WO2020200160A1 - 一种含喹啉基化合物、药物组合物以及其用途 - Google Patents
一种含喹啉基化合物、药物组合物以及其用途 Download PDFInfo
- Publication number
- WO2020200160A1 WO2020200160A1 PCT/CN2020/082041 CN2020082041W WO2020200160A1 WO 2020200160 A1 WO2020200160 A1 WO 2020200160A1 CN 2020082041 W CN2020082041 W CN 2020082041W WO 2020200160 A1 WO2020200160 A1 WO 2020200160A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- oxy
- fluorophenyl
- cyclopropane
- compound
- Prior art date
Links
- 0 *C(Nc(cc1)ccc1Oc1c(cc(*)c(*S*)c2)c2ncc1)=O Chemical compound *C(Nc(cc1)ccc1Oc1c(cc(*)c(*S*)c2)c2ncc1)=O 0.000 description 2
- NSOPYQNKWIQZMQ-UHFFFAOYSA-N CC(C)(C)C(SCC(NCCCCCOc1cc2nccc(Oc(ccc(NC(C3(CC3)C(Nc(cc3)ccc3F)=O)=O)c3)c3F)c2cc1OC)=O)=O Chemical compound CC(C)(C)C(SCC(NCCCCCOc1cc2nccc(Oc(ccc(NC(C3(CC3)C(Nc(cc3)ccc3F)=O)=O)c3)c3F)c2cc1OC)=O)=O NSOPYQNKWIQZMQ-UHFFFAOYSA-N 0.000 description 1
- ZRUPFVQPOIELQC-UHFFFAOYSA-N CC(C)(C)OC(NCCCCCSC(C)=O)=O Chemical compound CC(C)(C)OC(NCCCCCSC(C)=O)=O ZRUPFVQPOIELQC-UHFFFAOYSA-N 0.000 description 1
- ALTFYKYRYFYAJP-UHFFFAOYSA-N CC(SCC(NCCCCCSc1cc2nccc(Oc(ccc(NC(C3(CC3)C(Nc(cc3)ccc3F)=O)=O)c3)c3F)c2cc1OC)=O)=O Chemical compound CC(SCC(NCCCCCSc1cc2nccc(Oc(ccc(NC(C3(CC3)C(Nc(cc3)ccc3F)=O)=O)c3)c3F)c2cc1OC)=O)=O ALTFYKYRYFYAJP-UHFFFAOYSA-N 0.000 description 1
- BQVKTYMIIQUANE-ONEGZZNKSA-N CC(SCCC/C=C/CCOc1cc2nccc(Oc(c(F)c3)ccc3NC(C3(CC3)C(Nc(cc3)ccc3F)=O)=O)c2cc1OC)=O Chemical compound CC(SCCC/C=C/CCOc1cc2nccc(Oc(c(F)c3)ccc3NC(C3(CC3)C(Nc(cc3)ccc3F)=O)=O)c2cc1OC)=O BQVKTYMIIQUANE-ONEGZZNKSA-N 0.000 description 1
- IKQCAVWASGIZMQ-UHFFFAOYSA-N CC(SCCCCCCCOc1cc2nccc(Oc(cc3)ccc3NC(C3(CC3)C(Nc(cc3)ccc3F)=O)=O)c2cc1OC)=O Chemical compound CC(SCCCCCCCOc1cc2nccc(Oc(cc3)ccc3NC(C3(CC3)C(Nc(cc3)ccc3F)=O)=O)c2cc1OC)=O IKQCAVWASGIZMQ-UHFFFAOYSA-N 0.000 description 1
- WVGCUDQSIQKJKC-UHFFFAOYSA-N CC(SCCNC(NCCOc1cc2nccc(Oc(ccc(NC(C3(CC3)C(Nc(cc3)ccc3F)=O)=O)c3)c3F)c2cc1OC)=O)=O Chemical compound CC(SCCNC(NCCOc1cc2nccc(Oc(ccc(NC(C3(CC3)C(Nc(cc3)ccc3F)=O)=O)c3)c3F)c2cc1OC)=O)=O WVGCUDQSIQKJKC-UHFFFAOYSA-N 0.000 description 1
- SQMOYNSZLVHCLQ-UHFFFAOYSA-N CC1(CC1)C(NC1CC1)=O Chemical compound CC1(CC1)C(NC1CC1)=O SQMOYNSZLVHCLQ-UHFFFAOYSA-N 0.000 description 1
- CGEMWIZIHLOOQS-UHFFFAOYSA-N CC1(CC1)C(Nc(cc1)ccc1[F]C)=O Chemical compound CC1(CC1)C(Nc(cc1)ccc1[F]C)=O CGEMWIZIHLOOQS-UHFFFAOYSA-N 0.000 description 1
- MLCGGRAHHSAJIQ-UHFFFAOYSA-N COc(c(OCCCCCCCSC(c1ccccc1)=O)cc1ncc2)cc1c2Oc(ccc(NC(C1(CC1)C(Nc(cc1)ccc1F)=O)=O)c1)c1F Chemical compound COc(c(OCCCCCCCSC(c1ccccc1)=O)cc1ncc2)cc1c2Oc(ccc(NC(C1(CC1)C(Nc(cc1)ccc1F)=O)=O)c1)c1F MLCGGRAHHSAJIQ-UHFFFAOYSA-N 0.000 description 1
- FGZPJAHMZCGZLP-UHFFFAOYSA-N COc(c(OCCCCCNC(CSC(CN)=O)=O)cc1ncc2)cc1c2Oc(c(F)c1)ccc1NC(C1(CC1)C(Nc(cc1)ccc1F)=O)=O Chemical compound COc(c(OCCCCCNC(CSC(CN)=O)=O)cc1ncc2)cc1c2Oc(c(F)c1)ccc1NC(C1(CC1)C(Nc(cc1)ccc1F)=O)=O FGZPJAHMZCGZLP-UHFFFAOYSA-N 0.000 description 1
- JCZLOXGUKHIUHX-UHFFFAOYSA-N NC(c(c(O)cc1ncc2)cc1c2Oc(ccc(NC(C1(CC1)C(NC1CC1)=O)=O)c1)c1F)=O Chemical compound NC(c(c(O)cc1ncc2)cc1c2Oc(ccc(NC(C1(CC1)C(NC1CC1)=O)=O)c1)c1F)=O JCZLOXGUKHIUHX-UHFFFAOYSA-N 0.000 description 1
- CKZIGXKIPPVMFS-UHFFFAOYSA-N NCC(SCC(NCCCCCOc1cc2nccc(Oc(cc3Cl)ccc3NC(NC3CC3)=O)c2cc1C(N)=O)=O)=O Chemical compound NCC(SCC(NCCCCCOc1cc2nccc(Oc(cc3Cl)ccc3NC(NC3CC3)=O)c2cc1C(N)=O)=O)=O CKZIGXKIPPVMFS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Definitions
- the invention relates to the field of medicine, in particular to a quinolinyl-containing compound, a pharmaceutical composition and its use.
- Vascular endothelial growth factor receptor is a member of the receptor tyrosine kinase family. It produces a series of biochemical and chemical reactions by combining with its ligand vascular endothelial growth factor (VEGF). The physiological process ultimately promotes the formation of new blood vessels. In normal blood vessels, angiogenesis factors and angiogenesis inhibitors maintain a balance. In the process of tumor growth, the high expression of VEGFR and VEGF disrupts this balance and promotes the formation of tumor new blood vessels. Studies have shown that the high expression of receptor specificity and the formation of new blood vessels are prerequisites for tumor growth. The growth and metastasis of malignant tumors must continue to provide adequate nutrition and excrete waste products through surrounding new blood vessels.
- VEGFR-2 is mainly distributed in vascular endothelial cells, if the activity of VEGFR is blocked, the growth and metastasis of tumors can be inhibited directly and indirectly without affecting normal cells, thereby achieving an ideal anti-tumor effect.
- VEGFR inhibitors have been approved by the US FDA for the treatment of tumors.
- Histone deacetylases are also closely related to the occurrence of tumors. Their inhibitors can lower the threshold of tumor cell apoptosis, have a wide range of anti-tumor activities, and can be used in combination with a variety of anti-tumor drugs. Synergy. Human histone deacetylases are divided into four categories: the first category includes HDAC1, HDAC2, HDAC3 and HDAC8; the second category is HDAC4, HDAC5, HDAC7 and HDAC9; HDAC6 and HDAC10 contain two catalytic sites and are classified as type IIa; HDAC11 belongs to Class IV, and its catalytic center contains amino acid residues common to Class I and Class II HDACs.
- An object of the present invention is to provide a novel quinolinyl-containing compound or a pharmaceutically acceptable salt, solvate, active metabolite, polymorph, isotope label, isomer or prodrug thereof, which can be used As tyrosine kinase and/or histone deacetylase inhibitor.
- Another object of the present invention is to provide the use of the above compound or a pharmaceutically acceptable salt, solvate, active metabolite, polymorph, isotope label, isomer or prodrug thereof.
- the present invention provides a quinolinyl-containing compound represented by general formula (I) or (II) or a pharmaceutically acceptable salt, solvate, active metabolite, polymorph, isotope label or isomer,
- Y represents a substituted or unsubstituted C 3 ⁇ 8 cycloalkyl, C 3 ⁇ 8 heterocyclyl, C 6 ⁇ 20 aryl group or C 2 ⁇ 20 hetero aryl group;
- Z represents -O- or -S-;
- R 1 represents a C 1-6 alkoxy group, a C 1-6 alkylthio group or -(CO)NR 7 R 8 ;
- R 2 represents a substituted or unsubstituted hydrogen, C 1 ⁇ 8 alkyl, C 1 ⁇ 8 alkoxy, C 1 ⁇ 8 alkylthio, C 1 ⁇ 8 haloalkyl, C 3 ⁇ 8 cycloalkyl, C 3 1-8 heterocyclyl, C 6 ⁇ 20 aryl group, C 2 ⁇ 20 heteroaryl, - (CO) R 9, - (CS) R 9, or R 2 and optionally one L group -CH 2 - connecting the R 2 and S, -CH 2 - C 3 ⁇ 8 together form a heterocyclyl or heteroaryl C 2 ⁇ 20 aryl group;
- R 3 and R 4 each independently represent substituted or unsubstituted hydrogen, C 1-8 alkyl, C 1-8 alkoxy, C 1-8 alkylthio, C 1-8 haloalkyl, C 3-8 cycloalkyl group, C 3 ⁇ 8 heterocyclyl, C 6 ⁇ 20 aryl group or C 2 ⁇ 20 hetero aryl group;
- R 7 and R 8 each independently represent substituted or unsubstituted hydrogen or C 1-8 alkyl;
- R 9 represents substituted or unsubstituted C 1-8 alkyl, C 1-8 alkoxy, C 1-8 alkylthio group, C 1 ⁇ 8 haloalkyl, C 1 ⁇ 6 alkylsulfonyl, C 1 ⁇ 6 alkylamino group, C 3 ⁇ 8 cycloalkyl, C 3 ⁇ 8 heterocyclyl, C 6 ⁇ 20 aryl group , C 2 ⁇ 20 hetero aryl group, C 1 ⁇ 6 alkylene C 3 ⁇ 8 cycloalkyl, C 1 ⁇ 6 alkylene C 3 ⁇ 8 heterocyclyl, C 1 ⁇ 6 alkylene group C 6 ⁇ 20 aryl group, C 1 ⁇ 6 alkylene C 2 ⁇ 20 hetero aryl group, a hydroxyl, mercapto, nitro, amino, cyano, or R 9 and L group optionally one -
- Hydrogen can be expressed as -H, and can also be replaced with deuterium and tritium equivalents.
- Halogen may include fluorine, chlorine, bromine, and iodine.
- the C 1-8 alkyl group may include methyl, ethyl, n-propyl, isopropyl, 2-methyl-1-propyl, 2-methyl-2-propyl, 2-methyl-1-butan Group, 3-methyl-1-butyl, 2-methyl-3-butyl, 2,2-dimethyl-1-propyl, 2-methyl-1-pentyl, 3-methyl- 1-pentyl, 4-methyl-1-pentyl, 2-methyl-2-pentyl, 3-methyl-2-pentyl, 4-methyl-2-pentyl, 2,2-di Methyl-1-butyl, 3,3-dimethyl-1-butyl, 2-ethyl-1-butyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl , Isopentyl, neopentyl, tert-amyl, hexyl, heptyl, octyl, etc.
- the C 1-8 alkoxy group may be represented by -OC 1-8 alkyl group, wherein the C 1-8 alkyl group includes the same groups as defined above; for example, the C 1-8 alkoxy group may include methoxy, ethyl Oxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, etc.
- the C 1-8 alkylthio group can be represented as -SC 1-8 alkyl, wherein the C 1-8 alkyl group includes the groups as defined above; for example, the C 1-8 alkylthio group may include methylthio, ethyl Sulfur-based etc.
- a C 1-8 haloalkyl group can be represented as a group in which any number of hydrogen atoms in the C 1-8 alkyl group is substituted by a halogen, wherein the C 1-8 alkyl group and the group including the halogen are as defined above; for example, , C 1-8 haloalkyl may include -CF 3 and the like.
- C 1-6 alkylene groups are divalent functional groups with two substitutable bonds, which can include straight-chain alkylene groups and branched-chain alkylene groups, and straight-chain alkylene groups can be expressed as -(CH 2 ) m -, m represents 1 to 6, and may include, for example, methylene, ethylene and the like.
- C 3 ⁇ 8 cycloalkyl may represent a saturated non-aromatic carbocyclic ring, comprising a single carbon ring (having a ring) carbocyclic ring, and bis (having two rings), e.g., C 3 ⁇ 8 cycloalkyl group may comprise Wait.
- C 3 ⁇ 8 heterocyclyl group may be expressed as the C 3 ⁇ 8 cycloalkyl group, any number of ring atoms is substituted with O, S, N, P, Si , etc.
- the resulting hetero atom group, wherein the C 3 ⁇ The groups included in the 8- cycloalkyl group are as defined above.
- C 3 ⁇ 8 heterocyclic groups may include ethylene oxide group, ethylene sulfide group, a ring nitrogen oxide group, azetidinyl group, a dioxetane group, Thietane, tetrahydrofuranyl, pyrrolidinyl, evil Azolidinyl, tetrahydropyrazolyl, pyrrolinyl, dihydrofuranyl, dihydrothienyl, piperidinyl, tetrahydropyranyl, tetrahydrothiopyranyl, morpholinyl, piperazinyl, dihydro Pyridyl, tetrahydropyridyl, dihydropyranyl, tetrahydropyranyl, dihydrothiopyranyl, azepanyl, oxepanyl, thiepanyl, oxazepine Heterobicyclo[2.2.1]heptyl, azaspiro[2.
- C 6 ⁇ 20 aryl group may include monocyclic aryl, bicyclic aryl group or an aryl group more rings, e.g., may include phenyl, biphenyl, naphthyl, phenanthryl, anthracenyl group, an azulenyl group and the like.
- C 2-20 heteroaryl group may contain represent O, S, N, P, Si and other hetero atoms as ring atoms, any number of the resulting unsaturated group, the number of carbon atoms in the heteroaryl group may be 2 to 20 For example, there may be 2, 3, 4, 5, 6, 7, 8, 9, 10, or 10 or more.
- heteroaryl groups may include pyrrolyl, furyl, thienyl, imidazolyl, oxazolyl, pyrazolyl, pyridyl, pyrimidinyl, pyrazinyl, quinolinyl, isoquinolinyl, tetrazolyl, Triazolyl, triazinyl, benzofuranyl, benzothienyl, indolyl, isoindolyl, etc.
- the hydroxyl group can be expressed as -OH.
- the mercapto group can be represented as -SH.
- the nitro group can be expressed as -NO 2 .
- the cyano group can be represented as -CN.
- the carboxyl group can be represented as -COOH, and the H of the carboxyl group can also be substituted by a substituent to form the corresponding ester group, which can be represented as -COOR a .
- the definition of Ra can be the definition of all substituents described in the general formula (I), For example, an ester group substituted with a C 1-8 alkyl group can be represented as a -COOC 1-8 alkyl group, where the C 1-8 alkyl group includes the groups as defined above.
- the sulfonyl group can be represented as -S(O) 2 R a
- the definition of Ra can be the definition of all the substituents described in the general formula (I), for example, a sulfonyl group substituted with a C 1-8 alkyl group can be represented as -S(O) 2 C 1-8 alkyl group, wherein the C 1-8 alkyl group includes groups as defined above.
- the sulfonyl group is a C 1-6 alkylsulfonyl group
- the C 1-6 alkyl group may include all the groups with carbon atoms of 1-6 in the aforementioned definition of "C 1-8 alkyl group”.
- the acyl group can be represented as -COR a , and the definition of Ra can be the definition of all the substituents described in the general formula (I).
- an acyl group substituted with a C 1-8 alkyl group can be represented as -COC 1-8 alkyl.
- the C 1-8 alkyl group includes groups as defined above.
- the acyl group is a C 1-6 alkyl acyl group, and the C 1-6 alkyl group may include all groups with a carbon number of 1-6 in the aforementioned definition of "C 1-8 alkyl".
- the amino group can be represented by -NH 2 , -NHR a or -N(R a ) 2 , and the definition of Ra can be the definition of all substituents described in the general formula (I), for example, C 1-8 alkyl substituted
- the amino group can be represented as -NHC 1-8 alkyl or -N(C 1-8 alkyl) 2 , where the C 1-8 alkyl includes the same groups as defined above.
- the amino group is a C 1-6 alkylamino group
- the C 1-6 alkyl group may include all groups with a carbon number of 1-6 in the aforementioned definition of "C 1-8 alkyl”.
- the amide group can be represented as a -CO amino group, where the amino group is as defined above.
- C 1-6 alkyl may include methyl, ethyl, n-propyl Alkyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, neopentyl, n-hexyl, etc.
- C 1-8 alkyl meets the carbon All groups with the number of atoms 1-6.
- C 1 ⁇ 4 alkyl may include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, t-butyl, the "C 1 ⁇ 8 alkoxy
- radical corresponds to all groups with 1-4 carbon atoms.
- each group such as C, H, O, N, S, etc.
- hydrogen can be replaced with deuterium, tritium, etc., for example, C 1 ⁇ 8 alkane
- the group can be replaced with C 1-8 deuterated alkyl, including but not limited to deuterated methyl, deuterated ethyl, deuterated n-propyl, deuterated isopropyl, deuterated n-butyl, deuterated isobutyl, Deuterated sec-butyl, deuterated tert-butyl, etc.
- the optional substituents on each group include but are not limited to: hydrogen, deuterium, fluorine, chlorine, bromine, methyl, ethyl, propyl, isopropyl, n-butyl Group, sec-butyl, tert-butyl, methoxy, ethoxy, propoxy, isopropoxy, -CN, -CF 3 , -CH 2 CF 3 , -NH 2 , -NH(C 1 ⁇ 4 alkyl), -N (C 1 ⁇ 4 alkyl) 2 , -CO 2 C 1 ⁇ 4 alkyl, -CO 2 H, -NHC(O)C 1 ⁇ 4 alkyl, -SO 2 C 1 ⁇ 4 alkyl, -C(O)NH 2 , -C(O)NH(C 1-4 alkyl), -C(O)N(C 1-4 alkyl) 2 , cyclopropyl, cyclobutyl , Cyclo
- the general formula (I) or (II) is as shown in formula (I-1), (I-2), (II-1) or formula (II-2):
- X represents hydrogen, F or Cl.
- said A represents one of the following groups:
- said L represents one of the following groups:
- said L represents one of the following groups:
- the R 1 represents a C 1-4 alkoxy (for example, methoxy or ethoxy) or -(CO)NH 2 .
- R 2 and L group optionally one -CH 2 - connecting the S and R 2, -CH 2 - C 3 ⁇ 8 together form a heterocyclic group or C 2
- the heterocyclic group or heteroaryl group may also contain other heteroatoms besides S, such as O, N, S, etc.; preferably, the structure formed together contains 4 to 8 rings Heterocyclic group or heteroaryl group of atoms.
- said R 2 represents substituted or unsubstituted hydrogen, C 1-4 alkyl or -(CO)R 9 ;
- R 9 represents substituted or unsubstituted C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, C 3-6 cycloalkyl, C 3-6 heterocyclic group, C 6 ⁇ 12 aryl, C 3 ⁇ 12 heteroaryl, C 1-4 alkylene, C 3-6 cycloalkyl, C 1-4 alkylene, C 3-6 heterocyclyl, C 1-4 alkylene C 6 ⁇ 12 aryl group, C 1 ⁇ 4 alkylene C 3 ⁇ 12 heteroaryl, hydroxy, mercapto, nitro, amino or cyano; optional substituents are selected from F, Cl, Br, methyl, Ethyl, n-propyl, isopropyl, -NH 2 , hydroxyl, carboxy, mercapto or cyano;
- R 9 represents substituted or unsubstituted methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, methoxy, ethoxy, methyl Sulfuryl, methylthio, -(CH 2 ) m -C 3 ⁇ 6 heterocyclic group, -(CH 2 ) m -C 3 ⁇ 12 heteroaryl, phenyl, naphthyl or biphenyl, m represents 1 An integer of ⁇ 3; more preferably, the ring atoms of the heterocyclic group and the heteroaryl group contain at least one N atom.
- a heterocyclic group or heteroaryl group may further contain hetero atoms other than S, for example O, N, S and the like; preferably, the The structure formed together is a heterocyclic group or heteroaryl group containing 4 to 8 ring atoms.
- the compound is selected from the following structures:
- the present invention also provides the above-mentioned compounds or their pharmaceutically acceptable salts, solvates, active metabolites, polymorphs, isotope markers, isomers or prodrugs, and the above-mentioned pharmaceutical compositions for preparing protein kinases and / Or use in medicine for diseases related to histone deacetylase.
- Step B 4-(4-Amino-2-fluorophenoxy)-6-methoxyquinolin-7-ol
- Step B 7-(Benzyloxy)-4-(2-fluoro-4-(1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carboxamido)phenoxy)quinoline -6-carboxylic acid
- Step D N-(4-((6-carbamoyl-7-hydroxyquinolin-4-yl)oxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1 ,1-Diformamide
- Step B N-(4-((7-(3-bromopropoxy)-6-methoxyquinolin-4-yl)oxy)-3-fluorophenyl)-N-(4-fluoro (Phenyl) cyclopropane-1,1-dimethylamide
- Step D S-(3-((4-(2-Fluoro-4-(1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carboxamide)phenoxy)-6-methan (Oxyquinolin-7-yl)oxy)propyl)-(S)-2-amino-3-methylthiobutyrate hydrochloride
- Step A S-(4-bromobutyl)-acetylthio ester
- Step B S-(4-((4-(2-Fluoro-4-(1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carboxamide)phenoxy)-6-methan (Oxyquinolin-7-yl)oxy)butyl)-acetylthioester
- the target compound (28 mg, 26%) was prepared according to the procedure described in Example 7.
- Step C (E)-S-(6-((4-(2-Fluoro-4-(1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carbamoyl)phenoxy )-6-Methoxyquinolin-7-yl)oxy)hexyl-3-en-1-yl)acetylthioester
- the target compound (150 mg, 36%) was prepared from Example 20.
- Step B N-(4-((7-(1-butenyloxy)-6-methoxyquinolin-4-yl)oxy)-3-fluorophenyl)-N-(4-fluoro (Phenyl) cyclopropane-1,1-dimethylamide
- Step C (E)-S-(7-((4-(2-Fluoro-4-(1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carbamoyl)phenoxy )-6-Methoxyquinolin-7-yl)oxy)heptyl-4-en-1-yl)acetylthio ester
- Step A 1-hexene acetyl thioester
- Step B (E)-S-(7-bromoheptyl-5-en-1-yl) acetylthio ester
- Step C (E)-S-(7-((4-(2-Fluoro-4-(1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carbamoyl)phenoxy )-6-Methoxyquinolin-7-yl)oxy)heptyl-5-en-1-yl)acetylthio ester
- the target compound (88 mg, 85%) was prepared according to the procedure described in Example 30.
- the target compound (62 mg, 59%) was prepared according to the procedure described in Example 30.
- Step A S-(7-((4-(2-fluoro-4-(1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carboxamide)phenoxy)-6-methan (Oxyquinolin-7-yl)oxy)heptyl)(S)-2-((tert-butoxycarbonyl)amino)-3-methylthiobutyrate
- Boc-L-valine (85mg, 0.376mmol) was dissolved in DCM (15ml), and 4-dimethylaminopyridine (20mg, 0.376mmol), 1-(3-dimethylaminopropyl)- 3-Ethylcarbodiimide hydrochloride (123mg, 0.628mmol) and keep the reaction at low temperature for 10min, then add N-(3-fluoro-4-((7-(7-mercaptoheptyloxy) to the reaction system -6-Methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dimethylamide (100mg, 0.157mmol, from Example 13 ), and keep at room temperature overnight. After the reaction was completed, the system was washed twice with saturated NaHCO 3 aqueous solution and once with saturated NaCl aqueous solution. The organic phase was dried, concentrated, and purified by column to obtain the target compound (
- Step B S-(7-((4-(2-fluoro-4-(1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carboxamide)phenoxy)-6-methan (Oxyquinolin-7-yl)oxy)heptyl)-(S)-2-amino-3-methylthiobutyrate hydrochloride
- the target compound (51 mg, 59%) was prepared according to the procedure described in Example 33.
- Step A S-(6-Bromoheptyl)-acetylthioester
- Step B S-(7-((4-(4-(1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carboxamide)phenoxy)-6-methoxyquinoline -7-yl)oxy)heptyl)thioacetate
- the target compound (88 mg, 69%) was prepared according to the procedure described in Example 37.
- Step A N-(4-((7-(3,3-Dimethoxypropoxy)-6-methoxyquinolin-4-yl)oxy)-3-fluorophenyl)-N -(4-Fluorophenyl)cyclopropane-1,1-dimethylamide
- Step B N-(3-Fluoro-4-((6-methoxy-7-(3-aldehydepropoxy)quinolin-4-yl)oxy)phenyl)-N-(4- (Fluorophenyl) cyclopropane-1,1-dimethylamide
- Step C N-(3-Fluoro-4-((6-Methoxy-7-(3-((2-Homocysteine lactone-3-yl)amino)propoxy)quinoline -4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dimethylamide
- Example 43 Following the hydrolysis procedure described in Example 42, the target compound (5 mg, 71%) was prepared from Example 43.
- the target compound (5 mg, 71%) was prepared from Example 38.
- Example 13 According to the amino acid condensation and de-Boc steps described in Example 33, the target compound (18 mg, 71%) was prepared from Example 13.
- Example 13 According to the amino acid condensation and de-Boc steps described in Example 33, the target compound (18 mg, 71%) was prepared from Example 13.
- the target compound (57 mg, 54%) was prepared in Example 50.
- the target compound (7 mg, 48%) was prepared.
- Step A N-(4-((7-(2-(3-(2-chloroethyl)ureido)ethoxy)-6-methoxyquinolin-4-yl)oxy)-3 -Fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dimethylamide
- Example 57 Following the hydrolysis procedure described in Example 45, the target compound (12 mg, 67%) was prepared from Example 57.
- the target compound 35 mg, 39%) was prepared from Example 59.
- the target compound (49 mg, 56%) was prepared according to the procedure described in Example 57.
- the target compound (60 mg, 71%) was prepared from Example 61.
- the target compound 120 mg, 64%) was prepared according to the procedure described in Example 57.
- the target compound (52 mg, 72%) was prepared from Example 63.
- the target compound (92 mg, 52%) was prepared according to the procedure described in Example 57.
- Example 65 Following the hydrolysis procedure described in Example 45, the target compound (32 mg, 46%) was prepared from Example 65.
- the target compound (150 mg, 79%) was prepared according to the procedure described in Example 57.
- Example 67 Following the hydrolysis procedure described in Example 45, the target compound (22 mg, 38%) was prepared from Example 67.
- Step B S-(2-((5-bromopentyl)amino)-2-oxoethyl)thioglycolate
- the target compound (100 mg, 21%) was prepared according to the procedure described in Example 69.
- Example 45 According to the hydrolysis procedure described in Example 45, the target compound (18 mg, 43%) was prepared from Example 71.
- the target compound (100 mg, 29%) was prepared according to the procedure described in Example 69.
- Example 73 Following the hydrolysis procedure described in Example 45, the target compound (14 mg, 28%) was prepared from Example 73.
- Step D 4-(2-Fluoro-4-(1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carboxamido)phenoxy)-6-methoxyquinoline-7 -Trifluoromethanesulfonate
- Step E tert-butyl (5-((4-(2-fluoro-4-(1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carboxamido)phenoxy)-6 -Methoxyquinolin-7-yl)mercapto)pentyl)carbamate
- Step F S-(2-((5-((4-(2-fluoro-4-(1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carboxamide)phenoxy) -6-Methoxyquinolin-7-yl)mercapto)pentyl)amino)-2-oxoethyl)thioglycolate
- the target compound (35 mg, 24%) was prepared referring to steps B and C described in Example 57.
- the target compound (40 mg, 30%) was prepared from Example 75.
- the target compound (22 mg, 38%) was prepared from Example 78.
- Example 80 S-(2-((5-((4-(2-Fluoro-4-(1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carboxamido)phenoxy )-6- (Methoxyquinolin-7-yl)oxy)pentyl)amino)-2-oxoethyl)2-aminothioacetate hydrochloride
- the target compound (42 mg, 62%) was prepared using Example 58.
- the target compound (58 mg, 58%) was prepared using Example 58.
- Example 58 was used to prepare the target compound (80 mg, 69%).
- Example 70 According to the amino acid condensation and de-Boc steps described in Example 33, the target compound (59 mg, 67%) was prepared using Example 70.
- the target compound (49 mg, 36%) was prepared using Example 70.
- Example 70 was used to prepare the target compound (63 mg, 51%).
- the target compound (45 mg, 40%) was prepared from Example 86.
- the target compound ((80 mg, 69%)) was prepared using Example 58.
- the target compound 64 mg, 73%) was prepared using Example 58.
- Step A N-acetyl-1-methyl-D-tryptophan
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
实施例 | IC50(nM) | 实施例 | IC50(nM) |
10 | 65.97 | 57 | 48.34 |
11 | 39.35 | 58 | 15.36 |
12 | 67.84 | 61 | 29.92 |
13 | 18 | 62 | 16.31 |
25 | 34.82 | 63 | 97.80 |
28 | 96.46 | 64 | 28.77 |
29 | 42.43 | 69 | 8.94 |
Cabozantinib | >10000 | 71 | 27 |
实施例 | IC50(nM) | 实施例 | IC50(nM) |
6 | 79 | 58 | 25 |
7 | 57 | 61 | 12 |
25 | 79 | 62 | 17 |
27 | 33 | 63 | 36 |
50 | 6.6 | 64 | 51 |
51 | 7.7 | 65 | 13 |
52 | 3.2 | 67 | 30 |
53 | 4.7 | 69 | 0.96 |
54 | 54 | 71 | 4.6 |
55 | 30 | 73 | 45 |
57 | 20 | 86 | 2.6 |
Claims (18)
- 一种如通式(Ⅰ)或(II)所示的含喹啉基的化合物或其药学上可接受的盐、溶剂化物、活性代谢物、多晶型物、同位素标记物或异构体,其中,X表示取代或未取代的氢、卤素或C 1~8烷基;Y表示取代或未取代的C 3~8环烷基、C 3~8杂环基、C 6~20芳基或C 2~20杂芳基;Z表示-O-或-S-;L表示直链-(CH 2) n-,n表示3~10的整数,其中任选的一个或多个-CH 2-可被替换为-NR 5-、-(CO)-、-(CS)-、-CR 5R 6-中的一个或多个,和/或任选的一个或多个-CH 2CH 2-可被替换为-CH=CH-;R 1表示C 1~6烷氧基、C 1~6烷硫基或-(CO)NR 7R 8;R 2表示取代或未取代的氢、C 1~8烷基、C 1~8烷氧基、C 1~8烷硫基、C 1~8卤代烷基、C 3~8环烷基、C 3~8杂环基、C 6~20芳基、C 2~20杂芳基、-(CO)R 9、-(CS)R 9,或R 2与L基团中任选的一个-CH 2-连接,使R 2与S、-CH 2-共同形成C 3~8杂环基或C 2~20杂芳基;R 3、R 4各自独立地表示取代或未取代的氢、C 1~8烷基、C 1~8烷氧基、C 1~8烷硫基、C 1~8卤代烷基、C 3~8环烷基、C 3~8杂环基、C 6~20芳基或C 2~20杂芳基;R 5、R 6各自独立地表示取代或未取代的氢、C 1~8烷基、C 1~8烷氧基、C 1~8烷硫基、C 1~8卤代烷基、羟基、巯基、羧基、氨基或氰基;R 7、R 8各自独立地表示取代或未取代的氢或C 1~8烷基;R 9表示取代或未取代的C 1~8烷基、C 1~8烷氧基、C 1~8烷硫基、C 1~8卤代烷基、C 1~6烷基磺酰基、C 1~6烷基氨基、C 3~8环烷基、C 3~8杂环基、C 6~20芳基、C 2~20杂芳基、C 1~6亚烷基C 3~8环烷基、C 1~6亚烷基C 3~8杂环基、C 1~6亚烷基C 6~20芳基、C 1~6亚烷基C 2~20杂芳基、羟基、巯基、硝基、氨基、氰基,或R 9与L基团中任选的一个-CH 2-连接,使-(CO)R 9或-(CS)R 9与S、-CH 2-共同形成C 3~8杂环基或C 2~20杂芳基;上述基团可选的取代基可选自卤素、C 1~8烷基、C 2~8烯基、C 2~8炔基、C 1~8卤代烷基、C 1~8烷氧基、C 1~8烷硫基、C 3~8环烷基、C 3~8杂环基、C 6~20芳基、C 2~20杂芳基、C 1~6烷基酯基、C 1~6烷基酰基、C 1~6烷基氨基、C 1~6烷基磺酰基、氨基、羟基、巯基、羧基、硝基、酰胺基、或氰基。
- 根据权利要求1-3任一项所述的化合物或其药学上可接受的盐、溶剂化物、活性代谢物、多晶型物、同位素标记物或异构体,其中,L表示以下基团中的一种:-CH 2-CO-NH-(CH 2) p-*,p表示3~6的整数,其中任选的一个或多个-CH 2CH 2-可被替换为-CH=CH-,其中的*端表示连接Z基团的一端;或直链-(CH 2) o-,o表示5~7的整数,其中任选的一个或多个-CH 2CH 2-可被替换为-CH=CH-。
- 根据权利要求1-4任一项所述的化合物或其药学上可接受的盐、溶剂化物、活性代谢物、多晶型物、同位素标记物或异构体,其中,L表示以下基团中的一种:*-CH 2CH=CH(CH 2) q-、*-(CH 2) 2CH=CH(CH 2) q-或*-(CH 2) 3CH=CH(CH 2) q-,q表示1~4的整数,其中的*端表示连接Z基团的一端。
- 根据权利要求1-5任一项所述的化合物或其药学上可接受的盐、溶剂化物、活性代谢物、多晶型物、同位素标记物或异构体,其中,R 1表示C 1~4烷氧基或-(CO)NH 2。
- 根据权利要求1-6任一项所述的化合物或其药学上可接受的盐、溶剂化物、活性代谢物、多晶型物、同位素标记物或异构体,其中,所述R 2表示取代或未取代的氢、C 1~4烷基、或-(CO)R 9;其中的R 9表示取代或未取代的C 1~4烷基、C 1~4烷氧基、C 1~4卤代烷基、C 3~6环烷基、C 3~6杂环基、C 6~12芳基、C 3~12杂芳基、C 1~4亚烷基C 3~6环烷基、C 1~4亚烷基C 3~6杂环基、C 1~4亚烷基C 6~12芳基、C 1~4亚烷基C 3~12杂芳基、羟基、巯基、硝基、氨基或氰基;可选的取代基选自F、Cl、Br、甲基、乙基、正丙基、异丙基、-NH 2、羟基、羧基、巯基或氰基;优选地,R 9表示取代或未取代的甲基、乙基、正丙基、异丙基、正丁基、异丁基、仲丁基、叔丁基、甲氧基、乙氧基、甲硫基、甲硫基、-(CH 2) m-C 3~6杂环基、-(CH 2) m-C 3~12杂芳基、苯基、萘基或联苯基,m表示1~3的整数;更优选地,杂环基和杂芳基的环原子中含有至少一个N原子。
- 一种药物组合物,其包含权利要求1-8任一项所述的化合物或其药学上可接受的盐、溶剂化物、活性代谢物、多晶型物、同位素标记物或异构体,以及药学可接受的载体。
- 权利要求1-8任一项所述的化合物或其药学上可接受的盐、溶剂化物、活性代谢物、多晶型物、同位素标记物或异构体,以及权利要求9所述的药物组合物在制备酪氨酸激酶和/或组蛋白去乙酰化酶相关疾病的药物中的用途。
- 根据权利要求10所述的用途,其中,所述疾病包括银屑病、肝硬化、糖尿病、神经退行性疾病、肿瘤、免疫性疾病及心血管疾病。
- 权利要求1-8任一项所述的化合物或其药学上可接受的盐、溶剂化物、活性代谢物、多晶型物、同位素标记物或异构体,以及权利要求9所述的药物组合物在制备酪氨酸激酶抑制剂和/或组蛋白去乙酰化酶抑制剂中的用途。
- 根据权利要求10-12任一项所述的用途,其中所述酪氨酸激酶包括VEGFR-2。
- 根据权利要求10-12任一项所述的用途,其中所述组蛋白去乙酰化酶包括HDACl、HDAC2、HDAC3、HDAC4、HDAC5、HDAC6、HDAC7、HDAC8、HDAC9、HDAC10及HDAC11。
- 根据权利要求14所述的用途,其中所述组蛋白去乙酰化酶包括HDAC6。
- 一种治疗酪氨酸激酶和/或组蛋白去乙酰化酶相关疾病的方法,所述方法包括向有需要此治疗的受试者给药有效量的权利要求1-8中任一项所述的化合物或其药学上可接受的盐、溶剂化物、活性代谢物、多晶型物、同位素标记物或异构体,或者权利要求9所述的药物组合物。
- 根据权利要求16所述的方法,其中,所述疾病包括银屑病、肝硬化、糖尿病、神经退行性疾病、肿瘤、免疫性疾病及心血管疾病。
- 一种抑制酪氨酸激酶和/或组蛋白去乙酰化酶的方法,所述方法包括将酪氨酸激酶和/或组蛋白去乙酰化酶与有效量的权利要求1-8中任一项所述的化合物或其药学上可接受的盐、溶剂化物、活性代谢物、多晶型物、同位素标记物或异构体,或者权利要求9所述的药物组合物接触。
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2021558869A JP7423655B2 (ja) | 2019-04-03 | 2020-03-30 | キノリル含有化合物、医薬組成物およびその使用 |
CN202080026629.7A CN113924288B (zh) | 2019-04-03 | 2020-03-30 | 一种含喹啉基化合物、药物组合物以及其用途 |
EP20783185.0A EP3950677A4 (en) | 2019-04-03 | 2020-03-30 | QUINOLYL CONTAINING COMPOUND AND PHARMACEUTICAL COMPOSITION AND THEIR USE |
MX2021012124A MX2021012124A (es) | 2019-04-03 | 2020-03-30 | Compuestos que contienen quinolilo y composicion farmaceutica, y uso de los mismos. |
CA3135921A CA3135921C (en) | 2019-04-03 | 2020-03-30 | Quinolyl-containing compound and pharmaceutical composition, and use thereof |
US17/594,039 US20220162184A1 (en) | 2019-04-03 | 2020-03-30 | Quinolyl-containing compound and pharmaceutical composition, and use thereof |
BR112021019491A BR112021019491A2 (pt) | 2019-04-03 | 2020-03-30 | Composto contendo quinolila e composição farmacêutica, e uso dos mesmos |
AU2020255702A AU2020255702B2 (en) | 2019-04-03 | 2020-03-30 | Quinolyl-containing compound and pharmaceutical composition, and use thereof |
KR1020217035919A KR102690225B1 (ko) | 2019-04-03 | 2020-03-30 | 퀴놀린 함유 화합물, 의약 조성물 및 그의 용도 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910266681 | 2019-04-03 | ||
CN201910266681.9 | 2019-04-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2020200160A1 true WO2020200160A1 (zh) | 2020-10-08 |
Family
ID=72664700
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2020/082041 WO2020200160A1 (zh) | 2019-04-03 | 2020-03-30 | 一种含喹啉基化合物、药物组合物以及其用途 |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220162184A1 (zh) |
EP (1) | EP3950677A4 (zh) |
JP (1) | JP7423655B2 (zh) |
KR (1) | KR102690225B1 (zh) |
CN (1) | CN113924288B (zh) |
AU (1) | AU2020255702B2 (zh) |
BR (1) | BR112021019491A2 (zh) |
CA (1) | CA3135921C (zh) |
MX (1) | MX2021012124A (zh) |
WO (1) | WO2020200160A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114573553A (zh) * | 2022-01-27 | 2022-06-03 | 广州六顺生物科技股份有限公司 | 杂芳环类衍生物及其制备方法和应用 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11535607B2 (en) | 2018-04-20 | 2022-12-27 | Valo Health, Inc. | Isoindolines as HDAC inhibitors |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070027184A1 (en) * | 2005-07-29 | 2007-02-01 | Kalypsys, Inc. | Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease |
CN102408411A (zh) * | 2011-09-19 | 2012-04-11 | 广州盈升生物科技有限公司 | 一种含喹啉基的羟肟酸类化合物及其制备方法、以及含有该化合物的药物组合物及其应用 |
CN105131082A (zh) * | 2015-09-17 | 2015-12-09 | 广州康缔安生物科技有限公司 | 环肽类化合物及其应用 |
WO2018072614A1 (zh) * | 2016-10-18 | 2018-04-26 | 北京康辰药业股份有限公司 | 一种喹啉基取代的羧酸化合物或其药学上可接受的盐、其药物组合物及应用 |
WO2018226542A1 (en) * | 2017-06-09 | 2018-12-13 | Arvinas, Inc. | Modulators of proteolysis and associated methods of use |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0860433B1 (en) * | 1995-11-07 | 2002-07-03 | Kirin Beer Kabushiki Kaisha | Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of growth factor receptor originating in platelet and pharmaceutical compositions containing the same |
NZ525324A (en) * | 2000-10-20 | 2005-03-24 | Eisai Co Ltd | Nitrogenous aromatic ring compounds |
-
2020
- 2020-03-30 AU AU2020255702A patent/AU2020255702B2/en active Active
- 2020-03-30 BR BR112021019491A patent/BR112021019491A2/pt unknown
- 2020-03-30 US US17/594,039 patent/US20220162184A1/en active Pending
- 2020-03-30 EP EP20783185.0A patent/EP3950677A4/en active Pending
- 2020-03-30 JP JP2021558869A patent/JP7423655B2/ja active Active
- 2020-03-30 CA CA3135921A patent/CA3135921C/en active Active
- 2020-03-30 CN CN202080026629.7A patent/CN113924288B/zh active Active
- 2020-03-30 WO PCT/CN2020/082041 patent/WO2020200160A1/zh unknown
- 2020-03-30 KR KR1020217035919A patent/KR102690225B1/ko active IP Right Grant
- 2020-03-30 MX MX2021012124A patent/MX2021012124A/es unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070027184A1 (en) * | 2005-07-29 | 2007-02-01 | Kalypsys, Inc. | Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease |
CN102408411A (zh) * | 2011-09-19 | 2012-04-11 | 广州盈升生物科技有限公司 | 一种含喹啉基的羟肟酸类化合物及其制备方法、以及含有该化合物的药物组合物及其应用 |
CN105131082A (zh) * | 2015-09-17 | 2015-12-09 | 广州康缔安生物科技有限公司 | 环肽类化合物及其应用 |
WO2018072614A1 (zh) * | 2016-10-18 | 2018-04-26 | 北京康辰药业股份有限公司 | 一种喹啉基取代的羧酸化合物或其药学上可接受的盐、其药物组合物及应用 |
WO2018226542A1 (en) * | 2017-06-09 | 2018-12-13 | Arvinas, Inc. | Modulators of proteolysis and associated methods of use |
Non-Patent Citations (7)
Title |
---|
AL BINGHAM ET AL., CHEM. COMMUN., 2001, pages 603 - 604 |
CAREYSUNDBERG'S: "Advanced Organic Chemistry", vol. A, 2000, PLENUM PRESS |
E.C. VAN TONDER ET AL., AAPS PHARMSCITECH., vol. 5, no. 1, 2004 |
GREENEWUTS: "Protective Groups In Organic Synthesis", 1991, WILEY AND SONS |
HEIDER, U. ET AL.: "Histone deacetylase inhibitors reduce VEGF production and induce growth suppression and apoptosis in human mantle cell lymphoma", EUR J HAEMATOL, vol. 76, no. 1,, 27 October 2005 (2005-10-27), XP055212734 * |
M. CAIRA ET AL., J. PHARMACEUTICAL SCI., vol. 93, no. 3, 2004, pages 601 - 611 |
See also references of EP3950677A4 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114573553A (zh) * | 2022-01-27 | 2022-06-03 | 广州六顺生物科技股份有限公司 | 杂芳环类衍生物及其制备方法和应用 |
CN114573553B (zh) * | 2022-01-27 | 2023-11-10 | 广州六顺生物科技有限公司 | 杂芳环类衍生物及其制备方法和应用 |
Also Published As
Publication number | Publication date |
---|---|
MX2021012124A (es) | 2021-12-10 |
AU2020255702A1 (en) | 2021-11-25 |
AU2020255702B2 (en) | 2023-04-13 |
CA3135921A1 (en) | 2020-10-08 |
CN113924288A (zh) | 2022-01-11 |
US20220162184A1 (en) | 2022-05-26 |
CN113924288B (zh) | 2024-04-05 |
BR112021019491A2 (pt) | 2021-11-30 |
JP2022528109A (ja) | 2022-06-08 |
KR20210148296A (ko) | 2021-12-07 |
EP3950677A4 (en) | 2023-01-11 |
CA3135921C (en) | 2024-04-16 |
EP3950677A1 (en) | 2022-02-09 |
JP7423655B2 (ja) | 2024-01-29 |
KR102690225B1 (ko) | 2024-07-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2020177653A1 (zh) | 吡嗪类衍生物及其在抑制shp2中的应用 | |
CN103476768B (zh) | 6,5-杂环炔丙醇化合物及其用途 | |
WO2017101803A1 (zh) | 一种新型egfr和alk激酶的双重抑制剂 | |
EA023350B1 (ru) | Противомикробные соединения, способы их получения и применение | |
WO2019206069A1 (zh) | 一种二芳基巨环化合物、药物组合物以及其用途 | |
TW201625620A (zh) | 作為蛋白去乙醯酶抑制劑及雙蛋白去乙醯酶蛋白激酶抑制劑之雜環氧肟酸及其使用方法 | |
TW201625533A (zh) | Kcnq 2至5通道活化劑 | |
CN111247152A (zh) | 作为激酶抑制剂的环状亚氨基嘧啶衍生物 | |
WO2020200160A1 (zh) | 一种含喹啉基化合物、药物组合物以及其用途 | |
US11548900B2 (en) | Oxazino-quinazoline and oxazino-quinoline type compound, preparation method and uses thereof | |
CN113880772B (zh) | 一类cdk激酶抑制剂及其应用 | |
CN112851557B (zh) | 磺基取代的联芳基类化合物或其盐及其制备方法和用途 | |
CN102149678A (zh) | 用于治疗癌症的新型邻氨基酰苯胺类 | |
WO2022007841A1 (zh) | 一种egfr抑制剂、其制备方法和在药学上的应用 | |
WO2009146871A1 (en) | 5-lipoxygenase inhibitors | |
RU2803116C2 (ru) | Хинолинил-содержащее соединение и его фармацевтическая композиция и применение | |
JP2022527279A (ja) | キノリン誘導体及び癌の治療のためのその使用 | |
WO2024094016A1 (zh) | 一种二噁烷并喹啉类化合物的盐、其晶型以及它们的制备方法及应用 | |
US11905273B2 (en) | Inhibitors for the B-catenin/B-cell lymphoma 9 (BCL9) protein-protein interaction | |
US11472774B2 (en) | Anti-cancer compounds | |
WO2014190872A1 (zh) | 一种含硒化合物及其医药用途 | |
WO2024099403A1 (zh) | 一种具有软药性质的硫醚类化合物、药物组合物及其用途 | |
TW202126661A (zh) | 作為轉運子調節劑之雙環羧酸化物及其用途 | |
WO2020011086A1 (zh) | 苯并二氮杂环类化合物、其制备方法及用途 | |
CN103012274A (zh) | 异羟肟酸类化合物,制备方法和用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 20783185 Country of ref document: EP Kind code of ref document: A1 |
|
ENP | Entry into the national phase |
Ref document number: 2021558869 Country of ref document: JP Kind code of ref document: A Ref document number: 3135921 Country of ref document: CA |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
REG | Reference to national code |
Ref country code: BR Ref legal event code: B01A Ref document number: 112021019491 Country of ref document: BR |
|
ENP | Entry into the national phase |
Ref document number: 20217035919 Country of ref document: KR Kind code of ref document: A |
|
ENP | Entry into the national phase |
Ref document number: 2020255702 Country of ref document: AU Date of ref document: 20200330 Kind code of ref document: A |
|
ENP | Entry into the national phase |
Ref document number: 112021019491 Country of ref document: BR Kind code of ref document: A2 Effective date: 20210929 |
|
ENP | Entry into the national phase |
Ref document number: 2020783185 Country of ref document: EP Effective date: 20211103 |