT CAT AGGAT GAT C GGGTT AGT C A A AGT G

GTTATTGGACTGGCTTTGTCAGGATCTCCAGTCCCTGAGGGCCTGAACTGGGT

ATACAAATTGAGGAGAACCTTTATCTTCCAGTGGGCTGATTCCAGGGGCCCTC

TTGAAGGGGAGGAGTTGGAATACTCTCAGGAGATCACTTGGGATGATGATAC

T GAGTTCGTCGGATTGC AAAT AAGAGT GATT GC AAAAC AGT GTC AT ATCC AG

GGCAGAGTCTGGTGTATCAACATGAACCCGAGAGCATGTCAACTATGGTCTG

ACATGTCTCTTCAGACACAAAGGTCCGAAGAGGACAAAGATTCCTCTCTGCTT

CTAGAATAATCAGATTATATCCCGCAAATTTATCACTTGTTTACCTCTGGAGG

AGAGA AC AT AT GGGC T C A ACTCC A AC CC TT GGGAGC A AT AT A AC A A A A A AC A

TGTTATGGTGCCATTAAACCGCTGCATTTCATCAAAGTCAAGTTGATTACCTT

TACATTTTGATCCTCTTGGATGTGAAAAAAACTATTAACATCCCTCAAAAGAC cccgggAAAGATGGTTCCTCAGGCTCTCCTGTTTGTACCCCTTCTGGTTTTTCCAT

TGTGTTTTGGGAAATTCCCTATTTACACGATACCAGACAAGCTTGGTCCCTGG

AGTCCGATTGACATACATCACCTCAGCTGCCCAAACAATTTGGTAGTGGAGG

ACGAAGGATGCACCAACCTGTCAGGGTTCTCCTACATGGAACTTAAAGTTGG ATACATCTTAGCCATAAAAGTGAACGGGTTCACTTGCACAGGCGTTGTGACG

GAGGCTGAAACCTACACTAACTTCGTTGGTTATGTCACAACCACGTTCAAAA

GAAAGCATTTCCGCCCAACACCAGATGCATGTAGAGCCGCGTACAACTGGAA

GATGGCCGGTGACCCCAGATATGAAGAGTCTCTACACAATCCGTACCCTGAC

TACCGCTGGCTTCGAACTGTAAAAACCACCAAGGAGTCTCTCGTTATCATATC

TCCAAGTGTGGCAGATTTGGACCCATATGACAGATCCCTTCACTCGAGGGTCT

TCCCTAGCGGGAAGTGCTCAGGAGTAGCGGTGTCTTCTACCTACTGCTCCACT

AACCACGATTACACCATTTGGATGCCCGAGAATCCGAGACTAGGGATGTCTT

GTGACATTTTTACCAATAGTAGAGGGAAGAGAGCATCCAAAGGGAGTGAGAC

TTGCGGCTTTGTAGATGAAAGAGGCCTATATAAGTCTTTAAAAGGAGCATGC

AAACTCAAGTTATGTGGAGTTCTAGGACTTAGACTTATGGATGGAACATGGG

TCTCGATGCAAACATCAAATGAAACCAAATGGTGCCCTCCCGATAAGTTGGT

GAACCTGCACGACTTTCGCTCAGACGAAATTGAGCACCTTGTTGTAGAGGAG

TTGGTCAGGAAGAGAGAGGAGTGTCTGGATGCACTAGAGTCCATCATGACAA

CCAAGTCAGTGAGTTTCAGACGTCTCAGTCATTTAAGAAAACTTGTCCCTGGG

TTTGGAAAAGCATATACCATATTCAACAAGACCTTGATGGAAGCCGATGCTC

ACTACAAGTCAGTCgagACTTGGAATGAGATCCTCCCTTCAAAAGGGTGTTTA

AGAGTTGGGGGGAGGTGTCATCCTCATGTGAACGGGGTGTTTTTCAATGGTAT

AATATTAGGACCTGACGGCAATGTCTTAATCCCAGAGATGCAATCATCCCTCC

TCCAGCAACATATGGAGTTGTTGGAATCCTCGGTTATCCCCCTTGTGCACCCC

CTGGCAGACCCGTCTACCGTTTTCAAGGACGGTGACGAGGCTGAGGATTTTGT

TGAAGTTCACCTTCCCGATGTGCACAATCAGGTCTCAGGAGTTGACTTGGGTC

TCCCGAACTGGGGGAAGT ATGT ATT ACTGAGT GC AGGGGCCCTGACTGCCTT

GATGTTGATAATTTTCCTGATGACATGTTGTAGAAGAGTCAATCGATCAGAAC

CTACGCAACACAATCTCAGAGGGACAGGGAGGGAGGTGTCAGTCACTCCCCA

AAGCGGGAAGAT CAT ATCTTC ATGGGAAT C AC AC A AGAGTGGGGGTGAGACC

AG AC T GT A AttaattaaC GT C CTTT C A AC GATCC A AGT C catgaaaaaaactaacacccctcccgta cctagcTTATAAAGTGCTGGGTCATCTAAGCTTTTCAGTCGAGAAAAAAACATTA

GATCAGAAGAACAACTGGCAACACTTCTCAACCTGAGACTTACTTCAAGATG

CTCGATCCTGGAGAGGTCTATGATGACCCTATTGACCCAATCGAGTTAGAGG

CTGAACCCAGAGGAACCCCCATTGTCCCCAACATCTTGAGGAACTCTGACTA

CAATCTCAACTCTCCTTTGATAGAAGATCCTGCTAGACTAATGTTAGAATGGT

TAAAAACAGGGAATAGACCTTATCGGATGACTCTAACAGACAATTGCTCCAG

GTCTTTCAGAGTTTTGAAAGATTATTTCAAGAAGGTAGATTTGGGTTCTCTCA AGGT GGGCGGAAT GGCTGC AC AGT C AAT GATTTCTCTCTGGTT AT ATGGT GCC

CACTCTGAATCCAACAGGAGCCGGAGATGTATAACAGACTTGGCCCATTTCT

ATTCCAAGTCGTCCCCCATAGAGAAGCTGTTGAATCTCACGCTAGGAAATAG

AGGGCTGAGAATCCCCCCAGAGGGAGTGTTAAGTTGCCTTGAGAGGGTTGAT

TATGATAATGCATTTGGAAGGTATCTTGCCAACACGTATTCCTCTTACTTGTTC

TTCC ATGT AAT C ACCTT AT AC AT GAACGCCCT AGACTGGGAT GAAGAAAAGA

CCATCCTAGCATTATGGAAAGATTTAACCTCAGTGGACATCGGGAAGGACTT

GGTAAAGTTCAAAGACCAAATATGGGGACTGCTGATCGTGACAAAGGACTTT

GTTTACTCCCAAAGTTCCAATTGTCTTTTTGACAGAAACTACACACTTATGCT

AAAAGATCTTTTCTTGTCTCGCTTCAACTCCTTAATGGTCTTGCTCTCTCCCCC

AGAGCCCCGATACTCAGATGACTTGATATCTCAACTATGCCAGCTGTACATTG

CTGGGGATCAAGTCTTGTCTATGTGTGGAAACTCCGGCTATGAAGTCATCAAA

AT ATT GGAGCC AT ATGTCGT GAAT AGTTT AGTCC AGAGAGC AGAAAAGTTT A

GGCCTCTCATTCATTCCTTGGGAGACTTTCCTGTATTTATAAAAGACAAGGTA

AGTCAACTTGAAGAGACGTTCGGTCCCTGTGCAAGAAGGTTCTTTAGGGCTCT

GGATCAATTCGACAACATACATGACTTGGTTTTTGTGTTTGGCTGTTACAGGC

ATTGGGGGCACCCATATATAGATTATCGAAAGGGTCTGTCAAAACTATATGA

TCAGGTTCACCTTAAAAAAATGATAGATAAGTCCTACCAGGAGTGCTTAGCA

AGCGACCTAGCCAGGAGGATCCTTAGATGGGGTTTTGATAAGTACTCCAAGT

GGTATCTGGATTCAAGATTCCTAGCCCGAGACCACCCCTTGACTCCTTATATC

AAAACCCAAACATGGCCACCCAAACATATTGTAGACTTGGTGGGGGATACAT

GGCACAAGCTCCCGATCACGCAGATCTTTGAGATTCCTGAATCAATGGATCC

GTCAGAAATATTGGATGACAAATCACATTCTTTCACCAGAACGAGACTAGCT

TCTT GGCTGTC AGAAAACCGAGGGGGGCCTGTTCCT AGCGAAA AAGTT ATT A

TCACGGCCCTGTCTAAGCCGCCTGTCAATCCCCGAGAGTTTCTGAGGTCTATA

GACCTCGGAGGATTGCCAGATGAAGACTTGATAATTGGCCTCAAGCCAAAGG

AACGGGAATTGAAGATTGAAGGTCGATTCTTTGCTCTAATGTCATGGAATCTA

AGATTGTATTTTGTCATCACTGAAAAACTCTTGGCCAACTACATCTTGCCACT

TTTTGACGCGCTGACTATGACAGACAACCTGAACAAGGTGTTTAAAAAGCTG

ATCGACAGGGTCACCGGGCAAGGGCTTTTGGACTATTCAAGGGTCACATATG

C ATTTC ACCTGGACT AT GAAAAGT GGAAC AACC AT C AAAGATT AG AGT C AAC

AGAGGAT GT ATTTTCTGTCCT AGAT C AAGT GTTTGGATT GAAGAGAGTGTTTT

CTAGAACACACGAGTTTTTTCAAAAGGCCTGGATCTATTATTCAGACAGATCA

GACCTCATCGGGTTACGGGAGGATCAAATATACTGCTTAGATGCGTCCAACG GCCCAACCTGTTGGAATGGCCAGGATGGCGGGCTAGAAGGCTTACGGCAGAA

GGGCTGGAGTCT AGT C AGCTT ATT GAT GAT AG AT AGAGAATCTC AAAT C AGG

AAC AC AAGAACC AAAAT ACT AGCTC A AGGAGAC AACC AGGTTTT ATGTCCGA

CATACATGTTGTCGCCAGGGCTATCTCAAGAGGGGCTCCTCTATGAATTGGAG

AG A AT AT C A AGG A AT GC AC TTTC GAT AT AC AGAGCC GT C GAGGA AGGGGC AT

CTAAGCTAGGGCTGATCATCAAGAAAGAAGAGACCATGTGTAGTTATGACTT

CCTCATCTATGGAAAAACCCCTTTGTTTAGAGGTAACATATTGGTGCCTGAGT

CCAAAAGATGGGCCAGAGTCTCTTGCGTCTCTAATGACCAAATAGTCAACCT

CGCCAATATAATGTCGACAGTGTCCACCAATGCGCTAACAGTGGCACAACAC

TCTCAATCTTTGATCAAACCGATGAGGGATTTTCTGCTCATGTCAGTACAGGC

AGTCTTTCACTACCTGCTATTTAGCCCAATCTTAAAGGGAAGAGTTTACAAGA

TTCTGAGCGCTGAAGGGGAGAGCTTTCTCCTAGCCATGTCAAGGATAATCTAT

CTAGATCCTTCTTTGGGAGGGATATCTGGAATGTCCCTCGGAAGATTCCATAT

ACGACAGTTCTCAGACCCTGTCTCTGAAGGGTTATCCTTCTGGAGAGAGATCT

GGTTAAGCTCCCAAGAGTCCTGGATTCACGCGTTGTGTCAAGAGGCTGGAAA

CCCAGATCTTGGAGAGAGAACACTCGAGAGCTTCACTCGCCTTCTAGAAGAT

CCGACCACCTTAAATATCAGAGGAGGGGCCAGTCCTACCATTCTACTCAAGG

AT GC AAT C AGA AAGGCTTT AT ATGACGAGGT GGAC AAGGTGGAAAATTC AGA

GTTTCGAGAGGCAATCCTGTTGTCCAAGACCCATAGAGATAATTTTATACTCT

TCTTAATATCTGTTGAGCCTCTGTTTCCTCGATTTCTCAGTGAGCTATTCAGTT

CGTCTTTTTTGGGAATCCCCGAGTCAATCATTGGATTGATACAAAACTCCCGA

AC GAT A AGA AGGC AGTTT AGA A AGAGT C TC T C A A A A AC TTT AGA AG A AT C CT

TCTACAACTCAGAGATCCACGGGATTAGTCGGATGACCCAGACACCTCAGAG

GGTTGGGGGGGTGT GGCCTT GCTCTTC AGAGAGGGC AGATCT ACTT AGGGAG

ATCTCTTGGGGAAGAAAAGTGGTAGGCACGACAGTTCCTCACCCTTCTGAGA

TGTTGGGATTACTTCCCAAGTCCTCTATTTCTTGCACTTGTGGAGCAACAGGA

GGAGGCAATCCTAGAGTTTCTGTATCAGTACTCCCGTCCTTTGATCAGTCATT

TTTTTCACGAGGCCCCCTAAAGGGATACTTGGGCTCGTCCACCTCTATGTCGA

C C C AGC TATTCCAT GC AT GGG A A A A AGT C AC T AAT GT TC AT GT GGT G A AG AG

AGCTCTATCGTTAAAAGAATCTATAAACTGGTTCATTACTAGAGATTCCAACT

TGGCTCAAGCTCTAATTAGGAACATTATGTCTCTGACAGGCCCTGATTTCCCT

CTAGAGGAGGCCCCTGTCTTCAAAAGGACGGGGTCAGCCTTGCATAGGTTCA

AGTCTGCCAGATACAGCGAAGGAGGGTATTCTTCTGTCTGCCCGAACCTCCTC

TCTCATATTTCTGTTAGTACAGACACCATGTCTGATTTGACCCAAGACGGGAA GAACTACGATTTCATGTTCCAGCCATTGATGCTTTATGCACAGACATGGACAT

CAGAGCTGGTACAGAGAGACACAAGGCTAAGAGACTCTACGTTTCATTGGCA

CCTCCGATGCAACAGGTGTGTGAGACCCATTGACGACGTGACCCTGGAGACC

TCTCAGATCTTCGAGTTTCCGGATGTGTCGAAAAGAATATCCAGAATGGTTTC

TGGGGCTGTGCCTCACTTCCAGAGGCTTCCCGATATCCGTCTGAGACCAGGAG

ATTTTGAATCTCTAAGCGGTAGAGAAAAGTCTCACCATATCGGATCAGCTCA

GGGGCTCTTATACTCAATCTTAGTGGCAATTCACGACTCAGGATACAATGATG

GAACCATCTTCCCTGTCAACATATACGGCAAGGTTTCCCCTAGAGACTATTTG

AGAGGGCTCGCAAGGGGAGTATTGATAGGATCCTCGATTTGCTTCTTGACAA

GAAT GAC AAAT ATC AAT ATT AAT AGACCTCTT GAATT GGTCTC AGGGGT AAT C

TCATATATTCTCCTGAGGCTAGATAACCATCCCTCCTTGTACATAATGCTCAG

AGAACCGTCTCTTAGAGGAGAGATATTTTCTATCCCTCAGAAAATCCCCGCCG

CTTATCCAACCACTATGAAAGAAGGCAACAGATCAATCTTGTGTTATCTCCAA

CAT GT GCT ACGCT AT GAGCGAGAGAT AAT C ACGGCGTCTCC AGAGAAT GACT

GGCTATGGATCTTTTCAGACTTTAGAAGTGCCAAAATGACGTACCTATCCCTC

ATTACTTACCAGTCTCATCTTCTACTCCAGAGGGTTGAGAGAAACCTATCTAA

GAGTATGAGAGATAACCTGCGACAATTGAGTTCTTTGATGAGGCAGGTGCTG

GGC GGGC AC GG AG A AG AT ACC TT AGAGT C AGAC GAC A AC ATT C A AC GACTGC

T AAAAGACTCTTT ACGA AGGAC AAGAT GGGTGGATC A AGAGGT GCGCC ATGC

AGCTAGAACCATGACTGGAGATTACAGCCCCAACAAGAAGGTGTCCCGTAAG

GTAGGATGTTCAGAATGGGTCTGCTCTGCTCAACAGGTTGCAGTCTCTACCTC

AGCAAACCCGGCCCCTGTCTCGGAGCTTGACATAAGGGCCCTCTCTAAGAGG

TTCCAGAACCCTTTGATCTCGGGCTTGAGAGTGGTTCAGTGGGCAACCGGTGC

TCATTATAAGCTTAAGCCTATTCTAGATGATCTCAATGTTTTCCCATCTCTCTG

CCTT GT AGTT GGGGACGGGTC AGGGGGGAT AT C AAGGGC AGTCCTC AAC AT G

TTTCCAGATGCCAAGCTTGTGTTCAACAGTCTTTTAGAGGTGAATGACCTGAT

GGCTTCCGG AAC ACATCCACTGCCTCCTTCAGCAATCATGAGGGGAGG AAAT

GATATCGTCTCCAGAGTGATAGATCTTGACTCAATCTGGGAAAAACCGTCCG

ACTTGAGAAACTTGGCAACCTGGAAATACTTCCAGTCAGTCCAAAAGCAGGT

CAACATGTCCTATGACCTCATTATTTGCGATGCAGAAGTTACTGACATTGCAT

CTATCAACCGGATCACCCTGTTAATGTCCGATTTTGCATTGTCTATAGATGGA

CCACTCTATTTGGTCTTCAAAACTTATGGGACTATGCTAGTAAATCCAAACTA

CAAGGCTATTCAACACCTGTCAAGAGCGTTCCCCTCGGTCACAGGGTTTATCA

CCCAAGTAACTTCGTCTTTTTCATCTGAGCTCTACCTCCGATTCTCCAAACGA GGGAAGTTTTTCAGAGATGCTGAGTACTTGACCTCTTCCACCCTTCGAGAAAT

GAGCCTTGTGTTATTCAATTGTAGCAGCCCCAAGAGTGAGATGCAGAGAGCT

CGTTCCTTGAACTATCAGGATCTTGTGAGAGGATTTCCTGAAGAAATCATATC

AAATCCTTACAATGAGATGATCATAACTCTGATTGACAGTGATGTAGAATCTT

TTCTAGTCCACAAGATGGTTGATGATCTTGAGTTACAGAGGGGAACTCTGTCT

AAAGTGGCTATCATTATAGCCATCATGATAGTTTTCTCCAACAGAGTCTTCAA

CGTTTCCAAACCCCTAACTGACCCCTCGTTCTATCCACCGTCTGATCCCAAAA

TCCTGAGGCACTTCAACATATGTTGCAGTACTATGATGTATCTATCTACTGCT

TTAGGTGACGTCCCTAGCTTCGCAAGACTTCACGACCTGTATAACAGACCTAT

AACTTATTACTTCAGAAAGCAAGTCATTCGAGGGAACGTTTATCTATCTTGGA

GTTGGTCCAACGACACCTCAGTGTTCAAAAGGGTAGCCTGTAATTCTAGCCTG

AGTCTGTCATCTCACTGGATCAGGTTGATTTACAAGATAGTGAAGACTACCAG

ACTCGTTGGCAGCATCAAGGATCTATCCAGAGAAGTGGAAAGACACCTTCAT

AGGTACAACAGGTGGATCACCCTAGAGGATATCAGATCTAGATCATCCCTAC

TAGACTACAGTTGCCTGTGAACCGGATACTCCTGGAAGCCTGCCCATGCTAA

GACTCTTGTGTGATGTATCTTGAAAAAAACAAGATCCTAAATCTGAACCTTTG

GTTGTTTGATTGTTTTTCTCAtttttgttgtttatttgttaagcgt.

In one embodiment, the nucleic acid comprises the sequence of SEQ ID NO: 11, shown below (RABV vector: Coravax V3-South Africa (S1-VSVG-E26)): ACGCTTAACAACCAGATCAAAGAAAAAACAGACATTGTCAATTGCAAAGCAA AAATGTAACACCCCTACAATGGATGCCGACAAGATTGTATTCAAAGTCAATA AT C AGGT GGT C TC TT T G A AGC C T GAG AT T AT C GT GG AT C A AT AT G AGT AC A AG TACCCTGCCATCAAAGATTTGAAAAAGCCCTGTATAACCCTAGGAAAGGCTC CCGATTTAAATAAAGCATACAAGTCAGTTTTGTCAGGCATGAGCGCCGCCAA ACTTAATCCTGACGATGTATGTTCCTATTTGGCAGCGGCAATGCAGTTTTTTG AGGGGACATGTCCGGAAGACTGGACCAGCTATGGAATTGTGATTGCACGAAA AGGAGATAAGATCACCCCAGGTTCTCTGGTGGAGATAAAACGTACTGATGTA GAAGGGAATT GGGCTCTGAC AGGAGGC AT GGAACTGAC AAGAGACCCC ACT GTCCCTGAGCATGCGTCCTTAGTCGGTCTTCTCTTGAGTCTGTATAGGTTGAG CAAAATATCCGGGCAAAACACTGGTAACTATAAGACAAACATTGCAGACAGG ATAGAGCAGATTTTTGAGACAGCCCCTTTTGTTAAAATCGTGGAACACCATAC TC T A AT GAC A AC TC AC A Aa AT GT GT GCT A ATT GGAGT ACT AT AC C A A AC TTC A GATTTTTGGCCGGAACCTATGACATGTTTTTCTCCCGGATTGAGCATCTATATT CAGCAATCAGAGTGGGCACAGTTGTCACTGCTTATGAAGACTGTTCAGGACT GGTATCATTTACTGGGTTCATAAAACAAATCAATCTCACCGCTAGAGAGGCA

ATACTATATTTCTTCCACAAGAACTTTGAGGAAGAGATAAGAAGAATGTTTG

AGCCAGGGCAGGAGACAGCTGTTCCTCACTCTTATTTCATCCACTTCCGTTCA

CTAGGCTTGAGTGGGAAATCTCCTTATTCATCAAATGCTGTTGGTCACGTGTT

CAATCTCATTCACTTTGTAGGATGCTATATGGGTCAAGTCAGATCCCTAAATG

CAACGGTTATTGCTGCATGTGCTCCTCATGAAATGTCTGTTCTAGGGGGCTAT

CTGGGAGAGGAATTCTTCGGGAAAGGGAC ATTTGAAAGAAGATTCTTC AGAG

AT GAG A A AG A AC TT C A AG A AT AC G AGGC GGC T G A AC T G AC A A AG AC T G AC G

TAGCACTGGCAGATGATGGAACTGTCAACTCTGACGACGAGGACTACTTTTC

AGGT GAAACC AGAAGTCCGGAGGCTGTTT AT ACTCGAAT CAT GAT GAAT GGA

GGTCGACTAAAGAGATCTCACATACGGAGATATGTCTCAGTCAGTTCCAATC

ATCAAGCCCGTCCAAACTCATTCGCCGAGTTTCTAAACAAGACATATTCGAGT

GACTCATAAcatgaaaaaaactaacacccctcccGTACGCCACCATGTTCGTGTTTCTGGTG

CTGCTGCCTCTGGTGAGCTCCCAGTGCGTGAACTTCACCACAAGGACCCAGCT

GCCCCCTGCCTATACCAATTCCTTCACACGGGGCGTGTACTATCCCGACAAGG

TGTTCCGGAGCAGCGTGCTGCACTCCACACAGGATCTGTTTCTGCCTTTCTTTT

CTAACGTGACCTGGTTCCACGCCATCCACGTGAGCGGCACCAATGGCACAAA

GCGGTTCGCCAATCCAGTGCTGCCCTTTAACGATGGCGTGTACTTCGCCTCCA

CCGAGAAGTCTAACATCATCAGAGGCTGGATCTTTGGCACCACACTGGACAG

CAAGACACAGTCCCTGCTGATCGTGAACAATGCCACCAACGTGGTCATCAAG

GTGTGCGAGTTCCAGTTTTGTAATGATCCATTCCTGGGCGTGTACTATCACAA

GAACAATAAGTCTTGGATGGAGAGCGAGTTTCGCGTGTATTCCTCTGCCAAC

AATTGCACATTTGAGTACGTGTCCCAGCCCTTCCTGATGGACCTGGAGGGCAA

GC AGGGC AATTT C AAGAACCTGAGGGAGTTCGT GTTT AAGAAT ATCGAT GGC

TACTTCAAAATCTACTCCAAGCACACCCCAATCAACCTGGTGCGCGGCCTGCC

ACAGGGCTTCTCTGCCCTGGAGCCACTGGTGGATCTGCCCATCGGCATCAACA

TCACCCGGTTTCAGACACTGCTGGCCCTGCACAGAAGCTACCTGACACCAGG

CGACAGCTCCTCTGGATGGACCGCAGGAGCAGCAGCCTACTATGTGGGCTAT

CTGCAGCCCAGGACCTTCCTGCTGAAGTACAACGAGAATGGCACCATCACAG

ACGCCGTGGATTGCGCCCTGGATCCCCTGTCTGAGACCAAGTGTACACTGAA

GAGCTTTACCGTGGAGAAGGGCATCTATCAGACAAGCAATTTCAGGGTGCAG

CCTACCGAGTCCATCGTGCGCTTTCCCAATATCACAAACCTGTGCCCTTTTGG

CGAGGTGTTCAACGCAACCCGCTTCGCCAGCGTGTACGCCTGGAATAGGAAG

CGCATCTCCAACTGCGTGGCCGACTATTCTGTGCTGTACAACAGCGCCTCCTT CTCTACCTTTAAGTGCTATGGCGTGAGCCCCACAAAGCTGAATGACCTGTGCT

TTACCAACGTGTACGCCGATTCCTTCGTGATCAGGGGCGACGAGGTGCGCCA

GATCGC ACC AGGAC AGAC AGGC AAT ATCGC AGACT AC AATT AT AAGCTGCCT

GACGATTTCACCGGCTGCGTGATCGCCTGGAACTCTAACAATCTGGATAGCA

AAGTGGGCGGCAACTACAATTATCTGTACCGGCTGTTTAGAAAGTCTAATCTG

AAGCCATTCGAGAGGGACATCTCCACAGAAATCTACCAGGCCGGCTCTACCC

CCTGCAATGGCGTGAAGGGCTTTAACTGTTATTTCCCTCTGCAGAGCTACGGC

TTCCAGCCAACATATGGCGTGGGCTATCAGCCCTACCGCGTGGTGGTGCTGTC

TTTTGAGCTGCTGCACGCACCTGCAACAGTGTGCGGACCAAAGAAGAGCACC

A ATCTGGT GA AGA AC A AGT GCGT GA AC TT C A AC TT C A AC GGACTGACC GGA A

CAGGCGTGCTGACCGAGTCCAACAAGAAGTTCCTGCCTTTTCAGCAGTTCGGC

AGGGACATCGCAGATACCACAGACGCCGTGCGCGACCCTCAGACCCTGGAGA

TCCTGGACATCACACCATGCTCCTTCGGCGGCGTGTCTGTGATCAC ACC AGGC

ACCAATACAAGCAACCAGGTGGCCGTGCTGTATCAGGGCGTGAATTGTACCG

AGGTGCCAGTGGCAATCCACGCAGATCAGCTGACCCCTACATGGCGGGTGTA

CTCTACCGGCAGCAACGTGTTCCAGACAAGAGCCGGATGCCTGATCGGAGCA

GAGCACGTGAACAATAGCTATGAGTGCGACATCCCTATCGGCGCCGGCATCT

GTGCCTCCTACCAGACCCAGACAAACTCCCCAAGGTCTGTGGGCGATACAGG

CCTGTCCAAGAATCCAATCGAGCTGGTAGAGGGCTGGTTCAGCAGTTGGAAA

AGCTCCATCGCCTCCTTTTTCTTTATCATCGGCCTGATCATCGGACTGTTCCTG

GTGCTCCGCGTGGGTATCCACCTGTGCATCAAGCTGAAGCACACCAAGAAAA

GACAGATTTATACAGACATCGAGATGAACCGCCTGGGAAAGTGAGCTAGCCA

TGAAAAAAACTAACACCCCTCCTTTCGAACCATCCCAAACATGAGCAAGATC

TTTGTCAATCCTAGTGCTATTAGAGCCGGTCTGGCCGATCTTGAGATGGCTGA

AGAAACTGTTGATCTGAT C AAT AGAAAT ATCGAAGAC AATC AGGCTC ATCTC

C AAGGGGAACCC AT AGAGGT GGAC AAT CTCCCTGAGGAT AT GGGGCGACTT C

ACCTGGATGATGGAAAATCGCCCAACCATGGTGAGATAGCCAAGGTGGGAG

AAGGC AAGT ATCGAGAGGACTTTC AGAT GGAT GAAGGAGAGGATCCT AGCTT

CCTGTTCCAGTCATACCTGGAAAATGTTGGAGTCCAAATAGTCAGACAAATG

AGGT C AGGAG AGAGATTTC TC A AGAT AT GGT C AC AGAC CGT AGA AGAGATT A

TATCCTATGTCGCGGTCAACTTTCCCAACCCTCCAGGAAAGTCTTCAGAGGAT

AAATCAACCCAGACTACTGGCCGAGAGCTCAAGAAGGAGACAACACCCACTC

CTTCTCAGAGAGAAAGCCAATCATCGAAAGCCAGGATGGCGGCTCAAATTGC

TTCTGGCCCTCCAGCCCTTGAATGGTCGGCTACCAATGAAGAGGATGATCTAT C AGT GGAGGCTGAGATCGCTC ACC AGATTGC AGAAAGTTTCTCC AAAAAAT A

TAAGTTTCCCTCTCGATCCTCAGGGATACTCTTGTATAATTTTGAGCAATTGA

A A AT G A AC C TT GAT GAT AT AGT T A A AG AGGC A A A A A AT GT ACC AGGT GT G AC

CCGTTTAGCCCATGACGGGTCCAAACTCCCCCTAAGATGTGTACTGGGATGG

GTCGCTTTGGCCAACTCTAAGAAATTCCAGTTGTTAGTCGAATCCGACAAGCT

GAGTAAAATCATGCAAGATGACTTGAATCGCTATACATCTTGCTAACCGAAC

CTCTCCCCTCAGTCCCTCTAGACAATAAAATCCGAGATGTCCCAAAGTCAACA

TGAAAAAAACAGGCAACACCACTGATAAAATGAACCTCCTACGTAAGATAGT

GAAAAACCGCAGGGACGAGGACACTCAAAAATCCTCTCCCGCGTCAGCCCCT

CTGGATGACGATGACTTGTGGCTTCCACCCCCTGAATACGTCCCGCTGAAAGA

ACTTACAGGCAAGAAGAACATGAGGAACTTTTGTATCAACGGAAGGGTTAAA

GTGTGTAGCCCGAATGGTTACTCGTTCAGGATCCTGCGGCACATTCTGAAATC

ATTC GACGAGAT AT ATTCTGGGA AT CAT AGGAT GAT C GGGTT AGT C A A AGT G

GTTATTGGACTGGCTTTGTCAGGATCTCCAGTCCCTGAGGGCCTGAACTGGGT

ATACAAATTGAGGAGAACCTTTATCTTCCAGTGGGCTGATTCCAGGGGCCCTC

TTGAAGGGGAGGAGTTGGAATACTCTCAGGAGATCACTTGGGATGATGATAC

T GAGTTCGTCGGATTGC AAAT AAGAGT GATT GC AAAAC AGT GTC AT ATCC AG

GGCAGAGTCTGGTGTATCAACATGAACCCGAGAGCATGTCAACTATGGTCTG

ACATGTCTCTTCAGACACAAAGGTCCGAAGAGGACAAAGATTCCTCTCTGCTT

CTAGAATAATCAGATTATATCCCGCAAATTTATCACTTGTTTACCTCTGGAGG

AGAGA AC AT AT GGGC T C A ACTCC A AC CC TT GGGAGC A AT AT A AC A A A A A AC A

TGTTATGGTGCCATTAAACCGCTGCATTTCATCAAAGTCAAGTTGATTACCTT

TACATTTTGATCCTCTTGGATGTGAAAAAAACTATTAACATCCCTCAAAAGAC cccgggAAAGATGGTTCCTCAGGCTCTCCTGTTTGTACCCCTTCTGGTTTTTCCAT

TGTGTTTTGGGAAATTCCCTATTTACACGATACCAGACAAGCTTGGTCCCTGG

AGTCCGATTGACATACATCACCTCAGCTGCCCAAACAATTTGGTAGTGGAGG

ACGAAGGATGCACCAACCTGTCAGGGTTCTCCTACATGGAACTTAAAGTTGG

ATACATCTTAGCCATAAAAGTGAACGGGTTCACTTGCACAGGCGTTGTGACG

GAGGCTGAAACCTACACTAACTTCGTTGGTTATGTCACAACCACGTTCAAAA

GAAAGCATTTCCGCCCAACACCAGATGCATGTAGAGCCGCGTACAACTGGAA

GATGGCCGGTGACCCCAGATATGAAGAGTCTCTACACAATCCGTACCCTGAC

TACCGCTGGCTTCGAACTGTAAAAACCACCAAGGAGTCTCTCGTTATCATATC

TCCAAGTGTGGCAGATTTGGACCCATATGACAGATCCCTTCACTCGAGGGTCT

TCCCTAGCGGGAAGTGCTCAGGAGTAGCGGTGTCTTCTACCTACTGCTCCACT AACCACGATTACACCATTTGGATGCCCGAGAATCCGAGACTAGGGATGTCTT

GTGACATTTTTACCAATAGTAGAGGGAAGAGAGCATCCAAAGGGAGTGAGAC

TTGCGGCTTTGTAGATGAAAGAGGCCTATATAAGTCTTTAAAAGGAGCATGC

AAACTCAAGTTATGTGGAGTTCTAGGACTTAGACTTATGGATGGAACATGGG

TCTCGATGCAAACATCAAATGAAACCAAATGGTGCCCTCCCGATAAGTTGGT

GAACCTGCACGACTTTCGCTCAGACGAAATTGAGCACCTTGTTGTAGAGGAG

TTGGTCAGGAAGAGAGAGGAGTGTCTGGATGCACTAGAGTCCATCATGACAA

CCAAGTCAGTGAGTTTCAGACGTCTCAGTCATTTAAGAAAACTTGTCCCTGGG

TTTGGAAAAGCATATACCATATTCAACAAGACCTTGATGGAAGCCGATGCTC

ACTACAAGTCAGTCgagACTTGGAATGAGATCCTCCCTTCAAAAGGGTGTTTA

AGAGTTGGGGGGAGGTGTCATCCTCATGTGAACGGGGTGTTTTTCAATGGTAT

AATATTAGGACCTGACGGCAATGTCTTAATCCCAGAGATGCAATCATCCCTCC

TCCAGCAACATATGGAGTTGTTGGAATCCTCGGTTATCCCCCTTGTGCACCCC

CTGGCAGACCCGTCTACCGTTTTCAAGGACGGTGACGAGGCTGAGGATTTTGT

TGAAGTTCACCTTCCCGATGTGCACAATCAGGTCTCAGGAGTTGACTTGGGTC

TCCCGAACTGGGGGAAGT ATGT ATT ACTGAGT GC AGGGGCCCTGACTGCCTT

GATGTTGATAATTTTCCTGATGACATGTTGTAGAAGAGTCAATCGATCAGAAC

CTACGCAACACAATCTCAGAGGGACAGGGAGGGAGGTGTCAGTCACTCCCCA

AAGCGGGAAGAT CAT ATCTTC ATGGGAAT C AC AC A AGAGTGGGGGTGAGACC

AG AC T GT A AttaattaaC GT C CTTT C A AC GATCC A AGT C catgaaaaaaactaacacccctcccgta cctagcTTATAAAGTGCTGGGTCATCTAAGCTTTTCAGTCGAGAAAAAAACATTA

GATCAGAAGAACAACTGGCAACACTTCTCAACCTGAGACTTACTTCAAGATG

CTCGATCCTGGAGAGGTCTATGATGACCCTATTGACCCAATCGAGTTAGAGG

CTGAACCCAGAGGAACCCCCATTGTCCCCAACATCTTGAGGAACTCTGACTA

CAATCTCAACTCTCCTTTGATAGAAGATCCTGCTAGACTAATGTTAGAATGGT

TAAAAACAGGGAATAGACCTTATCGGATGACTCTAACAGACAATTGCTCCAG

GTCTTTCAGAGTTTTGAAAGATTATTTCAAGAAGGTAGATTTGGGTTCTCTCA

AGGT GGGCGGAAT GGCTGC AC AGT C AAT GATTTCTCTCTGGTT AT ATGGT GCC

CACTCTGAATCCAACAGGAGCCGGAGATGTATAACAGACTTGGCCCATTTCT

ATTCCAAGTCGTCCCCCATAGAGAAGCTGTTGAATCTCACGCTAGGAAATAG

AGGGCTGAGAATCCCCCCAGAGGGAGTGTTAAGTTGCCTTGAGAGGGTTGAT

TATGATAATGCATTTGGAAGGTATCTTGCCAACACGTATTCCTCTTACTTGTTC

TTCC ATGT AAT C ACCTT AT AC AT GAACGCCCT AGACTGGGAT GAAGAAAAGA

CCATCCTAGCATTATGGAAAGATTTAACCTCAGTGGACATCGGGAAGGACTT GGTAAAGTTCAAAGACCAAATATGGGGACTGCTGATCGTGACAAAGGACTTT

GTTTACTCCCAAAGTTCCAATTGTCTTTTTGACAGAAACTACACACTTATGCT

AAAAGATCTTTTCTTGTCTCGCTTCAACTCCTTAATGGTCTTGCTCTCTCCCCC

AGAGCCCCGATACTCAGATGACTTGATATCTCAACTATGCCAGCTGTACATTG

CTGGGGATCAAGTCTTGTCTATGTGTGGAAACTCCGGCTATGAAGTCATCAAA

AT ATT GGAGCC AT ATGTCGT GAAT AGTTT AGTCC AGAGAGC AGAAAAGTTT A

GGCCTCTCATTCATTCCTTGGGAGACTTTCCTGTATTTATAAAAGACAAGGTA

AGTCAACTTGAAGAGACGTTCGGTCCCTGTGCAAGAAGGTTCTTTAGGGCTCT

GGATCAATTCGACAACATACATGACTTGGTTTTTGTGTTTGGCTGTTACAGGC

ATTGGGGGCACCCATATATAGATTATCGAAAGGGTCTGTCAAAACTATATGA

TCAGGTTCACCTTAAAAAAATGATAGATAAGTCCTACCAGGAGTGCTTAGCA

AGCGACCTAGCCAGGAGGATCCTTAGATGGGGTTTTGATAAGTACTCCAAGT

GGTATCTGGATTCAAGATTCCTAGCCCGAGACCACCCCTTGACTCCTTATATC

AAAACCCAAACATGGCCACCCAAACATATTGTAGACTTGGTGGGGGATACAT

GGCACAAGCTCCCGATCACGCAGATCTTTGAGATTCCTGAATCAATGGATCC

GTCAGAAATATTGGATGACAAATCACATTCTTTCACCAGAACGAGACTAGCT

TCTT GGCTGTC AGAAAACCGAGGGGGGCCTGTTCCT AGCGAAAA AGTT ATT A

TCACGGCCCTGTCTAAGCCGCCTGTCAATCCCCGAGAGTTTCTGAGGTCTATA

GACCTCGGAGGATTGCCAGATGAAGACTTGATAATTGGCCTCAAGCCAAAGG

AACGGGAATTGAAGATTGAAGGTCGATTCTTTGCTCTAATGTCATGGAATCTA

AGATTGTATTTTGTCATCACTGAAAAACTCTTGGCCAACTACATCTTGCCACT

TTTTGACGCGCTGACTATGACAGACAACCTGAACAAGGTGTTTAAAAAGCTG

ATCGACAGGGTCACCGGGCAAGGGCTTTTGGACTATTCAAGGGTCACATATG

C ATTTC ACCTGGACT AT GAAAAGT GGAAC AACC AT C AAAGATT AGAGT C AAC

AGAGGAT GT ATTTTCTGTCCT AGAT C AAGT GTTTGGATT GAAGAGAGTGTTTT

CTAGAACACACGAGTTTTTTCAAAAGGCCTGGATCTATTATTCAGACAGATCA

GACCTCATCGGGTTACGGGAGGATCAAATATACTGCTTAGATGCGTCCAACG

GCCCAACCTGTTGGAATGGCCAGGATGGCGGGCTAGAAGGCTTACGGCAGAA

GGGCTGGAGTCT AGT C AGCTT ATT GAT GAT AGAT AGAGAATCTC AAAT C AGG

AAC AC AAGAACC AAAAT ACT AGCTC A AGGAGAC AACC AGGTTTT ATGTCCGA

CATACATGTTGTCGCCAGGGCTATCTCAAGAGGGGCTCCTCTATGAATTGGAG

AG A AT AT C A AGG A AT GC AC TTTC GAT AT AC AGAGCC GT C GAGGA AGGGGC AT

CTAAGCTAGGGCTGATCATCAAGAAAGAAGAGACCATGTGTAGTTATGACTT

CCTCATCTATGGAAAAACCCCTTTGTTTAGAGGTAACATATTGGTGCCTGAGT CCAAAAGATGGGCCAGAGTCTCTTGCGTCTCTAATGACCAAATAGTCAACCT

CGCCAATATAATGTCGACAGTGTCCACCAATGCGCTAACAGTGGCACAACAC

TCTCAATCTTTGATCAAACCGATGAGGGATTTTCTGCTCATGTCAGTACAGGC

AGTCTTTCACTACCTGCTATTTAGCCCAATCTTAAAGGGAAGAGTTTACAAGA

TTCTGAGCGCTGAAGGGGAGAGCTTTCTCCTAGCCATGTCAAGGATAATCTAT

CTAGATCCTTCTTTGGGAGGGATATCTGGAATGTCCCTCGGAAGATTCCATAT

ACGACAGTTCTCAGACCCTGTCTCTGAAGGGTTATCCTTCTGGAGAGAGATCT

GGTTAAGCTCCCAAGAGTCCTGGATTCACGCGTTGTGTCAAGAGGCTGGAAA

CCCAGATCTTGGAGAGAGAACACTCGAGAGCTTCACTCGCCTTCTAGAAGAT

CCGACCACCTTAAATATCAGAGGAGGGGCCAGTCCTACCATTCTACTCAAGG

AT GC AAT C AGA AAGGCTTT AT ATGACGAGGT GGAC AAGGTGGAAAATTC AGA

GTTTCGAGAGGCAATCCTGTTGTCCAAGACCCATAGAGATAATTTTATACTCT

TCTTAATATCTGTTGAGCCTCTGTTTCCTCGATTTCTCAGTGAGCTATTCAGTT

CGTCTTTTTTGGGAATCCCCGAGTCAATCATTGGATTGATACAAAACTCCCGA

AC GAT A AGA AGGC AGTTT AGA A AGAGT C TC T C A A A A AC TTT AGA AG A AT C CT

TCTACAACTCAGAGATCCACGGGATTAGTCGGATGACCCAGACACCTCAGAG

GGTTGGGGGGGTGT GGCCTT GCTCTTC AGAGAGGGC AGATCT ACTT AGGGAG

ATCTCTTGGGGAAGAAAAGTGGTAGGCACGACAGTTCCTCACCCTTCTGAGA

TGTTGGGATTACTTCCCAAGTCCTCTATTTCTTGCACTTGTGGAGCAACAGGA

GGAGGCAATCCTAGAGTTTCTGTATCAGTACTCCCGTCCTTTGATCAGTCATT

TTTTTCACGAGGCCCCCTAAAGGGATACTTGGGCTCGTCCACCTCTATGTCGA

C C C AGC TATTCCAT GC AT GGG A A A A AGT C AC T AAT GT TC AT GT GGT G A AG AG

AGCTCTATCGTTAAAAGAATCTATAAACTGGTTCATTACTAGAGATTCCAACT

TGGCTCAAGCTCTAATTAGGAACATTATGTCTCTGACAGGCCCTGATTTCCCT

CTAGAGGAGGCCCCTGTCTTCAAAAGGACGGGGTCAGCCTTGCATAGGTTCA

AGTCTGCCAGATACAGCGAAGGAGGGTATTCTTCTGTCTGCCCGAACCTCCTC

TCTCATATTTCTGTTAGTACAGACACCATGTCTGATTTGACCCAAGACGGGAA

GAACTACGATTTCATGTTCCAGCCATTGATGCTTTATGCACAGACATGGACAT

CAGAGCTGGTACAGAGAGACACAAGGCTAAGAGACTCTACGTTTCATTGGCA

CCTCCGATGCAACAGGTGTGTGAGACCCATTGACGACGTGACCCTGGAGACC

TCTCAGATCTTCGAGTTTCCGGATGTGTCGAAAAGAATATCCAGAATGGTTTC

TGGGGCTGTGCCTCACTTCCAGAGGCTTCCCGATATCCGTCTGAGACCAGGAG

ATTTTGAATCTCTAAGCGGTAGAGAAAAGTCTCACCATATCGGATCAGCTCA

GGGGCTCTTATACTCAATCTTAGTGGCAATTCACGACTCAGGATACAATGATG GAACCATCTTCCCTGTCAACATATACGGCAAGGTTTCCCCTAGAGACTATTTG

AGAGGGCTCGCAAGGGGAGTATTGATAGGATCCTCGATTTGCTTCTTGACAA

GAAT GAC AAAT ATC AAT ATT AAT AGACCTCTT GAATT GGTCTC AGGGGT AAT C

TCATATATTCTCCTGAGGCTAGATAACCATCCCTCCTTGTACATAATGCTCAG

AGAACCGTCTCTTAGAGGAGAGATATTTTCTATCCCTCAGAAAATCCCCGCCG

CTTATCCAACCACTATGAAAGAAGGCAACAGATCAATCTTGTGTTATCTCCAA

CAT GT GCT ACGCT AT GAGCGAGAGAT AAT C ACGGCGTCTCC AGAGAAT GACT

GGCTATGGATCTTTTCAGACTTTAGAAGTGCCAAAATGACGTACCTATCCCTC

ATTACTTACCAGTCTCATCTTCTACTCCAGAGGGTTGAGAGAAACCTATCTAA

GAGTATGAGAGATAACCTGCGACAATTGAGTTCTTTGATGAGGCAGGTGCTG

GGC GGGC AC GG AG A AG AT ACC TT AGAGT C AGAC GAC A AC ATT C A AC GACTGC

T AAAAGACTCTTT ACGA AGGAC AAGAT GGGTGGATC A AGAGGT GCGCC ATGC

AGCTAGAACCATGACTGGAGATTACAGCCCCAACAAGAAGGTGTCCCGTAAG

GTAGGATGTTCAGAATGGGTCTGCTCTGCTCAACAGGTTGCAGTCTCTACCTC

AGCAAACCCGGCCCCTGTCTCGGAGCTTGACATAAGGGCCCTCTCTAAGAGG

TTCCAGAACCCTTTGATCTCGGGCTTGAGAGTGGTTCAGTGGGCAACCGGTGC

TCATTATAAGCTTAAGCCTATTCTAGATGATCTCAATGTTTTCCCATCTCTCTG

CCTT GT AGTT GGGGACGGGTC AGGGGGGAT AT C AAGGGC AGTCCTC AAC AT G

TTTCCAGATGCCAAGCTTGTGTTCAACAGTCTTTTAGAGGTGAATGACCTGAT

GGCTTCCGG AAC ACATCCACTGCCTCCTTCAGCAATCATGAGGGGAGG AAAT

GATATCGTCTCCAGAGTGATAGATCTTGACTCAATCTGGGAAAAACCGTCCG

ACTTGAGAAACTTGGCAACCTGGAAATACTTCCAGTCAGTCCAAAAGCAGGT

CAACATGTCCTATGACCTCATTATTTGCGATGCAGAAGTTACTGACATTGCAT

CTATCAACCGGATCACCCTGTTAATGTCCGATTTTGCATTGTCTATAGATGGA

CCACTCTATTTGGTCTTCAAAACTTATGGGACTATGCTAGTAAATCCAAACTA

CAAGGCTATTCAACACCTGTCAAGAGCGTTCCCCTCGGTCACAGGGTTTATCA

CCCAAGTAACTTCGTCTTTTTCATCTGAGCTCTACCTCCGATTCTCCAAACGA

GGGAAGTTTTTCAGAGATGCTGAGTACTTGACCTCTTCCACCCTTCGAGAAAT

GAGCCTTGTGTTATTCAATTGTAGCAGCCCCAAGAGTGAGATGCAGAGAGCT

CGTTCCTTGAACTATCAGGATCTTGTGAGAGGATTTCCTGAAGAAATCATATC

AAATCCTTACAATGAGATGATCATAACTCTGATTGACAGTGATGTAGAATCTT

TTCTAGTCCACAAGATGGTTGATGATCTTGAGTTACAGAGGGGAACTCTGTCT

AAAGTGGCTATCATTATAGCCATCATGATAGTTTTCTCCAACAGAGTCTTCAA

CGTTTCCAAACCCCTAACTGACCCCTCGTTCTATCCACCGTCTGATCCCAAAA TCCTGAGGCACTTCAACATATGTTGCAGTACTATGATGTATCTATCTACTGCT

TTAGGTGACGTCCCTAGCTTCGCAAGACTTCACGACCTGTATAACAGACCTAT

AACTTATTACTTCAGAAAGCAAGTCATTCGAGGGAACGTTTATCTATCTTGGA

GTTGGTCCAACGACACCTCAGTGTTCAAAAGGGTAGCCTGTAATTCTAGCCTG

AGTCTGTCATCTCACTGGATCAGGTTGATTTACAAGATAGTGAAGACTACCAG

ACTCGTTGGCAGCATCAAGGATCTATCCAGAGAAGTGGAAAGACACCTTCAT

AGGTACAACAGGTGGATCACCCTAGAGGATATCAGATCTAGATCATCCCTAC

TAGACTACAGTTGCCTGTGAACCGGATACTCCTGGAAGCCTGCCCATGCTAA

GACTCTTGTGTGATGTATCTTGAAAAAAACAAGATCCTAAATCTGAACCTTTG

GTTGTTTGATTGTTTTTCTCAtttttgttgtttatttgttaagcgt.

In one embodiment, the nucleic acid comprises the sequence of SEQ ID NO: 12, shown below (RABV vector: Coravax V4-China (S1-RABVG-T2A-P)): ACGCTTAACAACCAGATCAAAGAAAAAACAGACATTGTCAATTGCAAAGCAA AAATGTAACACCCCTACAATGGATGCCGACAAGATTGTATTCAAAGTCAATA AT C AGGT GGT C TC TT T G A AGC C T GAG AT T AT C GT GG AT C A AT AT G AGT AC A AG TACCCTGCCATCAAAGATTTGAAAAAGCCCTGTATAACCCTAGGAAAGGCTC CCGATTTAAATAAAGCATACAAGTCAGTTTTGTCAGGCATGAGCGCCGCCAA ACTTAATCCTGACGATGTATGTTCCTATTTGGCAGCGGCAATGCAGTTTTTTG AGGGGACATGTCCGGAAGACTGGACCAGCTATGGAATTGTGATTGCACGAAA AGGAGATAAGATCACCCCAGGTTCTCTGGTGGAGATAAAACGTACTGATGTA GAAGGGAATT GGGCTCTGAC AGGAGGC AT GGAACTGAC AAGAGACCCC ACT GTCCCTGAGCATGCGTCCTTAGTCGGTCTTCTCTTGAGTCTGTATAGGTTGAG CAAAATATCCGGGCAAAACACTGGTAACTATAAGACAAACATTGCAGACAGG ATAGAGCAGATTTTTGAGACAGCCCCTTTTGTTAAAATCGTGGAACACCATAC TC T A AT GAC A AC TC AC A Aa AT GT GT GCT A ATT GGAGT ACT AT AC C A A AC TTC A GATTTTTGGCCGGAACCTATGACATGTTTTTCTCCCGGATTGAGCATCTATATT CAGCAATCAGAGTGGGCACAGTTGTCACTGCTTATGAAGACTGTTCAGGACT GGTATCATTTACTGGGTTCATAAAACAAATCAATCTCACCGCTAGAGAGGCA ATACTATATTTCTTCCACAAGAACTTTGAGGAAGAGATAAGAAGAATGTTTG AGCCAGGGCAGGAGACAGCTGTTCCTCACTCTTATTTCATCCACTTCCGTTCA CTAGGCTTGAGTGGGAAATCTCCTTATTCATCAAATGCTGTTGGTCACGTGTT CAATCTCATTCACTTTGTAGGATGCTATATGGGTCAAGTCAGATCCCTAAATG CAACGGTTATTGCTGCATGTGCTCCTCATGAAATGTCTGTTCTAGGGGGCTAT CTGGGAGAGGAATTCTTCGGGAAAGGGAC ATTTGAAAGAAGATTCTTC AGAG AT GAG A A AG A AC TT C A AG A AT AC G AGGC GGC T G A AC T G AC A A AG AC T G AC G

TAGCACTGGCAGATGATGGAACTGTCAACTCTGACGACGAGGACTACTTTTC

AGGT GAAACC AGAAGTCCGGAGGCTGTTT AT ACTCGAAT CAT GAT GAAT GGA

GGTCGACTAAAGAGATCTCACATACGGAGATATGTCTCAGTCAGTTCCAATC

ATCAAGCCCGTCCAAACTCATTCGCCGAGTTTCTAAACAAGACATATTCGAGT

GACTCATAAcatgaaaaaaactaacacccctcccgtacgGCCACCATGTTCGTGTTTCTGGTGC

TGCTGCCTCTGGTGAGCTCCCAGTGCGTGAACCTGACCACAAGGACCCAGCT

GCCCCCTGCCTATACCAATTCCTTCACACGGGGCGTGTACTATCCCGACAAGG

TGTTCCGGAGCAGCGTGCTGCACTCCACACAGGATCTGTTTCTGCCTTTCTTTT

CTAACGTGACCTGGTTCCACGCCATCCACGTGAGCGGCACCAATGGCACAAA

GCGGTTCGACAATCCAGTGCTGCCCTTTAACGATGGCGTGTACTTCGCCTCCA

CCGAGAAGTCTAACATCATCAGAGGCTGGATCTTTGGCACCACACTGGACAG

CAAGACACAGTCCCTGCTGATCGTGAACAATGCCACCAACGTGGTCATCAAG

GTGTGCGAGTTCCAGTTTTGTAATGATCCATTCCTGGGCGTGTACTATCACAA

GAACAATAAGTCTTGGATGGAGAGCGAGTTTCGCGTGTATTCCTCTGCCAAC

AATTGCACATTTGAGTACGTGTCCCAGCCCTTCCTGATGGACCTGGAGGGCAA

GC AGGGC AATTT C AAGAACCTGAGGGAGTTCGT GTTT AAGAAT ATCGAT GGC

TACTTCAAAATCTACTCCAAGCACACCCCAATCAACCTGGTGCGCGACCTGCC

ACAGGGCTTCTCTGCCCTGGAGCCACTGGTGGATCTGCCCATCGGCATCAACA

TCACCCGGTTTCAGACACTGCTGGCCCTGCACAGAAGCTACCTGACACCAGG

CGACAGCTCCTCTGGATGGACCGCAGGAGCAGCAGCCTACTATGTGGGCTAT

CTGCAGCCCAGGACCTTCCTGCTGAAGTACAACGAGAATGGCACCATCACAG

ACGCCGTGGATTGCGCCCTGGATCCCCTGTCTGAGACCAAGTGTACACTGAA

GAGCTTTACCGTGGAGAAGGGCATCTATCAGACAAGCAATTTCAGGGTGCAG

CCTACCGAGTCCATCGTGCGCTTTCCCAATATCACAAACCTGTGCCCTTTTGG

CGAGGTGTTCAACGCAACCCGCTTCGCCAGCGTGTACGCCTGGAATAGGAAG

CGCATCTCCAACTGCGTGGCCGACTATTCTGTGCTGTACAACAGCGCCTCCTT

CTCTACCTTTAAGTGCTATGGCGTGAGCCCCACAAAGCTGAATGACCTGTGCT

TTACCAACGTGTACGCCGATTCCTTCGTGATCAGGGGCGACGAGGTGCGCCA

GATCGCACCAGGACAGACAGGCAAGATCGCAGACTACAATTATAAGCTGCCT

GACGATTTCACCGGCTGCGTGATCGCCTGGAACTCTAACAATCTGGATAGCA

AAGTGGGCGGCAACTACAATTATCTGTACCGGCTGTTTAGAAAGTCTAATCTG

AAGCCATTCGAGAGGGACATCTCCACAGAAATCTACCAGGCCGGCTCTACCC

CCTGCAATGGCGTGGAGGGCTTTAACTGTTATTTCCCTCTGCAGAGCTACGGC TTCCAGCCAACAAACGGCGTGGGCTATCAGCCCTACCGCGTGGTGGTGCTGT

CTTTTGAGCTGCTGCACGCACCTGCAACAGTGTGCGGACCAAAGAAGAGCAC

CAATCTGGTGAAGAACAAGTGCGTGAACTTCAACTTCAACGGACTGACCGGA

ACAGGCGTGCTGACCGAGTCCAACAAGAAGTTCCTGCCTTTTCAGCAGTTCG

GCAGGGACATCGCAGATACCACAGACGCCGTGCGCGACCCTCAGACCCTGGA

GATCCTGGACATCACACCATGCTCCTTCGGCGGCGTGTCTGTGATCACACCAG

GC AC C A AT AC A AGC A AC C AGGT GGCC GT GC T GT AT C AGGAC GT GA ATT GT AC

CGAGGTGCCAGTGGCAATCCACGCAGATCAGCTGACCCCTACATGGCGGGTG

TACTCTACCGGCAGCAACGTGTTCCAGACAAGAGCCGGATGCCTGATCGGAG

CAGAGCACGTGAACAATAGCTATGAGTGCGACATCCCTATCGGCGCCGGCAT

CTGTGCCTCCTACCAGACCCAGACAAACTCCCCAAGGTCTGTGGGAGATGAG

GCCGAAGACTTTGTGGAAGTCCACCTGCCTGATGTGCATAACCAGGTGTCTG

GCGTCGACCTGGGACTGCCAAATTGGGGCAAGTACGTGCTGCTGAGTGCTGG

AGCACTGACTGCCCTGATGCTGATCATTTTCCTGATGACCTGCTGTCGGCGCG

TGAAC AGAAGT GAGCCC ACTC AGC AC AATCTGCGAGGAACCGGGAGAGAAG

TGTCAGTCACACCTCAGAGCGGGAAAATCATTAGTAGTTGGGAATCACATAA

AAGCGGGGGCGAGACCAGGCTGggatccggctccggcgagggcaggggaagtctactaacatgcgggg acgtggaggaaaatcccggccccATGAGCAAGATCTTTGTCAATCCTAGTGCTATTAGAGC

CGGTCTGGCCGATCTTGAGATGGCTGAAGAAACTGTTGATCTGATCAATAGA

A AT AT C GA AG AC A AT C AGGC TC AT C TCC A AGGGGA ACC C AT AG AGGT GGAC A

ATCTCCCTGAGGATATGGGGCGACTTCACCTGGATGATGGAAAATCGCCCAA

CC ATGGTGAGAT AGCC AAGGT GGGAGAAGGC AAGT ATCGAGAGGACTTTC A

GATGGATGAAGGAGAGGATCCTAGCTTCCTGTTCCAGTCATACCTGGAAAAT

GTTGGAGTCC AAAT AGTC AGAC AAAT GAGGT C AGGAGAGAGATTTCTC AAGA

TATGGTCACAGACCGTAGAAGAGATTATATCCTATGTCGCGGTCAACTTTCCC

AACCCTCCAGGAAAGTCTTCAGAGGATAAATCAACCCAGACTACTGGCCGAG

AGCTCAAGAAGGAGACAACACCCACTCCTTCTCAGAGAGAAAGCCAATCATC

GAAAGCCAGGATGGCGGCTCAAATTGCTTCTGGCCCTCCAGCCCTTGAATGG

TCGGCT ACC AATGAAGAGGAT GATCT ATC AGT GGAGGCTGAGATCGCTC ACC

AGATTGCAGAAAGTTTCTCCAAAAAATATAAGTTTCCCTCTCGATCCTCAGGG

ATACTCTTGTATAATTTTGAGCAATTGAAAATGAACCTTGATGATATAGTTAA

AGAGGC AAAAAAT GT ACC AGGTGTGACCCGTTT AGCCC AT GACGGGTCC AAA

CTCCCCCTAAGATGTGTACTGGGATGGGTCGCTTTGGCCAACTCTAAGAAATT

CCAGTTGTTAGTCGAATCCGACAAGCTGAGTAAAATCATGCAAGATGACTTG AATCGCTATACATCTTGCTAACCGAACCTCTCCCCTCAGTCCCTCTAGACAAT

AAAATCCGAGATGTCCCAAAGTCAACATGAAAAAAACAGGCAACACCACTG

ATAAAATGAACCTCCTACGTAAGATAGTGAAAAACCGCAGGGACGAGGACA

CTCAAAAATCCTCTCCCGCGTCAGCCCCTCTGGATGACGATGACTTGTGGCTT

CCACCCCCTGAATACGTCCCGCTGAAAGAACTTACAGGCAAGAAGAACATGA

GGAACTTTTGTATCAACGGAAGGGTTAAAGTGTGTAGCCCGAATGGTTACTC

GTTCAGGATCCTGCGGCACATTCTGAAATCATTCGACGAGATATATTCTGGGA

ATCATAGGATGATCGGGTTAGTCAAAGTGGTTATTGGACTGGCTTTGTCAGGA

TCTCCAGTCCCTGAGGGCCTGAACTGGGTATACAAATTGAGGAGAACCTTTAT

CTTCCAGTGGGCTGATTCCAGGGGCCCTCTTGAAGGGGAGGAGTTGGAATAC

TCTCAGGAGATCACTTGGGATGATGATACTGAGTTCGTCGGATTGCAAATAA

GAGTGATTGCAAAACAGTGTCATATCCAGGGCAGAGTCTGGTGTATCAACAT

GAACCCGAGAGCATGTCAACTATGGTCTGACATGTCTCTTCAGACACAAAGG

TCCGAAGAGGACAAAGATTCCTCTCTGCTTCTAGAATAATCAGATTATATCCC

GCAAATTTATCACTTGTTTACCTCTGGAGGAGAGAACATATGGGCTCAACTCC

AACCCTTGGGAGCAATATAACAAAAAACATGTTATGGTGCCATTAAACCGCT

GCATTTCATCAAAGTCAAGTTGATTACCTTTACATTTTGATCCTCTTGGATGTG

AAAAAA ACT ATT AAC ATCCCTC AAAAGACCccggg A AAGAT GGTTCCTC AGGCT

CTCCTGTTTGTACCCCTTCTGGTTTTTCCATTGTGTTTTGGGAAATTCCCTATTT

AC AC GAT ACC AG AC A AGC TT GGT C CC T GGAGTCC GATT GAC AT AC AT C AC CT

CAGCTGCCCAAACAATTTGGTAGTGGAGGACGAAGGATGCACCAACCTGTCA

GGGTTCTCCTACATGGAACTTAAAGTTGGATACATCTTAGCCATAAAAGTGA

ACGGGTTCACTTGCACAGGCGTTGTGACGGAGGCTGAAACCTACACTAACTT

CGTTGGTTATGTCACAACCACGTTCAAAAGAAAGCATTTCCGCCCAACACCA

GATGCATGTAGAGCCGCGTACAACTGGAAGATGGCCGGTGACCCCAGATATG

AAGAGTCTCTACACAATCCGTACCCTGACTACCGCTGGCTTCGAACTGTAAAA

ACCACCAAGGAGTCTCTCGTTATCATATCTCCAAGTGTGGCAGATTTGGACCC

ATATGACAGATCCCTTCACTCGAGGGTCTTCCCTAGCGGGAAGTGCTCAGGA

GTAGCGGTGTCTTCTACCTACTGCTCCACTAACCACGATTACACCATTTGGAT

GCCCGAGAATCCGAGACTAGGGATGTCTTGTGACATTTTTACCAATAGTAGA

GGGAAGAGAGC ATCC AAAGGGAGT GAGACTT GCGGCTTTGT AGAT GAAAGA

GGCCTATATAAGTCTTTAAAAGGAGCATGCAAACTCAAGTTATGTGGAGTTCT

AGGACTT AGACTT AT GGATGGAAC AT GGGTCTCGAT GC AAAC ATC AAAT GAA

ACCAAATGGTGCCCTCCCGATAAGTTGGTGAACCTGCACGACTTTCGCTCAGA CGAAATTGAGCACCTTGTTGTAGAGGAGTTGGTCAGGAAGAGAGAGGAGTGT

CTGGATGCACTAGAGTCCATCATGACAACCAAGTCAGTGAGTTTCAGACGTC

TCAGTCATTTAAGAAAACTTGTCCCTGGGTTTGGAAAAGCATATACCATATTC

AACAAGACCTTGATGGAAGCCGATGCTCACTACAAGTCAGTCgagACTTGGAA

TGAGATCCTCCCTTCAAAAGGGTGTTTAAGAGTTGGGGGGAGGTGTCATCCTC

ATGTGAACGGGGTGTTTTTCAATGGTATAATATTAGGACCTGACGGCAATGTC

TTAATCCCAGAGATGCAATCATCCCTCCTCCAGCAACATATGGAGTTGTTGGA

ATCCTCGGTTATCCCCCTTGTGCACCCCCTGGCAGACCCGTCTACCGTTTTCA

AGGACGGTGACGAGGCTGAGGATTTTGTTGAAGTTCACCTTCCCGATGTGCA

CAATCAGGTCTCAGGAGTTGACTTGGGTCTCCCGAACTGGGGGAAGTATGTA

TTACTGAGTGCAGGGGCCCTGACTGCCTTGATGTTGATAATTTTCCTGATGAC

AT GTT GT AGAAGAGT C AATCGAT C AGAACCT ACGC AAC AC AATCTC AGAGGG

AC AGGGAGGGAGGT GT C AGTC ACTCCCC AAAGCGGGAAGATC AT ATCTTC AT

GGGAATCACACAAGAGTGGGGGTGAGACCAGACTGTAAttaattaaCGTCCTTTCA

AC GAT C C A AGTCcatgaaaaaaactaacacccctcccgtacctagcTT AT A A AGT GC T GGGT CAT

CT AAGCTTTT C AGTCGAGAAA AAAAC ATT AGATC AGAAGAAC AACTGGC AAC

ACTTCTCAACCTGAGACTTACTTCAAGATGCTCGATCCTGGAGAGGTCTATGA

TGACCCTATTGACCCAATCGAGTTAGAGGCTGAACCCAGAGGAACCCCCATT

GTCCCCAACATCTTGAGGAACTCTGACTACAATCTCAACTCTCCTTTGATAGA

AGATCCTGCTAGACTAATGTTAGAATGGTTAAAAACAGGGAATAGACCTTAT

CGGATGACTCTAACAGACAATTGCTCCAGGTCTTTCAGAGTTTTGAAAGATTA

TTTCAAGAAGGTAGATTTGGGTTCTCTCAAGGTGGGCGGAATGGCTGCACAG

TCAATGATTTCTCTCTGGTTATATGGTGCCCACTCTGAATCCAACAGGAGCCG

GAGATGTATAACAGACTTGGCCCATTTCTATTCCAAGTCGTCCCCCATAGAGA

AGCTGTTGAATCTCACGCTAGGAAATAGAGGGCTGAGAATCCCCCC AGAGGG

AGT GTT A AGTT GCC TT GAGAGGGTTG ATT AT GAT A AT GC ATTTGGA AGGT AT C

TTGCCAACACGTATTCCTCTTACTTGTTCTTCCATGTAATCACCTTATACATGA

ACGCCCTAGACTGGGATGAAGAAAAGACCATCCTAGCATTATGGAAAGATTT

A AC CTC AGT GGAC ATCGGGA AGGAC TT GGT A A AGTTC A A AGAC C A A AT AT GG

GGACTGCTGATCGTGACAAAGGACTTTGTTTACTCCCAAAGTTCCAATTGTCT

TTTTGACAGAAACTACACACTTATGCTAAAAGATCTTTTCTTGTCTCGCTTCA

ACTCCTTAATGGTCTTGCTCTCTCCCCCAGAGCCCCGATACTCAGATGACTTG

ATATCTCAACTATGCCAGCTGTACATTGCTGGGGATCAAGTCTTGTCTATGTG

TGGAAACTCCGGCTATGAAGTCATCAAAATATTGGAGCCATATGTCGTGAAT AGTTTAGTCCAGAGAGCAGAAAAGTTTAGGCCTCTCATTCATTCCTTGGGAGA

CTTTCCTGTATTTATAAAAGACAAGGTAAGTCAACTTGAAGAGACGTTCGGTC

CCTGTGCAAGAAGGTTCTTTAGGGCTCTGGATCAATTCGACAACATACATGAC

TTGGTTTTTGTGTTTGGCTGTTACAGGCATTGGGGGCACCCATATATAGATTA

TCGAAAGGGTCTGTCAAAACTATATGATCAGGTTCACCTTAAAAAAATGATA

GATAAGTCCTACCAGGAGTGCTTAGCAAGCGACCTAGCCAGGAGGATCCTTA

GAT GGGGTTTT GAT AAGT ACTCC AAGT GGT ATCTGGATT C A AGATTCCT AGCC

CGAGACCACCCCTTGACTCCTTATATCAAAACCCAAACATGGCCACCCAAAC

AT ATT GT AGACTTGGT GGGGGAT AC ATGGC AC AAGCTCCCGAT C ACGC AGAT

CTTTGAGATTCCTGAATCAATGGATCCGTCAGAAATATTGGATGACAAATCAC

ATTCTTTCACCAGAACGAGACTAGCTTCTTGGCTGTCAGAAAACCGAGGGGG

GCCTGTTCCTAGCGAAAAAGTTATTATCACGGCCCTGTCTAAGCCGCCTGTCA

ATCCCCGAGAGTTTCTGAGGTCT AT AGACCTCGGAGGATT GCC AGATGAAGA

CTTGATAATTGGCCTCAAGCCAAAGGAACGGGAATTGAAGATTGAAGGTCGA

TTCTTTGCTCTAATGTCATGGAATCTAAGATTGTATTTTGTCATCACTGAAAAA

CTCTTGGCCAACTACATCTTGCCACTTTTTGACGCGCTGACTATGACAGACAA

CCTGAACAAGGTGTTTAAAAAGCTGATCGACAGGGTCACCGGGCAAGGGCTT

TTGGACTATTCAAGGGTCACATATGCATTTCACCTGGACTATGAAAAGTGGA

ACAACCATCAAAGATTAGAGTCAACAGAGGATGTATTTTCTGTCCTAGATCA

AGT GTTTGGATT GAAGAGAGT GTTTTCT AGAAC AC ACGAGTTTTTT C AAAAGG

CCTGGATCTATTATTCAGACAGATCAGACCTCATCGGGTTACGGGAGGATCA

AATATACTGCTTAGATGCGTCCAACGGCCCAACCTGTTGGAATGGCCAGGAT

GGCGGGCTAGAAGGCTTACGGCAGAAGGGCTGGAGTCTAGTCAGCTTATTGA

T GAT AGAT AGAGAATCTC AA ATC AGGAAC AC AAGAACC AAAAT ACT AGCTC A

AGGAGACAACCAGGTTTTATGTCCGACATACATGTTGTCGCCAGGGCTATCTC

AAGAGGGGCTCCTCTATGAATTGGAGAGAATATCAAGGAATGCACTTTCGAT

AT AC AG AGC C GT C G AGG A AGGGGC AT C T A AGC T AGGGC T GAT CATC A AG A A

AGAAGAGACCATGTGTAGTTATGACTTCCTCATCTATGGAAAAACCCCTTTGT

TT AGAGGT AAC AT ATT GGT GCCTGAGTCC AAAAGAT GGGCC AGAGTCTCTTG

CGTCTCTAATGACCAAATAGTCAACCTCGCCAATATAATGTCGACAGTGTCCA

CCAATGCGCTAACAGTGGCACAACACTCTCAATCTTTGATCAAACCGATGAG

GGATTTTCTGCTCATGTCAGTACAGGCAGTCTTTCACTACCTGCTATTTAGCCC

AATCTT AAAGGGA AGAGTTT AC AAGATTCTGAGCGCTGAAGGGGAGAGCTTT

CTCCTAGCCATGTCAAGGATAATCTATCTAGATCCTTCTTTGGGAGGGATATC TGGAATGTCCCTCGGAAGATTCCATATACGACAGTTCTCAGACCCTGTCTCTG

AAGGGTTATCCTTCTGGAGAGAGATCTGGTTAAGCTCCCAAGAGTCCTGGATT

C ACGCGTTGT GT C AAGAGGCTGGAAACCC AGATCTTGGAGAGAGAAC ACTCG

AGAGCTTCACTCGCCTTCTAGAAGATCCGACCACCTTAAATATCAGAGGAGG

GGCCAGTCCTACCATTCTACTCAAGGATGCAATCAGAAAGGCTTTATATGAC

GAGGT GGAC AAGGTGGA AAATT C AGAGTTTCGAGAGGC AATCCTGTT GTCC A

AGACCCATAGAGATAATTTTATACTCTTCTTAATATCTGTTGAGCCTCTGTTTC

CTCGATTTCTCAGTGAGCTATTCAGTTCGTCTTTTTTGGGAATCCCCGAGTCAA

TCATTGGATTGATACAAAACTCCCGAACGATAAGAAGGCAGTTTAGAAAGAG

TCTCTCAAAAACTTTAGAAGAATCCTTCTACAACTCAGAGATCCACGGGATTA

GTCGGATGACCCAGACACCTCAGAGGGTTGGGGGGGTGTGGCCTTGCTCTTC

AGAGAGGGC AGATCT ACTT AGGGAGATCTCTT GGGGAAGAAAAGT GGT AGG

CACGACAGTTCCTCACCCTTCTGAGATGTTGGGATTACTTCCCAAGTCCTCTA

TTTCTTGCACTTGTGGAGCAACAGGAGGAGGCAATCCTAGAGTTTCTGTATCA

GTACTCCCGTCCTTTGATCAGTCATTTTTTTCACGAGGCCCCCTAAAGGGATA

CTTGGGCTCGTCCACCTCTATGTCGACCCAGCTATTCCATGCATGGGAAAAAG

T C ACT A AT GTT CAT GT GGT GA AGAGAGCTCT AT C GTT A A A AGA ATCT AT A A AC

TGGTTCATTACTAGAGATTCCAACTTGGCTCAAGCTCTAATTAGGAACATTAT

GTCTCTGACAGGCCCTGATTTCCCTCTAGAGGAGGCCCCTGTCTTCAAAAGGA

CGGGGTCAGCCTTGCATAGGTTCAAGTCTGCCAGATACAGCGAAGGAGGGTA

TTCTTCTGTCTGCCCGAACCTCCTCTCTCATATTTCTGTTAGTACAGACACCAT

GTCTGATTTGACCCAAGACGGGAAGAACTACGATTTCATGTTCCAGCCATTGA

TGCTTTATGCACAGACATGGACATCAGAGCTGGTACAGAGAGACACAAGGCT

AAGAGACTCTACGTTTCATTGGCACCTCCGATGCAACAGGTGTGTGAGACCC

ATTGACGACGTGACCCTGGAGACCTCTCAGATCTTCGAGTTTCCGGATGTGTC

GAAAAGAATATCCAGAATGGTTTCTGGGGCTGTGCCTCACTTCCAGAGGCTTC

CCGATATCCGTCTGAGACCAGGAGATTTTGAATCTCTAAGCGGTAGAGAAAA

GTCTCACCATATCGGATCAGCTCAGGGGCTCTTATACTCAATCTTAGTGGCAA

TTCACGACTCAGGATACAATGATGGAACCATCTTCCCTGTCAACATATACGGC

AAGGTTTCCCCT AGAGACT ATTT GAGAGGGCTCGC AAGGGGAGT ATT GAT AG

GATCCTCGATTTGCTTCTTGACAAGAATGACAAATATCAATATTAATAGACCT

CTTGAATTGGTCTCAGGGGTAATCTCATATATTCTCCTGAGGCTAGATAACCA

TCCCTCCTTGTACATAATGCTCAGAGAACCGTCTCTTAGAGGAGAGATATTTT

CTATCCCTCAGAAAATCCCCGCCGCTTATCCAACCACTATGAAAGAAGGCAA CAGATCAATCTTGTGTTATCTCCAACATGTGCTACGCTATGAGCGAGAGATAA

TCACGGCGTCTCCAGAGAATGACTGGCTATGGATCTTTTCAGACTTTAGAAGT

GCCAAAATGACGTACCTATCCCTCATTACTTACCAGTCTCATCTTCTACTCCA

GAGGGTTGAGAGAAACCTATCTAAGAGTATGAGAGATAACCTGCGACAATTG

AGTTCTTTGATGAGGCAGGTGCTGGGCGGGCACGGAGAAGATACCTTAGAGT

CAGACGACAACATTCAACGACTGCTAAAAGACTCTTTACGAAGGACAAGATG

GGT GGATC AAGAGGT GCGCC ATGC AGCT AGAACC AT GACTGGAGATT AC AGC

CCCAACAAGAAGGTGTCCCGTAAGGTAGGATGTTCAGAATGGGTCTGCTCTG

CTCAACAGGTTGCAGTCTCTACCTCAGCAAACCCGGCCCCTGTCTCGGAGCTT

GACATAAGGGCCCTCTCTAAGAGGTTCCAGAACCCTTTGATCTCGGGCTTGAG

AGTGGTTCAGTGGGCAACCGGTGCTCATTATAAGCTTAAGCCTATTCTAGATG

ATCTCAATGTTTTCCCATCTCTCTGCCTTGTAGTTGGGGACGGGTCAGGGGGG

ATATCAAGGGCAGTCCTCAACATGTTTCCAGATGCCAAGCTTGTGTTCAACAG

TCTTTTAGAGGTGAATGACCTGATGGCTTCCGGAACACATCCACTGCCTCCTT

CAGCAATCATGAGGGGAGGAAATGATATCGTCTCCAGAGTGATAGATCTTGA

CTCAATCTGGGAAAAACCGTCCGACTTGAGAAACTTGGCAACCTGGAAATAC

TTCCAGTCAGTCCAAAAGCAGGTCAACATGTCCTATGACCTCATTATTTGCGA

TGCAGAAGTTACTGACATTGCATCTATCAACCGGATCACCCTGTTAATGTCCG

ATTTTGCATTGTCTATAGATGGACCACTCTATTTGGTCTTCAAAACTTATGGG

ACTATGCTAGTAAATCCAAACTACAAGGCTATTCAACACCTGTCAAGAGCGT

TCCCCTCGGTCACAGGGTTTATCACCCAAGTAACTTCGTCTTTTTCATCTGAGC

TCTACCTCCGATTCTCCAAACGAGGGAAGTTTTTCAGAGATGCTGAGTACTTG

ACCTCTTCCACCCTTCGAGAAATGAGCCTTGTGTTATTCAATTGTAGCAGCCC

CAAGAGTGAGATGCAGAGAGCTCGTTCCTTGAACTATCAGGATCTTGTGAGA

GGATTTCCTGAAGAAATCATATCAAATCCTTACAATGAGATGATCATAACTCT

GATTGAC AGT GATGT AGAATCTTTTCT AGTCC AC AAGAT GGTT GAT GATCTT G

AGTTACAGAGGGGAACTCTGTCTAAAGTGGCTATCATTATAGCCATCATGAT

AGTTTTCTCCAACAGAGTCTTCAACGTTTCCAAACCCCTAACTGACCCCTCGT

TCTATCCACCGTCTGATCCCAAAATCCTGAGGCACTTCAACATATGTTGCAGT

ACTATGATGTATCTATCTACTGCTTTAGGTGACGTCCCTAGCTTCGCAAGACT

TCACGACCTGTATAACAGACCTATAACTTATTACTTCAGAAAGCAAGTCATTC

GAGGGA AC GTTT AT C T ATCTTGGAGTT GGT C C A AC GAC AC CTC AGT GTT C A A A

AGGGTAGCCTGTAATTCTAGCCTGAGTCTGTCATCTCACTGGATCAGGTTGAT

TTAC AAGAT AGTGAAGACTACCAGACTCGTTGGCAGCATCAAGGATCTATCC AGAGAAGTGGAAAGACACCTTCATAGGTACAACAGGTGGATCACCCTAGAG

GATATCAGATCTAGATCATCCCTACTAGACTACAGTTGCCTGTGAACCGGATA

CTCCTGGAAGCCTGCCCATGCTAAGACTCTTGTGTGATGTATCTTGAAAAAAA

CAAGATCCTAAATCTGAACCTTTGGTTGTTTGATTGTTTTTCTCAtttttgttgtttatttgtt aagcgt

In one embodiment, the nucleic acid comprises the sequence of SEQ ID NO: 13, shown below (RABV vector: Coravax V4 South Africa):

ACGCTTAACAACCAGATCAAAGAAAAAACAGACATTGTCAATTGCAAAGCAA

AAATGTAACACCCCTACAATGGATGCCGACAAGATTGTATTCAAAGTCAATA

AT C AGGT GGT C TC TT T G A AGC C T GAG AT T AT C GT GG AT C A AT AT G AGT AC A AG

TACCCTGCCATCAAAGATTTGAAAAAGCCCTGTATAACCCTAGGAAAGGCTC

CCGATTTAAATAAAGCATACAAGTCAGTTTTGTCAGGCATGAGCGCCGCCAA

ACTTAATCCTGACGATGTATGTTCCTATTTGGCAGCGGCAATGCAGTTTTTTG

AGGGGACATGTCCGGAAGACTGGACCAGCTATGGAATTGTGATTGCACGAAA

AGGAGATAAGATCACCCCAGGTTCTCTGGTGGAGATAAAACGTACTGATGTA

GAAGGGAATT GGGCTCTGAC AGGAGGC AT GGAACTGAC AAGAGACCCC ACT

GTCCCTGAGCATGCGTCCTTAGTCGGTCTTCTCTTGAGTCTGTATAGGTTGAG

CAAAATATCCGGGCAAAACACTGGTAACTATAAGACAAACATTGCAGACAGG

ATAGAGCAGATTTTTGAGACAGCCCCTTTTGTTAAAATCGTGGAACACCATAC

TC T A AT GAC A AC TC AC A Aa AT GT GT GCT A ATT GGAGT ACT AT AC C A A AC TTC A

GATTTTTGGCCGGAACCTATGACATGTTTTTCTCCCGGATTGAGCATCTATATT

CAGCAATCAGAGTGGGCACAGTTGTCACTGCTTATGAAGACTGTTCAGGACT

GGTATCATTTACTGGGTTCATAAAACAAATCAATCTCACCGCTAGAGAGGCA

ATACTATATTTCTTCCACAAGAACTTTGAGGAAGAGATAAGAAGAATGTTTG

AGCCAGGGCAGGAGACAGCTGTTCCTCACTCTTATTTCATCCACTTCCGTTCA

CTAGGCTTGAGTGGGAAATCTCCTTATTCATCAAATGCTGTTGGTCACGTGTT

CAATCTCATTCACTTTGTAGGATGCTATATGGGTCAAGTCAGATCCCTAAATG

CAACGGTTATTGCTGCATGTGCTCCTCATGAAATGTCTGTTCTAGGGGGCTAT

CTGGGAGAGGAATTCTTCGGGAAAGGGAC ATTTGAAAGAAGATTCTTC AGAG

AT GAG A A AG A AC TT C A AG A AT AC G AGGC GGC T G A AC T GAC A A AG AC T GAC G

TAGCACTGGCAGATGATGGAACTGTCAACTCTGACGACGAGGACTACTTTTC

AGGT GAAACC AGAAGTCCGGAGGCTGTTT AT ACTCGAAT CAT GAT GAAT GGA

GGTCGACTAAAGAGATCTCACATACGGAGATATGTCTCAGTCAGTTCCAATC

ATCAAGCCCGTCCAAACTCATTCGCCGAGTTTCTAAACAAGACATATTCGAGT GACTCATAAcatgaaaaaaactaacacccctcccgtacgGCCACCATGTTCGTGTTTCTGGTGC

TGCTGCCTCTGGTGAGCTCCCAGTGCGTGAACTTCACCACAAGGACCCAGCTG

CCCCCTGCCTATACCAATTCCTTCACACGGGGCGTGTACTATCCCGACAAGGT

GTTCCGGAGCAGCGTGCTGCACTCCACACAGGATCTGTTTCTGCCTTTCTTTTC

TAACGTGACCTGGTTCCACGCCATCCACGTGAGCGGCACCAATGGCACAAAG

CGGTTCGCCAATCCAGTGCTGCCCTTTAACGATGGCGTGTACTTCGCCTCCAC

CGAGAAGTCTAACATCATCAGAGGCTGGATCTTTGGCACCACACTGGACAGC

AAGACACAGTCCCTGCTGATCGTGAACAATGCCACCAACGTGGTCATCAAGG

TGTGCGAGTTCCAGTTTTGTAATGATCCATTCCTGGGCGTGTACTATCACAAG

AACAATAAGTCTTGGATGGAGAGCGAGTTTCGCGTGTATTCCTCTGCCAACA

ATTGCACATTTGAGTACGTGTCCCAGCCCTTCCTGATGGACCTGGAGGGCAAG

C AGGGC AATTT C AAGAACCTGAGGGAGTTCGT GTTT AAGAAT ATCGATGGCT

ACTTCAAAATCTACTCCAAGCACACCCCAATCAACCTGGTGCGCGGCCTGCC

ACAGGGCTTCTCTGCCCTGGAGCCACTGGTGGATCTGCCCATCGGCATCAACA

TCACCCGGTTTCAGACACTGCTGGCCCTGCACAGAAGCTACCTGACACCAGG

CGACAGCTCCTCTGGATGGACCGCAGGAGCAGCAGCCTACTATGTGGGCTAT

CTGCAGCCCAGGACCTTCCTGCTGAAGTACAACGAGAATGGCACCATCACAG

ACGCCGTGGATTGCGCCCTGGATCCCCTGTCTGAGACCAAGTGTACACTGAA

GAGCTTTACCGTGGAGAAGGGCATCTATCAGACAAGCAATTTCAGGGTGCAG

CCTACCGAGTCCATCGTGCGCTTTCCCAATATCACAAACCTGTGCCCTTTTGG

CGAGGTGTTCAACGCAACCCGCTTCGCCAGCGTGTACGCCTGGAATAGGAAG

CGCATCTCCAACTGCGTGGCCGACTATTCTGTGCTGTACAACAGCGCCTCCTT

CTCTACCTTTAAGTGCTATGGCGTGAGCCCCACAAAGCTGAATGACCTGTGCT

TTACCAACGTGTACGCCGATTCCTTCGTGATCAGGGGCGACGAGGTGCGCCA

GATCGC ACC AGGAC AGAC AGGC AAT ATCGC AGACT AC AATT AT AAGCTGCCT

GACGATTTCACCGGCTGCGTGATCGCCTGGAACTCTAACAATCTGGATAGCA

AAGTGGGCGGCAACTACAATTATCTGTACCGGCTGTTTAGAAAGTCTAATCTG

AAGCCATTCGAGAGGGACATCTCCACAGAAATCTACCAGGCCGGCTCTACCC

CCTGCAATGGCGTGAAGGGCTTTAACTGTTATTTCCCTCTGCAGAGCTACGGC

TTCCAGCCAACATATGGCGTGGGCTATCAGCCCTACCGCGTGGTGGTGCTGTC

TTTTGAGCTGCTGCACGCACCTGCAACAGTGTGCGGACCAAAGAAGAGCACC

A ATCTGGT GA AGA AC A AGT GCGT GA AC TT C A AC TT C A AC GGACTGACC GGA A

CAGGCGTGCTGACCGAGTCCAACAAGAAGTTCCTGCCTTTTCAGCAGTTCGGC

AGGGACATCGCAGATACCACAGACGCCGTGCGCGACCCTCAGACCCTGGAGA TCCTGGACATCACACCATGCTCCTTCGGCGGCGTGTCTGTGATCACACCAGGC

ACCAATACAAGCAACCAGGTGGCCGTGCTGTATCAGGGCGTGAATTGTACCG

AGGTGCCAGTGGCAATCCACGCAGATCAGCTGACCCCTACATGGCGGGTGTA

CTCTACCGGCAGCAACGTGTTCCAGACAAGAGCCGGATGCCTGATCGGAGCA

GAGCACGTGAACAATAGCTATGAGTGCGACATCCCTATCGGCGCCGGCATCT

GTGCCTCCTACCAGACCCAGACAAACTCCCCAGAATCAAGCGTGATTCCTCTG

GTCCATCCACTGGCAGATCCCTCCACAGTGTTCAAAGACGGAGATGAGGCCG

AAGACTTTGTGGAAGTCCACCTGCCTGATGTGCATAACCAGGTGTCTGGCGTC

GACCTGGGACTGCC AAATT GGGGC AAGT ACGT GCTGCTGAGT GCTGGAGC AC

TGACTGCCCTGATGCTGATCATTTTCCTGATGACCTGCTGTCGGCGCGTGAAC

AG AAGT G AGC C C AC TC AGC AC A AT C T GC G AGG A AC C GGG AG AG A AGT GT C A

GT C AC AC CTC AGAGC GGGA A A AT C ATT AGT AGTT GGGA AT C AC AT A A A AGCG

GGGGCGAGACCAGGCTGggatccggctccggcgagggcaggggaagtctactaacatgcggggacgtggag gaaaatcccggccccATGAGCAAGATCTTTGTCAATCCTAGTGCTATTAGAGCCGGTC

TGGCCGATCTTGAGATGGCTGAAGAAACTGTTGATCTGATCAATAGAAATAT

CGAAGACAATCAGGCTCATCTCCAAGGGGAACCCATAGAGGTGGACAATCTC

CCTGAGGATATGGGGCGACTTCACCTGGATGATGGAAAATCGCCCAACCATG

GT GAG AT AGCC A AGGT GGGAG A AGGC A AGT AT C GAGAGGACTTT C AGAT GG

ATGAAGGAGAGGATCCTAGCTTCCTGTTCCAGTCATACCTGGAAAATGTTGG

AGTCC AA AT AGT C AGAC AAAT GAGGT C AGGAGAGAGATTTCTC AAGAT AT GG

TCACAGACCGTAGAAGAGATTATATCCTATGTCGCGGTCAACTTTCCCAACCC

TCCAGGAAAGTCTTCAGAGGATAAATCAACCCAGACTACTGGCCGAGAGCTC

AAGAAGGAGACAACACCCACTCCTTCTCAGAGAGAAAGCCAATCATCGAAA

GCCAGGATGGCGGCTCAAATTGCTTCTGGCCCTCCAGCCCTTGAATGGTCGGC

T ACC AATGAAGAGGATGATCT AT C AGT GGAGGCTGAGATCGCTC ACC AGATT

GCAGAAAGTTTCTCCAAAAAATATAAGTTTCCCTCTCGATCCTCAGGGATACT

CTTGTATAATTTTGAGCAATTGAAAATGAACCTTGATGATATAGTTAAAGAGG

CAAAAAATGTACCAGGTGTGACCCGTTTAGCCCATGACGGGTCCAAACTCCC

CCTAAGATGTGTACTGGGATGGGTCGCTTTGGCCAACTCTAAGAAATTCCAGT

T GTT AGT C GA AT C CGAC A AGC T GAGT A A A AT CAT GCA AGAT GAC TT GA ATCG

CTATACATCTTGCTAACCGAACCTCTCCCCTCAGTCCCTCTAGACAATAAAAT

CC GAGAT GT C CC A A AGTC A AC AT GA A A A A A AC AGGC A AC AC C AC T GAT AAA

ATGAACCTCCTACGTAAGATAGTGAAAAACCGCAGGGACGAGGACACTCAA

AAATCCTCTCCCGCGTCAGCCCCTCTGGATGACGATGACTTGTGGCTTCCACC CCCTGAATACGTCCCGCTGAAAGAACTTACAGGCAAGAAGAACATGAGGAAC

TTTTGTATCAACGGAAGGGTTAAAGTGTGTAGCCCGAATGGTTACTCGTTCAG

GATCCTGCGGCACATTCTGAAATCATTCGACGAGATATATTCTGGGAATCATA

GGATGATCGGGTTAGTCAAAGTGGTTATTGGACTGGCTTTGTCAGGATCTCCA

GTCCCTGAGGGCCTGAACTGGGTATACAAATTGAGGAGAACCTTTATCTTCCA

GT GGGCTGATTCC AGGGGCCCTCTT GAAGGGGAGGAGTT GGAAT ACTCTC AG

GAG AT C AC TT GGG AT GAT GAT ACT G AGT T C GT C GG AT T GCA A AT A AG AGT G A

TTGCAAAACAGTGTCATATCCAGGGCAGAGTCTGGTGTATCAACATGAACCC

GAGAGCATGTCAACTATGGTCTGACATGTCTCTTCAGACACAAAGGTCCGAA

GAGGACAAAGATTCCTCTCTGCTTCTAGAATAATCAGATTATATCCCGCAAAT

TTATCACTTGTTTACCTCTGGAGGAGAGAACATATGGGCTCAACTCCAACCCT

TGGGAGCAATATAACAAAAAACATGTTATGGTGCCATTAAACCGCTGCATTT

CATCAAAGTCAAGTTGATTACCTTTACATTTTGATCCTCTTGGATGTGAAAAA

AACTATTAACATCCCTCAAAAGACCccgggAAAGATGGTTCCTCAGGCTCTCCT

GTTTGTACCCCTTCTGGTTTTTCCATTGTGTTTTGGGAAATTCCCTATTTACAC

GATACCAGACAAGCTTGGTCCCTGGAGTCCGATTGACATACATCACCTCAGCT

GCCCAAACAATTTGGTAGTGGAGGACGAAGGATGCACCAACCTGTCAGGGTT

CTCCTACATGGAACTTAAAGTTGGATACATCTTAGCCATAAAAGTGAACGGG

TTCACTTGCACAGGCGTTGTGACGGAGGCTGAAACCTACACTAACTTCGTTGG

TTATGTCACAACCACGTTCAAAAGAAAGCATTTCCGCCCAACACCAGATGCA

TGTAGAGCCGCGTACAACTGGAAGATGGCCGGTGACCCCAGATATGAAGAGT

CTCTACACAATCCGTACCCTGACTACCGCTGGCTTCGAACTGTAAAAACCACC

AAGGAGTCTCTCGTTATCATATCTCCAAGTGTGGCAGATTTGGACCCATATGA

CAGATCCCTTCACTCGAGGGTCTTCCCTAGCGGGAAGTGCTCAGGAGTAGCG

GTGTCTTCTACCTACTGCTCCACTAACCACGATTACACCATTTGGATGCCCGA

GA ATCC GAGACT AGGGAT GT C TT GT G AC ATTTTT AC C A AT AGT AG AGGGA AG

AGAGC ATCC AAAGGGAGTGAGACTT GCGGCTTT GT AG AT GAAAGAGGCCT AT

ATAAGTCTTTAAAAGGAGCATGCAAACTCAAGTTATGTGGAGTTCTAGGACTT

AG AC TT AT GG AT GG A AC AT GGGT C T C GAT GCA A AC AT C A A AT G A A AC C A A AT

GGTGCCCTCCCGATAAGTTGGTGAACCTGCACGACTTTCGCTCAGACGAAATT

GAGC ACCTTGTTGT AGAGGAGTT GGT C AGGAAGAGAGAGGAGTGTCTGGAT G

CACTAGAGTCCATCATGACAACCAAGTCAGTGAGTTTCAGACGTCTCAGTCAT

TTAAGAAAACTTGTCCCTGGGTTTGGAAAAGCATATACCATATTCAACAAGA

CCTT GAT GGAAGCCGAT GCTC ACT AC AAGT C AGT Cgag ACTT GGAAT GAG AT C CTCCCTT C A AAAGGGTGTTT AAGAGTT GGGGGGAGGT GT C ATCCTC ATGT GA

ACGGGGTGTTTTTCAATGGTATAATATTAGGACCTGACGGCAATGTCTTAATC

CCAGAGATGCAATCATCCCTCCTCCAGCAACATATGGAGTTGTTGGAATCCTC

GGTTATCCCCCTTGTGCACCCCCTGGCAGACCCGTCTACCGTTTTCAAGGACG

GTGACGAGGCTGAGGATTTTGTTGAAGTTCACCTTCCCGATGTGCACAATCAG

GTCTCAGGAGTTGACTTGGGTCTCCCGAACTGGGGG AAGT ATGT ATT ACTGA

GTGCAGGGGCCCTGACTGCCTTGATGTTGATAATTTTCCTGATGACATGTTGT

AGAAGAGTCAATCGATCAGAACCTACGCAACACAATCTCAGAGGGACAGGG

AGGGAGGT GTC AGT C ACTCCCC AAAGCGGGAAGAT CAT ATCTTC AT GGGAAT

CACACAAGAGTGGGGGTGAGACCAGACTGTAAttaattaaCGTCCTTTCAACGATC

C A AGT C catgaaaaaaactaacacccctcccgtacctagcTT AT A A AGT GC T GGGT C ATCT A AGCT

TTTCAGTCGAGAAAAAAACATTAGATCAGAAGAACAACTGGCAACACTTCTC

AACCTGAGACTTACTTCAAGATGCTCGATCCTGGAGAGGTCTATGATGACCCT

ATTGACCCAATCGAGTTAGAGGCTGAACCCAGAGGAACCCCCATTGTCCCCA

ACATCTTGAGGAACTCTGACTACAATCTCAACTCTCCTTTGATAGAAGATCCT

GCTAGACTAATGTTAGAATGGTTAAAAACAGGGAATAGACCTTATCGGATGA

CTCTAACAGACAATTGCTCCAGGTCTTTCAGAGTTTTGAAAGATTATTTCAAG

AAGGTAGATTTGGGTTCTCTCAAGGTGGGCGGAATGGCTGCACAGTCAATGA

TTTCTCTCTGGTTATATGGTGCCCACTCTGAATCCAACAGGAGCCGGAGATGT

ATAACAGACTTGGCCCATTTCTATTCCAAGTCGTCCCCCATAGAGAAGCTGTT

GAATCTCACGCTAGGAAATAGAGGGCTGAGAATCCCCCCAGAGGGAGTGTTA

AGTTGCCTTGAGAGGGTTGATTATGATAATGCATTTGGAAGGTATCTTGCCAA

CACGTATTCCTCTTACTTGTTCTTCCATGTAATCACCTTATACATGAACGCCCT

AGACTGGGATGAAGAAAAGACCATCCTAGCATTATGGAAAGATTTAACCTCA

GT GGAC ATCGGGA AGGACTTGGT AA AGTT C AAAGACC AAAT AT GGGGACTGC

TGATCGTGACAAAGGACTTTGTTTACTCCCAAAGTTCCAATTGTCTTTTTGAC

AGAAACTACACACTTATGCTAAAAGATCTTTTCTTGTCTCGCTTCAACTCCTT

AATGGTCTTGCTCTCTCCCCCAGAGCCCCGATACTCAGATGACTTGATATCTC

AACTATGCCAGCTGTACATTGCTGGGGATCAAGTCTTGTCTATGTGTGGAAAC

TCCGGC T AT GA AGT CAT C A A A AT ATT GGAGC CAT AT GT C GT GA AT AGTTT AGT

CCAGAGAGCAGAAAAGTTTAGGCCTCTCATTCATTCCTTGGGAGACTTTCCTG

TATTTATAAAAGACAAGGTAAGTCAACTTGAAGAGACGTTCGGTCCCTGTGC

AAGAAGGTTCTTTAGGGCTCTGGATCAATTCGACAACATACATGACTTGGTTT

TTGTGTTTGGCTGTTACAGGCATTGGGGGCACCCATATATAGATTATCGAAAG GGTCTGTC A A A ACT AT AT GAT C AGGTT C ACC TT A A A A A A AT GAT AG AT A AGT

CC T AC C AGGAGT GC TT AGC A AGC GACC T AGC C AGGAGGAT C CTT AGAT GGGG

TTTTGATAAGTACTCCAAGTGGTATCTGGATTCAAGATTCCTAGCCCGAGACC

ACCCCTTGACTCCTTATATCAAAACCCAAACATGGCCACCCAAACATATTGTA

GACTTGGTGGGGGATACATGGCACAAGCTCCCGATCACGCAGATCTTTGAGA

TTCCTGAATCAATGGATCCGTCAGAAATATTGGATGACAAATCACATTCTTTC

ACCAGAACGAGACTAGCTTCTTGGCTGTCAGAAAACCGAGGGGGGCCTGTTC

CTAGCGAAAAAGTTATTATCACGGCCCTGTCTAAGCCGCCTGTCAATCCCCGA

GAGTTTCTGAGGTCTATAGACCTCGGAGGATTGCCAGATGAAGACTTGATAA

TTGGCCTC AAGCC AAAGGAACGGGAATTGAAGATT GAAGGTCGATTCTTTGC

TCTAATGTCATGGAATCTAAGATTGTATTTTGTCATCACTGAAAAACTCTTGG

CCAACTACATCTTGCCACTTTTTGACGCGCTGACTATGACAGACAACCTGAAC

AAGGTGTTTAAAAAGCTGATCGACAGGGTCACCGGGCAAGGGCTTTTGGACT

ATTC AAGGGT C AC AT AT GC ATTT C ACCTGGACT AT GAAAAGT GGAAC AACC A

TCAAAGATTAGAGTCAACAGAGGATGTATTTTCTGTCCTAGATCAAGTGTTTG

GATTGAAGAGAGTGTTTTCTAGAACACACGAGTTTTTTCAAAAGGCCTGGATC

T ATT ATT C AGAC AGAT C AGACCTC ATCGGGTT ACGGGAGGAT C AAAT AT ACT

GCTTAGATGCGTCCAACGGCCCAACCTGTTGGAATGGCCAGGATGGCGGGCT

AGA AGGC TT ACGGC AGA AGGGCTGG AGT C T AGT C AGC TT ATT GAT GAT AGAT

AGAGAATCTC AAAT C AGGAAC AC A AGAACC AAAAT ACT AGCTC A AGGAGAC

AACCAGGTTTTATGTCCGACATACATGTTGTCGCCAGGGCTATCTCAAGAGGG

GCTCCTCTATGAATTGGAGAGAATATCAAGGAATGCACTTTCGATATACAGA

GC C GT C G AGG A AGGGGC ATC T A AGC T AGGGC T GAT CAT C A AG A A AG A AG AG

ACCATGTGTAGTTATGACTTCCTCATCTATGGAAAAACCCCTTTGTTTAGAGG

TAACATATTGGTGCCTGAGTCCAAAAGATGGGCCAGAGTCTCTTGCGTCTCTA

ATGACCAAATAGTCAACCTCGCCAATATAATGTCGACAGTGTCCACCAATGC

GCTAACAGTGGCACAACACTCTCAATCTTTGATCAAACCGATGAGGGATTTTC

TGCTCATGTCAGTACAGGCAGTCTTTCACTACCTGCTATTTAGCCCAATCTTA

AAGGGAAGAGTTT AC AAGATTCTGAGCGCTGAAGGGGAGAGCTTTCTCCT AG

CCATGTCAAGGATAATCTATCTAGATCCTTCTTTGGGAGGGATATCTGGAATG

TCCCTCGGAAGATTCCATATACGACAGTTCTCAGACCCTGTCTCTGAAGGGTT

ATCCTTCTGGAGAGAGATCTGGTTAAGCTCCCAAGAGTCCTGGATTCACGCGT

T GTGT C AAGAGGCTGGAAACCC AGATCTTGGAGAGAGAAC ACTCGAGAGCTT

CACTCGCCTTCTAGAAGATCCGACCACCTTAAATATCAGAGGAGGGGCCAGT CCTACCATTCTACTCAAGGATGCAATCAGAAAGGCTTTATATGACGAGGTGG

ACAAGGTGGAAAATTCAGAGTTTCGAGAGGCAATCCTGTTGTCCAAGACCCA

TAGAGATAATTTTATACTCTTCTTAATATCTGTTGAGCCTCTGTTTCCTCGATT

TCTCAGTGAGCTATTCAGTTCGTCTTTTTTGGGAATCCCCGAGTCAATCATTG

GATTGATACAAAACTCCCGAACGATAAGAAGGCAGTTTAGAAAGAGTCTCTC

AAAAACTTTAGAAGAATCCTTCTACAACTCAGAGATCCACGGGATTAGTCGG

ATGACCCAGACACCTCAGAGGGTTGGGGGGGTGTGGCCTTGCTCTTCAGAGA

GGGCAGATCTACTTAGGGAGATCTCTTGGGGAAGAAAAGTGGTAGGCACGAC

AGTTCCTCACCCTTCTGAGATGTTGGGATTACTTCCCAAGTCCTCTATTTCTTG

C AC TT GT GGAGC A AC AGGAGGAGGC A ATCC T AGAGTTTC T GT AT C AGT ACTC

CCGTCCTTTGATCAGTCATTTTTTTCACGAGGCCCCCTAAAGGGATACTTGGG

CTCGTCCACCTCTATGTCGACCCAGCTATTCCATGCATGGGAAAAAGTCACTA

AT GTT CAT GT GGT G A AG AG AGC T C T ATC GTT A A A AG A AT C T AT A A AC T GGTT C

ATTACTAGAGATTCCAACTTGGCTCAAGCTCTAATTAGGAACATTATGTCTCT

GACAGGCCCTGATTTCCCTCTAGAGGAGGCCCCTGTCTTCAAAAGGACGGGG

T C AGCCTT GC AT AGGTT C A AGTCTGCC AGAT AC AGCGAAGGAGGGT ATTCTTC

TGTCTGCCCGAACCTCCTCTCTCATATTTCTGTTAGTACAGACACCATGTCTGA

TTTGACCCAAGACGGGAAGAACTACGATTTCATGTTCCAGCCATTGATGCTTT

AT GC AC AG AC AT GGAC AT C AGAGCTGGT AC AGAGAGAC AC AAGGCT AAGAG

ACTCTACGTTTCATTGGCACCTCCGATGCAACAGGTGTGTGAGACCCATTGAC

GACGTGACCCTGGAGACCTCTCAGATCTTCGAGTTTCCGGATGTGTCGAAAA

GAATATCCAGAATGGTTTCTGGGGCTGTGCCTCACTTCCAGAGGCTTCCCGAT

ATCCGTCTGAGACCAGGAGATTTTGAATCTCTAAGCGGTAGAGAAAAGTCTC

ACCATATCGGATCAGCTCAGGGGCTCTTATACTCAATCTTAGTGGCAATTCAC

GACTCAGGATACAATGATGGAACCATCTTCCCTGTCAACATATACGGCAAGG

TTTCCCCTAGAGACTATTTGAGAGGGCTCGCAAGGGGAGTATTGATAGGATC

CTCGATTTGCTTCTTGACAAGAATGACAAATATCAATATTAATAGACCTCTTG

AATTGGTCTCAGGGGTAATCTCATATATTCTCCTGAGGCTAGATAACCATCCC

TCCTTGTACATAATGCTCAGAGAACCGTCTCTTAGAGGAGAGATATTTTCTAT

CCCTCAGAAAATCCCCGCCGCTTATCCAACCACTATGAAAGAAGGCAACAGA

TCAATCTTGTGTTATCTCCAACATGTGCTACGCTATGAGCGAGAGATAATCAC

GGCGTCTCCAGAGAATGACTGGCTATGGATCTTTTCAGACTTTAGAAGTGCCA

AAATGACGTACCTATCCCTCATTACTTACCAGTCTCATCTTCTACTCCAGAGG

GTTGAGAGAA ACCT ATCT AAGAGT ATGAGAGAT AACCTGCGAC A ATT GAGTT CTTTGATGAGGCAGGTGCTGGGCGGGCACGGAGAAGATACCTTAGAGTCAGA

CGACAACATTCAACGACTGCTAAAAGACTCTTTACGAAGGACAAGATGGGTG

GATCAAGAGGTGCGCCATGCAGCTAGAACCATGACTGGAGATTACAGCCCCA

AC AAGAAGGTGTCCCGT AAGGT AGGAT GTT C AGAAT GGGTCTGCTCTGCTC A

ACAGGTTGCAGTCTCTACCTCAGCAAACCCGGCCCCTGTCTCGGAGCTTGACA

TAAGGGCCCTCTCTAAGAGGTTCCAGAACCCTTTGATCTCGGGCTTGAGAGTG

GTTCAGTGGGCAACCGGTGCTCATTATAAGCTTAAGCCTATTCTAGATGATCT

CAATGTTTTCCCATCTCTCTGCCTTGTAGTTGGGGACGGGTCAGGGGGGATAT

CAAGGGCAGTCCTCAACATGTTTCCAGATGCCAAGCTTGTGTTCAACAGTCTT

TTAGAGGTGAATGACCTGATGGCTTCCGGAACACATCCACTGCCTCCTTCAGC

AATCATGAGGGGAGGAAATGATATCGTCTCCAGAGTGATAGATCTTGACTCA

ATCTGGGAAAAACCGTCCGACTTGAGAAACTTGGCAACCTGGAAATACTTCC

AGTCAGTCCAAAAGCAGGTCAACATGTCCTATGACCTCATTATTTGCGATGCA

GAAGTTACTGACATTGCATCTATCAACCGGATCACCCTGTTAATGTCCGATTT

TGCATTGTCTATAGATGGACCACTCTATTTGGTCTTCAAAACTTATGGGACTA

TGCTAGTAAATCCAAACTACAAGGCTATTCAACACCTGTCAAGAGCGTTCCCC

TCGGTCACAGGGTTTATCACCCAAGTAACTTCGTCTTTTTCATCTGAGCTCTAC

CTCCGATTCTCCAAACGAGGGAAGTTTTTCAGAGATGCTGAGTACTTGACCTC

TTCCACCCTTCGAGAAATGAGCCTTGTGTTATTCAATTGTAGCAGCCCCAAGA

GT GAG AT GC AGAGAGCTCGTTCCTTGAACT AT C AGGATCTTGT GAGAGGATTT

CCTGAAGAAATCATATCAAATCCTTACAATGAGATGATCATAACTCTGATTGA

CAGTGATGTAGAATCTTTTCTAGTCCACAAGATGGTTGATGATCTTGAGTTAC

AGAGGGGAACTCTGTCTAAAGTGGCTATCATTATAGCCATCATGATAGTTTTC

TCCAACAGAGTCTTCAACGTTTCCAAACCCCTAACTGACCCCTCGTTCTATCC

ACCGTCTGATCCCAAAATCCTGAGGCACTTCAACATATGTTGCAGTACTATGA

TGTATCTATCTACTGCTTTAGGTGACGTCCCTAGCTTCGCAAGACTTCACGAC

CTGTATAACAGACCTATAACTTATTACTTCAGAAAGCAAGTCATTCGAGGGA

ACGTTTATCTATCTTGGAGTTGGTCCAACGACACCTCAGTGTTCAAAAGGGTA

GCCTGTAATTCTAGCCTGAGTCTGTCATCTCACTGGATCAGGTTGATTTACAA

GATAGTGAAGACTACCAGACTCGTTGGCAGCATCAAGGATCTATCCAGAGAA

GTGGAAAGACACCTTCATAGGTACAACAGGTGGATCACCCTAGAGGATATCA

GATCTAGATCATCCCTACTAGACTACAGTTGCCTGTGAACCGGATACTCCTGG

AAGCCTGCCCATGCTAAGACTCTTGTGTGATGTATCTTGAAAAAAACAAGAT

CCT AAATCTGAACCTTT GGTT GTTT GATT GTTTTTCTC Atttttgttgtttatttgttaagcgt In one embodiment, the nucleic acid comprises the sequence of SEQ ID NO: 14, shown below (RABV vector: Coravax V5 China):

ACGCTTAACAACCAGATCAAAGAAAAAACAGACATTGTCAATTGCAAAGCAA

AAATGTAACACCCCTACAATGGATGCCGACAAGATTGTATTCAAAGTCAATA

AT C AGGT GGT C TC TT T G A AGC C T GAG AT T AT C GT GG AT C A AT AT G AGT AC A AG

TACCCTGCCATCAAAGATTTGAAAAAGCCCTGTATAACCCTAGGAAAGGCTC

CCGATTTAAATAAAGCATACAAGTCAGTTTTGTCAGGCATGAGCGCCGCCAA

ACTTAATCCTGACGATGTATGTTCCTATTTGGCAGCGGCAATGCAGTTTTTTG

AGGGGACATGTCCGGAAGACTGGACCAGCTATGGAATTGTGATTGCACGAAA

AGGAGATAAGATCACCCCAGGTTCTCTGGTGGAGATAAAACGTACTGATGTA

GAAGGGAATT GGGCTCTGAC AGGAGGC AT GGAACTGAC AAGAGACCCC ACT

GTCCCTGAGCATGCGTCCTTAGTCGGTCTTCTCTTGAGTCTGTATAGGTTGAG

CAAAATATCCGGGCAAAACACTGGTAACTATAAGACAAACATTGCAGACAGG

ATAGAGCAGATTTTTGAGACAGCCCCTTTTGTTAAAATCGTGGAACACCATAC

TCTAATGACAACTCACAAAATGTGTGCTAATTGGAGTACTATACCAAACTTCA

GATTTTTGGCCGGAACCTATGACATGTTTTTCTCCCGGATTGAGCATCTATATT

CAGCAATCAGAGTGGGCACAGTTGTCACTGCTTATGAAGACTGTTCAGGACT

GGTATCATTTACTGGGTTCATAAAACAAATCAATCTCACCGCTAGAGAGGCA

ATACTATATTTCTTCCACAAGAACTTTGAGGAAGAGATAAGAAGAATGTTTG

AGCCAGGGCAGGAGACAGCTGTTCCTCACTCTTATTTCATCCACTTCCGTTCA

CTAGGCTTGAGTGGGAAATCTCCTTATTCATCAAATGCTGTTGGTCACGTGTT

CAATCTCATTCACTTTGTAGGATGCTATATGGGTCAAGTCAGATCCCTAAATG

CAACGGTTATTGCTGCATGTGCTCCTCATGAAATGTCTGTTCTAGGGGGCTAT

CTGGGAGAGGAATTCTTCGGGAAAGGGAC ATTTGAAAGAAGATTCTTC AGAG

AT GAG A A AG A AC TT C A AG A AT AC G AGGC GGC T G A AC T G AC A A AG AC T G AC G

TAGCACTGGCAGATGATGGAACTGTCAACTCTGACGACGAGGACTACTTTTC

AGGT GAAACC AGAAGTCCGGAGGCTGTTT AT ACTCGAAT CAT GAT GAAT GGA

GGTCGACTAAAGAGATCTCACATACGGAGATATGTCTCAGTCAGTTCCAATC

ATCAAGCCCGTCCAAACTCATTCGCCGAGTTTCTAAACAAGACATATTCGAGT

GACTCATAAGAAGTTGAATAACAAAATGCCGGAAATCTACGGATTGTGTATA

TCCATCATGAAAAAAACTAACACCCCTCCTTTCGAACCATCCCAAACATGAG

CAAGATCTTTGTCAATCCTAGTGCTATTAGAGCCGGTCTGGCCGATCTTGAGA

T GGCTGAAGAAACTGTTGATCTGAT C AAT AGAAAT ATCGAAGAC AAT C AGGC

TCATCTCCAAGGGGAACCCATAGAGGTGGACAATCTCCCTGAGGATATGGGG CGACTTCACCTGGATGATGGAAAATCGCCCAACCATGGTGAGATAGCCAAGG

T GGG AG A AGGC A AGT ATC G AG AGG AC T T T C AG AT GG AT G A AGG AG AGG AT C

CTAGCTTCCTGTTCCAGTCATACCTGGAAAATGTTGGAGTCCAAATAGTCAGA

CAAATGAGGTCAGGAGAGAGATTTCTCAAGATATGGTCACAGACCGTAGAAG

AGATTATATCCTATGTCGCGGTCAACTTTCCCAACCCTCCAGGAAAGTCTTCA

GAGGATAAATCAACCCAGACTACTGGCCGAGAGCTCAAGAAGGAGACAACA

CCCACTCCTTCTCAGAGAGAAAGCCAATCATCGAAAGCCAGGATGGCGGCTC

AAATTGCTTCTGGCCCTCCAGCCCTTGAATGGTCGGCTACCAATGAAGAGGAT

GATCTATCAGTGGAGGCTGAGATCGCTCACCAGATTGCAGAAAGTTTCTCCA

AAAAATATAAGTTTCCCTCTCGATCCTCAGGGATACTCTTGTATAATTTTGAG

C AATTGAAAAT GAACCTTGAT GAT AT AGTT AAAGAGGC AAAAAAT GT ACC AG

GTGTGACCCGTTTAGCCCATGACGGGTCCAAACTCCCCCTAAGATGTGTACTG

GGATGGGTCGCTTTGGCCAACTCTAAGAAATTCCAGTTGTTAGTCGAATCCGA

CAAGCTGAGTAAAATCATGCAAGATGACTTGAATCGCTATACATCTTGCTAA

CCGAACCTCTCCCCTCAGTCCCTCTAGACAATAAAATCCGAGATGTCCCAAAG

TCAACATGAAAAAAACAGGCAACACCACTGATAAAATGAACCTCCTACGTAA

GATAGTGAAAAACCGCAGGGACGAGGACACTCAAAAATCCTCTCCCGCGTCA

GCCCCTCTGGATGACGATGACTTGTGGCTTCCACCCCCTGAATACGTCCCGCT

GA A AGA ACTT AC AGGC A AG A AG A AC AT GAGGA AC TTTTGT AT C A AC GGA AG

GGTTAAAGTGTGTAGCCCGAATGGTTACTCGTTCAGGATCCTGCGGCACATTC

TGAAATCATTCGACGAGATATATTCTGGGAATCATAGGATGATCGGGTTAGTC

AAAGTGGTTATTGGACTGGCTTTGTCAGGATCTCCAGTCCCTGAGGGCCTGAA

CTGGGTATACAAATTGAGGAGAACCTTTATCTTCCAGTGGGCTGATTCCAGGG

GCCCTCTTGAAGGGGAGGAGTTGGAATACTCTCAGGAGATCACTTGGGATGA

T GAT AC T G AGTTCGTCGGATTGC A A AT A AG AGT GATT GCA A A AC AGT GT CAT

ATCC AGGGC AGAGTCTGGT GT AT C AAC AT GAACCCGAGAGC ATGT C AACT AT

GGTCTGACATGTCTCTTCAGACACAAAGGTCCGAAGAGGACAAAGATTCCTC

TCTGCTTCTAGAATAATCAGATTATATCCCGCAAATTTATCACTTGTTTACCTC

TGGAGGAGAGAACATATGGGCTCAACTCCAACCCTTGGGAGCAATATAACAA

AAAAC AT GTT ATGGT GCC ATT AAACCGCTGC ATTT CAT C AAAGTC AAGTT GAT

TACCTTTACATTTTGATCCTCTTGGATGTGAAAAAAACTATTAACATCCCTCA

AAAGACCccgggccaccATGTTCGTGTTTCTGGTGCTGCTGCCTCTGGTGAGCTCC

CAGTGCGTGAACCTGACCACAAGGACCCAGCTGCCCCCTGCCTATACCAATT

CCTTCACACGGGGCGTGTACTATCCCGACAAGGTGTTCCGGAGCAGCGTGCT GCACTCCACACAGGATCTGTTTCTGCCTTTCTTTTCTAACGTGACCTGGTTCCA

CGCCATCCACGTGAGCGGCACCAATGGCACAAAGCGGTTCGACAATCCAGTG

CTGCCCTTTAACGATGGCGTGTACTTCGCCTCCACCGAGAAGTCTAACATCAT

CAGAGGCTGGATCTTTGGCACCACACTGGACAGCAAGACACAGTCCCTGCTG

ATCGTGAACAATGCCACCAACGTGGTCATCAAGGTGTGCGAGTTCCAGTTTTG

TAATGATCCATTCCTGGGCGTGTACTATCACAAGAACAATAAGTCTTGGATGG

AGAGCGAGTTTCGCGTGTATTCCTCTGCCAACAATTGCACATTTGAGTACGTG

TCCCAGCCCTTCCTGATGGACCTGGAGGGCAAGCAGGGCAATTTCAAGAACC

TGAGGGAGTTCGTGTTTAAGAATATCGATGGCTACTTCAAAATCTACTCCAAG

CACACCCCAATCAACCTGGTGCGCGACCTGCCACAGGGCTTCTCTGCCCTGGA

GCCACTGGTGGATCTGCCCATCGGCATCAACATCACCCGGTTTCAGACACTGC

TGGCCCTGCACAGAAGCTACCTGACACCAGGCGACAGCTCCTCTGGATGGAC

CGCAGGAGCAGCAGCCTACTATGTGGGCTATCTGCAGCCCAGGACCTTCCTG

CTGAAGTACAACGAGAATGGCACCATCACAGACGCCGTGGATTGCGCCCTGG

ATCCCCTGTCTGAGACCAAGTGTACACTGAAGAGCTTTACCGTGGAGAAGGG

CATCTATCAGACAAGCAATTTCAGGGTGCAGCCTACCGAGTCCATCGTGCGCT

TTCCCAATATCACAAACCTGTGCCCTTTTGGCGAGGTGTTCAACGCAACCCGC

TTCGCCAGCGTGTACGCCTGGAATAGGAAGCGCATCTCCAACTGCGTGGCCG

ACTATTCTGTGCTGTACAACAGCGCCTCCTTCTCTACCTTTAAGTGCTATGGC

GTGAGCCCCACAAAGCTGAATGACCTGTGCTTTACCAACGTGTACGCCGATTC

CTTCGTGATCAGGGGCGACGAGGTGCGCCAGATCGCACCAGGACAGACAGGC

AAGATCGCAGACTACAATTATAAGCTGCCTGACGATTTCACCGGCTGCGTGA

TCGCCTGGAACTCTAACAATCTGGATAGCAAAGTGGGCGGCAACTACAATTA

TCTGTACCGGCTGTTTAGAAAGTCTAATCTGAAGCCATTCGAGAGGGACATCT

CCACAGAAATCTACCAGGCCGGCTCTACCCCCTGCAATGGCGTGGAgGGCTTT

AACTGTTATTTCCCTCTGCAGAgCTACgGCTTCCAGCCAACAAACGGCGTGGG

CTATCAGCCCTACCGCGTGGTGGTGCTGTCTTTTGAGCTGCTGCACGCACcTG

C A AC AGT GT GC GGACC A A AGA AGAGC AC C A ATCTGGT GA AGA AC A AGT GC G

TGAACTTCAACTTCAACGGACTGACCGGAACAGGCGTGCTGACCGAGTCCAA

CAAGAAGTTCCTGCCTTTTCAGCAGTTCGGCAGGGACATCGCAGATACCACA

GACGCCGTGCGCGACCCTCAGACCCTGGAGATCCTGGACATCACACCATGCT

CCTTCGGCGGCGTGTCTGTGATCACACCAGGCACCAATACAAGCAACCAGGT

GGCCGT GCTGT AT C AGGACGT GAATT GT ACCGAGGTGCC AGT GGC AATCC AC

GCAGATCAGCTGACCCCTACATGGCGGGTGTACTCTACCGGCAGCAACGTGT TCCAGACAAGAGCCGGATGCCTGATCGGAGCAGAGCACGTGAACAATAGCTA

TGAGTGCGACATCCCTATCGGCGCCGGCATCTGTGCCTCCTACCAGACCCAGA

CAAACTCCCCAAGGTCTgtgggaGATGAGGCCGAAGACTTTGTGGAAGTCCACC

TGCCTGATGTGCATAACCAGGTGTCTGGCGTCGACCTGGGACTGCCAAATTG

GGGCAAGTACGTGCTGCTGAGTGCTGGAGCACTGACTGCCCTGATGCTGATC

ATTTTCCTGATGACCTGCTGTCGGCGCGTGAACAGAAGTGAGCCCACTCAGC

AC AATCTGCGAGGAACCGGGAGAGAAGT GTC AGT C AC ACCTC AGAGCGGGA

AAAT C ATT AGT AGTTGGGAAT C AC AT AAAAGCGGGGGCGAGACC AGGCTGgg atccggctccggcgagggcaggggaagtctactaacatgcggggacgtggaggaaaatcccggccccATGGTTCCT

CAGGCTCTCCTGTTTGTACCCCTTCTGGTTTTTCCATTGTGTTTTGGGAAATTC

CCTATTTACACGATACCAGACAAGCTTGGTCCCTGGAGTCCGATTGACATACA

TCACCTCAGCTGCCCAAACAATTTGGTAGTGGAGGACGAAGGATGCACCAAC

CTGTCAGGGTTCTCCTACATGGAACTTAAAGTTGGATACATCTTAGCCATAAA

AGTGAACGGGTTCACTTGCACAGGCGTTGTGACGGAGGCTGAAACCTACACT

AACTTCGTTGGTTATGTCACAACCACGTTCAAAAGAAAGCATTTCCGCCCAAC

ACCAGATGCATGTAGAGCCGCGTACAACTGGAAGATGGCCGGTGACCCCAGA

TATGAAGAGTCTCTACACAATCCGTACCCTGACTACCGCTGGCTTCGAACTGT

AAAAACCACCAAGGAGTCTCTCGTTATCATATCTCCAAGTGTGGCAGATTTGG

ACCCATATGACAGATCCCTTCACTCGAGGGTCTTCCCTAGCGGGAAGTGCTCA

GGAGTAGCGGTGTCTTCTACCTACTGCTCCACTAACCACGATTACACCATTTG

GATGCCCGAGAATCCGAGACTAGGGATGTCTTGTGACATTTTTACCAATAGTA

GAGGGAAGAGAGC ATCC AAAGGGAGT GAGACTT GCGGCTTT GT AGATGAAA

G AGGC C T AT AT A AGT C T TT A A A AGG AGC AT GCA A AC T C A AGTT AT GT GG AGT

TCTAGGACTTAGACTTATGGATGGAACATGGGTCTCGATGCAAACATCAAAT

GAAACCAAATGGTGCCCTCCCGATAAGTTGGTGAACCTGCACGACTTTCGCTC

AGACGAAATTGAGCACCTTGTTGTAGAGGAGTTGGTCAGGAAGAGAGAGGA

GTGTCTGGATGCACTAGAGTCCATCATGACAACCAAGTCAGTGAGTTTCAGA

CGTCTCAGTCATTTAAGAAAACTTGTCCCTGGGTTTGGAAAAGCATATACCAT

ATTCAACAAGACCTTGATGGAAGCCGATGCTCACTACAAGTCAGTCgagACTT

GGAAT GAGATCCTCCCTT C AAAAGGGT GTTT A AGAGTT GGGGGGAGGTGT C A

TCCTC AT GTGAACGGGGT GTTTTT C AAT GGT AT AAT ATT AGGACCTGACGGC A

ATGTCTTAATCCCAGAGATGCAATCATCCCTCCTCCAGCAACATATGGAGTTG

TTGGAATCCTCGGTTATCCCCCTTGTGCACCCCCTGGCAGACCCGTCTACCGT

TTTCAAGGACGGTGACGAGGCTGAGGATTTTGTTGAAGTTCACCTTCCCGATG TGCACAATCAGGTCTCAGGAGTTGACTTGGGTCTCCCGAACTGGGGGAAGTA

TGTATTACTGAGTGCAGGGGCCCTGACTGCCTTGATGTTGATAATTTTCCTGA

TGACATGTTGTAGAAGAGTCAATCGATCAGAACCTACGCAACACAATCTCAG

AGGGACAGGGAGGGAGGTGTCAGTCACTCCCCAAAGCGGGAAGATCATATCT

T CAT GGGAATC AC AC AAGAGT GGGGGT GAGACC AGACTGT AAgctagcTT AT A A

AGTGCTGGGTCATCTAAGCTTTTCAGTCGAGAAAAAAACATTAGATCAGAAG

AACAACTGGCAACACTTCTCAACCTGAGACTTACTTCAAGATGCTCGATCCTG

GAGAGGTCTATGATGACCCTATTGACCCAATCGAGTTAGAGGCTGAACCCAG

AGGAACCCCCATTGTCCCCAACATCTTGAGGAACTCTGACTACAATCTCAACT

CTCCTTTGATAGAAGATCCTGCTAGACTAATGTTAGAATGGTTAAAAACAGG

GAATAGACCTTATCGGATGACTCTAACAGACAATTGCTCCAGGTCTTTCAGAG

TTTTGAAAGATTATTTCAAGAAGGTAGATTTGGGTTCTCTCAAGGTGGGCGGA

ATGGCTGCACAGTCAATGATTTCTCTCTGGTTATATGGTGCCCACTCTGAATC

CAACAGGAGCCGGAGATGTATAACAGACTTGGCCCATTTCTATTCCAAGTCG

TCCCCCATAGAGAAGCTGTTGAATCTCACGCTAGGAAATAGAGGGCTGAGAA

TCCCCCCAGAGGGAGTGTTAAGTTGCCTTGAGAGGGTTGATTATGATAATGC

ATTTGGAAGGTATCTTGCCAACACGTATTCCTCTTACTTGTTCTTCCATGTAAT

CACCTTATACATGAACGCCCTAGACTGGGATGAAGAAAAGACCATCCTAGCA

TTATGGAAAGATTTAACCTCAGTGGACATCGGGAAGGACTTGGTAAAGTTCA

AAGACCAAATATGGGGACTGCTGATCGTGACAAAGGACTTTGTTTACTCCCA

AAGTTCCAATTGTCTTTTTGACAGAAACTACACACTTATGCTAAAAGATCTTT

TCTTGTCTCGCTTCAACTCCTTAATGGTCTTGCTCTCTCCCCCAGAGCCCCGAT

ACTCAGATGACTTGATATCTCAACTATGCCAGCTGTACATTGCTGGGGATCAA

GTCTTGTCTATGTGTGGAAACTCCGGCTATGAAGTCATCAAAATATTGGAGCC

ATATGTCGTGAATAGTTTAGTCCAGAGAGCAGAAAAGTTTAGGCCTCTCATTC

ATTCCTTGGGAGACTTTCCTGTATTTATAAAAGACAAGGTAAGTCAACTTGAA

GAGACGTTCGGTCCCTGTGCAAGAAGGTTCTTTAGGGCTCTGGATCAATTCGA

CAACATACATGACTTGGTTTTTGTGTTTGGCTGTTACAGGCATTGGGGGCACC

CATATATAGATTATCGAAAGGGTCTGTCAAAACTATATGATCAGGTTCACCTT

A A A A A A AT GAT AG AT A AGTCC T AC C AGGAGT GC TT AGC A AGCGAC CT AGCC A

GGAGGATCCTTAGATGGGGTTTTGATAAGTACTCCAAGTGGTATCTGGATTCA

AGATTCCTAGCCCGAGACCACCCCTTGACTCCTTATATCAAAACCCAAACATG

GCCACCCAAACATATTGTAGACTTGGTGGGGGATACATGGCACAAGCTCCCG

ATCACGCAGATCTTTGAGATTCCTGAATCAATGGATCCGTCAGAAATATTGGA TGACAAATCACATTCTTTCACCAGAACGAGACTAGCTTCTTGGCTGTCAGAAA

ACCGAGGGGGGCCTGTTCCTAGCGAAAAAGTTATTATCACGGCCCTGTCTAA

GCCGCCTGTCAATCCCCGAGAGTTTCTGAGGTCTATAGACCTCGGAGGATTGC

C AGAT GA AGAC TT GAT A ATT GGCC T C A AGCC A A AGGA AC GGGA ATTGA AGAT

TGAAGGTCGATTCTTTGCTCTAATGTCATGGAATCTAAGATTGTATTTTGTCAT

CACTGAAAAACTCTTGGCCAACTACATCTTGCCACTTTTTGACGCGCTGACTA

T GAC AGAC AACCTGAAC AAGGT GTTT AAAAAGCTGATCGAC AGGGT C ACCGG

GCAAGGGCTTTTGGACTATTCAAGGGTCACATATGCATTTCACCTGGACTATG

AAAAGTGGAACAACCATCAAAGATTAGAGTCAACAGAGGATGTATTTTCTGT

CCTAGATCAAGTGTTTGGATTGAAGAGAGTGTTTTCTAGAACACACGAGTTTT

TTCAAAAGGCCTGGATCTATTATTCAGACAGATCAGACCTCATCGGGTTACGG

GAGGATCAAATATACTGCTTAGATGCGTCCAACGGCCCAACCTGTTGGAATG

GCC AGGAT GGCGGGCT AGAAGGCTT ACGGC AGAAGGGCTGGAGTCT AGT C A

GCTT ATT GAT GAT AGAT AGAGAATCTC AAATC AGGAAC AC AAGAACC AAAAT

ACTAGCTCAAGGAGACAACCAGGTTTTATGTCCGACATACATGTTGTCGCCA

GGGC T AT C T C A AG AGGGGC TCCTCTAT G A ATT GG AG AG A AT AT C A AGGA AT G

CACTTTCGATATACAGAGCCGTCGAGGAAGGGGCATCTAAGCTAGGGCTGAT

CAT C A AG A A AG A AG AG AC CAT GT GT AGTT AT GAC TTCCTC ATCT AT GGA A A A

ACCCCTTTGTTTAGAGGTAACATATTGGTGCCTGAGTCCAAAAGATGGGCCA

GAGTCTCTTGCGTCTCTAATGACCAAATAGTCAACCTCGCCAATATAATGTCG

ACAGTGTCCACCAATGCGCTAACAGTGGCACAACACTCTCAATCTTTGATCAA

ACCGATGAGGGATTTTCTGCTCATGTCAGTACAGGCAGTCTTTCACTACCTGC

TATTTAGCCCAATCTTAAAGGGAAGAGTTTACAAGATTCTGAGCGCTGAAGG

GGAGAGCTTTCTCCTAGCCATGTCAAGGATAATCTATCTAGATCCTTCTTTGG

GAGGGAT ATCTGGAATGTCCCTCGGAAGATTCC AT AT ACGAC AGTTCTC AGA

CCCTGTCTCTGAAGGGTTATCCTTCTGGAGAGAGATCTGGTTAAGCTCCCAAG

AGTCCTGGATTCACGCGTTGTGTCAAGAGGCTGGAAACCCAGATCTTGGAGA

GAGAACACTCGAGAGCTTCACTCGCCTTCTAGAAGATCCGACCACCTTAAAT

AT C AG AGG AGGGGC C AGTCC T AC C ATTCT ACTC A AGGAT GCA AT C AGA A AGG

CTTT AT ATGACGAGGT GG AC AAGGT GGAAAATTC AGAGTTTCGAGAGGC AAT

CCTGTTGTCCAAGACCCATAGAGATAATTTTATACTCTTCTTAATATCTGTTGA

GCCTCTGTTTCCTCGATTTCTCAGTGAGCTATTCAGTTCGTCTTTTTTGGGAAT

CCCCGAGTCAATCATTGGATTGATACAAAACTCCCGAACGATAAGAAGGCAG

TTT AGAAAGAGTCTCTC AAAAACTTT AGAAGAATCCTTCT AC AACTC AGAGAT CC ACGGGATT AGTCGGATGACCC AGAC ACCTC AGAGGGTT GGGGGGGT GT GG

CCTTGCTCTTCAGAGAGGGCAGATCTACTTAGGGAGATCTCTTGGGGAAGAA

AAGTGGTAGGCACGACAGTTCCTCACCCTTCTGAGATGTTGGGATTACTTCCC

AAGTCCTCTATTTCTTGCACTTGTGGAGCAACAGGAGGAGGCAATCCTAGAG

TTTCTGTATCAGTACTCCCGTCCTTTGATCAGTCATTTTTTTCACGAGGCCCCC

TAAAGGGATACTTGGGCTCGTCCACCTCTATGTCGACCCAGCTATTCCATGCA

T GGG A A A A AGT C AC T A AT GT TC AT GT GGT G A AG AG AGC TC T AT C GT T A A A AG

AATCTATAAACTGGTTCATTACTAGAGATTCCAACTTGGCTCAAGCTCTAATT

AGGAACATTATGTCTCTGACAGGCCCTGATTTCCCTCTAGAGGAGGCCCCTGT

CTTCAAAAGGACGGGGTCAGCCTTGCATAGGTTCAAGTCTGCCAGATACAGC

GAAGGAGGGTATTCTTCTGTCTGCCCGAACCTCCTCTCTCATATTTCTGTTAGT

ACAGACACCATGTCTGATTTGACCCAAGACGGGAAGAACTACGATTTCATGT

TCC AGCC ATTGAT GCTTT AT GC AC AGAC AT GGAC ATC AGAGCTGGT AC AG AG

AGACACAAGGCTAAGAGACTCTACGTTTCATTGGCACCTCCGATGCAACAGG

TGTGTGAGACCCATTGACGACGTGACCCTGGAGACCTCTCAGATCTTCGAGTT

TCCGGATGTGTCGAAAAGAATATCCAGAATGGTTTCTGGGGCTGTGCCTCACT

TCCAGAGGCTTCCCGATATCCGTCTGAGACCAGGAGATTTTGAATCTCTAAGC

GGTAGAGAAAAGTCTCACCATATCGGATCAGCTCAGGGGCTCTTATACTCAA

TCTTAGTGGCAATTCACGACTCAGGATACAATGATGGAACCATCTTCCCTGTC

AACATATACGGCAAGGTTTCCCCTAGAGACTATTTGAGAGGGCTCGCAAGGG

GAGT ATT GAT AGGATCCTCGATTT GCTTCTT GAC AAGAATGAC AAAT ATC AAT

ATTAATAGACCTCTTGAATTGGTCTCAGGGGTAATCTCATATATTCTCCTGAG

GCTAGATAACCATCCCTCCTTGTACATAATGCTCAGAGAACCGTCTCTTAGAG

GAGAGATATTTTCTATCCCTCAGAAAATCCCCGCCGCTTATCCAACCACTATG

AAAGAAGGCAACAGATCAATCTTGTGTTATCTCCAACATGTGCTACGCTATG

AGCGAGAGATAATCACGGCGTCTCCAGAGAATGACTGGCTATGGATCTTTTC

AGACTTTAGAAGTGCCAAAATGACGTACCTATCCCTCATTACTTACCAGTCTC

ATCTTCTACTCCAGAGGGTTGAGAGAAACCTATCTAAGAGTATGAGAGATAA

CCTGCGACAATTGAGTTCTTTGATGAGGCAGGTGCTGGGCGGGCACGGAGAA

GATACCTTAGAGTCAGACGACAACATTCAACGACTGCTAAAAGACTCTTTAC

GAAGGAC AAGAT GGGTGGATC AAGAGGT GCGCC AT GC AGCT AGAACC AT GA

CTGGAGATTACAGCCCCAACAAGAAGGTGTCCCGTAAGGTAGGATGTTCAGA

ATGGGTCTGCTCTGCTCAACAGGTTGCAGTCTCTACCTCAGCAAACCCGGCCC

CTGTCTCGGAGCTTGACATAAGGGCCCTCTCTAAGAGGTTCCAGAACCCTTTG ATCTCGGGCTTGAGAGTGGTTC AGT GGGC AACCGGT GCTC ATT AT AAGCTT AA

GCCTATTCTAGATGATCTCAATGTTTTCCCATCTCTCTGCCTTGTAGTTGGGGA

CGGGTCAGGGGGGATATCAAGGGCAGTCCTCAACATGTTTCCAGATGCCAAG

CTTGTGTTCAACAGTCTTTTAGAGGTGAATGACCTGATGGCTTCCGGAACACA

TCCACTGCCTCCTTCAGCAATCATGAGGGGAGGAAATGATATCGTCTCCAGA

GTGATAGATCTTGACTCAATCTGGGAAAAACCGTCCGACTTGAGAAACTTGG

CAACCTGGAAATACTTCCAGTCAGTCCAAAAGCAGGTCAACATGTCCTATGA

CCTCATTATTTGCGATGCAGAAGTTACTGACATTGCATCTATCAACCGGATCA

CCCTGTTAATGTCCGATTTTGCATTGTCTATAGATGGACCACTCTATTTGGTCT

T C A A A AC TT AT GGGAC T AT GCT AGT A A ATCC A A ACT AC A AGGC T ATTC A AC A

CCTGTCAAGAGCGTTCCCCTCGGTCACAGGGTTTATCACCCAAGTAACTTCGT

CTTTTTCATCTGAGCTCTACCTCCGATTCTCCAAACGAGGGAAGTTTTTCAGA

GATGCTGAGTACTTGACCTCTTCCACCCTTCGAGAAATGAGCCTTGTGTTATT

CAATTGTAGCAGCCCCAAGAGTGAGATGCAGAGAGCTCGTTCCTTGAACTAT

C AGGATCTT GTGAGAGGATTTCCTGAAGAAAT CAT AT C AAATCCTT AC AAT G

AGATGATCATAACTCTGATTGACAGTGATGTAGAATCTTTTCTAGTCCACAAG

AT GGTT GAT GAT C TT GAGTT AC AGAGGGGA AC TC T GTCT A A AGT GGCT AT CAT

TATAGCCATCATGATAGTTTTCTCCAACAGAGTCTTCAACGTTTCCAAACCCC

TAACTGACCCCTCGTTCTATCCACCGTCTGATCCCAAAATCCTGAGGCACTTC

AACATATGTTGCAGTACTATGATGTATCTATCTACTGCTTTAGGTGACGTCCC

TAGCTTCGCAAGACTTCACGACCTGTATAACAGACCTATAACTTATTACTTCA

GAAAGCAAGTCATTCGAGGGAACGTTTATCTATCTTGGAGTTGGTCCAACGA

CACCTCAGTGTTCAAAAGGGTAGCCTGTAATTCTAGCCTGAGTCTGTCATCTC

ACTGGAT C AGGTTGATTT AC AAGAT AGT GAAGACT ACC AGACTCGTT GGC AG

CATCAAGGATCTATCCAGAGAAGTGGAAAGACACCTTCATAGGTACAACAGG

TGGATCACCCTAGAGGATATCAGATCTAGATCATCCCTACTAGACTACAGTTG

CCTGTGAACCGGATACTCCTGGAAGCCTGCCCATGCTAAGACTCTTGTGTGAT

GTATCTTGAAAAAAACAAGATCCTAAATCTGAACCTTTGGTTGTTTGATTGTT

TTTCTCATTTTTGTTGTTTATTTGTTAAGCGT.

In one embodiment, the nucleic acid comprises the sequence of SEQ ID NO: 15, shown below (RABV vector: Coravax V5 South Africa):

ACGCTTAACAACCAGATCAAAGAAAAAACAGACATTGTCAATTGCAAAGCAA AAATGTAACACCCCTACAATGGATGCCGACAAGATTGTATTCAAAGTCAATA AT C AGGT GGT C TC TT T G A AGC C T GAG AT T AT C GT GG AT C A AT AT G AGT AC A AG TACCCTGCCATCAAAGATTTGAAAAAGCCCTGTATAACCCTAGGAAAGGCTC

CCGATTTAAATAAAGCATACAAGTCAGTTTTGTCAGGCATGAGCGCCGCCAA

ACTTAATCCTGACGATGTATGTTCCTATTTGGCAGCGGCAATGCAGTTTTTTG

AGGGGACATGTCCGGAAGACTGGACCAGCTATGGAATTGTGATTGCACGAAA

AGGAGATAAGATCACCCCAGGTTCTCTGGTGGAGATAAAACGTACTGATGTA

GAAGGGAATT GGGCTCTGAC AGGAGGC AT GGAACTGAC AAGAGACCCC ACT

GTCCCTGAGCATGCGTCCTTAGTCGGTCTTCTCTTGAGTCTGTATAGGTTGAG

CAAAATATCCGGGCAAAACACTGGTAACTATAAGACAAACATTGCAGACAGG

ATAGAGCAGATTTTTGAGACAGCCCCTTTTGTTAAAATCGTGGAACACCATAC

TCTAATGACAACTCACAAAATGTGTGCTAATTGGAGTACTATACCAAACTTCA

GATTTTTGGCCGGAACCTATGACATGTTTTTCTCCCGGATTGAGCATCTATATT

CAGCAATCAGAGTGGGCACAGTTGTCACTGCTTATGAAGACTGTTCAGGACT

GGTATCATTTACTGGGTTCATAAAACAAATCAATCTCACCGCTAGAGAGGCA

ATACTATATTTCTTCCACAAGAACTTTGAGGAAGAGATAAGAAGAATGTTTG

AGCCAGGGCAGGAGACAGCTGTTCCTCACTCTTATTTCATCCACTTCCGTTCA

CTAGGCTTGAGTGGGAAATCTCCTTATTCATCAAATGCTGTTGGTCACGTGTT

CAATCTCATTCACTTTGTAGGATGCTATATGGGTCAAGTCAGATCCCTAAATG

CAACGGTTATTGCTGCATGTGCTCCTCATGAAATGTCTGTTCTAGGGGGCTAT

CTGGGAGAGGAATTCTTCGGGAAAGGGAC ATTTGAAAGAAGATTCTTC AGAG

AT GAG A A AG A AC TT C A AG A AT AC G AGGC GGC T G A AC T G AC A A AG AC T G AC G

TAGCACTGGCAGATGATGGAACTGTCAACTCTGACGACGAGGACTACTTTTC

AGGT GAAACC AGAAGTCCGGAGGCTGTTT AT ACTCGAAT CAT GAT GAAT GGA

GGTCGACTAAAGAGATCTCACATACGGAGATATGTCTCAGTCAGTTCCAATC

ATCAAGCCCGTCCAAACTCATTCGCCGAGTTTCTAAACAAGACATATTCGAGT

GACTCATAAGAAGTTGAATAACAAAATGCCGGAAATCTACGGATTGTGTATA

TCCATCATGAAAAAAACTAACACCCCTCCTTTCGAACCATCCCAAACATGAG

CAAGATCTTTGTCAATCCTAGTGCTATTAGAGCCGGTCTGGCCGATCTTGAGA

T GGCTGAAGAAACTGTTGATCTGAT C AAT AGAAAT ATCGAAGAC AAT C AGGC

TCATCTCCAAGGGGAACCCATAGAGGTGGACAATCTCCCTGAGGATATGGGG

CGACTTCACCTGGATGATGGAAAATCGCCCAACCATGGTGAGATAGCCAAGG

T GGG AG A AGGC A AGT ATC G AG AGG AC T T T C AG AT GG AT G A AGG AG AGG AT C

CTAGCTTCCTGTTCCAGTCATACCTGGAAAATGTTGGAGTCCAAATAGTCAGA

CAAATGAGGTCAGGAGAGAGATTTCTCAAGATATGGTCACAGACCGTAGAAG

AGATTATATCCTATGTCGCGGTCAACTTTCCCAACCCTCCAGGAAAGTCTTCA GAGGATAAATCAACCCAGACTACTGGCCGAGAGCTCAAGAAGGAGACAACA

CCCACTCCTTCTCAGAGAGAAAGCCAATCATCGAAAGCCAGGATGGCGGCTC

AAATTGCTTCTGGCCCTCCAGCCCTTGAATGGTCGGCTACCAATGAAGAGGAT

GATCTATCAGTGGAGGCTGAGATCGCTCACCAGATTGCAGAAAGTTTCTCCA

AAAAATATAAGTTTCCCTCTCGATCCTCAGGGATACTCTTGTATAATTTTGAG

C AATTGAAAAT GAACCTTGAT GAT AT AGTT AAAGAGGC AAAAAAT GT ACC AG

GTGTGACCCGTTTAGCCCATGACGGGTCCAAACTCCCCCTAAGATGTGTACTG

GGATGGGTCGCTTTGGCCAACTCTAAGAAATTCCAGTTGTTAGTCGAATCCGA

CAAGCTGAGTAAAATCATGCAAGATGACTTGAATCGCTATACATCTTGCTAA

CCGAACCTCTCCCCTCAGTCCCTCTAGACAATAAAATCCGAGATGTCCCAAAG

TCAACATGAAAAAAACAGGCAACACCACTGATAAAATGAACCTCCTACGTAA

GATAGTGAAAAACCGCAGGGACGAGGACACTCAAAAATCCTCTCCCGCGTCA

GCCCCTCTGGATGACGATGACTTGTGGCTTCCACCCCCTGAATACGTCCCGCT

GA A AGA ACTT AC AGGC A AG A AG A AC AT GAGGA AC TTTTGT AT C A AC GGA AG

GGTTAAAGTGTGTAGCCCGAATGGTTACTCGTTCAGGATCCTGCGGCACATTC

TGAAATCATTCGACGAGATATATTCTGGGAATCATAGGATGATCGGGTTAGTC

AAAGTGGTTATTGGACTGGCTTTGTCAGGATCTCCAGTCCCTGAGGGCCTGAA

CTGGGTATACAAATTGAGGAGAACCTTTATCTTCCAGTGGGCTGATTCCAGGG

GCCCTCTTGAAGGGGAGGAGTTGGAATACTCTCAGGAGATCACTTGGGATGA

T GAT AC T G AGTTCGTCGGATTGC A A AT A AGAGT GATT GC A A A AC AGT GT CAT

ATCC AGGGC AGAGTCTGGT GT AT C AAC AT GAACCCGAGAGC ATGT C AACT AT

GGTCTGACATGTCTCTTCAGACACAAAGGTCCGAAGAGGACAAAGATTCCTC

TCTGCTTCTAGAATAATCAGATTATATCCCGCAAATTTATCACTTGTTTACCTC

TGGAGGAGAGAACATATGGGCTCAACTCCAACCCTTGGGAGCAATATAACAA

AAAAC AT GTT ATGGT GCC ATT AAACCGCTGC ATTT CAT C AAAGTC AAGTT GAT

TACCTTTACATTTTGATCCTCTTGGATGTGAAAAAAACTATTAACATCCCTCA

AAAGACCccgggccaccATGTTCGTGTTTCTGGTGCTGCTGCCTCTGGTGAGCTCC

CAGTGCGTGAACTTCACCACAAGGACCCAGCTGCCCCCTGCCTATACCAATTC

CTTCACACGGGGCGTGTACTATCCCGACAAGGTGTTCCGGAGCAGCGTGCTG

CACTCCACACAGGATCTGTTTCTGCCTTTCTTTTCTAACGTGACCTGGTTCCAC

GCCATCCACGTGAGCGGCACCAATGGCACAAAGCGGTTCGCCAATCCAGTGC

TGCCCTTTAACGATGGCGTGTACTTCGCCTCCACCGAGAAGTCTAACATCATC

AGAGGCTGGATCTTTGGCACCACACTGGACAGCAAGACACAGTCCCTGCTGA

TCGT GAAC AAT GCC ACC AAC GT GGT CAT C AAGGT GTGCGAGTTCC AGTTTT GT AATGATCCATTCCTGGGCGTGTACTATCACAAGAACAATAAGTCTTGGATGG

AGAGCGAGTTTCGCGTGTATTCCTCTGCCAACAATTGCACATTTGAGTACGTG

TCCCAGCCCTTCCTGATGGACCTGGAGGGCAAGCAGGGCAATTTCAAGAACC

TGAGGGAGTTCGTGTTTAAGAATATCGATGGCTACTTCAAAATCTACTCCAAG

CACACCCCAATCAACCTGGTGCGCGGCCTGCCACAGGGCTTCTCTGCCCTGGA

GCCACTGGTGGATCTGCCCATCGGCATCAACATCACCCGGTTTCAGACACTGC

TGGCCCTGCACAGAAGCTACCTGACACCAGGCGACAGCTCCTCTGGATGGAC

CGCAGGAGCAGCAGCCTACTATGTGGGCTATCTGCAGCCCAGGACCTTCCTG

CTGAAGTACAACGAGAATGGCACCATCACAGACGCCGTGGATTGCGCCCTGG

ATCCCCTGTCTGAGACCAAGTGTACACTGAAGAGCTTTACCGTGGAGAAGGG

CATCTATCAGACAAGCAATTTCAGGGTGCAGCCTACCGAGTCCATCGTGCGCT

TTCCCAATATCACAAACCTGTGCCCTTTTGGCGAGGTGTTCAACGCAACCCGC

TTCGCCAGCGTGTACGCCTGGAATAGGAAGCGCATCTCCAACTGCGTGGCCG

ACTATTCTGTGCTGTACAACAGCGCCTCCTTCTCTACCTTTAAGTGCTATGGC

GTGAGCCCCACAAAGCTGAATGACCTGTGCTTTACCAACGTGTACGCCGATTC

CTTCGTGATCAGGGGCGACGAGGTGCGCCAGATCGCACCAGGACAGACAGGC

AATATCGCAGACTACAATTATAAGCTGCCTGACGATTTCACCGGCTGCGTGAT

CGCCTGGAACTCTAACAATCTGGATAGCAAAGTGGGCGGCAACTACAATTAT

CTGTACCGGCTGTTTAGAAAGTCTAATCTGAAGCCATTCGAGAGGGACATCTC

CACAGAAATCTACCAGGCCGGCTCTACCCCCTGCAATGGCGTGAAGGGCTTT

AACTGTTATTTCCCTCTGCAGAGCTACGGCTTCCAGCCAACATATGGCGTGGG

CTATCAGCCCTACCGCGTGGTGGTGCTGTCTTTTGAGCTGCTGCACGCACCTG

C A AC AGT GT GC GGACC A A AGA AGAGC AC C A ATCTGGT GA AGA AC A AGT GC G

TGAACTTCAACTTCAACGGACTGACCGGAACAGGCGTGCTGACCGAGTCCAA

CAAGAAGTTCCTGCCTTTTCAGCAGTTCGGCAGGGACATCGCAGATACCACA

GACGCCGTGCGCGACCCTCAGACCCTGGAGATCCTGGACATCACACCATGCT

CCTTCGGCGGCGTGTCTGTGATCACACCAGGCACCAATACAAGCAACCAGGT

GGCCGT GCTGT AT C AGGGCGT GAATT GT ACCGAGGTGCC AGT GGC AATCC AC

GCAGATCAGCTGACCCCTACATGGCGGGTGTACTCTACCGGCAGCAACGTGT

TCCAGACAAGAGCCGGATGCCTGATCGGAGCAGAGCACGTGAACAATAGCTA

TGAGTGCGACATCCCTATCGGCGCCGGCATCTGTGCCTCCTACCAGACCCAGA

CAAACTCCCCAGAATCAAGCGTGATTCCTCTGGTCCATCCACTGGCAGATCCC

TCCACAGTGTTCAAAGACGGAGATGAGGCCGAAGACTTTGTGGAAGTCCACC

TGCCTGATGTGCATAACCAGGTGTCTGGCGTCGACCTGGGACTGCCAAATTG GGGCAAGTACGTGCTGCTGAGTGCTGGAGCACTGACTGCCCTGATGCTGATC

ATTTTCCTGATGACCTGCTGTCGGCGCGTGAACAGAAGTGAGCCCACTCAGC

AC AATCTGCGAGGAACCGGGAGAGAAGT GTC AGT C AC ACCTC AGAGCGGGA

AAAT C ATT AGT AGTTGGGAAT C AC AT AAAAGCGGGGGCGAGACC AGGCTGgg atccggctccggcgagggcaggggaagtctactaacatgcggggacgtggaggaaaatcccggccccATGGTTCCT

CAGGCTCTCCTGTTTGTACCCCTTCTGGTTTTTCCATTGTGTTTTGGGAAATTC

CCTATTTACACGATACCAGACAAGCTTGGTCCCTGGAGTCCGATTGACATACA

TCACCTCAGCTGCCCAAACAATTTGGTAGTGGAGGACGAAGGATGCACCAAC

CTGTCAGGGTTCTCCTACATGGAACTTAAAGTTGGATACATCTTAGCCATAAA

AGTGAACGGGTTCACTTGCACAGGCGTTGTGACGGAGGCTGAAACCTACACT

AACTTCGTTGGTTATGTCACAACCACGTTCAAAAGAAAGCATTTCCGCCCAAC

ACCAGATGCATGTAGAGCCGCGTACAACTGGAAGATGGCCGGTGACCCCAGA

TATGAAGAGTCTCTACACAATCCGTACCCTGACTACCGCTGGCTTCGAACTGT

AAAAACCACCAAGGAGTCTCTCGTTATCATATCTCCAAGTGTGGCAGATTTGG

ACCCATATGACAGATCCCTTCACTCGAGGGTCTTCCCTAGCGGGAAGTGCTCA

GGAGTAGCGGTGTCTTCTACCTACTGCTCCACTAACCACGATTACACCATTTG

GATGCCCGAGAATCCGAGACTAGGGATGTCTTGTGACATTTTTACCAATAGTA

GAGGGAAGAGAGC ATCC AAAGGGAGT GAGACTT GCGGCTTT GT AGATGAAA

G AGGC C T AT AT A AGT C T TT A A A AGG AGC AT GCA A AC T C A AGTT AT GT GG AGT

TCTAGGACTTAGACTTATGGATGGAACATGGGTCTCGATGCAAACATCAAAT

GAAACCAAATGGTGCCCTCCCGATAAGTTGGTGAACCTGCACGACTTTCGCTC

AGACGAAATTGAGCACCTTGTTGTAGAGGAGTTGGTCAGGAAGAGAGAGGA

GTGTCTGGATGCACTAGAGTCCATCATGACAACCAAGTCAGTGAGTTTCAGA

CGTCTCAGTCATTTAAGAAAACTTGTCCCTGGGTTTGGAAAAGCATATACCAT

ATTCAACAAGACCTTGATGGAAGCCGATGCTCACTACAAGTCAGTCgagACTT

GGAAT GAGATCCTCCCTT C AAAAGGGT GTTT A AGAGTT GGGGGGAGGTGT C A

TCCTC AT GTGAACGGGGT GTTTTT C AAT GGT AT AAT ATT AGGACCTGACGGC A

ATGTCTTAATCCCAGAGATGCAATCATCCCTCCTCCAGCAACATATGGAGTTG

TTGGAATCCTCGGTTATCCCCCTTGTGCACCCCCTGGCAGACCCGTCTACCGT

TTTCAAGGACGGTGACGAGGCTGAGGATTTTGTTGAAGTTCACCTTCCCGATG

TGCACAATCAGGTCTCAGGAGTTGACTTGGGTCTCCCGAACTGGGGGAAGTA

TGTATTACTGAGTGCAGGGGCCCTGACTGCCTTGATGTTGATAATTTTCCTGA

TGACATGTTGTAGAAGAGTCAATCGATCAGAACCTACGCAACACAATCTCAG

AGGGACAGGGAGGGAGGTGTCAGTCACTCCCCAAAGCGGGAAGATCATATCT T CAT GGGAATC AC AC AAGAGT GGGGGT GAGACC AGACTGT AAgctagcTT AT A A

AGTGCTGGGTCATCTAAGCTTTTCAGTCGAGAAAAAAACATTAGATCAGAAG

AACAACTGGCAACACTTCTCAACCTGAGACTTACTTCAAGATGCTCGATCCTG

GAGAGGTCTATGATGACCCTATTGACCCAATCGAGTTAGAGGCTGAACCCAG

AGGAACCCCCATTGTCCCCAACATCTTGAGGAACTCTGACTACAATCTCAACT

CTCCTTTGATAGAAGATCCTGCTAGACTAATGTTAGAATGGTTAAAAACAGG

GAATAGACCTTATCGGATGACTCTAACAGACAATTGCTCCAGGTCTTTCAGAG

TTTTGAAAGATTATTTCAAGAAGGTAGATTTGGGTTCTCTCAAGGTGGGCGGA

ATGGCTGCACAGTCAATGATTTCTCTCTGGTTATATGGTGCCCACTCTGAATC

CAACAGGAGCCGGAGATGTATAACAGACTTGGCCCATTTCTATTCCAAGTCG

TCCCCCATAGAGAAGCTGTTGAATCTCACGCTAGGAAATAGAGGGCTGAGAA

TCCCCCCAGAGGGAGTGTTAAGTTGCCTTGAGAGGGTTGATTATGATAATGC

ATTTGGAAGGTATCTTGCCAACACGTATTCCTCTTACTTGTTCTTCCATGTAAT

CACCTTATACATGAACGCCCTAGACTGGGATGAAGAAAAGACCATCCTAGCA

TTATGGAAAGATTTAACCTCAGTGGACATCGGGAAGGACTTGGTAAAGTTCA

AAGACCAAATATGGGGACTGCTGATCGTGACAAAGGACTTTGTTTACTCCCA

AAGTTCCAATTGTCTTTTTGACAGAAACTACACACTTATGCTAAAAGATCTTT

TCTTGTCTCGCTTCAACTCCTTAATGGTCTTGCTCTCTCCCCCAGAGCCCCGAT

ACTCAGATGACTTGATATCTCAACTATGCCAGCTGTACATTGCTGGGGATCAA

GTCTTGTCTATGTGTGGAAACTCCGGCTATGAAGTCATCAAAATATTGGAGCC

ATATGTCGTGAATAGTTTAGTCCAGAGAGCAGAAAAGTTTAGGCCTCTCATTC

ATTCCTTGGGAGACTTTCCTGTATTTATAAAAGACAAGGTAAGTCAACTTGAA

GAGACGTTCGGTCCCTGTGCAAGAAGGTTCTTTAGGGCTCTGGATCAATTCGA

CAACATACATGACTTGGTTTTTGTGTTTGGCTGTTACAGGCATTGGGGGCACC

CATATATAGATTATCGAAAGGGTCTGTCAAAACTATATGATCAGGTTCACCTT

A A A A A A AT GAT AG AT A AGTCC T AC C AGGAGT GC TT AGC A AGCGAC CT AGCC A

GGAGGATCCTTAGATGGGGTTTTGATAAGTACTCCAAGTGGTATCTGGATTCA

AGATTCCTAGCCCGAGACCACCCCTTGACTCCTTATATCAAAACCCAAACATG

GCCACCCAAACATATTGTAGACTTGGTGGGGGATACATGGCACAAGCTCCCG

ATCACGCAGATCTTTGAGATTCCTGAATCAATGGATCCGTCAGAAATATTGGA

TGACAAATCACATTCTTTCACCAGAACGAGACTAGCTTCTTGGCTGTCAGAAA

ACCGAGGGGGGCCTGTTCCTAGCGAAAAAGTTATTATCACGGCCCTGTCTAA

GCCGCCTGTCAATCCCCGAGAGTTTCTGAGGTCTATAGACCTCGGAGGATTGC

C AGAT GA AGAC TT GAT A ATT GGCC T C A AGCC A A AGGA AC GGGA ATTGA AGAT TGAAGGTCGATTCTTTGCTCTAATGTCATGGAATCTAAGATTGTATTTTGTCAT

CACTGAAAAACTCTTGGCCAACTACATCTTGCCACTTTTTGACGCGCTGACTA

T GAC AGAC AACCTGAAC AAGGT GTTT AAAAAGCTGATCGAC AGGGT C ACCGG

GCAAGGGCTTTTGGACTATTCAAGGGTCACATATGCATTTCACCTGGACTATG

AAAAGTGGAACAACCATCAAAGATTAGAGTCAACAGAGGATGTATTTTCTGT

CCTAGATCAAGTGTTTGGATTGAAGAGAGTGTTTTCTAGAACACACGAGTTTT

TTCAAAAGGCCTGGATCTATTATTCAGACAGATCAGACCTCATCGGGTTACGG

GAGGATCAAATATACTGCTTAGATGCGTCCAACGGCCCAACCTGTTGGAATG

GCC AGGAT GGCGGGCT AGAAGGCTT ACGGC AGAAGGGCTGGAGTCT AGT C A

GCTT ATT GAT GAT AG AT AGAGAATCTC AAATC AGGAAC AC AAGAACC AAAAT

ACTAGCTCAAGGAGACAACCAGGTTTTATGTCCGACATACATGTTGTCGCCA

GGGC T AT C T C A AG AGGGGC TCCTCTAT G A ATT GG AG AG A AT AT C A AGG A AT G

CACTTTCGATATACAGAGCCGTCGAGGAAGGGGCATCTAAGCTAGGGCTGAT

CAT C A AG A A AG A AG AG AC CAT GT GT AGTT AT GAC TTCCTC ATCT AT GGA A A A

ACCCCTTTGTTTAGAGGTAACATATTGGTGCCTGAGTCCAAAAGATGGGCCA

GAGTCTCTTGCGTCTCTAATGACCAAATAGTCAACCTCGCCAATATAATGTCG

ACAGTGTCCACCAATGCGCTAACAGTGGCACAACACTCTCAATCTTTGATCAA

ACCGATGAGGGATTTTCTGCTCATGTCAGTACAGGCAGTCTTTCACTACCTGC

TATTTAGCCCAATCTTAAAGGGAAGAGTTTACAAGATTCTGAGCGCTGAAGG

GGAGAGCTTTCTCCTAGCCATGTCAAGGATAATCTATCTAGATCCTTCTTTGG

GAGGGAT ATCTGGAATGTCCCTCGGAAGATTCC AT AT ACGAC AGTTCTC AGA

CCCTGTCTCTGAAGGGTTATCCTTCTGGAGAGAGATCTGGTTAAGCTCCCAAG

AGTCCTGGATTCACGCGTTGTGTCAAGAGGCTGGAAACCCAGATCTTGGAGA

GAGAACACTCGAGAGCTTCACTCGCCTTCTAGAAGATCCGACCACCTTAAAT

AT C AG AGG AGGGGC C AGTCC T AC C ATTCT ACTC A AGGAT GCA AT C AGA A AGG

CTTT AT ATGACGAGGT GG AC AAGGT GGAAAATTC AGAGTTTCGAGAGGC AAT

CCTGTTGTCCAAGACCCATAGAGATAATTTTATACTCTTCTTAATATCTGTTGA

GCCTCTGTTTCCTCGATTTCTCAGTGAGCTATTCAGTTCGTCTTTTTTGGGAAT

CCCCGAGTCAATCATTGGATTGATACAAAACTCCCGAACGATAAGAAGGCAG

TTT AGAAAGAGTCTCTC AAAAACTTT AGAAGAATCCTTCT AC AACTC AGAGAT

CC ACGGGATT AGTCGGATGACCC AGAC ACCTC AGAGGGTT GGGGGGGT GT GG

CCTTGCTCTTCAGAGAGGGCAGATCTACTTAGGGAGATCTCTTGGGGAAGAA

AAGTGGTAGGCACGACAGTTCCTCACCCTTCTGAGATGTTGGGATTACTTCCC

AAGTCCTCTATTTCTTGCACTTGTGGAGCAACAGGAGGAGGCAATCCTAGAG TTTCTGTATCAGTACTCCCGTCCTTTGATCAGTCATTTTTTTCACGAGGCCCCC

TAAAGGGATACTTGGGCTCGTCCACCTCTATGTCGACCCAGCTATTCCATGCA

T GGG A A A A AGT C AC T A AT GT TC AT GT GGT G A AG AG AGC TC T AT C GT T A A A AG

AATCTATAAACTGGTTCATTACTAGAGATTCCAACTTGGCTCAAGCTCTAATT

AGGAACATTATGTCTCTGACAGGCCCTGATTTCCCTCTAGAGGAGGCCCCTGT

CTTCAAAAGGACGGGGTCAGCCTTGCATAGGTTCAAGTCTGCCAGATACAGC

GAAGGAGGGTATTCTTCTGTCTGCCCGAACCTCCTCTCTCATATTTCTGTTAGT

ACAGACACCATGTCTGATTTGACCCAAGACGGGAAGAACTACGATTTCATGT

TCC AGCC ATTGAT GCTTT AT GC AC AG AC AT GGAC ATC AGAGCTGGT AC AG AG

AGACACAAGGCTAAGAGACTCTACGTTTCATTGGCACCTCCGATGCAACAGG

TGTGTGAGACCCATTGACGACGTGACCCTGGAGACCTCTCAGATCTTCGAGTT

TCCGGATGTGTCGAAAAGAATATCCAGAATGGTTTCTGGGGCTGTGCCTCACT

TCCAGAGGCTTCCCGATATCCGTCTGAGACCAGGAGATTTTGAATCTCTAAGC

GGTAGAGAAAAGTCTCACCATATCGGATCAGCTCAGGGGCTCTTATACTCAA

TCTTAGTGGCAATTCACGACTCAGGATACAATGATGGAACCATCTTCCCTGTC

AACATATACGGCAAGGTTTCCCCTAGAGACTATTTGAGAGGGCTCGCAAGGG

GAGT ATT GAT AGGATCCTCGATTT GCTTCTT GAC AAGAATGAC AAAT ATC AAT

ATTAATAGACCTCTTGAATTGGTCTCAGGGGTAATCTCATATATTCTCCTGAG

GCTAGATAACCATCCCTCCTTGTACATAATGCTCAGAGAACCGTCTCTTAGAG

GAGAGATATTTTCTATCCCTCAGAAAATCCCCGCCGCTTATCCAACCACTATG

AAAGAAGGCAACAGATCAATCTTGTGTTATCTCCAACATGTGCTACGCTATG

AGCGAGAGATAATCACGGCGTCTCCAGAGAATGACTGGCTATGGATCTTTTC

AGACTTTAGAAGTGCCAAAATGACGTACCTATCCCTCATTACTTACCAGTCTC

ATCTTCTACTCCAGAGGGTTGAGAGAAACCTATCTAAGAGTATGAGAGATAA

CCTGCGACAATTGAGTTCTTTGATGAGGCAGGTGCTGGGCGGGCACGGAGAA

GATACCTTAGAGTCAGACGACAACATTCAACGACTGCTAAAAGACTCTTTAC

GAAGGAC AAGAT GGGTGGATC AAGAGGT GCGCC AT GC AGCT AGAACC AT GA

CTGGAGATTACAGCCCCAACAAGAAGGTGTCCCGTAAGGTAGGATGTTCAGA

ATGGGTCTGCTCTGCTCAACAGGTTGCAGTCTCTACCTCAGCAAACCCGGCCC

CTGTCTCGGAGCTTGACATAAGGGCCCTCTCTAAGAGGTTCCAGAACCCTTTG

ATCTCGGGCTTGAGAGTGGTTC AGT GGGC AACCGGT GCTC ATT AT AAGCTT AA

GCCTATTCTAGATGATCTCAATGTTTTCCCATCTCTCTGCCTTGTAGTTGGGGA

CGGGTCAGGGGGGATATCAAGGGCAGTCCTCAACATGTTTCCAGATGCCAAG

CTTGTGTTCAACAGTCTTTTAGAGGTGAATGACCTGATGGCTTCCGGAACACA TCCACTGCCTCCTTCAGCAATCATGAGGGGAGGAAATGATATCGTCTCCAGA

GTGATAGATCTTGACTCAATCTGGGAAAAACCGTCCGACTTGAGAAACTTGG

CAACCTGGAAATACTTCCAGTCAGTCCAAAAGCAGGTCAACATGTCCTATGA

CCTCATTATTTGCGATGCAGAAGTTACTGACATTGCATCTATCAACCGGATCA

CCCTGTTAATGTCCGATTTTGCATTGTCTATAGATGGACCACTCTATTTGGTCT

T C A A A AC TT AT GGGAC T AT GCT AGT A A ATCC A A ACT AC A AGGC T ATTC A AC A

CCTGTCAAGAGCGTTCCCCTCGGTCACAGGGTTTATCACCCAAGTAACTTCGT

CTTTTTCATCTGAGCTCTACCTCCGATTCTCCAAACGAGGGAAGTTTTTCAGA

GATGCTGAGTACTTGACCTCTTCCACCCTTCGAGAAATGAGCCTTGTGTTATT

CAATTGTAGCAGCCCCAAGAGTGAGATGCAGAGAGCTCGTTCCTTGAACTAT

C AGGATCTT GTGAGAGGATTTCCTGAAGAAAT CAT AT C AAATCCTT AC AAT G

AGATGATCATAACTCTGATTGACAGTGATGTAGAATCTTTTCTAGTCCACAAG

AT GGTT GAT GAT C TT GAGTT AC AGAGGGGA AC TC T GTCT A A AGT GGCT AT CAT

TATAGCCATCATGATAGTTTTCTCCAACAGAGTCTTCAACGTTTCCAAACCCC

TAACTGACCCCTCGTTCTATCCACCGTCTGATCCCAAAATCCTGAGGCACTTC

AACATATGTTGCAGTACTATGATGTATCTATCTACTGCTTTAGGTGACGTCCC

TAGCTTCGCAAGACTTCACGACCTGTATAACAGACCTATAACTTATTACTTCA

GAAAGCAAGTCATTCGAGGGAACGTTTATCTATCTTGGAGTTGGTCCAACGA

CACCTCAGTGTTCAAAAGGGTAGCCTGTAATTCTAGCCTGAGTCTGTCATCTC

ACTGGAT C AGGTTGATTT AC AAGAT AGT GAAGACT ACC AGACTCGTT GGC AG

CATCAAGGATCTATCCAGAGAAGTGGAAAGACACCTTCATAGGTACAACAGG

TGGATCACCCTAGAGGATATCAGATCTAGATCATCCCTACTAGACTACAGTTG

CCTGTGAACCGGATACTCCTGGAAGCCTGCCCATGCTAAGACTCTTGTGTGAT

GTATCTTGAAAAAAACAAGATCCTAAATCTGAACCTTTGGTTGTTTGATTGTT

TTTCTCATTTTTGTTGTTTATTTGTTAAGCGT.

In one embodiment, the nucleic acid comprises the sequence of SEQ ID NO: 16, shown below (RABV vector: Coravax V6 China):

ACGCTTAACAACCAGATCAAAGAAAAAACAGACATTGTCAATTGCAAAGCAA

AAATGTAACACCCCTACAATGGATGCCGACAAGATTGTATTCAAAGTCAATA

AT C AGGT GGT C TC TT T G A AGC C T GAG AT T AT C GT GG AT C A AT AT G AGT AC A AG

TACCCTGCCATCAAAGATTTGAAAAAGCCCTGTATAACCCTAGGAAAGGCTC

CCGATTTAAATAAAGCATACAAGTCAGTTTTGTCAGGCATGAGCGCCGCCAA

ACTTAATCCTGACGATGTATGTTCCTATTTGGCAGCGGCAATGCAGTTTTTTG

AGGGGACATGTCCGGAAGACTGGACCAGCTATGGAATTGTGATTGCACGAAA AGGAGATAAGATCACCCCAGGTTCTCTGGTGGAGATAAAACGTACTGATGTA

GAAGGGAATT GGGCTCTGAC AGGAGGC AT GGAACTGAC AAGAGACCCC ACT

GTCCCTGAGCATGCGTCCTTAGTCGGTCTTCTCTTGAGTCTGTATAGGTTGAG

CAAAATATCCGGGCAAAACACTGGTAACTATAAGACAAACATTGCAGACAGG

ATAGAGCAGATTTTTGAGACAGCCCCTTTTGTTAAAATCGTGGAACACCATAC

TCTAATGACAACTCACAAAATGTGTGCTAATTGGAGTACTATACCAAACTTCA

GATTTTTGGCCGGAACCTATGACATGTTTTTCTCCCGGATTGAGCATCTATATT

CAGCAATCAGAGTGGGCACAGTTGTCACTGCTTATGAAGACTGTTCAGGACT

GGTATCATTTACTGGGTTCATAAAACAAATCAATCTCACCGCTAGAGAGGCA

ATACTATATTTCTTCCACAAGAACTTTGAGGAAGAGATAAGAAGAATGTTTG

AGCCAGGGCAGGAGACAGCTGTTCCTCACTCTTATTTCATCCACTTCCGTTCA

CTAGGCTTGAGTGGGAAATCTCCTTATTCATCAAATGCTGTTGGTCACGTGTT

CAATCTCATTCACTTTGTAGGATGCTATATGGGTCAAGTCAGATCCCTAAATG

CAACGGTTATTGCTGCATGTGCTCCTCATGAAATGTCTGTTCTAGGGGGCTAT

CTGGGAGAGGAATTCTTCGGGAAAGGGAC ATTTGAAAGAAGATTCTTC AGAG

AT GAG A A AG A AC TT C A AG A AT AC G AGGC GGC T G A AC T G AC A A AG AC T G AC G

TAGCACTGGCAGATGATGGAACTGTCAACTCTGACGACGAGGACTACTTTTC

AGGT GAAACC AGAAGTCCGGAGGCTGTTT AT ACTCGAAT CAT GAT GAAT GGA

GGTCGACTAAAGAGATCTCACATACGGAGATATGTCTCAGTCAGTTCCAATC

ATCAAGCCCGTCCAAACTCATTCGCCGAGTTTCTAAACAAGACATATTCGAGT

GACTCATAAGAAGTTGAATAACAAAATGCCGGAAATCTACGGATTGTGTATA

TCCATCATGAAAAAAACTAACACCCCTCCTTTCGAACCATCCCAAACATGAG

CAAGATCTTTGTCAATCCTAGTGCTATTAGAGCCGGTCTGGCCGATCTTGAGA

T GGCTGAAGAAACTGTTGATCTGAT C AAT AGAAAT ATCGAAGAC AAT C AGGC

TCATCTCCAAGGGGAACCCATAGAGGTGGACAATCTCCCTGAGGATATGGGG

CGACTTCACCTGGATGATGGAAAATCGCCCAACCATGGTGAGATAGCCAAGG

T GGG AG A AGGC A AGT ATC G AG AGG AC T T T C AG AT GG AT G A AGG AG AGG AT C

CTAGCTTCCTGTTCCAGTCATACCTGGAAAATGTTGGAGTCCAAATAGTCAGA

CAAATGAGGTCAGGAGAGAGATTTCTCAAGATATGGTCACAGACCGTAGAAG

AGATTATATCCTATGTCGCGGTCAACTTTCCCAACCCTCCAGGAAAGTCTTCA

GAGGATAAATCAACCCAGACTACTGGCCGAGAGCTCAAGAAGGAGACAACA

CCCACTCCTTCTCAGAGAGAAAGCCAATCATCGAAAGCCAGGATGGCGGCTC

AAATTGCTTCTGGCCCTCCAGCCCTTGAATGGTCGGCTACCAATGAAGAGGAT

GATCTATCAGTGGAGGCTGAGATCGCTCACCAGATTGCAGAAAGTTTCTCCA AAAAATATAAGTTTCCCTCTCGATCCTCAGGGATACTCTTGTATAATTTTGAG

C AATTGAAAAT GAACCTTGATGAT AT AGTT AAAGAGGC AAAAAAT GT ACC AG

GTGTGACCCGTTTAGCCCATGACGGGTCCAAACTCCCCCTAAGATGTGTACTG

GGATGGGTCGCTTTGGCCAACTCTAAGAAATTCCAGTTGTTAGTCGAATCCGA

CAAGCTGAGTAAAATCATGCAAGATGACTTGAATCGCTATACATCTTGCTAA

CCGAACCTCTCCCCTCAGTCCCTCTAGACAATAAAATCCGAGATGTCCCAAAG

TCAACATGAAAAAAACAGGCAACACCACTGATAAAATGAACCTCCTACGTAA

GATAGTGAAAAACCGCAGGGACGAGGACACTCAAAAATCCTCTCCCGCGTCA

GCCCCTCTGGATGACGATGACTTGTGGCTTCCACCCCCTGAATACGTCCCGCT

GA A AGA ACTT AC AGGC A AG A AG A AC AT GAGGA AC TTTTGT AT C A AC GGA AG

GGTTAAAGTGTGTAGCCCGAATGGTTACTCGTTCAGGATCCTGCGGCACATTC

TGAAATCATTCGACGAGATATATTCTGGGAATCATAGGATGATCGGGTTAGTC

AAAGTGGTTATTGGACTGGCTTTGTCAGGATCTCCAGTCCCTGAGGGCCTGAA

CTGGGTATACAAATTGAGGAGAACCTTTATCTTCCAGTGGGCTGATTCCAGGG

GCCCTCTTGAAGGGGAGGAGTTGGAATACTCTCAGGAGATCACTTGGGATGA

T GAT AC T G AGTTCGTCGGATTGC A A AT A AGAGT GATT GC A A A AC AGT GT CAT

ATCC AGGGC AGAGTCTGGT GT AT C AAC AT GAACCCGAGAGC ATGT C AACT AT

GGTCTGACATGTCTCTTCAGACACAAAGGTCCGAAGAGGACAAAGATTCCTC

TCTGCTTCTAGAATAATCAGATTATATCCCGCAAATTTATCACTTGTTTACCTC

TGGAGGAGAGAACATATGGGCTCAACTCCAACCCTTGGGAGCAATATAACAA

AAAAC AT GTT ATGGT GCC ATT AAACCGCTGC ATTT CAT C AAAGTC AAGTT GAT

TACCTTTACATTTTGATCCTCTTGGATGTGAAAAAAACTATTAACATCCCTCA

AAAGACCccgggAAAGATGGTTCCTCAGGCTCTCCTGTTTGTACCCCTTCTGGTT

TTTCCATTGTGTTTTGGGAAATTCCCTATTTACACGATACCAGACAAGCTTGG

TCCCTGGAGTCCGATTGACATACATCACCTCAGCTGCCCAAACAATTTGGTAG

TGGAGGACGAAGGATGCACCAACCTGTCAGGGTTCTCCTACATGGAACTTAA

AGTTGGATACATCTTAGCCATAAAAGTGAACGGGTTCACTTGCACAGGCGTT

GTGACGGAGGCTGAAACCTACACTAACTTCGTTGGTTATGTCACAACCACGTT

CAAAAGAAAGCATTTCCGCCC AAC ACCAGATGC ATGT AGAGCCGCGTAC AAC

TGGAAGATGGCCGGTGACCCCAGATATGAAGAGTCTCTACACAATCCGTACC

CTGACTACCGCTGGCTTCGAACTGTAAAAACCACCAAGGAGTCTCTCGTTATC

ATATCTCCAAGTGTGGCAGATTTGGACCCATATGACAGATCCCTTCACTCGAG

GGTCTTCCCTAGCGGGAAGTGCTCAGGAGTAGCGGTGTCTTCTACCTACTGCT

CCACTAACCACGATTACACCATTTGGATGCCCGAGAATCCGAGACTAGGGAT GTCTTGTGACATTTTTACCAATAGTAGAGGGAAGAGAGCATCCAAAGGGAGT

GAGACTTGCGGCTTTGT AG AT GAAAGAGGCCT AT AT AAGTCTTT AAAAGGAG

CAT GC A A ACTC A AGTT AT GT GGAGTTC T AGGAC TT AG AC TT AT GGAT GGA AC

ATGGGTCTCGATGCAAACATCAAATGAAACCAAATGGTGCCCTCCCGATAAG

TTGGTGAACCTGCACGACTTTCGCTCAGACGAAATTGAGCACCTTGTTGTAGA

GGAGTTGGTCAGGAAGAGAGAGGAGTGTCTGGATGCACTAGAGTCCATCATG

AC A AC C A AGT C AGT GAGTTT C AGAC GTCTC AGT C ATTT A AGA A A AC TT GT C CC

T GGGTTTGGAAAAGC AT AT ACC AT ATTC AAC AAGACCTTGAT GGAAGCCGAT

GCTCACTACAAGTCAGTCgagACTTGGAATGAGATCCTCCCTTCAAAAGGGTG

TTTAAGAGTTGGGGGGAGGTGTCATCCTCATGTGAACGGGGTGTTTTTCAATG

GTATAATATTAGGACCTGACGGCAATGTCTTAATCCCAGAGATGCAATCATCC

CTCCTCCAGCAACATATGGAGTTGTTGGAATCCTCGGTTATCCCCCTTGTGCA

CCCCCTGGCAGACCCGTCTACCGTTTTCAAGGACGGTGACGAGGCTGAGGAT

TTTGTTGAAGTTCACCTTCCCGATGTGCACAATCAGGTCTCAGGAGTTGACTT

GGGTCTCCCGAACTGGGGGAAGT AT GT ATT ACTGAGTGC AGGGGCCCTGACT

GCCTT GATGTT GAT AATTTTCCTGAT GAC AT GTTGT AGAAGAGT C AATCGAT C

AGAACCTACGCAACACAATCTCAGAGGGACAGGGAGGGAGGTGTCAGTCAC

T C CC C A A AGC GGGA AGAT CAT ATCTTC AT GGGA AT C AC AC A AG AGT GGGGGT

GAG AC C AGAC T GT A AttaattaaC GT C CTTT C A AC GAT C C A AGTCcatgaaaaaaactaacac ccctcccgtacgaccATGTTCGTGTTTCTGGTGCTGCTGCCTCTGGTGAGCTCCCAGTG

CGTGAACCTGACCACAAGGACCCAGCTGCCCCCTGCCTATACCAATTCCTTCA

CACGGGGCGTGTACTATCCCGACAAGGTGTTCCGGAGCAGCGTGCTGCACTC

CACACAGGATCTGTTTCTGCCTTTCTTTTCTAACGTGACCTGGTTCCACGCCAT

CCACGTGAGCGGCACCAATGGCACAAAGCGGTTCGACAATCCAGTGCTGCCC

TTTAACGATGGCGTGTACTTCGCCTCCACCGAGAAGTCTAACATCATCAGAGG

CTGGATCTTTGGCACCACACTGGACAGCAAGACACAGTCCCTGCTGATCGTG

AACAATGCCACCAACGTGGTCATCAAGGTGTGCGAGTTCCAGTTTTGTAATG

ATCCATTCCTGGGCGTGTACTATCACAAGAACAATAAGTCTTGGATGGAGAG

CGAGTTTCGCGTGTATTCCTCTGCCAACAATTGCACATTTGAGTACGTGTCCC

AGCCCTTCCTGATGGACCTGGAGGGCAAGCAGGGCAATTTCAAGAACCTGAG

GGAGTTCGTGTTTAAGAATATCGATGGCTACTTCAAAATCTACTCCAAGCACA

CCCCAATCAACCTGGTGCGCGACCTGCCACAGGGCTTCTCTGCCCTGGAGCCA

CTGGTGGATCTGCCCATCGGCATCAACATCACCCGGTTTCAGACACTGCTGGC

CCTGCACAGAAGCTACCTGACACCAGGCGACAGCTCCTCTGGATGGACCGCA GGAGCAGCAGCCTACTATGTGGGCTATCTGCAGCCCAGGACCTTCCTGCTGA

AGTACAACGAGAATGGCACCATCACAGACGCCGTGGATTGCGCCCTGGATCC

CCTGTCTGAGACCAAGTGTACACTGAAGAGCTTTACCGTGGAGAAGGGCATC

TATCAGACAAGCAATTTCAGGGTGCAGCCTACCGAGTCCATCGTGCGCTTTCC

CAATATCACAAACCTGTGCCCTTTTGGCGAGGTGTTCAACGCAACCCGCTTCG

CCAGCGTGTACGCCTGGAATAGGAAGCGCATCTCCAACTGCGTGGCCGACTA

TTCTGTGCTGTACAACAGCGCCTCCTTCTCTACCTTTAAGTGCTATGGCGTGA

GCCCCACAAAGCTGAATGACCTGTGCTTTACCAACGTGTACGCCGATTCCTTC

GTGATCAGGGGCGACGAGGTGCGCCAGATCGCACCAGGACAGACAGGCAAG

ATCGCAGACTACAATTATAAGCTGCCTGACGATTTCACCGGCTGCGTGATCGC

CTGGAACTCTAACAATCTGGATAGCAAAGTGGGCGGCAACTACAATTATCTG

TACCGGCTGTTTAGAAAGTCTAATCTGAAGCCATTCGAGAGGGACATCTCCA

CAGAAATCTACCAGGCCGGCTCTACCCCCTGCAATGGCGTGGAgGGCTTTAAC

TGTTATTTCCCTCTGCAGAgCTACgGCTTCCAGCCAACAAACGGCGTGGGCTA

TCAGCCCTACCGCGTGGTGGTGCTGTCTTTTGAGCTGCTGCACGCACcTGCAA

C AGT GT GCGGACC AA AGAAGAGC ACC AATCTGGTGAAGAAC AAGT GCGT GA

ACTTCAACTTCAACGGACTGACCGGAACAGGCGTGCTGACCGAGTCCAACAA

GAAGTTCCTGCCTTTTCAGCAGTTCGGCAGGGACATCGCAGATACCACAGAC

GCCGTGCGCGACCCTCAGACCCTGGAGATCCTGGACATCACACCATGCTCCTT

CGGCGGCGTGTCTGTGATCACACCAGGCACCAATACAAGCAACCAGGTGGCC

GTGCTGTATCAGGACGTGAATTGTACCGAGGTGCCAGTGGCAATCCACGCAG

ATCAGCTGACCCCTACATGGCGGGTGTACTCTACCGGCAGCAACGTGTTCCA

GACAAGAGCCGGATGCCTGATCGGAGCAGAGCACGTGAACAATAGCTATGA

GTGCGACATCCCTATCGGCGCCGGCATCTGTGCCTCCTACCAGACCCAGACA

AACTCCCCAAGGTCTGTGGGAGATGAGGCCGAAGACTTTGTGGAAGTCCACC

TGCCTGATGTGCATAACCAGGTGTCTGGCGTCGACCTGGGACTGCCAAATTG

GGGCAAGTACGTGCTGCTGAGTGCTGGAGCACTGACTGCCCTGATGCTGATC

ATTTTCCTGATGACCTGCTGTCGGCGCGTGAACAGAAGTGAGCCCACTCAGC

AC AATCTGCGAGGAACCGGGAGAGAAGT GTC AGT C AC ACCTC AGAGCGGGA

AAAT C ATT AGT AGTTGGGAAT C AC AT AAAAGCGGGGGCGAGACC AGGCTGgg atccggctccggcgagggcaggggaagtctactaacatgcggggacgtggaggaaaatcccggccccATGCTCGAT

CCTGGAGAGGTCTATGATGACCCTATTGACCCAATCGAGTTAGAGGCTGAAC

CCAGAGGAACCCCCATTGTCCCCAACATCTTGAGGAACTCTGACTACAATCTC

AACTCTCCTTTGATAGAAGATCCTGCTAGACTAATGTTAGAATGGTTAAAAAC AGGGAATAGACCTTATCGGATGACTCTAACAGACAATTGCTCCAGGTCTTTCA

GAGTTTTGAAAGATT ATTT C AAGAAGGT AGATTTGGGTTCTCTC AAGGT GGGC

GGAATGGCTGCACAGTCAATGATTTCTCTCTGGTTATATGGTGCCCACTCTGA

ATCCAACAGGAGCCGGAGATGTATAACAGACTTGGCCCATTTCTATTCCAAG

TCGTCCCCCATAGAGAAGCTGTTGAATCTCACGCTAGGAAATAGAGGGCTGA

GAATCCCCCCAGAGGGAGTGTTAAGTTGCCTTGAGAGGGTTGATTATGATAA

TGCATTTGG AAGGT ATCTTGCCAACACGTATTCCTCTTACTTGTTCTTCCATGT

AATCACCTTATACATGAACGCCCTAGACTGGGATGAAGAAAAGACCATCCTA

GC ATT ATGGA AAGATTT AACCTC AGT GGAC ATCGGGAAGGACTT GGT AAAGT

T C AAAGACC AAAT AT GGGGACTGCTGATCGT GAC AAAGGACTTTGTTT ACTC

CCAAAGTTCCAATTGTCTTTTTGACAGAAACTACACACTTATGCTAAAAGATC

TTTTCTTGTCTCGCTTCAACTCCTTAATGGTCTTGCTCTCTCCCCCAGAGCCCC

GATACTCAGATGACTTGATATCTCAACTATGCCAGCTGTACATTGCTGGGGAT

CAAGTCTTGTCTATGTGTGGAAACTCCGGCTATGAAGTCATCAAAATATTGGA

GCC AT AT GTCGT GAAT AGTTT AGTCC AGAGAGC AGAAAAGTTT AGGCCTCTC

ATTCATTCCTTGGGAGACTTTCCTGTATTTATAAAAGACAAGGTAAGTCAACT

T GAAGAGACGTTCGGTCCCTGT GC AAGAAGGTTCTTT AGGGCTCTGGAT C AAT

TCGACAACATACATGACTTGGTTTTTGTGTTTGGCTGTTACAGGCATTGGGGG

C AC CC AT AT AT AG ATT AT C GA A AGGGTCTGT C A A A AC T AT AT GATC AGGTT C A

CCTTAAAAAAATGATAGATAAGTCCTACCAGGAGTGCTTAGCAAGCGACCTA

GCCAGGAGGATCCTTAGATGGGGTTTTGATAAGTACTCCAAGTGGTATCTGG

ATTCAAGATTCCTAGCCCGAGACCACCCCTTGACTCCTTATATCAAAACCCAA

ACATGGCCACCCAAACATATTGTAGACTTGGTGGGGGATACATGGCACAAGC

TCCCGATCACGCAGATCTTTGAGATTCCTGAATCAATGGATCCGTCAGAAATA

TTGGATGACAAATCACATTCTTTCACCAGAACGAGACTAGCTTCTTGGCTGTC

AGAAAACCGAGGGGGGCCTGTTCCTAGCGAAAAAGTTATTATCACGGCCCTG

TCTAAGCCGCCTGTCAATCCCCGAGAGTTTCTGAGGTCTATAGACCTCGGAGG

ATTGCCAGATGAAGACTTGATAATTGGCCTCAAGCCAAAGGAACGGGAATTG

AAGATTGAAGGTCGATTCTTTGCTCTAATGTCATGGAATCTAAGATTGTATTT

TGTCATCACTGAAAAACTCTTGGCCAACTACATCTTGCCACTTTTTGACGCGC

T GACT ATGAC AGAC AACCTGAAC AAGGTGTTT AAA AAGCTGATCGAC AGGGT

CACCGGGCAAGGGCTTTTGGACTATTCAAGGGTCACATATGCATTTCACCTGG

ACT AT GAAAAGT GGAAC AACC AT C AA AGATT AG AGT C AAC AGAGGATGT ATT

TTCTGTCCTAGATCAAGTGTTTGGATTGAAGAGAGTGTTTTCTAGAACACACG AGTTTTTTCAAAAGGCCTGGATCTATTATTCAGACAGATCAGACCTCATCGGG

TTACGGGAGGATCAAATATACTGCTTAGATGCGTCCAACGGCCCAACCTGTT

GGAATGGCCAGGATGGCGGGCTAGAAGGCTTACGGCAGAAGGGCTGGAGTC

T AGTC AGCTT ATTGATGAT AG AT AGAGAATCTC AAAT C AGGAAC AC AAGAAC

CAAAATACTAGCTCAAGGAGACAACCAGGTTTTATGTCCGACATACATGTTG

TCGCC AGGGCT ATCTC AAGAGGGGCTCCTCT AT GAATT GGAGAGAAT ATC AA

GGAATGCACTTTCGATATACAGAGCCGTCGAGGAAGGGGCATCTAAGCTAGG

GCTGAT CAT C AAGAAAGA AGAGACC AT GT GT AGTT AT GACTTCCTC ATCT ATG

GAAAAACCCCTTTGTTTAGAGGTAACATATTGGTGCCTGAGTCCAAAAGATG

GGCCAGAGTCTCTTGCGTCTCTAATGACCAAATAGTCAACCTCGCCAATATAA

TGTCGACAGTGTCCACCAATGCGCTAACAGTGGCACAACACTCTCAATCTTTG

ATCAAACCGATGAGGGATTTTCTGCTCATGTCAGTACAGGCAGTCTTTCACTA

CCTGCTATTTAGCCCAATCTTAAAGGGAAGAGTTTACAAGATTCTGAGCGCTG

AAGGGGAGAGCTTTCTCCTAGCCATGTCAAGGATAATCTATCTAGATCCTTCT

TTGGGAGGGATATCTGGAATGTCCCTCGGAAGATTCCATATACGACAGTTCTC

AGACCCTGTCTCTGAAGGGTTATCCTTCTGGAGAGAGATCTGGTTAAGCTCCC

AAGAGTCCTGGATTCACGCGTTGTGTCAAGAGGCTGGAAACCCAGATCTTGG

AGAGAGAACACTCGAGAGCTTCACTCGCCTTCTAGAAGATCCGACCACCTTA

A AT ATC AGAGGAGGGGC C AGTCC T AC C ATTCT AC T C A AGGAT GCA AT C AGA A

AGGCTTT AT AT GACGAGGT GGAC AAGGT GGAAAATTC AGAGTTTCGAGAGGC

AATCCTGTTGTCCAAGACCCATAGAGATAATTTTATACTCTTCTTAATATCTGT

TGAGCCTCTGTTTCCTCGATTTCTCAGTGAGCTATTCAGTTCGTCTTTTTTGGG

AATCCCCGAGTCAATCATTGGATTGATACAAAACTCCCGAACGATAAGAAGG

CAGTTTAGAAAGAGTCTCTCAAAAACTTTAGAAGAATCCTTCTACAACTCAG

AGATCCACGGGATTAGTCGGATGACCCAGACACCTCAGAGGGTTGGGGGGGT

GT GGCCTTGCTCTT C AGAGAGGGC AGATCT ACTT AGGGAGATCTCTT GGGGA

AGAAAAGTGGTAGGCACGACAGTTCCTCACCCTTCTGAGATGTTGGGATTAC

TTCCCAAGTCCTCTATTTCTTGCACTTGTGGAGCAACAGGAGGAGGCAATCCT

AGAGTTTCTGTATCAGTACTCCCGTCCTTTGATCAGTCATTTTTTTCACGAGGC

CCCCTAAAGGGATACTTGGGCTCGTCCACCTCTATGTCGACCCAGCTATTCCA

T GC AT GGG A A A A AGT C AC T A AT GTT CAT GT GGT G A AG AG AGC TC T AT C GT T A

AAAGAATCTATAAACTGGTTCATTACTAGAGATTCCAACTTGGCTCAAGCTCT

AATTAGGAACATTATGTCTCTGACAGGCCCTGATTTCCCTCTAGAGGAGGCCC

CTGTCTTCAAAAGGACGGGGTCAGCCTTGCATAGGTTCAAGTCTGCCAGATA CAGCGAAGGAGGGTATTCTTCTGTCTGCCCGAACCTCCTCTCTCATATTTCTG

TTAGTACAGACACCATGTCTGATTTGACCCAAGACGGGAAGAACTACGATTT

CATGTTCCAGCCATTGATGCTTTATGCACAGACATGGACATCAGAGCTGGTAC

AGAGAGACACAAGGCTAAGAGACTCTACGTTTCATTGGCACCTCCGATGCAA

CAGGTGTGTGAGACCCATTGACGACGTGACCCTGGAGACCTCTCAGATCTTC

GAGTTTCCGGATGTGTCGAAAAGAATATCCAGAATGGTTTCTGGGGCTGTGC

CTCACTTCCAGAGGCTTCCCGATATCCGTCTGAGACCAGGAGATTTTGAATCT

CTAAGCGGTAGAGAAAAGTCTCACCATATCGGATCAGCTCAGGGGCTCTTAT

ACTCAATCTTAGTGGCAATTCACGACTCAGGATACAATGATGGAACCATCTTC

CCTGTCAACATATACGGCAAGGTTTCCCCTAGAGACTATTTGAGAGGGCTCGC

AAGGGGAGTATTGATAGGATCCTCGATTTGCTTCTTGACAAGAATGACAAAT

ATCAATATTAATAGACCTCTTGAATTGGTCTCAGGGGTAATCTCATATATTCT

CCTGAGGCTAGATAACCATCCCTCCTTGTACATAATGCTCAGAGAACCGTCTC

TTAGAGGAGAGATATTTTCTATCCCTCAGAAAATCCCCGCCGCTTATCCAACC

ACTATGAAAGAAGGCAACAGATCAATCTTGTGTTATCTCCAACATGTGCTAC

GCTATGAGCGAGAGATAATCACGGCGTCTCCAGAGAATGACTGGCTATGGAT

CTTTTCAGACTTTAGAAGTGCCAAAATGACGTACCTATCCCTCATTACTTACC

AGTCTCATCTTCTACTCCAGAGGGTTGAGAGAAACCTATCTAAGAGTATGAG

AG AT AACCTGCGAC A ATT GAGTTCTTT GAT GAGGC AGGT GCTGGGCGGGC AC

GGAGAAGATACCTTAGAGTCAGACGACAACATTCAACGACTGCTAAAAGACT

CTTTACGAAGGACAAGATGGGTGGATCAAGAGGTGCGCCATGCAGCTAGAAC

CAT GACTGGAGATT AC AGCCCC A AC AAGAAGGT GTCCCGT AAGGT AGGATGT

TCAGAATGGGTCTGCTCTGCTCAACAGGTTGCAGTCTCTACCTCAGCAAACCC

GGCCCCTGTCTCGGAGCTTGACATAAGGGCCCTCTCTAAGAGGTTCCAGAAC

CCTTTGATCTCGGGCTTGAGAGTGGTTCAGTGGGCAACCGGTGCTCATTATAA

GCTTAAGCCTATTCTAGATGATCTCAATGTTTTCCCATCTCTCTGCCTTGTAGT

T GGGGACGGGT C AGGGGGGAT AT C AAGGGC AGTCCTC AAC ATGTTTCC AGAT

GCCAAGCTTGTGTTCAACAGTCTTTTAGAGGTGAATGACCTGATGGCTTCCGG

AACACATCCACTGCCTCCTTCAGCAATCATGAGGGGAGGAAATGATATCGTC

TCCAGAGTGATAGATCTTGACTCAATCTGGGAAAAACCGTCCGACTTGAGAA

ACTTGGCAACCTGGAAATACTTCCAGTCAGTCCAAAAGCAGGTCAACATGTC

CTATGACCTCATTATTTGCGATGCAGAAGTTACTGACATTGCATCTATCAACC

GGATCACCCTGTTAATGTCCGATTTTGCATTGTCTATAGATGGACCACTCTAT

TTGGTCTTCAAAACTTATGGGACTATGCTAGTAAATCCAAACTACAAGGCTAT TCAACACCTGTCAAGAGCGTTCCCCTCGGTCACAGGGTTTATCACCCAAGTAA

CTTCGTCTTTTTCATCTGAGCTCTACCTCCGATTCTCCAAACGAGGGAAGTTTT

TCAGAGATGCTGAGTACTTGACCTCTTCCACCCTTCGAGAAATGAGCCTTGTG

TTATTCAATTGTAGCAGCCCCAAGAGTGAGATGCAGAGAGCTCGTTCCTTGA

ACTATCAGGATCTTGTGAGAGGATTTCCTGAAGAAATCATATCAAATCCTTAC

AATGAGATGATCATAACTCTGATTGACAGTGATGTAGAATCTTTTCTAGTCCA

CAAGATGGTTGATGATCTTGAGTTACAGAGGGGAACTCTGTCTAAAGTGGCT

ATCATTATAGCCATCATGATAGTTTTCTCCAACAGAGTCTTCAACGTTTCCAA

ACCCCTAACTGACCCCTCGTTCTATCCACCGTCTGATCCCAAAATCCTGAGGC

ACTTCAACATATGTTGCAGTACTATGATGTATCTATCTACTGCTTTAGGTGAC

GTCCCTAGCTTCGCAAGACTTCACGACCTGTATAACAGACCTATAACTTATTA

CTTCAGAAAGCAAGTCATTCGAGGGAACGTTTATCTATCTTGGAGTTGGTCCA

ACGACACCTCAGTGTTCAAAAGGGTAGCCTGTAATTCTAGCCTGAGTCTGTCA

TCTCACTGGATCAGGTTGATTTACAAGATAGTGAAGACTACCAGACTCGTTGG

CAGCATCAAGGATCTATCCAGAGAAGTGGAAAGACACCTTCATAGGTACAAC

AGGTGGATCACCCTAGAGGATATCAGATCTAGATCATCCCTACTAGACTACA

GTTGCCTGTGAACCGGATACTCCTGGAAGCCTGCCCATGCTAAGACTCTTGTG

T GATGT ATCTT GAAAAAAAC AAGATCCT AAATCTGAACCTTTGGTTGTTTGAT

TGTTTTTCTCATTTTTGTTGTTTATTTGTTAAGCGT.

In one embodiment, the nucleic acid comprises the sequence of SEQ ID NO: 17, shown below (RABV vector: Coravax V6 South Africa):

ACGCTTAACAACCAGATCAAAGAAAAAACAGACATTGTCAATTGCAAAGCAA

AAATGTAACACCCCTACAATGGATGCCGACAAGATTGTATTCAAAGTCAATA

AT C AGGT GGT C TC TT T G A AGC C T GAG AT T AT C GT GG AT C A AT AT G AGT AC A AG

TACCCTGCCATCAAAGATTTGAAAAAGCCCTGTATAACCCTAGGAAAGGCTC

CCGATTTAAATAAAGCATACAAGTCAGTTTTGTCAGGCATGAGCGCCGCCAA

ACTTAATCCTGACGATGTATGTTCCTATTTGGCAGCGGCAATGCAGTTTTTTG

AGGGGACATGTCCGGAAGACTGGACCAGCTATGGAATTGTGATTGCACGAAA

AGGAGATAAGATCACCCCAGGTTCTCTGGTGGAGATAAAACGTACTGATGTA

GAAGGGAATT GGGCTCTGAC AGGAGGC AT GGAACTGAC AAGAGACCCC ACT

GTCCCTGAGCATGCGTCCTTAGTCGGTCTTCTCTTGAGTCTGTATAGGTTGAG

CAAAATATCCGGGCAAAACACTGGTAACTATAAGACAAACATTGCAGACAGG

ATAGAGCAGATTTTTGAGACAGCCCCTTTTGTTAAAATCGTGGAACACCATAC

TCTAATGACAACTCACAAAATGTGTGCTAATTGGAGTACTATACCAAACTTCA GATTTTTGGCCGGAACCTATGACATGTTTTTCTCCCGGATTGAGCATCTATATT

CAGCAATCAGAGTGGGCACAGTTGTCACTGCTTATGAAGACTGTTCAGGACT

GGTATCATTTACTGGGTTCATAAAACAAATCAATCTCACCGCTAGAGAGGCA

ATACTATATTTCTTCCACAAGAACTTTGAGGAAGAGATAAGAAGAATGTTTG

AGCCAGGGCAGGAGACAGCTGTTCCTCACTCTTATTTCATCCACTTCCGTTCA

CTAGGCTTGAGTGGGAAATCTCCTTATTCATCAAATGCTGTTGGTCACGTGTT

CAATCTCATTCACTTTGTAGGATGCTATATGGGTCAAGTCAGATCCCTAAATG

CAACGGTTATTGCTGCATGTGCTCCTCATGAAATGTCTGTTCTAGGGGGCTAT

CTGGGAGAGGAATTCTTCGGGAAAGGGAC ATTTGAAAGAAGATTCTTC AGAG

AT GAG A A AG A AC TT C A AG A AT AC G AGGC GGC T G A AC T G AC A A AG AC T G AC G

TAGCACTGGCAGATGATGGAACTGTCAACTCTGACGACGAGGACTACTTTTC

AGGT GAAACC AGAAGTCCGGAGGCTGTTT AT ACTCGAAT CAT GAT GAAT GGA

GGTCGACTAAAGAGATCTCACATACGGAGATATGTCTCAGTCAGTTCCAATC

ATCAAGCCCGTCCAAACTCATTCGCCGAGTTTCTAAACAAGACATATTCGAGT

GACTCATAAGAAGTTGAATAACAAAATGCCGGAAATCTACGGATTGTGTATA

TCCATCATGAAAAAAACTAACACCCCTCCTTTCGAACCATCCCAAACATGAG

CAAGATCTTTGTCAATCCTAGTGCTATTAGAGCCGGTCTGGCCGATCTTGAGA

T GGCTGAAGAAACTGTTGATCTGAT C AAT AGAAAT ATCGAAGAC AAT C AGGC

TCATCTCCAAGGGGAACCCATAGAGGTGGACAATCTCCCTGAGGATATGGGG

CGACTTCACCTGGATGATGGAAAATCGCCCAACCATGGTGAGATAGCCAAGG

T GGG AG A AGGC A AGT ATC G AG AGG AC T T T C AG AT GG AT G A AGG AG AGG AT C

CTAGCTTCCTGTTCCAGTCATACCTGGAAAATGTTGGAGTCCAAATAGTCAGA

CAAATGAGGTCAGGAGAGAGATTTCTCAAGATATGGTCACAGACCGTAGAAG

AGATTATATCCTATGTCGCGGTCAACTTTCCCAACCCTCCAGGAAAGTCTTCA

GAGGATAAATCAACCCAGACTACTGGCCGAGAGCTCAAGAAGGAGACAACA

CCCACTCCTTCTCAGAGAGAAAGCCAATCATCGAAAGCCAGGATGGCGGCTC

AAATTGCTTCTGGCCCTCCAGCCCTTGAATGGTCGGCTACCAATGAAGAGGAT

GATCTATCAGTGGAGGCTGAGATCGCTCACCAGATTGCAGAAAGTTTCTCCA

AAAAATATAAGTTTCCCTCTCGATCCTCAGGGATACTCTTGTATAATTTTGAG

C AATTGAAAAT GAACCTTGATGAT AT AGTT AAAGAGGC AAAAAAT GT ACC AG

GTGTGACCCGTTTAGCCCATGACGGGTCCAAACTCCCCCTAAGATGTGTACTG

GGATGGGTCGCTTTGGCCAACTCTAAGAAATTCCAGTTGTTAGTCGAATCCGA

CAAGCTGAGTAAAATCATGCAAGATGACTTGAATCGCTATACATCTTGCTAA

CCGAACCTCTCCCCTCAGTCCCTCTAGACAATAAAATCCGAGATGTCCCAAAG TCAACATGAAAAAAACAGGCAACACCACTGATAAAATGAACCTCCTACGTAA

GATAGTGAAAAACCGCAGGGACGAGGACACTCAAAAATCCTCTCCCGCGTCA

GCCCCTCTGGATGACGATGACTTGTGGCTTCCACCCCCTGAATACGTCCCGCT

GA A AGA ACTT AC AGGC A AG A AG A AC AT GAGGA AC TTTTGT AT C A AC GGA AG

GGTTAAAGTGTGTAGCCCGAATGGTTACTCGTTCAGGATCCTGCGGCACATTC

TGAAATCATTCGACGAGATATATTCTGGGAATCATAGGATGATCGGGTTAGTC

AAAGTGGTTATTGGACTGGCTTTGTCAGGATCTCCAGTCCCTGAGGGCCTGAA

CTGGGTATACAAATTGAGGAGAACCTTTATCTTCCAGTGGGCTGATTCCAGGG

GCCCTCTTGAAGGGGAGGAGTTGGAATACTCTCAGGAGATCACTTGGGATGA

T GAT AC T G AGTTCGTCGGATTGC A A AT A AGAGT GATT GC A A A AC AGT GT CAT

ATCC AGGGC AGAGTCTGGT GT AT C AAC AT GAACCCGAGAGC ATGT C AACT AT

GGTCTGACATGTCTCTTCAGACACAAAGGTCCGAAGAGGACAAAGATTCCTC

TCTGCTTCTAGAATAATCAGATTATATCCCGCAAATTTATCACTTGTTTACCTC

TGGAGGAGAGAACATATGGGCTCAACTCCAACCCTTGGGAGCAATATAACAA

AAAAC AT GTT ATGGT GCC ATT AAACCGCTGC ATTT CAT C AAAGTC AAGTT GAT

TACCTTTACATTTTGATCCTCTTGGATGTGAAAAAAACTATTAACATCCCTCA

AAAGACCccgggAAAGATGGTTCCTCAGGCTCTCCTGTTTGTACCCCTTCTGGTT

TTTCCATTGTGTTTTGGGAAATTCCCTATTTACACGATACCAGACAAGCTTGG

TCCCTGGAGTCCGATTGACATACATCACCTCAGCTGCCCAAACAATTTGGTAG

TGGAGGACGAAGGATGCACCAACCTGTCAGGGTTCTCCTACATGGAACTTAA

AGTTGGATACATCTTAGCCATAAAAGTGAACGGGTTCACTTGCACAGGCGTT

GTGACGGAGGCTGAAACCTACACTAACTTCGTTGGTTATGTCACAACCACGTT

CAAAAGAAAGCATTTCCGCCC AAC ACCAGATGC ATGT AGAGCCGCGTAC AAC

TGGAAGATGGCCGGTGACCCCAGATATGAAGAGTCTCTACACAATCCGTACC

CTGACTACCGCTGGCTTCGAACTGTAAAAACCACCAAGGAGTCTCTCGTTATC

ATATCTCCAAGTGTGGCAGATTTGGACCCATATGACAGATCCCTTCACTCGAG

GGTCTTCCCTAGCGGGAAGTGCTCAGGAGTAGCGGTGTCTTCTACCTACTGCT

CCACTAACCACGATTACACCATTTGGATGCCCGAGAATCCGAGACTAGGGAT

GTCTTGTGACATTTTTACCAATAGTAGAGGGAAGAGAGCATCCAAAGGGAGT

GAGACTTGCGGCTTTGT AG AT GAAAGAGGCCT AT AT AAGTCTTT AAAAGGAG

CAT GC A A ACTC A AGTT AT GT GGAGTTC T AGGAC TT AG AC TT AT GGAT GGA AC

ATGGGTCTCGATGCAAACATCAAATGAAACCAAATGGTGCCCTCCCGATAAG

TTGGTGAACCTGCACGACTTTCGCTCAGACGAAATTGAGCACCTTGTTGTAGA

GGAGTTGGTCAGGAAGAGAGAGGAGTGTCTGGATGCACTAGAGTCCATCATG AC A AC C A AGT C AGT GAGTTT C AGAC GTCTC AGT C ATTT A AGA A A AC TT GT C CC

T GGGTTTGGAAAAGC AT AT ACC AT ATTC AAC AAGACCTTGAT GGAAGCCGAT

GCTCACTACAAGTCAGTCgagACTTGGAATGAGATCCTCCCTTCAAAAGGGTG

TTTAAGAGTTGGGGGGAGGTGTCATCCTCATGTGAACGGGGTGTTTTTCAATG

GTATAATATTAGGACCTGACGGCAATGTCTTAATCCCAGAGATGCAATCATCC

CTCCTCCAGCAACATATGGAGTTGTTGGAATCCTCGGTTATCCCCCTTGTGCA

CCCCCTGGCAGACCCGTCTACCGTTTTCAAGGACGGTGACGAGGCTGAGGAT

TTTGTTGAAGTTCACCTTCCCGATGTGCACAATCAGGTCTCAGGAGTTGACTT

GGGTCTCCCGAACTGGGGGAAGT AT GT ATT ACTGAGTGC AGGGGCCCTGACT

GCCTT GATGTT GAT AATTTTCCTGAT GAC AT GTTGT AGAAGAGT C AATCGAT C

AGAACCTACGCAACACAATCTCAGAGGGACAGGGAGGGAGGTGTCAGTCAC

T C CC C A A AGC GGGA AGAT CAT ATCTTC AT GGGA AT C AC AC A AG AGT GGGGGT

GAG AC C AGAC T GT A AttaattaaC GT C CTTT C A AC GAT C C A AGTCcatgaaaaaaactaacac ccctcccgtacgaccATGTTCGTGTTTCTGGTGCTGCTGCCTCTGGTGAGCTCCCAGTG

CGTGAACTTCACCACAAGGACCCAGCTGCCCCCTGCCTATACCAATTCCTTCA

CACGGGGCGTGTACTATCCCGACAAGGTGTTCCGGAGCAGCGTGCTGCACTC

CACACAGGATCTGTTTCTGCCTTTCTTTTCTAACGTGACCTGGTTCCACGCCAT

CCACGTGAGCGGCACCAATGGCACAAAGCGGTTCGCCAATCCAGTGCTGCCC

TTTAACGATGGCGTGTACTTCGCCTCCACCGAGAAGTCTAACATCATCAGAGG

CTGGATCTTTGGCACCACACTGGACAGCAAGACACAGTCCCTGCTGATCGTG

AACAATGCCACCAACGTGGTCATCAAGGTGTGCGAGTTCCAGTTTTGTAATG

ATCCATTCCTGGGCGTGTACTATCACAAGAACAATAAGTCTTGGATGGAGAG

CGAGTTTCGCGTGTATTCCTCTGCCAACAATTGCACATTTGAGTACGTGTCCC

AGCCCTTCCTGATGGACCTGGAGGGCAAGCAGGGCAATTTCAAGAACCTGAG

GGAGTTCGTGTTTAAGAATATCGATGGCTACTTCAAAATCTACTCCAAGCACA

CCCCAATCAACCTGGTGCGCGGCCTGCCACAGGGCTTCTCTGCCCTGGAGCCA

CTGGTGGATCTGCCCATCGGCATCAACATCACCCGGTTTCAGACACTGCTGGC

CCTGCACAGAAGCTACCTGACACCAGGCGACAGCTCCTCTGGATGGACCGCA

GGAGCAGCAGCCTACTATGTGGGCTATCTGCAGCCCAGGACCTTCCTGCTGA

AGTACAACGAGAATGGCACCATCACAGACGCCGTGGATTGCGCCCTGGATCC

CCTGTCTGAGACCAAGTGTACACTGAAGAGCTTTACCGTGGAGAAGGGCATC

TATCAGACAAGCAATTTCAGGGTGCAGCCTACCGAGTCCATCGTGCGCTTTCC

CAATATCACAAACCTGTGCCCTTTTGGCGAGGTGTTCAACGCAACCCGCTTCG

CCAGCGTGTACGCCTGGAATAGGAAGCGCATCTCCAACTGCGTGGCCGACTA TTCTGTGCTGTACAACAGCGCCTCCTTCTCTACCTTTAAGTGCTATGGCGTGA

GCCCCACAAAGCTGAATGACCTGTGCTTTACCAACGTGTACGCCGATTCCTTC

GTGATCAGGGGCGACGAGGTGCGCCAGATCGCACCAGGACAGACAGGCAAT

ATCGCAGACTACAATTATAAGCTGCCTGACGATTTCACCGGCTGCGTGATCGC

CTGGAACTCTAACAATCTGGATAGCAAAGTGGGCGGCAACTACAATTATCTG

TACCGGCTGTTTAGAAAGTCTAATCTGAAGCCATTCGAGAGGGACATCTCCA

CAGAAATCTACCAGGCCGGCTCTACCCCCTGCAATGGCGTGAAGGGCTTTAA

CTGTTATTTCCCTCTGCAGAGCTACGGCTTCCAGCCAACATATGGCGTGGGCT

ATCAGCCCTACCGCGTGGTGGTGCTGTCTTTTGAGCTGCTGCACGCACCTGCA

AC AGT GT GCGGAC C A A AGA AGAGC AC C A ATCTGGT GA AGA AC A AGT GC GT G

AACTTCAACTTCAACGGACTGACCGGAACAGGCGTGCTGACCGAGTCCAACA

AGAAGTTCCTGCCTTTTCAGCAGTTCGGCAGGGACATCGCAGATACCACAGA

CGCCGTGCGCGACCCTCAGACCCTGGAGATCCTGGACATCACACCATGCTCCT

TCGGCGGCGTGTCTGTGATCACACCAGGCACCAATACAAGCAACCAGGTGGC

CGTGCTGTATCAGGGCGTGAATTGTACCGAGGTGCCAGTGGCAATCCACGCA

GATCAGCTGACCCCTACATGGCGGGTGTACTCTACCGGCAGCAACGTGTTCC

AGACAAGAGCCGGATGCCTGATCGGAGCAGAGCACGTGAACAATAGCTATG

AGTGCGACATCCCTATCGGCGCCGGCATCTGTGCCTCCTACCAGACCCAGAC

AAACTCCCCAGAATCAAGCGTGATTCCTCTGGTCCATCCACTGGCAGATCCCT

CCACAGTGTTCAAAGACGGAGATGAGGCCGAAGACTTTGTGGAAGTCCACCT

GCCTGATGTGCATAACCAGGTGTCTGGCGTCGACCTGGGACTGCCAAATTGG

GGCAAGTACGTGCTGCTGAGTGCTGGAGCACTGACTGCCCTGATGCTGATCA

TTTTCCTGATGACCTGCTGTCGGCGCGTGAACAGAAGTGAGCCCACTCAGCAC

AATCTGCGAGGAACCGGGAGAGAAGT GT C AGT C AC ACCTC AGAGC GGGAAA

ATCATTAGTAGTTGGGAATCACATAAAAGCGGGGGCGAGACCAGGCTGggatcc ggctccggcgagggcaggggaagtctactaacatgcggggacgtggaggaaaatcccggcccc AT GC T C GAT C C

TGGAGAGGTCTATGATGACCCTATTGACCCAATCGAGTTAGAGGCTGAACCC

AGAGGAACCCCCATTGTCCCCAACATCTTGAGGAACTCTGACTACAATCTCA

ACTCTCCTTTGATAGAAGATCCTGCTAGACTAATGTTAGAATGGTTAAAAACA

GGGAATAGACCTTATCGGATGACTCTAACAGACAATTGCTCCAGGTCTTTCAG

AGTTTTGAAAGATTATTTCAAGAAGGTAGATTTGGGTTCTCTCAAGGTGGGCG

GAATGGCTGCACAGTCAATGATTTCTCTCTGGTTATATGGTGCCCACTCTGAA

TCCAACAGGAGCCGGAGATGTATAACAGACTTGGCCCATTTCTATTCCAAGTC

GTCCCCCATAGAGAAGCTGTTGAATCTCACGCTAGGAAATAGAGGGCTGAGA ATCCCCCCAGAGGGAGTGTTAAGTTGCCTTGAGAGGGTTGATTATGATAATG

CATTTGGAAGGTATCTTGCCAACACGTATTCCTCTTACTTGTTCTTCCATGTAA

TCACCTTATACATGAACGCCCTAGACTGGGATGAAGAAAAGACCATCCTAGC

ATTATGGAAAGATTTAACCTCAGTGGACATCGGGAAGGACTTGGTAAAGTTC

AAAGACCAAATATGGGGACTGCTGATCGTGACAAAGGACTTTGTTTACTCCC

AAAGTTCCAATTGTCTTTTTGACAGAAACTACACACTTATGCTAAAAGATCTT

TTCTTGTCTCGCTTCAACTCCTTAATGGTCTTGCTCTCTCCCCCAGAGCCCCGA

TACTCAGATGACTTGATATCTCAACTATGCCAGCTGTACATTGCTGGGGATCA

AGTCTTGTCTATGTGTGGAAACTCCGGCTATGAAGTCATCAAAATATTGGAGC

CATATGTCGTGAATAGTTTAGTCCAGAGAGCAGAAAAGTTTAGGCCTCTCATT

CATTCCTTGGGAGACTTTCCTGTATTTATAAAAGACAAGGTAAGTCAACTTGA

AGAGACGTTCGGTCCCTGTGCAAGAAGGTTCTTTAGGGCTCTGGATCAATTCG

ACAACATACATGACTTGGTTTTTGTGTTTGGCTGTTACAGGCATTGGGGGCAC

CC AT AT AT AG ATT AT C GA A AGGGTCTGT C A A A AC T AT AT GAT C AGGTT C AC CT

TAAAAAAATGATAGATAAGTCCTACCAGGAGTGCTTAGCAAGCGACCTAGCC

AGGAGGATCCTTAGATGGGGTTTTGATAAGTACTCCAAGTGGTATCTGGATTC

AAGATTCCTAGCCCGAGACCACCCCTTGACTCCTTATATCAAAACCCAAACAT

GGC C ACC C A A AC AT ATT GT AG AC TT GGT GGGGGAT AC AT GGC AC A AGC TC CC

GATCACGCAGATCTTTGAGATTCCTGAATCAATGGATCCGTCAGAAATATTGG

ATGACAAATCACATTCTTTCACCAGAACGAGACTAGCTTCTTGGCTGTCAGAA

AACCGAGGGGGGCCTGTTCCTAGCGAAAAAGTTATTATCACGGCCCTGTCTA

AGCCGCCTGTCAATCCCCGAGAGTTTCTGAGGTCTATAGACCTCGGAGGATTG

CC AGATGAAGACTT GAT AATT GGCCTC AAGCC AAAGGAACGGGAATTGAAGA

TTGAAGGTCGATTCTTTGCTCTAATGTCATGGAATCTAAGATTGTATTTTGTCA

TCACTGAAAAACTCTTGGCCAACTACATCTTGCCACTTTTTGACGCGCTGACT

AT GAC AGAC AACCTGAAC AAGGT GTTT AAAAAGCTGATCGAC AGGGT C ACCG

GGCAAGGGCTTTTGGACTATTCAAGGGTCACATATGCATTTCACCTGGACTAT

GAAAAGTGGAACAACCATCAAAGATTAGAGTCAACAGAGGATGTATTTTCTG

TCCTAGATCAAGTGTTTGGATTGAAGAGAGTGTTTTCTAGAACACACGAGTTT

TTT C AAAAGGCCTGGATCT ATT ATT C AGAC AG AT C AGACCTC ATCGGGTT ACG

GGAGGATCAAATATACTGCTTAGATGCGTCCAACGGCCCAACCTGTTGGAAT

GGCCAGGATGGCGGGCTAGAAGGCTTACGGCAGAAGGGCTGGAGTCTAGTC

AGCTTATTGATGATAGATAGAGAATCTCAAATCAGGAACACAAGAACCAAAA

TACTAGCTCAAGGAGACAACCAGGTTTTATGTCCGACATACATGTTGTCGCCA GGGC T AT C T C A AG AGGGGC TCCTCTAT G A ATT GG AG AG A AT AT C A AGG A AT G

CACTTTCGATATACAGAGCCGTCGAGGAAGGGGCATCTAAGCTAGGGCTGAT

CAT C A AG A A AG A AG AG AC CAT GT GT AGTT AT GAC TTCCTC ATCT AT GGA A A A

ACCCCTTTGTTTAGAGGTAACATATTGGTGCCTGAGTCCAAAAGATGGGCCA

GAGTCTCTTGCGTCTCTAATGACCAAATAGTCAACCTCGCCAATATAATGTCG

ACAGTGTCCACCAATGCGCTAACAGTGGCACAACACTCTCAATCTTTGATCAA

ACCGATGAGGGATTTTCTGCTCATGTCAGTACAGGCAGTCTTTCACTACCTGC

TATTTAGCCCAATCTTAAAGGGAAGAGTTTACAAGATTCTGAGCGCTGAAGG

GGAGAGCTTTCTCCTAGCCATGTCAAGGATAATCTATCTAGATCCTTCTTTGG

GAGGGAT ATCTGGAATGTCCCTCGGAAGATTCC AT AT ACGAC AGTTCTC AGA

CCCTGTCTCTGAAGGGTTATCCTTCTGGAGAGAGATCTGGTTAAGCTCCCAAG

AGTCCTGGATTCACGCGTTGTGTCAAGAGGCTGGAAACCCAGATCTTGGAGA

GAGAACACTCGAGAGCTTCACTCGCCTTCTAGAAGATCCGACCACCTTAAAT

AT C AG AGG AGGGGC C AGTCC T AC C ATTCT ACTC A AGGAT GCA AT C AGA A AGG

CTTT AT ATGACGAGGT GGAC AAGGT GGAAAATTC AGAGTTTCGAGAGGC AAT

CCTGTTGTCCAAGACCCATAGAGATAATTTTATACTCTTCTTAATATCTGTTGA

GCCTCTGTTTCCTCGATTTCTCAGTGAGCTATTCAGTTCGTCTTTTTTGGGAAT

CCCCGAGTCAATCATTGGATTGATACAAAACTCCCGAACGATAAGAAGGCAG

TTT AGAAAGAGTCTCTC AAAAACTTT AGAAGAATCCTTCT AC AACTC AGAGAT

CC ACGGGATT AGTCGGATGACCC AGAC ACCTC AGAGGGTT GGGGGGGT GT GG

CCTTGCTCTTCAGAGAGGGCAGATCTACTTAGGGAGATCTCTTGGGGAAGAA

AAGTGGTAGGCACGACAGTTCCTCACCCTTCTGAGATGTTGGGATTACTTCCC

AAGTCCTCTATTTCTTGCACTTGTGGAGCAACAGGAGGAGGCAATCCTAGAG

TTTCTGTATCAGTACTCCCGTCCTTTGATCAGTCATTTTTTTCACGAGGCCCCC

TAAAGGGATACTTGGGCTCGTCCACCTCTATGTCGACCCAGCTATTCCATGCA

T GGG A A A A AGT C AC T AAT GT TC AT GT GGT G A AG AG AGC TC T AT C GT T A A A AG

AATCTATAAACTGGTTCATTACTAGAGATTCCAACTTGGCTCAAGCTCTAATT

AGGAACATTATGTCTCTGACAGGCCCTGATTTCCCTCTAGAGGAGGCCCCTGT

CTTCAAAAGGACGGGGTCAGCCTTGCATAGGTTCAAGTCTGCCAGATACAGC

GAAGGAGGGTATTCTTCTGTCTGCCCGAACCTCCTCTCTCATATTTCTGTTAGT

ACAGACACCATGTCTGATTTGACCCAAGACGGGAAGAACTACGATTTCATGT

TCC AGCC ATTGAT GCTTT AT GC AC AGAC AT GGAC ATC AGAGCTGGT AC AG AG

AGACACAAGGCTAAGAGACTCTACGTTTCATTGGCACCTCCGATGCAACAGG

TGTGTGAGACCCATTGACGACGTGACCCTGGAGACCTCTCAGATCTTCGAGTT TCCGGATGTGTCGAAAAGAATATCCAGAATGGTTTCTGGGGCTGTGCCTCACT

TCCAGAGGCTTCCCGATATCCGTCTGAGACCAGGAGATTTTGAATCTCTAAGC

GGTAGAGAAAAGTCTCACCATATCGGATCAGCTCAGGGGCTCTTATACTCAA

TCTTAGTGGCAATTCACGACTCAGGATACAATGATGGAACCATCTTCCCTGTC

AACATATACGGCAAGGTTTCCCCTAGAGACTATTTGAGAGGGCTCGCAAGGG

GAGT ATT GAT AGGATCCTCGATTT GCTTCTT GAC AAGAATGAC AAAT ATC AAT

ATTAATAGACCTCTTGAATTGGTCTCAGGGGTAATCTCATATATTCTCCTGAG

GCTAGATAACCATCCCTCCTTGTACATAATGCTCAGAGAACCGTCTCTTAGAG

GAGAGATATTTTCTATCCCTCAGAAAATCCCCGCCGCTTATCCAACCACTATG

AAAGAAGGCAACAGATCAATCTTGTGTTATCTCCAACATGTGCTACGCTATG

AGCGAGAGATAATCACGGCGTCTCCAGAGAATGACTGGCTATGGATCTTTTC

AGACTTTAGAAGTGCCAAAATGACGTACCTATCCCTCATTACTTACCAGTCTC

ATCTTCTACTCCAGAGGGTTGAGAGAAACCTATCTAAGAGTATGAGAGATAA

CCTGCGACAATTGAGTTCTTTGATGAGGCAGGTGCTGGGCGGGCACGGAGAA

GATACCTTAGAGTCAGACGACAACATTCAACGACTGCTAAAAGACTCTTTAC

GAAGGAC AAGAT GGGTGGATC AAGAGGT GCGCC AT GC AGCT AGAACC AT GA

CTGGAGATTACAGCCCCAACAAGAAGGTGTCCCGTAAGGTAGGATGTTCAGA

ATGGGTCTGCTCTGCTCAACAGGTTGCAGTCTCTACCTCAGCAAACCCGGCCC

CTGTCTCGGAGCTTGACATAAGGGCCCTCTCTAAGAGGTTCCAGAACCCTTTG

ATCTCGGGCTTGAGAGTGGTTC AGT GGGC AACCGGT GCTC ATT AT AAGCTT AA

GCCTATTCTAGATGATCTCAATGTTTTCCCATCTCTCTGCCTTGTAGTTGGGGA

CGGGTCAGGGGGGATATCAAGGGCAGTCCTCAACATGTTTCCAGATGCCAAG

CTTGTGTTCAACAGTCTTTTAGAGGTGAATGACCTGATGGCTTCCGGAACACA

TCCACTGCCTCCTTCAGCAATCATGAGGGGAGGAAATGATATCGTCTCCAGA

GTGATAGATCTTGACTCAATCTGGGAAAAACCGTCCGACTTGAGAAACTTGG

CAACCTGGAAATACTTCCAGTCAGTCCAAAAGCAGGTCAACATGTCCTATGA

CCTCATTATTTGCGATGCAGAAGTTACTGACATTGCATCTATCAACCGGATCA

CCCTGTTAATGTCCGATTTTGCATTGTCTATAGATGGACCACTCTATTTGGTCT

T C A A A AC TT AT GGGAC T AT GCT AGT A A ATCC A A ACT AC A AGGC T ATTC A AC A

CCTGTCAAGAGCGTTCCCCTCGGTCACAGGGTTTATCACCCAAGTAACTTCGT

CTTTTTCATCTGAGCTCTACCTCCGATTCTCCAAACGAGGGAAGTTTTTCAGA

GATGCTGAGTACTTGACCTCTTCCACCCTTCGAGAAATGAGCCTTGTGTTATT

CAATTGTAGCAGCCCCAAGAGTGAGATGCAGAGAGCTCGTTCCTTGAACTAT

C AGGATCTT GTGAGAGGATTTCCTGAAGAAAT CAT AT C AAATCCTT AC AAT G AGATGATCATAACTCTGATTGACAGTGATGTAGAATCTTTTCTAGTCCACAAG

AT GGTT GAT GAT C TT GAGTT AC AGAGGGGA AC TC T GTCT A A AGT GGCT AT CAT

TATAGCCATCATGATAGTTTTCTCCAACAGAGTCTTCAACGTTTCCAAACCCC

TAACTGACCCCTCGTTCTATCCACCGTCTGATCCCAAAATCCTGAGGCACTTC

AACATATGTTGCAGTACTATGATGTATCTATCTACTGCTTTAGGTGACGTCCC

TAGCTTCGCAAGACTTCACGACCTGTATAACAGACCTATAACTTATTACTTCA

GAAAGCAAGTCATTCGAGGGAACGTTTATCTATCTTGGAGTTGGTCCAACGA

CACCTCAGTGTTCAAAAGGGTAGCCTGTAATTCTAGCCTGAGTCTGTCATCTC

ACTGGAT C AGGTTGATTT AC AAGAT AGT GAAGACT ACC AGACTCGTT GGC AG

CATCAAGGATCTATCCAGAGAAGTGGAAAGACACCTTCATAGGTACAACAGG

TGGATCACCCTAGAGGATATCAGATCTAGATCATCCCTACTAGACTACAGTTG

CCTGTGAACCGGATACTCCTGGAAGCCTGCCCATGCTAAGACTCTTGTGTGAT

GTATCTTGAAAAAAACAAGATCCTAAATCTGAACCTTTGGTTGTTTGATTGTT

TTTCTCATTTTTGTTGTTTATTTGTTAAGCGT.

In one embodiment, the nucleic acid comprises the sequence of SEQ ID NO: 18, shown below (VSV vector: Convac VI China):

ACGAAGAC AAAC AAACC ATT ATT AT C ATT AAAAGGCTC AGGAGAAACTTT AA

C AGT AAT C AAA ATGTCTGTT AC AGTC AAGAGAAT C ATTGAC AAC AC AGTC AT

AGTTCCAAAACTTCCTGCAAATGAGGATCCAGTGGAATACCCGGCAGATTAC

TTCAGAAAATCAAAGGAGATTCCTCTTTACATCAATACTACAAAAAGTTTGTC

AGATCTAAGAGGATATGTCTACCAAGGCCTCAAATCCGGAAATGTATCAATC

AT AC AT GT C A AC AGC T AC TT GT AT GG AGC ATT A A AGG AC ATC C GGGGT A AGT

T GG AT A A AG AT T GGT C A AGTT T C GG A AT AAAC ATC GGG A A AGC AGGGG AT AC

AATCGGAATATTTGACCTTGTATCCTTGAAAGCCCTGGACGGCGTACTTCCAG

AT GGAGT ATCGGAT GCTTCC AGAACC AGCGC AGAT GAC AAAT GGTT GCCTTT

GT AT C T AC TT GGCTT AT AC AG AGT GGGC AG A AC AC A A AT GCC T GA AT AC AGA

A A A A AGC TC AT GGAT GGGC T GAC A A AT C A AT GCA A A AT GAT C A AT GA AC AGT

TTGAACCTCTTGTGCCAGAAGGTCGTGACATTTTTGATGTGTGGGGAAATGAC

AGTAATTACACAAAAATTGTCGCTGCAGTGGACATGTTCTTCCACATGTTCAA

AAAACATGAATGTGCCTCGTTCAGATACGGAACTATTGTTTCCAGATTCAAAG

ATTGTGCTGCATTGGCAACATTTGGACACCTCTGCAAAATAACCGGAATGTCT

ACAGAAGATGTAACGACCTGGATCTTGAACCGAGAAGTTGCAGATGAAATGG

TCCAAATGATGCTTCCAGGCCAAGAAATTGACAAGGCCGATTCATACATGCC

TTATTTGATCGACTTTGGATTGTCTTCTAAGTCTCCATATTCTTCCGTCAAAAA CCCTGCCTTCCACTTCTGGGGGCAATTGACAGCTCTTCTGCTCAGATCCACCA

GAGCAAGGAATGCCCGACAGCCTGATGACATTGAGTATACATCTCTTACTAC

AGCAGGTTTGTTGTACGCTTATGCAGTAGGATCCTCTGCCGACTTGGCACAAC

AGTTTTGTGTTGGAGATAACAAATACACTCCAGATGATAGTACCGGAGGATT

GACGACTAATGCACCGCCACAAGGCAGAGATGTGGTCGAATGGCTCGGATGG

T TT G A AG AT C A A A AC AG A A A AC C G AC TC C T GAT AT GAT GC AGT AT GC G A A A A

GAGCAGTCATGTCACTGCAAGGCCTAAGAGAGAAGACAATTGGCAAGTATGC

TAAGTCAGAATTTGACAAATGACCCTATAATTCTCAGATCACCTATTATATAT

TATGCTACATATGAAAAAAACTAACAGATATCATGGATAATCTCACAAAAGT

TCGTGAGTATCTCAAGTCCTATTCTCGTCTGGATCAGGCGGTAGGAGAGATAG

ATGAGATCGAAGCACAACGAGCTGAAAAGTCCAATTATGAGTTGTTCCAAGA

GGATGGAGTGGAAGAGCATACTAAGCCCTCTTATTTTCAGGCAGCAGATGAT

TCTGAC AC AGA AT C T GA AC C AG A A ATT GA AG AC A AT C A AGGTTT GT AT GC AC

CAGATCCAGAAGCTGAGCAAGTTGAAGGCTTTATACAGGGGCCTTTAGATGA

CT AT GC AGAT GAGGAAGT GGAT GTT GT ATTT ACTTCGGACTGGAAAC AGCCT

GAGCTTGAATCTGACGAGCATGGAAAGACCTTACGGTTGACATCGCCAGAGG

GTTTAAGTGGAGAGCAGAAATCCCAGTGGCTTTCGACGATTAAAGCAGTCGT

GC AAAGTGCC AAAT ACTGGAATCTGGC AGAGT GC AC ATTTGAAGC ATCGGGA

G A AGGGGT C AT T AT G A AGG AGC GC C AG AT A AC T C C GGAT GT AT AT A AGGT C A

CTCCAGTGATGAACACACATCCGTCCCAATCAGAAGCAGTATCAGATGTTTG

GTCTCTCTCAAAGACATCCATGACTTTCCAACCCAAGAAAGCAAGTCTTCAGC

CTCTCACCATATCCTTGGATGAATTGTTCTCATCTAGAGGAGAGTTCATCTCT

GTCGGAGGTGACGGACGAATGTCTCATAAAGAGGCCATCCTGCTCGGCCTGA

GATACAAAAAGTTGTACAATCAGGCGAGAGTCAAATATTCTCTGTAGACTAT

GAAAAAAAGTAACAGATATCACGATCTAAGTGTTATCCCAATCCATTCATCA

T G AGTT C C TT A A AG A AG AT TC TC GGT C T G A AGGGG A A AGGT A AG A A AT C T A A

GAAATTAGGGATCGCACCACCCCCTTATGAAGAGGACACTAGCATGGAGTAT

GCTCCGAGCGCTCCAATTGACAAATCCTATTTTGGAGTTGACGAGATGGACA

CCTATGATCCGAATCAATTAAGATATGAGAAATTCTTCTTTACAGTGAAAATG

ACGGTTAGATCTAATCGTCCGTTCAGAACATACTCAGATGTGGCAGCCGCTGT

ATCCCATTGGGATCACATGTACATCGGAATGGCAGGGAAACGTCCCTTCTAC

AAAATCTTGGCTTTTTTGGGTTCTTCTAATCTAAAGGCCACTCCAGCGGTATT

GGCAGATCAAGGTCAACCAGAGTATCACACTCACTGCGAAGGCAGGGCTTAT

TTGCCACATAGGATGGGGAAGACCCCTCCCATGCTCAATGTACCAGAGCACT T C AGAAGACC ATTC AAT AT AGGTCTTT AC AAGGGAACGATTGAGCTC AC A AT

GACCATCTACGATGATGAGTCACTGGAAGCAGCTCCTATGATCTGGGATCATT

TCAATTCTTCCAAATTTTCTGATTTCAGAGAGAAGGCCTTAATGTTTGGCCTG

ATTGTCGAGAAAAAGGCATCTGGAGCGTGGGTCCTGGATTCTATCAGCCACT

TCAAATGAGCTAGTCTAACTTCTAGCTTCTGAACAATCCCCGGTTTACTCAGT

CTCTCCTAATTCCAGCCTCTCGAACAACTAATATCCTGTCTTTTCTATCCCTAT

GAAAAAAACTAACAGAGATCGATCTGTTTACGCGTCACTATGAAGTGCCTTTT

GTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCC

ACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGC

CCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCATAC

A AGT C A A A AT GCC C A AGAGTC AC A AGGC T ATT C A AGC AGACGGTT GGAT GT G

TCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGT

ATATAACACAGTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGA

AAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCT

C AAAGTT GTGGAT AT GC AACTGT GACGGAT GCCGAAGC AGT GATTGTCC AGG

TGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCA

CAGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTC

TACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCA

TTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGA

AAGGAGGGC AC AGGGTT C AGAAGT AACT ACTTTGCTT AT GAAACTGGAGGC A

AGGCCTGC AAAAT GC AAT ACTGC AAGC ATT GGGGAGTC AGACTCCC ATC AGG

TGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTG

AATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTA

AGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAAC

CTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATC

TTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACC

CTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCT

C T C A AG A AT GGT C GG A AT GAT C AGT GG A AC T AC C AC AG A A AGGG A AC TGT GG

GAT GACTGGGC ACC AT AT GAAGACGT GGAAATTGGACCC AAT GGAGTTCTGA

GGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTG

GACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACAT

TCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATA

CTGGGCT ATCC AAAAATCC AATCGAGCTTGT AGAAGGTT GGTTC AGT AGTT G

GAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATT CTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGA

AAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACTCAA

ATCCTGCTAGGTATGAAAAAAACTAACaGATATCACGCTCGAGCGTACGCCA

CCATGTTCGTGTTTCTGGTGCTGCTGCCTCTGGTGAGCTCCCAGTGCGTGAAC

CTGACCACAAGGACCCAGCTGCCCCCTGCCTATACCAATTCCTTCACACGGGG

CGTGTACTATCCCGACAAGGTGTTCCGGAGCAGCGTGCTGCACTCCACACAG

GATCTGTTTCTGCCTTTCTTTTCTAACGTGACCTGGTTCCACGCCATCCACGTG

AGCGGCACCAATGGCACAAAGCGGTTCGACAATCCAGTGCTGCCCTTTAACG

ATGGCGTGTACTTCGCCTCCACCGAGAAGTCTAACATCATCAGAGGCTGGAT

CTTTGGCACCACACTGGACAGCAAGACACAGTCCCTGCTGATCGTGAACAAT

GCCACCAACGTGGTCATCAAGGTGTGCGAGTTCCAGTTTTGTAATGATCCATT

CC T GGGC GT GT AC T AT C AC A AG A AC A AT A AGT C TT GGAT GGAGAGC GAGTTT

CGCGTGTATTCCTCTGCCAACAATTGCACATTTGAGTACGTGTCCCAGCCCTT

CCTGAT GGACCTGGAGGGC AAGC AGGGC AATTT C AAGA ACCTGAGGGAGTT C

GTGTTTAAGAATATCGATGGCTACTTCAAAATCTACTCCAAGCACACCCCAAT

CAACCTGGTGCGCGACCTGCCACAGGGCTTCTCTGCCCTGGAGCCACTGGTG

GATCTGCCCATCGGCATCAACATCACCCGGTTTCAGACACTGCTGGCCCTGCA

CAGAAGCTACCTGACACCAGGCGACAGCTCCTCTGGATGGACCGCAGGAGCA

GCAGCCTACTATGTGGGCTATCTGCAGCCCAGGACCTTCCTGCTGAAGTACAA

CGAGAATGGCACCATCACAGACGCCGTGGATTGCGCCCTGGATCCCCTGTCT

GAGACCAAGTGTACACTGAAGAGCTTTACCGTGGAGAAGGGCATCTATCAGA

CAAGCAATTTCAGGGTGCAGCCTACCGAGTCCATCGTGCGCTTTCCCAATATC

ACAAACCTGTGCCCTTTTGGCGAGGTGTTCAACGCAACCCGCTTCGCCAGCGT

GTACGCCTGGAATAGGAAGCGCATCTCCAACTGCGTGGCCGACTATTCTGTG

CTGTACAACAGCGCCTCCTTCTCTACCTTTAAGTGCTATGGCGTGAGCCCCAC

AAAGCTGAATGACCTGTGCTTTACCAACGTGTACGCCGATTCCTTCGTGATCA

GGGGCGACGAGGTGCGCCAGATCGCACCAGGACAGACAGGCAAGATCGCAG

ACTACAATTATAAGCTGCCTGACGATTTCACCGGCTGCGTGATCGCCTGGAAC

TC T A AC A AT C T GGAT AGC A A AGT GGGC GGC A AC T AC A AT T AT C T GT AC C GGC

TGTTTAGAAAGTCTAATCTGAAGCCATTCGAGAGGGACATCTCCACAGAAAT

CTACCAGGCCGGCTCTACCCCCTGCAATGGCGTGGAGGGCTTTAACTGTTATT

TCCCTCTGCAGAGCTACGGCTTCCAGCCAACAAACGGCGTGGGCTATCAGCC

CTACCGCGTGGTGGTGCTGTCTTTTGAGCTGCTGCACGCACCTGCAACAGTGT

GCGGACC A AAGAAGAGC ACC AATCTGGT GAAGAAC AAGT GCGT GAACTTC A ACTTC AACGGACTGACCGGAAC AGGCGT GCTGACCGAGTCC A AC AAGAAGTT

CCTGCCTTTTCAGCAGTTCGGCAGGGACATCGCAGATACCACAGACGCCGTG

CGCGACCCTCAGACCCTGGAGATCCTGGACATCACACCATGCTCCTTCGGCG

GCGTGTCTGTGATCACACCAGGCACCAATACAAGCAACCAGGTGGCCGTGCT

GT ATC AGGACGT GAATTGT ACCGAGGT GCC AGT GGC AATCC ACGC AGAT C AG

CTGACCCCTACATGGCGGGTGTACTCTACCGGCAGCAACGTGTTCCAGACAA

GAGCCGGATGCCTGATCGGAGCAGAGCACGTGAACAATAGCTATGAGTGCGA

CATCCCTATCGGCGCCGGCATCTGTGCCTCCTACCAGACCCAGACAAACTCCC

CAAGGTCTGTGGGCGATACAGGCCTGTCCAAGAATCCAATCGAGCTGGTAGA

GGGCTGGTTCAGCAGTTGGAAAAGCTCCATCGCCTCCTTTTTCTTTATCATCG

GCCTGATCATCGGACTGTTCCTGGTGCTCCGCGTGGGTATCCACCTGTGCATC

A AGC T GA AGC AC AC C A AGA A A AGAC AGATTT AT AC AGAC ATCGAGAT GA AC

CGCCTGGGAAAGTGAGCTAGCCAGATTCTTCATGTTTGGACCAAATCAACTTG

TGATACCATGCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGA

AAAAAACTAACAGCAATCATGGAAGTCCACGATTTTGAGACCGACGAGTTCA

ATGATTTCAATGAAGATGACTATGCCACAAGAGAATTCCTGAATCCCGATGA

GCGCATGACGTACTTGAATCATGCTGATTACAATTTGAATTCTCCTCTAATTA

GTGATGATATTGACAATTTGATCAGGAAATTCAATTCTCTTCCGATTCCCTCG

ATGTGGGATAGTAAGAACTGGGATGGAGTTCTTGAGATGTTAACATCATGTC

A AGC C A AT C CC ATCTC A AC AT C TC AGAT GC AT A A AT GGAT GGGA AGTT GGTT

A AT GT C T GAT A AT CAT GAT GC C AGT C A AGGGT AT AGTTTTTT AC AT GA AGT GG

AC AA AGAGGC AGAAAT AAC ATTT GACGT GGT GGAGACCTT C ATCCGCGGCTG

GGGCAACAAACCAATTGAATACATCAAAAAGGAAAGATGGACTGACTCATTC

AAAATTCTCGCTTATTTGTGTCAAAAGTTTTTGGACTTACACAAGTTGACATT

AATCTTAAATGCTGTCTCTGAGGTGGAATTGCTCAACTTGGCGAGGACTTTCA

AAGGCAAAGTCAGAAGAAGTTCTCATGGAACGAACATATGCAGGATTAGGGT

TCCCAGCTTGGGTCCTACTTTTATTTCAGAAGGATGGGCTTACTTCAAGAAAC

TTGATATTCTAATGGACCGAAACTTTCTGTTAATGGTCAAAGATGTGATTATA

GGGAGGATGCAAACGGTGCTATCCATGGTATGTAGAATAGACAACCTGTTCT

CAGAGCAAGACATCTTCTCCCTTCTAAATATCTACAGAATTGGAGATAAAATT

GTGGAGAGGCAGGGAAATTTTTCTTATGACTTGATTAAAATGGTGGAACCGA

TATGCAACTTGAAGCTGATGAAATTAGCAAGAGAATCAAGGCCTTTAGTCCC

ACAATTCCCTCATTTTGAAAATCATATCAAGACTTCTGTTGATGAAGGGGCAA

AAATTGACCGAGGT AT AAGATTCCTCC AT GAT C AGAT AATGAGT GT GAAAAC AGTGGATCTCACACTGGTGATTTATGGATCGTTCAGACATTGGGGTCATCCTT

TTATAGATTATTACACTGGACTAGAAAAATTACATTCCCAAGTAACCATGAA

GAAAGATATTGATGTGTCATATGCAAAAGCACTTGCAAGTGATTTAGCTCGG

ATTGTTCTATTTCAACAGTTCAATGATCATAAAAAGTGGTTCGTGAATGGAGA

CTTGCTCCCTCATGATCATCCCTTTAAAAGTCATGTTAAAGAAAATACATGGC

CCACAGCTGCTCAAGTTCAAGATTTTGGAGATAAATGGCATGAACTTCCGCTG

ATTAAATGTTTTGAAATACCCGACTTACTAGACCCATCGATAATATACTCTGA

C A A A AGTC ATT C A AT GA AT AGGT C AGAGGT GTTGA A AC AT GTCCGA AT GA AT

CCGAACACTCCTATCCCTAGTAAAAAGGTGTTGCAGACTATGTTGGACACAA

AGGCTACCAATTGGAAAGAATTTCTTAAAGAGATTGATGAGAAGGGCTTAGA

TGATGAT GATCT AATT ATT GGTCTT AAAGGAAAGGAGAGGGAACTGAAGTTG

GCAGGTAGATTTTTCTCCCTAATGTCTTGGAAATTGCGAGAATACTTTGTAAT

TACCGAATATTTGATAAAGACTCATTTCGTCCCTATGTTTAAAGGCCTGACAA

TGGCGGACGATCTAACTGCAGTCATTAAAAAGATGTTAGATTCCTCATCCGGC

C AAGGATT GAAGT CAT ATGAGGC AATTT GC AT AGCC AAT C AC ATT GATT ACG

AAAAATGGAATAACCACCAAAGGAAGTTATCAAACGGCCCAGTGTTCCGAGT

TATGGGCCAGTTCTTAGGTTATCCATCCTTAATCGAGAGAACTCATGAATTTT

TT GAGAAAAGTCTT AT AT ACT AC AAT GGAAGACC AGACTTGAT GCGT GTT C A

CAACAACACACTGATCAATTCAACCTCCCAACGAGTTTGTTGGCAAGGACAA

G AGGGT GG AC T GG A AGGT C T AC GGC A A A A AGG AT GG AC T ATC C T C A AT C T AC

TGGTTATTCAAAGAGAGGCTAAAATCAGAAACACTGCTGTCAAAGTCTTGGC

ACAAGGTGATAATCAAGTTATTTGCACACAGTATAAAACGAAGAAATCGAGA

AACGTT GT AG AATT AC AGGGT GCTCTC AAT C AAAT GGTTTCT AAT AATGAGAA

AATT AT GACTGC AATC AA AAT AGGGAC AGGGAAGTT AGGACTTTT GAT AAAT

GACGATGAGACT AT GC AATCTGC AGATT ACTTGAATT AT GGAAAAAT ACCGA

TTTTCCGTGGAGTGATTAGAGGGTTAGAGACCAAGAGATGGTCACGAGTGAC

TTGTGTCACCAATGACCAAATACCCACTTGTGCTAATATAATGAGCTCAGTTT

CCACAAATGCTCTCACCGTAGCTCATTTTGCTGAGAACCCAATCAATGCCATG

ATACAGTACAATTATTTTGGGACATTTGCTAGACTCTTGTTGATGATGCATGA

TCCTGCTCTTCGTCAATCATTGTATGAAGTTCAAGATAAGATACCGGGCTTGC

ACAGTTCTACTTTCAAATACGCCATGTTGTATTTGGACCCTTCCATTGGAGGA

GTGTCGGGCATGTCTTTGTCCAGGTTTTTGATTAGAGCCTTCCCAGATCCCGT

AACAGAAAGTCTCTCATTCTGGAGATTCATCCATGTACATGCTCGAAGTGAGC

ATCTGAAGGAGAT GAGT GC AGT ATTTGGAAACCCCGAGAT AGCC AAGTTTCG AATAACTCACATAGACAAGCTAGTAGAAGATCCAACCTCTCTGAACATCGCT

ATGGGAATGAGTCCAGCGAACTTGTTAAAGACTGAGGTTAAAAAATGCTTAA

TCGAATCAAGACAAACCATCAGGAACCAGGTGATTAAGGATGCAACCATATA

TTTGTATCATGAAGAGGATCGGCTCAGAAGTTTCTTATGGTCAATAAATCCTC

TGTTCCCTAGATTTTTAAGTGAATTCAAATCAGGCACTTTTTTGGGAGTCGCA

GACGGGCTCATCAGTCTATTTCAAAATTCTCGTACTATTCGGAACTCCTTTAA

G A A A A AGT ATC AT AGGG A ATT GG AT GAT T T GAT TGT G AGG AGT G AGGT ATC C

TCTTTGAC AC ATTT AGGGAAACTTC ATTTGAGAAGGGGAT CAT GT AAAAT GT G

GACATGTTCAGCTACTCATGCTGACACATTAAGATACAAATCCTGGGGCCGT

ACAGTTATTGGGACAACTGTACCCCATCCATTAGAAATGTTGGGTCCACAAC

ATCGAAAAGAGACTCCTTGTGCACCATGTAACACATCAGGGTTCAATTATGTT

TCTGTGCATTGTCCAGACGGGATCCATGACGTCTTTAGTTCACGGGGACCATT

GCCTGCTTATCTAGGGTCTAAAACATCTGAATCTACATCTATTTTGCAGCCTT

GGGAAAGGGAAAGCAAAGTCCCACTGATTAAAAGAGCTACACGTCTTAGAG

ATGCTATCTCTTGGTTTGTTGAACCCGACTCTAAACTAGCAATGACTATACTT

TCTAACATCCACTCTTTAACAGGCGAAGAATGGACCAAAAGGCAGCATGGGT

TCAAAAGAACAGGGTCTGCCCTTCATAGGTTTTCGACATCTCGGATGAGCCAT

GGTGGGTTCGCATCTCAGAGCACTGCAGCATTGACCAGGTTGATGGCAACTA

CAGACACCATGAGGGATCTGGGAGATCAGAATTTCGACTTTTTATTCCAAGC

AACGTTGCTCTATGCTCAAATTACCACCACTGTTGCAAGAGACGGATGGATC

ACCAGTTGTACAGATCATTATCATATTGCCTGTAAGTCCTGTTTGAGACCCAT

AGAAGAGATCACCCTGGACTCAAGTATGGACTACACGCCCCCAGATGTATCC

CAT GT GC T G A AG AC AT GG AGG A AT GGGG A AGGT T C GT GGGG AC A AG AG AT A

AAACAGATCTATCCTTTAGAAGGGAATTGGAAGAATTTAGCACCTGCTGAGC

AATCCTATCAAGTCGGCAGATGTATAGGTTTTCTATATGGAGACTTGGCGTAT

AGAAAATCTACTCATGCCGAGGACAGTTCTCTATTTCCTCTATCTATACAAGG

TCGTATTAGAGGTCGAGGTTTCTTAAAAGGGTTGCTAGACGGATTAATGAGA

GCAAGTTGCTGCCAAGTAATACACCGGAGAAGTCTGGCTCATTTGAAGAGGC

CGGCCAACGCAGTGTACGGAGGTTTGATTTACTTGATTGATAAATTGAGTGTA

TCACCTCCATTCCTTTCTCTTACTAGATCAGGACCTATTAGAGACGAATTAGA

AACGATTCCCCACAAGATCCCAACCTCCTATCCGACAAGCAACCGTGATATG

GGGGTGATTGTCAGAAATTACTTCAAATACCAATGCCGTCTAATTGAAAAGG

GAAAATACAGATCACATTATTCACAATTATGGTTATTCTCAGATGTCTTATCC

ATAGACTTCATTGGACCATTCTCTATTTCCACCACCCTCTTGCAAATCCTATAC AAGCCATTTTTATCTGGGAAAGATAAGAATGAGTTGAGAGAGCTGGCAAATC

TTTCTTC ATT GCT AAGAT C AGGAGAGGGGTGGGAAGAC AT AC ATGT GAAATT

CTTCACCAAGGACATATTATTGTGTCCAGAGGAAATCAGACATGCTTGCAAG

TTCGGGATTGCTAAGGATAATAATAAAGACATGAGCTATCCCCCTTGGGGAA

GGGAATCCAGAGGGACAATTACAACAATCCCTGTTTATTATACGACCACCCC

TTACCCAAAGATGCTAGAGATGCCTCCAAGAATCCAAAATCCCCTGCTGTCC

GGAATCAGGTTGGGCCAATTACCAACTGGCGCTCATTATAAAATTCGGAGTA

TATTACATGGAATGGGAATCCATTACAGGGACTTCTTGAGTTGTGGAGACGG

CTCCGGAGGGAT GACTGCTGC ATT ACT ACGAGAAAAT GT GC AT AGC AGAGGA

ATATTCAATAGTCTGTTAGAATTATCAGGGTCAGTCATGCGAGGCGCCTCTCC

TGAGCCCCCCAGTGCCCTAGAAACTTTAGGAGGAGATAAATCGAGATGTGTA

AAT GGTGAAAC AT GTT GGGAAT ATCC ATCTGACTT AT GT GACCC AAGGACTT

GGGACTATTTCCTCCGACTCAAAGCAGGCTTGGGGCTTCAAATTGATTTAATT

GTAATGGATATGGAAGTTCGGGATTCTTCTACTAGCCTGAAAATTGAGACGA

ATGTTAGAAATTATGTGCACCGGATTTTGGATGAGCAAGGAGTTTTAATCTAC

A AG AC TT AT GGA AC AT AT ATTTGT GAG AGC GA A A AGA AT GC AGT A AC A AT C C

TTGGTCCCATGTTCAAGACGGTCGACTTAGTTCAAACAGAATTTAGTAGTTCT

C A A AC GT C T G A AGT AT AT AT GGT AT GT A A AGGTT T G A AG A A AT T AAT C GAT G

AACCCAATCCCGATTGGTCTTCCATCAATGAATCCTGGAAAAACCTGTACGCA

TTCCAGTCATCAGAACAGGAATTTGCCAGAGCAAAGAAGGTTAGTACATACT

TTACCTTGACAGGTATTCCCTCCCAATTCATTCCTGATCCTTTTGTAAACATTG

AGACTATGCTACAAATATTCGGAGTACCCACGGGTGTGTCTCATGCGGCTGCC

TTAAAATCATCTGATAGACCTGCAGATTTATTGACCATTAGCCTTTTTTATATG

GCGATT AT ATCGT ATT AT AAC AT C AAT CAT AT C AG AGT AGGACCGAT ACCTCC

GAACCCCCCATCAGATGGAATTGCACAAAATGTGGGGATCGCTATAACTGGT

ATAAGCTTTTGGCTGAGTTTGATGGAGAAAGACATTCCACTATATCAACAGTG

TTTAGCAGTTATCCAGCAATCATTCCCGATTAGGTGGGAGGCTGTTTCAGTAA

AAGGAGGAT AC AAGC AGAAGT GGAGT ACT AGAGGT GATGGGCTCCC AAAAG

ATACCCGAACTTCAGACTCCTTGGCCCCAATCGGGAACTGGATCAGATCTCTG

GAATTGGTCCGAAACCAAGTTCGTCTAAATCCATTCAATGAGATCTTGTTCAA

T C AGCT AT GTCGT AC AGTGGAT AAT C ATTT GAAAT GGT C AAATTT GCGA AGAA

AC AC AGGAAT GATT GAAT GGAT C AAT AGACGAATTTC AAAAGAAGACCGGT C

T AT AC T GAT GT T G A AG AGT G AC C T AC AC G AGG A A A AC TC TT GG AG AG AT T A A AAAATCATGAGGAGACTCCAAACTTTAAGTATGAAAAAAACTTTGATCCTTA

AGACCCTCTTGTGGTTTTTATTTTTTATCTGGTTTTGTGGTCTTCGT.

In another embodiment, the nucleic acid comprises the sequence of SEQ ID NO: 19, shown below (VSV vector: Convac VI South Africa):

ACGAAGAC AAAC AAACC ATT ATT AT C ATT AAAAGGCTC AGGAGAAACTTT AA

C AGT AAT C AAA ATGTCTGTT AC AGTC AAGAGAAT C ATTGAC AAC AC AGTC AT

AGTTCCAAAACTTCCTGCAAATGAGGATCCAGTGGAATACCCGGCAGATTAC

TTCAGAAAATCAAAGGAGATTCCTCTTTACATCAATACTACAAAAAGTTTGTC

AGATCTAAGAGGATATGTCTACCAAGGCCTCAAATCCGGAAATGTATCAATC

AT AC AT GT C A AC AGC T AC TT GT AT GG AGC ATT A A AGG AC ATC C GGGGT A AGT

TGGATAAAGATTGGTCAAGTTTCGGAATAAACATCGGGAAAGCAGGGGATAC

AATCGGAATATTTGACCTTGTATCCTTGAAAGCCCTGGACGGCGTACTTCCAG

AT GGAGT ATCGGAT GCTTCC AGAACC AGCGC AGAT GAC AAAT GGTT GCCTTT

GTATCTACTTGGCTTATACAGAGTGGGCAGAACACAAATGCCTGAATACAGA

A A A A AGC TC AT GGAT GGGC T GAC A A AT C A AT GCA A A AT GAT C A AT GA AC AGT

TTGAACCTCTTGTGCCAGAAGGTCGTGACATTTTTGATGTGTGGGGAAATGAC

AGTAATTACACAAAAATTGTCGCTGCAGTGGACATGTTCTTCCACATGTTCAA

AAAACATGAATGTGCCTCGTTCAGATACGGAACTATTGTTTCCAGATTCAAAG

ATTGTGCTGCATTGGCAACATTTGGACACCTCTGCAAAATAACCGGAATGTCT

ACAGAAGATGTAACGACCTGGATCTTGAACCGAGAAGTTGCAGATGAAATGG

TCCAAATGATGCTTCCAGGCCAAGAAATTGACAAGGCCGATTCATACATGCC

TTATTTGATCGACTTTGGATTGTCTTCTAAGTCTCCATATTCTTCCGTCAAAAA

CCCTGCCTTCCACTTCTGGGGGCAATTGACAGCTCTTCTGCTCAGATCCACCA

GAGCAAGGAATGCCCGACAGCCTGATGACATTGAGTATACATCTCTTACTAC

AGCAGGTTTGTTGTACGCTTATGCAGTAGGATCCTCTGCCGACTTGGCACAAC

AGTTTTGTGTTGGAGATAACAAATACACTCCAGATGATAGTACCGGAGGATT

GACGACTAATGCACCGCCACAAGGCAGAGATGTGGTCGAATGGCTCGGATGG

T TT G A AG AT C A A A AC AG A A A AC C GAC TC C T GAT AT GAT GC AGT AT GC G A A A A

GAGCAGTCATGTCACTGCAAGGCCTAAGAGAGAAGACAATTGGCAAGTATGC

TAAGTCAGAATTTGACAAATGACCCTATAATTCTCAGATCACCTATTATATAT

TATGCTACATATGAAAAAAACTAACAGATATCATGGATAATCTCACAAAAGT

TCGTGAGTATCTCAAGTCCTATTCTCGTCTGGATCAGGCGGTAGGAGAGATAG

ATGAGATCGAAGCACAACGAGCTGAAAAGTCCAATTATGAGTTGTTCCAAGA

GGATGGAGTGGAAGAGCATACTAAGCCCTCTTATTTTCAGGCAGCAGATGAT TCTGAC AC AGA AT C T GA AC C AG A A ATT GA AG AC A AT C A AGGTTT GT AT GC AC

CAGATCCAGAAGCTGAGCAAGTTGAAGGCTTTATACAGGGGCCTTTAGATGA

CT AT GC AGAT GAGGAAGT GGAT GTT GT ATTT ACTTCGGACTGGAAAC AGCCT

GAGCTTGAATCTGACGAGCATGGAAAGACCTTACGGTTGACATCGCCAGAGG

GTTTAAGTGGAGAGCAGAAATCCCAGTGGCTTTCGACGATTAAAGCAGTCGT

GC AAAGTGCC AAAT ACTGGAATCTGGC AGAGT GC AC ATTTGAAGC ATCGGGA

G A AGGGGT C AT T AT G A AGG AGC GC C AG AT A AC T C C GGAT GT AT AT A AGGT C A

CTCCAGTGATGAACACACATCCGTCCCAATCAGAAGCAGTATCAGATGTTTG

GTCTCTCTCAAAGACATCCATGACTTTCCAACCCAAGAAAGCAAGTCTTCAGC

CTCTCACCATATCCTTGGATGAATTGTTCTCATCTAGAGGAGAGTTCATCTCT

GTCGGAGGTGACGGACGAATGTCTCATAAAGAGGCCATCCTGCTCGGCCTGA

GATACAAAAAGTTGTACAATCAGGCGAGAGTCAAATATTCTCTGTAGACTAT

GAAAAAAAGTAACAGATATCACGATCTAAGTGTTATCCCAATCCATTCATCA

T G AGTT C C TT A A AG A AG AT TC TC GGT C T G A AGGGG A A AGGT A AG A A AT C T A A

GAAATTAGGGATCGCACCACCCCCTTATGAAGAGGACACTAGCATGGAGTAT

GCTCCGAGCGCTCCAATTGACAAATCCTATTTTGGAGTTGACGAGATGGACA

CCTATGATCCGAATCAATTAAGATATGAGAAATTCTTCTTTACAGTGAAAATG

ACGGTTAGATCTAATCGTCCGTTCAGAACATACTCAGATGTGGCAGCCGCTGT

ATCCCATTGGGATCACATGTACATCGGAATGGCAGGGAAACGTCCCTTCTAC

AAAATCTTGGCTTTTTTGGGTTCTTCTAATCTAAAGGCCACTCCAGCGGTATT

GGCAGATCAAGGTCAACCAGAGTATCACACTCACTGCGAAGGCAGGGCTTAT

TTGCCACATAGGATGGGGAAGACCCCTCCCATGCTCAATGTACCAGAGCACT

T C AGAAGACC ATTC AAT AT AGGTCTTT AC AAGGGAACGATTGAGCTC AC A AT

GACCATCTACGATGATGAGTCACTGGAAGCAGCTCCTATGATCTGGGATCATT

TCAATTCTTCCAAATTTTCTGATTTCAGAGAGAAGGCCTTAATGTTTGGCCTG

ATTGTCGAGAAAAAGGCATCTGGAGCGTGGGTCCTGGATTCTATCAGCCACT

TCAAATGAGCTAGTCTAACTTCTAGCTTCTGAACAATCCCCGGTTTACTCAGT

CTCTCCTAATTCCAGCCTCTCGAACAACTAATATCCTGTCTTTTCTATCCCTAT

GAAAAAAACTAACAGAGATCGATCTGTTTACGCGTCACTATGAAGTGCCTTTT

GTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCC

ACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGC

CCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCATAC

A AGT C A A A AT GCC C A AGAGTC AC A AGGC T ATT C A AGC AGACGGTT GGAT GT G

TCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGT ATATAACACAGTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGA

AAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCT

C AAAGTT GTGGAT AT GC AACTGT GACGGAT GCCGAAGC AGT GATTGTCC AGG

TGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCA

CAGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTC

TACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCA

TTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGA

AAGGAGGGC AC AGGGTT C AGAAGT AACT ACTTTGCTT AT GAAACTGGAGGC A

AGGCCTGC AAAAT GC AAT ACTGC AAGC ATT GGGGAGTC AGACTCCC ATC AGG

TGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTG

AATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTA

AGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAAC

CTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATC

TTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACC

CTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCT

C T C A AG A AT GGT C GG A AT GAT C AGT GG A AC T AC C AC AG A A AGGG A AC TGT GG

GAT GACTGGGC ACC AT AT GAAGACGT GGAAATTGGACCC AAT GGAGTTCTGA

GGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTG

GACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACAT

TCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATA

CTGGGCT ATCC AAAAATCC AATCGAGCTTGT AGAAGGTT GGTTC AGT AGTT G

GAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATT

CTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGA

AAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACTCAA

ATCCTGCTAGGTATGAAAAAAACTAACaGATATCACGCTCGAGCCACCATGTT

CGTGTTTCTGGTGCTGCTGCCTCTGGTGAGCTCCCAGTGCGTGAACTTCACCA

CAAGGACCCAGCTGCCCCCTGCCTATACCAATTCCTTCACACGGGGCGTGTAC

TATCCCGACAAGGTGTTCCGGAGCAGCGTGCTGCACTCCACACAGGATCTGTT

TCTGCCTTTCTTTTCTAACGTGACCTGGTTCCACGCCATCCACGTGAGCGGCA

CCAATGGCACAAAGCGGTTCGCCAATCCAGTGCTGCCCTTTAACGATGGCGT

GTACTTCGCCTCCACCGAGAAGTCTAACATCATCAGAGGCTGGATCTTTGGCA

CCACACTGGACAGCAAGACACAGTCCCTGCTGATCGTGAACAATGCCACCAA

CGTGGTCATCAAGGTGTGCGAGTTCCAGTTTTGTAATGATCCATTCCTGGGCG

TGTACTATCACAAGAACAATAAGTCTTGGATGGAGAGCGAGTTTCGCGTGTA TTCCTCTGCCAACAATTGCACATTTGAGTACGTGTCCCAGCCCTTCCTGATGG

ACCTGGAGGGCAAGCAGGGCAATTTCAAGAACCTGAGGGAGTTCGTGTTTAA

GAATATCGATGGCTACTTCAAAATCTACTCCAAGCACACCCCAATCAACCTG

GTGCGCGGCCTGCCACAGGGCTTCTCTGCCCTGGAGCCACTGGTGGATCTGCC

CATCGGCATCAACATCACCCGGTTTCAGACACTGCTGGCCCTGCACAGAAGC

TACCTGACACCAGGCGACAGCTCCTCTGGATGGACCGCAGGAGCAGCAGCCT

ACTATGTGGGCTATCTGCAGCCCAGGACCTTCCTGCTGAAGTACAACGAGAA

TGGCACCATCACAGACGCCGTGGATTGCGCCCTGGATCCCCTGTCTGAGACC

AAGTGTACACTGAAGAGCTTTACCGTGGAGAAGGGCATCTATCAGACAAGCA

ATTTCAGGGTGCAGCCTACCGAGTCCATCGTGCGCTTTCCCAATATCACAAAC

CTGTGCCCTTTTGGCGAGGTGTTCAACGCAACCCGCTTCGCCAGCGTGTACGC

CTGGAATAGGAAGCGCATCTCCAACTGCGTGGCCGACTATTCTGTGCTGTACA

ACAGCGCCTCCTTCTCTACCTTTAAGTGCTATGGCGTGAGCCCCACAAAGCTG

AATGACCTGTGCTTTACCAACGTGTACGCCGATTCCTTCGTGATCAGGGGCGA

CGAGGTGCGCCAGATCGCACCAGGACAGACAGGCAATATCGCAGACTACAAT

TATAAGCTGCCTGACGATTTCACCGGCTGCGTGATCGCCTGGAACTCTAACAA

TCTGGATAGCAAAGTGGGCGGCAACTACAATTATCTGTACCGGCTGTTTAGA

AAGTCTAATCTGAAGCCATTCGAGAGGGACATCTCCACAGAAATCTACCAGG

CCGGCTCTACCCCCTGCAATGGCGTGAAGGGCTTTAACTGTTATTTCCCTCTG

CAGAGCTACGGCTTCCAGCCAACATATGGCGTGGGCTATCAGCCCTACCGCG

TGGTGGTGCTGTCTTTTGAGCTGCTGCACGCACCTGCAACAGTGTGCGGACCA

AAGAAGAGCACCAATCTGGTGAAGAACAAGTGCGTGAACTTCAACTTCAACG

GACTGACCGGAACAGGCGTGCTGACCGAGTCCAACAAGAAGTTCCTGCCTTT

TCAGCAGTTCGGCAGGGACATCGCAGATACCACAGACGCCGTGCGCGACCCT

CAGACCCTGGAGATCCTGGACATCACACCATGCTCCTTCGGCGGCGTGTCTGT

GATCACACCAGGCACCAATACAAGCAACCAGGTGGCCGTGCTGTATCAGGGC

GTGAATTGTACCGAGGTGCCAGTGGCAATCCACGCAGATCAGCTGACCCCTA

CAT GGCGGGTGT ACTCT ACCGGC AGC AACGT GTTCC AGAC AAGAGCCGGATG

CCTGATCGGAGCAGAGCACGTGAACAATAGCTATGAGTGCGACATCCCTATC

GGCGCCGGCATCTGTGCCTCCTACCAGACCCAGACAAACTCCCCAAGGTCTG

T GGGCGAT AC AGGC CTGTCC A AGA AT C C A ATCGAGC T GGT AGAGGGC T GGTT

CAGCAGTTGGAAAAGCTCCATCGCCTCCTTTTTCTTTATCATCGGCCTGATCA

TCGGACTGTTCCTGGTGCTCCGCGTGGGTATCCACCTGTGCATCAAGCTGAAG

CACACCAAGAAAAGACAGATTTATACAGACATCGAGATGAACCGCCTGGGA AAGTGAGCTAGCCAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCAT

GCTCAAAGAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAACTA

ACAGCAATCATGGAAGTCCACGATTTTGAGACCGACGAGTTCAATGATTTCA

AT GA AGAT GAC T AT GC C AC A AG AGA ATTCC T GA ATCC CGAT GAGC GC AT GAC

GTACTTGAATCATGCTGATTACAATTTGAATTCTCCTCTAATTAGTGATGATAT

TGACAATTTGATCAGGAAATTCAATTCTCTTCCGATTCCCTCGATGTGGGATA

GT A AGA ACTGGGAT GGAGTTC TT GAG AT GTT A AC AT CAT GT C A AGC C A AT C C

CATCTCAACATCTCAGATGCATAAATGGATGGGAAGTTGGTTAATGTCTGATA

AT CAT GAT GC C AGT C A AGGGT AT AGTTTTTT AC AT GA AGT GG AC A A AGAGGC

AGAAATAACATTTGACGTGGTGGAGACCTTCATCCGCGGCTGGGGCAACAAA

CCA ATT GA AT AC AT C A A A A AGG A A AGAT GGAC T GAC TC ATT C A A A ATTC TC G

CTTATTTGTGTCAAAAGTTTTTGGACTTACACAAGTTGACATTAATCTTAAAT

GCTGTCTCTGAGGTGGAATTGCTCAACTTGGCGAGGACTTTCAAAGGCAAAG

TCAGAAGAAGTTCTCATGGAACGAACATATGCAGGATTAGGGTTCCCAGCTT

GGGTCCTACTTTTATTTCAGAAGGATGGGCTTACTTCAAGAAACTTGATATTC

T A AT GGAC C G A A AC TTTCTGTT A AT GGT C A A AG AT GT GAT TAT AGGG AGG AT

GCA A AC GGT GCT AT C CAT GGT AT GT AGA AT AGAC A AC CTGTTCTC AGAGC A A

GACATCTTCTCCCTTCTAAATATCTACAGAATTGGAGATAAAATTGTGGAGAG

GCAGGGAAATTTTTCTTATGACTTGATTAAAATGGTGGAACCGATATGCAACT

T GAAGCTGAT GAAATT AGC AAGAGAAT C AAGGCCTTT AGTCCC AC AATTCCC

TCATTTTGAAAATCATATCAAGACTTCTGTTGATGAAGGGGCAAAAATTGACC

GAGGT AT A AG ATTCC TCC AT GAT C AGAT A AT GAGT GT GA A A AC AGT GGAT C T

CACACTGGTGATTTATGGATCGTTCAGACATTGGGGTCATCCTTTTATAGATT

ATTACACTGGACTAGAAAAATTACATTCCCAAGTAACCATGAAGAAAGATAT

TGATGTGTCATATGCAAAAGCACTTGCAAGTGATTTAGCTCGGATTGTTCTAT

TTCAACAGTTCAATGATCATAAAAAGTGGTTCGTGAATGGAGACTTGCTCCCT

CATGATCATCCCTTTAAAAGTCATGTTAAAGAAAATACATGGCCCACAGCTG

CTCAAGTTCAAGATTTTGGAGATAAATGGCATGAACTTCCGCTGATTAAATGT

TTTGAAATACCCGACTTACTAGACCCATCGATAATATACTCTGACAAAAGTCA

TTC AAT GAAT AGGT C AGAGGT GTTGAAAC AT GTCCGAAT GAATCCGAAC ACT

CCTATCCCTAGTAAAAAGGTGTTGCAGACTATGTTGGACACAAAGGCTACCA

ATTGGAAAGAATTTCTTAAAGAGATTGATGAGAAGGGCTTAGATGATGATGA

TCT A ATT ATT GGT C TT A A AGG A A AGG AG AGGG A AC T GA AGTT GGC AGGT AGA

TTTTTCTCCCTAATGTCTTGGAAATTGCGAGAATACTTTGTAATTACCGAATAT TTGATAAAGACTCATTTCGTCCCTATGTTTAAAGGCCTGACAATGGCGGACGA

TCTAACTGCAGTCATTAAAAAGATGTTAGATTCCTCATCCGGCCAAGGATTGA

AGT CAT ATGAGGC AATTT GC AT AGCC AATC AC ATTGATT ACGAAA AATGGA A

TAACCACCAAAGGAAGTTATCAAACGGCCCAGTGTTCCGAGTTATGGGCCAG

TTCTTAGGTTATCCATCCTTAATCGAGAGAACTCATGAATTTTTTGAGAAAAG

TCTTATATACTACAATGGAAGACCAGACTTGATGCGTGTTCACAACAACACA

CTGATCAATTCAACCTCCCAACGAGTTTGTTGGCAAGGACAAGAGGGTGGAC

TGGAAGGTCTACGGCAAAAAGGATGGACTATCCTCAATCTACTGGTTATTCA

A AGAGAGGCT A A A ATC AGA A AC AC T GC T GT C A A AGT C TT GGC AC A AGGT GAT

AAT C AAGTT ATTT GC AC AC AGT AT AAAACGAAGAAATCGAGAAACGTTGT AG

AATTACAGGGTGCTCTCAATCAAATGGTTTCTAATAATGAGAAAATTATGACT

GCA AT C A A A AT AGGG AC AGGG AAGTT AGGAC TTTT GAT A A AT GACGAT GAGA

CTATGCAATCTGCAGATTACTTGAATTATGGAAAAATACCGATTTTCCGTGGA

GTGATTAGAGGGTTAGAGACCAAGAGATGGTCACGAGTGACTTGTGTCACCA

ATGACCAAATACCCACTTGTGCTAATATAATGAGCTCAGTTTCCACAAATGCT

CTCACCGTAGCTCATTTTGCTGAGAACCCAATCAATGCCATGATACAGTACAA

TTATTTTGGGACATTTGCTAGACTCTTGTTGATGATGCATGATCCTGCTCTTCG

TCAATCATTGTATGAAGTTCAAGATAAGATACCGGGCTTGCACAGTTCTACTT

TCAAATACGCCATGTTGTATTTGGACCCTTCCATTGGAGGAGTGTCGGGCATG

TCTTTGTCCAGGTTTTTGATTAGAGCCTTCCCAGATCCCGTAACAGAAAGTCT

CTCATTCTGGAGATTCATCCATGTACATGCTCGAAGTGAGCATCTGAAGGAG

ATGAGTGCAGTATTTGGAAACCCCGAGATAGCCAAGTTTCGAATAACTCACA

TAGACAAGCTAGTAGAAGATCCAACCTCTCTGAACATCGCTATGGGAATGAG

TCCAGCGAACTTGTTAAAGACTGAGGTTAAAAAATGCTTAATCGAATCAAGA

CAAACCATCAGGAACCAGGTGATTAAGGATGCAACCATATATTTGTATCATG

AAGAGGATCGGCTCAGAAGTTTCTTATGGTCAATAAATCCTCTGTTCCCTAGA

TTTTTAAGTGAATTCAAATCAGGCACTTTTTTGGGAGTCGCAGACGGGCTCAT

CAGTCTATTTCAAAATTCTCGTACTATTCGGAACTCCTTTAAGAAAAAGTATC

AT AGGGAATT GGAT GATTT GATTGT GAGGAGT GAGGT ATCCTCTTT GAC AC AT

TT AGGGA A ACTT C ATTT GAGA AGGGGAT CAT GT A A A AT GT GGAC AT GTT C AG

CTACTCATGCTGACACATTAAGATACAAATCCTGGGGCCGTACAGTTATTGGG

ACAACTGTACCCCATCCATTAGAAATGTTGGGTCCACAACATCGAAAAGAGA

CTCCTTGTGCACCATGTAACACATCAGGGTTCAATTATGTTTCTGTGCATTGTC

CAGACGGGATCCATGACGTCTTTAGTTCACGGGGACCATTGCCTGCTTATCTA GGGTCT AAAAC ATCTGAATCT AC ATCT ATTTT GC AGCCTTGGGAA AGGGAAA

GCAAAGTCCCACTGATTAAAAGAGCTACACGTCTTAGAGATGCTATCTCTTGG

TTTGTTGAACCCGACTCTAAACTAGCAATGACTATACTTTCTAACATCCACTC

TTTAACAGGCGAAGAATGGACCAAAAGGCAGCATGGGTTCAAAAGAACAGG

GTCTGCCCTTCATAGGTTTTCGACATCTCGGATGAGCCATGGTGGGTTCGCAT

CTCAGAGCACTGCAGCATTGACCAGGTTGATGGCAACTACAGACACCATGAG

GGATCTGGGAGATCAGAATTTCGACTTTTTATTCCAAGCAACGTTGCTCTATG

CTCAAATTACCACCACTGTTGCAAGAGACGGATGGATCACCAGTTGTACAGA

TCATTATCATATTGCCTGTAAGTCCTGTTTGAGACCCATAGAAGAGATCACCC

TGGACTCAAGTATGGACTACACGCCCCCAGATGTATCCCATGTGCTGAAGAC

AT GGAGGAAT GGGGAAGGTTCGT GGGGAC A AGAGAT A AAAC AGATCT ATCC

TTT AGAAGGGAATTGGAAGAATTT AGC ACCTGCTGAGC AATCCT AT C AAGT C

GGCAGATGTATAGGTTTTCTATATGGAGACTTGGCGTATAGAAAATCTACTCA

TGCCGAGGACAGTTCTCTATTTCCTCTATCTATACAAGGTCGTATTAGAGGTC

GAGGTTTCTTAAAAGGGTTGCTAGACGGATTAATGAGAGCAAGTTGCTGCCA

AGTAATACACCGGAGAAGTCTGGCTCATTTGAAGAGGCCGGCCAACGCAGTG

TACGGAGGTTTGATTTACTTGATTGATAAATTGAGTGTATCACCTCCATTCCTT

TCTCTTACTAGATCAGGACCTATTAGAGACGAATTAGAAACGATTCCCCACA

AGATCCCAACCTCCTATCCGACAAGCAACCGTGATATGGGGGTGATTGTCAG

AAATTACTTCAAATACCAATGCCGTCTAATTGAAAAGGGAAAATACAGATCA

CATTATTCACAATTATGGTTATTCTCAGATGTCTTATCCATAGACTTCATTGGA

CCATTCTCTATTTCCACCACCCTCTTGCAAATCCTATACAAGCCATTTTTATCT

GGGAAAGAT AAGAATGAGTT GAGAGAGCTGGC AAATCTTTCTTC ATT GCT AA

GAT C AGGAG AGGGGT GGGA AGAC AT AC AT GT GA A ATTCTT C AC C A AGG AC AT

ATTATTGTGTCCAGAGGAAATCAGACATGCTTGCAAGTTCGGGATTGCTAAG

GAT AAT A AT A A AG AC AT GAGCT ATCCCCCTTGGGGAAGGGAATCC AGAGGGA

CAATTACAACAATCCCTGTTTATTATACGACCACCCCTTACCCAAAGATGCTA

GAGATGCCTCCAAGAATCCAAAATCCCCTGCTGTCCGGAATCAGGTTGGGCC

AATTACCAACTGGCGCTCATTATAAAATTCGGAGTATATTACATGGAATGGG

AATCC ATT AC AGGGACTTCTT GAGTTGT GGAGACGGCTCCGGAGGGAT GACT

GCTGCATTACTACGAGAAAATGTGCATAGCAGAGGAATATTCAATAGTCTGT

TAGAATTATCAGGGTCAGTCATGCGAGGCGCCTCTCCTGAGCCCCCCAGTGCC

C T AG A A AC TTT AGG AGG AG AT A A AT C GAG AT GT GT A A AT GGT G A A AC AT GT T

GGGAATATCCATCTGACTTATGTGACCCAAGGACTTGGGACTATTTCCTCCGA CTC AAAGC AGGCTTGGGGCTTC AAATTGATTT AATTGT AATGGAT AT GGAAGT

TCGGGATTCTTCTACTAGCCTGAAAATTGAGACGAATGTTAGAAATTATGTGC

ACCGGATTTTGGATGAGCAAGGAGTTTTAATCTACAAGACTTATGGAACATAT

ATTTGTGAGAGCGAAAAGAATGCAGTAACAATCCTTGGTCCCATGTTCAAGA

CGGTCGACTTAGTTCAAACAGAATTTAGTAGTTCTCAAACGTCTGAAGTATAT

ATGGTATGTAAAGGTTTGAAGAAATTAATCGATGAACCCAATCCCGATTGGT

CTTCCATCAATGAATCCTGGAAAAACCTGTACGCATTCCAGTCATCAGAACA

GGAATTTGCCAGAGCAAAGAAGGTTAGTACATACTTTACCTTGACAGGTATT

CCCTCCCAATTCATTCCTGATCCTTTTGTAAACATTGAGACTATGCTACAAAT

ATTCGGAGTACCCACGGGTGTGTCTCATGCGGCTGCCTTAAAATCATCTGATA

GACCTGCAGATTTATTGACCATTAGCCTTTTTTATATGGCGATTATATCGTATT

ATAACATCAATCATATCAGAGTAGGACCGATACCTCCGAACCCCCCATCAGA

TGGAATTGCACAAAATGTGGGGATCGCTATAACTGGTATAAGCTTTTGGCTGA

GTTTGATGGAGAAAGACATTCCACTATATCAACAGTGTTTAGCAGTTATCCAG

C AAT C ATTCCCGATT AGGT GGGAGGCTGTTT C AGT AAAAGGAGGAT AC AAGC

AGAAGT GGAGT ACT AGAGGT GAT GGGCTCCC AAAAGAT ACCCGAACTTC AGA

CTCCTTGGCCCCAATCGGGAACTGGATCAGATCTCTGGAATTGGTCCGAAACC

AAGTTCGTCTAAATCCATTCAATGAGATCTTGTTCAATCAGCTATGTCGTACA

GT GGAT AAT C ATTTG A A AT GGT C A A ATTTGC GA AGA A AC AC AGGA AT GATT G

AAT GGAT C AAT AGACGAATTT C AAAAGAAGACCGGTCT AT ACTGAT GTT GAA

GAGTGACCTACACGAGGAAAACTCTTGGAGAGATTAAAAAATCATGAGGAG

ACTCCAAACTTTAAGTATGAAAAAAACTTTGATCCTTAAGACCCTCTTGTGGT

TTTTATTTTTTATCTGGTTTTGTGGTCTTCGT.

In some embodiments, the nucleic acid comprises the sequence of SEQ ID NO:

20, shown below (VSV vector: Convac V2 China):

ACGAAGAC AAAC AAACC ATT ATT AT C ATT AAAAGGCTC AGGAGAAACTTT AA C AGT AAT C AAA ATGTCTGTT AC AGTC AAGAGAAT C ATTGAC AAC AC AGTC AT AGTTCCAAAACTTCCTGCAAATGAGGATCCAGTGGAATACCCGGCAGATTAC TTCAGAAAATCAAAGGAGATTCCTCTTTACATCAATACTACAAAAAGTTTGTC AGATCTAAGAGGATATGTCTACCAAGGCCTCAAATCCGGAAATGTATCAATC AT AC AT GT C A AC AGC T AC TT GT AT GG AGC ATT A A AGG AC ATC C GGGGT A AGT T GGAT A A AG AT T GGT C A AGTT T C GG A AT AAAC ATC GGG A A AGC AGGGG AT AC AATCGGAATATTTGACCTTGTATCCTTGAAAGCCCTGGACGGCGTACTTCCAG AT GGAGT ATCGG AT GCTTCC AGAACC AGCGC AGAT GAC AAAT GGTT GCCTTT GT AT C T AC TT GGCTT AT AC AGAGT GGGC AG A AC AC A A AT GCC T GA AT AC AGA

A A A A AGC TC AT GGAT GGGC T GAC A A AT C A AT GCA A A AT GAT C A AT GA AC AGT

TTGAACCTCTTGTGCCAGAAGGTCGTGACATTTTTGATGTGTGGGGAAATGAC

AGTAATTACACAAAAATTGTCGCTGCAGTGGACATGTTCTTCCACATGTTCAA

AAAACATGAATGTGCCTCGTTCAGATACGGAACTATTGTTTCCAGATTCAAAG

ATTGTGCTGCATTGGCAACATTTGGACACCTCTGCAAAATAACCGGAATGTCT

ACAGAAGATGTAACGACCTGGATCTTGAACCGAGAAGTTGCAGATGAAATGG

TCCAAATGATGCTTCCAGGCCAAGAAATTGACAAGGCCGATTCATACATGCC

TTATTTGATCGACTTTGGATTGTCTTCTAAGTCTCCATATTCTTCCGTCAAAAA

CCCTGCCTTCCACTTCTGGGGGCAATTGACAGCTCTTCTGCTCAGATCCACCA

GAGCAAGGAATGCCCGACAGCCTGATGACATTGAGTATACATCTCTTACTAC

AGCAGGTTTGTTGTACGCTTATGCAGTAGGATCCTCTGCCGACTTGGCACAAC

AGTTTTGTGTTGGAGATAACAAATACACTCCAGATGATAGTACCGGAGGATT

GACGACTAATGCACCGCCACAAGGCAGAGATGTGGTCGAATGGCTCGGATGG

T TT G A AG AT C A A A AC AG A A A AC C GAC TC C T GAT AT GAT GC AGT AT GC G A A A A

GAGCAGTCATGTCACTGCAAGGCCTAAGAGAGAAGACAATTGGCAAGTATGC

TAAGTCAGAATTTGACAAATGACCCTATAATTCTCAGATCACCTATTATATAT

TATGCTACATATGAAAAAAACTAACAGATATCATGGATAATCTCACAAAAGT

TCGTGAGTATCTCAAGTCCTATTCTCGTCTGGATCAGGCGGTAGGAGAGATAG

ATGAGATCGAAGCACAACGAGCTGAAAAGTCCAATTATGAGTTGTTCCAAGA

GGATGGAGTGGAAGAGCATACTAAGCCCTCTTATTTTCAGGCAGCAGATGAT

TCTGAC AC AGA AT C T GA AC C AGA A ATT GA AG AC A AT C A AGGTTT GT AT GC AC

CAGATCCAGAAGCTGAGCAAGTTGAAGGCTTTATACAGGGGCCTTTAGATGA

CT AT GC AGAT GAGGAAGT GGAT GTT GT ATTT ACTTCGGACTGGAAAC AGCCT

GAGCTTGAATCTGACGAGCATGGAAAGACCTTACGGTTGACATCGCCAGAGG

GTTTAAGTGGAGAGCAGAAATCCCAGTGGCTTTCGACGATTAAAGCAGTCGT

GC AAAGTGCC AAAT ACTGGAATCTGGC AGAGT GC AC ATTTGAAGC ATCGGGA

G A AGGGGT C AT T AT G A AGG AGC GC C AG AT A AC T C C GGAT GT AT AT A AGGT C A

CTCCAGTGATGAACACACATCCGTCCCAATCAGAAGCAGTATCAGATGTTTG

GTCTCTCTCAAAGACATCCATGACTTTCCAACCCAAGAAAGCAAGTCTTCAGC

CTCTCACCATATCCTTGGATGAATTGTTCTCATCTAGAGGAGAGTTCATCTCT

GTCGGAGGTGACGGACGAATGTCTCATAAAGAGGCCATCCTGCTCGGCCTGA

GATACAAAAAGTTGTACAATCAGGCGAGAGTCAAATATTCTCTGTAGACTAT

GAAAAAAAGTAACAGATATCACGATCTAAGTGTTATCCCAATCCATTCATCA T G AGTT C C TT A A AG A AG AT TC TC GGT C T G A AGGGG A A AGGT A AG A A AT C T A A

GAAATTAGGGATCGCACCACCCCCTTATGAAGAGGACACTAGCATGGAGTAT

GCTCCGAGCGCTCCAATTGACAAATCCTATTTTGGAGTTGACGAGATGGACA

CCTATGATCCGAATCAATTAAGATATGAGAAATTCTTCTTTACAGTGAAAATG

ACGGTTAGATCTAATCGTCCGTTCAGAACATACTCAGATGTGGCAGCCGCTGT

ATCCCATTGGGATCACATGTACATCGGAATGGCAGGGAAACGTCCCTTCTAC

AAAATCTTGGCTTTTTTGGGTTCTTCTAATCTAAAGGCCACTCCAGCGGTATT

GGCAGATCAAGGTCAACCAGAGTATCACACTCACTGCGAAGGCAGGGCTTAT

TTGCCACATAGGATGGGGAAGACCCCTCCCATGCTCAATGTACCAGAGCACT

T C AGAAGACC ATTC AAT AT AGGTCTTT AC AAGGGAACGATTGAGCTC AC A AT

GACCATCTACGATGATGAGTCACTGGAAGCAGCTCCTATGATCTGGGATCATT

TCAATTCTTCCAAATTTTCTGATTTCAGAGAGAAGGCCTTAATGTTTGGCCTG

ATTGTCGAGAAAAAGGCATCTGGAGCGTGGGTCCTGGATTCTATCAGCCACT

TCAAATGAGCTAGTCTAACTTCTAGCTTCTGAACAATCCCCGGTTTACTCAGT

CTCTCCTAATTCCAGCCTCTCGAACAACTAATATCCTGTCTTTTCTATCCCTAT

GAAAAAAACTAACAGAGATCGATCTGTTTACGCGTCACTATGAAGTGCCTTTT

GTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCC

ACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGC

CCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCATAC

A AGT C A A A AT GCC C A AGAGTC AC A AGGC T ATT C A AGC AGACGGTT GGAT GT G

TCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGT

ATATAACACAGTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGA

AAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCT

C AAAGTT GTGGAT AT GC AACTGT GACGGAT GCCGAAGC AGT GATTGTCC AGG

TGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCA

CAGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTC

TACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCA

TTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGA

AAGGAGGGC AC AGGGTT C AGAAGT AACT ACTTTGCTT AT GAAACTGGAGGC A

AGGCCTGC AAAAT GC AAT ACTGC AAGC ATT GGGGAGTC AGACTCCC ATC AGG

TGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTG

AATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTA

AGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAAC

CTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATC TTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACC

CTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCT

C T C A AG A AT GGT C GG A AT GAT C AGT GG A AC T AC C AC AG A A AGGG A AC TGT GG

GAT GACTGGGC ACC AT AT GAAGACGT GGAAATTGGACCC AAT GGAGTTCTGA

GGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTG

GACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACAT

TCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATA

CTGGGCT ATCC AAAAATCC AATCGAGCTTGT AGAAGGTT GGTTC AGT AGTT G

GAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATT

CTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGA

AAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACTCAA

ATCCTGCTAGGTATGAAAAAAACTAACaGATATCACGCTCGAGCGTACGCCA

CCATGTTCGTGTTTCTGGTGCTGCTGCCTCTGGTGAGCTCCCAGTGCGTGAAC

CTGACCACAAGGACCCAGCTGCCCCCTGCCTATACCAATTCCTTCACACGGGG

CGTGTACTATCCCGACAAGGTGTTCCGGAGCAGCGTGCTGCACTCCACACAG

GATCTGTTTCTGCCTTTCTTTTCTAACGTGACCTGGTTCCACGCCATCCACGTG

AGCGGCACCAATGGCACAAAGCGGTTCGACAATCCAGTGCTGCCCTTTAACG

ATGGCGTGTACTTCGCCTCCACCGAGAAGTCTAACATCATCAGAGGCTGGAT

CTTTGGCACCACACTGGACAGCAAGACACAGTCCCTGCTGATCGTGAACAAT

GCCACCAACGTGGTCATCAAGGTGTGCGAGTTCCAGTTTTGTAATGATCCATT

CC T GGGC GT GT AC T AT C AC A AG A AC A AT A AGT C TT GGAT GGAGAGC GAGTTT

CGCGTGTATTCCTCTGCCAACAATTGCACATTTGAGTACGTGTCCCAGCCCTT

CCTGAT GGACCTGGAGGGC AAGC AGGGC AATTT C AAGA ACCTGAGGGAGTT C

GTGTTTAAGAATATCGATGGCTACTTCAAAATCTACTCCAAGCACACCCCAAT

CAACCTGGTGCGCGACCTGCCACAGGGCTTCTCTGCCCTGGAGCCACTGGTG

GATCTGCCCATCGGCATCAACATCACCCGGTTTCAGACACTGCTGGCCCTGCA

CAGAAGCTACCTGACACCAGGCGACAGCTCCTCTGGATGGACCGCAGGAGCA

GCAGCCTACTATGTGGGCTATCTGCAGCCCAGGACCTTCCTGCTGAAGTACAA

CGAGAATGGCACCATCACAGACGCCGTGGATTGCGCCCTGGATCCCCTGTCT

GAGACCAAGTGTACACTGAAGAGCTTTACCGTGGAGAAGGGCATCTATCAGA

CAAGCAATTTCAGGGTGCAGCCTACCGAGTCCATCGTGCGCTTTCCCAATATC

ACAAACCTGTGCCCTTTTGGCGAGGTGTTCAACGCAACCCGCTTCGCCAGCGT

GTACGCCTGGAATAGGAAGCGCATCTCCAACTGCGTGGCCGACTATTCTGTG

CTGTACAACAGCGCCTCCTTCTCTACCTTTAAGTGCTATGGCGTGAGCCCCAC AAAGCTGAATGACCTGTGCTTTACCAACGTGTACGCCGATTCCTTCGTGATCA

GGGGCGACGAGGTGCGCCAGATCGCACCAGGACAGACAGGCAAGATCGCAG

ACTACAATTATAAGCTGCCTGACGATTTCACCGGCTGCGTGATCGCCTGGAAC

TC T A AC A AT C T GG AT AGC A A AGT GGGC GGC A AC T AC A AT T AT C T GT AC C GGC

TGTTTAGAAAGTCTAATCTGAAGCCATTCGAGAGGGACATCTCCACAGAAAT

CTACCAGGCCGGCTCTACCCCCTGCAATGGCGTGGAGGGCTTTAACTGTTATT

TCCCTCTGCAGAGCTACGGCTTCCAGCCAACAAACGGCGTGGGCTATCAGCC

CTACCGCGTGGTGGTGCTGTCTTTTGAGCTGCTGCACGCACCTGCAACAGTGT

GCGGACC A AAGAAGAGC ACC AATCTGGT GAAGAAC AAGT GCGT GAACTTC A

ACTTC AACGGACTGACCGGAAC AGGCGT GCTGACCGAGTCC A AC AAGAAGTT

CCTGCCTTTTCAGCAGTTCGGCAGGGACATCGCAGATACCACAGACGCCGTG

CGCGACCCTCAGACCCTGGAGATCCTGGACATCACACCATGCTCCTTCGGCG

GCGTGTCTGTGATCACACCAGGCACCAATACAAGCAACCAGGTGGCCGTGCT

GT ATC AGGACGT GAATTGT ACCGAGGT GCC AGT GGC AATCC ACGC AGAT C AG

CTGACCCCTACATGGCGGGTGTACTCTACCGGCAGCAACGTGTTCCAGACAA

GAGCCGGATGCCTGATCGGAGCAGAGCACGTGAACAATAGCTATGAGTGCGA

CATCCCTATCGGCGCCGGCATCTGTGCCTCCTACCAGACCCAGACAAACTCCC

CAAGGTCTGTGGGAGATGAGGCCGAAGACTTTGTGGAAGTCCACCTGCCTGA

T GT GC AT A AC C AGGT GT C T GGCGT C GAC CTGGG ACTGCC A A ATT GGGGC A AG

TACGTGCTGCTGAGTGCTGGAGCACTGACTGCCCTGATGCTGATCATTTTCCT

GATGACCTGCTGTCGGCGCGTGAACAGAAGTGAGCCCACTCAGCACAATCTG

CGAGGAACCGGGAGAGAAGTGTCAGTCACACCTCAGAGCGGGAAAATCATT

AGT AGTT GGGAAT C AC AT AAAAGCGGGGGCGAGACC AGGCTGTGAGCT AGC

CAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGC

CTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAACTAACAGCAATCATG

GAAGTCCACGATTTTGAGACCGACGAGTTCAATGATTTCAATGAAGATGACT

ATGCCACAAGAGAATTCCTGAATCCCGATGAGCGCATGACGTACTTGAATCA

TGCTGATTACAATTTGAATTCTCCTCTAATTAGTGATGATATTGACAATTTGAT

CAGGAAATTCAATTCTCTTCCGATTCCCTCGATGTGGGATAGTAAGAACTGGG

ATGGAGTTCTTGAGATGTTAACATCATGTCAAGCCAATCCCATCTCAACATCT

C AGAT GC AT AAAT GGATGGGA AGTT GGTT AAT GTCTGAT AATC ATGAT GCC A

GT C AAGGGT AT AGTTTTTT AC ATGA AGTGGAC AAAGAGGC AGAAAT AAC ATT

TGACGTGGTGGAGACCTTCATCCGCGGCTGGGGCAACAAACCAATTGAATAC

AT C AAAAAGGA AAGATGGACTGACTC ATTC AAAATTCTCGCTT ATTTGTGT C A AAAGTTTTTGGACTTACACAAGTTGACATTAATCTTAAATGCTGTCTCTGAGG

TGGAATTGCTCAACTTGGCGAGGACTTTCAAAGGCAAAGTCAGAAGAAGTTC

TCATGGAACGAACATATGCAGGATTAGGGTTCCCAGCTTGGGTCCTACTTTTA

TTTCAGAAGGATGGGCTTACTTCAAGAAACTTGATATTCTAATGGACCGAAA

CTTTCTGTT AAT GGTC AAAGAT GTGATT AT AGGGAGGAT GC AA ACGGT GCT AT

CCATGGTATGTAGAATAGACAACCTGTTCTCAGAGCAAGACATCTTCTCCCTT

CT AAAT ATCT AC AGAATT GGAGAT AAAATTGT GGAGAGGC AGGGAAATTTTT

CTTATGACTTGATTAAAATGGTGGAACCGATATGCAACTTGAAGCTGATGAA

ATTAGCAAGAGAATCAAGGCCTTTAGTCCCACAATTCCCTCATTTTGAAAATC

ATATCAAGACTTCTGTTGATGAAGGGGCAAAAATTGACCGAGGTATAAGATT

CC TC CAT GATC AGAT AAT GAGT GT GA A A AC AGT GGAT C T C AC AC T GGT GATTT

AT GGAT C GTT C AG AC ATT GGGGT C ATCC TTTT AT AG ATT ATT AC AC T GGACT A

GAAAAATTACATTCCCAAGTAACCATGAAGAAAGATATTGATGTGTCATATG

CAAAAGCACTTGCAAGTGATTTAGCTCGGATTGTTCTATTTCAACAGTTCAAT

GATCATAAAAAGTGGTTCGTGAATGGAGACTTGCTCCCTCATGATCATCCCTT

T A A A AGT CAT GTT A A AGA A A AT AC AT GGCC C AC AGCTGC TC A AGTT C A AGAT

TTTGGAGATAAATGGCATGAACTTCCGCTGATTAAATGTTTTGAAATACCCGA

CTTACTAGACCCATCGATAATATACTCTGACAAAAGTCATTCAATGAATAGGT

CAGAGGTGTTGAAACATGTCCGAATGAATCCGAACACTCCTATCCCTAGTAA

AAAGGTGTTGCAGACTATGTTGGACACAAAGGCTACCAATTGGAAAGAATTT

CTT AAAGAGATT GAT GAG AAGGGCTT AGAT GATGATGATCT AATT ATTGGTCT

TAAAGGAAAGGAGAGGGAACTGAAGTTGGCAGGTAGATTTTTCTCCCTAATG

TCTTGGAAATTGCGAGAATACTTTGTAATTACCGAATATTTGATAAAGACTCA

TTTCGTCCCTATGTTTAAAGGCCTGACAATGGCGGACGATCTAACTGCAGTCA

TTAAAAAGATGTTAGATTCCTCATCCGGCCAAGGATTGAAGTCATATGAGGC

AATTTGCATAGCCAATCACATTGATTACGAAAAATGGAATAACCACCAAAGG

AAGTTATCAAACGGCCCAGTGTTCCGAGTTATGGGCCAGTTCTTAGGTTATCC

ATCCTTAATCGAGAGAACTCATGAATTTTTTGAGAAAAGTCTTATATACTACA

ATGGAAGACCAGACTTGATGCGTGTTCACAACAACACACTGATCAATTCAAC

CTCCCAACGAGTTTGTTGGCAAGGACAAGAGGGTGGACTGGAAGGTCTACGG

CAAAAAGGATGGACTATCCTCAATCTACTGGTTATTCAAAGAGAGGCTAAAA

T C AGA A AC AC T GCTGT C A A AGT CTT GGC AC A AGGT GAT AAT C A AGTT ATTT GC

AC AC AGT AT A A A ACGA AG A A AT C GAGA A AC GTT GT AGAATT AC AGGGT GC T C

T C A AT C A A AT GGTTTCT A AT AAT GAGA A A ATT AT GAC T GCA AT C A A A AT AGG GAC AGGGAAGTT AGGACTTTT GAT AAAT GACGAT GAGACT AT GC AATCTGC A

GATTACTTGAATTATGGAAAAATACCGATTTTCCGTGGAGTGATTAGAGGGTT

AG AG AC C A AG AG AT GGT C AC GAGT GACTTGT GT C AC C A AT GACC A A AT AC CC

ACTTGTGCTAATATAATGAGCTCAGTTTCCACAAATGCTCTCACCGTAGCTCA

TTTTGCTGAGAACCC AAT C AAT GCC ATGAT AC AGT AC A ATT ATTTT GGGAC AT

TTGCTAGACTCTTGTTGATGATGCATGATCCTGCTCTTCGTCAATCATTGTATG

AAGTTCAAGATAAGATACCGGGCTTGCACAGTTCTACTTTCAAATACGCCATG

TTGTATTTGGACCCTTCCATTGGAGGAGTGTCGGGCATGTCTTTGTCCAGGTTT

TTGATTAGAGCCTTCCCAGATCCCGTAACAGAAAGTCTCTCATTCTGGAGATT

CATCCATGTACATGCTCGAAGTGAGCATCTGAAGGAGATGAGTGCAGTATTT

GGAAACCCCGAGATAGCCAAGTTTCGAATAACTCACATAGACAAGCTAGTAG

AAGATCCAACCTCTCTGAACATCGCTATGGGAATGAGTCCAGCGAACTTGTT

AAAGACTGAGGTTAAAAAATGCTTAATCGAATCAAGACAAACCATCAGGAAC

CAGGTGATTAAGGATGCAACCATATATTTGTATCATGAAGAGGATCGGCTCA

GAAGTTTCTTATGGTCAATAAATCCTCTGTTCCCTAGATTTTTAAGTGAATTCA

AATCAGGCACTTTTTTGGGAGTCGCAGACGGGCTCATCAGTCTATTTCAAAAT

TCTCGTACTATTCGGAACTCCTTTAAGAAAAAGTATCATAGGGAATTGGATGA

TTTGATTGTGAGGAGTGAGGTATCCTCTTTGACACATTTAGGGAAACTTCATT

T GAGA AGGGGAT CAT GT A A A AT GT GGAC AT GTT C AGC T ACTC AT GCTGAC AC

ATTAAGATACAAATCCTGGGGCCGTACAGTTATTGGGACAACTGTACCCCAT

CCATTAGAAATGTTGGGTCCACAACATCGAAAAGAGACTCCTTGTGCACCAT

GTAACACATCAGGGTTCAATTATGTTTCTGTGCATTGTCCAGACGGGATCCAT

GACGTCTTTAGTTCACGGGGACCATTGCCTGCTTATCTAGGGTCTAAAACATC

TGAATCTACATCTATTTTGCAGCCTTGGGAAAGGGAAAGCAAAGTCCCACTG

ATTAAAAGAGCTACACGTCTTAGAGATGCTATCTCTTGGTTTGTTGAACCCGA

CTCTAAACTAGCAATGACTATACTTTCTAACATCCACTCTTTAACAGGCGAAG

AATGGACCAAAAGGCAGCATGGGTTCAAAAGAACAGGGTCTGCCCTTCATAG

GTTTTCGACATCTCGGATGAGCCATGGTGGGTTCGCATCTCAGAGCACTGCAG

C ATTGACC AGGTT GATGGC AACT AC AGAC ACC ATGAGGGATCTGGGAGAT C A

GAATTTCGACTTTTTATTCCAAGCAACGTTGCTCTATGCTCAAATTACCACCA

CTGTTGCAAGAGACGGATGGATCACCAGTTGTACAGATCATTATCATATTGCC

TGTAAGTCCTGTTTGAGACCCATAGAAGAGATCACCCTGGACTCAAGTATGG

ACTACACGCCCCCAGATGTATCCCATGTGCTGAAGACATGGAGGAATGGGGA

AGGTTCGTGGGGAC AAGAGAT AAAAC AGATCT ATCCTTT AGAAGGGAATTGG AAGAATTTAGCACCTGCTGAGCAATCCTATCAAGTCGGCAGATGTATAGGTTT

TCTATATGGAGACTTGGCGTATAGAAAATCTACTCATGCCGAGGACAGTTCTC

TATTTCCTCTATCTATACAAGGTCGTATTAGAGGTCGAGGTTTCTTAAAAGGG

TTGCT AGACGGATT AAT GAGAGC A AGTT GCTGCC AAGT AAT AC ACCGGAGAA

GTCTGGCTCATTTGAAGAGGCCGGCCAACGCAGTGTACGGAGGTTTGATTTA

CTTGATTGATAAATTGAGTGTATCACCTCCATTCCTTTCTCTTACTAGATCAGG

ACCTATTAGAGACGAATTAGAAACGATTCCCCACAAGATCCCAACCTCCTAT

CCGACAAGCAACCGTGATATGGGGGTGATTGTCAGAAATTACTTCAAATACC

AATGCCGTCTAATTGAAAAGGGAAAATACAGATCACATTATTCACAATTATG

GTTATTCTCAGATGTCTTATCCATAGACTTCATTGGACCATTCTCTATTTCCAC

CACCCTCTTGCAAATCCTATACAAGCCATTTTTATCTGGGAAAGATAAGAATG

AGTTGAGAGAGCTGGCAAATCTTTCTTCATTGCTAAGATCAGGAGAGGGGTG

GGA AGAC AT AC AT GT GA A ATTC TT C AC C A AGGAC AT ATT ATT GT GT C C AGAG

GAAAT C AG AC AT GCTTGC AAGTTCGGGATTGCT AAGGAT AAT A AT AAAGAC A

TGAGCTATCCCCCTTGGGGAAGGGAATCCAGAGGGACAATTACAACAATCCC

TGTTTATTATACGACCACCCCTTACCCAAAGATGCTAGAGATGCCTCCAAGAA

TCCAAAATCCCCTGCTGTCCGGAATCAGGTTGGGCCAATTACCAACTGGCGCT

CATTATAAAATTCGGAGTATATTACATGGAATGGGAATCCATTACAGGGACTT

CTTGAGTTGTGGAGACGGCTCCGGAGGGATGACTGCTGCATTACTACGAGAA

AATGTGCATAGCAGAGGAATATTCAATAGTCTGTTAGAATTATCAGGGTCAG

TCATGCGAGGCGCCTCTCCTGAGCCCCCCAGTGCCCTAGAAACTTTAGGAGG

AG AT A A AT C GAG AT GT GT A A AT GGT G A A AC AT GT T GGG A AT ATCCATCT G AC

TTATGTGACCCAAGGACTTGGGACTATTTCCTCCGACTCAAAGCAGGCTTGGG

GCTTCAAATTGATTTAATTGTAATGGATATGGAAGTTCGGGATTCTTCTACTA

GCCTGAAAATTGAGACGAATGTTAGAAATTATGTGCACCGGATTTTGGATGA

GC A AGGAGTTTT AATCT AC AAGACTT AT GGAAC AT AT ATTTGT GAGAGC GAA

A AG A AT GC AGT A AC A AT C CTT GGTCC C AT GTT C A AGAC GGTCGAC TT AGTT C A

AACAGAATTTAGTAGTTCTCAAACGTCTGAAGTATATATGGTATGTAAAGGTT

TGAAGAAATTAATCGATGAACCCAATCCCGATTGGTCTTCCATCAATGAATCC

TGGAAAAACCTGTACGCATTCCAGTCATCAGAACAGGAATTTGCCAGAGCAA

AGAAGGTTAGTACATACTTTACCTTGACAGGTATTCCCTCCCAATTCATTCCT

GATCCTTTTGTAAACATTGAGACTATGCTACAAATATTCGGAGTACCCACGGG

TGTGTCTCATGCGGCTGCCTTAAAATCATCTGATAGACCTGCAGATTTATTGA

CCATTAGCCTTTTTTATATGGCGATTATATCGTATTATAACATCAATCATATCA GAGTAGGACCGATACCTCCGAACCCCCCATCAGATGGAATTGCACAAAATGT

GGGGATCGCTATAACTGGTATAAGCTTTTGGCTGAGTTTGATGGAGAAAGAC

ATTCCACTATATCAACAGTGTTTAGCAGTTATCCAGCAATCATTCCCGATTAG

GT GGGAGGCTGTTTC AGT AAAAGGAGGAT AC AAGC AGAAGT GGAGT ACT AG

AGGTGATGGGCTCCCAAAAGATACCCGAACTTCAGACTCCTTGGCCCCAATC

GGGAACTGGATCAGATCTCTGGAATTGGTCCGAAACCAAGTTCGTCTAAATC

CATTCAATGAGATCTTGTTCAATCAGCTATGTCGTACAGTGGATAATCATTTG

AAAT GGT C AAATTT GCGAAGAAAC AC AGGAAT GATT GAAT GGATC AAT AGAC

GAATTTCAAAAGAAGACCGGTCTATACTGATGTTGAAGAGTGACCTACACGA

GGA A A AC TC TT GGAGAGATT A A A A A AT CAT GAGGAGACTCC A A AC TTT A AGT

ATGAAAAAAACTTTGATCCTTAAGACCCTCTTGTGGTTTTTATTTTTTATCTGG

TTTTGTGGTCTTCGT.

In other embodiments, the nucleic acid comprises the sequence of SEQ ID NO:

21, shown below (VSV vector: Convac V2 South Africa):

ACGAAGAC AAAC AAACC ATT ATT AT C ATT AAAAGGCTC AGGAGAAACTTT AA

C AGT AAT C AAA ATGTCTGTT AC AGTC AAGAGAAT C ATTGAC AAC AC AGTC AT

AGTTCCAAAACTTCCTGCAAATGAGGATCCAGTGGAATACCCGGCAGATTAC

TTCAGAAAATCAAAGGAGATTCCTCTTTACATCAATACTACAAAAAGTTTGTC

AGATCTAAGAGGATATGTCTACCAAGGCCTCAAATCCGGAAATGTATCAATC

AT AC AT GT C A AC AGC T AC TT GT AT GG AGC ATT A A AGG AC ATC C GGGGT A AGT

TGGATAAAGATTGGTCAAGTTTCGGAATAAACATCGGGAAAGCAGGGGATAC

AATCGGAATATTTGACCTTGTATCCTTGAAAGCCCTGGACGGCGTACTTCCAG

AT GGAGT ATCGG AT GCTTCC AGAACC AGCGC AGAT GAC AAAT GGTT GCCTTT

GTATCTACTTGGCTTATACAGAGTGGGCAGAACACAAATGCCTGAATACAGA

A A A A AGC TC AT GGAT GGGC T GAC A A AT C A AT GCA A A AT GAT C A AT GA AC AGT

TTGAACCTCTTGTGCCAGAAGGTCGTGACATTTTTGATGTGTGGGGAAATGAC

AGTAATTACACAAAAATTGTCGCTGCAGTGGACATGTTCTTCCACATGTTCAA

AAAACATGAATGTGCCTCGTTCAGATACGGAACTATTGTTTCCAGATTCAAAG

ATTGTGCTGCATTGGCAACATTTGGACACCTCTGCAAAATAACCGGAATGTCT

ACAGAAGATGTAACGACCTGGATCTTGAACCGAGAAGTTGCAGATGAAATGG

TCCAAATGATGCTTCCAGGCCAAGAAATTGACAAGGCCGATTCATACATGCC

TTATTTGATCGACTTTGGATTGTCTTCTAAGTCTCCATATTCTTCCGTCAAAAA

CCCTGCCTTCCACTTCTGGGGGCAATTGACAGCTCTTCTGCTCAGATCCACCA

GAGCAAGGAATGCCCGACAGCCTGATGACATTGAGTATACATCTCTTACTAC AGCAGGTTTGTTGTACGCTTATGCAGTAGGATCCTCTGCCGACTTGGCACAAC

AGTTTTGTGTTGGAGATAACAAATACACTCCAGATGATAGTACCGGAGGATT

GACGACTAATGCACCGCCACAAGGCAGAGATGTGGTCGAATGGCTCGGATGG

T TT G A AG AT C A A A AC AG A A A AC C G AC TC C T GAT AT GAT GC AGT AT GC G A A A A

GAGCAGTCATGTCACTGCAAGGCCTAAGAGAGAAGACAATTGGCAAGTATGC

TAAGTCAGAATTTGACAAATGACCCTATAATTCTCAGATCACCTATTATATAT

TATGCTACATATGAAAAAAACTAACAGATATCATGGATAATCTCACAAAAGT

TCGTGAGTATCTCAAGTCCTATTCTCGTCTGGATCAGGCGGTAGGAGAGATAG

ATGAGATCGAAGCACAACGAGCTGAAAAGTCCAATTATGAGTTGTTCCAAGA

GGATGGAGTGGAAGAGCATACTAAGCCCTCTTATTTTCAGGCAGCAGATGAT

TCTGAC AC AGA AT C T GA AC C AG A A ATT GA AG AC A AT C A AGGTTT GT AT GC AC

CAGATCCAGAAGCTGAGCAAGTTGAAGGCTTTATACAGGGGCCTTTAGATGA

CT AT GC AGAT GAGGAAGT GGAT GTT GT ATTT ACTTCGGACTGGAAAC AGCCT

GAGCTTGAATCTGACGAGCATGGAAAGACCTTACGGTTGACATCGCCAGAGG

GTTTAAGTGGAGAGCAGAAATCCCAGTGGCTTTCGACGATTAAAGCAGTCGT

GC AAAGTGCC AAAT ACTGGAATCTGGC AGAGT GC AC ATTTGAAGC ATCGGGA

G A AGGGGT C AT T AT G A AGG AGC GC C AG AT A AC T C C GGAT GT AT AT A AGGT C A

CTCCAGTGATGAACACACATCCGTCCCAATCAGAAGCAGTATCAGATGTTTG

GTCTCTCTCAAAGACATCCATGACTTTCCAACCCAAGAAAGCAAGTCTTCAGC

CTCTCACCATATCCTTGGATGAATTGTTCTCATCTAGAGGAGAGTTCATCTCT

GTCGGAGGTGACGGACGAATGTCTCATAAAGAGGCCATCCTGCTCGGCCTGA

GATACAAAAAGTTGTACAATCAGGCGAGAGTCAAATATTCTCTGTAGACTAT

GAAAAAAAGTAACAGATATCACGATCTAAGTGTTATCCCAATCCATTCATCA

T G AGTT C C TT A A AG A AG AT TC TC GGT C T G A AGGGG A A AGGT A AG A A AT C T A A

GAAATTAGGGATCGCACCACCCCCTTATGAAGAGGACACTAGCATGGAGTAT

GCTCCGAGCGCTCCAATTGACAAATCCTATTTTGGAGTTGACGAGATGGACA

CCTATGATCCGAATCAATTAAGATATGAGAAATTCTTCTTTACAGTGAAAATG

ACGGTTAGATCTAATCGTCCGTTCAGAACATACTCAGATGTGGCAGCCGCTGT

ATCCCATTGGGATCACATGTACATCGGAATGGCAGGGAAACGTCCCTTCTAC

AAAATCTTGGCTTTTTTGGGTTCTTCTAATCTAAAGGCCACTCCAGCGGTATT

GGCAGATCAAGGTCAACCAGAGTATCACACTCACTGCGAAGGCAGGGCTTAT

TTGCCACATAGGATGGGGAAGACCCCTCCCATGCTCAATGTACCAGAGCACT

T C AGAAGACC ATTC AAT AT AGGTCTTT AC AAGGGAACGATTGAGCTC AC A AT

GACCATCTACGATGATGAGTCACTGGAAGCAGCTCCTATGATCTGGGATCATT TCAATTCTTCCAAATTTTCTGATTTCAGAGAGAAGGCCTTAATGTTTGGCCTG

ATTGTCGAGAAAAAGGCATCTGGAGCGTGGGTCCTGGATTCTATCAGCCACT

TCAAATGAGCTAGTCTAACTTCTAGCTTCTGAACAATCCCCGGTTTACTCAGT

CTCTCCTAATTCCAGCCTCTCGAACAACTAATATCCTGTCTTTTCTATCCCTAT

GAAAAAAACTAACAGAGATCGATCTGTTTACGCGTCACTATGAAGTGCCTTTT

GTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCC

ACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGC

CCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCATAC

A AGT C A A A AT GCC C A AGAGTC AC A AGGC T ATT C A AGC AGACGGTT GGAT GT G

TCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGT

ATATAACACAGTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGA

AAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCT

C AAAGTT GTGGAT AT GC AACTGT GACGGAT GCCGAAGC AGT GATTGTCC AGG

TGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCA

CAGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTC

TACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCA

TTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGA

AAGGAGGGC AC AGGGTT C AGAAGT AACT ACTTTGCTT AT GAAACTGGAGGC A

AGGCCTGC AAAAT GC AAT ACTGC AAGC ATT GGGGAGTC AGACTCCC ATC AGG

TGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTG

AATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTA

AGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAAC

CTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATC

TTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACC

CTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCT

C T C A AG A AT GGT C GG A AT GAT C AGT GG A AC T AC C AC AG A A AGGG A AC TGT GG

GAT GACTGGGC ACC AT AT GAAGACGT GGAAATTGGACCC AAT GGAGTTCTGA

GGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTG

GACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACAT

TCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATA

CTGGGCT ATCC AAAAATCC AATCGAGCTTGT AGAAGGTT GGTTC AGT AGTT G

GAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATT

CTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGA

AAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACTCAA ATCCTGCTAGGTATGAAAAAAACTAACaGATATCACGCTCGAGCGTACGCCA

CCATGTTCGTGTTTCTGGTGCTGCTGCCTCTGGTGAGCTCCCAGTGCGTGAAC

TTCACCACAAGGACCCAGCTGCCCCCTGCCTATACCAATTCCTTCACACGGGG

CGTGTACTATCCCGACAAGGTGTTCCGGAGCAGCGTGCTGCACTCCACACAG

GATCTGTTTCTGCCTTTCTTTTCTAACGTGACCTGGTTCCACGCCATCCACGTG

AGCGGCACCAATGGCACAAAGCGGTTCGCCAATCCAGTGCTGCCCTTTAACG

ATGGCGTGTACTTCGCCTCCACCGAGAAGTCTAACATCATCAGAGGCTGGAT

CTTTGGCACCACACTGGACAGCAAGACACAGTCCCTGCTGATCGTGAACAAT

GCCACCAACGTGGTCATCAAGGTGTGCGAGTTCCAGTTTTGTAATGATCCATT

CC T GGGC GT GT AC T AT C AC A AG A AC A AT A AGT C TT GGAT GGAGAGC GAGTTT

CGCGTGTATTCCTCTGCCAACAATTGCACATTTGAGTACGTGTCCCAGCCCTT

CCTGAT GGACCTGGAGGGC AAGC AGGGC AATTT C AAGA ACCTGAGGGAGTT C

GTGTTTAAGAATATCGATGGCTACTTCAAAATCTACTCCAAGCACACCCCAAT

CAACCTGGTGCGCGGCCTGCCACAGGGCTTCTCTGCCCTGGAGCCACTGGTG

GATCTGCCCATCGGCATCAACATCACCCGGTTTCAGACACTGCTGGCCCTGCA

CAGAAGCTACCTGACACCAGGCGACAGCTCCTCTGGATGGACCGCAGGAGCA

GCAGCCTACTATGTGGGCTATCTGCAGCCCAGGACCTTCCTGCTGAAGTACAA

CGAGAATGGCACCATCACAGACGCCGTGGATTGCGCCCTGGATCCCCTGTCT

GAGACCAAGTGTACACTGAAGAGCTTTACCGTGGAGAAGGGCATCTATCAGA

CAAGCAATTTCAGGGTGCAGCCTACCGAGTCCATCGTGCGCTTTCCCAATATC

ACAAACCTGTGCCCTTTTGGCGAGGTGTTCAACGCAACCCGCTTCGCCAGCGT

GTACGCCTGGAATAGGAAGCGCATCTCCAACTGCGTGGCCGACTATTCTGTG

CTGTACAACAGCGCCTCCTTCTCTACCTTTAAGTGCTATGGCGTGAGCCCCAC

AAAGCTGAATGACCTGTGCTTTACCAACGTGTACGCCGATTCCTTCGTGATCA

GGGGCGACGAGGTGCGCCAGATCGCACCAGGACAGACAGGCAATATCGCAG

ACTACAATTATAAGCTGCCTGACGATTTCACCGGCTGCGTGATCGCCTGGAAC

TC T A AC A AT C T GGAT AGC A A AGT GGGC GGC A AC T AC A AT T AT C T GT AC C GGC

TGTTTAGAAAGTCTAATCTGAAGCCATTCGAGAGGGACATCTCCACAGAAAT

CTACCAGGCCGGCTCTACCCCCTGCAATGGCGTGAAGGGCTTTAACTGTTATT

TCCCTCTGCAGAGCTACGGCTTCCAGCCAACATATGGCGTGGGCTATCAGCCC

TACCGCGTGGTGGTGCTGTCTTTTGAGCTGCTGCACGCACCTGCAACAGTGTG

CGGACC A A AGA AGAGC AC C A ATCTGGT GA AG A AC A AGT GC GT GA ACTT C A A

CTTCAACGGACTGACCGGAACAGGCGTGCTGACCGAGTCCAACAAGAAGTTC

CTGCCTTTTCAGCAGTTCGGCAGGGACATCGCAGATACCACAGACGCCGTGC GCGACCCTCAGACCCTGGAGATCCTGGACATCACACCATGCTCCTTCGGCGG

CGTGTCTGTGATCACACCAGGCACCAATACAAGCAACCAGGTGGCCGTGCTG

TATCAGGGCGTGAATTGTACCGAGGTGCCAGTGGCAATCCACGCAGATCAGC

TGACCCCTACATGGCGGGTGTACTCTACCGGCAGCAACGTGTTCCAGACAAG

AGCCGGATGCCTGATCGGAGCAGAGCACGTGAACAATAGCTATGAGTGCGAC

ATCCCTATCGGCGCCGGCATCTGTGCCTCCTACCAGACCCAGACAAACTCCCC

AGAATCAAGCGTGATTCCTCTGGTCCATCCACTGGCAGATCCCTCCACAGTGT

TCAAAGACGGAGATGAGGCCGAAGACTTTGTGGAAGTCCACCTGCCTGATGT

GCATAACCAGGTGTCTGGCGTCGACCTGGGACTGCCAAATTGGGGCAAGTAC

GTGCTGCTGAGTGCTGGAGCACTGACTGCCCTGATGCTGATCATTTTCCTGAT

GACCTGCTGTCGGCGCGTGAACAGAAGTGAGCCCACTCAGCACAATCTGCGA

GGAACCGGGAGAGAAGTGTCAGTCACACCTCAGAGCGGGAAAATCATTAGT

AGTTGGGAATCACATAAAAGCGGGGGCGAGACCAGGCTGTGAGCTAGCCAG

ATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTC

AATT AT ATTT GAGTTTTT AATTTTT ATGA AAAAAACT AAC AGC AAT CAT GGAA

GTCCACGATTTTGAGACCGACGAGTTCAATGATTTCAATGAAGATGACTATGC

CACAAGAGAATTCCTGAATCCCGATGAGCGCATGACGTACTTGAATCATGCT

GATTACAATTTGAATTCTCCTCTAATTAGTGATGATATTGACAATTTGATCAG

GAAATTCAATTCTCTTCCGATTCCCTCGATGTGGGATAGTAAGAACTGGGATG

GAGTTCTTGAGATGTTAACATCATGTCAAGCCAATCCCATCTCAACATCTCAG

AT GC AT A A AT GGAT GGGA AGTTGGTT AAT GT C T GAT AAT CAT GAT GCC AGT C

AAGGGT AT AGTTTTTT AC ATGA AGTGGAC AAAGAGGC AGAAAT AAC ATTT GA

CGT GGTGGAGACCTT CATCCGCGGCTGGGGC AAC AA ACC AATT GAAT AC AT C

AAAAAGGAAAGATGGACTGACTCATTCAAAATTCTCGCTTATTTGTGTCAAA

AGTTTTTGGACTTACACAAGTTGACATTAATCTTAAATGCTGTCTCTGAGGTG

GAATTGCTCAACTTGGCGAGGACTTTCAAAGGCAAAGTCAGAAGAAGTTCTC

ATGGAACGAACATATGCAGGATTAGGGTTCCCAGCTTGGGTCCTACTTTTATT

TCAGAAGGATGGGCTTACTTCAAGAAACTTGATATTCTAATGGACCGAAACT

TTCTGTTAATGGTCAAAGATGTGATTATAGGGAGGATGCAAACGGTGCTATCC

ATGGTATGTAGAATAGACAACCTGTTCTCAGAGCAAGACATCTTCTCCCTTCT

AAAT ATCT AC AGAATTGGAGAT AAAATTGTGGAGAGGC AGGGAAATTTTTCT

T AT GAC TT GATT A A A AT GGT GGA ACC GAT AT GCA AC TT GA AGC T GAT GA A AT

TAGCAAGAGAATCAAGGCCTTTAGTCCCACAATTCCCTCATTTTGAAAATCAT

ATCAAGACTTCTGTTGATGAAGGGGCAAAAATTGACCGAGGTATAAGATTCC TCCATGATCAGATAATGAGTGTGAAAACAGTGGATCTCACACTGGTGATTTAT

GGATCGTTCAGACATTGGGGTCATCCTTTTATAGATTATTACACTGGACTAGA

A A A ATT AC ATTCC C A AGT A AC CAT GA AG A A AG AT ATT GAT GT GT CAT AT GCA

AAAGCACTTGCAAGTGATTTAGCTCGGATTGTTCTATTTCAACAGTTCAATGA

TCATAAAAAGTGGTTCGTGAATGGAGACTTGCTCCCTCATGATCATCCCTTTA

AAAGT C ATGTT AAAGAAAAT AC AT GGCCC AC AGCTGCTC AAGTTC AAGATTT

TGGAGATAAATGGCATGAACTTCCGCTGATTAAATGTTTTGAAATACCCGACT

TACTAGACCCATCGATAATATACTCTGACAAAAGTCATTCAATGAATAGGTC

AGAGGTGTTGAAACATGTCCGAATGAATCCGAACACTCCTATCCCTAGTAAA

AAGGT GTT GC AG ACT AT GTTGGAC AC AAAGGCT ACC AATTGGAAAGAATTTC

TTAAAGAGATTGATGAGAAGGGCTTAGATGATGATGATCTAATTATTGGTCTT

AAAGGAAAGGAGAGGGAACTGAAGTTGGCAGGTAGATTTTTCTCCCTAATGT

CTTGGAAATTGCGAGAATACTTTGTAATTACCGAATATTTGATAAAGACTCAT

TTCGTCCCTATGTTTAAAGGCCTGACAATGGCGGACGATCTAACTGCAGTCAT

T A A A A AG AT GTT AGATTC CTC AT C CGGC C A AGGATT GA AGT CAT AT G AGGC A

ATTT GC AT AGCC A ATC AC ATTGATT ACGAAAAAT GGAAT AACC ACC AAAGGA

AGTTATCAAACGGCCCAGTGTTCCGAGTTATGGGCCAGTTCTTAGGTTATCCA

TCCTTAATCGAGAGAACTCATGAATTTTTTGAGAAAAGTCTTATATACTACAA

TGGAAGACCAGACTTGATGCGTGTTCACAACAACACACTGATCAATTCAACC

TCCC AACGAGTTTGTTGGC AAGGAC A AGAGGGT GGACTGGAAGGTCT ACGGC

AAAAAGGAT GGACT ATCCTC AATCT ACTGGTT ATT C AAAGAGAGGCT AAAAT

C AGA AAC ACTGCTGT CAAAGTCTTGGC AC AAGGT GAT AATC AAGTT ATTTGC

AC AC AGT AT A A A ACGA AG A A AT C GAGA A AC GTT GT AG A ATT AC AGGGT GC T C

T C A AT C A A AT GGTTTCT A AT A AT GAGA A A ATT AT GAC T GCA AT C A A A AT AGG

GACAGGG AAGTT AGGACTTTT GAT AAAT GACGAT GAGACT AT GC AATCTGC A

GATTACTTGAATTATGGAAAAATACCGATTTTCCGTGGAGTGATTAGAGGGTT

AG AG AC C A AG AG AT GGT C AC GAGT GACTTGT GT C AC C A AT GACC A A AT AC CC

ACTTGTGCTAATATAATGAGCTCAGTTTCCACAAATGCTCTCACCGTAGCTCA

TTTTGCTGAGAACCC AAT C AAT GCC ATGAT AC AGT AC A ATT ATTTT GGGAC AT

TTGCTAGACTCTTGTTGATGATGCATGATCCTGCTCTTCGTCAATCATTGTATG

AAGTTCAAGATAAGATACCGGGCTTGCACAGTTCTACTTTCAAATACGCCATG

TTGTATTTGGACCCTTCCATTGGAGGAGTGTCGGGCATGTCTTTGTCCAGGTTT

TTGATTAGAGCCTTCCCAGATCCCGTAACAGAAAGTCTCTCATTCTGGAGATT

CATCCATGTACATGCTCGAAGTGAGCATCTGAAGGAGATGAGTGCAGTATTT GGAAACCCCGAGATAGCCAAGTTTCGAATAACTCACATAGACAAGCTAGTAG

AAGATCCAACCTCTCTGAACATCGCTATGGGAATGAGTCCAGCGAACTTGTT

AAAGACTGAGGTTAAAAAATGCTTAATCGAATCAAGACAAACCATCAGGAAC

CAGGTGATTAAGGATGCAACCATATATTTGTATCATGAAGAGGATCGGCTCA

GAAGTTTCTTATGGTCAATAAATCCTCTGTTCCCTAGATTTTTAAGTGAATTCA

AATCAGGCACTTTTTTGGGAGTCGCAGACGGGCTCATCAGTCTATTTCAAAAT

TCTCGTACTATTCGGAACTCCTTTAAGAAAAAGTATCATAGGGAATTGGATGA

TTTGATTGTGAGGAGTGAGGTATCCTCTTTGACACATTTAGGGAAACTTCATT

T GAGA AGGGGAT CAT GT A A A AT GT GGAC AT GTT C AGC T ACTC AT GCTGAC AC

ATTAAGATACAAATCCTGGGGCCGTACAGTTATTGGGACAACTGTACCCCAT

CCATTAGAAATGTTGGGTCCACAACATCGAAAAGAGACTCCTTGTGCACCAT

GTAACACATCAGGGTTCAATTATGTTTCTGTGCATTGTCCAGACGGGATCCAT

GACGTCTTTAGTTCACGGGGACCATTGCCTGCTTATCTAGGGTCTAAAACATC

TGAATCTACATCTATTTTGCAGCCTTGGGAAAGGGAAAGCAAAGTCCCACTG

ATTAAAAGAGCTACACGTCTTAGAGATGCTATCTCTTGGTTTGTTGAACCCGA

CTCTAAACTAGCAATGACTATACTTTCTAACATCCACTCTTTAACAGGCGAAG

AATGGACCAAAAGGCAGCATGGGTTCAAAAGAACAGGGTCTGCCCTTCATAG

GTTTTCGACATCTCGGATGAGCCATGGTGGGTTCGCATCTCAGAGCACTGCAG

C ATTGACC AGGTT GATGGC AACT AC AGAC ACC ATGAGGGATCTGGGAGAT C A

GAATTTCGACTTTTTATTCCAAGCAACGTTGCTCTATGCTCAAATTACCACCA

CTGTTGCAAGAGACGGATGGATCACCAGTTGTACAGATCATTATCATATTGCC

TGTAAGTCCTGTTTGAGACCCATAGAAGAGATCACCCTGGACTCAAGTATGG

ACTACACGCCCCCAGATGTATCCCATGTGCTGAAGACATGGAGGAATGGGGA

AGGTTCGTGGGGAC AAGAGAT AAAAC AGATCT ATCCTTT AGAAGGGAATTGG

AAGAATTTAGCACCTGCTGAGCAATCCTATCAAGTCGGCAGATGTATAGGTTT

TCTATATGGAGACTTGGCGTATAGAAAATCTACTCATGCCGAGGACAGTTCTC

TATTTCCTCTATCTATACAAGGTCGTATTAGAGGTCGAGGTTTCTTAAAAGGG

TTGCT AGAC GG ATT AAT GAGAGC A AGTT GCTGCC AAGT AAT AC ACCGGAGAA

GTCTGGCTCATTTGAAGAGGCCGGCCAACGCAGTGTACGGAGGTTTGATTTA

CTTGATTGATAAATTGAGTGTATCACCTCCATTCCTTTCTCTTACTAGATCAGG

ACCTATTAGAGACGAATTAGAAACGATTCCCCACAAGATCCCAACCTCCTAT

CCGACAAGCAACCGTGATATGGGGGTGATTGTCAGAAATTACTTCAAATACC

AATGCCGTCTAATTGAAAAGGGAAAATACAGATCACATTATTCACAATTATG

GTTATTCTCAGATGTCTTATCCATAGACTTCATTGGACCATTCTCTATTTCCAC CACCCTCTTGCAAATCCTATACAAGCCATTTTTATCTGGGAAAGATAAGAATG

AGTTGAGAGAGCTGGCAAATCTTTCTTCATTGCTAAGATCAGGAGAGGGGTG

GGA AGAC AT AC AT GT GA A ATTC TT C AC C A AGGAC AT ATT ATT GT GT C C AGAG

GAAAT C AG AC AT GCTTGC AAGTTCGGGATTGCT AAGGAT AAT A AT AAAGAC A

TGAGCTATCCCCCTTGGGGAAGGGAATCCAGAGGGACAATTACAACAATCCC

TGTTTATTATACGACCACCCCTTACCCAAAGATGCTAGAGATGCCTCCAAGAA

TCCAAAATCCCCTGCTGTCCGGAATCAGGTTGGGCCAATTACCAACTGGCGCT

CATTATAAAATTCGGAGTATATTACATGGAATGGGAATCCATTACAGGGACTT

CTTGAGTTGTGGAGACGGCTCCGGAGGGATGACTGCTGCATTACTACGAGAA

AATGTGCATAGCAGAGGAATATTCAATAGTCTGTTAGAATTATCAGGGTCAG

TCATGCGAGGCGCCTCTCCTGAGCCCCCCAGTGCCCTAGAAACTTTAGGAGG

AG AT A A AT C GAG AT GT GT A A AT GGT G A A AC AT GT T GGG A AT ATCCATCT G AC

TTATGTGACCCAAGGACTTGGGACTATTTCCTCCGACTCAAAGCAGGCTTGGG

GCTTCAAATTGATTTAATTGTAATGGATATGGAAGTTCGGGATTCTTCTACTA

GCCTGAAAATTGAGACGAATGTTAGAAATTATGTGCACCGGATTTTGGATGA

GC A AGGAGTTTT AATCT AC AAGACTT AT GGAAC AT AT ATTTGT GAGAGCGAA

A AG A AT GC AGT A AC A AT C CTT GGTCC C AT GTT C A AGAC GGTCGAC TT AGTT C A

AACAGAATTTAGTAGTTCTCAAACGTCTGAAGTATATATGGTATGTAAAGGTT

TGAAGAAATTAATCGATGAACCCAATCCCGATTGGTCTTCCATCAATGAATCC

TGGAAAAACCTGTACGCATTCCAGTCATCAGAACAGGAATTTGCCAGAGCAA

AGAAGGTTAGTACATACTTTACCTTGACAGGTATTCCCTCCCAATTCATTCCT

GATCCTTTTGTAAACATTGAGACTATGCTACAAATATTCGGAGTACCCACGGG

TGTGTCTCATGCGGCTGCCTTAAAATCATCTGATAGACCTGCAGATTTATTGA

CCATTAGCCTTTTTTATATGGCGATTATATCGTATTATAACATCAATCATATCA

GAGTAGGACCGATACCTCCGAACCCCCCATCAGATGGAATTGCACAAAATGT

GGGGATCGCTATAACTGGTATAAGCTTTTGGCTGAGTTTGATGGAGAAAGAC

ATTCCACTATATCAACAGTGTTTAGCAGTTATCCAGCAATCATTCCCGATTAG

GT GGGAGGCTGTTTC AGT AAAAGGAGGAT AC AAGC AGAAGT GGAGT ACT AG

AGGTGATGGGCTCCCAAAAGATACCCGAACTTCAGACTCCTTGGCCCCAATC

GGGAACTGGATCAGATCTCTGGAATTGGTCCGAAACCAAGTTCGTCTAAATC

CATTCAATGAGATCTTGTTCAATCAGCTATGTCGTACAGTGGATAATCATTTG

AAAT GGT C AAATTT GCGAAGAAAC AC AGGAAT GATT GAAT GGATC AAT AGAC

GAATTTCAAAAGAAGACCGGTCTATACTGATGTTGAAGAGTGACCTACACGA

GGA A A AC TC TT GGAGAGATT A A A A A AT CAT GAGGAGACTCC A A AC TTT A AGT ATGAAAAAAACTTTGATCCTTAAGACCCTCTTGTGGTTTTTATTTTTTATCTGG

TTTTGTGGTCTTCGT.

In one embodiment, the nucleic acid comprises the sequence of SEQ ID NO: 22, shown below (VSV vector: Convac V3 China):

ACGAAGAC AAAC AAACC ATT ATT AT C ATT AAAAGGCTC AGGAGAAACTTT AA

C AGT AAT C AAA ATGTCTGTT AC AGTC AAGAGAAT C ATTGAC AAC AC AGTC AT

AGTTCCAAAACTTCCTGCAAATGAGGATCCAGTGGAATACCCGGCAGATTAC

TTCAGAAAATCAAAGGAGATTCCTCTTTACATCAATACTACAAAAAGTTTGTC

AGATCTAAGAGGATATGTCTACCAAGGCCTCAAATCCGGAAATGTATCAATC

AT AC AT GT C A AC AGC T AC TT GT AT GG AGC ATT A A AGG AC ATC C GGGGT A AGT

TGGATAAAGATTGGTCAAGTTTCGGAATAAACATCGGGAAAGCAGGGGATAC

AATCGGAATATTTGACCTTGTATCCTTGAAAGCCCTGGACGGCGTACTTCCAG

AT GGAGT ATCGGAT GCTTCC AGAACC AGCGC AGAT GAC AAAT GGTT GCCTTT

GTATCTACTTGGCTTATACAGAGTGGGCAGAACACAAATGCCTGAATACAGA

A A A A AGC TC AT GGAT GGGC T GAC A A AT C A AT GCA A A AT GAT C A AT GA AC AGT

TTGAACCTCTTGTGCCAGAAGGTCGTGACATTTTTGATGTGTGGGGAAATGAC

AGTAATTACACAAAAATTGTCGCTGCAGTGGACATGTTCTTCCACATGTTCAA

AAAACATGAATGTGCCTCGTTCAGATACGGAACTATTGTTTCCAGATTCAAAG

ATTGTGCTGCATTGGCAACATTTGGACACCTCTGCAAAATAACCGGAATGTCT

ACAGAAGATGTAACGACCTGGATCTTGAACCGAGAAGTTGCAGATGAAATGG

TCCAAATGATGCTTCCAGGCCAAGAAATTGACAAGGCCGATTCATACATGCC

TTATTTGATCGACTTTGGATTGTCTTCTAAGTCTCCATATTCTTCCGTCAAAAA

CCCTGCCTTCCACTTCTGGGGGCAATTGACAGCTCTTCTGCTCAGATCCACCA

GAGCAAGGAATGCCCGACAGCCTGATGACATTGAGTATACATCTCTTACTAC

AGCAGGTTTGTTGTACGCTTATGCAGTAGGATCCTCTGCCGACTTGGCACAAC

AGTTTTGTGTTGGAGATAACAAATACACTCCAGATGATAGTACCGGAGGATT

GACGACTAATGCACCGCCACAAGGCAGAGATGTGGTCGAATGGCTCGGATGG

T TT G A AG AT C A A A AC AG A A A AC C GAC TC C T GAT AT GAT GC AGT AT GC G A A A A

GAGCAGTCATGTCACTGCAAGGCCTAAGAGAGAAGACAATTGGCAAGTATGC

TAAGTCAGAATTTGACAAATGACCCTATAATTCTCAGATCACCTATTATATAT

TATGCTACATATGAAAAAAACTAACAGATATCATGGATAATCTCACAAAAGT

TCGTGAGTATCTCAAGTCCTATTCTCGTCTGGATCAGGCGGTAGGAGAGATAG

ATGAGATCGAAGCACAACGAGCTGAAAAGTCCAATTATGAGTTGTTCCAAGA

GGATGGAGTGGAAGAGCATACTAAGCCCTCTTATTTTCAGGCAGCAGATGAT TCTGAC AC AGA AT C T GA AC C AG A A ATT GA AG AC A AT C A AGGTTT GT AT GC AC

CAGATCCAGAAGCTGAGCAAGTTGAAGGCTTTATACAGGGGCCTTTAGATGA

CT AT GC AGAT GAGGAAGT GGAT GTT GT ATTT ACTTCGGACTGGAAAC AGCCT

GAGCTTGAATCTGACGAGCATGGAAAGACCTTACGGTTGACATCGCCAGAGG

GTTTAAGTGGAGAGCAGAAATCCCAGTGGCTTTCGACGATTAAAGCAGTCGT

GC AAAGTGCC AAAT ACTGGAATCTGGC AGAGT GC AC ATTTGAAGC ATCGGGA

G A AGGGGT C AT T AT G A AGG AGC GC C AG AT A AC T C C GGAT GT AT AT A AGGT C A

CTCCAGTGATGAACACACATCCGTCCCAATCAGAAGCAGTATCAGATGTTTG

GTCTCTCTCAAAGACATCCATGACTTTCCAACCCAAGAAAGCAAGTCTTCAGC

CTCTCACCATATCCTTGGATGAATTGTTCTCATCTAGAGGAGAGTTCATCTCT

GTCGGAGGTGACGGACGAATGTCTCATAAAGAGGCCATCCTGCTCGGCCTGA

GATACAAAAAGTTGTACAATCAGGCGAGAGTCAAATATTCTCTGTAGACTAT

GAAAAAAAGTAACAGATATCACGATCTAAGTGTTATCCCAATCCATTCATCA

T G AGTT C C TT A A AG A AG AT TC TC GGT C T G A AGGGG A A AGGT A AG A A AT C T A A

GAAATTAGGGATCGCACCACCCCCTTATGAAGAGGACACTAGCATGGAGTAT

GCTCCGAGCGCTCCAATTGACAAATCCTATTTTGGAGTTGACGAGATGGACA

CCTATGATCCGAATCAATTAAGATATGAGAAATTCTTCTTTACAGTGAAAATG

ACGGTTAGATCTAATCGTCCGTTCAGAACATACTCAGATGTGGCAGCCGCTGT

ATCCCATTGGGATCACATGTACATCGGAATGGCAGGGAAACGTCCCTTCTAC

AAAATCTTGGCTTTTTTGGGTTCTTCTAATCTAAAGGCCACTCCAGCGGTATT

GGCAGATCAAGGTCAACCAGAGTATCACACTCACTGCGAAGGCAGGGCTTAT

TTGCCACATAGGATGGGGAAGACCCCTCCCATGCTCAATGTACCAGAGCACT

T C AGAAGACC ATTC AAT AT AGGTCTTT AC AAGGGAACGATTGAGCTC AC A AT

GACCATCTACGATGATGAGTCACTGGAAGCAGCTCCTATGATCTGGGATCATT

TCAATTCTTCCAAATTTTCTGATTTCAGAGAGAAGGCCTTAATGTTTGGCCTG

ATTGTCGAGAAAAAGGCATCTGGAGCGTGGGTCCTGGATTCTATCAGCCACT

TCAAATGAGCTAGTCTAACTTCTAGCTTCTGAACAATCCCCGGTTTACTCAGT

CTCTCCTAATTCCAGCCTCTCGAACAACTAATATCCTGTCTTTTCTATCCCTAT

GAAAAAAACTAACAGAGATCGATCTGTTTACGCGTCACTATGAAGTGCCTTTT

GTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCC

ACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGC

CCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCATAC

A AGT C A A A AT GCC C A AGAGTC AC A AGGC T ATT C A AGC AGACGGTT GGAT GT G

TCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGT ATATAACACAGTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGA

AAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCT

C AAAGTT GTGGAT AT GC AACTGT GACGGAT GCCGAAGC AGT GATTGTCC AGG

TGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCA

CAGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTC

TACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCA

TTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGA

AAGGAGGGC AC AGGGTT C AGAAGT AACT ACTTTGCTT AT GAAACTGGAGGC A

AGGCCTGC AAAAT GC AAT ACTGC AAGC ATT GGGGAGTC AGACTCCC ATC AGG

TGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTG

AATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTA

AGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAAC

CTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATC

TTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACC

CTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCT

C T C A AG A AT GGT C GG A AT GAT C AGT GG A AC T AC C AC AG A A AGGG A AC TGT GG

GAT GACTGGGC ACC AT AT GAAGACGT GGAAATTGGACCC AAT GGAGTTCTGA

GGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTG

GACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACAT

TCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATA

CTGGGCT ATCC AAAAATCC AATCGAGCTTGT AGAAGGTT GGTTC AGT AGTT G

GAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATT

CTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGA

AAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACTCAA

ATCCTGCT AGGT ATGA AAAAAACT AACaGAT ATC ACGCtcgagGCC ACC AT GTT C

GTGTTTCTGGTGCTGCTGCCTCTGGTGAGCTCCCAGTGCGTGAACCTGACCAC

AAGGACCCAGCTGCCCCCTGCCTATACCAATTCCTTCACACGGGGCGTGTACT

ATCCCGACAAGGTGTTCCGGAGCAGCGTGCTGCACTCCACACAGGATCTGTTT

CTGCCTTTCTTTTCTAACGTGACCTGGTTCCACGCCATCCACGTGAGCGGCAC

CAATGGCACAAAGCGGTTCGACAATCCAGTGCTGCCCTTTAACGATGGCGTG

TACTTCGCCTCCACCGAGAAGTCTAACATCATCAGAGGCTGGATCTTTGGCAC

CACACTGGACAGCAAGACACAGTCCCTGCTGATCGTGAACAATGCCACCAAC

GTGGTCATCAAGGTGTGCGAGTTCCAGTTTTGTAATGATCCATTCCTGGGCGT

GT ACT AT C AC A AG A AC A AT A AGT C TT GGAT GGAGAGCG AGTTTC GCGT GT AT TCCTCTGCCAACAATTGCACATTTGAGTACGTGTCCCAGCCCTTCCTGATGGA

CCTGGAGGGCAAGCAGGGCAATTTCAAGAACCTGAGGGAGTTCGTGTTTAAG

AATATCGATGGCTACTTCAAAATCTACTCCAAGCACACCCCAATCAACCTGGT

GCGCGACCTGCCACAGGGCTTCTCTGCCCTGGAGCCACTGGTGGATCTGCCCA

TCGGCATCAACATCACCCGGTTTCAGACACTGCTGGCCCTGCACAGAAGCTA

CCTGACACCAGGCGACAGCTCCTCTGGATGGACCGCAGGAGCAGCAGCCTAC

TATGTGGGCTATCTGCAGCCCAGGACCTTCCTGCTGAAGTACAACGAGAATG

GCACCATCACAGACGCCGTGGATTGCGCCCTGGATCCCCTGTCTGAGACCAA

GTGTACACTGAAGAGCTTTACCGTGGAGAAGGGCATCTATCAGACAAGCAAT

TTCAGGGTGCAGCCTACCGAGTCCATCGTGCGCTTTCCCAATATCACAAACCT

GTGCCCTTTTGGCGAGGTGTTCAACGCAACCCGCTTCGCCAGCGTGTACGCCT

GGAATAGGAAGCGCATCTCCAACTGCGTGGCCGACTATTCTGTGCTGTACAA

CAGCGCCTCCTTCTCTACCTTTAAGTGCTATGGCGTGAGCCCCACAAAGCTGA

ATGACCTGTGCTTTACCAACGTGTACGCCGATTCCTTCGTGATCAGGGGCGAC

GAGGTGCGCCAGATCGCACCAGGACAGACAGGCAAGATCGCAGACTACAAT

TATAAGCTGCCTGACGATTTCACCGGCTGCGTGATCGCCTGGAACTCTAACAA

TCTGGATAGCAAAGTGGGCGGCAACTACAATTATCTGTACCGGCTGTTTAGA

AAGTCTAATCTGAAGCCATTCGAGAGGGACATCTCCACAGAAATCTACCAGG

CCGGCTCTACCCCCTGCAATGGCGTGGAGGGCTTTAACTGTTATTTCCCTCTG

CAGAGCTACGGCTTCCAGCCAACAAACGGCGTGGGCTATCAGCCCTACCGCG

TGGTGGTGCTGTCTTTTGAGCTGCTGCACGCACCTGCAACAGTGTGCGGACCA

AAGAAGAGCACCAATCTGGTGAAGAACAAGTGCGTGAACTTCAACTTCAACG

GACTGACCGGAACAGGCGTGCTGACCGAGTCCAACAAGAAGTTCCTGCCTTT

TCAGCAGTTCGGCAGGGACATCGCAGATACCACAGACGCCGTGCGCGACCCT

CAGACCCTGGAGATCCTGGACATCACACCATGCTCCTTCGGCGGCGTGTCTGT

GATCACACCAGGCACCAATACAAGCAACCAGGTGGCCGTGCTGTATCAGGAC

GTGAATTGTACCGAGGTGCCAGTGGCAATCCACGCAGATCAGCTGACCCCTA

CAT GGCGGGTGT ACTCT ACCGGC AGC AACGT GTTCC AGAC AAGAGCCGGATG

CCTGATCGGAGCAGAGCACGTGAACAATAGCTATGAGTGCGACATCCCTATC

GGCGCCGGCATCTGTGCCTCCTACCAGACCCAGACAAACTCCCCAAGGTCTG

GATCCGGCTACATCCCCGAGGCCCCCAGAGACGGCCAGGCCTACGTGCGGAA

GGACGGCGAGTGGGTACTGctcagcaccttcctgggcAGCAGTTGGAAAAGCTCCATCG

CCTCCTTTTTCTTTATCATCGGCCTGATCATCGGACTGTTCCTGGTGCTCCGCG

T GGGT ATCC ACCTGT GC AT C AAGCTGAAGC AC ACC AAGA AAAGAC AGATTT A TACAGACATCGAGATGAACCGACTTGGAAAGTAAGCTAGCCAGATTCTTCAT

GTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATT

TGAGTTTTTAATTTTTATGAAAAAAACTAACAGCAATCATGGAAGTCCACGAT

TTTGAGACCGACGAGTTCAATGATTTCAATGAAGATGACTATGCCACAAGAG

AATTCCTGAATCCCGATGAGCGCATGACGTACTTGAATCATGCTGATTACAAT

TTGAATTCTCCTCTAATTAGTGATGATATTGACAATTTGATCAGGAAATTCAA

TTCTCTTCCGATTCCCTCGATGTGGGATAGTAAGAACTGGGATGGAGTTCTTG

AGATGTTAACATCATGTCAAGCCAATCCCATCTCAACATCTCAGATGCATAAA

T GGAT GGGA AGTT GGTT A AT GTCTG AT A AT CAT GAT GC C AGT C A AGGGT AT A

_{GTTTTTTACATGAAGTGGACAAAGAGGCAGAAATAACATTTGACGTGGTGGA}

GACCTTCATCCGCGGCTGGGGCAACAAACCAATTGAATACATCAAAAAGGAA

AGATGGACTGACTCATTCAAAATTCTCGCTTATTTGTGTCAAAAGTTTTTGGA

CTTACACAAGTTGACATTAATCTTAAATGCTGTCTCTGAGGTGGAATTGCTCA

ACTTGGCGAGGACTTT C AAAGGC AAAGT C AGAAGAAGTTCTC AT GGAACGAA

CATATGCAGGATTAGGGTTCCCAGCTTGGGTCCTACTTTTATTTCAGAAGGAT

GGGCTTACTTCAAGAAACTTGATATTCTAATGGACCGAAACTTTCTGTTAATG

GT C A A AG AT GT GATT AT AGGGAGGAT GC A A ACGGT GCT AT C CAT GGT AT GT A

GAATAGACAACCTGTTCTCAGAGCAAGACATCTTCTCCCTTCTAAATATCTAC

AGAATTGGAGATAAAATTGTGGAGAGGCAGGGAAATTTTTCTTATGACTTGA

TTAAAATGGTGGAACCGATATGCAACTTGAAGCTGATGAAATTAGCAAGAGA

ATCAAGGCCTTTAGTCCCACAATTCCCTCATTTTGAAAATCATATCAAGACTT

CTGTTGATGAAGGGGCAAAAATTGACCGAGGTATAAGATTCCTCCATGATCA

GAT AATGAGT GT GAAAAC AGT GGATCTC AC ACTGGT GATTT ATGGATCGTTC A

GACATTGGGGTCATCCTTTTATAGATTATTACACTGGACTAGAAAAATTACAT

TCCC A AGT A AC CAT GA AG A A AG AT ATT GAT GT GTC AT AT GC A A A AGC AC TTG

CAAGTGATTTAGCTCGGATTGTTCTATTTCAACAGTTCAATGATCATAAAAAG

TGGTTCGTGAATGGAGACTTGCTCCCTCATGATCATCCCTTTAAAAGTCATGT

TAAAGAAAATACATGGCCCACAGCTGCTCAAGTTCAAGATTTTGGAGATAAA

TGGCATGAACTTCCGCTGATTAAATGTTTTGAAATACCCGACTTACTAGACCC

ATCGATAATATACTCTGACAAAAGTCATTCAATGAATAGGTCAGAGGTGTTG

AAACATGTCCGAATGAATCCGAACACTCCTATCCCTAGTAAAAAGGTGTTGC

AGACTATGTTGGACACAAAGGCTACCAATTGGAAAGAATTTCTTAAAGAGAT

T GAT G AG A AGGGC T T AG AT GAT GAT GAT C T A AT T ATT GGT C TT A A AGG A A AG

GAGAGGGAACTGAAGTTGGCAGGTAGATTTTTCTCCCTAATGTCTTGGAAATT GCGAGAATACTTTGTAATTACCGAATATTTGATAAAGACTCATTTCGTCCCTA

TGTTTAAAGGCCTGACAATGGCGGACGATCTAACTGCAGTCATTAAAAAGAT

GTTAGATTCCTCATCCGGCCAAGGATTGAAGTCATATGAGGCAATTTGCATAG

CCAATCACATTGATTACGAAAAATGGAATAACCACCAAAGGAAGTTATCAAA

CGGCCCAGTGTTCCGAGTTATGGGCCAGTTCTTAGGTTATCCATCCTTAATCG

AGAGAACTCATGAATTTTTTGAGAAAAGTCTTATATACTACAATGGAAGACC

AGACTTGATGCGTGTTCACAACAACACACTGATCAATTCAACCTCCCAACGA

GTTT GTT GGC AAGGAC AAGAGGGT GGACTGGAAGGTCT ACGGC AAAAAGGA

T GGACT ATCCTC AATCT ACTGGTT ATT C AA AGAGAGGCT AAAAT C AGAA AC A

CTGCTGT C AAAGTCTTGGC AC AAGGT GAT AATC AAGTT ATTTGC AC AC AGT AT

AAAACGAAGAAATCGAGA AACGTTGT AGAATT AC AGGGT GCTCTC AATC AAA

T GGTT T C T A AT A AT GAG A A A AT TAT G AC T GC A AT C AAAAT AGGG AC AGGG A A

GTT AGGACTTTT GAT AAAT GACGAT GAGACT AT GC AATCTGC AGATT ACTT GA

ATTATGGAAAAATACCGATTTTCCGTGGAGTGATTAGAGGGTTAGAGACCAA

GAGATGGTCACGAGTGACTTGTGTCACCAATGACCAAATACCCACTTGTGCT

AATATAATGAGCTCAGTTTCCACAAATGCTCTCACCGTAGCTCATTTTGCTGA

GAACCC AAT C AAT GCC ATGAT AC AGT AC AATT ATTTTGGGAC ATTT GCT AGAC

TCTTGTTGATGATGCATGATCCTGCTCTTCGTCAATCATTGTATGAAGTTCAAG

ATAAGATACCGGGCTTGCACAGTTCTACTTTCAAATACGCCATGTTGTATTTG

GACCCTTCCATTGGAGGAGTGTCGGGCATGTCTTTGTCCAGGTTTTTGATTAG

AGCCTTCCCAGATCCCGTAACAGAAAGTCTCTCATTCTGGAGATTCATCCATG

T AC AT GC T C GA AGT GAGC ATCTGA AGGAGAT GAGT GC AGT ATTT GGA A AC CC

CGAGAT AGCC AAGTTTCGAAT AACTC AC AT AGAC AAGCT AGT AGAAGATCC A

ACCTCTCTGAACATCGCTATGGGAATGAGTCCAGCGAACTTGTTAAAGACTG

AGGTT A A A A A AT GC TT A ATCGA AT C A AG AC A A AC CAT C AGGA AC C AGGT GAT

TAAGGATGCAACCATATATTTGTATCATGAAGAGGATCGGCTCAGAAGTTTCT

TATGGTCAATAAATCCTCTGTTCCCTAGATTTTTAAGTGAATTCAAATCAGGC

ACTTTTTTGGGAGTCGCAGACGGGCTCATCAGTCTATTTCAAAATTCTCGTAC

T ATTCGGAACTCCTTT AAGAAAAAGT AT CAT AGGG AATT GGAT GATTT GATT G

TGAGGAGTGAGGTATCCTCTTTGACACATTTAGGGAAACTTCATTTGAGAAGG

GGATCATGTAAAATGTGGACATGTTCAGCTACTCATGCTGACACATTAAGAT

ACAAATCCTGGGGCCGTACAGTTATTGGGACAACTGTACCCCATCCATTAGA

AATGTTGGGTCCACAACATCGAAAAGAGACTCCTTGTGCACCATGTAACACA

TCAGGGTTCAATTATGTTTCTGTGCATTGTCCAGACGGGATCCATGACGTCTT TAGTTCACGGGGACCATTGCCTGCTTATCTAGGGTCTAAAACATCTGAATCTA

C ATCT ATTTT GC AGCCTTGGGAAAGGGAAAGC AAAGTCCC ACTGATT AAA AG

AGCTACACGTCTTAGAGATGCTATCTCTTGGTTTGTTGAACCCGACTCTAAAC

TAGCAATGACTATACTTTCTAACATCCACTCTTTAACAGGCGAAGAATGGACC

AAAAGGC AGC AT GGGTTC AAAAGAAC AGGGTCTGCCCTT CAT AGGTTTTCGA

CATCTCGGATGAGCCATGGTGGGTTCGCATCTCAGAGCACTGCAGCATTGAC

C AGGTT GATGGC AACT AC AGAC ACC ATGAGGGATCTGGGAGAT C AGAATTTC

GACTTTTTATTCCAAGCAACGTTGCTCTATGCTCAAATTACCACCACTGTTGC

A AG AG AC GGAT GGAT C AC C AGTT GT AC AGATC ATT ATC AT ATTGC CTGT A AG

TCCTGTTTGAGACCCATAGAAGAGATCACCCTGGACTCAAGTATGGACTACA

CGCCCCCAGATGTATCCCATGTGCTGAAGACATGGAGGAATGGGGAAGGTTC

GT GGGGAC A AG AGAT A A A AC AG AT C T ATCC TTT AGA AGGGA ATTGGA AGA AT

TTAGCACCTGCTGAGCAATCCTATCAAGTCGGCAGATGTATAGGTTTTCTATA

TGGAGACTTGGCGTATAGAAAATCTACTCATGCCGAGGACAGTTCTCTATTTC

CTCTATCTATACAAGGTCGTATTAGAGGTCGAGGTTTCTTAAAAGGGTTGCTA

GACGGATTAATGAGAGCAAGTTGCTGCCAAGTAATACACCGGAGAAGTCTGG

CTCATTTGAAGAGGCCGGCCAACGCAGTGTACGGAGGTTTGATTTACTTGATT

GATAAATTGAGTGTATCACCTCCATTCCTTTCTCTTACTAGATCAGGACCTATT

AGAGACGAATTAGAAACGATTCCCCACAAGATCCCAACCTCCTATCCGACAA

GCAACCGTGATATGGGGGTGATTGTCAGAAATTACTTCAAATACCAATGCCG

TCT AATTGAAAAGGGAAAAT AC AGAT C AC ATT ATT C AC AATT AT GGTT ATTCT

CAGATGTCTTATCCATAGACTTCATTGGACCATTCTCTATTTCCACCACCCTCT

TGCAAATCCTATACAAGCCATTTTTATCTGGGAAAGATAAGAATGAGTTGAG

AGAGCTGGC AAATCTTTCTTC ATT GCT AAGAT C AGGAGAGGGGT GGGAAGAC

AT AC AT GTGAAATTCTT C ACC AAGGAC AT ATT ATT GT GTCC AGAGGAAATC A

GACATGCTTGCAAGTTCGGGATTGCTAAGGATAATAATAAAGACATGAGCTA

TCCCCCTTGGGGAAGGGAATCCAGAGGGACAATTACAACAATCCCTGTTTAT

TATACGACCACCCCTTACCCAAAGATGCTAGAGATGCCTCCAAGAATCCAAA

ATCCCCTGCTGTCCGGAATCAGGTTGGGCCAATTACCAACTGGCGCTCATTAT

AAAATTCGGAGTATATTACATGGAATGGGAATCCATTACAGGGACTTCTTGA

GTTGTGGAGACGGCTCCGGAGGGATGACTGCTGCATTACTACGAGAAAATGT

GC AT AGC AGAGGA AT ATT C A AT AGTCTGTT AGA ATT AT C AGGGT C AGTC AT G

CGAGGCGCCTCTCCTGAGCCCCCCAGTGCCCTAGAAACTTTAGGAGGAGATA

A ATCGAGAT GT GT A A AT GGT GA A AC AT GTT GGGA AT ATCC AT C T GAC TT AT GT GACCCAAGGACTTGGGACTATTTCCTCCGACTCAAAGCAGGCTTGGGGCTTC

AAATTGATTTAATTGTAATGGATATGGAAGTTCGGGATTCTTCTACTAGCCTG

AAAATTGAGACGAAT GTT AGAAATT ATGT GC ACCGGATTTT GGAT GAGC AAG

GAGTTTTAATCTACAAGACTTATGGAACATATATTTGTGAGAGCGAAAAGAA

TGCAGTAACAATCCTTGGTCCCATGTTCAAGACGGTCGACTTAGTTCAAACAG

A ATTT AGT AGTTCTC A A AC GT C T GA AGT AT AT AT GGT AT GT A A AGGTTT GA AG

AAATTAATCGATGAACCCAATCCCGATTGGTCTTCCATCAATGAATCCTGGAA

A A AC CTGT AC GC ATTC C AGT CAT C AGA AC AGGA ATTT GCC AG AGC A A AGA AG

GTTAGTACATACTTTACCTTGACAGGTATTCCCTCCCAATTCATTCCTGATCCT

TTTGTAAACATTGAGACTATGCTACAAATATTCGGAGTACCCACGGGTGTGTC

TCATGCGGCTGCCTTAAAATCATCTGATAGACCTGCAGATTTATTGACCATTA

GCCTTTTTTATATGGCGATTATATCGTATTATAACATCAATCATATCAGAGTA

GGACCGATACCTCCGAACCCCCCATCAGATGGAATTGCACAAAATGTGGGGA

TCGCTATAACTGGTATAAGCTTTTGGCTGAGTTTGATGGAGAAAGACATTCCA

CTATATCAACAGTGTTTAGCAGTTATCCAGCAATCATTCCCGATTAGGTGGGA

GGCTGTTT C AGT A A A AGGAGGAT AC A AGC AGA AGT GG AGT AC T AGAGGT GAT

GGGCTCCCAAAAGATACCCGAACTTCAGACTCCTTGGCCCCAATCGGGAACT

GGATCAGATCTCTGGAATTGGTCCGAAACCAAGTTCGTCTAAATCCATTCAAT

GAGATCTTGTTCAATCAGCTATGTCGTACAGTGGATAATCATTTGAAATGGTC

AAATTT GCGA AGAAAC AC AGGAATGATT GAAT GGAT C AAT AGACGAATTTC A

AAAGAAGACCGGTCTATACTGATGTTGAAGAGTGACCTACACGAGGAAAACT

CTTGGAGAGATT AAAAAAT C ATGAGGAGACTCC AAACTTT AAGT AT GAAAA A

AACTTTGATCCTTAAGACCCTCTTGTGGTTTTTATTTTTTATCTGGTTTTGTGGT

CTTCGT.

In another embodiment, the nucleic acid comprises the sequence of SEQ ID NO: 23, shown below (VSV vector: Convac V3 South Africa):

ACGAAGAC AAAC AAACC ATT ATT AT C ATT AAAAGGCTCAGGAG AAACTTT AA C AGT AAT C AAA ATGTCTGTT AC AGTC AAGAGAAT C ATTGAC AAC AC AGTC AT AGTTCCAAAACTTCCTGCAAATGAGGATCCAGTGGAATACCCGGCAGATTAC TTCAGAAAATCAAAGGAGATTCCTCTTTACATCAATACTACAAAAAGTTTGTC AGATCTAAGAGGATATGTCTACCAAGGCCTCAAATCCGGAAATGTATCAATC AT AC AT GT C A AC AGC T AC TT GT AT GG AGC ATT A A AGG AC ATC C GGGGT AAGT T GGAT A A AG AT T GGT C A AGTT T C GG A AT AAAC ATC GGG A A AGC AGGGG AT AC AATCGGAATATTTGACCTTGTATCCTTGAAAGCCCTGGACGGCGTACTTCCAG AT GGAGT ATCGGAT GCTTCC AGAACC AGCGC AGAT GAC AAAT GGTT GCCTTT

GTATCTACTTGGCTTATACAGAGTGGGCAGAACACAAATGCCTGAATACAGA

A A A A AGC TC AT GGAT GGGC T GAC A A AT C A AT GCA A A AT GAT C A AT GA AC AGT

TTGAACCTCTTGTGCCAGAAGGTCGTGACATTTTTGATGTGTGGGGAAATGAC

AGTAATTACACAAAAATTGTCGCTGCAGTGGACATGTTCTTCCACATGTTCAA

AAAACATGAATGTGCCTCGTTCAGATACGGAACTATTGTTTCCAGATTCAAAG

ATTGTGCTGCATTGGCAACATTTGGACACCTCTGCAAAATAACCGGAATGTCT

ACAGAAGATGTAACGACCTGGATCTTGAACCGAGAAGTTGCAGATGAAATGG

TCCAAATGATGCTTCCAGGCCAAGAAATTGACAAGGCCGATTCATACATGCC

TTATTTGATCGACTTTGGATTGTCTTCTAAGTCTCCATATTCTTCCGTCAAAAA

CCCTGCCTTCCACTTCTGGGGGCAATTGACAGCTCTTCTGCTCAGATCCACCA

GAGCAAGGAATGCCCGACAGCCTGATGACATTGAGTATACATCTCTTACTAC

AGCAGGTTTGTTGTACGCTTATGCAGTAGGATCCTCTGCCGACTTGGCACAAC

AGTTTTGTGTTGGAGATAACAAATACACTCCAGATGATAGTACCGGAGGATT

GACGACTAATGCACCGCCACAAGGCAGAGATGTGGTCGAATGGCTCGGATGG

T TT G A AG AT C A A A AC AG A A A AC C GAC TC C T GAT AT GAT GC AGT AT GC G A A A A

GAGCAGTCATGTCACTGCAAGGCCTAAGAGAGAAGACAATTGGCAAGTATGC

TAAGTCAGAATTTGACAAATGACCCTATAATTCTCAGATCACCTATTATATAT

TATGCTACATATGAAAAAAACTAACAGATATCATGGATAATCTCACAAAAGT

TCGTGAGTATCTCAAGTCCTATTCTCGTCTGGATCAGGCGGTAGGAGAGATAG

ATGAGATCGAAGCACAACGAGCTGAAAAGTCCAATTATGAGTTGTTCCAAGA

GGATGGAGTGGAAGAGCATACTAAGCCCTCTTATTTTCAGGCAGCAGATGAT

TCTGAC AC AGA AT C T GA AC C AG A A ATT GA AG AC A AT C A AGGTTT GT AT GC AC

CAGATCCAGAAGCTGAGCAAGTTGAAGGCTTTATACAGGGGCCTTTAGATGA

CT AT GC AGAT GAGGAAGT GGAT GTT GT ATTT ACTTCGGACTGGAAAC AGCCT

GAGCTTGAATCTGACGAGCATGGAAAGACCTTACGGTTGACATCGCCAGAGG

GTTTAAGTGGAGAGCAGAAATCCCAGTGGCTTTCGACGATTAAAGCAGTCGT

GC AAAGTGCC AAAT ACTGGAATCTGGC AGAGT GC AC ATTTGAAGC ATCGGGA

G A AGGGGT C AT T AT G A AGG AGC GC C AG AT A AC T C C GGAT GT AT AT A AGGT C A

CTCCAGTGATGAACACACATCCGTCCCAATCAGAAGCAGTATCAGATGTTTG

GTCTCTCTCAAAGACATCCATGACTTTCCAACCCAAGAAAGCAAGTCTTCAGC

CTCTCACCATATCCTTGGATGAATTGTTCTCATCTAGAGGAGAGTTCATCTCT

GTCGGAGGTGACGGACGAATGTCTCATAAAGAGGCCATCCTGCTCGGCCTGA

GATACAAAAAGTTGTACAATCAGGCGAGAGTCAAATATTCTCTGTAGACTAT GAAAAAAAGTAACAGATATCACGATCTAAGTGTTATCCCAATCCATTCATCA

T G AGTT C C TT A A AG A AG AT TC TC GGT C T G A AGGGG A A AGGT A AG A A AT C T A A

GAAATTAGGGATCGCACCACCCCCTTATGAAGAGGACACTAGCATGGAGTAT

GCTCCGAGCGCTCCAATTGACAAATCCTATTTTGGAGTTGACGAGATGGACA

CCTATGATCCGAATCAATTAAGATATGAGAAATTCTTCTTTACAGTGAAAATG

ACGGTTAGATCTAATCGTCCGTTCAGAACATACTCAGATGTGGCAGCCGCTGT

ATCCCATTGGGATCACATGTACATCGGAATGGCAGGGAAACGTCCCTTCTAC

AAAATCTTGGCTTTTTTGGGTTCTTCTAATCTAAAGGCCACTCCAGCGGTATT

GGCAGATCAAGGTCAACCAGAGTATCACACTCACTGCGAAGGCAGGGCTTAT

TTGCCACATAGGATGGGGAAGACCCCTCCCATGCTCAATGTACCAGAGCACT

T C AGAAGACC ATTC AAT AT AGGTCTTT AC AAGGGAACGATTGAGCTC AC A AT

GACCATCTACGATGATGAGTCACTGGAAGCAGCTCCTATGATCTGGGATCATT

TCAATTCTTCCAAATTTTCTGATTTCAGAGAGAAGGCCTTAATGTTTGGCCTG

ATTGTCGAGAAAAAGGCATCTGGAGCGTGGGTCCTGGATTCTATCAGCCACT

TCAAATGAGCTAGTCTAACTTCTAGCTTCTGAACAATCCCCGGTTTACTCAGT

CTCTCCTAATTCCAGCCTCTCGAACAACTAATATCCTGTCTTTTCTATCCCTAT

GAAAAAAACTAACAGAGATCGATCTGTTTACGCGTCACTATGAAGTGCCTTTT

GTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCC

ACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGC

CCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCATAC

A AGT C A A A AT GCC C A AGAGTC AC A AGGC T ATT C A AGC AGACGGTT GGAT GT G

TCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGT

ATATAACACAGTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGA

AAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCT

C AAAGTT GTGGAT AT GC AACTGT GACGGAT GCCGAAGC AGT GATTGTCC AGG

TGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCA

CAGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTC

TACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCA

TTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGA

AAGGAGGGC AC AGGGTT C AGAAGT AACT ACTTTGCTT AT GAAACTGGAGGC A

AGGCCTGC AAAAT GC AAT ACTGC AAGC ATT GGGGAGTC AGACTCCC ATC AGG

TGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTG

AATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTA

AGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAAC CTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATC

TTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACC

CTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCT

C T C A AG A AT GGT C GG A AT GAT C AGT GG A AC T AC C AC AG A A AGGG A AC TGT GG

GAT GACTGGGC ACC AT AT GAAGACGT GGAAATTGGACCC AAT GGAGTTCTGA

GGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTG

GACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACAT

TCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATA

CTGGGCT ATCC AAAAATCC AATCGAGCTTGT AGAAGGTT GGTTC AGT AGTT G

GAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATT

CTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGA

AAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACTCAA

ATCCTGCT AGGT ATGA AAAAAACT AACaGAT ATC ACGCtcgagGCC ACC AT GTT C

GTGTTTCTGGTGCTGCTGCCTCTGGTGAGCTCCCAGTGCGTGAACTTCACCAC

AAGGACCCAGCTGCCCCCTGCCTATACCAATTCCTTCACACGGGGCGTGTACT

ATCCCGACAAGGTGTTCCGGAGCAGCGTGCTGCACTCCACACAGGATCTGTTT

CTGCCTTTCTTTTCTAACGTGACCTGGTTCCACGCCATCCACGTGAGCGGCAC

CAATGGCACAAAGCGGTTCGCCAATCCAGTGCTGCCCTTTAACGATGGCGTG

TACTTCGCCTCCACCGAGAAGTCTAACATCATCAGAGGCTGGATCTTTGGCAC

CACACTGGACAGCAAGACACAGTCCCTGCTGATCGTGAACAATGCCACCAAC

GTGGTCATCAAGGTGTGCGAGTTCCAGTTTTGTAATGATCCATTCCTGGGCGT

GT ACT AT C AC A AG A AC A AT A AGT C TT GGAT GGAGAGCG AGTTTC GCGT GT AT

TCCTCTGCCAACAATTGCACATTTGAGTACGTGTCCCAGCCCTTCCTGATGGA

CCTGGAGGGCAAGCAGGGCAATTTCAAGAACCTGAGGGAGTTCGTGTTTAAG

AATATCGATGGCTACTTCAAAATCTACTCCAAGCACACCCCAATCAACCTGGT

GCGCGGCCTGCCACAGGGCTTCTCTGCCCTGGAGCCACTGGTGGATCTGCCCA

TCGGCATCAACATCACCCGGTTTCAGACACTGCTGGCCCTGCACAGAAGCTA

CCTGACACCAGGCGACAGCTCCTCTGGATGGACCGCAGGAGCAGCAGCCTAC

TATGTGGGCTATCTGCAGCCCAGGACCTTCCTGCTGAAGTACAACGAGAATG

GCACCATCACAGACGCCGTGGATTGCGCCCTGGATCCCCTGTCTGAGACCAA

GTGTACACTGAAGAGCTTTACCGTGGAGAAGGGCATCTATCAGACAAGCAAT

TTCAGGGTGCAGCCTACCGAGTCCATCGTGCGCTTTCCCAATATCACAAACCT

GTGCCCTTTTGGCGAGGTGTTCAACGCAACCCGCTTCGCCAGCGTGTACGCCT

GGAATAGGAAGCGCATCTCCAACTGCGTGGCCGACTATTCTGTGCTGTACAA CAGCGCCTCCTTCTCTACCTTTAAGTGCTATGGCGTGAGCCCCACAAAGCTGA

ATGACCTGTGCTTTACCAACGTGTACGCCGATTCCTTCGTGATCAGGGGCGAC

GAGGTGCGCCAGATCGCACCAGGACAGACAGGCAATATCGCAGACTACAATT

ATAAGCTGCCTGACGATTTCACCGGCTGCGTGATCGCCTGGAACTCTAACAAT

CTGGATAGCAAAGTGGGCGGCAACTACAATTATCTGTACCGGCTGTTTAGAA

AGTCTAATCTGAAGCCATTCGAGAGGGACATCTCCACAGAAATCTACCAGGC

CGGCTCTACCCCCTGCAATGGCGTGAAGGGCTTTAACTGTTATTTCCCTCTGC

AGAGCTACGGCTTCCAGCCAACATATGGCGTGGGCTATCAGCCCTACCGCGT

GGTGGTGCTGTCTTTTGAGCTGCTGCACGCACCTGCAACAGTGTGCGGACCAA

AGAAGAGC ACC AATCTGGTGAAGA AC AAGT GCGT GAACTTC AACTTC AACGG

ACTGACCGGAACAGGCGTGCTGACCGAGTCCAACAAGAAGTTCCTGCCTTTT

CAGCAGTTCGGCAGGGACATCGCAGATACCACAGACGCCGTGCGCGACCCTC

AGACCCTGGAGATCCTGGACATCACACCATGCTCCTTCGGCGGCGTGTCTGTG

AT C AC ACC AGGC ACC AAT AC AAGC AACC AGGT GGCCGTGCTGT ATC AGGGCG

TGAATTGTACCGAGGTGCCAGTGGCAATCCACGCAGATCAGCTGACCCCTAC

AT GGCGGGT GT ACTCT ACCGGC AGC AACGT GTTCC AGAC AAGAGCCGGATGC

CTGATCGGAGCAGAGCACGTGAACAATAGCTATGAGTGCGACATCCCTATCG

GCGCCGGCATCTGTGCCTCCTACCAGACCCAGACAAACTCCCCAAGGGGATC

CGGCTACATCCCCGAGGCCCCCAGAGACGGCCAGGCCTACGTGCGGAAGGAC

GGCGAGT GGGT ACTGctcagcaccttcctgggc AGC AGTTGGAAAAGCTCC ATCGCCTC

CTTTTTCTTTATCATCGGCCTGATCATCGGACTGTTCCTGGTGCTCCGCGTGGG

TATCCACCTGTGCATCAAGCTGAAGCACACCAAGAAAAGACAGATTTATACA

GACATCGAGATGAACCGACTTGGAAAGTAAGCTAGCCAGATTCTTCATGTTT

GGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCCTCAATTATATTTGA

GTTTTTAATTTTTATGAAAAAAACTAACAGCAATCATGGAAGTCCACGATTTT

GAGACCGACGAGTTCAATGATTTCAATGAAGATGACTATGCCACAAGAGAAT

TCCTGAATCCCGATGAGCGCATGACGTACTTGAATCATGCTGATTACAATTTG

AATTCTCCTCTAATTAGTGATGATATTGACAATTTGATCAGGAAATTCAATTC

TCTTCCGATTCCCTCGATGTGGGATAGTAAGAACTGGGATGGAGTTCTTGAGA

TGTTAACATCATGTCAAGCCAATCCCATCTCAACATCTCAGATGCATAAATGG

AT GGGAAGTT GGTT AAT GTCTGAT AAT CAT GAT GCC AGTC AAGGGT AT AGTTT

TTT AC AT GAAGT GGAC AAAGAGGC AGAAAT A AC ATTT GACGT GGT GGAGACC

TT C ATCCGCGGCTGGGGC AAC AAACC AATT GAAT AC AT C AAAAAGGAAAGAT

GGACTGACTCATTCAAAATTCTCGCTTATTTGTGTCAAAAGTTTTTGGACTTAC ACAAGTTGACATTAATCTTAAATGCTGTCTCTGAGGTGGAATTGCTCAACTTG

GCGAGGACTTT C AAAGGC AAAGT C AGAAGAAGTTCTC AT GGAACGAAC AT AT

GCAGGATTAGGGTTCCCAGCTTGGGTCCTACTTTTATTTCAGAAGGATGGGCT

TACTTCAAGAAACTTGATATTCTAATGGACCGAAACTTTCTGTTAATGGTCAA

AG AT GT GATT AT AGGG AGGAT GCA A AC GGT GC T ATCC AT GGT AT GT AGA AT A

GACAACCTGTTCTCAGAGCAAGACATCTTCTCCCTTCTAAATATCTACAGAAT

T GGAGAT AAAATT GT GGAGAGGC AGGGAAATTTTTCTT ATGACTT GATT AAA

AT GGT GG A AC C GAT AT GCA AC T T G A AGC T GAT G A A AT T AGC A AG AG A AT C A A

GGCCTTTAGTCCCACAATTCCCTCATTTTGAAAATCATATCAAGACTTCTGTT

GAT GA AGGGGC A A A A ATT GAC CGAGGT AT A AGATTC CTC CAT GAT C AGAT A A

TGAGTGTGAAAACAGTGGATCTCACACTGGTGATTTATGGATCGTTCAGACAT

TGGGGTCATCCTTTTATAGATTATTACACTGGACTAGAAAAATTACATTCCCA

AGT A AC CAT G A AG A A AG AT ATT GAT GT GT CAT AT GC A A A AGC AC TT GC A AGT

GATTTAGCTCGGATTGTTCTATTTCAACAGTTCAATGATCATAAAAAGTGGTT

CGTGAATGGAGACTTGCTCCCTCATGATCATCCCTTTAAAAGTCATGTTAAAG

AAAAT AC AT GGCCC AC AGCTGCTC A AGTT C AAGATTTTGGAGAT AA ATGGC A

TGAACTTCCGCTGATTAAATGTTTTGAAATACCCGACTTACTAGACCCATCGA

T A AT AT ACTCTGAC A A A AGTC ATT C A AT GA AT AGGT C AGAGGT GTT GA A AC A

TGTCCGAATGAATCCGAACACTCCTATCCCTAGTAAAAAGGTGTTGCAGACT

AT GTT GGAC AC AAAGGCT ACC AATTGGAAAGAATTTCTT AAAGAGATT GATG

AGAAGGGCTTAGATGATGATGATCTAATTATTGGTCTTAAAGGAAAGGAGAG

GGAACTGAAGTT GGC AGGT AGATTTTTCTCCCT AAT GTCTT GGAAATTGCGAG

AATACTTTGTAATTACCGAATATTTGATAAAGACTCATTTCGTCCCTATGTTTA

AAGGCCTGACAATGGCGGACGATCTAACTGCAGTCATTAAAAAGATGTTAGA

TTCCTCATCCGGCCAAGGATTGAAGTCATATGAGGCAATTTGCATAGCCAATC

AC ATTGATT ACGA A A A AT GGA AT A AC C AC C A A AGGA AGTT AT C A A AC GGCCC

AGTGTTCCGAGTTATGGGCCAGTTCTTAGGTTATCCATCCTTAATCGAGAGAA

CTCATGAATTTTTTGAGAAAAGTCTTATATACTACAATGGAAGACCAGACTTG

ATGCGTGTTCACAACAACACACTGATCAATTCAACCTCCCAACGAGTTTGTTG

GC A AGGAC A AGAGGGT GGAC T GGA AGGTCT ACGGC A A A A AGGAT GGACT AT

CCTCAATCTACTGGTTATTCAAAGAGAGGCTAAAATCAGAAACACTGCTGTC

AAAGTCTTGGC AC AAGGTGAT AAT C AAGTT ATTT GC AC AC AGT AT AAAACGA

AGAAATCGAGAAACGTTGT AGAATT AC AGGGT GCTCTC AAT C AAAT GGTTT C

T AAT AAT GAG A A A ATT AT GAC T GC AAT C A A A AT AGGG AC AGGG A AGT T AGGA CTTTTGATAAATGACGATGAGACTATGCAATCTGCAGATTACTTGAATTATGG

AAAAATACCGATTTTCCGTGGAGTGATTAGAGGGTTAGAGACCAAGAGATGG

TCACGAGTGACTTGTGTCACCAATGACCAAATACCCACTTGTGCTAATATAAT

GAGCTCAGTTTCCACAAATGCTCTCACCGTAGCTCATTTTGCTGAGAACCCAA

TCAATGCCATGATACAGTACAATTATTTTGGGACATTTGCTAGACTCTTGTTG

ATGATGCATGATCCTGCTCTTCGTCAATCATTGTATGAAGTTCAAGATAAGAT

ACCGGGCTTGCACAGTTCTACTTTCAAATACGCCATGTTGTATTTGGACCCTT

CCATTGGAGGAGTGTCGGGCATGTCTTTGTCCAGGTTTTTGATTAGAGCCTTC

CCAGATCCCGTAACAGAAAGTCTCTCATTCTGGAGATTCATCCATGTACATGC

TCGAAGTGAGCATCTGAAGGAGATGAGTGCAGTATTTGGAAACCCCGAGATA

GCCAAGTTTCGAATAACTCACATAGACAAGCTAGTAGAAGATCCAACCTCTC

TGAACATCGCTATGGGAATGAGTCCAGCGAACTTGTTAAAGACTGAGGTTAA

AAAATGCTTAATCGAATCAAGACAAACCATCAGGAACCAGGTGATTAAGGAT

GCAACCATATATTTGTATCATGAAGAGGATCGGCTCAGAAGTTTCTTATGGTC

AATAAATCCTCTGTTCCCTAGATTTTTAAGTGAATTCAAATCAGGCACTTTTTT

GGGAGTCGCAGACGGGCTCATCAGTCTATTTCAAAATTCTCGTACTATTCGGA

ACTCCTTTAAGAAAAAGTATCATAGGGAATTGGATGATTTGATTGTGAGGAG

TGAGGTATCCTCTTTGACACATTTAGGGAAACTTCATTTGAGAAGGGGATCAT

GT AAAAT GTGGAC ATGTTC AGCT ACTC AT GCTGAC AC ATT AAGAT AC AAAT C

CTGGGGCCGTACAGTTATTGGGACAACTGTACCCCATCCATTAGAAATGTTGG

GTCC AC AAC ATCGAAAAGAGACTCCTT GT GC ACC AT GT AAC AC AT C AGGGTT

CAATTATGTTTCTGTGCATTGTCCAGACGGGATCCATGACGTCTTTAGTTCAC

GGGGACCATTGCCTGCTTATCTAGGGTCTAAAACATCTGAATCTACATCTATT

TTGCAGCCTTGGGAAAGGGAAAGCAAAGTCCCACTGATTAAAAGAGCTACAC

GTCTTAGAGATGCTATCTCTTGGTTTGTTGAACCCGACTCTAAACTAGCAATG

ACTATACTTTCTAACATCCACTCTTTAACAGGCGAAGAATGGACCAAAAGGC

AGCATGGGTTCAAAAGAACAGGGTCTGCCCTTCATAGGTTTTCGACATCTCGG

ATGAGCCATGGTGGGTTCGCATCTCAGAGCACTGCAGCATTGACCAGGTTGA

TGGCAACTACAGACACCATGAGGGATCTGGGAGATCAGAATTTCGACTTTTT

ATTCCAAGCAACGTTGCTCTATGCTCAAATTACCACCACTGTTGCAAGAGACG

GATGGATCACCAGTTGTACAGATCATTATCATATTGCCTGTAAGTCCTGTTTG

AGACCCATAGAAGAGATCACCCTGGACTCAAGTATGGACTACACGCCCCCAG

AT GT AT C C C AT GT GC T G A AG AC AT GG AGG A AT GGGG A AGGT T C GT GGGG AC A

AGAGATAAAACAGATCTATCCTTTAGAAGGGAATTGGAAGAATTTAGCACCT GCTGAGCAATCCTATCAAGTCGGCAGATGTATAGGTTTTCTATATGGAGACTT

GGCGTATAGAAAATCTACTCATGCCGAGGACAGTTCTCTATTTCCTCTATCTA

T AC AAGGTCGT ATT AGAGGTCGAGGTTTCTT AAAAGGGTT GCT AGACGGATT

AATGAGAGCAAGTTGCTGCCAAGTAATACACCGGAGAAGTCTGGCTCATTTG

AAGAGGCCGGCC AACGC AGT GT ACGGAGGTTTGATTT ACTTGATT GAT AAAT

TGAGTGTATCACCTCCATTCCTTTCTCTTACTAGATCAGGACCTATTAGAGAC

GAATTAGAAACGATTCCCCACAAGATCCCAACCTCCTATCCGACAAGCAACC

GTGATATGGGGGTGATTGTCAGAAATTACTTCAAATACCAATGCCGTCTAATT

GAAAAGGGAAAATACAGATCACATTATTCACAATTATGGTTATTCTCAGATGT

CTTATCCATAGACTTCATTGGACCATTCTCTATTTCCACCACCCTCTTGCAAAT

CCT AT AC AAGCC ATTTTT ATCTGGGAAAGAT AAGAAT GAGTTGAGAGAGCTG

GCA A AT C TTTC TT C ATTGC T A AGAT C AGGAGAGGGGT GGGA AGAC AT AC AT G

TGAAATTCTTCACCAAGGACATATTATTGTGTCCAGAGGAAATCAGACATGCT

TGCAAGTTCGGGATTGCTAAGGATAATAATAAAGACATGAGCTATCCCCCTT

GGGGA AGGGA AT C C AGAGGGAC A ATT AC A AC A AT C CC T GTTT ATT AT AC GAC

CACCCCTTACCCAAAGATGCTAGAGATGCCTCCAAGAATCCAAAATCCCCTG

CTGTCCGGAATCAGGTTGGGCCAATTACCAACTGGCGCTCATTATAAAATTCG

GAGTATATTACATGGAATGGGAATCCATTACAGGGACTTCTTGAGTTGTGGA

GACGGCTCCGGAGGGATGACTGCTGCATTACTACGAGAAAATGTGCATAGCA

G AGG A AT AT TC A AT AGT C T GT T AG A ATT AT C AGGGT C AGT CAT GC G AGGC GC

CTCTCCTGAGCCCCCCAGTGCCCTAGAAACTTTAGGAGGAGATAAATCGAGA

TGTGTAAATGGTGAAACATGTTGGGAATATCCATCTGACTTATGTGACCCAAG

GACTTGGGACTATTTCCTCCGACTCAAAGCAGGCTTGGGGCTTCAAATTGATT

TAATTGTAATGGATATGGAAGTTCGGGATTCTTCTACTAGCCTGAAAATTGAG

ACGAATGTTAGAAATTATGTGCACCGGATTTTGGATGAGCAAGGAGTTTTAAT

CT AC AAGACTT AT GGAAC AT AT ATTTGT GAGAGCGAAAAGAAT GC AGT AAC A

ATCCTTGGTCCCATGTTCAAGACGGTCGACTTAGTTCAAACAGAATTTAGTAG

T TC T C A A AC GT C T G A AGT AT AT AT GGT AT GT A A AGGT TT G A AG A A ATT A AT C G

ATGAACCCAATCCCGATTGGTCTTCCATCAATGAATCCTGGAAAAACCTGTAC

GC ATTCC AGT CAT C AGAAC AGGAATTT GCC AGAGC AAAGAAGGTT AGT AC AT

ACTTTACCTTGACAGGTATTCCCTCCCAATTCATTCCTGATCCTTTTGTAAACA

TTGAGACTATGCTACAAATATTCGGAGTACCCACGGGTGTGTCTCATGCGGCT

GCCTTAAAATCATCTGATAGACCTGCAGATTTATTGACCATTAGCCTTTTTTAT

ATGGCGATTATATCGTATTATAACATCAATCATATCAGAGTAGGACCGATACC TCCGAACCCCCCATCAGATGGAATTGCACAAAATGTGGGGATCGCTATAACT

GGTATAAGCTTTTGGCTGAGTTTGATGGAGAAAGACATTCCACTATATCAACA

GTGTTTAGCAGTTATCCAGCAATCATTCCCGATTAGGTGGGAGGCTGTTTCAG

T A A A AGGAGGAT AC A AGC AG A AGT GGAGT AC T AGAGGT GAT GGGCTCC C A A

AAGATACCCGAACTTCAGACTCCTTGGCCCCAATCGGGAACTGGATCAGATC

TCTGGAATTGGTCCGAAACCAAGTTCGTCTAAATCCATTCAATGAGATCTTGT

TCAATCAGCTATGTCGTACAGTGGATAATCATTTGAAATGGTCAAATTTGCGA

AG A A AC AC AGG A AT GAT T G A AT GG AT C A AT AG AC G A AT TT C A A A AG A AG AC

C GGT C T AT AC T GAT GTT G A AG AGT G AC C T AC AC G AGG A A A AC TC TT GG AG AG

ATT AAAAAATC AT GAGGAGACTCC AAACTTT AAGT ATGAA AAAAACTTT GAT

CCTTAAGACCCTCTTGTGGTTTTTATTTTTTATCTGGTTTTGTGGTCTTCGT.

In some embodiments, the nucleic acid comprises the sequence of SEQ ID NO:

24, shown below (VSV vector: Convac V4 China):

ACGAAGAC AAAC AAACC ATT ATT AT C ATT AAAAGGCTCAGGAG AAACTTT AA

C AGT AAT C AAA ATGTCTGTT AC AGTC AAGAGAAT C ATTGAC AAC AC AGTC AT

AGTTCCAAAACTTCCTGCAAATGAGGATCCAGTGGAATACCCGGCAGATTAC

TTCAGAAAATCAAAGGAGATTCCTCTTTACATCAATACTACAAAAAGTTTGTC

AGATCTAAGAGGATATGTCTACCAAGGCCTCAAATCCGGAAATGTATCAATC

AT AC AT GT C A AC AGC T AC TT GT AT GG AGC ATT A A AGG AC ATC C GGGGT AAGT

T GG AT A A AG AT T GGT C A AGTT T C GG A AT AAAC ATC GGG A A AGC AGGGG AT AC

AATCGGAATATTTGACCTTGTATCCTTGAAAGCCCTGGACGGCGTACTTCCAG

AT GGAGT ATCGG AT GCTTCC AGAACC AGCGC AGAT GAC AAAT GGTT GCCTTT

GTATCTACTTGGCTTATACAGAGTGGGCAGAACACAAATGCCTGAATACAGA

A A A A AGC TC AT GGAT GGGC T GAC A A AT C A AT GCA A A AT GAT C A AT GA AC AGT

TTGAACCTCTTGTGCCAGAAGGTCGTGACATTTTTGATGTGTGGGGAAATGAC

AGTAATTACACAAAAATTGTCGCTGCAGTGGACATGTTCTTCCACATGTTCAA

AAAACATGAATGTGCCTCGTTCAGATACGGAACTATTGTTTCCAGATTCAAAG

ATTGTGCTGCATTGGCAACATTTGGACACCTCTGCAAAATAACCGGAATGTCT

ACAGAAGATGTAACGACCTGGATCTTGAACCGAGAAGTTGCAGATGAAATGG

TCCAAATGATGCTTCCAGGCCAAGAAATTGACAAGGCCGATTCATACATGCC

TTATTTGATCGACTTTGGATTGTCTTCTAAGTCTCCATATTCTTCCGTCAAAAA

CCCTGCCTTCCACTTCTGGGGGCAATTGACAGCTCTTCTGCTCAGATCCACCA

GAGCAAGGAATGCCCGACAGCCTGATGACATTGAGTATACATCTCTTACTAC

AGCAGGTTTGTTGTACGCTTATGCAGTAGGATCCTCTGCCGACTTGGCACAAC AGTTTTGTGTTGGAGATAACAAATACACTCCAGATGATAGTACCGGAGGATT

GACGACTAATGCACCGCCACAAGGCAGAGATGTGGTCGAATGGCTCGGATGG

T TT G A AG AT C A A A AC AG A A A AC C G AC TC C T GAT AT GAT GC AGT AT GC G A A A A

GAGCAGTCATGTCACTGCAAGGCCTAAGAGAGAAGACAATTGGCAAGTATGC

TAAGTCAGAATTTGACAAATGACCCTATAATTCTCAGATCACCTATTATATAT

TATGCTACATATGAAAAAAACTAACAGATATCATGGATAATCTCACAAAAGT

TCGTGAGTATCTCAAGTCCTATTCTCGTCTGGATCAGGCGGTAGGAGAGATAG

ATGAGATCGAAGCACAACGAGCTGAAAAGTCCAATTATGAGTTGTTCCAAGA

GGATGGAGTGGAAGAGCATACTAAGCCCTCTTATTTTCAGGCAGCAGATGAT

TCTGAC AC AGA AT C T GA AC C AG A A ATT GA AG AC A AT C A AGGTTT GT AT GC AC

CAGATCCAGAAGCTGAGCAAGTTGAAGGCTTTATACAGGGGCCTTTAGATGA

CT AT GC AGAT GAGGAAGT GGAT GTT GT ATTT ACTTCGGACTGGAAAC AGCCT

GAGCTTGAATCTGACGAGCATGGAAAGACCTTACGGTTGACATCGCCAGAGG

GTTTAAGTGGAGAGCAGAAATCCCAGTGGCTTTCGACGATTAAAGCAGTCGT

GC AAAGTGCC AAAT ACTGGAATCTGGC AGAGT GC AC ATTTGAAGC ATCGGGA

G A AGGGGT C AT T AT G A AGG AGC GC C AG AT A AC T C C GGAT GT AT AT A AGGT C A

CTCCAGTGATGAACACACATCCGTCCCAATCAGAAGCAGTATCAGATGTTTG

GTCTCTCTCAAAGACATCCATGACTTTCCAACCCAAGAAAGCAAGTCTTCAGC

CTCTCACCATATCCTTGGATGAATTGTTCTCATCTAGAGGAGAGTTCATCTCT

GTCGGAGGTGACGGACGAATGTCTCATAAAGAGGCCATCCTGCTCGGCCTGA

GATACAAAAAGTTGTACAATCAGGCGAGAGTCAAATATTCTCTGTAGACTAT

GAAAAAAAGTAACAGATATCACGATCTAAGTGTTATCCCAATCCATTCATCA

T G AGTT C C TT A A AG A AG AT TC TC GGT C T G A AGGGG A A AGGT A AG A A AT C T A A

GAAATTAGGGATCGCACCACCCCCTTATGAAGAGGACACTAGCATGGAGTAT

GCTCCGAGCGCTCCAATTGACAAATCCTATTTTGGAGTTGACGAGATGGACA

CCTATGATCCGAATCAATTAAGATATGAGAAATTCTTCTTTACAGTGAAAATG

ACGGTTAGATCTAATCGTCCGTTCAGAACATACTCAGATGTGGCAGCCGCTGT

ATCCCATTGGGATCACATGTACATCGGAATGGCAGGGAAACGTCCCTTCTAC

AAAATCTTGGCTTTTTTGGGTTCTTCTAATCTAAAGGCCACTCCAGCGGTATT

GGCAGATCAAGGTCAACCAGAGTATCACACTCACTGCGAAGGCAGGGCTTAT

TTGCCACATAGGATGGGGAAGACCCCTCCCATGCTCAATGTACCAGAGCACT

T C AGAAGACC ATTC AAT AT AGGTCTTT AC AAGGGAACGATTGAGCTC AC A AT

GACCATCTACGATGATGAGTCACTGGAAGCAGCTCCTATGATCTGGGATCATT

TCAATTCTTCCAAATTTTCTGATTTCAGAGAGAAGGCCTTAATGTTTGGCCTG ATTGTCGAGAAAAAGGCATCTGGAGCGTGGGTCCTGGATTCTATCAGCCACT

TCAAATGAGCTAGTCTAACTTCTAGCTTCTGAACAATCCCCGGTTTACTCAGT

CTCTCCTAATTCCAGCCTCTCGAACAACTAATATCCTGTCTTTTCTATCCCTAT

GAAAAAAACTAACAGAGATCGATCTGTTTACGCGTGCCACCATGTTCGTGTTT

CTGGTGCTGCTGCCTCTGGTGAGCTCCCAGTGCGTGAACCTGACCACAAGGA

CCCAGCTGCCCCCTGCCTATACCAATTCCTTCACACGGGGCGTGTACTATCCC

GACAAGGTGTTCCGGAGCAGCGTGCTGCACTCCACACAGGATCTGTTTCTGCC

TTTCTTTTCTAACGTGACCTGGTTCCACGCCATCCACGTGAGCGGCACCAATG

GCACAAAGCGGTTCGACAATCCAGTGCTGCCCTTTAACGATGGCGTGTACTTC

GCCTCCACCGAGAAGTCTAACATCATCAGAGGCTGGATCTTTGGCACCACAC

T GGAC AGC A AGAC AC AGT C CC T GC T GAT C GT GA AC A AT GC C AC C A AC GT GGT

CATCAAGGTGTGCGAGTTCCAGTTTTGTAATGATCCATTCCTGGGCGTGTACT

ATCACAAGAACAATAAGTCTTGGATGGAGAGCGAGTTTCGCGTGTATTCCTCT

GCCAACAATTGCACATTTGAGTACGTGTCCCAGCCCTTCCTGATGGACCTGGA

GGGC AAGC AGGGC AATTT C AAGAACCTGAGGGAGTTCGT GTTT AAGAAT ATC

GATGGCTACTTCAAAATCTACTCCAAGCACACCCCAATCAACCTGGTGCGCG

ACCTGCCACAGGGCTTCTCTGCCCTGGAGCCACTGGTGGATCTGCCCATCGGC

ATCAACATCACCCGGTTTCAGACACTGCTGGCCCTGCACAGAAGCTACCTGA

CACCAGGCGACAGCTCCTCTGGATGGACCGCAGGAGCAGCAGCCTACTATGT

GGGCTATCTGCAGCCCAGGACCTTCCTGCTGAAGTACAACGAGAATGGCACC

ATCACAGACGCCGTGGATTGCGCCCTGGATCCCCTGTCTGAGACCAAGTGTA

CACTGAAGAGCTTTACCGTGGAGAAGGGCATCTATCAGACAAGCAATTTCAG

GGTGCAGCCTACCGAGTCCATCGTGCGCTTTCCCAATATCACAAACCTGTGCC

CTTTTGGCGAGGTGTTCAACGCAACCCGCTTCGCCAGCGTGTACGCCTGGAAT

AGGAAGCGCATCTCCAACTGCGTGGCCGACTATTCTGTGCTGTACAACAGCG

CCTCCTTCTCTACCTTTAAGTGCTATGGCGTGAGCCCCACAAAGCTGAATGAC

CTGTGCTTTACCAACGTGTACGCCGATTCCTTCGTGATCAGGGGCGACGAGGT

GCGCCAGATCGCACCAGGACAGACAGGCAAGATCGCAGACTACAATTATAA

GCTGCCTGACGATTTCACCGGCTGCGTGATCGCCTGGAACTCTAACAATCTGG

ATAGCAAAGTGGGCGGCAACTACAATTATCTGTACCGGCTGTTTAGAAAGTC

TAATCTGAAGCCATTCGAGAGGGACATCTCCACAGAAATCTACCAGGCCGGC

TCTACCCCCTGCAATGGCGTGGAGGGCTTTAACTGTTATTTCCCTCTGCAGAG

CTACGGCTTCCAGCCAACAAACGGCGTGGGCTATCAGCCCTACCGCGTGGTG

GTGCTGTCTTTTGAGCTGCTGCACGCACCTGCAACAGTGTGCGGACCAAAGA AGAGCACCAATCTGGTGAAGAACAAGTGCGTGAACTTCAACTTCAACGGACT

GACCGGAACAGGCGTGCTGACCGAGTCCAACAAGAAGTTCCTGCCTTTTCAG

CAGTTCGGCAGGGACATCGCAGATACCACAGACGCCGTGCGCGACCCTCAGA

CCCTGGAGATCCTGGACATCACACCATGCTCCTTCGGCGGCGTGTCTGTGATC

ACACCAGGCACCAATACAAGCAACCAGGTGGCCGTGCTGTATCAGGACGTGA

ATTGTACCGAGGTGCCAGTGGCAATCCACGCAGATCAGCTGACCCCTACATG

GCGGGTGTACTCTACCGGCAGCAACGTGTTCCAGACAAGAGCCGGATGCCTG

ATCGGAGCAGAGCACGTGAACAATAGCTATGAGTGCGACATCCCTATCGGCG

CCGGCATCTGTGCCTCCTACCAGACCCAGACAAACTCCCCAAGGTCTGTGGG

CGATACAGGCCTGTCCAAGAATCCAATCGAGCTGGTAGAGGGCTGGTTCAGC

AGTTGGAAAAGCTCCATCGCCTCCTTTTTCTTTATCATCGGCCTGATCATCGG

ACTGTTCCTGGTGCTCCGCGTGGGTATCCACCTGTGCATCAAGCTGAAGCACA

CCAAGAAAAGACAGATTTATACAGACATCGAGATGAACCGCCTGGGAAAGgg atccggctccggcgagggcaggggaagtctactaacatgcggggacgtggaggaaaatcccggccccATGAAGTGC

CTTTTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTT

TTTCCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTA

TTGCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCA

TACAAGTCAAAATGCCCAAGAGTCACAAGGCTATTCAAGCAGACGGTTGGAT

GTGTCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGA

AGTATATAACACAGTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAG

GAAAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTC

CTC A A AGTT GT GGAT AT GCA AC T GT GAC GGAT GC CGA AGC AGT GATT GT CCA

GGT GACTCCTC AC CAT GT GC T GGTT GAT GA AT AC AC AGGAGA AT GGGTTGAT

TCACAGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATA

ACTCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAAC

CTCATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCT

GGGAAAGGAGGGCACAGGGTTCAGAAGTAACTACTTTGCTTATGAAACTGGA

GGC AAGGCCTGC AAAAT GC AAT ACTGC AAGC ATT GGGGAGT C AGACTCCC AT

CAGGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTC

CCTGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGA

TGTAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAG

AAACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAG

CTATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATG

GTACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCA AT C C T C T C A AG A AT GGT C GG A AT GAT C AGT GG A AC T AC C AC AG A A AGGG A AC

T GT GGGAT GAC T GGGC ACC AT AT GA AGACGT GGA A ATT GGACC C A AT GGAGT

TCTGAGGACC AGTT C AGGAT AT AAGTTTCCTTT AT AC AT GATTGGAC AT GGT A

TGTTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCT

CACATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGG

TGATACTGGGCTATCCAAAAATCCAATCGAGCTTGTAGAAGGTTGGTTCAGT

AGTTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGA

CTATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACC

AAGAAAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAAg

CTAGCCAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAA

GAGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAACTAACAGCAA

T CAT GGAAGTCC ACGATTTTGAGACCGACGAGTT C A ATGATTT C AAT GAAGA

TGACTATGCCACAAGAGAATTCCTGAATCCCGATGAGCGCATGACGTACTTG

AATCATGCTGATTACAATTTGAATTCTCCTCTAATTAGTGATGATATTGACAA

TTTGATCAGGAAATTCAATTCTCTTCCGATTCCCTCGATGTGGGATAGTAAGA

ACTGGGATGGAGTTCTTGAGATGTTAACATCATGTCAAGCCAATCCCATCTCA

ACATCTCAGATGCATAAATGGATGGGAAGTTGGTTAATGTCTGATAATCATG

AT GCC AGTC AAGGGT AT AGTTTTTT AC ATGAAGT GGAC AA AGAGGC AGAAAT

AACATTTGACGTGGTGGAGACCTTCATCCGCGGCTGGGGCAACAAACCAATT

GAATACATCAAAAAGGAAAGATGGACTGACTCATTCAAAATTCTCGCTTATT

TGTGTCAAAAGTTTTTGGACTTACACAAGTTGACATTAATCTTAAATGCTGTC

TCTGAGGTGGAATTGCTCAACTTGGCGAGGACTTTCAAAGGCAAAGTCAGAA

GAAGTTCTCATGGAACGAACATATGCAGGATTAGGGTTCCCAGCTTGGGTCC

TACTTTTATTTCAGAAGGATGGGCTTACTTCAAGAAACTTGATATTCTAATGG

ACC GA A AC TTTC T GTT A AT GGT C A A AGAT GT GATT AT AGGG AGGAT GCA A AC

GGTGCTATCCATGGTATGTAGAATAGACAACCTGTTCTCAGAGCAAGACATC

TTCTCCCTTCT AAAT ATCT AC AGAATT GGAGAT AAAATTGT GG AGAGGC AGG

GAAATTTTTCTTATGACTTGATTAAAATGGTGGAACCGATATGCAACTTGAAG

CTGATGAAATTAGCAAGAGAATCAAGGCCTTTAGTCCCACAATTCCCTCATTT

TGAAAATCATATCAAGACTTCTGTTGATGAAGGGGCAAAAATTGACCGAGGT

AT A AG AT TCCTCCAT GAT C AGAT AAT G AGT GT G A A A AC AGT GG AT C T C AC AC

TGGTGATTTATGGATCGTTCAGACATTGGGGTCATCCTTTTATAGATTATTAC

ACTGGACTAGAAAAATTACATTCCCAAGTAACCATGAAGAAAGATATTGATG

TGTCATATGCAAAAGCACTTGCAAGTGATTTAGCTCGGATTGTTCTATTTCAA CAGTTCAATGATCATAAAAAGTGGTTCGTGAATGGAGACTTGCTCCCTCATGA

TCATCCCTTTAAAAGTCATGTTAAAGAAAATACATGGCCCACAGCTGCTCAA

GTTCAAGATTTTGGAGATAAATGGCATGAACTTCCGCTGATTAAATGTTTTGA

AATACCCGACTTACTAGACCCATCGATAATATACTCTGACAAAAGTCATTCAA

TGAATAGGTCAGAGGTGTTGAAACATGTCCGAATGAATCCGAACACTCCTAT

CCCTAGTAAAAAGGTGTTGCAGACTATGTTGGACACAAAGGCTACCAATTGG

AAAGAATTTCTTAAAGAGATTGATGAGAAGGGCTTAGATGATGATGATCTAA

TTATTGGTCTTAAAGGAAAGGAGAGGGAACTGAAGTTGGCAGGTAGATTTTT

CTCCCTAATGTCTTGGAAATTGCGAGAATACTTTGTAATTACCGAATATTTGA

TAAAGACTCATTTCGTCCCTATGTTTAAAGGCCTGACAATGGCGGACGATCTA

ACTGC AGTC ATT AAAAAGAT GTT AGATTCCTC ATCCGGCC AAGGATT GAAGT

CATATGAGGCAATTTGCATAGCCAATCACATTGATTACGAAAAATGGAATAA

CCACCAAAGGAAGTTATCAAACGGCCCAGTGTTCCGAGTTATGGGCCAGTTC

TTAGGTTATCCATCCTTAATCGAGAGAACTCATGAATTTTTTGAGAAAAGTCT

T AT AT ACT AC AAT GGAAGACC AGACTT GAT GCGT GTT C AC A AC AAC AC ACTG

AT C AATTC AACCTCCC AACGAGTTTGTT GGC AAGGAC AAGAGGGT GGACTGG

AAGGTCTACGGCAAAAAGGATGGACTATCCTCAATCTACTGGTTATTCAAAG

AGAGGCT A A A AT C AGA A AC AC T GC T GTC A A AGT C TT GGC AC A AGGT GAT AAT

C A AGTT ATTTGC AC AC AGT AT A A A ACG A AGA A ATCGAGA A AC GTT GT AG A AT

T AC AGGGT GCTCTC A AT C A A AT GGTTTCT A AT AAT GAGA A A ATT AT GAC T GCA

ATCAAAATAGGGACAGGGAAGTTAGGACTTTTGATAAATGACGATGAGACTA

TGCAATCTGCAGATTACTTGAATTATGGAAAAATACCGATTTTCCGTGGAGTG

ATTAGAGGGTTAGAGACCAAGAGATGGTCACGAGTGACTTGTGTCACCAATG

ACCAAATACCCACTTGTGCTAATATAATGAGCTCAGTTTCCACAAATGCTCTC

ACCGTAGCTCATTTTGCTGAGAACCCAATCAATGCCATGATACAGTACAATTA

TTTTGGGACATTTGCTAGACTCTTGTTGATGATGCATGATCCTGCTCTTCGTCA

AT C ATTGT ATGA AGTT C AAGAT AAGAT ACCGGGCTTGC AC AGTTCT ACTTTC A

AATACGCCATGTTGTATTTGGACCCTTCCATTGGAGGAGTGTCGGGCATGTCT

TTGTCCAGGTTTTTGATTAGAGCCTTCCCAGATCCCGTAACAGAAAGTCTCTC

ATTCTGGAGATTC ATCC AT GT AC AT GCTCGAAGT GAGC ATCTGAAGGAGAT G

AGTGCAGTATTTGGAAACCCCGAGATAGCCAAGTTTCGAATAACTCACATAG

AC AAGCT AGT AGAAGATCC AACCTCTCTGAAC ATCGCT ATGGGAAT GAGTCC

AGCGAACTTGTT AAAGACTGAGGTT AAAAAAT GCTT AATCGAAT C AAGAC AA

ACCATCAGGAACCAGGTGATTAAGGATGCAACCATATATTTGTATCATGAAG AGGATCGGCTCAGAAGTTTCTTATGGTCAATAAATCCTCTGTTCCCTAGATTT

TTAAGTGAATTCAAATCAGGCACTTTTTTGGGAGTCGCAGACGGGCTCATCAG

TCTATTTCAAAATTCTCGTACTATTCGGAACTCCTTTAAGAAAAAGTATCATA

GGGAATTGGATGATTTGATTGTGAGGAGTGAGGTATCCTCTTTGACACATTTA

GGGAAACTTCATTTGAGAAGGGGATCATGTAAAATGTGGACATGTTCAGCTA

CTCATGCTGACACATTAAGATACAAATCCTGGGGCCGTACAGTTATTGGGAC

AACTGT ACCCC ATCC ATT AGAAAT GTT GGGTCC AC AAC ATCGAAAAGAGACT

CCTTGTGCACCATGTAACACATCAGGGTTCAATTATGTTTCTGTGCATTGTCC

AGACGGGATCCATGACGTCTTTAGTTCACGGGGACCATTGCCTGCTTATCTAG

GGTCTAAAACATCTGAATCTACATCTATTTTGCAGCCTTGGGAAAGGGAAAG

CAAAGTCCCACTGATTAAAAGAGCTACACGTCTTAGAGATGCTATCTCTTGGT

TTGTTGAACCCGACTCTAAACTAGCAATGACTATACTTTCTAACATCCACTCT

TTAACAGGCGAAGAATGGACCAAAAGGCAGCATGGGTTCAAAAGAACAGGG

TCTGCCCTTCATAGGTTTTCGACATCTCGGATGAGCCATGGTGGGTTCGCATC

T C AGAGC ACTGC AGC ATTGACC AGGTT GAT GGC AACT AC AGAC ACC AT GAGG

GATCTGGGAGATCAGAATTTCGACTTTTTATTCCAAGCAACGTTGCTCTATGC

TCAAATTACCACCACTGTTGCAAGAGACGGATGGATCACCAGTTGTACAGAT

CATTATCATATTGCCTGTAAGTCCTGTTTGAGACCCATAGAAGAGATCACCCT

GGACTCAAGTATGGACTACACGCCCCCAGATGTATCCCATGTGCTGAAGACA

TGGAGGAATGGGGAAGGTTCGTGGGGACAAGAGATAAAACAGATCTATCCTT

T AGAAGGGAATTGGAAGA ATTT AGC ACCTGCTGAGC AATCCT AT C AAGTCGG

CAGATGTATAGGTTTTCTATATGGAGACTTGGCGTATAGAAAATCTACTCATG

CCGAGGACAGTTCTCTATTTCCTCTATCTATACAAGGTCGTATTAGAGGTCGA

GGTTTCTT A AAAGGGTT GCT AGAC GG ATT AAT GAGAGC AAGTT GCTGCC AAG

TAATACACCGGAGAAGTCTGGCTCATTTGAAGAGGCCGGCCAACGCAGTGTA

CGGAGGTTTGATTTACTTGATTGATAAATTGAGTGTATCACCTCCATTCCTTTC

TCTTACTAGATCAGGACCTATTAGAGACGAATTAGAAACGATTCCCCACAAG

ATCCCAACCTCCTATCCGACAAGCAACCGTGATATGGGGGTGATTGTCAGAA

ATTACTTCAAATACCAATGCCGTCTAATTGAAAAGGGAAAATACAGATCACA

TTATTCACAATTATGGTTATTCTCAGATGTCTTATCCATAGACTTCATTGGACC

ATTCTCTATTTCCACCACCCTCTTGCAAATCCTATACAAGCCATTTTTATCTGG

GAAAGATAAGAATGAGTTGAGAGAGCTGGCAAATCTTTCTTCATTGCTAAGA

TCAGGAGAGGGGTGGGAAGACATACATGTGAAATTCTTCACCAAGGACATAT

T ATT GTGTCC AGAGGAAAT C AGAC AT GCTTGC AAGTTCGGGATT GCT AAGGA TAATAATAAAGACATGAGCTATCCCCCTTGGGGAAGGGAATCCAGAGGGACA

ATTACAACAATCCCTGTTTATTATACGACCACCCCTTACCCAAAGATGCTAGA

GATGCCTCCAAGAATCCAAAATCCCCTGCTGTCCGGAATCAGGTTGGGCCAA

TTACCAACTGGCGCTCATTATAAAATTCGGAGTATATTACATGGAATGGGAAT

CCATTACAGGGACTTCTTGAGTTGTGGAGACGGCTCCGGAGGGATGACTGCT

GCATTACTACGAGAAAATGTGCATAGCAGAGGAATATTCAATAGTCTGTTAG

AATTATCAGGGTCAGTCATGCGAGGCGCCTCTCCTGAGCCCCCCAGTGCCCTA

GA A AC TTT AGGAGGAGAT A A ATCGAGAT GT GT A A AT GGT GA A AC AT GTT GGG

AATATCCATCTGACTTATGTGACCCAAGGACTTGGGACTATTTCCTCCGACTC

AAAGC AGGCTTGGGGCTTC AAATT GATTT AATT GT AAT GGAT AT GGAAGTTCG

GGATTCTTCTACTAGCCTGAAAATTGAGACGAATGTTAGAAATTATGTGCACC

GGATTTTGGAT GAGC A AGGAGTTTT A AT C T AC A AG AC TT AT GGA AC AT AT ATT

TGTGAGAGCGAAAAGAATGCAGTAACAATCCTTGGTCCCATGTTCAAGACGG

TCGACTTAGTTCAAACAGAATTTAGTAGTTCTCAAACGTCTGAAGTATATATG

GTATGTAAAGGTTTGAAGAAATTAATCGATGAACCCAATCCCGATTGGTCTTC

CAT C AAT GAATCCTGGAA AAACCTGT ACGC ATTCC AGT CAT C AGAAC AGGAA

TTT GCC AGAGC AAAGAAGGTT AGT AC AT ACTTT ACCTT GAC AGGT ATTCCCTC

CCAATTCATTCCTGATCCTTTTGTAAACATTGAGACTATGCTACAAATATTCG

GAGTACCCACGGGTGTGTCTCATGCGGCTGCCTTAAAATCATCTGATAGACCT

GCAGATTTATTGACCATTAGCCTTTTTTATATGGCGATTATATCGTATTATAAC

ATCAATCATATCAGAGTAGGACCGATACCTCCGAACCCCCCATCAGATGGAA

TTGCACAAAATGTGGGGATCGCTATAACTGGTATAAGCTTTTGGCTGAGTTTG

ATGGAGAAAGACATTCCACTATATCAACAGTGTTTAGCAGTTATCCAGCAAT

C ATTCCCGATT AGGT GGGAGGCTGTTTC AGT AAAAGGAGGAT AC AAGC AGAA

GTGGAGTACTAGAGGTGATGGGCTCCCAAAAGATACCCGAACTTCAGACTCC

TTGGCCCCAATCGGGAACTGGATCAGATCTCTGGAATTGGTCCGAAACCAAG

TTCGTCTAAATCCATTCAATGAGATCTTGTTCAATCAGCTATGTCGTACAGTG

GATAATCATTTGAAATGGTCAAATTTGCGAAGAAACACAGGAATGATTGAAT

GGATCAATAGACGAATTTCAAAAGAAGACCGGTCTATACTGATGTTGAAGAG

T GACCT AC AC GAGGA A A AC TC TT GGAGAGATT A A A A A AT CAT GAGGAGAC T C

CAAACTTTAAGTATGAAAAAAACTTTGATCCTTAAGACCCTCTTGTGGTTTTT

ATTTTTTATCTGGTTTTGTGGTCTTCGT.

In other embodiments, the nucleic acid comprises the sequence of SEQ ID NO:

25, shown below (VSV vector: Convac V4 South Africa): ACGAAGAC AAAC AAACC ATT ATT AT C ATT AAAAGGCTC AGGAGAAACTTT AA

C AGT AAT C AAA ATGTCTGTT AC AGTC AAGAGAAT C ATTGAC AAC AC AGTC AT

AGTTCCAAAACTTCCTGCAAATGAGGATCCAGTGGAATACCCGGCAGATTAC

TTCAGAAAATCAAAGGAGATTCCTCTTTACATCAATACTACAAAAAGTTTGTC

AGATCTAAGAGGATATGTCTACCAAGGCCTCAAATCCGGAAATGTATCAATC

AT AC AT GT C A AC AGC T AC TT GT AT GG AGC ATT A A AGG AC ATC C GGGGT A AGT

T GG AT A A AG AT T GGT C A AGTT T C GG A AT AAAC ATC GGG A A AGC AGGGG AT AC

AATCGGAATATTTGACCTTGTATCCTTGAAAGCCCTGGACGGCGTACTTCCAG

AT GGAGT ATCGGAT GCTTCC AGAACC AGCGC AGAT GAC AAAT GGTT GCCTTT

GTATCTACTTGGCTTATACAGAGTGGGCAGAACACAAATGCCTGAATACAGA

A A A A AGC TC AT GGAT GGGC T GAC A A AT C A AT GCA A A AT GAT C A AT GA AC AGT

TTGAACCTCTTGTGCCAGAAGGTCGTGACATTTTTGATGTGTGGGGAAATGAC

AGTAATTACACAAAAATTGTCGCTGCAGTGGACATGTTCTTCCACATGTTCAA

AAAACATGAATGTGCCTCGTTCAGATACGGAACTATTGTTTCCAGATTCAAAG

ATTGTGCTGCATTGGCAACATTTGGACACCTCTGCAAAATAACCGGAATGTCT

ACAGAAGATGTAACGACCTGGATCTTGAACCGAGAAGTTGCAGATGAAATGG

TCCAAATGATGCTTCCAGGCCAAGAAATTGACAAGGCCGATTCATACATGCC

TTATTTGATCGACTTTGGATTGTCTTCTAAGTCTCCATATTCTTCCGTCAAAAA

CCCTGCCTTCCACTTCTGGGGGCAATTGACAGCTCTTCTGCTCAGATCCACCA

GAGCAAGGAATGCCCGACAGCCTGATGACATTGAGTATACATCTCTTACTAC

AGCAGGTTTGTTGTACGCTTATGCAGTAGGATCCTCTGCCGACTTGGCACAAC

AGTTTTGTGTTGGAGATAACAAATACACTCCAGATGATAGTACCGGAGGATT

GACGACTAATGCACCGCCACAAGGCAGAGATGTGGTCGAATGGCTCGGATGG

T TT G A AG AT C A A A AC AG A A A AC C GAC TC C T GAT AT GAT GC AGT AT GC G A A A A

GAGCAGTCATGTCACTGCAAGGCCTAAGAGAGAAGACAATTGGCAAGTATGC

TAAGTCAGAATTTGACAAATGACCCTATAATTCTCAGATCACCTATTATATAT

TATGCTACATATGAAAAAAACTAACAGATATCATGGATAATCTCACAAAAGT

TCGTGAGTATCTCAAGTCCTATTCTCGTCTGGATCAGGCGGTAGGAGAGATAG

ATGAGATCGAAGCACAACGAGCTGAAAAGTCCAATTATGAGTTGTTCCAAGA

GGATGGAGTGGAAGAGCATACTAAGCCCTCTTATTTTCAGGCAGCAGATGAT

TCTGAC AC AGA AT C T GA AC C AG A A ATT GA AG AC A AT C A AGGTTT GT AT GC AC

CAGATCCAGAAGCTGAGCAAGTTGAAGGCTTTATACAGGGGCCTTTAGATGA

CT AT GC AGAT GAGGAAGT GGAT GTT GT ATTT ACTTCGGACTGGAAAC AGCCT

GAGCTTGAATCTGACGAGCATGGAAAGACCTTACGGTTGACATCGCCAGAGG GTTTAAGTGGAGAGCAGAAATCCCAGTGGCTTTCGACGATTAAAGCAGTCGT

GC AAAGTGCC AAAT ACTGGAATCTGGC AGAGT GC AC ATTTGAAGC ATCGGGA

G A AGGGGT C AT T AT G A AGG AGC GC C AG AT A AC T C C GG AT GT AT AT A AGGT C A

CTCCAGTGATGAACACACATCCGTCCCAATCAGAAGCAGTATCAGATGTTTG

GTCTCTCTCAAAGACATCCATGACTTTCCAACCCAAGAAAGCAAGTCTTCAGC

CTCTCACCATATCCTTGGATGAATTGTTCTCATCTAGAGGAGAGTTCATCTCT

GTCGGAGGTGACGGACGAATGTCTCATAAAGAGGCCATCCTGCTCGGCCTGA

GATACAAAAAGTTGTACAATCAGGCGAGAGTCAAATATTCTCTGTAGACTAT

GAAAAAAAGTAACAGATATCACGATCTAAGTGTTATCCCAATCCATTCATCA

T G AGTT C C TT A A AG A AG AT TC TC GGT C T G A AGGGG A A AGGT A AG A A AT C T A A

GAAATTAGGGATCGCACCACCCCCTTATGAAGAGGACACTAGCATGGAGTAT

GCTCCGAGCGCTCCAATTGACAAATCCTATTTTGGAGTTGACGAGATGGACA

CCTATGATCCGAATCAATTAAGATATGAGAAATTCTTCTTTACAGTGAAAATG

ACGGTTAGATCTAATCGTCCGTTCAGAACATACTCAGATGTGGCAGCCGCTGT

ATCCCATTGGGATCACATGTACATCGGAATGGCAGGGAAACGTCCCTTCTAC

AAAATCTTGGCTTTTTTGGGTTCTTCTAATCTAAAGGCCACTCCAGCGGTATT

GGCAGATCAAGGTCAACCAGAGTATCACACTCACTGCGAAGGCAGGGCTTAT

TTGCCACATAGGATGGGGAAGACCCCTCCCATGCTCAATGTACCAGAGCACT

T C AGAAGACC ATTC AAT AT AGGTCTTT AC AAGGGAACGATTGAGCTC AC A AT

GACCATCTACGATGATGAGTCACTGGAAGCAGCTCCTATGATCTGGGATCATT

TCAATTCTTCCAAATTTTCTGATTTCAGAGAGAAGGCCTTAATGTTTGGCCTG

ATTGTCGAGAAAAAGGCATCTGGAGCGTGGGTCCTGGATTCTATCAGCCACT

TCAAATGAGCTAGTCTAACTTCTAGCTTCTGAACAATCCCCGGTTTACTCAGT

CTCTCCTAATTCCAGCCTCTCGAACAACTAATATCCTGTCTTTTCTATCCCTAT

GAAAAAAACTAACAGAGATCGATCTGTTTACGCGTGCCACCATGTTCGTGTTT

CTGGTGCTGCTGCCTCTGGTGAGCTCCCAGTGCGTGAACTTCACCACAAGGAC

CCAGCTGCCCCCTGCCTATACCAATTCCTTCACACGGGGCGTGTACTATCCCG

ACAAGGTGTTCCGGAGCAGCGTGCTGCACTCCACACAGGATCTGTTTCTGCCT

TTCTTTTCTAACGTGACCTGGTTCCACGCCATCCACGTGAGCGGCACCAATGG

CACAAAGCGGTTCGCCAATCCAGTGCTGCCCTTTAACGATGGCGTGTACTTCG

CCTCCACCGAGAAGTCTAACATCATCAGAGGCTGGATCTTTGGCACCACACT

GGACAGCAAGACACAGTCCCTGCTGATCGTGAACAATGCCACCAACGTGGTC

ATCAAGGTGTGCGAGTTCCAGTTTTGTAATGATCCATTCCTGGGCGTGTACTA

TCACAAGAACAATAAGTCTTGGATGGAGAGCGAGTTTCGCGTGTATTCCTCTG CCAACAATTGCACATTTGAGTACGTGTCCCAGCCCTTCCTGATGGACCTGGAG

GGC AAGC AGGGC AATTT C AAGAACCTGAGGGAGTTCGT GTTT AAGAAT ATCG

ATGGCTACTTCAAAATCTACTCCAAGCACACCCCAATCAACCTGGTGCGCGG

CCTGCCACAGGGCTTCTCTGCCCTGGAGCCACTGGTGGATCTGCCCATCGGCA

TCAACATCACCCGGTTTCAGACACTGCTGGCCCTGCACAGAAGCTACCTGAC

ACCAGGCGACAGCTCCTCTGGATGGACCGCAGGAGCAGCAGCCTACTATGTG

GGCTATCTGCAGCCCAGGACCTTCCTGCTGAAGTACAACGAGAATGGCACCA

TCACAGACGCCGTGGATTGCGCCCTGGATCCCCTGTCTGAGACCAAGTGTAC

ACTGAAGAGCTTTACCGTGGAGAAGGGCATCTATCAGACAAGCAATTTCAGG

GTGCAGCCTACCGAGTCCATCGTGCGCTTTCCCAATATCACAAACCTGTGCCC

TTTTGGCGAGGTGTTCAACGCAACCCGCTTCGCCAGCGTGTACGCCTGGAATA

GGAAGCGCATCTCCAACTGCGTGGCCGACTATTCTGTGCTGTACAACAGCGC

CTCCTTCTCTACCTTTAAGTGCTATGGCGTGAGCCCCACAAAGCTGAATGACC

TGTGCTTTACCAACGTGTACGCCGATTCCTTCGTGATCAGGGGCGACGAGGTG

CGCCAGATCGCACCAGGACAGACAGGCAATATCGCAGACTACAATTATAAGC

TGCCTGACGATTTCACCGGCTGCGTGATCGCCTGGAACTCTAACAATCTGGAT

AGCAAAGTGGGCGGCAACTACAATTATCTGTACCGGCTGTTTAGAAAGTCTA

ATCTGAAGCCATTCGAGAGGGACATCTCCACAGAAATCTACCAGGCCGGCTC

TACCCCCTGCAATGGCGTGAAGGGCTTTAACTGTTATTTCCCTCTGCAGAGCT

ACGGCTTCCAGCCAACATATGGCGTGGGCTATCAGCCCTACCGCGTGGTGGT

GCTGTCTTTTGAGCTGCTGCACGCACCTGCAACAGTGTGCGGACCAAAGAAG

AGCACCAATCTGGTGAAGAACAAGTGCGTGAACTTCAACTTCAACGGACTGA

CCGGAACAGGCGTGCTGACCGAGTCCAACAAGAAGTTCCTGCCTTTTCAGCA

GTTCGGCAGGGACATCGCAGATACCACAGACGCCGTGCGCGACCCTCAGACC

CTGGAGATCCTGGACATCACACCATGCTCCTTCGGCGGCGTGTCTGTGATCAC

ACC AGGC ACC AAT AC AAGC AACC AGGT GGCCGTGCTGT AT C AGGGC GT GAAT

TGTACCGAGGTGCCAGTGGCAATCCACGCAGATCAGCTGACCCCTACATGGC

GGGTGTACTCTACCGGCAGCAACGTGTTCCAGACAAGAGCCGGATGCCTGAT

CGGAGCAGAGCACGTGAACAATAGCTATGAGTGCGACATCCCTATCGGCGCC

GGCATCTGTGCCTCCTACCAGACCCAGACAAACTCCCCAAGGTCTGTGGGCG

ATACAGGCCTGTCCAAGAATCCAATCGAGCTGGTAGAGGGCTGGTTCAGCAG

TTGGAAAAGCTCCATCGCCTCCTTTTTCTTTATCATCGGCCTGATCATCGGACT

GTTCCTGGTGCTCCGCGTGGGTATCCACCTGTGCATCAAGCTGAAGCACACCA

AGAAAAGACAGATTTATACAGACATCGAGATGAACCGCCTGGGAAAGggatccg gctccggcgagggcaggggaagtctactaacatgcggggacgtggaggaaaatcccggccccATGAAGTGCCTT

TTGTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTT

CCACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATT

GCCCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCAT

AC AAGTC AAAAT GCCC AAGAGT C AC AAGGCT ATT C A AGC AGACGGTT GGAT G

TGTCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAA

GTATATAACACAGTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGG

AAAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCC

TCAAAGTTGTGGATATGCAACTGTGACGGATGCCGAAGCAGTGATTGTCCAG

GTGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTC

ACAGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAAC

TCTACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCT

CATTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGG

GAAAGGAGGGC AC AGGGTTC AGAAGT AACT ACTTT GCTT ATGAAACTGGAGG

CAAGGCCTGCAAAATGCAATACTGCAAGCATTGGGGAGTCAGACTCCCATCA

GGTGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCC

TGAATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATG

TAAGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAA

ACCTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCT

ATCTTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGT

ACCCTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAAT

CCTCTCAAGAATGGTCGGAATGATCAGTGGAACTACCACAGAAAGGGAACTG

TGGGATGACTGGGCACCATATGAAGACGTGGAAATTGGACCCAATGGAGTTC

TGAGGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATG

TTGGACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCA

CATTCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTG

AT ACTGGGCT ATCC AAAAATCC AATCGAGCTTGT AGAAGGTTGGTT C AGT AG

TTGGAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACT

ATTCTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCA

AGAAAAGAC AGATTT AT AC AG AC AT AGAGATGAACCGACTT GGAAAGT AAgC

TAGCCAGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAG

AGGCCTCAATTATATTTGAGTTTTTAATTTTTATGAAAAAAACTAACAGCAAT

CAT GGAAGTCC ACGATTTTGAGACCGACGAGTTC AATGATTTC AAT GAAGAT

GACTATGCCACAAGAGAATTCCTGAATCCCGATGAGCGCATGACGTACTTGA ATCATGCTGATTACAATTTGAATTCTCCTCTAATTAGTGATGATATTGACAATT

TGATCAGGAAATTCAATTCTCTTCCGATTCCCTCGATGTGGGATAGTAAGAAC

TGGGATGGAGTTCTTGAGATGTTAACATCATGTCAAGCCAATCCCATCTCAAC

AT C T C AG AT GC AT A A AT GG AT GGG A AGT T GGT T A AT GT C T GAT A AT CAT GAT G

CC AGTC AAGGGT AT AGTTTTTT AC AT GAAGT GGAC AAAGAGGC AGAAAT AAC

ATTT GACGT GGT GGAGACCTT C ATCCGCGGCTGGGGC A AC AAACC AATTGAA

TACATCAAAAAGGAAAGATGGACTGACTCATTCAAAATTCTCGCTTATTTGTG

TCAAAAGTTTTTGGACTTACACAAGTTGACATTAATCTTAAATGCTGTCTCTG

AGGTGGAATTGCTCAACTTGGCGAGGACTTTCAAAGGCAAAGTCAGAAGAAG

TTCTCATGGAACGAACATATGCAGGATTAGGGTTCCCAGCTTGGGTCCTACTT

TTATTTCAGAAGGATGGGCTTACTTCAAGAAACTTGATATTCTAATGGACCGA

AACTTTCTGTTAATGGTCAAAGATGTGATTATAGGGAGGATGCAAACGGTGC

TATCCATGGTATGTAGAATAGACAACCTGTTCTCAGAGCAAGACATCTTCTCC

CTTCTAAATATCTACAGAATTGGAGATAAAATTGTGGAGAGGCAGGGAAATT

TTTCTTATGACTTGATTAAAATGGTGGAACCGATATGCAACTTGAAGCTGATG

AAATTAGCAAGAGAATCAAGGCCTTTAGTCCCACAATTCCCTCATTTTGAAAA

TCATATCAAGACTTCTGTTGATGAAGGGGCAAAAATTGACCGAGGTATAAGA

TTCCTCCATGATCAGATAATGAGTGTGAAAACAGTGGATCTCACACTGGTGAT

TTATGGATCGTTCAGACATTGGGGTCATCCTTTTATAGATTATTACACTGGAC

T AGAAAAATT AC ATTCCC AAGT AACC AT GAAGAAAGAT ATT GATGT GT CAT A

TGCAAAAGCACTTGCAAGTGATTTAGCTCGGATTGTTCTATTTCAACAGTTCA

ATGATCATAAAAAGTGGTTCGTGAATGGAGACTTGCTCCCTCATGATCATCCC

TTTAAAAGTCATGTTAAAGAAAATACATGGCCCACAGCTGCTCAAGTTCAAG

ATTTTGGAGATAAATGGCATGAACTTCCGCTGATTAAATGTTTTGAAATACCC

GACTTACTAGACCCATCGATAATATACTCTGACAAAAGTCATTCAATGAATA

GGTCAGAGGTGTTGAAACATGTCCGAATGAATCCGAACACTCCTATCCCTAG

T AAAAAGGTGTTGC AGACT AT GTTGGAC AC AAAGGCT ACC AATT GGAAAGAA

TTTCTT AAAGAGATT GAT GAGAAGGGCTT AG AT GAT GATGATCT AATT ATTGG

TCTT AAAGGAA AGGAGAGGGAACTGAAGTTGGC AGGT AGATTTTTCTCCCT A

ATGTCTTGGAAATTGCGAGAATACTTTGTAATTACCGAATATTTGATAAAGAC

TCATTTCGTCCCTATGTTTAAAGGCCTGACAATGGCGGACGATCTAACTGCAG

T C ATT AAAAAGAT GTT AGATTCCTC ATCCGGCC AAGGATTGAAGT CAT AT GA

GGCAATTTGCATAGCCAATCACATTGATTACGAAAAATGGAATAACCACCAA

AGGAAGTTATCAAACGGCCCAGTGTTCCGAGTTATGGGCCAGTTCTTAGGTTA TCCATCCTTAATCGAGAGAACTCATGAATTTTTTGAGAAAAGTCTTATATACT

ACAATGGAAGACCAGACTTGATGCGTGTTCACAACAACACACTGATCAATTC

AACCTCCCAACGAGTTTGTTGGCAAGGACAAGAGGGTGGACTGGAAGGTCTA

CGGCAAAAAGGATGGACTATCCTCAATCTACTGGTTATTCAAAGAGAGGCTA

AAAT C AGAAAC ACTGCTGTC AAAGTCTTGGC AC A AGGTGAT AATC AAGTT AT

TTGCACACAGTATAAAACGAAGAAATCGAGAAACGTTGTAGAATTACAGGGT

GCTCTCAATCAAATGGTTTCTAATAATGAGAAAATTATGACTGCAATCAAAAT

AGGG AC AGGG AAGTT AGGACTTTT GAT A AATGACGAT GAGACT ATGC AATCT

GCAGATTACTTGAATTATGGAAAAATACCGATTTTCCGTGGAGTGATTAGAG

GGTTAGAGACCAAGAGATGGTCACGAGTGACTTGTGTCACCAATGACCAAAT

ACCCACTTGTGCTAATATAATGAGCTCAGTTTCCACAAATGCTCTCACCGTAG

CTCATTTTGCTGAGAACCCAATCAATGCCATGATACAGTACAATTATTTTGGG

ACATTTGCTAGACTCTTGTTGATGATGCATGATCCTGCTCTTCGTCAATCATTG

TATGAAGTTCAAGATAAGATACCGGGCTTGCACAGTTCTACTTTCAAATACGC

CATGTTGTATTTGGACCCTTCCATTGGAGGAGTGTCGGGCATGTCTTTGTCCA

GGTTTTTGATTAGAGCCTTCCCAGATCCCGTAACAGAAAGTCTCTCATTCTGG

AGATTCATCCATGTACATGCTCGAAGTGAGCATCTGAAGGAGATGAGTGCAG

TATTTGGAAACCCCGAGATAGCCAAGTTTCGAATAACTCACATAGACAAGCT

AGT AGAAGATCC AACCTCTCTGAAC ATCGCT ATGGGAAT GAGTCC AGCGAAC

TTGTT AAAGACTGAGGTT AAAAAAT GCTT AATCGAAT C AAGAC AA ACC ATC A

GGA AC C AGGT GATT A AGG AT GCA ACC AT AT ATTT GT AT CAT GA AGAGGAT C G

GCTCAGAAGTTTCTTATGGTCAATAAATCCTCTGTTCCCTAGATTTTTAAGTGA

ATTCAAATCAGGCACTTTTTTGGGAGTCGCAGACGGGCTCATCAGTCTATTTC

AAAATTCTCGTACTATTCGGAACTCCTTTAAGAAAAAGTATCATAGGGAATTG

GATGATTTGATTGTGAGGAGTGAGGTATCCTCTTTGACACATTTAGGGAAACT

T C ATTTGAGAAGGGGAT C ATGT AAAATGT GGAC AT GTTC AGCT ACTC AT GCTG

ACACATTAAGATACAAATCCTGGGGCCGTACAGTTATTGGGACAACTGTACC

CCATCCATTAGAAATGTTGGGTCCACAACATCGAAAAGAGACTCCTTGTGCA

CCATGTAACACATCAGGGTTCAATTATGTTTCTGTGCATTGTCCAGACGGGAT

CCATGACGTCTTTAGTTCACGGGGACCATTGCCTGCTTATCTAGGGTCTAAAA

C ATCTGAATCT AC ATCT ATTTT GC AGCCTTGGGAAAGGGAAAGC AAAGTCCC

ACTGATTAAAAGAGCTACACGTCTTAGAGATGCTATCTCTTGGTTTGTTGAAC

CCGACTCTAAACTAGCAATGACTATACTTTCTAACATCCACTCTTTAACAGGC

GAAGAATGGACCAAAAGGCAGCATGGGTTCAAAAGAACAGGGTCTGCCCTTC ATAGGTTTTCGACATCTCGGATGAGCCATGGTGGGTTCGCATCTCAGAGCACT

GC AGC ATTGAC C AGGTTG AT GGC A ACT AC AG AC AC CAT GAGGGAT C T GGG AG

ATCAGAATTTCGACTTTTTATTCCAAGCAACGTTGCTCTATGCTCAAATTACC

ACCACTGTTGCAAGAGACGGATGGATCACCAGTTGTACAGATCATTATCATA

TTGCCTGTAAGTCCTGTTTGAGACCCATAGAAGAGATCACCCTGGACTCAAGT

ATGGACTACACGCCCCCAGATGTATCCCATGTGCTGAAGACATGGAGGAATG

GGG A AGGT T C GT GGGG AC A AG AG AT A A A AC AG AT CTATCCTTT AG A AGGG A

ATTGGAAGAATTTAGCACCTGCTGAGCAATCCTATCAAGTCGGCAGATGTAT

AGGTTTTCTATATGGAGACTTGGCGTATAGAAAATCTACTCATGCCGAGGAC

AGTTCTCTATTTCCTCTATCTATACAAGGTCGTATTAGAGGTCGAGGTTTCTTA

AAAGGGTTGCTAGACGGATTAATGAGAGCAAGTTGCTGCCAAGTAATACACC

GGAGAAGTCTGGCTCATTTGAAGAGGCCGGCCAACGCAGTGTACGGAGGTTT

GATTTACTTGATTGATAAATTGAGTGTATCACCTCCATTCCTTTCTCTTACTAG

ATCAGGACCTATTAGAGACGAATTAGAAACGATTCCCCACAAGATCCCAACC

TCCTATCCGACAAGCAACCGTGATATGGGGGTGATTGTCAGAAATTACTTCA

AAT ACC A ATGCCGTCT AATT GAAAAGGGAAAAT AC AGAT C AC ATT ATTC AC A

ATTATGGTTATTCTCAGATGTCTTATCCATAGACTTCATTGGACCATTCTCTAT

TTCCACCACCCTCTTGCAAATCCTATACAAGCCATTTTTATCTGGGAAAGATA

AGAATGAGTTGAGAGAGCTGGCAAATCTTTCTTCATTGCTAAGATCAGGAGA

GGGGT GGGAAGAC AT AC AT GT GAAATTCTTC ACC AAGGAC AT ATT ATTGT GT

CCAGAGGAAATCAGACATGCTTGCAAGTTCGGGATTGCTAAGGATAATAATA

AAGACATGAGCTATCCCCCTTGGGGAAGGGAATCCAGAGGGACAATTACAAC

AATCCCTGTTTATTATACGACCACCCCTTACCCAAAGATGCTAGAGATGCCTC

CAAGAATCCAAAATCCCCTGCTGTCCGGAATCAGGTTGGGCC AATT ACC AAC

TGGCGCTCATTATAAAATTCGGAGTATATTACATGGAATGGGAATCCATTACA

GGGACTTCTTGAGTTGTGGAGACGGCTCCGGAGGGATGACTGCTGCATTACT

ACGAGAAAATGTGCATAGCAGAGGAATATTCAATAGTCTGTTAGAATTATCA

GGGTCAGTCATGCGAGGCGCCTCTCCTGAGCCCCCCAGTGCCCTAGAAACTTT

AGGAGGAG AT A A ATCG AGAT GT GT A A AT GGT GA A AC AT GTT GGG A AT ATC C A

TCTGACTTATGTGACCCAAGGACTTGGGACTATTTCCTCCGACTCAAAGCAGG

CTTGGGGCTTCAAATTGATTTAATTGTAATGGATATGGAAGTTCGGGATTCTT

CTACTAGCCTGAAAATTGAGACGAATGTTAGAAATTATGTGCACCGGATTTTG

GAT GAGC A AGGAGTTTT AATCT AC AAGACTT AT GGAAC AT AT ATTTGT GAGA

GCGAAAAGAATGCAGTAACAATCCTTGGTCCCATGTTCAAGACGGTCGACTT AGTTCAAACAGAATTTAGTAGTTCTCAAACGTCTGAAGTATATATGGTATGTA

AAGGTTTGAAGAAATTAATCGATGAACCCAATCCCGATTGGTCTTCCATCAAT

GAATCCTGGAAAAACCTGTACGCATTCCAGTCATCAGAACAGGAATTTGCCA

GAGCAAAGAAGGTTAGTACATACTTTACCTTGACAGGTATTCCCTCCCAATTC

ATTCCTGATCCTTTTGTAAACATTGAGACTATGCTACAAATATTCGGAGTACC

CACGGGTGTGTCTCATGCGGCTGCCTTAAAATCATCTGATAGACCTGCAGATT

TATTGACCATTAGCCTTTTTTATATGGCGATTATATCGTATTATAACATCAATC

ATATCAGAGTAGGACCGATACCTCCGAACCCCCCATCAGATGGAATTGCACA

AAATGTGGGGATCGCTATAACTGGTATAAGCTTTTGGCTGAGTTTGATGGAGA

AAGACATTCCACTATATCAACAGTGTTTAGCAGTTATCCAGCAATCATTCCCG

ATT AGGT GGGAGGCTGTTTC AGT AAA AGGAGGAT AC AAGC AGAAGT GGAGT A

CTAGAGGTGATGGGCTCCCAAAAGATACCCGAACTTCAGACTCCTTGGCCCC

AATCGGGAACTGGATCAGATCTCTGGAATTGGTCCGAAACCAAGTTCGTCTA

AATCCATTCAATGAGATCTTGTTCAATCAGCTATGTCGTACAGTGGATAATCA

TTT GA A AT GGT C A A ATTTGC GA AGA A AC AC AGGA AT GATTGA AT GGAT C A AT

AGACGAATTTC AAAAGAAGACCGGTCT AT ACTGAT GTT GAAGAGT GACCT AC

ACGAGGAAAACTCTTGGAGAGATTAAAAAATCATGAGGAGACTCCAAACTTT

AAGTATGAAAAAAACTTTGATCCTTAAGACCCTCTTGTGGTTTTTATTTTTTAT

CTGGTTTTGTGGTCTTCGT.

In one embodiment, the nucleic acid comprises the sequence of SEQ ID NO: 26, shown below (VSV vector: Convac V5 China):

ACGAAGAC AAAC AAACC ATT ATT AT C ATT AAAAGGCTC AGGAGAAACTTT AA C AGT AAT C AAA ATGTCTGTT AC AGTC AAGAGAAT C ATTGAC AAC AC AGTC AT AGTTCCAAAACTTCCTGCAAATGAGGATCCAGTGGAATACCCGGCAGATTAC TTCAGAAAATCAAAGGAGATTCCTCTTTACATCAATACTACAAAAAGTTTGTC AGATCTAAGAGGATATGTCTACCAAGGCCTCAAATCCGGAAATGTATCAATC AT AC AT GT C A AC AGC T AC TT GT AT GG AGC ATT A A AGG AC ATC C GGGGT A AGT T GGAT A A AG AT T GGT C A AGTT T C GG A AT AAAC ATC GGG A A AGC AGGGG AT AC AATCGGAATATTTGACCTTGTATCCTTGAAAGCCCTGGACGGCGTACTTCCAG AT GGAGT ATCGG AT GCTTCC AGAACC AGCGC AGAT GAC AAAT GGTT GCCTTT GT AT C T AC TT GGCTT AT AC AG AGT GGGC AG A AC AC A A AT GCC T GA AT AC AGA A A A A AGC TC AT GGAT GGGC T GAC A A AT C A AT GCA A A AT GAT C A AT GA AC AGT TTGAACCTCTTGTGCCAGAAGGTCGTGACATTTTTGATGTGTGGGGAAATGAC AGTAATTACACAAAAATTGTCGCTGCAGTGGACATGTTCTTCCACATGTTCAA AAAACATGAATGTGCCTCGTTCAGATACGGAACTATTGTTTCCAGATTCAAAG

ATTGTGCTGCATTGGCAACATTTGGACACCTCTGCAAAATAACCGGAATGTCT

ACAGAAGATGTAACGACCTGGATCTTGAACCGAGAAGTTGCAGATGAAATGG

TCCAAATGATGCTTCCAGGCCAAGAAATTGACAAGGCCGATTCATACATGCC

TTATTTGATCGACTTTGGATTGTCTTCTAAGTCTCCATATTCTTCCGTCAAAAA

CCCTGCCTTCCACTTCTGGGGGCAATTGACAGCTCTTCTGCTCAGATCCACCA

GAGCAAGGAATGCCCGACAGCCTGATGACATTGAGTATACATCTCTTACTAC

AGCAGGTTTGTTGTACGCTTATGCAGTAGGATCCTCTGCCGACTTGGCACAAC

AGTTTTGTGTTGGAGATAACAAATACACTCCAGATGATAGTACCGGAGGATT

GACGACTAATGCACCGCCACAAGGCAGAGATGTGGTCGAATGGCTCGGATGG

T TT G A AG AT C A A A AC AG A A A AC C G AC TC C T GAT AT GAT GC AGT AT GC G A A A A

GAGCAGTCATGTCACTGCAAGGCCTAAGAGAGAAGACAATTGGCAAGTATGC

TAAGTCAGAATTTGACAAATGACCCTATAATTCTCAGATCACCTATTATATAT

TATGCTACATATGAAAAAAACTAACAGATATCATGGATAATCTCACAAAAGT

TCGTGAGTATCTCAAGTCCTATTCTCGTCTGGATCAGGCGGTAGGAGAGATAG

ATGAGATCGAAGCACAACGAGCTGAAAAGTCCAATTATGAGTTGTTCCAAGA

GGATGGAGTGGAAGAGCATACTAAGCCCTCTTATTTTCAGGCAGCAGATGAT

TCTGAC AC AGA AT C T GA AC C AG A A ATT GA AG AC A AT C A AGGTTT GT AT GC AC

CAGATCCAGAAGCTGAGCAAGTTGAAGGCTTTATACAGGGGCCTTTAGATGA

CT AT GC AGAT GAGGAAGT GGAT GTT GT ATTT ACTTCGGACTGGAAAC AGCCT

GAGCTTGAATCTGACGAGCATGGAAAGACCTTACGGTTGACATCGCCAGAGG

GTTTAAGTGGAGAGCAGAAATCCCAGTGGCTTTCGACGATTAAAGCAGTCGT

GC AAAGTGCC AAAT ACTGGAATCTGGC AGAGT GC AC ATTTGAAGC ATCGGGA

G A AGGGGT C AT T AT G A AGG AGC GC C AG AT A AC T C C GGAT GT AT AT A AGGT C A

CTCCAGTGATGAACACACATCCGTCCCAATCAGAAGCAGTATCAGATGTTTG

GTCTCTCTCAAAGACATCCATGACTTTCCAACCCAAGAAAGCAAGTCTTCAGC

CTCTCACCATATCCTTGGATGAATTGTTCTCATCTAGAGGAGAGTTCATCTCT

GTCGGAGGTGACGGACGAATGTCTCATAAAGAGGCCATCCTGCTCGGCCTGA

GATACAAAAAGTTGTACAATCAGGCGAGAGTCAAATATTCTCTGTAGACTAT

GAAAAAAAGTAACAGATATCACGATCTAAGTGTTATCCCAATCCATTCATCA

T G AGTT C C TT A A AG A AG AT TC TC GGT C T G A AGGGG A A AGGT A AG A A AT C T A A

GAAATTAGGGATCGCACCACCCCCTTATGAAGAGGACACTAGCATGGAGTAT

GCTCCGAGCGCTCCAATTGACAAATCCTATTTTGGAGTTGACGAGATGGACA

CCTATGATCCGAATCAATTAAGATATGAGAAATTCTTCTTTACAGTGAAAATG ACGGTTAGATCTAATCGTCCGTTCAGAACATACTCAGATGTGGCAGCCGCTGT

ATCCCATTGGGATCACATGTACATCGGAATGGCAGGGAAACGTCCCTTCTAC

AAAATCTTGGCTTTTTTGGGTTCTTCTAATCTAAAGGCCACTCCAGCGGTATT

GGCAGATCAAGGTCAACCAGAGTATCACACTCACTGCGAAGGCAGGGCTTAT

TTGCCACATAGGATGGGGAAGACCCCTCCCATGCTCAATGTACCAGAGCACT

T C AGAAGACC ATTC AAT AT AGGTCTTT AC AAGGGAACGATTGAGCTC AC A AT

GACCATCTACGATGATGAGTCACTGGAAGCAGCTCCTATGATCTGGGATCATT

TCAATTCTTCCAAATTTTCTGATTTCAGAGAGAAGGCCTTAATGTTTGGCCTG

ATTGTCGAGAAAAAGGCATCTGGAGCGTGGGTCCTGGATTCTATCAGCCACT

TCAAATGAGCTAGTCTAACTTCTAGCTTCTGAACAATCCCCGGTTTACTCAGT

CTCTCCTAATTCCAGCCTCTCGAACAACTAATATCCTGTCTTTTCTATCCCTAT

GAAAAAAACTAACAGAGATCGATCTGTTTACGCGTCACTATGAAGTGCCTTTT

GTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCC

ACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGC

CCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCATAC

A AGT C A A A AT GCC C A AGAGTC AC A AGGC T ATT C A AGC AGACGGTT GGAT GT G

TCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGT

ATATAACACAGTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGA

AAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCT

C AAAGTT GTGGAT AT GC AACTGT GACGGAT GCCGAAGC AGT GATTGTCC AGG

TGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCA

CAGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTC

TACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCA

TTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGA

AAGGAGGGC AC AGGGTT C AGAAGT AACT ACTTTGCTT AT GAAACTGGAGGC A

AGGCCTGC AAAAT GC AAT ACTGC AAGC ATT GGGGAGTC AGACTCCC ATC AGG

TGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTG

AATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTA

AGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAAC

CTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATC

TTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACC

CTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCT

C T C A AG A AT GGT C GG A AT GAT C AGT GG A AC T AC C AC AG A A AGGG A AC TGT GG

GAT GACTGGGC ACC AT AT GAAGACGT GGAAATTGGACCC AAT GGAGTTCTGA GGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTG

GACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACAT

TCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATA

CTGGGCT ATCC AAAAATCC AATCGAGCTTGT AGAAGGTT GGTTC AGT AGTT G

GAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATT

CTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGA

AAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACTCAA

ATCCTGCTAGGTATGAAAAAAACTAACaGATATCACGCtcgagGCCACCATGAA

GTGCCTGTTGTACTTAGCCTTCCTGTTCATCGGGGTGAATTGCCGCTTTCCCAA

TATCACAAACCTGTGCCCTTTTGGCGAGGTGTTCAACGCAACCCGCTTCGCCA

GCGTGTACGCCTGGAATAGGAAGCGCATCTCCAACTGCGTGGCCGACTATTC

TGTGCTGTACAACAGCGCCTCCTTCTCTACCTTTAAGTGCTATGGCGTGAGCC

CCACAAAGCTGAATGACCTGTGCTTTACCAACGTGTACGCCGATTCCTTCGTG

ATCAGGGGCGACGAGGTGCGCCAGATCGCACCAGGACAGACAGGCAAGATC

GCAGACTACAATTATAAGCTGCCTGACGATTTCACCGGCTGCGTGATCGCCTG

GAACTCTAACAATCTGGATAGCAAAGTGGGCGGCAACTACAATTATCTGTAC

CGGCTGTTTAGAAAGTCTAATCTGAAGCCATTCGAGAGGGACATCTCCACAG

AAATCTACCAGGCCGGCTCTACCCCCTGCAATGGCGTGGAGGGCTTTAACTGT

TATTTCCCTCTGCAGAGCTACGGCTTCCAGCCAACAAACGGCGTGGGCTATCA

GCCCTACCGCGTGGTGGTGCTGTCTTTTGAGCTGCTGCACGCACCTGCAACAG

T GTGCGGACC AA AGAAGAGC ACC AATCTGGT GAAGAAC AAGT GCGT GAACTT

CAAcggCTCTGGATCCGGCTACATCCCCGAGGCCCCCAGAGACGGCCAGGCCT

ACGTGCGGAAGGACGGCGAGTGGGTACTGctcagcaccttcctgggcAGCAGTTGGAA

AAGCTCCATCGCCTCCTTTTTCTTTATCATCGGCCTGATCATCGGACTGTTCCT

GGTGCTCCGCGTGGGTATCCACCTGTGCATCAAGCTGAAGCACACCAAGAAA

AGACAGATTTATACAGACATCGAGATGAACCGACTTGGAAAGTAAGCTAGCC

AGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCC

T C AATT AT ATTTGAGTTTTT AATTTTT AT GAAAA AAACT AAC AGC AAT CAT GG

AAGTCC ACGATTTTGAGACCGACGAGTTC AAT GATTT C AAT GAAGATGACT A

TGCCACAAGAGAATTCCTGAATCCCGATGAGCGCATGACGTACTTGAATCAT

GCTGATTACAATTTGAATTCTCCTCTAATTAGTGATGATATTGACAATTTGATC

AGGAAATTCAATTCTCTTCCGATTCCCTCGATGTGGGATAGTAAGAACTGGGA

TGGAGTTCTTGAGATGTTAACATCATGTCAAGCCAATCCCATCTCAACATCTC

AG AT GC AT A A AT GGAT GGGA AGTT GGTT AAT GT C T GAT AAT CAT GAT GC C AG T C AAGGGT AT AGTTTTTT AC AT GAAGT GGAC AAAGAGGC AGAAAT AAC ATTT

GACGTGGTGGAGACCTTCATCCGCGGCTGGGGCAACAAACCAATTGAATACA

T C AAAAAGGAAAGAT GGACTGACTC ATTC AAAATTCTCGCTT ATTTGTGT C AA

AAGTTTTTGGACTTACACAAGTTGACATTAATCTTAAATGCTGTCTCTGAGGT

GGAATTGCTCAACTTGGCGAGGACTTTCAAAGGCAAAGTCAGAAGAAGTTCT

CATGGAACGAACATATGCAGGATTAGGGTTCCCAGCTTGGGTCCTACTTTTAT

TTCAGAAGGATGGGCTTACTTCAAGAAACTTGATATTCTAATGGACCGAAAC

T TT C T GTT A AT GGT C A A AG AT GT GAT TAT AGGG AGG AT GCA A AC GGT GC T AT C

CATGGTATGTAGAATAGACAACCTGTTCTCAGAGCAAGACATCTTCTCCCTTC

T AAAT ATCT AC AGA ATT GGAGAT AAAATTGT GGAGAGGC AGGGAAATTTTTC

TTATGACTTGATTAAAATGGTGGAACCGATATGCAACTTGAAGCTGATGAAA

TTAGCAAGAGAATCAAGGCCTTTAGTCCCACAATTCCCTCATTTTGAAAATCA

TATCAAGACTTCTGTTGATGAAGGGGCAAAAATTGACCGAGGTATAAGATTC

CTCCATGATCAGATAATGAGTGTGAAAACAGTGGATCTCACACTGGTGATTT

AT GGAT C GTT C AG AC ATT GGGGT C ATCC TTTT AT AG ATT ATT AC AC T GGACT A

GAAAAATTACATTCCCAAGTAACCATGAAGAAAGATATTGATGTGTCATATG

CAAAAGCACTTGCAAGTGATTTAGCTCGGATTGTTCTATTTCAACAGTTCAAT

GATCATAAAAAGTGGTTCGTGAATGGAGACTTGCTCCCTCATGATCATCCCTT

T A A A AGT CAT GTT A A AGA A A AT AC AT GGCC C AC AGCTGC TC A AGTT C A AGAT

TTTGGAGATAAATGGCATGAACTTCCGCTGATTAAATGTTTTGAAATACCCGA

CTTACTAGACCCATCGATAATATACTCTGACAAAAGTCATTCAATGAATAGGT

CAGAGGTGTTGAAACATGTCCGAATGAATCCGAACACTCCTATCCCTAGTAA

AAAGGTGTTGCAGACTATGTTGGACACAAAGGCTACCAATTGGAAAGAATTT

CTT AAAGAGATT GAT GAG AAGGGCTT AGAT GATGATGATCT AATT ATTGGTCT

TAAAGGAAAGGAGAGGGAACTGAAGTTGGCAGGTAGATTTTTCTCCCTAATG

TCTTGGAAATTGCGAGAATACTTTGTAATTACCGAATATTTGATAAAGACTCA

TTTCGTCCCTATGTTTAAAGGCCTGACAATGGCGGACGATCTAACTGCAGTCA

TTAAAAAGATGTTAGATTCCTCATCCGGCCAAGGATTGAAGTCATATGAGGC

AATTTGCATAGCCAATCACATTGATTACGAAAAATGGAATAACCACCAAAGG

AAGTTATCAAACGGCCCAGTGTTCCGAGTTATGGGCCAGTTCTTAGGTTATCC

ATCCTTAATCGAGAGAACTCATGAATTTTTTGAGAAAAGTCTTATATACTACA

ATGGAAGACCAGACTTGATGCGTGTTCACAACAACACACTGATCAATTCAAC

CTCCCAACGAGTTTGTTGGCAAGGACAAGAGGGTGGACTGGAAGGTCTACGG

CAAAAAGGATGGACTATCCTCAATCTACTGGTTATTCAAAGAGAGGCTAAAA T C AG A A AC AC T GCTGT C A A AGT C TT GGC AC A AGGT GAT A AT C A AGTT ATTT GC

AC AC AGT AT A A A ACGA AG A A AT C GAGA A AC GTT GT AG A ATT AC AGGGT GC T C

T C A AT C A A AT GGTTTCT A AT A AT GAGA A A ATT AT GAC T GCA AT C A A A AT AGG

GAC AGGGAAGTT AGGACTTTT GAT AAAT GACGAT GAGACT AT GC AATCTGC A

GATTACTTGAATTATGGAAAAATACCGATTTTCCGTGGAGTGATTAGAGGGTT

AG AG AC C A AG AG AT GGT C AC GAGT GACTTGT GT C AC C A AT GACC A A AT AC CC

ACTTGTGCTAATATAATGAGCTCAGTTTCCACAAATGCTCTCACCGTAGCTCA

TTTTGCTGAGAACCC AAT C AAT GCC ATGAT AC AGT AC A ATT ATTTT GGGAC AT

TTGCTAGACTCTTGTTGATGATGCATGATCCTGCTCTTCGTCAATCATTGTATG

AAGTTCAAGATAAGATACCGGGCTTGCACAGTTCTACTTTCAAATACGCCATG

TTGTATTTGGACCCTTCCATTGGAGGAGTGTCGGGCATGTCTTTGTCCAGGTTT

TTGATTAGAGCCTTCCCAGATCCCGTAACAGAAAGTCTCTCATTCTGGAGATT

CATCCATGTACATGCTCGAAGTGAGCATCTGAAGGAGATGAGTGCAGTATTT

GGAAACCCCGAGATAGCCAAGTTTCGAATAACTCACATAGACAAGCTAGTAG

AAGATCCAACCTCTCTGAACATCGCTATGGGAATGAGTCCAGCGAACTTGTT

AAAGACTGAGGTTAAAAAATGCTTAATCGAATCAAGACAAACCATCAGGAAC

CAGGTGATTAAGGATGCAACCATATATTTGTATCATGAAGAGGATCGGCTCA

GAAGTTTCTTATGGTCAATAAATCCTCTGTTCCCTAGATTTTTAAGTGAATTCA

AATCAGGCACTTTTTTGGGAGTCGCAGACGGGCTCATCAGTCTATTTCAAAAT

TCTCGTACTATTCGGAACTCCTTTAAGAAAAAGTATCATAGGGAATTGGATGA

TTTGATTGTGAGGAGTGAGGTATCCTCTTTGACACATTTAGGGAAACTTCATT

T GAGA AGGGGAT CAT GT A A A AT GT GGAC AT GTT C AGC T ACTC AT GCTGAC AC

ATTAAGATACAAATCCTGGGGCCGTACAGTTATTGGGACAACTGTACCCCAT

CCATTAGAAATGTTGGGTCCACAACATCGAAAAGAGACTCCTTGTGCACCAT

GTAACACATCAGGGTTCAATTATGTTTCTGTGCATTGTCCAGACGGGATCCAT

GACGTCTTTAGTTCACGGGGACCATTGCCTGCTTATCTAGGGTCTAAAACATC

TGAATCTACATCTATTTTGCAGCCTTGGGAAAGGGAAAGCAAAGTCCCACTG

ATTAAAAGAGCTACACGTCTTAGAGATGCTATCTCTTGGTTTGTTGAACCCGA

CTCTAAACTAGCAATGACTATACTTTCTAACATCCACTCTTTAACAGGCGAAG

AATGGACCAAAAGGCAGCATGGGTTCAAAAGAACAGGGTCTGCCCTTCATAG

GTTTTCGACATCTCGGATGAGCCATGGTGGGTTCGCATCTCAGAGCACTGCAG

C ATTGACC AGGTT GATGGC AACT AC AGAC ACC ATGAGGGATCTGGGAGAT C A

GAATTTCGACTTTTTATTCCAAGCAACGTTGCTCTATGCTCAAATTACCACCA

CTGTTGCAAGAGACGGATGGATCACCAGTTGTACAGATCATTATCATATTGCC TGTAAGTCCTGTTTGAGACCCATAGAAGAGATCACCCTGGACTCAAGTATGG

ACTACACGCCCCCAGATGTATCCCATGTGCTGAAGACATGGAGGAATGGGGA

AGGTTCGTGGGGAC AAGAGAT AAAAC AGATCT ATCCTTT AGAAGGGAATTGG

AAGAATTTAGCACCTGCTGAGCAATCCTATCAAGTCGGCAGATGTATAGGTTT

TCTATATGGAGACTTGGCGTATAGAAAATCTACTCATGCCGAGGACAGTTCTC

TATTTCCTCTATCTATACAAGGTCGTATTAGAGGTCGAGGTTTCTTAAAAGGG

TTGCT AGACGGATT AAT GAGAGC A AGTT GCTGCC AAGT AAT AC ACCGGAGAA

GTCTGGCTCATTTGAAGAGGCCGGCCAACGCAGTGTACGGAGGTTTGATTTA

CTTGATTGATAAATTGAGTGTATCACCTCCATTCCTTTCTCTTACTAGATCAGG

ACCTATTAGAGACGAATTAGAAACGATTCCCCACAAGATCCCAACCTCCTAT

CCGACAAGCAACCGTGATATGGGGGTGATTGTCAGAAATTACTTCAAATACC

AATGCCGTCTAATTGAAAAGGGAAAATACAGATCACATTATTCACAATTATG

GTTATTCTCAGATGTCTTATCCATAGACTTCATTGGACCATTCTCTATTTCCAC

CACCCTCTTGCAAATCCTATACAAGCCATTTTTATCTGGGAAAGATAAGAATG

AGTTGAGAGAGCTGGCAAATCTTTCTTCATTGCTAAGATCAGGAGAGGGGTG

GGA AGAC AT AC AT GT GA A ATTC TT C AC C A AGGAC AT ATT ATT GT GT C C AGAG

GAAAT C AG AC AT GCTTGC AAGTTCGGGATTGCT AAGGAT AAT A AT AAAGAC A

TGAGCTATCCCCCTTGGGGAAGGGAATCCAGAGGGACAATTACAACAATCCC

TGTTTATTATACGACCACCCCTTACCCAAAGATGCTAGAGATGCCTCCAAGAA

TCCAAAATCCCCTGCTGTCCGGAATCAGGTTGGGCCAATTACCAACTGGCGCT

CATTATAAAATTCGGAGTATATTACATGGAATGGGAATCCATTACAGGGACTT

CTTGAGTTGTGGAGACGGCTCCGGAGGGATGACTGCTGCATTACTACGAGAA

AATGTGCATAGCAGAGGAATATTCAATAGTCTGTTAGAATTATCAGGGTCAG

TCATGCGAGGCGCCTCTCCTGAGCCCCCCAGTGCCCTAGAAACTTTAGGAGG

AG AT A A AT C GAG AT GT GT A A AT GGT G A A AC AT GT T GGG A AT ATCCATCT G AC

TTATGTGACCCAAGGACTTGGGACTATTTCCTCCGACTCAAAGCAGGCTTGGG

GCTTCAAATTGATTTAATTGTAATGGATATGGAAGTTCGGGATTCTTCTACTA

GCCTGAAAATTGAGACGAATGTTAGAAATTATGTGCACCGGATTTTGGATGA

GC A AGGAGTTTT AATCT AC AAGACTT AT GGAAC AT AT ATTTGT GAGAGC GAA

A AG A AT GC AGT A AC A AT C CTT GGTCC C AT GTT C A AGAC GGTCGAC TT AGTT C A

AACAGAATTTAGTAGTTCTCAAACGTCTGAAGTATATATGGTATGTAAAGGTT

TGAAGAAATTAATCGATGAACCCAATCCCGATTGGTCTTCCATCAATGAATCC

TGGAAAAACCTGTACGCATTCCAGTCATCAGAACAGGAATTTGCCAGAGCAA

AGAAGGTTAGTACATACTTTACCTTGACAGGTATTCCCTCCCAATTCATTCCT GATCCTTTTGTAAACATTGAGACTATGCTACAAATATTCGGAGTACCCACGGG

TGTGTCTCATGCGGCTGCCTTAAAATCATCTGATAGACCTGCAGATTTATTGA

CCATTAGCCTTTTTTATATGGCGATTATATCGTATTATAACATCAATCATATCA

GAGTAGGACCGATACCTCCGAACCCCCCATCAGATGGAATTGCACAAAATGT

GGGGATCGCTATAACTGGTATAAGCTTTTGGCTGAGTTTGATGGAGAAAGAC

ATTCCACTATATCAACAGTGTTTAGCAGTTATCCAGCAATCATTCCCGATTAG

GT GGGAGGCTGTTTC AGT AAAAGGAGGAT AC AAGC AGAAGT GGAGT ACT AG

AGGTGATGGGCTCCCAAAAGATACCCGAACTTCAGACTCCTTGGCCCCAATC

GGGAACTGGATCAGATCTCTGGAATTGGTCCGAAACCAAGTTCGTCTAAATC

CATTCAATGAGATCTTGTTCAATCAGCTATGTCGTACAGTGGATAATCATTTG

AAAT GGT C AAATTT GCGAAGAAAC AC AGGAAT GATT GAAT GGATC AAT AGAC

GAATTTCAAAAGAAGACCGGTCTATACTGATGTTGAAGAGTGACCTACACGA

GGA A A AC TC TT GGAGAGATT A A A A A AT CAT GAGGAGACTCC A A AC TTT A AGT

ATGAAAAAAACTTTGATCCTTAAGACCCTCTTGTGGTTTTTATTTTTTATCTGG

TTTTGTGGTCTTCGT.

In other embodiments, the nucleic acid comprises the sequence of SEQ ID NO:

27, shown below (VSV vector: Convac V5 South Africa):

ACGAAGAC AAAC AAACC ATT ATT AT C ATT AAAAGGCTC AGGAGAAACTTT AA

C AGT AAT C AAA ATGTCTGTT AC AGTC AAGAGAAT C ATTGAC AAC AC AGTC AT

AGTTCCAAAACTTCCTGCAAATGAGGATCCAGTGGAATACCCGGCAGATTAC

TTCAGAAAATCAAAGGAGATTCCTCTTTACATCAATACTACAAAAAGTTTGTC

AGATCTAAGAGGATATGTCTACCAAGGCCTCAAATCCGGAAATGTATCAATC

AT AC AT GT C A AC AGC T AC TT GT AT GG AGC ATT A A AGG AC ATC C GGGGT A AGT

T GG AT A A AG AT T GGT C A AGTT T C GGA AT AAAC ATC GGG A A AGC AGGGG AT AC

AATCGGAATATTTGACCTTGTATCCTTGAAAGCCCTGGACGGCGTACTTCCAG

AT GGAGT ATCGG AT GCTTCC AGAACC AGCGC AGAT GAC AAAT GGTT GCCTTT

GTATCTACTTGGCTTATACAGAGTGGGCAGAACACAAATGCCTGAATACAGA

A A A A AGC TC AT GGAT GGGC T GAC A A AT C A AT GCA A A AT GAT C A AT GA AC AGT

TTGAACCTCTTGTGCCAGAAGGTCGTGACATTTTTGATGTGTGGGGAAATGAC

AGTAATTACACAAAAATTGTCGCTGCAGTGGACATGTTCTTCCACATGTTCAA

AAAACATGAATGTGCCTCGTTCAGATACGGAACTATTGTTTCCAGATTCAAAG

ATTGTGCTGCATTGGCAACATTTGGACACCTCTGCAAAATAACCGGAATGTCT

ACAGAAGATGTAACGACCTGGATCTTGAACCGAGAAGTTGCAGATGAAATGG

TCCAAATGATGCTTCCAGGCCAAGAAATTGACAAGGCCGATTCATACATGCC TTATTTGATCGACTTTGGATTGTCTTCTAAGTCTCCATATTCTTCCGTCAAAAA

CCCTGCCTTCCACTTCTGGGGGCAATTGACAGCTCTTCTGCTCAGATCCACCA

GAGCAAGGAATGCCCGACAGCCTGATGACATTGAGTATACATCTCTTACTAC

AGCAGGTTTGTTGTACGCTTATGCAGTAGGATCCTCTGCCGACTTGGCACAAC

AGTTTTGTGTTGGAGATAACAAATACACTCCAGATGATAGTACCGGAGGATT

GACGACTAATGCACCGCCACAAGGCAGAGATGTGGTCGAATGGCTCGGATGG

T TT G A AG AT C A A A AC AG A A A AC C G AC TC C T GAT AT GAT GC AGT AT GC G A A A A

GAGCAGTCATGTCACTGCAAGGCCTAAGAGAGAAGACAATTGGCAAGTATGC

TAAGTCAGAATTTGACAAATGACCCTATAATTCTCAGATCACCTATTATATAT

TATGCTACATATGAAAAAAACTAACAGATATCATGGATAATCTCACAAAAGT

TCGTGAGTATCTCAAGTCCTATTCTCGTCTGGATCAGGCGGTAGGAGAGATAG

ATGAGATCGAAGCACAACGAGCTGAAAAGTCCAATTATGAGTTGTTCCAAGA

GGATGGAGTGGAAGAGCATACTAAGCCCTCTTATTTTCAGGCAGCAGATGAT

TCTGAC AC AGA AT C T GA AC C AG A A ATT GA AG AC A AT C A AGGTTT GT AT GC AC

CAGATCCAGAAGCTGAGCAAGTTGAAGGCTTTATACAGGGGCCTTTAGATGA

CT AT GC AGAT GAGGAAGT GGAT GTT GT ATTT ACTTCGGACTGGAAAC AGCCT

GAGCTTGAATCTGACGAGCATGGAAAGACCTTACGGTTGACATCGCCAGAGG

GTTTAAGTGGAGAGCAGAAATCCCAGTGGCTTTCGACGATTAAAGCAGTCGT

GC AAAGTGCC AAAT ACTGGAATCTGGC AGAGT GC AC ATTTGAAGC ATCGGGA

G A AGGGGT C AT T AT G A AGG AGC GC C AG AT A AC T C C GGAT GT AT AT A AGGT C A

CTCCAGTGATGAACACACATCCGTCCCAATCAGAAGCAGTATCAGATGTTTG

GTCTCTCTCAAAGACATCCATGACTTTCCAACCCAAGAAAGCAAGTCTTCAGC

CTCTCACCATATCCTTGGATGAATTGTTCTCATCTAGAGGAGAGTTCATCTCT

GTCGGAGGTGACGGACGAATGTCTCATAAAGAGGCCATCCTGCTCGGCCTGA

GATACAAAAAGTTGTACAATCAGGCGAGAGTCAAATATTCTCTGTAGACTAT

GAAAAAAAGTAACAGATATCACGATCTAAGTGTTATCCCAATCCATTCATCA

T G AGTT C C TT A A AG A AG AT TC TC GGT C T G A AGGGG A A AGGT A AG A A AT C T A A

GAAATTAGGGATCGCACCACCCCCTTATGAAGAGGACACTAGCATGGAGTAT

GCTCCGAGCGCTCCAATTGACAAATCCTATTTTGGAGTTGACGAGATGGACA

CCTATGATCCGAATCAATTAAGATATGAGAAATTCTTCTTTACAGTGAAAATG

ACGGTTAGATCTAATCGTCCGTTCAGAACATACTCAGATGTGGCAGCCGCTGT

ATCCCATTGGGATCACATGTACATCGGAATGGCAGGGAAACGTCCCTTCTAC

AAAATCTTGGCTTTTTTGGGTTCTTCTAATCTAAAGGCCACTCCAGCGGTATT

GGCAGATCAAGGTCAACCAGAGTATCACACTCACTGCGAAGGCAGGGCTTAT TTGCCACATAGGATGGGGAAGACCCCTCCCATGCTCAATGTACCAGAGCACT

T C AGAAGACC ATTC AAT AT AGGTCTTT AC AAGGGAACGATTGAGCTC AC A AT

GACCATCTACGATGATGAGTCACTGGAAGCAGCTCCTATGATCTGGGATCATT

TCAATTCTTCCAAATTTTCTGATTTCAGAGAGAAGGCCTTAATGTTTGGCCTG

ATTGTCGAGAAAAAGGCATCTGGAGCGTGGGTCCTGGATTCTATCAGCCACT

TCAAATGAGCTAGTCTAACTTCTAGCTTCTGAACAATCCCCGGTTTACTCAGT

CTCTCCTAATTCCAGCCTCTCGAACAACTAATATCCTGTCTTTTCTATCCCTAT

GAAAAAAACTAACAGAGATCGATCTGTTTACGCGTCACTATGAAGTGCCTTTT

GTACTTAGCCTTTTTATTCATTGGGGTGAATTGCAAGTTCACCATAGTTTTTCC

ACACAACCAAAAAGGAAACTGGAAAAATGTTCCTTCTAATTACCATTATTGC

CCGTCAAGCTCAGATTTAAATTGGCATAATGACTTAATAGGCACAGCCATAC

A AGT C A A A AT GCC C A AGAGTC AC A AGGC T ATT C A AGC AGACGGTT GGAT GT G

TCATGCTTCCAAATGGGTCACTACTTGTGATTTCCGCTGGTATGGACCGAAGT

ATATAACACAGTCCATCCGATCCTTCACTCCATCTGTAGAACAATGCAAGGA

AAGCATTGAACAAACGAAACAAGGAACTTGGCTGAATCCAGGCTTCCCTCCT

C AAAGTT GTGGAT AT GC AACTGT GACGGAT GCCGAAGC AGT GATTGTCC AGG

TGACTCCTCACCATGTGCTGGTTGATGAATACACAGGAGAATGGGTTGATTCA

CAGTTCATCAACGGAAAATGCAGCAATTACATATGCCCCACTGTCCATAACTC

TACAACCTGGCATTCTGACTATAAGGTCAAAGGGCTATGTGATTCTAACCTCA

TTTCCATGGACATCACCTTCTTCTCAGAGGACGGAGAGCTATCATCCCTGGGA

AAGGAGGGC AC AGGGTT C AGAAGT AACT ACTTTGCTT AT GAAACTGGAGGC A

AGGCCTGC AAAAT GC AAT ACTGC AAGC ATT GGGGAGTC AGACTCCC ATC AGG

TGTCTGGTTCGAGATGGCTGATAAGGATCTCTTTGCTGCAGCCAGATTCCCTG

AATGCCCAGAAGGGTCAAGTATCTCTGCTCCATCTCAGACCTCAGTGGATGTA

AGTCTAATTCAGGACGTTGAGAGGATCTTGGATTATTCCCTCTGCCAAGAAAC

CTGGAGCAAAATCAGAGCGGGTCTTCCAATCTCTCCAGTGGATCTCAGCTATC

TTGCTCCTAAAAACCCAGGAACCGGTCCTGCTTTCACCATAATCAATGGTACC

CTAAAATACTTTGAGACCAGATACATCAGAGTCGATATTGCTGCTCCAATCCT

C T C A AG A AT GGT C GG A AT GAT C AGT GG A AC T AC C AC AG A A AGGG A AC TGT GG

GAT GACTGGGC ACC AT AT GAAGACGT GGAAATTGGACCC AAT GGAGTTCTGA

GGACCAGTTCAGGATATAAGTTTCCTTTATACATGATTGGACATGGTATGTTG

GACTCCGATCTTCATCTTAGCTCAAAGGCTCAGGTGTTCGAACATCCTCACAT

TCAAGACGCTGCTTCGCAACTTCCTGATGATGAGAGTTTATTTTTTGGTGATA

CTGGGCT ATCC AAAAATCC AATCGAGCTTGT AGAAGGTT GGTTC AGT AGTT G GAAAAGCTCTATTGCCTCTTTTTTCTTTATCATAGGGTTAATCATTGGACTATT

CTTGGTTCTCCGAGTTGGTATCCATCTTTGCATTAAATTAAAGCACACCAAGA

AAAGACAGATTTATACAGACATAGAGATGAACCGACTTGGAAAGTAACTCAA

ATCCTGCTAGGTATGAAAAAAACTAACaGATATCACGCtcgagGCCACCATGAA

GTGCCTGTTGTACTTAGCCTTCCTGTTCATCGGGGTGAATTGCCGCTTTCCCAA

TATCACAAACCTGTGCCCTTTTGGCGAGGTGTTCAACGCAACCCGCTTCGCCA

GCGTGTACGCCTGGAATAGGAAGCGCATCTCCAACTGCGTGGCCGACTATTC

TGTGCTGTACAACAGCGCCTCCTTCTCTACCTTTAAGTGCTATGGCGTGAGCC

CCACAAAGCTGAATGACCTGTGCTTTACCAACGTGTACGCCGATTCCTTCGTG

AT C AGGGGC GACGAGGT GCGC C AGAT C GC AC C AGGAC AGAC AGGC A AT AT C

GCAGACTACAATTATAAGCTGCCTGACGATTTCACCGGCTGCGTGATCGCCTG

GAACTCTAACAATCTGGATAGCAAAGTGGGCGGCAACTACAATTATCTGTAC

CGGCTGTTTAGAAAGTCTAATCTGAAGCCATTCGAGAGGGACATCTCCACAG

AAATCTACCAGGCCGGCTCTACCCCCTGCAATGGCGTGAAGGGCTTTAACTGT

TATTTCCCTCTGCAGAGCTACGGCTTCCAGCCAACATATGGCGTGGGCTATCA

GCCCTACCGCGTGGTGGTGCTGTCTTTTGAGCTGCTGCACGCACCTGCAACAG

T GTGCGGACC AA AGAAGAGC ACC AATCTGGT GAAGAAC AAGT GCGT GAACTT

CAAcggCTCTGGATCCGGCTACATCCCCGAGGCCCCCAGAGACGGCCAGGCCT

ACGTGCGGAAGGACGGCGAGTGGGTACTGctcagcaccttcctgggcAGCAGTTGGAA

AAGCTCCATCGCCTCCTTTTTCTTTATCATCGGCCTGATCATCGGACTGTTCCT

GGTGCTCCGCGTGGGTATCCACCTGTGCATCAAGCTGAAGCACACCAAGAAA

AGACAGATTTATACAGACATCGAGATGAACCGACTTGGAAAGTAAGCTAGCC

AGATTCTTCATGTTTGGACCAAATCAACTTGTGATACCATGCTCAAAGAGGCC

T C AATT AT ATTTGAGTTTTT AATTTTT AT GAAAA AAACT AAC AGC AAT CAT GG

AAGTCC ACGATTTTGAGACCGACGAGTTC AAT GATTT C AAT GAAGATGACT A

TGCCACAAGAGAATTCCTGAATCCCGATGAGCGCATGACGTACTTGAATCAT

GCTGATTACAATTTGAATTCTCCTCTAATTAGTGATGATATTGACAATTTGATC

AGGAAATTCAATTCTCTTCCGATTCCCTCGATGTGGGATAGTAAGAACTGGGA

TGGAGTTCTTGAGATGTTAACATCATGTCAAGCCAATCCCATCTCAACATCTC

AGAT GC AT A A AT GGAT GGGA AGTT GGTT AAT GT C T GAT AAT CAT GAT GC C AG

T C AAGGGT AT AGTTTTTT AC AT GAAGT GGAC AAAGAGGC AGAAAT AAC ATTT

GACGTGGTGGAGACCTTCATCCGCGGCTGGGGCAACAAACCAATTGAATACA

T C AAAAAGGAAAGAT GGACTGACTC ATTC AAAATTCTCGCTT ATTTGTGT C AA

AAGTTTTTGGACTTACACAAGTTGACATTAATCTTAAATGCTGTCTCTGAGGT GGAATTGCTCAACTTGGCGAGGACTTTCAAAGGCAAAGTCAGAAGAAGTTCT

CATGGAACGAACATATGCAGGATTAGGGTTCCCAGCTTGGGTCCTACTTTTAT

TTCAGAAGGATGGGCTTACTTCAAGAAACTTGATATTCTAATGGACCGAAAC

T TT C T GTT A AT GGT C A A AG AT GT GAT TAT AGGG AGG AT GCA A AC GGT GC T AT C

CATGGTATGTAGAATAGACAACCTGTTCTCAGAGCAAGACATCTTCTCCCTTC

T AAAT ATCT AC AGA ATT GGAGAT AAAATTGT GGAGAGGC AGGGAAATTTTTC

TTATGACTTGATTAAAATGGTGGAACCGATATGCAACTTGAAGCTGATGAAA

TTAGCAAGAGAATCAAGGCCTTTAGTCCCACAATTCCCTCATTTTGAAAATCA

TATCAAGACTTCTGTTGATGAAGGGGCAAAAATTGACCGAGGTATAAGATTC

CTCCATGATCAGATAATGAGTGTGAAAACAGTGGATCTCACACTGGTGATTT

AT GGAT C GTT C AG AC ATT GGGGT C ATCC TTTT AT AG ATT ATT AC AC T GGACT A

GAAAAATTACATTCCCAAGTAACCATGAAGAAAGATATTGATGTGTCATATG

CAAAAGCACTTGCAAGTGATTTAGCTCGGATTGTTCTATTTCAACAGTTCAAT

GATCATAAAAAGTGGTTCGTGAATGGAGACTTGCTCCCTCATGATCATCCCTT

T A A A AGT CAT GTT A A AGA A A AT AC AT GGCC C AC AGCTGC TC A AGTT C A AGAT

TTTGGAGATAAATGGCATGAACTTCCGCTGATTAAATGTTTTGAAATACCCGA

CTTACTAGACCCATCGATAATATACTCTGACAAAAGTCATTCAATGAATAGGT

CAGAGGTGTTGAAACATGTCCGAATGAATCCGAACACTCCTATCCCTAGTAA

AAAGGTGTTGCAGACTATGTTGGACACAAAGGCTACCAATTGGAAAGAATTT

CTT AAAGAGATT GAT GAG AAGGGCTT AGAT GATGATGATCT AATT ATTGGTCT

TAAAGGAAAGGAGAGGGAACTGAAGTTGGCAGGTAGATTTTTCTCCCTAATG

TCTTGGAAATTGCGAGAATACTTTGTAATTACCGAATATTTGATAAAGACTCA

TTTCGTCCCTATGTTTAAAGGCCTGACAATGGCGGACGATCTAACTGCAGTCA

TTAAAAAGATGTTAGATTCCTCATCCGGCCAAGGATTGAAGTCATATGAGGC

AATTTGCATAGCCAATCACATTGATTACGAAAAATGGAATAACCACCAAAGG

AAGTTATCAAACGGCCCAGTGTTCCGAGTTATGGGCCAGTTCTTAGGTTATCC

ATCCTTAATCGAGAGAACTCATGAATTTTTTGAGAAAAGTCTTATATACTACA

ATGGAAGACCAGACTTGATGCGTGTTCACAACAACACACTGATCAATTCAAC

CTCCCAACGAGTTTGTTGGCAAGGACAAGAGGGTGGACTGGAAGGTCTACGG

CAAAAAGGATGGACTATCCTCAATCTACTGGTTATTCAAAGAGAGGCTAAAA

T C AGA A AC AC T GCTGT C A A AGT CTT GGC AC A AGGT GAT A AT C A AGTT ATTT GC

AC AC AGT AT A A A ACGA AG A A AT C GAGA A AC GTT GT AGA ATT AC AGGGT GC T C

T C A AT C A A AT GGTTTCT A AT A AT GAGA A A ATT AT GAC T GCA AT C A A A AT AGG

GAC AGGG AAGTT AGG ACTTTT GAT AAAT GACGAT GAGACT AT GC AATCTGC A GATTACTTGAATTATGGAAAAATACCGATTTTCCGTGGAGTGATTAGAGGGTT

AG AG AC C A AG AG AT GGT C AC GAGT GACTTGT GT C AC C A AT GACC A A AT AC CC

ACTTGTGCTAATATAATGAGCTCAGTTTCCACAAATGCTCTCACCGTAGCTCA

TTTTGCTGAGAACCC AAT C AAT GCC ATGAT AC AGT AC A ATT ATTTT GGGAC AT

TTGCTAGACTCTTGTTGATGATGCATGATCCTGCTCTTCGTCAATCATTGTATG

AAGTTCAAGATAAGATACCGGGCTTGCACAGTTCTACTTTCAAATACGCCATG

TTGTATTTGGACCCTTCCATTGGAGGAGTGTCGGGCATGTCTTTGTCCAGGTTT

TTGATTAGAGCCTTCCCAGATCCCGTAACAGAAAGTCTCTCATTCTGGAGATT

CATCCATGTACATGCTCGAAGTGAGCATCTGAAGGAGATGAGTGCAGTATTT

GGAAACCCCGAGATAGCCAAGTTTCGAATAACTCACATAGACAAGCTAGTAG

AAGATCCAACCTCTCTGAACATCGCTATGGGAATGAGTCCAGCGAACTTGTT

AAAGACTGAGGTTAAAAAATGCTTAATCGAATCAAGACAAACCATCAGGAAC

CAGGTGATTAAGGATGCAACCATATATTTGTATCATGAAGAGGATCGGCTCA

GAAGTTTCTTATGGTCAATAAATCCTCTGTTCCCTAGATTTTTAAGTGAATTCA

AATCAGGCACTTTTTTGGGAGTCGCAGACGGGCTCATCAGTCTATTTCAAAAT

TCTCGTACTATTCGGAACTCCTTTAAGAAAAAGTATCATAGGGAATTGGATGA

TTTGATTGTGAGGAGTGAGGTATCCTCTTTGACACATTTAGGGAAACTTCATT

T GAGA AGGGGAT CAT GT A A A AT GT GGAC AT GTT C AGC T ACTC AT GCTGAC AC

ATTAAGATACAAATCCTGGGGCCGTACAGTTATTGGGACAACTGTACCCCAT

CCATTAGAAATGTTGGGTCCACAACATCGAAAAGAGACTCCTTGTGCACCAT

GTAACACATCAGGGTTCAATTATGTTTCTGTGCATTGTCCAGACGGGATCCAT

GACGTCTTTAGTTCACGGGGACCATTGCCTGCTTATCTAGGGTCTAAAACATC

TGAATCTACATCTATTTTGCAGCCTTGGGAAAGGGAAAGCAAAGTCCCACTG

ATTAAAAGAGCTACACGTCTTAGAGATGCTATCTCTTGGTTTGTTGAACCCGA

CTCTAAACTAGCAATGACTATACTTTCTAACATCCACTCTTTAACAGGCGAAG

AATGGACCAAAAGGCAGCATGGGTTCAAAAGAACAGGGTCTGCCCTTCATAG

GTTTTCGACATCTCGGATGAGCCATGGTGGGTTCGCATCTCAGAGCACTGCAG

C ATTGACC AGGTT GATGGC AACT AC AGAC ACC ATGAGGGATCTGGGAGAT C A

GAATTTCGACTTTTTATTCCAAGCAACGTTGCTCTATGCTCAAATTACCACCA

CTGTTGCAAGAGACGGATGGATCACCAGTTGTACAGATCATTATCATATTGCC

TGTAAGTCCTGTTTGAGACCCATAGAAGAGATCACCCTGGACTCAAGTATGG

ACTACACGCCCCCAGATGTATCCCATGTGCTGAAGACATGGAGGAATGGGGA

AGGTTCGTGGGGAC AAGAGAT AAAAC AGATCT ATCCTTT AGAAGGGAATTGG

AAGAATTTAGCACCTGCTGAGCAATCCTATCAAGTCGGCAGATGTATAGGTTT TCTATATGGAGACTTGGCGTATAGAAAATCTACTCATGCCGAGGACAGTTCTC

TATTTCCTCTATCTATACAAGGTCGTATTAGAGGTCGAGGTTTCTTAAAAGGG

TTGCT AGACGGATT AAT GAGAGC A AGTT GCTGCC AAGT AAT AC ACCGGAGAA

GTCTGGCTCATTTGAAGAGGCCGGCCAACGCAGTGTACGGAGGTTTGATTTA

CTTGATTGATAAATTGAGTGTATCACCTCCATTCCTTTCTCTTACTAGATCAGG

ACCTATTAGAGACGAATTAGAAACGATTCCCCACAAGATCCCAACCTCCTAT

CCGACAAGCAACCGTGATATGGGGGTGATTGTCAGAAATTACTTCAAATACC

AATGCCGTCTAATTGAAAAGGGAAAATACAGATCACATTATTCACAATTATG

GTTATTCTCAGATGTCTTATCCATAGACTTCATTGGACCATTCTCTATTTCCAC

CACCCTCTTGCAAATCCTATACAAGCCATTTTTATCTGGGAAAGATAAGAATG

AGTTGAGAGAGCTGGCAAATCTTTCTTCATTGCTAAGATCAGGAGAGGGGTG

GGA AGAC AT AC AT GT GA A ATTC TT C AC C A AGGAC AT ATT ATT GT GT C C AGAG

GAAAT C AG AC AT GCTTGC AAGTTCGGGATTGCT AAGGAT AAT A AT AAAGAC A

TGAGCTATCCCCCTTGGGGAAGGGAATCCAGAGGGACAATTACAACAATCCC

TGTTTATTATACGACCACCCCTTACCCAAAGATGCTAGAGATGCCTCCAAGAA

TCCAAAATCCCCTGCTGTCCGGAATCAGGTTGGGCCAATTACCAACTGGCGCT

CATTATAAAATTCGGAGTATATTACATGGAATGGGAATCCATTACAGGGACTT

CTTGAGTTGTGGAGACGGCTCCGGAGGGATGACTGCTGCATTACTACGAGAA

AATGTGCATAGCAGAGGAATATTCAATAGTCTGTTAGAATTATCAGGGTCAG

TCATGCGAGGCGCCTCTCCTGAGCCCCCCAGTGCCCTAGAAACTTTAGGAGG

AG AT A A AT C GAG AT GT GT A A AT GGT G A A AC AT GT T GGG A AT ATCCATCT G AC

TTATGTGACCCAAGGACTTGGGACTATTTCCTCCGACTCAAAGCAGGCTTGGG

GCTTCAAATTGATTTAATTGTAATGGATATGGAAGTTCGGGATTCTTCTACTA

GCCTGAAAATTGAGACGAATGTTAGAAATTATGTGCACCGGATTTTGGATGA

GC A AGGAGTTTT AATCT AC AAGACTT AT GGAAC AT AT ATTTGT GAGAGC GAA

A AG A AT GC AGT A AC A AT C CTT GGTCC C AT GTT C A AGAC GGTCGAC TT AGTT C A

AACAGAATTTAGTAGTTCTCAAACGTCTGAAGTATATATGGTATGTAAAGGTT

TGAAGAAATTAATCGATGAACCCAATCCCGATTGGTCTTCCATCAATGAATCC

TGGAAAAACCTGTACGCATTCCAGTCATCAGAACAGGAATTTGCCAGAGCAA

AGAAGGTTAGTACATACTTTACCTTGACAGGTATTCCCTCCCAATTCATTCCT

GATCCTTTTGTAAACATTGAGACTATGCTACAAATATTCGGAGTACCCACGGG

TGTGTCTCATGCGGCTGCCTTAAAATCATCTGATAGACCTGCAGATTTATTGA

CCATTAGCCTTTTTTATATGGCGATTATATCGTATTATAACATCAATCATATCA

GAGTAGGACCGATACCTCCGAACCCCCCATCAGATGGAATTGCACAAAATGT GGGGATCGCTATAACTGGTATAAGCTTTTGGCTGAGTTTGATGGAGAAAGAC

ATTCCACTATATCAACAGTGTTTAGCAGTTATCCAGCAATCATTCCCGATTAG

GT GGGAGGCTGTTTC AGT AAAAGGAGGAT AC AAGC AGAAGT GGAGT ACT AG

AGGTGATGGGCTCCCAAAAGATACCCGAACTTCAGACTCCTTGGCCCCAATC

GGGAACTGGATCAGATCTCTGGAATTGGTCCGAAACCAAGTTCGTCTAAATC

CATTCAATGAGATCTTGTTCAATCAGCTATGTCGTACAGTGGATAATCATTTG

AAAT GGT C AAATTT GCGAAGAAAC AC AGGAAT GATT GAAT GGATC AAT AGAC

GAATTTCAAAAGAAGACCGGTCTATACTGATGTTGAAGAGTGACCTACACGA

GGA A A AC TC TT GGAGAGATT A A A A A AT CAT GAGGAGACTCC A A AC TTT A AGT

ATGAAAAAAACTTTGATCCTTAAGACCCTCTTGTGGTTTTTATTTTTTATCTGG

TTTTGTGGTCTTCGT.

In another aspect, the invention provides an isolated nucleic acid encoding a recombinant fusion protein comprising (a) a glycoprotein (G) of a virus or a portion thereof, and (b) a SARS-CoV-2 spike protein (S) or a portion thereof. In some embodiments, the virus is a rhabdovirus. In some embodiments, the virus is a rabies virus or a vesicular stomatitis virus (VSV). In a particular embodiment, the virus is a rabies virus.

In one embodiment, the portion of the SARS-CoV-2 spike protein (S) is a receptor binding site of the SARS-CoV-2 spike protein (S). In another embodiment, the portion of the SARS-CoV-2 spike protein (S) is the SI domain. In another embodiment, the portion of the SARS-CoV-2 spike protein (S) is the N-terminal 750 amino acids of the SARS- CoV-2 spike protein (S).

In some embodiments, the glycoprotein (G) comprises a mutation substituting arginine with glutamic acid at position 333. In some embodiments, the portion of glycoprotein (G) comprises an ectodomain, a cytoplasmic domain, and a transmembrane domain. In some embodiments, the portion of the glycoprotein (G) comprises 31 amino acids of the ectodomain. In some embodiments, the glycoprotein (G) comprises 31 amino acids of the ectodomain and the full-length cytoplasmic domain.

In some embodiments, the sequence encoding the SARS-CoV-2 spike protein (S) or portion thereof is codon-optimized for expression in a human cell. In some embodiments, the sequence encoding the the SARS-CoV-2 spike protein (S) or portion thereof fused to a glycoprotein (G) or portion thereof is codon-optimized for expression in a human cell. In some embodiments, the recombinant fusion protein comprises the sequence of the SI domain of the SARS-CoV-2 spike protein (S) fused to a rabies glycoprotein (G) or portion thereof, shown as element “WuSl-RABVG” in “BNSP333-COVID19-S1-RVG” in FIG 18. In some embodiments, the recombinant fusion protein comprises the sequence of the SI domain of the SARS-CoV-2 spike protein (S) fused to a VSV glycoprotein (G) or portion thereof, shown as element “WuhanS-coVSV-G-tail” in “VSV-COVID19-S1- VSVG” in FIG 17.

In other aspects, the present invention provides nucleic acid molecules having double-stranded, single-stranded, and/or combinations of double- and single-stranded regions as well as full or partial complements of any of the sequences of the present disclosure.

In some aspects, the present disclosure provides the following sequences, or complements thereof:

Pharmaceutical Compositions and Formulations.

The vaccine of the invention may be formulated as a pharmaceutical composition. In some embodiments, the vaccine contains a live virus. In some embodiments, the vaccine contains deactivated viral particles in some embodiments, the virus is a recombinant virus encoded by any one of the nucleic acid constructs as described herein.

Such a pharmaceutical composition may be in a form suitable for administration to a subject (i.e. mammal), or the pharmaceutical composition may further comprise one or more pharmaceutically acceptable carriers, one or more additional ingredients, or some combination of these. The various components of the pharmaceutical composition may be present in the form of a physiologically acceptable salt, such as in combination with a physiologically acceptable cation or anion, as is well known in the art.

In one embodiment, the pharmaceutical compositions useful for practicing the method of the invention may comprise an adjuvant. Non-limiting examples of suitable adjuvants are Freund’s complete adjuvant, Freund’s incomplete adjuvant, Quil A, Detox, ISCOMs or squalene. In one embodiment, the adjuvant is an ADVAX™ adjuvant. In another embodiment, the adjuvant comprises Sepivac SWE™ adjuvant. In another embodiment, the adjuvant is monophosphoryl Lipid A (MPLA) (PFLAD®) in squalene.

In one embodiment, the adjuvant is MPLA 3D(6-acyl) PHAD® in 2% squalene. In one embodiment, the adjuvant increases or induces a Th-1 type immune response. The pharmaceutical composition or vaccine composition can comprise any one or more of the adjuvants described herein.

In some embodiments, the adjuvant comprises inulin e.g., delta inulin (e.g, delta inulin manufactured under current Good Manufacturing Practices is referred to in the art as Advax).

In one embodiment, the adjuvant comprises a delta inulin polysaccharide formulated with the TLR9 agonist (e.g, CpG oligodeoxynucleotides (CpG ODN)). In some embodiments, the adjuvant is Advax-SM™ (Vaxine Pty Ltd, Bedford Park, Australia). In some embodiments, the adjuvant comprises a mixture of an oil component and a surfactant component.

In one embodiment, the composition may be an oil/surf actant dispersion or an oil/surf actant solution.

In other embodiments, the adjuvant comprises an emulsion e.g., an oil in water (o/w) emulsion.

In one embodiment, the composition includes an oil component which is formed from one or more oil(s).

In another embodiment, the oil(s) and the surfactant(s) in the composition are metabolizable (biodegradable) and biocompatible.

In some embodiments, the composition further comprises component(s) in addition to the oil and surfactant components.

In other embodiments, the proportions of the oil component and the surfactant component can vary. In some embodiments, an oil-in-water emulsion comprises oil droplets (e.g, submicron oil droplets as determined by e.g, dynamic light scattering (DLS)) when mixed with a volume of an aqueous material (e.g, water). In other embodiments, the oil droplets have an average diameter of less than about 300 nm when mixed with a volume of an aqueous material (e.g, water), illustratively, about 50 to about 290 nm, about 60 to about 280 nm, about 70 to about 270 nm, about 80 to about 260 nm, about 90 to about 250 nm, about 100 to about 240 nm, about 110 to about 230 nm, about 120 to about 220 nm, about 130 to about 210 nm, and about 140 to about 200 nm. In some embodiments, the oil droplets have an average diameter of about 160 nm (e.g, 160 ± 10 nm), about 155 nm (e.g, 155 ± 10 nm), about 142 nm (e.g, 142 ± 5 nm), about 120 nm (e.g, 120 ± 40 nm), or about 100 nm (e.g, 10 ± 20 nm). In some embodiments, the oil droplets have an average diameter of about 142 nm (e.g, 142 ± 5 nm).

In one embodiment, the total oil component is about 50% to about 90% by volume of the adjuvant composition. In another embodiment, the total oil component is no more than about 50%, no more than about 55%, no more than about 60%, no more than about 65%, no more than about 70%, no more than about 75%, no more than about 80%, no more than about 85%, or no more than about 90% by volume of the adjuvant composition.

In some embodiments, the oil comprises a terpenoid (e.g, a branched, unsaturated terpenoid).

In one embodiment, the oil comprises squalene. In another embodiment, the oil comprises a saturated analog to squalene. In one embodiment, saturated analog to squalene is squalane.

In one embodiment, the adjuvant comprises a squalene oil in water emulsion. In another embodiment, the squalene in water emulsion comprises one or more non-ionic surfactants and/or other oils and/or stabilizers.

In other embodiments, the adjuvant comprises about 7 mgs to about 13 mgs, about 8 mgs to about 12 mgs, about 8 mgs to about 11 mgs, about 9 mgs to about 10 mgs, about 9.5 mgs to about 9.75 mgs of squalene ( e.g ., (mgs of squalene per 0.25 ml) or in 0.5 ml vaccine dose)). In one embodiment, the adjuvant comprises about 8.6 mgs, 9.75 mgs, 10.75 mgs, or 12.5 mgs of squalene.

In another embodiment, the adjuvant is a squalene in water emulsion comprising about 7 to about 13 mgs of squalene (e.g., (mgs of squalene per 0.25 ml) or in 0.5 ml vaccine dose)), illustratively, about 7 to about 13 mgs, about 8 to about 12 mgs, about 8 to about 11 mgs, about 9 to about 10 mgs, about 9.5 to about 9.75 mgs of squalene (e.g, (mgs per 0.25 ml) or in 0.5 ml vaccine dose)). In one embodiment, the adjuvant is a squalene in water emulsion comprising about 9.75 mgs of squalene (e.g, (mgs of squalene per 0.25 ml) or in 0.5 ml vaccine dose)).

In other embodiments, the oil component comprises one or more tocopherols (e.g, a, b, g, d, e, x tocopherol). In one embodiment, the tocopherol is D- a-tocopherol and/or DL- a-tocopherol. In another embodiment, the a-tocopherol is DL-a-tocopherol. In other embodiments, the oil component of the adjuvant is an oil combination comprising squalene and a tocopherol (e.g. DL-a-tocopherol).

In some embodiments, the surfactant component comprises an ionic, a non-ionic, or a zwitterionic surfactant, and any combination thereof. In one embodiment, the surfactant component comprises only non-ionic surfactant(s).

Examples of surfactants include, but are not limited to, the polyoxyethylene sorbitan esters surfactants (e.g, Tweens, polysorbates, such as, e.g, polysorbate 80 (e.g, Tween™ 80), copolymers of ethylene oxide, propylene oxide, butylene oxide), sorbitan esters (e.g, sorbitan trioleate (e.g, Span™ 85), sorbitan monolaurate), and polyoxyethylene lauryl ether (e.g, Emulgen 104P), octoxynols (e.g, Triton X-100, IGEPAL CA-630/NP-40), phospholipids (e.g, lecithin), and Brij surfactants (e.g, polyoxyl 4 lauryl ether (Brij 30)).

In some embodiments, the surfactant in the composition (% by volume of the oil/surfactant composition) is no more than about: 49%, 48%, 47%, 46%, 45%, 44%, 43%, 42%, 41%, 40%, 39%, 38%, 37%, 36%, 35%, 34%, 33%, 32%, 31%, 30%, 29%, 28%, 27%, 26%, 25%, 24%, 23%, 22%, 21%, 20%, 19%, 18%, 17%, 16%, 15%, 14%, 13%, 12%, 11%, or 10%.

In one embodiment, the surfactant component consists of a mixture of polysorbate 80 ( e.g ., Tween™ 80) and sorbitan trioleate (e.g, Span™ 85). In another embodiment, the surfactant component consists of a mixture of polysorbate 80 (e.g, Tween™ 80) and sorbitan trioleate (e.g, Span™ 85) in a volume ratio having more sorbitan trioleate (e.g, Span™ 85) than polysorbate 80 (e.g, Tween™ 80). In some embodiments, the surfactant component consists of a mixture of polysorbate 80 (e.g., Tween™ 80) and sorbitan trioleate (e.g, Span™ 85) in a volume ratio that achieves a HLB of about 8. In some embodiments, the surfactant component consists of a mixture (e.g, (mgs of squalene per 0.25 ml) or in 0.5 ml vaccine dose)) of about 1.175 mgs polysorbate 80 (e.g, Tween™

80) and about 1.175 mgs sorbitan trioleate (e.g, Span™ 85).

In other embodiments, the aqueous component (e.g, water) further comprises one or more components e.g. solutes/salts/buffers. In one embodiment, the salts (e.g, sodium salts) form a pH buffer (e.g. citrate, phosphate). In another embodiments, one or more buffers include, but are not limited to, a citrate buffer, phosphate buffer (e.g., phosphate buffered saline, ammonium phosphate), a Tris buffer, a borate buffer, a succinate buffer, or a histidine buffer. In some embodiment, a buffered aqueous component comprises about 1 to about 20 mM of total buffer.

In other embodiments, the pH of the aqueous component is buffered at about pH 5.5 to about pH 8.0, illustratively, about pH 6.1 to about pH 7.9, about pH 6.2 to about pH 7.8, about pH 6.3 to about pH 7.7, about pH 6.4 to about pH 7.6, about pH 6.5 to about pH 7.5, about pH 6.6 to about pH 7.4, about pH 6.7 to about pH 7.3, about pH 6.8 to about pH 7.2, and about pH 6.9 to about pH 7.1. In one embodiment, the pH of the aqueous component is buffered at about pH: 5.7, 6.0, 6.5, 6.8, or 7.2. In another embodiment, the pH of the aqueous component is buffered at about pH 6.0 to about pH 6.5. In other embodiments, the buffer is 10 mM citrate buffer with a pH of about 6.5.

In other embodiments, the adjuvant is a squalene in water emulsion comprising (e.g, (mgs of squalene per 0.25 ml) or in 0.5 ml vaccine dose)) about 9.75 mgs squalene, 1.175 mgs polysorbate 80 (e.g, Tween™ 80), 1.175 mgs sorbitan trioleate (e.g, Span™ 85), citrate buffer, and a pH of about 6.5.

In some embodiments, an adjuvant of the present disclosure is co-formulated or co-administered with the vaccine. In other embodiments, an adjuvant of the present disclosure is not co-formulated or co-administered with the vaccine.

Pharmaceutical compositions that are useful in the methods of the invention may be suitably developed for inhalation, oral, rectal, vaginal, parenteral, topical, transdermal, pulmonary, intranasal, buccal, ophthalmic, intrathecal, intravenous or another route of administration. Other contemplated formulations include projected nanoparticles, liposomal preparations, resealed erythrocytes containing the active ingredient, and immunologically-based formulations. The route(s) of administration is readily apparent to the skilled artisan and depends upon any number of factors including the type and severity of the disease being treated, the type and age of the veterinary or human patient being treated, and the like.

Although the descriptions of pharmaceutical compositions provided herein are principally directed to pharmaceutical compositions suitable for ethical administration to humans, it is understood by the skilled artisan that such compositions are generally suitable for administration to animals of all sorts. Modification of pharmaceutical compositions suitable for administration to humans in order to render the compositions suitable for administration to various animals is well understood, and the ordinarily skilled veterinary pharmacologist can design and perform such modification with merely ordinary, if any, experimentation.

The composition of the invention may comprise a preservative from about 0.005% to 2.0% by total weight of the composition. The preservative is used to prevent spoilage in the case of exposure to contaminants in the environment.

Administration/Dosing

The regimen of administration of the compositions of the present invention may affect what constitutes an effective amount. For example, the vaccines, polypeptides, and/or the nucleic acids of the invention may be administered to the subject (i.e. mammal) in a single dose, in several divided dosages, as well as staggered dosages may be administered daily or sequentially, or the dose may be continuously infused, or may be a bolus injection. Further, the dosages may be proportionally increased or decreased as indicated by the exigencies of the therapeutic or prophylactic situation.

Administration of the compositions of the present invention to a subject, preferably a mammal, more preferably a human, may be carried out using known procedures, at dosages and for periods of time effective to treat the disease in the subject. An effective amount of the composition necessary to achieve the intended result will vary and will depend on factors such as the disease to be treated or prevented, the age, sex, weight, condition, general health and prior medical history of the subject being treated, and like factors well-known in the medical arts. In particular embodiments, it is especially advantageous to formulate the composition in dosage unit form for ease of administration and uniformity of dosage. Dosage unit form as used herein refers to physically discrete units suited as unitary dosages for the subjects to be treated; each unit containing a predetermined quantity of therapeutic compound calculated to produce the desired therapeutic effect in association with the required pharmaceutical vehicle. The dosage unit forms of the invention are dictated by and directly dependent on (a) the unique characteristics of the composition and the heterologous protein to be expressed, and the particular therapeutic effect to be achieved.

In some embodiments, the vaccine administered may be in an amount that will depend e.g., on the subject to be treated, the capacity of the subject's immune system to develop the desired immune response, and/or the degree of protection desired.

In other embodiments, the administration of the vaccines of the present invention can be in accordance with any suitable vaccination schedule, e.g, day 0, one month, four months, and twelve months from day 0. In other embodiments, the vaccines described herein may also be given in a single dose schedule, or a multiple dose schedule in which a primary course of vaccination may be with 1-10 separate doses, followed by other doses given at subsequent time intervals required to maintain and/or reinforce the immune response, for example, at 1-4 months for a second dose, and if needed, a subsequent dose(s) after several months. In some embodiment, other examples of suitable immunization schedules include, but are not limited to: (i) 0, 1 month and 6 months, (ii)

0, 7 days and 1 month, (iii) 0 and 1 month, (iv) 0 and 6 months, (v) 0, 1 month and 2 months, or other schedules sufficient to elicit the desired immune responses expected to confer protective immunity, and/or reduce disease symptoms, or reduce severity of disease.

In one embodiment, the administration of the vaccines of the present can be in accordance with any suitable vaccination schedule and/or dosage(s) effective to produce an antigen-specific immune response. In some embodiments, an antigen-specific immune response comprises a B and/or T cell response. In other embodiments, the antigen- specific immune response comprises administration of a single dose (no booster dose). In some embodiments, a second (booster) dose of the vaccine may be administered. In other embodiments, additional doses may be administered.

In some embodiments, the administration of the vaccines of the present can be in accordance with any suitable vaccination schedule and/or dosage(s) effective such that the subjects exhibit a seroconversion rate of at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, or at least 95% following the first dose or the second (booster) dose of the vaccine.

In other embodiments, the administration of the vaccines of the present can be in accordance with any suitable vaccination schedule and/or dosage(s) effective to produce an antigen-specific immune response in the subject, wherein the anti-antigen antibody titer produced in the subject is increased by at least 1 log relative to a control.

In some embodiments, the control is an anti-antigen antibody titer produced in a subject who has not been administered a vaccine of the present disclosure. In other embodiments, the control is a titer produced in a subject that has been administered a live attenuated or inactivated vaccine; a recombinant or purified protein vaccine; or a virus like particle vaccine.

In one embodiment, the titer produced in the subject is increased by 1-3 log relative to the control. In another embodiment, the titer produced in a subject is increased at least 2 times relative to the control. In other embodiments, the titer produced in the subject is increased at least 3, 4, 5, 10 or more times relative to the control. In one embodiment, the titer produced in the subject is increased at least 10 times relative to a control. In another embodiment, the titer produced in the subject is increased 2-10 times relative to a control.

In some embodiments, the vaccine of the present disclosure is administered to a subject in an effective amount ( e.g an amount effective to induce an immune response). In some embodiments, the effective amount is a dose equivalent to an at least 2-fold, at least 4-fold, at least 10-fold, at least 100-fold, at least 1000-fold reduction in the standard of care dose of a recombinant protein vaccine, wherein the anti-antigen antibody titer produced in the subject is equivalent to an anti-antigen antibody titer produced in a control subject administered the standard of care dose of a recombinant protein vaccine, a purified protein vaccine, a live attenuated vaccine, an inactivated vaccine, or a VLP vaccine. In some embodiments, the effective amount is a dose equivalent to 2- 1000-fold reduction in the standard of care dose of a recombinant protein vaccine, a purified protein vaccine, a live attenuated vaccine, an inactivated vaccine, or a VLP vaccine. In other embodiments, the effective amount of the vaccine administered comprises a total dose of about 0.1 pg to about 1000 pg of the vaccine or active ingredient (e.g,

VLP, virion, viral vector, antigen, or nucleic acid molecule), illustratively, about 1 pg to about 900 pg, about 5 pg to about 700 pg, about 10 pg to about 500 pg, about 15 pg to about 300 pg, about 20 pg to about 200 pg, and about 25 pg to about 100 pg, In some embodiments, the effective amount is a total dose of about 25 pg, about 50 pg, or about 100 pg. In other embodiments, the effective amount is a total dose of not less than (NLT) about 1 pg, about 5 pg, about 10 pg, about 15 pg, about 20 pg, about 25 pg, about 30 pg, about 35 pg, about 40pg, about 45 pg, about 50 pg, about 55 pg, about 60 pg, about 65 pg, about 70 pg, about 75 pg, about 80 pg, about 85 pg, about 90 pg, about 95 pg, or about 100 pg. In other embodiments, the effective amount is a total dose of about 0.1 pg to about 10 pg.

In some embodiments, doses of the vaccine are based on quantification of DNase- resistant particles (DRPs). In one embodiment, DRPs are equivalent to encapsidated vector genomes. In some embodiments, the subject receives at least one dose (e.g, a first dose at time zero) of the vaccine of about 10⁵ to 10²⁰ about DRPs, illustratively, about 10⁶ to 10¹⁸, about 10⁷ to 10¹⁷, about 10⁸ to 10¹⁶, about 10⁹ to 10¹⁵, about 10¹⁰ to 10¹⁴, and about 10¹¹ to 10¹³ DRPS. In other embodiments, the subject receives at least one dose (e.g, a first does at time zero) of at least about 10⁵, at least about 10⁶, at least about 10⁷, at least about 10⁸, at least about 10⁹, at least about 10¹⁰, at least about 10¹¹, at least about 10¹², at least about 10¹³, at least about 10¹⁴, at least about 10¹⁵, at least about 10¹⁶, at least about 10¹⁷, at least about 10¹⁸, at least about 10¹⁹, or at least about 10²⁰ DRPs.

In some embodiments, the effective amount is a dose administered to the subject a total of one, two, three, four, five, or more times.

In some embodiments, the efficacy or effectiveness of a vaccine of the present disclosure is equal to or greater than about 60%. Vaccine efficacy or effectiveness may be assessed using e.g, standard analyses and protocols known in the art. In one embodiment, the efficacy or effectiveness of the vaccine is at least about 60%, at least about 65%, at least about 70%, at least about 75%, at least about 80%, at least about 85%, or at least about 90%.

In some embodiments, the vaccine immunizes the subject against a coronavirus (e.g, SARS-CoV-2 virus) for up to 6 months, 1 year or 2 years. In some embodiments, the vaccine immunizes the subject against a coronavirus (e.g, SARS-CoV-2 virus) for at least about 6 months, at least about 1 year, at least about 2 years, at least about 3 years, at least about 4 years, or about 5 years to about 10 years, or more.

Routes of Administration

One skilled in the art will recognize that although more than one route can be used for administration, a particular route can provide a more immediate and more effective reaction than another route. Routes of administration of any of the compositions of the invention include inhalation, oral, nasal, rectal, parenteral, sublingual, transdermal, transmucosal (e.g., sublingual, lingual, (trans)buccal, (trans)urethral, vaginal (e.g., trans- and perivaginally), (intra)nasal, and (trans)rectal), intravesical, intrapulmonary, intraduodenal, intragastrical, intrathecal, subcutaneous, intramuscular, intradermal, intra arterial, intravenous, intrabronchial, inhalation, electroporation and topical administration.

Kits

In some embodiments a kit is provided for treating, preventing, or ameliorating an a given disease, disorder or condition, or a symptom thereof, as described herein wherein the kit comprises: a) a compound or compositions as described herein; and optionally b) an additional agent or therapy as described herein. The kit can further include instructions or a label for using the kit to treat, prevent, or ameliorate the disease, disorder or condition. In yet other embodiments, the invention extends to kits assays for a given disease, disorder or condition, or a symptom thereof, as described herein. Such kits may, for example, contain the reagents from PCR or other nucleic acid hybridization technology (microarrays) or reagents for immunologically based detection techniques (e.g., ELISpot, ELISA).

Methods of Treatment

In one aspect, the invention includes a method of generating an immune response against a SARS-CoV-2 virus in a subject in need thereof. In another aspect, a method of vaccinating a subject against a SARS-CoV-2 virus is provided. In yet another aspect, a method of providing immunity against a SARS-CoV-2 virus in a subject is provided. In still another aspect, a method of treating and/or preventing a disease or disorder associated with SARS-CoV-2 virus in a subject in need thereof. In some embodiments, the method comprises administering to the subject an effective amount of a recombinant virus as described herein. In some embodiments, the method comprises administering to the subject an effective amount of a vaccine described herein. In some embodiments, the disease or disorder associated with the SARS-CoV-2 virus is a respiratory disease. In some embodiments, the disease or disorder associated with the SARS-CoV-2 virus is coronavirus disease. In some embodiments, the disease or disorder associated with the SARS-CoV-2 virus is COVID-19.

Pharmaceutical compositions comprising the vaccine of the present invention may be administered in a manner appropriate to the disease to be treated (or prevented). The quantity and frequency of administration will be determined by such factors as the condition of the patient, and the type and severity of the patient’s disease, although appropriate dosages may be determined by clinical trials.

The administration of the vaccine of the invention may be carried out in any convenient manner known to those of skill in the art. The vaccine of the present invention may be administered to a subject by aerosol inhalation, injection, ingestion, transfusion, implantation or transplantation. The compositions described herein may be administered to a patient transarterially, subcutaneously, intradermally, intratumorally, intranodally, intramedullary, intramuscularly, by intravenous (z.v.) injection, or intraperitoneally.

Subjects to which administration of the pharmaceutical compositions of the invention is contemplated include, but are not limited to, humans and other primates, mammals, and birds, including commercially relevant mammals and birds such as cattle, pigs, horses, sheep, chicken, ducks, cats, dogs, and ferrets.

In some embodiments, the subject is a domesticated animal. In some embodiments, the subject is a domestic pet. In some embodiments, the animal is a captive animal, e.g., an animal maintained in an exhibit or in a zoological park. In some embodiments, the animal is livestock. In some embodiments, the subject is an animal susceptible to infection with SARS-CoV-2 and can be a reservoir for the SARS-CoV-2 virus. In some embodiments, the subject is a feline. In some other embodiments, the subject is a canine. In some embodiments, the subject is a member of the Mustelidae family, such as a weasel, polecat, stoat, marten, mink, badger, otter, or ferret. In some embodiments, the subject is a cat. In some other embodiments, the subject is a dog. In some embodiments, the subject is a ferret.

In one aspect, a method of preventing SARS-CoV-2 infection or providing immunity to SARS-CoV-2 in a subject is provided, the method comprising administering to a subject a SARS-CoV-2 vaccine described herein, wherein the subject is a domestic pet selected from a cat, a dog, and a ferret. In particular, felines and ferrets have been identified as a potential host for SARS-CoV-2 (J. Shi etal. , Science 10.1126/science. abb7015 (2020)). Cats are one of the most favored pets of the USA's citizens. In the United States, one in three households owns a pet cat, with an average of 2.2 cats per cat-owning household. However, pet cats are only a part of the total cat population in the country, which is estimated to be around 76.5 million.

Currently, rabies vaccination is recommended for cats, dogs, and ferrets. CDC guidelines recommend that all dogs, cats, and ferrets should be vaccinated and revaccinated against rabies according to product label directions (www.cdc.gov/rabies/ specific groups/ veterinarians/vaccination. html). If a previously vaccinated animal is overdue for a booster, it should be revaccinated. Immediately following the booster, the animal is considered currently vaccinated and should be placed on a vaccination schedule according to the labeled duration of the vaccine used.

The existing RABV vaccine for cats, dogs, or ferrets can be replaced with a rabies virus-based SARS-CoV-2 vaccine to induce protection from both diseases. Thus, in one aspect, a method of providing immunity to rabies and a SARS-CoV-2 associated disease in a subject is provided, wherein the subject is a cat, dog, or ferret. The method includes the step of administering to the subject a vaccine comprising a rabies virus-based SARS- CoV-2 vaccine. In another aspect, a vaccine for cats, dogs, or ferrets is provided, the vaccine comprising a rabies virus-based SARS-CoV-2 vaccine. In some embodiments, the vaccine comprises a recombinant rabies virus comprising a SARS-CoV-2 spike protein (S) or a portion thereof. In some embodiments, the vaccine comprises a recombinant rabies virus comprising a fusion of (a) a glycoprotein (G) of a virus or a portion thereof, and (b) a SARS-CoV-2 spike protein (S) or a portion thereof. In some embodiments, the vaccine comprises an inactivated virus. In particular embodiments, the vaccine comprises an adjuvant. In some embodiments, the vaccine is formulated for administration to a cat. In some other embodiments, the vaccine is formulated for administration to a dog. In still other embodiments, the vaccine is formulated for administration to a ferret.

It should be understood that the method and compositions that would be useful in the present invention are not limited to the particular formulations set forth in the examples. The following examples are put forth so as to provide those of ordinary skill in the art with a complete disclosure and description of how to make and use the cells, expansion and culture methods, and therapeutic methods of the invention, and are not intended to limit the scope of what the inventors regard as their invention. The practice of the present invention employs, unless otherwise indicated, conventional techniques of molecular biology (including recombinant techniques), microbiology, cell biology, biochemistry and immunology, which are well within the purview of the skilled artisan. Such techniques are explained fully in the literature, such as, “Molecular Cloning: A Laboratory Manual”, fourth edition (Green, M. R. & Sambrook, L, Cold Spring Harbor Laboratory Press, 2012); “Oligonucleotide Synthesis, a practical approach” (PaselkR. A., edited by Gait, M. L, IRL Press, Oxford, 1984); “Culture of Animal Cells: A Manual of Basic Technique and Specialized Applications, Sixth Edition” (Freshney, R. L, John Wiley & Sons, Inc., 2010); “Methods in Enzymology” (Vol. 152, Guide to Molecular Cloning Techniques, Berger and Kimmel, Eds., San Diego: Academic Press, Inc., 1987); “Handbook of Experimental Immunology” (Herzenberg L.A., Weir, D.M., Blackwell, C., Wiley, 1997); “Gene Transfer Vectors for Mammalian Cells” (Miller and Calos, eds., Cold Spring Harbor Laboratory, Cold Spring Harbor, 1987); “Short Protocols in Molecular Biology” (Ausubel, F. M., et al ., ed., John Wiley & Sons, 2002); “Polymerase Chain Reaction: Principles, Applications and Troubleshooting” (Babar, M. E., publisher VDM Verlag Dr. Miiller, 2011); “Current Protocols in Immunology” (Colligan, J. E., et al ., ed., Greene Pub. Associates and Wiley- Interscience, 2002). These techniques are applicable to the production of the polynucleotides and polypeptides of the invention, and, as such, may be considered in making and practicing the invention. Particularly useful techniques for particular embodiments will be discussed in the sections that follow.

EXPERIMENTAL EXAMPLES

The invention is now described with reference to the following Examples. These Examples are provided for the purpose of illustration only, and the invention is not limited to these Examples, but rather encompasses all variations that are evident as a result of the teachings provided herein.

Example 1

RABV, VSV, and MV expressing Covid S or Covid-Sl

The materials and methods employed in Examples 1-5 are now described. Generation of RABV-. VSV-. and MV- based vaccines against COVID-19 The SARS-CoV-2 spike protein (S) was used in generating the vaccines against COVID- 19 described herein. SARS-CoV-2 causes Convid-19. The SI domain (receptor binding site of the S protein) was incorporated into the Genome of rabies virus (RABV) and vesicular stomatitis virus (VSV). For both constructs part of their native G protein was used to promote the incorporation of the SI domain. The full-length SARS-CoV-2 S was found to interfere with viral growth (VSV or RABV G) making it almost impossible to produce the vaccine; thus the SI domain was used instead.

Three measles virus (MV)-based vaccine expressing full-length SARS-CoV-2 spike protein (S) were also prepared. These three viruses express the SARS-CoV-2 spike protein (S) from position 2, 3, or 6 of the genome. Previous research indicates that for measles virus the position a foreign gene is expressed is important for MV replication and immunogenicity of the trans-gene. However this depends on the antigen, so three different viruses were prepared.

Testing of RABV-. VSV-. and MV- based vaccines against COVID-19 in animals

In the next phase, the vaccines are tested in animals. The receptor for both viruses is believed to be ACE 2. The model that will be used is a hamster or mice (transgenic expressing ACE2 or wildtype infected with an Adenovirus expressing ACE2).

Both live and killed viruses are tested. After immunization mice or hamster are challenged with the SAR.S-CoV-2 (Convid-19).

Immunological parameters of the 2019-nCoV vaccine.

The parameters of the induced humoral and cellular immune responses will be studied after i.m. inoculation of mice (including 2019-nCoV challenge), and non-human primate (NHP) (immunogenicity). ELISA and virus neutralization assays (VNA) will be utilized to analyze the humoral immune response. These assays are developed for mice and NHP and, based on the limited space, only briefly described below. Previous experience will be used in the development of such assays especially in the field of coronaviruses ELISA assay for detection of 2019-nCoV SI and vector RABV G-specific humoral responses.

Preparation of highly purified antigens against 2019-nCoV SI or RABV G. Purification of the HA-tagged soluble protein from the supernatant of transfected 293 T cells is carried out as described previously for MERS-CoV (17). Purified proteins can be prepared in the mg range sufficient for large numbers of assay plates. Approximately 10- 20 mg of purified RABV G is produced on a regular basis in the Schnell laboratory.

To determine antibody responses to the 2019-nCoV S or RABV G, an indirect ELISA will be developed utilizing purified S 1 or G protein (26) and unpublished. Sera from vaccinated mice or NHP will be used at different dilutions to determine the EC50 over time. Serum IgM and IgG antibodies (total IgM, IgG, IgGl, IgG2 for NHP, IgG2c and IgGl for B6) to each vaccine antigen will be measured by a qualified ELISA that is well established in the Thomas Jefferson University (TJU) laboratories. Prior to performing the ELISA assays, we will qualify the assay for each vaccine antigen. Our ELISA platform will be standardized to measure serum IgG specific for the vaccine antigens by characterizing assay variability, determining the limit of quantitation, defining the positive and negative quality control ranges, and defining assay acceptance criteria. TJU has substantial experience in qualifying and performing ELISA assays using this platform and plan to use it for future clinical studies as well. Assays will be transferred for the human clinical samples to a contractor via IQ VIA.

Virus Neutralization assays (VNA) for RABV are well established in the TJU laboratory (12, 27, 28) for mouse, monkey, and human sera. Use of an internal WHO standard, allows determining the international unit (I.U.) achieved by the immunization. The presence of 0.5 I.U or more in the sera is considered a correlate of protection from rabies. VNA for MERS-CoV are established at the University of Maryland in the Frieman lab. Dr. Frieman has a virus sample from CDC from the Washington St patient. He is also recreating multiple strains using his infectious clone and synthesizing full genomes. Cellular responses

Most likely, humoral responses are the key for protection based on previous studies of coronaviruses but as a research part, frequencies and cytokine expression profiles of vaccine antigen-specific T cells will be measured in splenocytes or cryopreserved NHP PBMCs using a qualified 13-color ICS assay. In order to assess potential for durable antibody responses, antigen specific IgG⁺ ELISPOT analysis will be performed to detect antibody-secreting plasma cells in the bone marrow 28 days post-boost immunization.

The results of the experiments are now described.

RABV, VSV, and MV expressing Covid S or Covid-Sl

VS V expressing codon-optimized Covid-Sl, RABV expressing codon-optimized Covid-Sl, and MV expressing codon-optimized Covid-S from positions 2, 3, and 6 of the genome were generated (FIGS. l-5; FIGs. 17-21).

FIG. 6 shows characterization of RABV (RABV-COV19-S1) and VSV (VSV- COV19-S1) expressing a chimeric Sl-G fusion protein. SDS-PAGE analysis of purified virions after sucrose gradient purification. Letters indicate the positions of the VSV or RABV L, G, N, P, and M proteins. Numbers to the left indicate the sizes of the molecular mass standards. The Covid-19 SI protein is indicated. The controls show VSV and RABV virions.

Example 2

A rabies vaccine based bivalent vaccine against 2019-nCoV

Technologies developed for MERS-CoV and SARS-CoV can be transferred to the 2019-nCov. Most vaccine design has focused on the major immunodominant antigen, the Spike (S) protein located on the surface of the virion, which serves as the ligand for the MERS-CoV receptor dipeptidyl peptidase 4 (DPP4, also known as CD26) (1). Similar to MERS-CoV S 2019-nCoV S is a transmembrane glycoprotein that is likely cleaved by the furin protease into SI and S2 domains as MERS-CoV S (2). Without intending to be bound by theory, it is believed that, as for other coronaviruses such as MERS-CoV, virus neutralizing antibodies (VNA), which are produced in response to infection or vaccination with MERS-CoV S, will neutralize virus infection in vitro and protect lungs from infection in mouse models of disease (3-6).

Described herein is a Rhabdovirus-based vaccine that offers a combination of features that could prove desirable for an effective 2019-nCoV vaccine. Rhabdovirus- vectored vaccine candidates have been developed for several human pathogens (7). More recently both RABV and VSV have been successfully utilized as Ebola virus (EBOV) vaccines and both approaches are either close to clinical trials (RABV) or have already completed phase 2 clinical trials (VSV) (8, 9). Chemically inactivated RABV vaccines are widely used and safe for humans; approximately 100 million doses of inactivated RABV vaccines are administered to humans every year, demonstrating an excellent safety profile (10). Both live and chemically inactivated RABV vaccines are shown to be safe for animals. In a proof of concept study both live-attenuated as well as inactivated RABV-EBOV have been utilized successfully against EBOV and this vaccine enters a phase 1 clinical trial in 2020. (11-14).

Construction of an attenuated RABV 2019-CoV based on the well-characterized MERS- CoV vaccine (FIG. 12 and (15)).

The nucleotide sequence encoding 2019-nCoV SI protein was inserted into the CBNSP333 vector (FIG. 12; FIG. 18 “BN8R333 qnΐϋ19-81^nq”). 2019-nCoV S is a glycoprotein anchored in the membrane of the 2019-nCoV virions that projects from the surface of the virus to act as a ligand to susceptible cells, and is therefore a major immunogen. The BNSP333 vaccine vector utilized is derived from the attenuated RABV strain SAD-B19 (16). Several modifications were introduced into the parent strain to increase safety and maximize expression of foreign genes. It was previously shown that foreign genes can be stably introduced into this vector (14, 17-20). Moreover, it was shown that expression of foreign antigens from a position between the RABV N and P gene, as well as codon optimization for human cells of the target gene, results in the highest expression level of the foreign antigen (14). Additionally, replacing the arginine with glutamic acid at position 333 (333R->333E) within the RABV glycoprotein (G) further reduces the pathogenicity of the already highly attenuated vector (19). This improved vector was successfully used to generate candidate vaccines against several emerging zoonotic viral diseases like EBOV and Henipaviruses (14, 21). However, expression of full length CoV S was found to inhibit expression of RABV G protein and reduces viral titers dramatically. However, expression of SI fused to the C-terminal part of RABV G resulted in strong incorporation of RABV G-MERS-CoV-Sl fusion protein. The RABV G-2019-nCoV-Sl vaccine is similar to the MERS-CoV 331 -SI =

MERSRAB) expressing the N-terminal 750 aa of 2019-nCoV S fused to a truncated RABV glycoprotein, which comprises 31 aa of the ectodomain (ED) of RABV G and the complete CD and the transmembrane domain of RABV G to allow chimeric glycoprotein incorporation into RABV virions. The chimeric 2019-nCoV Sl/RABV G protein utilizes the original 2019-CoV ER translocation sequence (SS) and is generated by PCR of codon optimized cDNA fragments (FIG. 12).

All the following results are presented from previous studies with the MERS construct (MERSRAB). For MERSRAB, infectious virus was recovered. The new virus expressing the SI fragment grew to similar titers of roughly 108 FFU/mL as the control virus BNSP333 on Vero cells, which are approved for human vaccine production. The BNSP333 RABV expressing the SI was entitled MERSRAB and the animal efficacy studies listed below resulted from this constructs. The RABV-based MERSRAB vaccine proved efficacious in three different animal models: mice transduced with an Ad5 virus expressing human hDPP4 (the receptor for MERS-CoV), CRISPR-CASc mice expressing human hDPP4 and Alpacas (camelid).

MERSRAB is immunogenic in mice and protects against challenge with MERS- CoV. To analyze the immunogenicity of the MERSRAB (FIG. 12 and FIG. 13), we immunized 4 groups of BALB/c mice (5 mice per group) with 10 pg of the control virus FILORABl (Ebola virus vaccine, groupl), 10 pg of MERSRAB (groups 2 and 3), or PBS (group 4) at day 0, 7, and 21 post-inoculations. We followed the immune response against RABV G and MERS-CoV S by antigen-specific ELISAs. The antigen-specific IgG responses increased over time and after each immunization; they reached high antibody levels against both RABV G and MERS-CoV S after the third inoculations. MERS-CoV- S specific immune responses were only detected in groups 2 and 3, but RABV G specific IgG was detected in groups 1-3. None of the animals of group 4, which were mock immunized, demonstrated immune responses against RABV G or MERS-CoV S protein, confirming the specificity of the ELISAs assays. Whereas the RABV G-specific ELISA titers are known to predict protection against RABV challenge (22-24), the protective abilities of the MERS-CoV S-directed antibodies are unknown. Therefore VNA was performed against MERS-CoV of sera on day 35 of the immunized mice of all four groups. Low levels of MERS-CoV neutralizing antibodies were detected in the sera of mice from group 1 (FILORAB1) or mock (PBS) immunized mice (group 4), but the sera of mice immunized with MERSRAB (group 2 and 3) neutralized MERS-CoV at serum dilutions between 1:1280 and 1:5120. This demonstrates a high level of anti-MERS-CoV neutralizing antibody produced in the BNSP333-S1 vaccinated mice.

Efficacy testing of the RABV-MERS vaccine was performed using the adenovirus-hDPP4 transduced mouse model (25). All four groups of mice were transduced, and after five days, mice in groups 1, 2, and 4 were challenged intranasally (IN) with MERS-CoV at 1 x 10⁵ pfu/mouse (strain Jordan-n3/2012). Four days after the challenge, the mice were euthanized, and their lungs were dissected, homogenized, and assayed for viral load by qRT-PCR and a viral plaque assay. For BNSP333-S1 immunized mice, both genomic and mRNA were reduced to background levels similar to those found in mice not transduced by the Ad5 -expressing hDPP4. Moreover, the immunization with BNSP333-S1 reduced the viral load in the lungs to a level below detection of the assay. In the next step the RABV based vaccine MERSRAB was tested in the CRISPR-CAS generated transgenic mouse model (mice expressing human hDPP4). Transgenic mice in groups of 10 mice were immunized with 10 pg of the control virus FILORAB (Empty vector, group Rabies control vaccine), 10 pg of MERSRAB (MERS/Rabies dual vaccine), at day 0, 7, and 28 or only at day 0 and 28 (FIG. 13). The immune response against RABV G and MERS-CoV S was followed by antigen-specific ELISAs. The antigen- specific IgG responses increased over time and after each immunization; they reached high antibody levels against both RABV G and MERS-CoV S after the second or third immunization. MERS-CoV-S specific immune responses were only detected in groups 1 and 2 (MERS-Rabies), but RAB V G specific IgG was detected in all three groups.

Whereas the RABV G-specific ELISA titers are known to predict protection against RABV challenge (22-24), the protective abilities of the MERS-CoV S-directed antibodies are not well characterized. The transgenic mice were therefore challenged with pathogenic MERS-CoV at day 56. As shown in FIG. 14A all immunized mice survived the infection whereas 40% of the mock immunized animals succumbed to the infection. As shown all mice, which received one or two inoculation with the MERSRAB were protected from weight-loss completely. Moreover, immunization did reduce viral loads to undetectable levels (FIGS. 14A-14C) whereas the MERS-CoV replicated to very high levels in empty vector immunized animals (FIG. 14C). This can also be seen in FIG. 15. Two or three inoculations with MERSRAB protect animals from viral replication in the lung and MERS-CoV antigen in lungs of immunized mice is detected at day three after challenge, no antigen is detected at day six. In contrast, the lung tissue of animal immunized with the vector only, large amount of tissue damage and viral antigen can be detected at both time points consistent with the viral load shown in FIGS. 14A-14C.

Lastly, to determine the potential of preventing transmission from host species to humans, the next study tested if the MERSRAB vaccine was efficacious in Camelids. In brief, a group of five Alpacas were immunized with 107 foci forming units (ffu) of live MERSRAB i.m., or intranasally or immunized i.m. with 100 pg or 300 pg of the inactivated MERSRAB vaccine. After 56 days the animals were challenged with MERS- CoV intranasally and nasal swabs were taken over time to analyse viral shedding. No disease was detected after immunization with either the live or the killed MERSRAB vaccine. As shown in FIG. 15, two inoculations with 100 or 300 pg resulted in almost complete suppression of viral shedding from the infected animals.

Inactivated RABV has a 30-year long history as an efficient and safe vaccine. Taken together, the results presented above clearly indicate that a vaccine based on deactivated RABV particles is a strong candidate against 2019-nCoV infection.

Furthermore, the use of an adjuvant might allow clinical benefit after just one vaccination. Appropriate adjuvant selection is likely be critical to design of a safe and effective nCoV vaccine. Notably, vaccine-enhanced eosinophilic lung disease was seen to be exacerbated when SARS vaccines were formulated with aluminium salt adjuvants whereas it was completely prevented when the same SARS vaccines were formulated with Advax-SM adjuvant, which is a formulation of polysaccharide particles combined with a potent TLR9 agonist. The addition of Advax to a broad range of vaccines results in significant benefits including enhanced protection associated with higher antibody titers, increased B cell receptor affinity maturation, IgG subtype diversification, enhanced memory CD4 and CD8 T cell responses and antigen dose sparing. Advax adjuvant have been shown to provide protective immunity with a single dose in neonatal pups. A particular advantage of Advax adjuvants is that they have already been shown to be safe and well tolerated in human clinical trials in combination with many different antigens thereby facilitating rapid translation of successful vaccines from preclinical studies to human trials.

Adjuvants increase the immunity of vaccines and can also change the antibody isotype. It was previously shown for a rabies virus platform that the addition of MPLA in squalene (PHAD®) increased both the total humoral responses as well as the Thl/TH2 bias. For most viral vaccines, it has been shown that a THl-bias is beneficial. It has been demonstrated a TH1 bias is necessary for robust protection against EBOV by the FILORABl vaccine. For the 2019-nCoV vaccine, the MPLA 3D(6-acyl)PHAD® in 2% Squalene can be used as well as an adjuvant with the potential to increase immunity and induce TH1 responses (e.g., CpG-Oligodeoxynucleotide).

Example 3 Preclinical studies

The following describes preclinical studies to test the 2019-nCoV vaccine:

1) Most critical is the ability to test efficacy in animal models (small animal and NHP), which will be performed in parallel to the proposed Phase 1 clinical trial to evaluate safety and immunogenicity and potential adverse effects such as enhancement of infection after vaccination. Because 2019-nCoV and the SARS-CoV seem to utilize the same receptor the human ACE2 transgenic mice may be a suitable model for 2019-nCoV, however evaluation of this model has not been characterized and experiments to confirm the model are in the planning stages. NHP animal modelling is expected to start in mid- March 2020. Cynomolgus monkeys, African Green monkeys, common marmosets, and rhesus monkeys will be evaluated for disease development following intratracheal, small- particle aerosol, or large-particle aerosol. The IRF-Frederick has experience with MERS, ebola virus, nipah virus and cowpox aerosol models. The unique positron emission tomography with computed tomography (PET/CT will be incorporated into the animal model to measure disease progression since the nonhuman primate model is expected to be sublethal. CT has been used previously to demonstrate vaccine efficacy and to complement small molecule countermeasure efficacy tests (www.ncbi.nlm.nih.gov/pubmed/26218507 and www.ncbi.nlm.nih.gov/pmc/articles/PMC5640857/).

CT has also been used to evaluated a MERS monoclonal antibody in the rhesus monkey model of MERS and to evaluate disease progression in the common marmoset model of MERS (www.ncbi.nlm.nih.gov/pubmed/26828465 and www.ncbi.nlm.nih.gov/pubmed/26342468)

2) Characterization of the 2019-nCoV vaccine by biochemical and virological assay at TJU

3) Recovery of the vaccine at BBIL under GLP

4) Establish VNA against the 2019-nCoV strain. Establish pseudotype VNA assay for BSL2

5) ELISA for 2019-nCoV S - similar to the previously developed ELISA for MERS-CoV S.

6) Formulation of the vaccine and adjuvant.

Example 4 Clinical studies

The following describes clinical studies to test the 2019-nCoV vaccine:

Based on the information from preclinical studies, efficacy in animal models will be performed in parallel to the proposed Phase 1 clinical trial to evaluate safety and immunogenicity in human subjects. Of note, our previous discussion (pre-IND) with the FDA for a similar killed rabies-virus based vaccine against EBOV was agreed not to require a toxicity study based on the safety history of deactivated rabies vaccines applied to more than 100 million people. The phase 1 study, if successful, would be followed by a Phase 2 clinical trial to increase the upper end of the age spectrum (since older persons have most severe 2019 nCoV disease) and to expand the cohort size to obtain statistically valid data related to the immune response.

Target populations: Healthy U.S. adults 18 through 55 years of age, inclusive.

Clinical Trial Design: Phase 1 Clinical Trial.

The Phase 1 trial is a randomized, observer-blinded, dose-escalation study to evaluate the safety, reactogenicity, and immunogenicity of the inactivated rabies virus (RABV) based 2019-nCoV vaccine candidates (RABV-nCoV). The clinical trial will be performed at a single site at the University of Maryland, Baltimore, in healthy adults 18 through 55 years of age. Enrolment will proceed in a staged fashion. We will being with 8 subjects in cohort 1. If no pausing rules are met by day 8 following the first dose of vaccine, then cohort 2 can begin immediately after full enrolment of Cohort 1, with no pausing. Cohorts 3 and 4 will proceed simultaneously after review of day 8 data in cohort 2 (assuming no halting rules are met. Importantly, we will include a single dose arm with adjuvant that will commence simultaneously with the 100 ug group (so groups 3 and 4 will be enrolled together after safety data available from all of group 2 through day 8). The study consists of four cohorts totaling 64 subjects (2 rabies vaccine controls and 14 investigational vaccines in each cohort). All study injections will be administered by the intramuscular (IM) route. Treatment assignments are outlined in Table 1.

Table 1: Treatment Assignment for the Phase I Ranging Safety Study of the nCoVRAB Vaccine

Primary Objective: To assess the safety and tolerability of a 2-dose schedule of the unadjuvanted nCoVRAB and a 1-dose schedule of the adjuvanted vaccine candidates delivered IM at 0 and 28 days.

Secondary Objective: To evaluate the immunogenicity of the nCoVRAB vaccine candidates delivered IM at 0 and 28 days (or day 0 for adjuvanted) at escalating dose levels at Days 0, 28, 56, 120 (with primary measure at day 56 for unadjuvanted and day 28 for adjuvanted). Primary Endpoints: The number and percentage of study participants who experience any study injection -associated adverse events, solicited systemic events, or serious adverse events at the following time points:

• Solicited events for 7 days after each study injection.

• Unsolicited events through 28 days after the last study injection (Day 56).

• Serious adverse events (SAEs) for 56 days and at Days 56 and 120 and 365 per a scripted interview.

• Number of participants with early discontinuation of study inj ections and reason for discontinuation.

Secondary Endpoints: Immunogenicity as measured by ELISA to 2019-nCoV and rabies GP.

• nCoV SI- and nCoV SI and RABV G specific serum IgG ELISA titers per time point through Day 120: geometric mean antibody titers (GMT) and percentage of subjects seroconverting (4-fold rise over baseline).

• nCoV and rabies neutralizing antibody titers through Day 120: GMT and percentage of subjects seroconverting (4-fold rise over baseline); for rabies, percentage of subjects with titers > 0.5 IU/ml (correlate of protection).

Exploratory (future studies)

• Antigen-specific serum IgM, IgA and IgG subclasses (selected time-points).

• T cell responses (Thl, Th2 and Thl7 cytokines and chemokines post vaccination).

• B cell responses (magnitude of antigen-specific plasmablasts and memory B cells post vaccination).

• IgG avidity.

Phase 2 Clinical Trial

This clinical trial is proposed as a Phase 2, randomized, observer-blinded, single antigen level study to evaluate the safety and immunogenicity of a two Dose Rabies- Vectored nCoVRAB Vaccine (or a one dose adjuvanted regimen). Given the demographics of the current NCoV outbreak, we will expand the upper age to 70 years . Volunteers will be assessed before the injection and days 1, 3, 7, 14, and 28 after the vaccine for safety, reactogenicity, and immunogenicity. The clinical trial will be performed in healthy adults meeting all inclusion criteria and no exclusion criteria at 2 sites in the US - Baltimore, MD and one additional site total of 200 adults will be consecutively enrolled into groups, stratified by age. All study injections will be administered by the intramuscular (IM) route. Treatment assignments are outlined in Table 2 below.

Table 2: Treatment Assignment for the First Dose Ranging Safety Study of the nCoVRAB Vaccine*

* The overall antigen dose, the relative concentration of the antigen component used for this study will depend upon the outcome of the Phase 1 clinical trial.

Primary Objective: To assess the safety and tolerability of a leading nCoVRAB vaccine candidates delivered IM at 0 and 28 days.

Secondary Objective: To evaluate the immunogenicity of the nCoVRAB vaccine candidates delivered IM at 0 and 28 days at Days 7, 14, 28, 35, 42, 56, 90, 120, 180, and 365.

Primary Endpoints: The number and percentage of study participants who experience any study injection-associated adverse events or serious adverse events at the following time point:

• Solicited events for 7 days after each study injection.

• Unsolicited events through 28 days after the last study injection (Day 56).

• Serious adverse events (SAEs) for 56 days and at Days 56 and 120 and 365 per a scripted interview.

• Number of participants with early discontinuation of study inj ections and reason for discontinuation.

Secondary Endpoints/Exploratory endpoints see above (Phase 1 Clinical Trial.)

Example 5 Manufacturing

In the setting of the public health emergency of 2019 Novel Coronavirus (2019- nCoV or SARS-CoV-2), considerations for the development of a 2019-nCoV vaccine must balance manufacturing speed and technical feasibility with clinical safety and immunogenicity considerations. Ultimately, the manufacturing must be scalable, and the delivery simple in order to reach the maximum number of people in the shortest period of time. A collaborator, Bharat Biotech Ltd (BBIL) is a large vaccine manufacturer with the ability to scale production of such a vaccine to millions of doses rapidly. Relying on an existing technology to maximize feasibility and speed of development is the best approach to achieving this goal.

BBIL experience in positioning licensed vaccines for International supplies is summarized in the table below.

Experience in manufacture and scale-up/ Infrastructures and facilities

BBIL has several facilities for the manufacturing of Viral, Bacterial and recombinant Drug Substance. BBIL is the largest viral vaccine manufacturer in India. For the manufacturing of viral vaccines, it possesses expertise in the utilization of Vero, MDCK cell lines and platforms like Cell factories, Micro carriers and fermenters. There are 5 viral bulk manufacturing facilities including a pilot plant, these facilities have capabilities ranging from 50 L to 1000 L fermentation and purification by TFF, Gel permeation and Affinity chromatography. These automated facilities can produce up to 500 million doses of vaccines.

BBIL also has capabilities of manufacturing recombinant and bacterial drug substances and these are manufactured in 6 facilities including one pilot plant, BBIL expertise ranges from usage of recombinant E. coli, Yeast, Toxins producing bacteria such as, Diphtheria, tetanus and Whole cell bacteria viz pertussis and Cholera. These organisms are processed from 50 L to 1500 L fermenters and subsequent purifications are carried out using either Ion Exchange, Gel permeation chromatography’s.

For Drug Product, all bulk product is either filled in vials, PFS or BFS ranging from 0.5 ML to 25 ml capacities in filling machine having capacity from 50 - 300 vials per min.Keeping in view, of the various products manufactured and also the products to be manufactured in future, BBIL has a Developmental QC Lab, which in involved in the development and validation of different assays and a Strong QC department for routine batch testing and release of all vaccines and biotherapeutics.

Manufacturing capacity: Approximately, 500 million doses of vaccines and 4 million units of Bio-therapeutics are manufactured per year. About 20-30% of the vaccines are supplied to GAVI countries. With a strong QC department, BBIL manufacture, test and release following vaccines and biotherapeutics. Apart from the facilities available at BBIL, in case of Emergency situation, higher manufacturing capacities of 5,000 L, at BSL3/Ag+ facility is available at BIO VET, Bengaluru.

Example 6

CORA VAX (rDNA-BBV151)

To evaluate the reactogenicity and safety of BBV151 (inactivated rabies vector platform Corona Vims) vaccine administered via the intramuscular route, a dose escalation study of an intramuscular inactivated rabies vector platform Corona Vims Vaccine (rDNA-BBV151) in healthy volunteers will be performed.

CORAVAX (rDNA-BBV151) is an adjuvanted rabies vectored Corona vims vaccine, that express the S 1 domain of the SARSCoV-2 spike (S) protein fused to part of the N terminal domain of the RABV glycoprotein (G) and is incorporated in RABV particles. CORAVAX (rDNA- BBV151) vaccine has two presentations.

PRESENTATION 1 (BBV151-A) - Ingredients I and II will be provided as two separate vials (each 0.5 mL) and these two vials (A and B) will be mixed at the time of administration. The final reconstituted 1.0 mL volume is equivalent to 2 doses. BBV151-A presentation has two vaccine formulations with a variation in the dosage strength of active ingredient (Figure XA): BBV151-A1: BBV151-A1 formulation has 15 meg of the active ingredient.

BBV151-A2: BBV151-A2 formulation has 30 meg of the active ingredient. PRESENTATION 2 (BBV151-B): Ingredients I and II will be mixed together, before itself and will be provided as a single vial (0.5mL dose volume). BBV151-B presentation has only one formulation (Figure XB):

BBV151-B: BBV151-B formulation has 30 meg of the active ingredient.

The study is designed to evaluate the safety, reactogenicity, and immunogenicity of four groups of healthy volunteers who receive either vaccine or placebo.

Group 1 (BBV151-A1): In this group, 15 participants will be recruited and administered with BBV151-Al vaccine formulation on day 0 and day 28 via intramuscular route.

Group 2 (BBV151-A2): In this group, 15 participants will be recruited and administered with BBV151-A2 vaccine formulation on day 0 and day 28 via intramuscular route.

Group 3 (BBV151-B): In this group, 15 participants will be recruited and administered with BBV151-B vaccine formulation on day 0 via intramuscular route.

Data will be un-blinded to the third-party bio-statistician and an interim analysis will be performed at day 42 for Immunogenicity and Safety. nAb titer of the COVID-19 virus will be assessed by the MNT/PRNT assay and evaluate the immunogenicity in terms of GMT of vaccine comparison with the placebo group. Serum samples will be assessed for nAb. Binding antibody titer against spike protein of SARS-CoV-2 virus will be assessed for serum samples by using ELISA. Cell Mediated Immunity will be assessed from the subset of the study population.

The GMT will be calculated for neutralization titers in each vaccine group (one dose and two doses) separately. A two-sided 95% confidence interval (Cl) for the GMT will be calculated from a 95% Cl for the mean of logio-transformed titer, using a normal approximation for the distribution of logio (titer). The ratio of GMTs in the two vaccine groups (GMT with two doses / GMT with one dose) and the corresponding 95% Cl will also be presented. The two-sided 95% Cl for the GMT ratio will be calculated from a 95% Cl for the difference in means of logio (titer). The two vaccine groups will be compared using a two-sided two-sample t-test on the means of logio- transformed titers, at the 5% significance level.

To evaluate the humoral immune responses of BBV151, GMT and four-fold seroconversion rate (SCR) of neutralizing antibodies (NAb’s) by MNT/PRNT assays across the three groups, from baseline to days 28±2, 42±2, 90±7 and 180±7, will be performed.

To compare the humoral responses between single dose group and double dose group, GMT and four-fold seroconversion rate (SCR) of neutralizing antibodies (NAb’s) by MNT/PRNT assays across the three groups, from baseline to days 28+2, 42+2, 90+7 and 180+7.

To evaluate the immune responses against spike protein of SARS-CoV-2 virus and Rabies vector, GMT and four-fold seroconversion rate of binding antibodies (bAb’s) IgA and IgG against spike protein across the three groups, from baseline to days 28+2, 42+2, 90+7 and 180+7, will be determined. Immune response (binding/ or neutralization) to the vector will be assessed by ELISA from baseline to days 28+2, 42+2, 90+7 and 180+7.

To evaluate the safety of the vaccine in terms of assessing adverse event of special interest (AESI), the occurrence of AESI will be monitored and documented throughout the study duration.

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Other Embodiments

The recitation of a listing of elements in any definition of a variable herein includes definitions of that variable as any single element or combination (or subcombination) of listed elements. The recitation of an embodiment herein includes that embodiment as any single embodiment or in combination with any other embodiments or portions thereof.

The disclosures of each and every patent, patent application, and publication cited herein are hereby incorporated herein by reference in their entirety. While this invention has been disclosed with reference to specific embodiments, it is apparent that other embodiments and variations of this invention may be devised by others skilled in the art without departing from the true spirit and scope of the invention. The appended claims are intended to be construed to include all such embodiments and equivalent variations.

Claims

What is claimed is:

1. An isolated nucleic acid encoding a recombinant virus comprising a SARS-CoV-2 spike protein (S) or a portion thereof.

2. An isolated nucleic acid encoding a virus selected from a rabies virus, a vesicular stomatitis virus (VSV), and a measles virus, wherein the virus comprises a SARS-CoV-2 spike protein (S) or a portion thereof.

3. The isolated nucleic acid of claim 1, wherein the virus is a rabies virus, a vesicular stomatitis virus (VSV), or a measles virus.

4. The isolated nucleic acid of claim 1, wherein the virus is a rhabdovirus.

5. The isolated nucleic acid of any one of claims 1-4, wherein the portion of the SARS-CoV-2 spike protein (S) is a receptor binding site of the SARS-CoV-2 spike protein (S).

6. The isolated nucleic acid of any one of claims 1-5, wherein the portion of the SARS-CoV-2 spike protein (S) is the SI domain.

7. The isolated nucleic acid of any one of claims 1-6, wherein the isolated nucleic acid comprises a sequence encoding at least a portion of the genome of the virus.

8. The isolated nucleic acid of any one of claims 1-7, wherein the nucleic acid comprises (a) a sequence encoding at least a portion of the genome of a measles virus and (b) a sequence encoding a SARS-CoV-2 spike protein (S) or a portion thereof.

9. The isolated nucleic acid of claim 8, wherein the sequence encoding the SARS- CoV-2 spike protein (S) or portion thereof is inserted into positions 2, 3, or 6 of the genome of the measles virus.

10. The isolated nucleic acid of any one of claims 1-7, wherein the nucleic acid comprises (a) a sequence encoding at least a portion of the genome of a rabies virus and (b) a sequence encoding a protein comprising a SARS-CoV-2 spike protein (S) or a portion thereof.

11. The isolated nucleic acid of claim 10, wherein the at least a portion of the genome of the rabies virus comprises an N gene and a P gene, and the sequence encoding the protein comprising the SARS-CoV-2 spike protein (S) or portion thereof is inserted into a position between the N gene and P gene.

12. The isolated nucleic acid of any one of claims 1-7, wherein the nucleic acid comprises (a) a sequence encoding at least a portion of the genome of a vesicular stomatitis virus (VSV), and (b) a sequence encoding a protein comprising a SARS-CoV-2 spike protein (S) or a portion thereof.

13. The isolated nucleic acid of any one of claims 10-12, wherein the protein comprising a SARS-CoV-2 spike protein (S) or a portion thereof is a fusion protein comprising a glycoprotein (G) or a portion thereof and a SARS-CoV-2 spike protein (S) or a portion thereof.

14. The isolated nucleic acid of claim 13, wherein the fusion protein comprises a glycoprotein (G) or portion thereof fused to the SI domain of a SARS-CoV-2 spike protein (S).

15. The isolated nucleic acid of any one of claims 1-14, wherein the nucleic acid comprises a sequence set forth in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, or SEQ ID NO: 5.

16. An isolated nucleic acid encoding a recombinant fusion protein comprising (a) a glycoprotein (G) of a virus or a portion thereof, and (b) a SARS-CoV-2 spike protein (S) or a portion thereof.

17. The isolated nucleic acid of claim 16, wherein the virus is a rabies virus or a vesicular stomatitis virus (VSV).

18. The isolated nucleic acid of claim 16 or 17, wherein the portion of the SARS- CoV-2 spike protein (S) is a receptor binding site of the SARS-CoV-2 spike protein (S).

19. The isolated nucleic acid of any one of claims 16-18, wherein the portion of the SARS-CoV-2 spike protein (S) is the SI domain.

20. The isolated nucleic acid of any one of claims 16-19, wherein the fusion protein comprises a rabies virus glycoprotein (G) or portion thereof fused to the SI domain of the SARS-CoV-2 spike protein (S).

21. The isolated nucleic acid of any one of claims 16-19, wherein the fusion protein comprises a vesicular stomatitis virus (VSV) glycoprotein (G) or portion thereof fused to the SI domain of the SARS-CoV-2 spike protein (S).

22. A recombinant virus comprising a SARS-CoV-2 spike protein (S) or a portion thereof.

23. A recombinant virus selected from a rabies virus, a vesicular stomatitis virus (VSV), and a measles virus, wherein the virus comprises a SARS-CoV-2 spike protein (S) or a portion thereof.

24. The recombinant virus of claim 22 or 23, wherein the virus is a rabies virus, a vesicular stomatitis virus (VSV), or a measles virus.

25. The recombinant virus of claim 22, wherein the virus is a rhabdovirus.

26. The recombinant virus of any one of claims 22-25, wherein the portion of the SARS-CoV-2 spike protein (S) is a receptor binding site of the SARS-CoV-2 spike protein (S).

27. The recombinant virus of any one of claims 22-26, wherein the portion of the SARS-CoV-2 spike protein (S) is the SI domain.

28. The recombinant virus of any one of claims 22-27, wherein the virus comprises a fusion protein comprising a glycoprotein (G) or portion thereof and a SARS-CoV-2 spike protein (S) or a portion thereof.

29. The recombinant virus of claim 28, wherein the fusion protein comprises a glycoprotein (G) or portion thereof fused to the SI domain of a SARS-CoV-2 spike protein (S).

30. The recombinant virus of any one of claims 22-29, wherein the virus is encoded by a nucleic acid of any one of claims 1-15.

31. A recombinant fusion protein comprising (a) a glycoprotein (G) of a virus or a portion thereof, and (b) a SARS-CoV-2 spike protein (S) or a portion thereof.

32. The recombinant fusion protein of claim 31, wherein the virus is a rabies virus or a vesicular stomatitis virus (VSV).

33. The recombinant fusion protein of claim 31 or 32, wherein the portion of the SARS-CoV-2 spike protein (S) is a receptor binding site of the SARS-CoV-2 spike protein (S).

34. The recombinant fusion protein of any one of claims 31-33, wherein the portion of the SARS-CoV-2 spike protein (S) is the SI domain.

35. The recombinant fusion protein of any one of claims 31-34, wherein the fusion protein comprises a rabies virus glycoprotein (G) or portion thereof fused to the SI domain of the SARS-CoV-2 spike protein (S).

36. The recombinant fusion protein of any one of claims 31-34, wherein the fusion protein comprises a vesicular stomatitis virus (VSV) glycoprotein (G) or portion thereof fused to the SI domain of the SARS-CoV-2 spike protein (S).

37. The recombinant fusion protein of any one of claims 31-36, wherein the fusion protein is encoded by the nucleic acid of any one of claims 16-21.

38. A vector comprising the nucleic acid of any one of claims 1-21.

39. A vaccine comprising the recombinant virus of any one of claims 22-30 or the recombinant fusion protein of any one of claims 31-37, and a pharmaceutically acceptable carrier.

40. The vaccine of claim 39, further comprising an adjuvant.

41. The vaccine of claim 39 or 40, wherein the adjuvant is MPLA 3D(6-acyl) (PHAD®) in 2% squalene.

42. The vaccine of any one of claims 39-41, wherein the virus is deactivated.

43. A method of generating an immune response against a SARS-CoV-2 virus in a subject in need thereof, the method comprising administering to the subject an effective amount of the recombinant virus of any one of claims 22-30, the recombinant fusion protein of any one of claims 31-37, or the vaccine of any one of claims 39-42.

44. A method of vaccinating a subject against a SARS-CoV-2 virus, the method comprising administering to the subject an effective amount of the recombinant virus of any one of claims 22-30, the recombinant fusion protein of any one of claims 31-37, or the vaccine of any one of claims 39-42.

45. A method of providing immunity against a SARS-CoV-2 virus in a subject, the method comprising administering to the subject an effective amount of the recombinant virus of any one of claims 22-30, the recombinant fusion protein of any one of claims 31- 37, or the vaccine of any one of claims 39-42.

46. A method of treating and/or preventing a disease or disorder associated with a SARS-CoV-2 virus in a subject in need thereof, the method comprising administering to the subject an effective amount of the recombinant virus of any one of claims 22-30, the recombinant fusion protein of any one of claims 31-37, or the vaccine of any one of claims 39-42.

47. The method of any one of claims 42-46, wherein the subject is a human.

48. The method of any one of claims 42-46, wherein the subject is a cat.

49. The method of any one of claims 42-46, wherein the subject is a dog.

50. The method of any one of claims 42-46, wherein the subject is a ferret.

51. The method of claim 46, wherein the disease or disorder is COVID-19.

52. An isolated nucleic acid encoding a recombinant rabies virus comprising the SI domain of a SARS-CoV2 spike protein fused to a rabies glycoprotein (G) or portion thereof.

53. The isolated nucleic acid of claim 52, wherein the nucleic acid comprises (a) a sequence encoding at least a portion of the genome of a rabies virus, the portion comprising an N gene and a P gene, and (b) a sequence encoding the SI domain fused to the glycoprotein (G), wherein the sequence encoding the S 1 domain fused to the glycoprotein (G) is inserted into a position between the N gene and the P gene.

54. The isolated nucleic acid of claim 52 or 53, wherein the glycoprotein (G) comprises a mutation substituting arginine with glutamic acid at position 333.

55. The isolated nucleic acid of any one of claims 52-54, wherein the SI domain of the SARS-CoV2 spike protein is fused to a portion of the glycoprotein (G), the portion comprising an ectodomain, a cytoplasmic domain, and a transmembrane domain.

56. The isolated nucleic acid of claim 55, wherein the portion of the glycoprotein (G) comprises 31 amino acids of the ectodomain and the full-length cytoplasmic domain.

57. The isolated nucleic acid of any one of claims 52-56, wherein the SI domain is fused to the C-terminus of the glycoprotein (G).

58. The isolated nucleic acid of any one of claims 53-57, wherein the sequence encoding the SI domain fused to the glycoprotein (G) is codon-optimized for expression in a cell.

59. A recombinant virus encoded by the nucleic acid of any one of claims 52-58.

60. The recombinant virus of claim 59, wherein the virus is deactivated.

61. A vaccine comprising the recombinant virus of claim 59 or 60, and a pharmaceutically acceptable carrier.

62. The vaccine of claim 61, further comprising an adjuvant.

63. The vaccine of claim 62, wherein the adjuvant is MPLA 3D(6-acyl) (PHAD®) in 2% squalene.

64. A method of generating an immune response against a SARS-CoV-2 virus in a subject in need thereof, the method comprising administering to the subject an effective amount of the recombinant virus of any one of claims 59-60 or the vaccine of any one of claims 61-63.

65. A method of vaccinating a subject against a SARS-CoV-2 virus, the method comprising administering to the subject an effective amount of the recombinant virus of any one of claims 59-60 or the vaccine any one of claims 61-63.

66. A method of providing immunity against a SARS-CoV-2 virus in a subject, the method comprising administering to the subject an effective amount of the recombinant virus of any one of claims 59-60 or the vaccine any one of claims 61-63.

67. A method of treating and/or preventing a disease or disorder associated with SARS-CoV-2 virus in a subject in need thereof, the method comprising administering to the subject an effective amount of the recombinant virus of any one of claims 59-60 or the vaccine any one of claims 61-63.

68. The method of any one of claims 64-67, wherein the subject is a human.

69. The method of any one of claims 64-67, wherein the subject is a cat.

70. The method of any one of claims 64-67, wherein the subject is a dog.

71. The method of any one of claims 64-67, wherein the subject is a ferret.

72. The method of claim 67, wherein the disease or disorder is COVID-19.

73. A method of generating an immune response against a rabies virus and a SARS- CoV-2 virus in a subject in need thereof, the method comprising administering to the subject an effective amount of a vaccine comprising a recombinant rabies virus comprising a SARS-CoV-2 spike protein (S) or portion thereof.

74. A method of vaccinating a subject against a rabies virus and a SARS-CoV-2 virus, the method comprising administering to the subject an effective amount of a vaccine comprising a recombinant rabies virus comprising a SARS-CoV-2 spike protein (S) or portion thereof.

75. A method of providing immunity against a rabies virus and a SARS-CoV-2 virus in a subject, the method comprising administering to the subject an effective amount of a vaccine comprising a recombinant rabies virus comprising a SARS-CoV-2 spike protein (S) or portion thereof.

76. A method of treating and/or preventing a disease or disorder associated with a rabies virus and a disease or disorder associated with SARS-CoV-2 virus in a subject in need thereof, the method comprising administering to the subject an effective amount of a vaccine comprising a recombinant rabies virus comprising a SARS-CoV-2 spike protein (S) or portion thereof.

77. The method of any one of claims 73-76, wherein the recombinant rabies virus comprises an SI domain of a SARS-CoV-2 spike protein fused to a rabies glycoprotein (G) or portion thereof.

78. The method of any one of claims 73-77, wherein the recombinant rabies virus is deactivated.

79. The method of any one of claims 73-78, wherein the vaccine comprises an adjuvant.

80. The method of any one of claims 73-79, wherein the subject is non-human.

81. The method of any one of claims 73-80, wherein the subject is a mammal.

82. The method of any one of claims 73-81, wherein the subject is a domestic pet or livestock.

83. The method of any one of claims 73-82, wherein the subject is a cat.

84. The method of any one of claims 73-82, wherein the subject is a dog.

85. The method of any one of claims 73-82, wherein the subject is a ferret.