WO2020171132A1 - 水溶性ナノコロイドシリカの製造方法、及び水溶性ナノコロイドシリカ - Google Patents

水溶性ナノコロイドシリカの製造方法、及び水溶性ナノコロイドシリカ Download PDF

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WO2020171132A1
WO2020171132A1 PCT/JP2020/006600 JP2020006600W WO2020171132A1 WO 2020171132 A1 WO2020171132 A1 WO 2020171132A1 JP 2020006600 W JP2020006600 W JP 2020006600W WO 2020171132 A1 WO2020171132 A1 WO 2020171132A1
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water
soluble
silica
nanocolloidal
nanocolloidal silica
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French (fr)
Japanese (ja)
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義博 唐津
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Minami Nihon Wellness Ltd Co
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Minami Nihon Wellness Ltd Co
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Priority to JP2021502100A priority Critical patent/JP7388750B2/ja
Publication of WO2020171132A1 publication Critical patent/WO2020171132A1/ja
Anticipated expiration legal-status Critical
Priority to JP2023191562A priority patent/JP2024023263A/ja
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B33/00—Silicon; Compounds thereof
    • C01B33/113—Silicon oxides; Hydrates thereof
    • C01B33/12—Silica; Hydrates thereof, e.g. lepidoic silicic acid
    • C01B33/14—Colloidal silica, e.g. dispersions, gels, sols
    • C01B33/141—Preparation of hydrosols or aqueous dispersions

Definitions

  • the present invention relates to a method for producing water-soluble nanocolloidal silica and water-soluble nanocolloidal silica.
  • Silicon Si is an element that is most abundant next to oxygen O on the earth. Silicon exists only in a state of being bonded to other elements such as oxygen and molecules, and exists in a state of, for example, quartz (crystal) in which silicon dioxide SiO 2 is crystallized. Silicic acids such as silicon dioxide are commonly referred to as "silica". Silica is contained in large amounts in the bones, joints, blood vessels, skin, hair, teeth, nails, etc. that make up the human body, and plays a role in suppressing aging by connecting tissues to maintain flexibility and elasticity. ing. In addition, silica plays a role of preventing cholesterol from depositing in blood vessels and a role of holding collagen and hyaluronic acid, which are essential moisturizing ingredients for beauty, together. As described above, since silica is a trace component essential for maintaining good health, a lack of silica in the human body causes hypothermia and a decrease in immunity, and a serious lack of silica means that life is maintained. It can be difficult.
  • silica can be ingested by general diet (especially Japanese food), but due to recent changes in eating habits (for example, away from Japanese food), the chances of ingesting grains rich in silica tend to decrease. is there. Further, even if the above food is taken, the absorption rate of silica by digestion is poor, and therefore the human body tends to always lack silica.
  • silica is preferably absorbed efficiently into the body in the form of supplements and silicon-containing health foods.
  • silica can be efficiently ingested regardless of the time and place of ingestion.
  • quartz is an insoluble mineral, there is a problem that even if silica is mixed into a beverage in the form of fine powder, it precipitates.
  • Patent Documents 1 and 2 research and development of beverages containing silica have been promoted (for example, Patent Documents 1 and 2), and various types of silica water are known (for example, Non-Patent Document 1).
  • silica used in conventional silica water is a colloidal silica synthesized from water glass (sodium silicate Na 2 SiO 3 ) derived from caustic soda, and has a structure of metasilicic acid H 2 SiO 3 . ..
  • Silica water that uses water glass derived from caustic soda as a raw material contains a large amount of Na (sodium ion) as shown in the analysis result of contained elements (FIG. 4) described later.
  • FOG. 4 analysis result of contained elements
  • the present invention has been made in view of such circumstances, and an object of the present invention is to provide silica water which is safe and has high efficacy as a healthy beverage.
  • the present invention which achieves the above object is characterized by including a silicate ion generation step of generating a silicate ion while generating fine bubbles of hydrogen by subjecting a material to be reacted having a surface made of at least a silicon simple substance to an alkali reaction. And a method for producing water-soluble nanocolloidal silica.
  • water glass derived from caustic soda sodium silicate Na 2 SiO 3
  • the content of Na (sodium ion) is suppressed in the produced water-soluble nanocolloidal silica, and a large amount is obtained. It does not remain. Therefore, it is possible to prevent the performance as a healthy drink from being deteriorated, and to prevent the human body of the ingestor from being adversely affected.
  • a water-soluble nanocolloidal silica which is a silica water having a high effect as a safe and healthy beverage.
  • the method before the step of producing silicate ions, silicon dioxide and carbon are heated, and at least the surface of the silicon dioxide is reacted with carbon to remove generated carbon dioxide gas. At the same time, it is preferable that the method further includes a step of producing a reacted material by reducing the silicon to a simple substance to produce the reacted material.
  • the silicon dioxide has a porous structure.
  • the present invention is also a water-soluble nanocolloidal silica produced by the above production method, which is characterized by having a negative zeta potential.
  • the zeta potential of the water-soluble nanocolloidal silica according to the present invention is preferably ⁇ 10 mV to ⁇ 90 mV.
  • the water-soluble nanocolloidal silica according to the present invention also preferably has a particle size in the range of 5 nm to 300 nm.
  • the method for producing water-soluble nanocolloidal silica according to the present invention is a silicate ion producing step of producing a silicate ion while causing fine reaction of a material to be reacted having a surface composed of at least a silicon simple substance with an alkali to generate fine hydrogen bubbles. including.
  • the silica water (water-soluble nanocolloidal silica) produced by this production method does not use water glass (sodium silicate Na 2 SiO 3 ) derived from caustic soda, which has been conventionally used as a raw material for silica water.
  • the content of Na (sodium ion) is at the level of the detection limit value, and even if it is contained, it is extremely low. Therefore, since Na (sodium ion) is not contained in a large amount in silica water (water-soluble nanocolloidal silica), deterioration of performance as a health drink is prevented, and silica water (water-soluble nanocolloidal silica) is also prevented. It is possible to prevent the human body of the person who took the product from adversely affecting it. As a result, it is possible to provide silica water (water-soluble nanocolloidal silica) that has a high effect as a safe and healthy beverage.
  • the water-soluble nanocolloidal silica produced by the production method of the present invention preferably has a structure of Si(OH) 4 orthosilicate.
  • Such water-soluble nanocolloidal silica also has a predetermined zeta potential, particle size, total scattering intensity, and the like, and becomes silica water excellent in antioxidant property and penetrability.
  • the total scattering intensity in the present invention assuming that the shape of the measured particle is a true sphere, was recalculated from the scattering intensity standard to the volume standard, and further to the number standard, using all the scattered light amounts obtained during the measurement.
  • the zeta potential in the present invention means a potential difference between a sliding surface in the electric double layer formed around the fine particles in the solution and a portion sufficiently separated from the interface. When the zeta potential approaches zero, the mutual repulsion of the particles weakens and eventually agglomerates.
  • the silicate ion producing step which constitutes the production method of the present invention is a step of producing a silicate ion while causing a material to be reacted having at least a surface made of a simple substance of silicon to undergo an alkali reaction to generate fine bubbles of hydrogen.
  • the material to be reacted used here is not particularly limited, and various known materials can be used. For example, single crystal silicon produced by the Czochralski method or the like may be used, and diatomaceous earth, silica, quartz powder such as quartz, or a material obtained by reducing the surface of a bulk by a method described below can also be used. ..
  • the simple substance of silicon refers to a substance mainly composed of single substance silicon, for example, a substance consisting of 90% by mass or more of single substance silicon.
  • high-purity silicon or the like for manufacturing Si chips is not always necessary, but various known substances can be used as a simple substance of silicon.
  • the crystal structure and the like are not particularly limited, and single crystal, polycrystal, and amorphous silicon can be used.
  • the alkali used in the silicate ion generation step it is preferable to use an alkaline aqueous solution containing no sodium ion in order to minimize the sodium content in the water-soluble nanocolloidal silica produced.
  • concentration of the alkaline aqueous solution is not particularly limited, but for example, from the viewpoint of accelerating the alkaline reaction in the silicate ion producing step, it is preferable to use a strong alkaline aqueous solution having a pH of 13 or more at the start of the silicate ion producing step. preferable.
  • the pH tends to decrease with the passage of time, and the production state of the water-soluble nanocolloidal silica can be grasped by the pH value.
  • the temperature during the reaction is also not particularly limited, but it is preferably 0 to 90° C., particularly 5 to 50° C.
  • silicate ions particularly orthosilicate ions SiO 4 4 ⁇ having a tetrahedral structure can be generated.
  • the silicate ion generation reaction from the simple substance of silicon proceeds even under neutral conditions, but from the viewpoint of reaction rate, it is practical to carry out the reaction under alkaline conditions.
  • silicate ions are generated in the aqueous solution, and the generated silicate ions mainly have a tetrahedral structure.
  • orthosilicic acid: Si(OH) 4 can be used to produce a stable water-soluble nanocolloidal silica having a particle size of about 5 to 300 nm, particularly about 10 to 250 nm.
  • the present invention reacts with fine bubbles of hydrogen and dissolved oxygen to generate a chemical species such as diatomaceous earth.
  • a chemical species such as diatomaceous earth.
  • the nanobubbles are bubbles having a number average diameter of less than 1 ⁇ m (micrometer).
  • the period for performing the silicate ion generation step is not particularly limited, and orthosilicate Si(OH) 4 is generated as the main silicic acid compound, and the particle size is about 5 to 300 nm, preferably about 10 to 250 nm. It may be for a period in which the water-soluble nanocolloidal silica of the present invention can be produced.
  • the period for performing the silicate ion generation step may be, for example, about 6 months.
  • the material to be reacted Prior to the step of producing silicate ions in the present invention, the material to be reacted may be subjected to pretreatment, for example, physical treatment such as crushing and washing, and chemical treatment such as hydrophilization and reprecipitation by surface treatment.
  • pretreatment for example, physical treatment such as crushing and washing, and chemical treatment such as hydrophilization and reprecipitation by surface treatment.
  • the silicate ion generation step in the present invention since the material to be reacted having a surface composed of at least silicon simple substance is used, when silicon dioxide such as silica powder is used as a starting material, at least the surface layer portion is reduced to simple substance silicon. There is a need to.
  • the reaction target material production process is a process utilizing a so-called carbon reduction method, and there are no particular restrictions on the raw materials and reaction conditions used therein.
  • the raw material silicon dioxide preferably has a porous structure, but is not limited thereto, and various commercially available silica powder, silicon dioxide such as quartz, and carbon such as charcoal and carbon black can be used.
  • a crystal (silicon dioxide SiO 2 ) and a carbonaceous material for example, charcoal such as charcoal and coal, a material containing carbon C as a main component such as carbon black
  • a reduction refining method is used, in which single crystal silicon (Si) having a purity of 99.9% is produced by heating to 0° C.
  • the temperature for heating the silicon dioxide SiO 2 and the carbon C is not limited to the above, and may be any temperature at which oxygen can be separated and removed from the silicon dioxide SiO 2 as carbon dioxide gas CO 2 to generate silicon. Good.
  • the water-soluble nanocolloidal silica of the present invention produced in this manner has almost no residual sodium ions and the like, and has high efficacy as a safe health drink.
  • the present invention also includes the water-soluble nanocolloidal silica produced by the production method as described above.
  • the water-soluble nanocolloidal silica of the present invention exhibits a negative zeta potential, and the value thereof is preferably ⁇ 10 mV to ⁇ 90 mV, more preferably ⁇ 30 mV to ⁇ 80 mV, and particularly preferably ⁇ 40 mV to ⁇ 70 mV.
  • the nanocolloidal silica of the present invention has the above negative zeta potential, so that the stable state can be maintained for a period of, for example, one year or more without causing precipitation. it can.
  • the particle size of the colloid is about 5 to 300 nm as described above, but it may be preferably in the range of 10 nm to 250 nm.
  • the water-soluble nanocolloidal silica of the present invention also exhibits characteristic physical properties such as total scattering intensity and dissolved concentration, and the silicate ion concentration in silica water is higher than that of conventional silica water, for example, 5000 mg/L or more. It is also possible to do so.
  • the pH of the water-soluble nanocolloidal silica of the present invention after production is about 10 to 12, often about 10 to 11, and particularly about 11. Although it does not adversely affect the gastrointestinal tract even if it is drunk in such an alkaline state, the pH can be lowered to 9 or less, for example, around 8 if desired. As will be shown in Examples described later, depending on the blood lipid, it may be more effective to reduce the ingestion by neutralizing the lipid to a pH of about 8.
  • the acid used for neutralization is not particularly limited, and various acids such as acetic acid, hydrochloric acid and citric acid can be used, but acetic acid is particularly preferable. It is also possible to use general-purpose vinegar.
  • test example 1 In the most general mode of producing the water-soluble nanocolloidal silica according to the present invention, first, a silicon simple substance producing step (step S1) is performed. By the reduction refining method as described above, silicon dioxide powder (particle size: about 50 to 300 ⁇ m) is heated together with carbon to, for example, 500 to 2500° C., preferably 500 to 2400° C. to remove oxygen as carbon dioxide gas. To produce simple silicon. Next, a silicate ion production process (step S2) is performed in which the produced silicon simple substance is alkali-reacted to produce hydrogen fine bubbles.
  • step S2 When step S2 is started in an alkaline aqueous solution having a pH of about 13 and left for a long time, for example, 6 months, the pH finally drops to about 10 and the transparent liquid becomes a whitened colloidal solution.
  • the zeta potential of the colloidal solution is a negative numerical value, precipitates such as cages do not occur.
  • FIG. 1 is a diagram showing the results of particle size distribution measurement of the water-soluble nanocolloidal silica of the present invention, and is a graph showing the scattering intensity for each particle size. As shown in FIG. 1, the particle size distribution formed a single peak. As described above, the water-soluble nanocolloidal silica of the present invention can have a fine particle size distribution with a single peak in a suitable range of particle size d of about 10 to 250 nm. Since the particle size of the conventional product is usually around 800 nm, the particle size (250 nm or less) of the water-soluble nanocolloidal silica of the present invention is remarkably small, about 1/4 or less of the particle size of the conventional product. I understand.
  • the zeta potential of the water-soluble nanocolloidal silica of the present invention can have a negative value, for example, ⁇ 10 mV to ⁇ 90 mV, and particularly ⁇ 45 to 55 mV.
  • FIG. 2 is a chart showing the results of contained element analysis of silica powder obtained by drying the water-soluble nanocolloidal silica of the present invention using EDX (energy dispersive X-ray spectroscopy).
  • the O (oxygen) content is 58.70% and the Si (silicon) content is 39.61%.
  • a trace amount of Na (sodium ion) is contained in the trace amount of contained elements.
  • the water-soluble nanocolloidal silica of the present invention does not contain a large amount of Na (sodium ion), deterioration of performance as a health drink is prevented and the water-soluble nanocolloidal silica of the present invention is ingested. It is possible to prevent the human body of the victim from being adversely affected. As a result, it is possible to provide silica water (water-soluble nanocolloidal silica) that has a high effect as a safe and healthy beverage.
  • FIG. 3 is a chart showing the results of performing elemental analysis of ultrafine quartz using EDX (energy dispersive X-ray spectroscopy).
  • the content ratio of O (oxygen) is 56.26%
  • the content ratio of Si (silicon) is 41.05%
  • other minute amounts of other contained elements are included.
  • a small amount of impurity level Na (sodium ion) is contained therein. Therefore, as in the case of the water-soluble nanocolloidal silica of the present invention, a large amount of Na (sodium ion) is not contained.
  • the ultra-fine grained quartz is merely quartz that is crushed into fine particles, so that the structure remains quartz SiO 2 .
  • quartz (quartz) is an insoluble mineral, and even if mixed in a beverage in the form of fine powder, it will precipitate. For this reason, ultra-fine crystal is not suitable for beverages.
  • FIG. 4 shows a silica powder obtained by drying colloidal silica, which is used as a conventional silica water and is synthesized from water glass (sodium silicate Na 2 SiO 3 ) derived from caustic soda as EDX (energy dispersive X It is a chart which shows the result at the time of carrying out contained element analysis using the line spectroscopy.
  • the conventional colloidal silica contains Na at a high concentration of 10%. Therefore, not only the performance of silica water as a health drink is low, but also the human body of a person who ingests silica water may be adversely affected.
  • the water-soluble nanocolloidal silica of the present invention has special characteristics different from conventional silica water and ultrafine crystal.
  • the water-soluble nanocolloidal silica of the present invention is also present in a colloidal solution state, unlike the above-mentioned ultrafine-grained quartz, and therefore, the Tyndall phenomenon is observed. That is, when light is passed through the water-soluble nanocolloidal silica of the present invention, the light is scattered and the light paths appear to shine uniformly.
  • Test example 2 [Examples 1 to 4 and Comparative Example]
  • the effect of the water-soluble nanocolloidal silica of the present invention produced as described above will be described with respect to the results of testing using rats.
  • the test was requested to an overseas university, and the water-soluble nanocolloidal silica of the present invention (hereinafter sometimes abbreviated as “silica water” under the conditions of room temperature 24° C. and relative humidity 40 to 50%. Silicon concentration 5660 mg/L , PH 10.93).
  • a neutralized product of the water-soluble nanocolloidal silica (the water-soluble nanocolloidal silica of the present invention neutralized with white vinegar, hereinafter referred to as "neutralized product", pH 8.05), distilled A test using water and simvastatin (a general-purpose drug for treating dyslipidemia, 5% CMC-Na preparation) was also conducted separately.
  • Fifty-six male rats weighing 160 ⁇ 10 g were randomly divided into the following 7 groups, and each of the following types and amounts of the drugs were intragastrically administered with 20 g of the feed daily.
  • the following drug amount is the mass (mg) of the drug pure component (silicon component etc.) per 1 kg of rat.
  • ⁇ 1 set (reference example): general feed + distilled water ⁇ 2 sets (control example): high fat feed + distilled water ⁇ 3 sets (comparative example): high fat feed + simvastatin 1.54 mg/kg ⁇ 4 sets (Example 1): high-fat feed + silica water 10.94 mg/kg ⁇ 5 sets (Example 2): high-fat feed + silica water 5.47 mg/kg ⁇ 6 sets (Example 3): high-fat feed + silica water 2.83 mg/kg ⁇ 7 sets (Example 4): High-fat feed+neutralized product 10.94 mg/kg After administration of each of the above drugs for 15 days, water was given for 15 more days without feeding, and serum was collected, and TC (total cholesterol), TG (triglyceride), LDL-C was measured by a fully automated biochemical analyzer. (Bad cholesterol), HDL-C (good cholesterol), AST and ALT values were measured. Table 2 shows the average values of the measurement results for 8 animals in each group
  • Example 2 As shown in Table 2, in Examples 1 to 4 in which silica water was administered to rats, the total cholesterol level, TG, LDL-C, AST, and ALT were higher than those in the control example in which distilled water was administered to rats. It was found that the water-soluble nanocolloidal silica of the present invention has an effect of reducing blood fat. Particularly in regard to TG and ALT, all of Examples 1 to 4 showed excellent effects even compared with the comparative example in which the general drug for treating dyslipidemia was administered to rats, and the value of ALT was fed with the general diet. It was lower than the reference example. On the other hand, the HDL-C (good cholesterol) values of Examples 1 to 4 were equal to or higher than those of the control and comparative examples. In addition, among Examples 1 to 4, Example 4, which uses a neutralized product having a pH of about 8, has the highest effect of reducing the total cholesterol value and LDL-C value and the effect of improving the HDL-C value. It was
  • Example 5 To test the acute toxicity of the water-soluble nanocolloidal silica of the present invention, the same number of male and female mice weighing 20 ⁇ 1.5 g was orally administered with silica water. The test was conducted at a university overseas under conditions of a temperature of 20 to 23° C. and a relative humidity of 70%. 0.77 ml of the above silica water was administered to each of 20 mice 4 times during 24 hours (dose of silicon per mouse: 17.4 mg). None of the animals died and the half-lethal dose ID50 was not obtained. Next, the dose to mice was increased, but no death occurred even at the maximum dose of 870 mg/kg (363 times the human clinical dose).
  • the use of the water-soluble nanocolloidal silica of the present invention as a beverage has been described, but the water-soluble nanocolloidal silica of the present invention is not limited to use as a beverage.
  • the water-soluble nanocolloidal silica of the present invention has excellent ability in terms of bactericidal activity, detergency, penetration ability, anti-inflammatory ability, cell activation ability, antioxidant ability, degrading ability, etc. It can be used for various purposes.
  • the water-soluble nanocolloidal silica of the present invention has a bactericidal power to instantaneously sterilize Legionella bacteria and Escherichia coli, and a cleaning power to wash away environmental pollutants attached to the surface of food or permeated into the interior thereof, and 2.5 billion minutes. It has a penetrating power that can be subdivided into units of 1 m (meter). In addition, it has an anti-inflammatory ability to extinguish inflammation by strengthening immunity and a cell activation ability to directly enter energy into the cell nucleus to activate the cell. In addition, it dissolves stains and qualities in blood vessels, repairs blood vessels, and stops the progression of intestinal rot to kill bad bacteria and activate good bacteria to strengthen immunity. Has oxidative power.
  • the water-soluble nanocolloidal silica of the present invention has a good effect on human health, but also has the following effects. That is, since the water-soluble nanocolloidal silica of the present invention has an effect of eliminating waste products, constipation, swelling (water poisoning), and water accumulation in joints can be eliminated. It also has the effect of eliminating toxins in the heart, such as stress, depression and insomnia. It also has the effect of improving stiff shoulders, headache, backache, dizziness, numbness and the like.
  • the water-soluble nanocolloidal silica of the present invention has an effect of delaying oxidation, by using it for washing vegetables and fruits, it is possible to maintain the freshness of vegetables and fruits more than washing with tap water. Due to the excellent penetrating power of the water-soluble nanocolloidal silica of the present invention, it is possible to remove pesticides and the like that have penetrated inside vegetables. Specifically, for example, when a cherry tomato cultivated using a pesticide is immersed in water obtained by mixing the water-soluble nanocolloidal silica of the present invention and water, the pesticide exudes from the cherry tomato and the cherry tomato is soaked. The water turns yellow.
  • water-soluble nanocolloidal silica of the present invention when the water-soluble nanocolloidal silica of the present invention is attached to raw materials such as seafood, it becomes difficult for bacteria and the like to adhere to the portion to which the water-soluble nanocolloidal silica is attached. Can be maintained for a long time.
  • the water-soluble nanocolloidal silica of the present invention may be used for cooking rice, cooking dishes such as pots and stews.
  • the excellent permeation power of the water-soluble nanocolloidal silica removes the oxidizing substances inside the rice, so that the rice can be transformed into delicious rice.
  • the addition of the water-soluble nanocolloidal silica of the present invention to coffee has an effect of removing bitterness and mellow taste.
  • the water-soluble nanocolloidal silica of the present invention is used for brewing green tea, it also has the effect that the color of green tea becomes darker than when brewing with tap water.
  • the water-soluble nanocolloidal silica of the present invention brings out the effect of bringing out the taste of the material and making it delicious when added to the dish. Furthermore, since the water-soluble nanocolloidal silica of the present invention decomposes oil, it has an effect not only of taste but also of making a dish healthy.
  • the water-soluble nanocolloidal silica of the present invention is effective in addition to human diet. For example, by adding a few drops of water-soluble nanocolloidal silica to drinking water or food for pets such as dogs and cats, or spraying diluted water-soluble nanocolloidal silica on the pet's body, the effect of improving the coat of hair and odor Has the effect of suppressing.
  • the foliage plant can be kept fresh and its life can be extended. In the case of fresh flowers, the flowering period can be extended.
  • the water-soluble nanocolloidal silica of the present invention has excellent alcohol decomposing ability, it is also effective for a hangover.
  • the water-soluble nanocolloidal silica of the present invention has an effect of removing active oxygen and thus has a cosmetic effect.
  • the cosmetic component of water-soluble nanocolloidal silica can be effectively permeated into the skin. It is also possible to effectively remove spots, wrinkles, acne, and pimples by directly applying a stock solution of water-soluble nanocolloidal silica to the skin.
  • water-soluble nanocolloidal silica of the present invention when used for toothpaste, it is possible to remove tea astringency and tar adhering to teeth due to the adsorption effect of silicon, and to eliminate periodontal disease, gingivitis and hyperesthesia. Can also
  • water-soluble nanocolloidal silica of the present invention can be used in the fields of agriculture, fisheries, medical fields, etc.
  • water-soluble nanocolloidal silica can be used as fertilizer
  • water-soluble nanocolloidal silica can be used as feed.
  • the water-soluble nanocolloidal silica of the present invention In the medical field, by ingesting the water-soluble nanocolloidal silica of the present invention in patients, it has the effect of improving atopy, pollinosis, asthma, cerebral infarction, myocardial infarction, renal failure (uremia) and the like. Furthermore, the water-soluble nanocolloidal silica can be used for treating cancer such as prostate cancer, uterine cancer, and colon cancer. Specifically, for example, water-soluble nanocolloidal silica can be used for cancer immunotherapy with near infrared rays (developed by Senior Researcher Hisashi Takashi Kobayashi, National Cancer Institute).
  • phthalocyanine which is a dye that causes a chemical reaction by near-infrared rays, is attached to an antibody that specifically binds to cancer cells and then injected intravenously into the patient's body.
  • phthalocyanine since phthalocyanine is not water-soluble, it cannot be put into the patient's body, but it becomes water-soluble by adding the water-soluble nanocolloidal silica of the present invention to phthalocyanine. Since the antibody that has entered the body binds to cancer cells, when this binding area is irradiated with near infrared light, it causes a chemical reaction to destroy the cancer cells. Further, the water-soluble nanocolloidal silica of the present invention can be used alone for cancer treatment.
  • the water-soluble nanocolloidal silica of the present invention activates mitochondria in cancer cells and produces an enzyme (cytochrome C) in mitochondria.
  • the enzyme (cytochrome C) activates the action of a proteolytic enzyme (caspase) that causes apoptosis (suicide) in cancer cells.
  • caspase a proteolytic enzyme
  • the DNA (deoxyribonucleic acid) of the cancer cells undergoes degeneration of apoptosis and the disappearance of the cancer cells begins.
  • the water-soluble nanocolloidal silica of the present invention has a small particle size, it can be used in artificial dialysis and the like.
  • the water-soluble nanocolloidal silica of the present invention has advantages that it does not cause a large amount of sodium ions to remain and that it does not precipitate for a long period of time.
  • INDUSTRIAL APPLICABILITY The present invention has made it possible to provide silica water that has high efficacy as a safe and healthy beverage.

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PCT/JP2020/006600 2019-02-19 2020-02-19 水溶性ナノコロイドシリカの製造方法、及び水溶性ナノコロイドシリカ Ceased WO2020171132A1 (ja)

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JP2023191562A JP2024023263A (ja) 2019-02-19 2023-11-09 水溶性ナノコロイドシリカの製造方法、及び水溶性ナノコロイドシリカ

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JPS56140022A (en) * 1980-03-26 1981-11-02 Union Carbide Corp Low density body of prepared mixture for use in manufacture of silicon and ferrosilicon
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