WO2020206965A1 - 一种体液收集和检测装置 - Google Patents

一种体液收集和检测装置 Download PDF

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Publication number
WO2020206965A1
WO2020206965A1 PCT/CN2019/110909 CN2019110909W WO2020206965A1 WO 2020206965 A1 WO2020206965 A1 WO 2020206965A1 CN 2019110909 W CN2019110909 W CN 2019110909W WO 2020206965 A1 WO2020206965 A1 WO 2020206965A1
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Prior art keywords
receiving tube
detection
outer cylinder
sample
body fluid
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PCT/CN2019/110909
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English (en)
French (fr)
Inventor
陆维克
高飞
王海剑
刘成
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杭州奥泰生物技术股份有限公司
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Publication of WO2020206965A1 publication Critical patent/WO2020206965A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Definitions

  • the utility model belongs to the technical field of fluid detection, in particular to a body fluid collection and detection device.
  • saliva samples Due to the particularity of saliva samples, it is inconvenient to store them, and they are generally used as they are. It can also ensure that the samples are not contaminated or exchanged, which will affect the test results.
  • the device has the characteristics of convenient carrying, tiny structure, simple and fast operation, and complete detection items. This kind of rapid detection of multiple items at a time can be widely used in the field of rapid fluid detection, such as drug abuse detection, rapid drug detection, etc., and is widely used in hospitals, drug rehabilitation centers, physical examination centers and other places.
  • the purpose of the utility model is to provide a body fluid collection and detection device.
  • the utility model includes a sampling part and a detection part.
  • the sampling part includes a sample collecting rod and a sample receiving tube.
  • a sampling head is arranged at the bottom end of the sample collecting rod.
  • the sampling head at the bottom of the sample collecting rod is located in the sample receiving tube.
  • the bottom of the sample receiving tube is provided with a drainage opening.
  • the detection part includes a detection reagent strip, a carrier plate and an outer cylinder body.
  • the sample receiving tube is located in the outer cylinder body.
  • the bottom of the inner cavity of the outer cylinder body is provided with a detection groove.
  • the carrier plate is arranged on the outer cylinder body.
  • a plurality of vertical test paper placement grooves are opened on the carrier plate.
  • a test reagent strip is arranged in the test paper placement groove. The bottom ends of all test reagent strips are in contact with the bottom of the test groove.
  • a support plate is provided at the bottom of the inner cavity of the outer cylinder body.
  • the support plate is set up obliquely as a whole.
  • the supporting plate is provided with a receiving tube supporting section and a body fluid flow channel.
  • the bottom end of the body fluid channel is located directly above the middle of the detection groove.
  • the bottom end of the sample receiving tube is in contact with the receiving tube support section of the support plate.
  • the drainage opening at the bottom of the sample receiving tube is aligned with the top of the body fluid channel on the support plate.
  • the sample collection rod includes a screw cap, a connecting rod and a sampling head.
  • the top end of the connecting rod is fixed with the inner cavity of the screw cap, and the bottom end is fixed with the sampling head.
  • the sample receiving tube includes an integrally formed external threaded tube, a connecting cover, a receiving tube body and a support bar.
  • the external threaded tube, the connecting cover and the receiving tube body are arranged and connected in sequence.
  • the external threaded tube communicates with the inner cavity of the receiving tube body.
  • the bottom of the receiving tube body is provided with an extrusion bottom plate.
  • the receiving tube body includes a transition section, a guide section, and an extrusion section that are connected sequentially from top to bottom, and whose inner diameter is sequentially reduced. Ventilation holes are provided at the transition section.
  • the inner diameter of the extrusion section is smaller than the diameter of the sampling head.
  • the internal thread on the screw cap is threadedly connected with the external thread on the external threaded tube.
  • the two support bars on the sample receiving tube respectively contact the inner sides of the two carrier plates.
  • a connecting cover is provided on the sample receiving tube.
  • the bottom surface of the connecting cover is provided with an annular groove.
  • the top end of the outer cylinder body is open and is provided with an annular protrusion. The cross-sectional shapes of the annular groove and the annular protrusion correspond to each other.
  • the outer peripheral side wall of the outer cylinder body there are two flat display panels on the outer peripheral side wall of the outer cylinder body.
  • the bottom ends of the inner sides of the two flat display panels are both connected with the detection groove.
  • the two carrier plates are in contact with the inner sides of the two flat display plates respectively.
  • the target test substances of the test reagent strips on the two carrier plates are different.
  • each test paper placement groove is provided with reinforcement bumps.
  • sampling head uses water-absorbing materials.
  • the outer cylinder body is made of transparent material.
  • the utility model directly sucks the sample through the sampling head; after sampling, the sampling head is inserted into the sample receiving tube and then tightened to automatically start the detection, and the operation is very convenient.
  • the detection groove in the present invention is a slender V shape, so only a small amount of samples can meet the detection requirements of the detection reagent strip, which greatly improves the efficiency and accuracy of detection.
  • the utility model can simultaneously perform the detection of multiple items for the same sample, and the detection results can be displayed intuitively.
  • the whole structure of the utility model is very stable by arranging support bars and carrier plates.
  • Figure 1 is a schematic diagram of the overall structure of the utility model
  • Figure 2 is an internal schematic diagram of the utility model
  • Figure 3 is an exploded view of the utility model
  • Figure 4 is a schematic diagram of the sample receiving tube in the utility model
  • Figure 5 is a top view of the Chinese and foreign cylinders of the utility model
  • Figure 6 is a cross-sectional view of the utility model.
  • a body fluid collection and detection device includes a sampling part 1 and a detection part 2.
  • the sampling part 1 includes a sample collecting rod 11 and a sample receiving tube 12.
  • the sample collection rod 11 includes a screw cap 111, a connecting rod 112 and a sampling head 113.
  • the top end of the connecting rod 112 is fixed to the inner cavity of the screw cap 111, and the bottom end is fixed to the sampling head 113.
  • the sampling head 113 is made of water-absorbing material, preferably sponge.
  • the sample receiving tube 12 includes an integrally formed externally threaded tube 121, a connecting cover 122, a receiving tube body 123 and a support bar 124.
  • the externally threaded tube 121, the connecting cover 122, and the receiving tube body 123 are connected in sequence.
  • the externally threaded tube 121 communicates with the inner cavity of the receiving tube body 123.
  • An extrusion bottom plate 125 is provided at the bottom of the receiving tube body 123.
  • the bottom end of the side surface of the receiving tube 123 is provided with a drainage opening 126.
  • the receiving tube body 123 includes a transition section, a guide section, and an extrusion section that are sequentially connected from top to bottom and whose inner diameter is reduced in sequence.
  • Ventilation holes are provided at the transition section.
  • the inner diameter of the transition section is equal to the diameter of the sampling head 113.
  • the air vent can make the air pressure at both ends of the sampling head 113 equal when sliding in the receiving tube body 123, thereby making the removal and installation of the sampling head 113 more convenient.
  • the inner diameter of the extrusion section is smaller than the diameter of the sampling head 113. Therefore, when the sampling head 113 enters the squeezing section, it will be subjected to a squeezing force in the radial direction, thereby causing compression deformation.
  • the internal thread on the screw cap 111 is threadedly connected with the external thread on the external threaded tube 121.
  • the connecting rod 112 and the sampling head 113 are both located in the receiving tube body 123.
  • the distance from the top surface of the connecting cap 122 to the pressing bottom plate 125 on the receiving tube body 123 is greater than the distance from the bottom end of the screw cap 111 to the bottom end of the connecting rod 112, and is less than the distance from the bottom end of the screw cap 111 to the bottom end of the undeformed sampling head 113 distance. (That is, when the screw cap 111 is tightened with the external threaded tube 121, the sampling head 113 is squeezed by the pressing bottom plate 125 to deform).
  • the detection part 2 includes a detection reagent strip 21, a carrier plate 22 and an outer cylinder body 23.
  • the outer cylinder body 23 adopts a transparent material.
  • a V-shaped detection groove 231 is provided at the bottom of the inner cavity of the outer cylinder body 23. The bottom ends of the inner sides of the two flat display panels are both connected with the detection groove 231.
  • two carrier plates 22 are both arranged in the outer cylinder body 23 and respectively contact the inner sides of the two flat display plates.
  • a plurality of vertically arranged test paper placement grooves are opened on both of the two carrier plates 22.
  • a test reagent strip 21 is provided in each test paper placement groove.
  • the top and bottom ends of each test paper placement groove are provided with reinforcement bumps.
  • the reinforcement bump is used to fix the detection reagent strip 21 more firmly.
  • the bottom ends of all detection reagent strips 21 are in contact with the bottom of the detection groove 231.
  • the detection reagent strips 21 on the two carrier plates 22 have different target detection objects (that is, the detection reagent strips 21 on the two carrier plates 22 can detect two different items respectively).
  • the top of the outer cylinder body 23 is open and is provided with an annular protrusion.
  • the bottom surface of the connecting cover 122 of the sample receiving tube 12 is provided with an annular groove.
  • the cross-sectional shapes of the annular groove and the annular protrusion correspond to each other.
  • the annular protrusion is clamped into the annular groove, so that the sample receiving tube 12 and the outer cylinder body 23 are fixed to each other, and the connecting cover 122 seals the top opening of the outer cylinder body 23.
  • the receiving tube body 123 of the sample receiving tube 12 is arranged on the outer cylinder body 23.
  • the two support bars 124 on the sample receiving tube 12 are in contact with the inner sides of the two carrier plates 22 respectively. While supporting the carrier plate 22 by the two support bars 124, it can also make the sample receiving tube 12 more stable.
  • the bottom of the inner cavity of the outer cylinder body 23 is provided with a supporting plate.
  • the support plate is set up obliquely as a whole.
  • the support plate is provided with a receiving tube support section 232 and a body fluid flow channel 233.
  • the bottom end of the body fluid channel 233 is located directly above the middle of the detection groove 231 (that is, the bottom end where the two carrier plates 22 are connected).
  • the pressing bottom plate 125 at the bottom end of the sample receiving tube 12 is in contact with the receiving tube support section 232 of the support plate.
  • the drainage opening 126 at the bottom end of the sample receiving tube 12 is aligned with the top end of the body fluid channel 233 on the support plate.
  • the user rotates the screw cap 111, takes out the sample collection rod 11, and extends the sampling head 113 on the sample collection rod 11 into the oral cavity of the subject. After the subject's saliva sufficiently wets the sampling head, the sample collection rod 11 is inserted into the sample receiving tube 12. Tighten the screw cap 111 so that the sampling head 113 is compressed in the radial direction under the action of the squeezing section at the bottom of the sample receiving tube 12, and compressed in the axial direction under the action of the squeezing bottom plate 125 of the sample receiving tube 12, so that the sampling head The saliva sample is fully squeezed out. The extruded saliva sample flows out from the drainage opening 126 and enters the detection groove 231 through the body fluid flow channel 233 to contact the detection reagent strip 21.
  • the body fluid channel 233 can effectively guide the extruded saliva sample to the elongated detection groove 231.
  • the detection groove 231 is in the shape of an elongated V, only a small amount of saliva samples can meet the detection requirements of the detection reagent strip, which greatly improves the efficiency and accuracy of detection.
  • test results of each test reagent strip After standing for 5 minutes, the user can observe the test results of each test reagent strip through two transparent flat display panels.

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  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
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Abstract

一种体液收集和检测装置，包括取样部分（1）和检测部分（2）；取样部分（1）包括样本采集棒（11）和样本接收管（12）；样本采集棒（11）的底端设置有取样头（113）；取样头（113）位于样本接收管（12）内；样本接收管（12）的底部开设有引流开口（126）；检测部分（2）包括检测试剂条（21）、载体板（22）和外筒身（23）；样本接收管（12）位于外筒身（23）内；外筒身（23）的内腔底部设置有检测沟槽（231）；载体板（22）设置在外筒身（23）内；载体板（22）上开设有多根竖直试纸安置槽；试纸安置槽内设置有检测试剂条（21）；所有检测试剂条（21）的底端均与检测沟槽（231）的底部接触。通过取样头（113）直接吸取样本；取样后将取样头（113）插入样本接收管（12）后旋紧即可自动开始检测，操作十分方便。

Description

一种体液收集和检测装置 技术领域
本实用新型属于流体检测技术领域，具体涉及一种体液收集和检测装置。
背景技术
由于唾液样本的特殊性，不便储存，一般都是现取现用，也能保证样本不被污染或调换，从而影响检测结果。
因此，提供了一种可以收集唾液样本并同时检测的装置，本装置具有携带方便、结构精巧、操作简单快速、检测项目种类齐全等特点。这种一次可同时快速检测多个项目，能广泛运用于流体快速检测领域，如药物滥用检测、毒品快速检测领域等，被大量用于医院、戒毒所、体检中心等场所。
发明内容
本实用新型的目的在于提供一种体液收集和检测装置。
本实用新型包括取样部分和检测部分。所述的取样部分包括样本采集棒和样本接收管。所述的样本采集棒的底端设置有取样头。样本采集棒的底端的取样头位于样本接收管内。样本接收管的底部开设有引流开口。
所述的检测部分包括检测试剂条、载体板和外筒身。样本接收管位于外筒身内。外筒身的内腔底部设置有检测沟槽。载体板设置在外筒身。载体板上开设有多根竖直设置试纸安置槽。试纸安置槽内设置有检测试剂条。所有检测试剂条的底端均与检测沟槽的底部接触。
进一步地，所述外筒身内腔的底部设置有支撑板。支撑板整体倾斜设置。支撑板上设置有接收管支撑段和体液流道。体液流道的底端位于检测沟槽中部的正上方。样本接收管的底端与支撑板的接收管支撑段接触。样本接收管底端的引流开口与支撑板上体液流道的顶端对齐。
进一步地，所述的样本采集棒包括螺旋盖、连接杆和取样头。连接杆的顶端与螺旋盖的内腔固定，底端与取样头固定。所述的样本接收管包括一体成型的外螺纹管、连接盖、接收管身和支撑条。外螺纹管、连接盖、接收管身依次排列相连。外螺纹管与接收管身的内腔连通。接收管身的底部设置有挤压底板。接收管身包括由上至下依次连接，且内径依 次缩小的过渡段、导向段和挤压段。过渡段处设置有通气孔。挤压段的内径小于取样头的直径。螺旋盖上的内螺纹与外螺纹管上的外螺纹螺纹连接。样本接收管上的两根支撑条分别与两块载体板的内侧面接触。
进一步地，所述的样本接收管上设置有连接盖。连接盖底面设置有环形凹槽。所述外筒身的顶端开放设置，且设置有环形凸起。环形凹槽与环形凸起的横截面形状相互对应。
进一步地，所述外筒身的外周侧壁上有两块平面显示板。两块平面显示板内侧面的底端均与检测沟槽连接。载体板共有两块。两块载体板与两块平面显示板的内侧面分别接触。两块载体板上的检测试剂条的目标检测物不相同。
进一步地，各试纸安置槽的顶端和底端均设置有加固凸块。
进一步地，所述的取样头采用吸水材料。所述的外筒身采用透明材料。
本实用新型具有的有益效果是：
1、本实用新型通过取样头直接吸取样本；取样后将取样头插入样本接收管后旋紧即可自动开始检测，操作十分方便。
2、本实用新型中的检测沟槽呈细长的V形，故只需少量的样本即可满足检测试剂条的检测要求，这大大提高了检测的效率和精准程度。
3、本实用新型能够针对同一样本同时进行多个项目的检测，且检测结果能够直观显示出来。
4、本实用新型通过设置支撑条、载体板，整体结构十分稳固。
附图说明
图1为本实用新型的整体结构示意图；
图2为本实用新型的内部示意图；
图3为本实用新型的爆炸图；
图4为本实用新型中样本接收管的示意图；
图5为本实用新型中外筒身的俯视图；
图6为本实用新型的剖视图。
具体实施方式
以下结合附图对本实用新型作进一步说明。
如图1、2和3所示，一种体液收集和检测装置，包括取样部分1和检测部分2。取样部分1包括样本采集棒11和样本接收管12。样本采集棒11包括螺旋盖111、连接杆112 和取样头113。连接杆112的顶端与螺旋盖111的内腔固定，底端与取样头113固定。取样头113采用吸水材料，优选海绵。
如图2、3和4所示，样本接收管12包括一体成型的外螺纹管121、连接盖122、接收管身123和支撑条124。外螺纹管121、连接盖122、接收管身123依次排列相连。外螺纹管121与接收管身123的内腔连通。接收管身123的底部设置有挤压底板125。接收管身123侧面的底端开设有引流开口126。接收管身123包括由上至下依次连接，且内径依次缩小的过渡段、导向段和挤压段。过渡段处设置有通气孔。过渡段的内径等于取样头113的直径。通气孔能够让取样头113在接收管身123中滑动时两端的气压相等，进而使得取样头113的取出和装入更加便捷。挤压段的内径小于取样头113的直径。因此，当取样头113进入挤压段时，将受到沿径向的挤压力，从而发生压缩变形。
螺旋盖111上的内螺纹与外螺纹管121上的外螺纹螺纹连接。连接杆112及取样头113均位于接收管身123内。连接盖122顶面到接收管身123上的挤压底板125的距离大于螺旋盖111的底端到连接杆112底端的距离，且小于螺旋盖111的底端到未变形的取样头113底端的距离。(即当螺旋盖111与外螺纹管121旋紧时，取样头113被挤压底板125挤压发生变形)。
如图1、2、3、5和6所示，检测部分2包括检测试剂条21、载体板22和外筒身23。外筒身23采用透明材料。外筒身23的外周侧壁上有两块平面显示板。两块平面显示板组成在一起呈V形。外筒身23的内腔底部设置有呈V形的检测沟槽231。两块平面显示板内侧面的底端均与检测沟槽231连接。
如图2、3和6所示，两块载体板22均设置在外筒身23内，且与两块平面显示板的内侧面分别接触。两块载体板22上均开设有多根竖直设置试纸安置槽。各试纸安置槽内均设置有检测试剂条21。各试纸安置槽的顶端和底端均设置有加固凸块。加固凸块用于更加稳固的固定检测试剂条21。所有检测试剂条21的底端均与检测沟槽231的底部接触。两块载体板22上的检测试剂条21的目标检测物不相同(即两块载体板22上的检测试剂条21能够分别检测两个不相同的项目)。
外筒身23的顶端开放设置，且设置有环形凸起。样本接收管12的连接盖122底面设置有环形凹槽。环形凹槽与环形凸起的横截面形状相互对应。环形凸起卡入环形凹槽内，使得样本接收管12与外筒身23相互固定，且连接盖122封住外筒身23的顶部开口。使得样本接收管12的接收管身123设置在外筒身23。样本接收管12上的两根支撑条124分别 与两块载体板22的内侧面接触。两根支撑条124的支撑载体板22的同时，也能够使得样本接收管12更加稳固。
外筒身23内腔的底部设置有支撑板。支撑板整体倾斜设置。支撑板上设置有接收管支撑段232和体液流道233。体液流道233的底端位于检测沟槽231中部(即两块载体板22连接处的底端)的正上方。样本接收管12底端的挤压底板125与支撑板的接收管支撑段232接触。样本接收管12底端的引流开口126与支撑板上体液流道233的顶端对齐。
本实用新型的工作原理如下：
使用者旋转螺旋盖111，取出样本采集棒11，并将样本采集棒11上的取样头113伸入受试者口腔中。受试者的唾液充分润湿取样头后，样本采集棒11插入样本接收管12中。旋紧螺旋盖111，使得取样头113在样本接收管12底部的挤压段的作用下沿径向压缩，在样本接收管12的挤压底板125的作用下沿轴向压缩，从而让取样头上的唾液样本被充分挤出。被挤出的唾液样本从引流开口126流出，经体液流道233进入检测沟槽231中与检测试剂条21接触。体液流道233能使得被挤出的唾液样本被有效引导至细长的检测沟槽231处。又由于检测沟槽231呈细长的V形，故只需少量的唾液样本即可满足检测试剂条的检测要求，这大大提高了检测的效率和精准程度。
静置5分钟后，使用者即可通过透明地两块平面显示板观察各检测试剂条的检测结果。

Claims (7)

  1. 一种体液收集和检测装置，包括取样部分和检测部分；其特征在于：所述的取样部分包括样本采集棒和样本接收管；所述的样本采集棒的底端设置有取样头；样本采集棒的底端的取样头位于样本接收管内；样本接收管的底部开设有引流开口；
    所述的检测部分包括检测试剂条、载体板和外筒身；样本接收管位于外筒身内；外筒身的内腔底部设置有检测沟槽；载体板设置在外筒身；载体板上开设有多根竖直设置试纸安置槽；试纸安置槽内设置有检测试剂条；所有检测试剂条的底端均与检测沟槽的底部接触。
  2. 根据权利要求1所述的一种体液收集和检测装置，其特征在于：所述外筒身内腔的底部设置有支撑板；支撑板整体倾斜设置；支撑板上设置有接收管支撑段和体液流道；体液流道的底端位于检测沟槽中部的正上方；样本接收管的底端与支撑板的接收管支撑段接触；样本接收管底端的引流开口与支撑板上体液流道的顶端对齐。
  3. 根据权利要求1所述的一种体液收集和检测装置，其特征在于：所述的样本采集棒包括螺旋盖、连接杆和取样头；连接杆的顶端与螺旋盖的内腔固定，底端与取样头固定；所述的样本接收管包括一体成型的外螺纹管、连接盖、接收管身和支撑条；外螺纹管、连接盖、接收管身依次排列相连；外螺纹管与接收管身的内腔连通；接收管身的底部设置有挤压底板；接收管身包括由上至下依次连接，且内径依次缩小的过渡段、导向段和挤压段；过渡段处设置有通气孔；挤压段的内径小于取样头的直径；螺旋盖上的内螺纹与外螺纹管上的外螺纹螺纹连接；样本接收管上的两根支撑条分别与两块载体板的内侧面接触。
  4. 根据权利要求1所述的一种体液收集和检测装置，其特征在于：所述的样本接收管上设置有连接盖；连接盖底面设置有环形凹槽；所述外筒身的顶端开放设置，且设置有环形凸起；环形凹槽与环形凸起的横截面形状相互对应。
  5. 根据权利要求1所述的一种体液收集和检测装置，其特征在于：所述外筒身的外周侧壁上有两块平面显示板；两块平面显示板内侧面的底端均与检测沟槽连接；载体板共有两块；两块载体板与两块平面显示板的内侧面分别接触；两块载体板上的检测试剂条的目标检测物不相同。
  6. 根据权利要求1所述的一种体液收集和检测装置，其特征在于：各试纸安置槽的顶端和底端均设置有加固凸块。
  7. 根据权利要求1所述的一种体液收集和检测装置，其特征在于：所述的取样头采用吸水材料；所述的外筒身采用透明材料。
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