WO2020218439A1 - 流路デバイス、カートリッジ及び測定システム - Google Patents

流路デバイス、カートリッジ及び測定システム Download PDF

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Publication number
WO2020218439A1
WO2020218439A1 PCT/JP2020/017540 JP2020017540W WO2020218439A1 WO 2020218439 A1 WO2020218439 A1 WO 2020218439A1 JP 2020017540 W JP2020017540 W JP 2020017540W WO 2020218439 A1 WO2020218439 A1 WO 2020218439A1
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WO
WIPO (PCT)
Prior art keywords
flow path
storage chamber
chamber
sample
syringe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2020/017540
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English (en)
French (fr)
Japanese (ja)
Inventor
池田　豊
和典 元津
崇宏 砂田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyocera Corp
Original Assignee
Kyocera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyocera Corp filed Critical Kyocera Corp
Priority to EP20795032.0A priority Critical patent/EP3961226A4/en
Priority to CN202080030647.2A priority patent/CN113728235A/zh
Priority to US17/605,989 priority patent/US20220212474A1/en
Priority to JP2021516213A priority patent/JPWO2020218439A1/ja
Publication of WO2020218439A1 publication Critical patent/WO2020218439A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

Definitions

  • the present disclosure relates to flow path devices, cartridges and measurement systems.
  • Patent Document 1 an inspection instrument provided with a sample supply port, a measurement room, and a flow path communicating these is known.
  • the flow path device is A storage room that has a ceiling surface and a bottom surface and can store samples, An inflow port communicating the outside of the storage chamber and the storage chamber so that the sample can flow into the storage chamber from the outside of the storage chamber.
  • a flow path that is connected to the upper part of the storage chamber at a position away from the inlet and allows the sample to flow out of the storage chamber.
  • a convex portion that protrudes from the ceiling surface of the storage chamber toward the bottom surface of the storage chamber and is located between the inflow port and the flow path. With The convex portion limits the space in which the space on the inflow port side of the storage chamber and the space on the flow path side of the storage chamber communicate with each other to a predetermined height or less from the bottom surface of the storage chamber.
  • the cartridge according to the embodiment of the present disclosure is With the above-mentioned flow path device
  • the sensor unit connected to the flow path of the flow path device and To be equipped.
  • the measurement system according to the embodiment of the present disclosure is with the above cartridge Equipped with an air extruder,
  • the air extruder is A tubular syringe containing a tip that can be inserted into the inlet, It has a plunger that can move in the syringe and can extrude air in the syringe to the tip portion.
  • FIG. 5 is a cross-sectional view of another example of the flow path device shown in FIG.
  • the present disclosure relates to providing a flow path device, a cartridge, and a measurement system that can easily control the timing of supplying a sample to a sensor unit.
  • the timing of supplying the sample to the sensor unit can be easily controlled.
  • the direction in which the flow path device 2 as shown in FIG. 1 is inserted into the measuring device 3 is the positive direction of the X-axis.
  • the direction in which gravity acts is the positive direction of the Z axis.
  • the positive direction of the Y-axis is determined to constitute Cartesian coordinates of the right-handed system.
  • downward means the direction in which gravity acts, that is, the positive direction of the Z axis.
  • upper means a direction opposite to the direction in which gravity acts, that is, a negative direction of the Z axis.
  • the measuring system 1 includes a measuring device 3 and a cartridge 4.
  • the cartridge 4 includes a substrate 5.
  • the cartridge 4 includes a flow path device 2 and a sensor unit 6 on a substrate 5.
  • the sensor unit 6 may be configured as a separate body from the substrate 5.
  • the sensor unit 6 may be arranged in the measuring device 3.
  • the flow path device 2 includes a storage chamber 41 described later.
  • Specimen 7 is stored in the storage chamber 41.
  • Examples of the sample 7 include human blood, human cerebrospinal fluid, human urine, and the like.
  • a pretreatment may be appropriately performed on the sample 7.
  • the measuring device 3 has a housing 3A and an insertion port 3B.
  • the housing 3A may be made of a metal material, a synthetic resin material, or the like.
  • the cartridge 4 is inserted into the measuring device 3 from the insertion port 3B.
  • the cartridge 4 is arranged inside the measuring device 3 by being inserted from the insertion port 3B of the measuring device 3.
  • the sensor unit 6 outputs an electric signal according to the components contained in the sample 7.
  • the sensor unit 6 may be composed of a sensor or the like using a surface acoustic wave (SAW).
  • SAW surface acoustic wave
  • the measuring device 3 acquires the electric signal output by the sensor unit 6.
  • the measuring device 3 measures the components and the like contained in the sample 7 based on the acquired electric signal and the like.
  • the sensor unit 6 is arranged in the area 10.
  • the region 10 is located on the substrate 5 on the positive side of the X-axis with respect to the flow path device 2.
  • the flow path device 2 includes a storage chamber 41, a flow path 48, an inflow port 50, and a convex portion 51.
  • the flow path device 2 includes protrusions 49A and 49B (a pair of protrusions).
  • the substrate 5 includes an upper substrate 20, a small plate 30, a sheet member 36, and a lower substrate 40.
  • the upper substrate 20 is located above the lower substrate 40.
  • the upper substrate 20 may be made of a synthetic resin material or the like.
  • the upper substrate 20 forms an accommodating portion 25, an inner surface 23 and a wall surface 24 forming the accommodating portion 25, an opening 22 penetrating the outside of the substrate 5 and the accommodating portion 25, and an opening 22. It has a wall surface 21.
  • the opening 22 is specified as an area surrounded by the wall surface 21. As shown in FIG. 2, the opening 22 may be circular, for example, in top view.
  • the accommodating portion 25 is specified as an area surrounded by the inner surface 23 and the wall surface 24.
  • a small plate 30 is accommodated in the accommodating portion 25.
  • the size and shape of the accommodating portion 25 may be appropriately adjusted according to the size of the small plate 30.
  • the small plate 30 is located between the upper substrate 20 and the lower substrate 40.
  • the small plate 30 is housed in the housing portion 25 of the upper substrate 20.
  • the small plate 30 may be made of a synthetic resin material or the like.
  • the small plate 30 includes an upper surface 31, a lower surface 32, an opening 33 penetrating the upper surface 31 side and the lower surface 32 side, and a wall surface 34 forming the opening 33. including.
  • the upper surface 31 faces the inner surface 23 of the upper substrate 20.
  • An adhesive member 35 may be appropriately arranged between the upper surface 31 and the inner surface 23 of the upper substrate 20.
  • the adhesive member 35 may be any adhesive appropriately selected according to the material of the small plate 30 and the material of the upper substrate 20.
  • the lower surface 32 faces the lower substrate 40. As shown in FIG. 5, a convex portion 51 is provided on the lower surface 32.
  • the opening 33 is specified as an area surrounded by the wall surface 34. As shown in FIG. 4, the opening 33 may be circular in a top view. As shown in FIG. 3, the inner diameter of the opening 33 may be smaller than the inner diameter of the opening 22 of the upper substrate 20. The inner diameter of the opening 33 may be appropriately adjusted according to the outer diameter of the tip 84 of the syringe 81 of the air extruder 80 described later (FIG. 6).
  • the sheet member 36 is arranged so as to cover the gap formed between the wall surface 24 of the upper substrate 20 and the end portion of the small plate 30 from below.
  • the sheet member 36 may be made of, for example, a synthetic resin or the like.
  • the lower substrate 40 is located below the upper substrate 20.
  • the lower substrate 40 may be made of a synthetic resin material or the like.
  • the lower substrate 40 may have a recess 40A that opens upward.
  • the recess 40A includes a bottom surface 43, a bottom surface 41a, a bottom surface 46, a wall surface 44, a wall surface 41b, and a wall surface 47.
  • the storage chamber 41 as shown in FIG. 3 is specified as an area surrounded by the lower surface 32 of the small plate 30 and the surface included in the recess 40A as shown in FIG.
  • the storage chamber 41 includes a lower surface 32 of the small plate 30 as shown in FIG. 3, a bottom surface 41a, a bottom surface 43 and a bottom surface 46 included in the recess 40A as shown in FIG. 4, and a wall surface 41b included in the recess 40A. It is surrounded by the wall surface 44 and the wall surface 47 and is specified as an area.
  • the portion that specifies the storage chamber 41 is also referred to as the “ceiling surface” of the storage chamber 41.
  • the storage chamber 41 is located in the substrate 5.
  • the storage chamber 41 communicates with the outside of the substrate 5 via an inflow port 50 including the opening 22 and the opening 33.
  • the storage chamber 41 communicates with the outside of the storage chamber 41 via the inflow port 50.
  • the storage chamber 41 can store the sample 7.
  • the sample 7 dropped by the user toward the inflow port 50 is supplied to the storage chamber 41 through the inflow port 50.
  • the storage chamber 41 stores the sample 7 supplied through the inflow port 50.
  • the sample 7 may accumulate under the storage chamber 41 due to the gravity acting on the sample 7.
  • the sample 7 is stored in the storage chamber 41 until the measurement of the sample 7 by the sensor unit 6 as shown in FIG. 2 is started.
  • the sample 7 stored in the storage chamber 41 passes through the flow path 48 as shown in FIG. 2 and enters the sensor unit 6 in the region 10. Be supplied.
  • the storage chamber 41 may include a first chamber 42 and a second chamber 45.
  • the storage chamber 41 may include a space 41A between the first chamber 42 and the second chamber 45.
  • the space 41A includes a portion specified as a region surrounded by the bottom surface 41a and the wall surface 41b.
  • the first chamber 42 and the second chamber 45 communicate with each other via the space 41A.
  • the convex portion 51 is located in the space 41A. By locating the convex portion 51 in the space 41A, as will be described later, most of the sample 7 as shown in FIG. 3 can be blocked by the first chamber 42 side in the storage chamber 41.
  • the first chamber 42 is specified as an area surrounded by the lower surface 32, the lower surface 43, and the wall surface 44 of the small plate 30.
  • a part of the upper part of the first chamber 42 communicates with the inflow port 50.
  • a part of the first chamber 42 on the positive direction side of the X-axis communicates with the second chamber 45 via the space 41A.
  • the sample 7 flowing in from the inflow port 50 can be stored in the first chamber 42.
  • the positive direction side of the X-axis of the bottom surface 43 is connected to the bottom surface 41a of the space 41A.
  • a part of the bottom surface 43 on the positive direction side of the X axis may be a plane along the XY plane.
  • a part of the bottom surface 43 on the negative direction side of the X axis may be an inclined surface that inclines toward the negative direction side of the Z axis toward the negative direction side of the X axis.
  • the wall surface 44 is connected to the wall surface 41b of the space 41A.
  • the bottom surface 43 may be a substantially rectangular shape extending along the XY plane.
  • the wall surface 44 may extend from a part of the periphery of the bottom surface 43 along the negative direction of the Z axis. That is, the shape of the first chamber 42 may be a substantially rectangular parallelepiped. Since the shape of the first chamber 42 is a substantially rectangular parallelepiped, the volume of the first chamber 42 can be increased. By increasing the volume of the first chamber 42, even if the sample 7 has a relatively large amount such as human urine, the first chamber 42 can store the sample 7. Therefore, even if the sample 7 has a relatively large amount such as human urine, the probability that the sample 7 overflows from the first chamber 42 and flows out to the flow path 48 through the second chamber 45 is reduced. Can be done. With such a configuration, the sample 7 stored in the storage chamber 41 passes through the flow path 48 and is as shown in FIG. 2 before the measurement of the sample 7 by the sensor unit 6 as shown in FIG. 2 is started. The probability of reaching the sensor unit 6 can be reduced.
  • the second chamber 45 is specified as an area surrounded by the lower surface 32, the lower surface 46, and the wall surface 47 of the small plate 30.
  • the upper part of the second chamber 45 on the positive direction side of the X-axis communicates with the flow path 48.
  • the negative side of the bottom surface 46 on the X axis is connected to the bottom surface 41a of the space 41A.
  • the wall surface 47 is connected to the wall surface 41b of the space 41A.
  • the length (width) of the bottom surface 46 in the direction along the Y axis may gradually decrease toward the flow path 48.
  • the wall surface 47 may extend from a part of the periphery of the bottom surface 46 along the negative direction of the Z axis. That is, the width of the second chamber 45 may be gradually narrowed from the position where the convex portion 51 is located toward the flow path 48.
  • the bottom surface 46 may be an inclined surface inclined from the bottom surface 41a of the space 41A toward the flow path 48.
  • the volume of the storage chamber 41 can be set based on the amount of air that can be supplied by the air extruder 80 described later (FIG. 6). That is, the sum of the volume of the first chamber 42 and the volume of the second chamber 45 can be set based on the amount of air that can be supplied by the air extruder 80 described later (FIG. 6).
  • the volume of the second chamber 45 can be reduced by making the bottom surface 46 an inclined surface, and the volume of the first chamber 42 can be increased by the amount of the reduced volume of the second chamber 45.
  • the flow path 48 is located in the substrate 5.
  • the flow path 48 is specified as a region surrounded by the groove formed in the lower substrate 40 and the lower surface of the upper substrate 20 or the sheet member 36.
  • the flow path 48 is connected to the storage chamber 41 at a position away from the inflow port 50.
  • the flow path 48 is connected to the second chamber 45 of the storage chamber 41.
  • the flow path 48 extends from the storage chamber 41 to the region 10 where the sensor unit 6 is arranged. In other words, the sensor unit 6 is connected to the flow path 48.
  • the sample 7 can flow out from the storage chamber 41 to the flow path 48.
  • air is sent to the storage chamber 41 by the air extruder 80 (FIG. 7) described later.
  • the air sent to the storage chamber 41 causes the sample 7 to flow out of the storage chamber 41 into the flow path 48, as will be described later.
  • the sample 7 flowing out to the flow path 48 reaches the sensor unit 6 as shown in FIG. 2 through the flow path 48.
  • the flow path 48 is connected to the upper part of the storage chamber 41.
  • it is connected to the upper part of the second chamber 45 of the storage chamber 41.
  • the sample 7 can accumulate under the storage chamber 41 due to the gravity acting on the sample 7.
  • the flow path 48 is connected to the upper part of the storage chamber 41 before the measurement of the sample 7 by the sensor unit 6 as shown in FIG. 2 is started.
  • the probability that the sample 7 will flow into the flow path 48 can be reduced. With such a configuration, the probability that the sample 7 will reach the sensor unit 6 through the flow path 48 before the measurement of the sample 7 by the sensor unit 6 as shown in FIG. 2 is started can be reduced.
  • the protrusions 49A and 49B are located on the side of the first chamber 42 and the second chamber 45.
  • the protrusions 49A and 49B may be formed as a part of the lower substrate 40.
  • the protrusion 49A and the protrusion 49B face each other.
  • the protruding portion 49A protrudes in the negative direction of the Y axis.
  • the protruding portion 449 protrudes in the positive direction of the Y axis.
  • the inflow port 50 includes an opening 22 of the upper substrate 20 and an opening 33 of the small plate 30. That is, the inflow port 50 includes a portion specified as a region surrounded by the wall surface 21 of the upper substrate 20 and a portion specified as a region surrounded by the wall surface 34 of the small plate 30.
  • the inflow port 50 is located on the substrate 5.
  • the inflow port 50 communicates the outside of the substrate 5 with the storage chamber 41 so that the sample 7 can flow into the storage chamber 41 from the outside of the substrate 5.
  • the inflow port 50 communicates the outside of the storage chamber 41 with the storage chamber 41 so that the sample 7 can flow into the storage chamber 41 from the outside of the storage chamber 41.
  • the user drops the sample 7 from the negative direction side of the Z axis toward the inflow port 50.
  • the sample 7 dropped toward the inflow port 50 can flow into the storage chamber 41 from the inflow port 50.
  • the convex portion 51 is located in the substrate 5.
  • the convex portion 51 is located on the lower surface 32 of the small plate 30.
  • the convex portion 51 may be formed integrally with the small plate 30.
  • the convex portion 51 projects from the lower surface 32 of the small plate 30 which is the ceiling surface of the storage chamber 41 toward the bottom surface 41a of the space 41A of the storage chamber 41.
  • the convex portion 51 may be a substantially inverted triangle whose apex is located on the side of the bottom surface 41a of the storage chamber 41 in a cross-sectional view along the direction from the inflow port 50 toward the flow path 48.
  • the convex portion 51 limits the space in which the space on the side of the inflow port 50 of the storage chamber 41 and the space on the side of the flow path 48 of the storage chamber 41 communicate with each other to a predetermined height or less from the bottom surface of the storage chamber 41.
  • the convex portion 51 provides a space 41A in which the first chamber 42 as a space on the side of the inflow port 50 of the storage chamber 41 and the second chamber 45 as a space on the side of the flow path 48 of the storage chamber 41 communicate with each other.
  • the height is limited to a predetermined height or less from the bottom surface 41a of the storage chamber 41.
  • the sample 7 is formed between the convex portion 51 and the bottom surface 46 by the surface tension of the sample 7 in the flow path 48. It can be difficult to get wet and spread toward you. Since the sample 7 is less likely to get wet and spread toward the flow path 48, most of the sample 7 can be blocked on the side of the first chamber 42 in the storage chamber 41. Most of the sample 7 is blocked on the side of the first chamber 42 in the storage chamber 41, so that the sample 7 is before the measurement of the sample 7 by the sensor unit 6 as shown in FIG. 2 is started. The probability of flowing into the second chamber 45 of the above can be reduced.
  • the sample 7 passes through the flow path 48 before the measurement of the sample 7 by the sensor unit 6 as shown in FIG. 2 is started.
  • the probability of reaching the sensor unit 6 as shown in FIG. 2 can be reduced.
  • the liquid level of the sample 7 in the first chamber 42 can be located above the lower part of the convex portion 51.
  • the above-mentioned predetermined height may be appropriately set in consideration of the ease of wetting and spreading of the sample 7 in the storage chamber 41.
  • the predetermined height may be appropriately set based on the material of the lower substrate 40 and the surface tension of the sample 7.
  • FIG. 6 is a cross-sectional view in a state where the cartridge 4 shown in FIG. 1 is arranged in the measuring device 3.
  • FIG. 7 is a cross-sectional view of another example in a state where the cartridge 4 shown in FIG. 1 is arranged in the measuring device 3.
  • the measuring device 3 as shown in FIG. 1 includes a case 60 as shown in FIG. 6 and an air extruder 80 as shown in FIG.
  • the measuring device 3 may include a heater or a cooler for controlling the temperature of the sample 7 or the like, and a controller.
  • the controller of the measuring device 3 may be composed of a processor or a microcomputer capable of executing application software.
  • the controller of the measuring device 3 may measure the components and the like contained in the sample 7 based on the electric signal output by the sensor unit 6.
  • the case 60 as shown in FIG. 6 is arranged inside the housing 3A of the measuring device 3 as shown in FIG.
  • the case 60 may be made of a metal material, a synthetic resin material, or the like.
  • the flow path device 2 is arranged inside the case 60 as shown in FIG.
  • the case 60 has a housing 70.
  • the accommodating portion 70 is specified as an area surrounded by the wall surface 61, the wall surface 62, and the bottom surface 63.
  • the wall surface 61 and the wall surface 62 face each other.
  • the accommodating portion 70 accommodates the first spring 86, which will be described later.
  • the air extruder 80 has a syringe 81 including an upper surface 81A and a plunger 87 including a contact surface 88.
  • the measuring device 3 first pushes the upper surface 81A of the syringe 81 downward.
  • the syringe 81 is pushed down.
  • the contact surface 88 of the plunger 87 is pushed downward by the measuring device 3.
  • the plunger 87 is pushed down.
  • the configuration as shown in FIG. 7 is a configuration when the plunger 87 is pushed down in addition to the syringe 81 by the measuring device 3.
  • the measuring device 3 as shown in FIG. 1 pushes down the upper surface 81A of the syringe 81 and lowers the contact surface 88 of the plunger 87. Release the push-down.
  • the syringe 81 has a tubular shape.
  • the syringe 81 may be made of a synthetic resin material, a glass material, or the like.
  • the syringe 81 includes the top surface 81A, as described above.
  • the syringe 81 further includes a main body portion 82, an intermediate portion 83, a tip portion 84, a first seal member 85, and a first spring 86.
  • the plunger 87 is movable in the syringe 81 and can extrude the air in the syringe 81 to the tip portion 84.
  • the plunger 87 may be made of a synthetic resin material, a glass material, or the like.
  • the plunger 87 includes a contact surface 88 as described above.
  • the plunger 87 further includes a shaft portion 89, a second seal member 90, a flange portion 91, a rod-shaped portion 92, and a second spring 93.
  • the upper surface 81A faces upward. As described above, the upper surface 81A can be pushed down by the measuring device 3 as shown in FIG. The syringe 81 can be pushed down by pushing down the top surface 81A by the measuring device 3.
  • the upper surface 81A may be the upper surface of the main body 82.
  • the main body 82 may be cylindrical.
  • the main body 82 includes an inner peripheral surface 82A, a fixed surface 82B, and a lower surface 82C.
  • the inner peripheral surface 82A faces the plunger 87.
  • the fixed surface 82B faces upward.
  • the outer peripheral end of the fixed surface 82B is connected to the lower part of the inner peripheral surface 82A.
  • the fixed surface 82B comes into contact with the lower surface of the flange portion 91 of the plunger 87 when the plunger 87 is pushed down.
  • the fixing surface 82B fixes the plunger 87 by contacting the lower surface of the flange portion 91 of the plunger 87.
  • the lower surface 82C connects the outer peripheral surface of the main body 82 and the outer peripheral surface of the intermediate 83.
  • the lower surface 82C faces downward.
  • the intermediate portion 83 as shown in FIG. 6 may have a cylindrical shape.
  • the intermediate portion 83 is located between the main body portion 82 and the tip portion 84 in the direction along the Z axis.
  • the inner diameter of the intermediate portion 83 is smaller than the inner diameter of the main body portion 82.
  • the inner diameter of the intermediate portion 83 is larger than the inner diameter of the tip portion 84.
  • a first spring 86 may be arranged around the intermediate portion 83.
  • the intermediate portion 83 includes an inner peripheral surface 83A and a fixed surface 83B.
  • the inner peripheral surface 83A faces the plunger 87.
  • the upper portion of the inner peripheral surface 83A is connected to the inner peripheral end of the fixed surface 82B of the main body 82.
  • the fixed surface 83B faces upward.
  • the outer peripheral end of the fixed surface 83B is connected to the lower part of the inner peripheral surface 83A.
  • the tip portion 84 may be cylindrical.
  • the tip portion 84 can be inserted into the inflow port 50. For example, when the syringe 81 is pushed down by the measuring device 3 as shown in FIG. 1, the tip portion 84 is inserted into the inflow port 50 as shown in FIG.
  • the first seal member 85 is arranged at the tip portion 84.
  • the first seal member 85 may be an O-ring made of a soft material such as rubber.
  • the first seal member 85 may be arranged along the entire lower surface of the tip portion 84.
  • the first sealing member 85 can seal between the tip portion 84 and the storage chamber 41. For example, when the syringe 81 is pushed down, the first seal member 85 may come into contact with a portion of the upper surface 31 of the small plate 30 that surrounds the wall surface 34 of the small plate 30.
  • the first sealing member 85 seals between the tip portion 84 and the storage chamber 41 by abutting on a portion of the upper surface 31 of the small plate 30 that surrounds the wall surface 34 of the small plate 30.
  • the first spring 86 is arranged around the intermediate portion 83.
  • the first spring 86 may be a coil spring or the like.
  • the first spring 86 may be wound around the outer peripheral surface of the intermediate portion 83.
  • the first spring 86 is accommodated in the accommodating portion 70 of the case 60 when the syringe 81 is pushed down.
  • One end of the first spring 86 is fixed to the lower surface 82C of the main body 82.
  • the other end of the first spring 86 is a free end.
  • the other end of the first spring 86 is pressed against the bottom surface 63 of the accommodating portion 70 when the syringe 81 is pushed down.
  • the first spring 86 is compressed by pressing the other end of the first spring 86 against the bottom surface 63 of the accommodating portion 70.
  • the first spring 86 expands when the measuring device 3 releases the pressing of the syringe 81 onto the upper surface 81A when the measurement of the sample 7 as shown in FIG. 1 is completed.
  • the first spring 86 applies an elastic force to the syringe 81 to move the syringe 81 upward by extending the spring 86.
  • the syringe 81 moves upward after the measuring device 3 as shown in FIG. 1 releases the pressing of the syringe 81 to the upper surface 81A. Return to the position of.
  • the contact surface 88 is located above the shaft portion 89. As described above, the contact surface 88 can be pushed down by the measuring device 3 as shown in FIG. When the contact surface 88 is pushed down by the measuring device 3 as shown in FIG. 1, the plunger 87 is pushed down as shown in FIG. When the plunger 87 is pushed down, the air in the syringe 81 is sent out to the storage chamber 41 as shown in FIG. For example, when the plunger 87 is pushed down, it is interposed between the fixed surface 82B of the main body 82 and the lower surface of the flange 91 in the area surrounded by the inner peripheral surface 82A of the main body 82 as shown in FIG. The air that has been used is sent to the storage chamber 41. As will be described later, the sample 7 flows into the flow path 48 by the air sent out to the storage chamber 41 and is supplied to the sensor unit 6 as shown in FIG.
  • the contact surface 88 may be an inclined surface that is inclined in the positive direction of the Z axis with respect to the XY plane.
  • the contact surface 88 can be gradually pushed downward by the measuring device 3 as shown in FIG. By gradually pushing the contact surface 88 downward, the plunger 87 can gradually move downward. By gradually moving the plunger 87 downward, the air in the syringe 81 can be gradually delivered to the storage chamber 41.
  • the shaft portion 89 may be cylindrical.
  • the contact surface 88 is located above the shaft portion 89.
  • a flange portion 91 and a rod-shaped portion 92 are located below the shaft portion 89.
  • the second seal member 90 is arranged around the shaft portion 89.
  • the second seal member 90 may be an O-ring made of a soft material such as rubber.
  • the second seal member 90 can seal between the shaft portion 89 and the inner peripheral surface 82A of the main body portion 82.
  • the syringe 81 can be placed in a region surrounded by the inner peripheral surface 82A of the main body portion 82. Can have air.
  • the flange portion 91 is arranged at the lower part of the shaft portion 89.
  • the flange portion 91 projects from the shaft portion 89 toward the inner peripheral surface 82A of the main body portion 82. As shown in FIG. 7, the lower surface of the flange portion 91 comes into contact with the fixed surface 82B of the main body portion 82 when the plunger 87 is pushed down.
  • the rod-shaped portion 92 is located below the flange portion 91.
  • a second spring 93 is arranged around the rod-shaped portion 92.
  • the second spring 93 may be a coil spring or the like.
  • the second spring 93 may be wound around the outer peripheral surface of the rod-shaped portion 92.
  • One end of the second spring 93 is fixed to the lower part of the flange portion 91.
  • the other end of the second spring 93 is fixed to the fixing surface 83B of the intermediate portion 83. As shown in FIG.
  • the distance between the lower surface of the flange portion 91 and the fixed surface 83B of the intermediate portion 83 is the distance between the lower surface of the flange portion 91 and the intermediate portion 83 as shown in FIG. It is shorter than the distance to the fixed surface 83B.
  • the second spring 93 is compressed by shortening the distance between the lower surface of the flange portion 91 and the fixed surface 83B of the intermediate portion 83. The second spring 93 expands when the measurement device 3 as shown in FIG. 1 releases the push-down to the contact surface 88 when the measurement of the sample 7 as shown in FIG. 1 is completed.
  • the second spring 93 applies an elastic force that moves the plunger 87 upward by extending the spring 93.
  • the plunger 87 is pushed up after the measuring device 3 as shown in FIG. 1 releases the push-down to the contact surface 88.
  • the user drops the sample 7 toward the inflow port 50 of the flow path device 2.
  • the sample 7 dropped toward the inflow port 50 is stored in the storage chamber 41.
  • Most of the sample 7 can be blocked by the convex portion 51 on the side of the first chamber 42 in the storage chamber 41, as described above with reference to FIG. Since most of the sample 7 is blocked on the side of the first chamber 42 in the storage chamber 41, the probability that the sample 7 will flow into the second chamber 45 of the storage chamber 41 can be reduced.
  • by connecting the flow path 48 to the upper part of the storage chamber 41 the probability that the sample 7 accumulated under the storage chamber 41 will flow into the flow path 48 is reduced. Can be done.
  • the user drops the sample 7 toward the inflow port 50 of the flow path device 2, and then inserts the cartridge 4 provided with the flow path device 2 into the insertion port 3B of the measuring device 3 as shown in FIG.
  • the cartridge 4 inserted from the insertion port 3B of the measuring device 3 as shown in FIG. 1 is arranged inside the case 60 as shown in FIG.
  • the measuring device 3 as shown in FIG. 1 pushes down the upper surface 81A of the syringe 81 as shown in FIG.
  • the syringe 81 moves downward.
  • the tip 84 of the syringe 81 is inserted into the inflow port 50 of the flow path device 2 as shown in FIG.
  • the sample 7 in the second chamber 45 flows out to the flow path 48.
  • the sample 7 flowing out to the flow path 48 reaches the sensor unit 6 as shown in FIG. 2 via the flow path 48.
  • the sensor unit 6 outputs an electric signal corresponding to the component contained in the sample 7 to the controller of the measuring device 3 as shown in FIG.
  • the bottom surface 46 may be an inclined surface that is inclined from the bottom surface 41a of the space 41A toward the flow path 48. Since the bottom surface 46 is an inclined surface inclined toward the flow path 48, the sample 7 can smoothly flow from the second chamber 45 toward the flow path 48.
  • the plunger 87 moves downward until the lower surface of the flange portion 91 of the plunger 87 abuts on the fixed surface 82B of the syringe 81.
  • the air from the air extruder 80 passes below the convex portion 51.
  • the air passing below the convex portion 51 pushes the sample 7 in the second chamber 45 in the positive direction of the X-axis.
  • the convex portion 51 may be a substantially inverted triangle whose apex is located on the side of the bottom surface 41a of the storage chamber 41 in a cross-sectional view.
  • the convex portion 51 has a substantially inverted triangle shape, the air flowing through the upper part of the first chamber 42 of the storage chamber 41 can be smoothly guided below the convex portion 51 by the slope of the convex portion 51. Since the air is smoothly guided below the convex portion 51 by the slope of the convex portion 51, the air can efficiently push the sample 7 in the second chamber 45 to the positive direction side of the X axis.
  • the measuring device 3 as shown in FIG. 1 pushes the syringe 81 down to the upper surface 81A as shown in FIG. 7 and pushes it down to the contact surface 88 of the plunger 87 as shown in FIG. Release the push-down.
  • the syringe 81 can be returned to the original position by the first spring 86 as shown in FIG. 7 as described above.
  • the plunger 87 can be returned to the original position by the second spring 93 as shown in FIG. 7.
  • the flow path device 2 since the flow path device 2 according to the present embodiment includes the convex portion 51, the timing of supplying the sample 7 to the sensor unit 6 can be easily controlled as described below. ..
  • FIG. 10 is a cross-sectional view of the measurement system 1X according to the comparative example.
  • the measurement system 1X includes a flow path device 2X. Unlike the flow path device 2 as shown in FIG. 6, the flow path device 2X does not have a convex portion 51.
  • the sample 7 can spread over the entire bottom surface of the storage chamber 41.
  • the flow path 48 is connected to the upper part of the storage chamber 41 in order to reduce the probability that the sample 7 accumulated under the storage chamber 41 will flow into the flow path 48.
  • the liquid level of the sample 7 in the first chamber 42 can be located above the lower part of the convex portion 51. Since the liquid level of the sample 7 in the first chamber 42 is located above the lower part of the convex portion 51, the space portion of the first chamber 42 above the liquid level of the sample 7 except for the inflow port 50. It can be a closed space. With such a configuration, the air flowing in from the inflow port 50 can surely push the liquid level of the sample 7 in the first chamber 42 downward as shown in FIG. By pushing the liquid level of the sample 7 in the first chamber 42 downward, as described above with reference to FIG. 9, the sample 7 reaches the sensor unit 6 as shown in FIG. 2 via the flow path 48. be able to.
  • the flow path device 2 and the measurement system 1 that can easily control the timing of supplying the sample 7 to the sensor unit 6 can be provided.
  • air can be sent out from above the flow path device 2 to the storage chamber 41 by the air extruder 80.
  • the flow path device 2 does not need to be provided with a mechanism for sending air to the storage chamber 41 at a location different from that of the storage chamber 41.
  • the size of the flow path device 2 in the XY plane can be reduced. By reducing the size of the flow path device 2 in the XY plane, most of the flow path device 2 can be accommodated inside the measuring device 3 as shown in FIG. By accommodating most of the flow path device 2 inside the measuring device 3, the sample 7 arranged in the flow path device 2 can be heated more efficiently. By heating the sample 7 more efficiently, the measurement system 1 can measure the components of the sample 7 more accurately.
  • the lower surface 32 of the small plate 30 can be used as the ceiling surface of the storage chamber 41.
  • the small plate 30 is a component separate from the lower substrate 40 on which the bottom surfaces 43, 46 and the wall surfaces 44, 45 of the storage chamber 41 are formed.
  • the storage chamber 41 is less affected by the surface accuracy. Since the storage chamber 41 is less affected by the surface accuracy, the airtightness of the storage chamber 41 can be improved.
  • one end of the first spring 86 as shown in FIG. 6 has been described as being fixed to the lower surface 82C of the main body 82 of the syringe 81.
  • one end of the first spring 86 does not have to be fixed to the lower surface 82C.
  • the first spring 86 may be arranged around the syringe 81.
  • one end of the second spring 93 as shown in FIG. 6 has been described as being fixed to the lower portion of the flange portion 91. Further, the other end of the second spring 93 has been described as being fixed to the fixing surface 83B of the intermediate portion 83. However, one end of the second spring 93 does not have to be fixed to the lower part of the flange portion 91. Further, the other end of the second spring 93 does not have to be fixed to the fixing surface 83B of the intermediate portion 83.
  • the second spring 93 may be arranged around the rod-shaped portion 92 of the plunger 87.
  • the convex portion 51 as shown in FIG. 3 limits the space 41A to a predetermined height or less from the bottom surface 41a of the storage chamber 41.
  • the predetermined height may be appropriately set in consideration of the ease of wetting and spreading of the sample 7 in the storage chamber 41.
  • the setting of the predetermined height is not limited to this.
  • the predetermined height may be set so that the liquid level of the sample 7 in the first chamber 42 is located above the lower portion of the convex portion 51.
  • the flow path device 102 as shown in FIG. 11 includes a convex portion 151. Similar to the convex portion 51 as shown in FIG.
  • the convex portion 151 limits the space 41A to a predetermined height or less from the bottom surface 41a of the storage chamber 41.
  • the predetermined height is set so that the liquid level of the sample 7 in the first chamber 42 is located above the lower portion of the convex portion 151.
  • the predetermined height may be calculated based on the total bottom area of the storage chamber 41 and the assumed amount of the sample 7.
  • the predetermined height is set so that the liquid level of the sample 7 in the first chamber 42 is located above the lower portion of the convex portion 151.
  • the space portion above the liquid level of the sample 7 in the first chamber 42, except for the inflow port 50 is similar to the configuration shown in FIG. It can be a closed space.
  • the space above the liquid level of the sample 7 in the first chamber 42 becomes a closed space except for the inflow port 50, so that the flow path device 102 can be used as described above with reference to FIG.
  • the air flowing in from the inflow port 50 can surely push the liquid level of the sample 7 in the first chamber 42 downward.
  • in the flow path device 102 by pushing the liquid level of the sample 7 in the first chamber 42 downward, the sample 7 passes through the flow path 48 and is as shown in FIG.
  • the sensor unit 6 can be reached.
  • the descriptions such as “first” and “second” are identifiers for distinguishing the configuration.
  • the configurations distinguished by the descriptions such as “first” and “second” in the present disclosure can exchange numbers in the configurations.
  • the first room can exchange the identifiers “first” and “second” with the second room.
  • the exchange of identifiers takes place at the same time.
  • the configuration is distinguished.
  • the identifier may be deleted.
  • the configuration with the identifier removed is distinguished by a code. Based solely on the description of identifiers such as “first” and “second” in the present disclosure, it shall not be used as a basis for interpreting the order of the configurations and for the existence of identifiers with smaller numbers.

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PCT/JP2020/017540 2019-04-25 2020-04-23 流路デバイス、カートリッジ及び測定システム Ceased WO2020218439A1 (ja)

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EP20795032.0A EP3961226A4 (en) 2019-04-25 2020-04-23 FLOW PATH DEVICE, CARTRIDGE AND MEASUREMENT SYSTEM
CN202080030647.2A CN113728235A (zh) 2019-04-25 2020-04-23 流路设备、载盒和测量系统
US17/605,989 US20220212474A1 (en) 2019-04-25 2020-04-23 Flow path device, cartridge, and measurement system
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Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03102250U (https=) * 1990-02-05 1991-10-24
JP2000055911A (ja) * 1998-07-20 2000-02-25 Lifescan Inc 医療診断用流体器具
JP2002224090A (ja) 2001-02-07 2002-08-13 Tya:Kk 体液成分の検査方法及びこれに用いる検査器具
JP2002527250A (ja) * 1998-10-13 2002-08-27 バイオマイクロ システムズ インコーポレイテッド 受動流体力学に基づく流体回路構成要素
WO2008105308A1 (ja) * 2007-02-27 2008-09-04 Konica Minolta Holdings, Inc. 流路切換システム
WO2015099162A1 (ja) * 2013-12-26 2015-07-02 京セラ株式会社 検体液センサ、検体液センサユニット及び検体液検査方法
WO2016002847A1 (ja) * 2014-07-01 2016-01-07 株式会社ニコン 流体デバイス、流体の制御方法、検査デバイス、検査方法、及び流体デバイスの製造方法
JP2017096640A (ja) * 2015-11-18 2017-06-01 アイシン精機株式会社 マイクロ流体デバイス、撹拌システム、及び、分析装置
JP2017523433A (ja) * 2014-08-08 2017-08-17 オーソ−クリニカル・ダイアグノスティックス・インコーポレイテッドＯｒｔｈｏ−Ｃｌｉｎｉｃａｌ Ｄｉａｇｎｏｓｔｉｃｓ， Ｉｎｃ． 流動狭窄部を有するラテラルフローアッセイデバイス
JP2018059916A (ja) * 2016-09-30 2018-04-12 積水化学工業株式会社 マイクロ流路チップ

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922604A (en) * 1997-06-05 1999-07-13 Gene Tec Corporation Thin reaction chambers for containing and handling liquid microvolumes
US20040042930A1 (en) * 2002-08-30 2004-03-04 Clemens Charles E. Reaction chamber with capillary lock for fluid positioning and retention
TW200506364A (en) * 2003-04-09 2005-02-16 Effector Cell Inst Inc Apparatus for detecting cell chemo-taxis
JP4721414B2 (ja) * 2005-08-15 2011-07-13 キヤノン株式会社 反応カートリッジ、反応装置および反応カートリッジの溶液の移動方法
JP4755942B2 (ja) * 2006-06-02 2011-08-24 芝浦メカトロニクス株式会社 基板の処理装置
JP5137551B2 (ja) * 2006-12-28 2013-02-06 キヤノン株式会社 生化学反応カセット
JP5088193B2 (ja) * 2007-10-16 2012-12-05 セイコーエプソン株式会社 液体収容容器
BRPI0907148B1 (pt) * 2008-02-27 2021-01-12 Boehringer Ingelheim Microparts Gmbh dispositivo para a separação do plasma
EP3236260B1 (en) * 2011-04-13 2020-09-30 Akonni Biosystems, Inc. Method for making a microarray assembly
WO2014070235A1 (en) * 2012-10-29 2014-05-08 Mbio Diagnostics, Inc. Biological particle identification system, cartridge and associated methods
EP2944940B1 (en) * 2013-01-08 2020-07-08 Musashi Engineering, Inc. Aid for filling liquid, and method for filling liquid
JP6665548B2 (ja) * 2015-03-06 2020-03-13 ソニー株式会社 マイクロチップ、並びに分析装置及び分析方法
EP3429543B1 (en) * 2016-03-14 2024-11-20 Pfizer Inc. Selectively vented biological assay devices and associated methods
JP6419130B2 (ja) * 2016-10-31 2018-11-07 シスメックス株式会社 測定用カートリッジおよび送液方法

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03102250U (https=) * 1990-02-05 1991-10-24
JP2000055911A (ja) * 1998-07-20 2000-02-25 Lifescan Inc 医療診断用流体器具
JP2002527250A (ja) * 1998-10-13 2002-08-27 バイオマイクロ システムズ インコーポレイテッド 受動流体力学に基づく流体回路構成要素
JP2002224090A (ja) 2001-02-07 2002-08-13 Tya:Kk 体液成分の検査方法及びこれに用いる検査器具
WO2008105308A1 (ja) * 2007-02-27 2008-09-04 Konica Minolta Holdings, Inc. 流路切換システム
WO2015099162A1 (ja) * 2013-12-26 2015-07-02 京セラ株式会社 検体液センサ、検体液センサユニット及び検体液検査方法
WO2016002847A1 (ja) * 2014-07-01 2016-01-07 株式会社ニコン 流体デバイス、流体の制御方法、検査デバイス、検査方法、及び流体デバイスの製造方法
JP2017523433A (ja) * 2014-08-08 2017-08-17 オーソ−クリニカル・ダイアグノスティックス・インコーポレイテッドＯｒｔｈｏ−Ｃｌｉｎｉｃａｌ Ｄｉａｇｎｏｓｔｉｃｓ， Ｉｎｃ． 流動狭窄部を有するラテラルフローアッセイデバイス
JP2017096640A (ja) * 2015-11-18 2017-06-01 アイシン精機株式会社 マイクロ流体デバイス、撹拌システム、及び、分析装置
JP2018059916A (ja) * 2016-09-30 2018-04-12 積水化学工業株式会社 マイクロ流路チップ

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP3961226A4

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EP3961226A1 (en) 2022-03-02
US20220212474A1 (en) 2022-07-07
CN113728235A (zh) 2021-11-30
EP3961226A4 (en) 2023-02-15
JPWO2020218439A1 (https=) 2020-10-29

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