WO2020192090A1 - 一种防止磁颗粒沉积的试剂盒存储架 - Google Patents

一种防止磁颗粒沉积的试剂盒存储架 Download PDF

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Publication number
WO2020192090A1
WO2020192090A1 PCT/CN2019/111361 CN2019111361W WO2020192090A1 WO 2020192090 A1 WO2020192090 A1 WO 2020192090A1 CN 2019111361 W CN2019111361 W CN 2019111361W WO 2020192090 A1 WO2020192090 A1 WO 2020192090A1
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storage rack
magnetic particles
deposition
preventing
magnet
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PCT/CN2019/111361
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English (en)
French (fr)
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胡统号
苗新利
吴冬
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苏州长光华医生物医学工程有限公司
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Publication of WO2020192090A1 publication Critical patent/WO2020192090A1/zh

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers

Definitions

  • This application belongs to the technical field of medical devices, and in particular relates to a storage rack for a reagent kit that prevents the deposition of magnetic particles.
  • reagent bottles are used to store, transport and use reagents needed for experiments. After the reagents are stored, the reagents in the reagent bottles will be uneven due to long-term standing. If they are directly used in experiments, the experimental results will be incorrect.
  • a commonly used reagent is magnetic particles. Because magnetic beads are nano-scale magnetic materials and are insoluble in water, this reagent is easy to precipitate.
  • the general chemiluminescence immunoassay analyzer uses the method of rotating the reagent bottle for shaking. Since the reagent bottle should minimize the dead volume, the round bottom design is generally adopted to reduce reagent waste. This round-bottom design causes the magnetic beads to concentrate in the center of the bottom of the bottle. In addition, the inner wall of the reagent bottle is smooth, and it is difficult to stir and roll the magnetic particles at the bottom to the upper liquid surface, so the shaking effect of the magnetic particles is poor.
  • the technical problem to be solved by the present invention is: in order to solve the deficiencies in the prior art, thereby providing a storage rack for a reagent kit that prevents the deposition of magnetic particles.
  • a storage rack for a reagent kit to prevent the deposition of magnetic particles including
  • the bottom plate is made of non-magnetic material
  • Two side plates and one back plate are made of non-magnetic material, and a space for accommodating reagent kits enclosed on three sides is formed between the two side plates and one back plate;
  • the magnets are respectively arranged on two opposite sides of the two side plates.
  • the magnet is a permanent magnet, and the magnetic poles of the opposite sides of the two magnets on different side plates are opposite.
  • the permanent magnet is a neodymium iron boron magnet.
  • the center of the magnet is located at the height of 2/5-3/5 of the reagent bottle body.
  • the rear plate is provided with a card slot matched with a tooth at the end of the reagent box.
  • the front ends of the two side plates are inclined surfaces with a gradually decreasing height.
  • a stepped magnet mounting groove is formed at the end of the side plate, and the magnet is placed in the magnet mounting groove and fixed by the magnet cover.
  • the side plate and the back plate are both fixed on the bottom plate by screws.
  • the magnet may also be an electromagnet, and a controller and a timer connected to the electromagnet are also provided on the storage rack, and the timer controls the magnetic field of the electromagnet at regular intervals. The intensity and/or direction of the magnetic field changes.
  • the controller and the timer are placed in the bottom plate, and a battery may be provided in the bottom plate to supply power to the controller, the timer and the electromagnet.
  • the reagent kit storage rack for preventing the deposition of magnetic particles of the present invention includes: a bottom plate made of a non-magnetic material, two side plates and a back plate; magnets are respectively arranged on two opposite sides of the two side plates, A space for accommodating the reagent box enclosed on three sides is formed between the two side plates and one rear plate.
  • the reagent kit storage rack for preventing the deposition of magnetic particles of the present invention magnetically attracts the magnetic particles to the upper end of the reagent bottle through a magnet, thereby preventing the magnetic particles from gathering at the bottom of the reagent bottle, thereby reducing the shaking time of the magnetic particles by more than half.
  • FIG. 1 is a schematic structural diagram of a storage rack for a reagent kit for preventing magnetic particle deposition according to an embodiment of the present application
  • Figure 2 is a schematic diagram of the structure of the magnet mounting groove and the magnet cover
  • Fig. 3 is a schematic diagram of the reagent kit being inserted into the reagent cartridge storage rack
  • Figure 4 is a schematic diagram of the height setting of the magnet
  • Figure 5 is a structural diagram of an electromagnet control circuit.
  • connection should be interpreted broadly unless otherwise clearly specified and limited.
  • it can be a fixed connection or a detachable connection. Connected or integrally connected; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the internal communication between two components.
  • connection should be interpreted broadly unless otherwise clearly specified and limited.
  • it can be a fixed connection or a detachable connection. Connected or integrally connected; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the internal communication between two components.
  • This embodiment provides a reagent kit storage rack for preventing the deposition of magnetic particles, as shown in FIG. 1, including:
  • the bottom plate 1 is made of a non-magnetic material, and the non-magnetic material can be a metal such as aluminum or plastic;
  • Two side plates 2 and one back plate 3 are made of non-magnetic material.
  • the two side plates 2 and one back plate 3 form a three-sided enclosed space for accommodating reagent boxes.
  • the distance between the two side plates 2 and the reagent The width of the box is related, usually 0.4-0.8mm larger than the width of the kit to ensure that the kit can be easily inserted into the slot without large friction, and the magnet 4 can be close to the magnetic bead bottle;
  • the magnets 4 are respectively arranged on the two opposite sides of the two side plates 2.
  • the opposite sides of the two magnets 4 on the different side plates 2 have opposite magnetic poles (that is, the opposite poles of the magnets 4 are opposite, and the opposite poles can strengthen the left and right sides.
  • the magnetic induction between the plates increases the attractive force of the magnet 4 to the magnetic particles).
  • the magnet 4 may be a permanent magnet, such as a neodymium iron boron magnet.
  • the center of the magnet 4 is located at the height of 2/5-3/5 of the reagent bottle body.
  • the storage rack of the reagent kit for preventing the deposition of magnetic particles in this embodiment magnetically attracts the magnetic particles to the upper end of the reagent bottle through the magnet 4, thereby preventing the magnetic particles from accumulating at the bottom of the reagent bottle, thereby reducing the shaking time of the magnetic particles by half the above.
  • the rear plate 3 is provided with a card slot 31 matched with the card teeth 81 at the end of the reagent box, and the card slot 31 can fix the reagent box.
  • the front ends of the two side plates 2 are inclined surfaces with a gradually decreasing height, and the inclined surfaces are arc-shaped to facilitate the taking of the kit.
  • the shape of the side plate 2 may be various, for example, it may be a rectangular plate, a right-angled trapezoidal plate, or a right-angled trapezoidal plate with a parabolic hypotenuse.
  • a stepped magnet mounting groove 41 is formed at the end of the side plate 2, and the magnet 4 is placed in the magnet mounting groove 41 and fixed by the magnet cover 42.
  • the position of the magnet 4 on the side plate 2 is determined according to the position of the reagent bottle 82 where the magnetic beads are placed in the kit 80, and the magnet 4 may correspond to the position of the reagent bottle 82 where the magnetic beads are placed.
  • Both the side plate 2 and the rear plate 3 are fixed on the bottom plate 1 by screws.
  • the magnet 4 can also be an electromagnet.
  • a controller 91 and a timer 92 connected to the electromagnet are provided.
  • the timer 92 regularly controls the magnetic field strength and/or the direction of the magnetic field of the electromagnet to change. Power off, change the size and direction of the current.
  • the electromagnet When the electromagnet is energized, a magnetic field is generated. When the power is off, no magnetic field is generated, or the magnetic field strength is changed. By changing the magnetic field strength, a certain stirring effect can be formed, so that the magnetic beads will generate Lifting (when there is a magnetic field or when the magnetic field is strong) and settling (when there is no magnetic field or when the magnetic field is weak) can prevent the magnetic beads from gathering due to a constant magnetic field.
  • the controller 91 and the timer 92 are circuit boards.
  • the circuit board can be placed in the bottom plate 1.
  • a battery 93 can also be provided in the bottom plate 1 to supply power to the circuit board.
  • the wires connecting the electromagnets are connected through the through holes of the side plate 2.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

一种防止磁颗粒沉积的试剂盒存储架，包括：由非导磁性材料制成的底板(1)、两个侧板(2)和一个后板(3)；分别设置在两个侧板(2)相对的两个侧面上的磁体(4)，两个侧板(2)和一个后板(3)之间形成三面包围的容纳试剂盒的空间。所述防止磁颗粒沉积的试剂盒存储架，通过磁体(4)将磁颗粒磁吸到试剂瓶的上端，从而防止磁颗粒在试剂瓶瓶底聚集，从而可以将磁颗粒的摇匀时间缩短一半以上。

Description

一种防止磁颗粒沉积的试剂盒存储架 技术领域
本申请属于医疗器械技术领域，尤其是涉及一种防止磁颗粒沉积的试剂盒存储架。
背景技术
在医疗器械设备中，试剂瓶用来对实验所需试剂进行储存、运输和使用。试剂经过存储后，由于长时间静置，易导致试剂瓶内的试剂不均匀，如果直接用于实验，会导致实验结果不正确。
在化学发光免疫分析领域，常用到一种试剂为磁颗粒，由于磁珠为纳米级的磁性材料，且不溶水，因此这种试剂极易沉淀。
一般的化学发光免疫分析仪采用转动试剂瓶的方式进行摇匀，由于试剂瓶要尽量减少死体积，所以一般采用圆底设计，以减少试剂浪费。这种圆底设计导致磁珠沉淀集中在瓶底中心，加之试剂瓶内壁光滑，很难将底部的磁颗粒搅动翻滚至上层液面，所以磁颗粒的摇匀效果较差。
如果采用手动摇匀，或者借助摇匀仪器进行辅助摇匀，磁珠液液面会产生很多气泡，气泡的存在影响仪器液面探测的准确性，影响加样准确性。
发明内容
本发明要解决的技术问题是：为解决现有技术中的不足，从而提供一种防止磁颗粒沉积的试剂盒存储架。
本发明解决其技术问题所采用的技术方案是：
一种防止磁颗粒沉积的试剂盒存储架，包括
底板，由非导磁性材料制成；
两个侧板和一个后板，由非导磁性材料制成，两个侧板和一个后板之间形成三面包围的容纳试剂盒的空间；
磁体，分别设置在两个侧板相对的两个侧面上。
优选地，本发明的防止磁颗粒沉积的试剂盒存储架，所述磁体为永磁体，且位 于不同侧板上的两个磁体相对的一面的磁极相反。
优选地，本发明的防止磁颗粒沉积的试剂盒存储架，所述永磁体为钕铁硼磁体。
优选地，本发明的防止磁颗粒沉积的试剂盒存储架，所述磁体中心位于试剂瓶瓶身的2/5-3/5高度处。
优选地，本发明的防止磁颗粒沉积的试剂盒存储架，所述后板上设置有与试剂盒末端的卡齿配合的卡槽。
优选地，本发明的防止磁颗粒沉积的试剂盒存储架，两个侧板的前端为高度逐渐下降的斜面。
优选地，本发明的防止磁颗粒沉积的试剂盒存储架，所述侧板的尾端成型有台阶状的磁体安装槽，磁体放置入磁体安装槽内，并由磁体盖板固定。
优选地，本发明的防止磁颗粒沉积的试剂盒存储架，所述侧板和后板均通过螺钉固定在底板上。
优选地，本发明的防止磁颗粒沉积的试剂盒存储架，磁体还可以为电磁体，所述存储架上还设置与电磁体连接的一控制器和定时器，定时器定时控制电磁体的磁场强度和/或磁场的方向发生变化。
优选地，本发明的防止磁颗粒沉积的试剂盒存储架，所述控制器和定时器放置在底板内，所述底板内还可以设置电池给所述控制器、定时器和电磁体供电。
本发明的有益效果是：
本发明的防止磁颗粒沉积的试剂盒存储架，包括：由非导磁性材料制成的底板、两个侧板和一个后板；分别设置在两个侧板相对的两个侧面上的磁体，两个侧板和一个后板之间形成三面包围的容纳试剂盒的空间。本发明的防止磁颗粒沉积的试剂盒存储架，通过磁体将磁颗粒磁吸到试剂瓶的上端，从而防止磁颗粒在试剂瓶瓶底聚集，从而可以将磁颗粒的摇匀时间缩短一半以上。
附图说明
下面结合附图和实施例对本申请的技术方案进一步说明。
图1是本申请实施例的防止磁颗粒沉积的试剂盒存储架的结构示意图；
图2为磁体安装槽和磁体盖板的结构示意图；
图3是试剂盒卡入试剂盒存储架内的示意图；
图4是磁体高度设置的示意图；
图5是对电磁体控制电路的结构图。
图中的附图标记为：
1底板；
2侧板；
3后板；
31卡槽；
4磁体；
41磁体安装槽；
42磁体盖板；
80试剂盒；
81卡齿；
82试剂瓶；
91控制器；
92定时器；
93电池。
具体实施方式
需要说明的是，在不冲突的情况下，本申请中的实施例及实施例中的特征可以相互组合。
在本申请的描述中，需要理解的是，术语“中心”、“纵向”、“横向”、“上”、“下”、“前”、“后”、“左”、“右”、“竖直”、“水平”、“顶”、“底”、“内”、“外”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本申请和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本申请保护范围的限制。此外，术语“第一”、“第二”等仅用于描述目的，而不能理解为指示或暗示相对重要性或者隐含指明所指示的技术特征的数量。由此，限定有“第一”、“第二”等的特征可以明示或者隐含地包括一个或者更多个该特征。在本发明创造的描述中 ，除非另有说明，“多个”的含义是两个或两个以上。
在本申请的描述中，需要说明的是，除非另有明确的规定和限定，术语“安装”、“相连”、“连接”应做广义理解，例如，可以是固定连接，也可以是可拆卸连接，或一体地连接；可以是机械连接，也可以是电连接；可以是直接相连，也可以通过中间媒介间接相连，可以是两个元件内部的连通。对于本领域的普通技术人员而言，可以通过具体情况理解上述术语在本申请中的具体含义。
下面将参考附图并结合实施例来详细说明本申请的技术方案。实施例
本实施例提供一种防止磁颗粒沉积的试剂盒存储架，如图1所示，包括：
底板1，由非导磁性材料制成，非导磁性材料可以是铝之类的金属，也可以是塑料等；
两个侧板2和一个后板3，由非导磁性材料制成，两个侧板2和一个后板3之间形成三面包围的容纳试剂盒的空间，两个侧板2的距离与试剂盒的宽度有关，通常比试剂盒的宽度大0.4-0.8mm，以保证试剂盒能够轻松插入槽内而不受较大摩擦力，又能使磁体4贴近磁珠瓶；
磁体4，分别设置在两个侧板2相对的两个侧面上，位于不同侧板2上的两个磁体4相对的一面的磁极相反(即磁体4异极相对，异极相对可以增强左右侧板之间的磁感应强度，加大磁体4对磁颗粒的吸引力)，磁体4可以为永磁体，比如钕铁硼磁体。
所述磁体4中心位于试剂瓶瓶身的2/5-3/5高度处。
磁颗粒沉淀后，如果直接把试剂盒防止在试剂仓里使用，磁珠在30mins内都无法摇匀，使用防止磁颗粒沉积的试剂盒存储架后，试剂瓶内的磁珠仅10mins就可以摇匀了。本实施例的防止磁颗粒沉积的试剂盒存储架，通过磁体4将磁颗粒磁吸到试剂瓶的上端，从而防止磁颗粒在试剂瓶瓶底聚集，从而可以将磁颗粒的摇匀时间缩短一半以上。
所述后板3上设置有与试剂盒末端的卡齿81配合的卡槽31，卡槽31可以固定试剂盒。
优选地，两个侧板2的前端为高度逐渐下降的斜面，所述斜面为弧形，以方便试剂盒的拿取。作为替代的实施方式，侧板2的形状可以是多样的，比如可以是 矩形的板或者为直角梯形板或者为斜边为抛物线的直角梯形板等等。
侧板2的尾端成型有台阶状的磁体安装槽41，磁体4放置入磁体安装槽41内，并由磁体盖板42固定。
需要说明的是，磁体4在侧板2上的位置是根据试剂盒80内放置磁珠的试剂瓶82的位置来确定的，磁体4与放置磁珠的试剂瓶82的位置对应即可。
侧板2和后板3均通过螺钉固定在底板1上。
磁体4还可以为电磁体，同时，设置与电磁体连接的一控制器91和定时器92，定时器92定时控制电磁体的磁场强度和/或磁场的方向发生变化，比如可以交替进行通电和断电，改变电流大小、电流方向，电磁体通电时产生磁场，断电时不产生磁场，或者使磁场强度发生改变，通过改变磁场强度可以形成一定的搅拌作用，使磁珠在试剂瓶内发生提升(有磁场或者磁场较强时)和沉降(无磁场或者磁场较弱时)，可以防止因恒定的磁场，导致磁珠聚集。控制器91和定时器92是电路板，电路板可以放置在底板1内，底板1内还可以设置电池93给电路板供电，连接电磁体的电线通过侧板2的通孔进行连接。
以上述依据本申请的理想实施例为启示，通过上述的说明内容，相关工作人员完全可以在不偏离本项申请技术思想的范围内，进行多样的变更以及修改。本项申请的技术性范围并不局限于说明书上的内容，必须要根据权利要求范围来确定其技术性范围。
发明概述
技术问题
问题的解决方案
发明的有益效果

Claims (10)

  1. 一种防止磁颗粒沉积的试剂盒存储架，其特征在于，包括：
    底板(1)，由非导磁性材料制成；
    两个侧板(2)和一个后板(3)，由非导磁性材料制成，两个侧板(2)和一个后板(3)之间形成三面包围的容纳试剂盒的空间；
    磁体(4)，分别设置在两个侧板(2)相对的两个侧面上。
  2. 根据权利要求1所述的防止磁颗粒沉积的试剂盒存储架，其特征在于，所述磁体(4)为永磁体，且位于不同侧板(2)上的两个磁体(4)相对的一面的磁极相反。
  3. 根据权利要求2所述的防止磁颗粒沉积的试剂盒存储架，其特征在于，所述永磁体为钕铁硼磁体。
  4. 根据权利要求1-3任一项所述的防止磁颗粒沉积的试剂盒存储架，其特征在于，所述磁体(4)中心位于试剂瓶瓶身的2/5-3/5高度处。
  5. 根据权利要求1-4任一项所述的防止磁颗粒沉积的试剂盒存储架，其特征在于，所述后板(3)上设置有与试剂盒末端的卡齿配合的卡槽(31)。
  6. 根据权利要求1-5任一项所述的防止磁颗粒沉积的试剂盒存储架，其特征在于，两个侧板(2)的前端为高度逐渐下降的斜面。
  7. 根据权利要求1-6任一项所述的防止磁颗粒沉积的试剂盒存储架，其特征在于，所述侧板(2)的尾端成型有台阶状的磁体安装槽( 41)，磁体(4)放置入磁体安装槽(41)内，并由磁体盖板(42)固定。
  8. 根据权利要求1-7任一项所述的防止磁颗粒沉积的试剂盒存储架，其特征在于，所述侧板(2)和后板(3)均通过螺钉固定在底板(1)上。
  9. 根据权利要求1-8任一项所述的防止磁颗粒沉积的试剂盒存储架，其特征在于，磁体(4)还可以为电磁体，所述存储架上还设置与电磁体连接的一控制器(91)和定时器(92)，定时器(92)定时控制电磁体的磁场强度和/或磁场的方向发生变化。
  10. 根据权利要求9所述的防止磁颗粒沉积的试剂盒存储架，其特征在于，所述控制器(91)和定时器(92)放置在底板(1)内，所述底板(1)内还可以设置电池给所述控制器(91)、定时器(92)和电磁体供电。
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