WO2020134112A1 - 具有多频率模式的植入式神经刺激设备 - Google Patents

具有多频率模式的植入式神经刺激设备 Download PDF

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WO2020134112A1
WO2020134112A1 PCT/CN2019/100391 CN2019100391W WO2020134112A1 WO 2020134112 A1 WO2020134112 A1 WO 2020134112A1 CN 2019100391 W CN2019100391 W CN 2019100391W WO 2020134112 A1 WO2020134112 A1 WO 2020134112A1
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pulse
frequency
control circuit
frequency mode
different
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French (fr)
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马伯志
郝红伟
李路明
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Tsinghua University
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Tsinghua University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36125—Details of circuitry or electric components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36171—Frequency

Definitions

  • the present invention relates to the field of implantable medical devices, and in particular to an implantable nerve stimulation device with multiple frequency modes.
  • Implanted nerve stimulators generally have multiple stimulation contacts, and can output multiple sets of parameter combination stimulation pulses. Each group of stimulation pulses can be set with different stimulation contact combinations, so as to generate different stimulation signals for multiple locations. That is to stimulate multiple different parts at the same time.
  • different therapies have different numbers of stimulation sites.
  • the number of stimulation sites may be 2, 4, 6, or even more.
  • the deep brain electrical stimulator generally at least two stimulation parts of the left and right brain, or two stimulation channels, are required.
  • the frequencies of different stimulation sites (such as the left and right brains of deep brain stimulation) need to be the same, that is, the output frequencies of different sets of stimulation pulses are the same.
  • an implantable nerve stimulation device with multiple frequency modes including:
  • the signal output circuit is used to output multiple groups of pulse signals according to the multiple different pulse frequencies in the independent frequency mode, wherein the pulse frequencies of the pulse signals of different groups are different, and according to the The only pulse frequency outputs multiple groups of pulse signals, in which the pulse frequency of each group of pulse signals is the same.
  • control circuit includes:
  • Multiple frequency registers are used to store different pulse frequencies
  • Multiple sequential logic control circuits are used to provide pulse frequencies according to different frequency registers.
  • the signal output circuit includes:
  • Multiple stimulation signal output modules respectively output multiple sets of stimulation signals through corresponding electrodes according to different pulse frequencies provided by the sequential logic control circuit.
  • control circuit selects a sequential logic control circuit and a frequency register in the same frequency mode; the selected sequential logic control circuit provides a unique pulse frequency according to the selected frequency register.
  • the signal output circuit includes:
  • Multiple stimulation signal output modules output multiple sets of stimulation signals through corresponding electrodes according to the unique pulse frequency provided by the selected sequential logic control circuit.
  • control circuit is also used to provide pulse parameters and multiple sets of pulse parameters in the independent frequency mode
  • the signal output circuit sets each pulse signal in each group of pulse signals according to the multiple groups of pulse parameters.
  • control circuit includes:
  • a plurality of pulse parameter registers respectively used to store the pulse parameters of the multiple groups of pulse signals
  • Multiple sequential logic control circuits are used to set each pulse signal in each group of pulse signals according to different pulse parameter registers.
  • control circuit provides multiple sets of pulse parameters in the same frequency mode
  • the signal output circuit sets each pulse signal in each group of pulse signals according to the multiple groups of pulse parameters.
  • control circuit includes:
  • a plurality of pulse parameter registers respectively used to store the pulse parameters of the multiple groups of pulse signals
  • a plurality of sequential logic control circuits select a sequential logic control circuit under the same frequency mode, and the selected sequential logic control circuit is used to set each pulse signal in each group of pulse signals according to different pulse parameter registers.
  • the output time of pulse signals of different groups is different.
  • the control circuit can determine the frequency mode, provide multiple different pulse frequencies in the independent frequency mode, and provide a unique pulse frequency in the same frequency mode, so that the signal output circuit can Output multiple sets of pulse signals with different frequencies, or multiple sets of pulse signals with the same frequency. This is compatible with independent frequency mode and the same frequency mode to meet different clinical needs.
  • FIG. 1 is a schematic structural diagram of an implantable nerve stimulation device provided by an embodiment of the present invention.
  • FIG. 2 is a schematic structural diagram of a multi-contact stimulation circuit in an independent frequency mode according to an embodiment of the present invention
  • FIG. 3 is a schematic diagram of two sets of pulse signals in an embodiment of the present invention.
  • FIG. 4 is a schematic structural diagram of a multi-contact stimulation circuit in the same frequency mode in an embodiment of the present invention.
  • connection should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or a whole Ground connection; it can be mechanical connection or electrical connection; it can be directly connected or indirectly connected through an intermediary, or it can be an internal connection between two components, it can be a wireless connection or a wired connection.
  • connection should be understood in specific situations.
  • Embodiments of the present invention provide an implantable nerve stimulation device with multiple frequency modes, which may specifically be a deep brain electrical stimulator or a spinal cord stimulator.
  • the device includes a communication circuit 11, a power management circuit 12, a microcontroller 13 and a multi-contact stimulation circuit 14, and the like, wherein the communication circuit 11 can be wirelessly connected to an extracorporeal device and receive setting instructions; a microcontroller 13 is used to set the multi-contact stimulation circuit 14 according to the setting instruction.
  • the multi-contact stimulation circuit 14 includes a control circuit 141 and a signal output circuit 142.
  • the signal output circuit 142 is connected to n electrodes, and a stimulation signal (voltage/current) is sent out through the electrodes to implement therapy.
  • the user can use an extracorporeal device to send a frequency mode command to make the implanted nerve stimulation device work in an independent frequency mode or in the same frequency mode.
  • the control circuit 141 is used to determine the frequency mode. When it is determined as the independent frequency mode, a plurality of different pulse frequencies are provided. There are at least two pulse frequencies in the independent frequency mode, which can be set according to the electrode grouping in actual application. In this embodiment, the n electrodes are divided into 2 groups. In the independent frequency mode, the control circuit 141 can provide two different pulse frequencies f1 and f2. In other embodiments, the electrode grouping may be more than two, and the number of alternative pulse frequencies N is at least 2. A preferred solution is that N is equal to the number of electrode groupings; when the same frequency mode is determined, the control circuit 141 Only one pulse frequency f1 or f2 is provided.
  • the signal output circuit 142 is used to output multiple groups of pulse signals according to a plurality of different pulse frequencies in an independent frequency mode, where the pulse frequencies of the pulse signals of different groups are different.
  • the signal output circuit 142 in the independent frequency mode will output the first group of pulse signals through the electrode 1...electrode n/2 (first group of electrodes) with a frequency of f1; through the electrode n/2+1...
  • Electrode n (second set of electrodes) outputs a second set of pulse signals with a frequency of f2.
  • the frequency of the first group of pulse signals and the second group of pulse signals are independent, and the frequency of the pulse signals in the same group may be the same.
  • the signal output circuit 142 will also output the first group of pulse signals through electrode 1...electrode n/2 (first group of electrodes), and output through electrode n/2+1...electrode n (second group of electrodes) The second group of pulse signals.
  • the frequency of the two sets of pulse signals is the same, for example, the frequency is f1 or f2.
  • the control circuit can determine the frequency mode, provide multiple different pulse frequencies in the independent frequency mode, and provide a unique pulse frequency in the same frequency mode, so that the signal output circuit can Output multiple sets of pulse signals with different frequencies, or multiple sets of pulse signals with the same frequency. This is compatible with independent frequency mode and the same frequency mode to meet different clinical needs.
  • the control circuit 141 includes a frequency mode register 1410, a first frequency register 1411, a second frequency register 1412, a first sequential logic control circuit 1413, and a second sequential logic control circuit 1414.
  • the frequency mode register 1410 is used to set the frequency output mode of different pulse groups
  • the first frequency register 1411 is used to store the pulse frequency value f1
  • the second frequency register 1412 is used to store the pulse frequency value f2.
  • the first frequency register 1411 corresponds to the first sequential logic control circuit 1413
  • the second frequency register 1412 corresponds to the second sequential logic control circuit 1414.
  • the signal output circuit 142 includes a first stimulation signal output module 1421 and a second stimulation signal output module 1422.
  • the first stimulation signal output module 1421 is connected to electrode 1... electrode 2/n (first group of electrodes), and the second stimulation signal output module 1422 is connected to electrode 2/n+1... electrode n (second group of electrodes).
  • the first stimulation signal output module 1421 corresponds to the first sequential logic control circuit 1413
  • the second stimulation signal output module 1422 corresponds to the second sequential logic control circuit 1414.
  • the first sequential logic control circuit 1413 causes the first stimulation signal output module 1421 to output the first group of pulses AP1-AP2-AP3-AP1-AP2-AP3..., which can be output at equal intervals and the frequency is f1 (phase (The reciprocal of the time interval T1 between adjacent pulses AP1, adjacent AP2, and adjacent AP3); the second sequential logic control circuit 1414 causes the second stimulation signal output module 1422 to output a second group of pulses BP1-BP2-BP1- BP2... may be output at equal intervals, and the frequency is f2 (the reciprocal of the time interval T2 between adjacent pulses BP1 and adjacent BP2).
  • the pulse frequencies output by the first stimulation signal output module 1421 and the second stimulation signal output module 1422 are independent of each other, but do not simultaneously output pulse signals.
  • control circuit 141 is also used to provide pulse parameters.
  • the control circuit 141 provides multiple sets of pulse parameters in an independent frequency mode, such as 2, 4, 6, and 8 sets of pulse parameters.
  • the signal output circuit 142 sets each pulse signal in each group of pulse signals according to multiple groups of pulse parameters.
  • control circuit 141 further includes a plurality of pulse parameter registers, which are respectively used to store pulse parameters of multiple sets of pulse signals, and the pulse parameters may include pulse polarity, amplitude, and width.
  • pulse parameters may include pulse polarity, amplitude, and width.
  • pulse 1-3 parameter register 1431 used to store the parameters of the first group of pulses
  • pulse 4-6 parameter register 1432 used to store the parameters of the second group of pulses.
  • the first sequential logic control circuit 1413 sets the first group of pulses according to the parameters in the pulse 1-3 parameter register 1431; the second sequential logic control circuit 1414 sets the second group of pulses according to the pulse 4-6 parameter register 1432. In this way, the frequencies of the first group of pulses and the second group of pulses are independent of each other, and stimulation pulses of multiple sets of parameter combinations can be output separately.
  • the implanted nerve stimulation device provided by the present invention can also output multiple sets of pulse signals with the same frequency.
  • the following describes the working mode in the same frequency mode with reference to FIG. 4.
  • the selected sequential logic control circuit provides a unique pulse frequency according to the selected frequency register.
  • the multiple stimulation signal output modules output multiple sets of stimulation signals through corresponding electrodes according to the unique pulse frequency provided by the selected sequential logic control circuit.
  • the first frequency register 1411, the first stimulation signal output module 1421 and the second stimulation signal output module 1422 correspond to the first sequential logic control circuit 1413, and the second sequential logic control circuit 1414 and the second frequency register 1412 are closed and not used.
  • Both sets of pulse output are controlled by the first sequential logic control circuit 1413, and pulse signals can be output at equal intervals.
  • the frequency of the two groups of pulses is the same f1, so that the same frequency stimulation of the two parts is achieved.
  • control circuit 141 can also provide multiple sets of pulse parameters, such as 2, 4, 6, and 8 sets of pulse parameters.
  • the signal output circuit 142 sets each pulse signal in each group of pulse signals according to multiple groups of pulse parameters.
  • control circuit includes a plurality of pulse parameter registers, which are respectively used to store pulse parameters of multiple sets of pulse signals.
  • all the pulse parameter registers correspond to the selected sequential logic control circuit, which is the first sequential logic control circuit 1413 in this embodiment.
  • the first sequential logic control circuit 1413 sets each pulse signal in each group of pulse signals according to different pulse parameter registers.
  • the control circuit can select a sequential logic control circuit to provide a unique pulse frequency in the same frequency mode, so that the signal output circuit outputs multiple sets of the same frequency according to the unique pulse frequency
  • the pulse signal is compatible with the independent frequency mode and the same frequency mode to meet different clinical needs.
  • the embodiments of the present invention may be provided as methods, systems, or computer program products. Therefore, the present invention may take the form of an entirely hardware embodiment, an entirely software embodiment, or an embodiment combining software and hardware. Moreover, the present invention may take the form of a computer program product implemented on one or more computer usable storage media (including but not limited to disk storage, CD-ROM, optical storage, etc.) containing computer usable program code.
  • computer usable storage media including but not limited to disk storage, CD-ROM, optical storage, etc.
  • each flow and/or block in the flowchart and/or block diagram and a combination of the flow and/or block in the flowchart and/or block diagram may be implemented by computer program instructions.
  • These computer program instructions can be provided to a general-purpose computer, special-purpose computer, embedded processor, or other programmable data processing device's microcontroller to produce a machine that causes instructions to be executed by the computer or other programmable data processing device's microcontroller Means for generating the functions specified in a block or blocks of a flowchart or a flow and/or a block diagram.
  • These computer program instructions may also be stored in a computer readable memory that can guide a computer or other programmable data processing device to work in a specific manner, so that the instructions stored in the computer readable memory produce an article of manufacture including an instruction device, the instructions
  • the device implements the functions specified in one block or multiple blocks of the flowchart one flow or multiple flows and/or block diagrams.
  • These computer program instructions can also be loaded onto a computer or other programmable data processing device, so that a series of operating steps are performed on the computer or other programmable device to produce computer-implemented processing, which is executed on the computer or other programmable device
  • the instructions provide steps for implementing the functions specified in one block or multiple blocks of the flowchart one flow or multiple flows and/or block diagrams.

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Abstract

一种具有多频率模式的植入式神经刺激设备，包括控制电路（141），用于确定频率模式，所述频率模式包括独立频率模式和相同频率模式，在所述独立频率模式下提供多个不同的脉冲频率、在所述相同频率模式下提供唯一的脉冲频率；信号输出电路（142），用于在所述独立频率模式下根据所述多个不同的脉冲频率输出多组脉冲信号，其中不同组的脉冲信号的脉冲频率不相同，在所述相同频率模式下根据所述唯一的脉冲频率输出多组脉冲信号，其中各组脉冲信号的脉冲频率相同。

Description

具有多频率模式的植入式神经刺激设备 技术领域
本发明涉及植入式医疗设备领域，具体涉及一种具有多频率模式的植入式神经刺激设备。
背景技术
植入式神经刺激器一般具有多个刺激触点，能够输出多组参数组合的刺激脉冲，每组刺激脉冲可以设定不同的刺激触点组合，从而实现对多个部位产生不同的刺激信号，也就是同时刺激多个不同部位。
临床应用上不同的疗法有不同个数的刺激部位需求，刺激部位数量可能为2个、4个、6个甚至更多。以脑深部电刺激器为例，一般至少需要左右脑两个刺激部位，或者称为两个刺激通道。大多数情况下，不同刺激部位(比如脑深部电刺的左右脑)的频率需要一致，也即不同组刺激脉冲的输出频率是相同的。
随着临床研究的深入，有迹象表明有些情况下不同刺激部位采用不同的刺激频率可能会产生不同的效果。而现有的植入式医疗设备中只设置一个时序控制电路，顺序输出不同参数的刺激脉冲，无法实现同时输出多组频率不同的刺激脉冲。
发明内容
有鉴于此，本发明提供一种具有多频率模式的植入式神经刺激设备，包括：
控制电路，用于确定频率模式，所述频率模式包括独立频率模式和相同频率模式，在所述独立频率模式下提供多个不同的脉冲频率、在所述相同频率模式下提供唯一的脉冲频率；
信号输出电路，用于在所述独立频率模式下根据所述多个不同的脉冲频率输出多组脉冲信号，其中不同组的脉冲信号的脉冲频率不相同，在所述相同频率模式下根据所述唯一的脉冲频率输出多组脉冲信号，其中各组脉冲信号的脉冲频率相同。
可选地，所述控制电路包括：
多个频率寄存器，分别用于存储不同的脉冲频率；
多个时序逻辑控制电路，分别用于根据不同的所述频率寄存器提供脉冲频率。
可选地，信号输出电路包括：
多个刺激信号输出模块，分别根据不同的所述时序逻辑控制电路提供的脉冲频率通过相应的电极输出多组刺激信号。
可选地，所述控制电路在所述相同频率模式下选定一个时序逻辑控制电路，以及选定一个频率寄存器；选定的时序逻辑控制电路根据选定的频率寄存器提供唯一的脉冲频率。
可选地，信号输出电路包括：
多个刺激信号输出模块，根据选定的时序逻辑控制电路提供的唯一的脉冲频率通过相应的电极输出多组刺激信号。
可选地，所述控制电路还用于提供脉冲参数，在所述独立频率模式下提供多组脉冲参数；
所述信号输出电路根据所述多组脉冲参数设置各组脉冲信号中的各个脉冲信号。
可选地，所述控制电路包括：
多个脉冲参数寄存器，分别用于存储所述多组脉冲信号的脉冲参数；
多个时序逻辑控制电路，分别用于根据不同的脉冲参数寄存器设置各组脉冲信号中的各个脉冲信号。
可选地，所述控制电路在所述相同频率模式下提供多组脉冲参数；
所述信号输出电路根据所述多组脉冲参数设置各组脉冲信号中的各个脉冲信号。
可选地，所述控制电路包括：
多个脉冲参数寄存器，分别用于存储所述多组脉冲信号的脉冲参数；
多个时序逻辑控制电路，在所述相同频率模式下，选定一个时序逻辑控制电路，选定的时序逻辑控制电路用于根据不同的脉冲参数寄存器设置各组脉冲信号中的各个脉冲信号。
可选地，在所述独立频率模式下，不同组的脉冲信号的输出时间不相同。
根据本发明实施例提供的植入式神经刺激设备，控制电路可以确定频率模式，在独立频率模式下提供多个不同的脉冲频率、在相同频率模式下提供唯一的脉冲频率，使得信号输出电路可以输出多组频率不同的脉冲信号、也可以输出多组频率一致的脉冲信号。由此兼容独立频率模式和相同 频率模式，满足不同的临床需求。
附图说明
为了更清楚地说明本发明具体实施方式或现有技术中的技术方案，下面将对具体实施方式或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图是本发明的一些实施方式，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。
图1为本发明实施例提供的植入式神经刺激设备结构示意图；
图2为本发明实施例中独立频率模式下的多触点刺激电路的结构示意图；
图3为本发明实施例中两组脉冲信号的示意图；
图4为本发明实施例中相同频率模式下的多触点刺激电路的结构示意图。
具体实施方式
下面将结合附图对本发明的技术方案进行清楚、完整地描述，显然，所描述的实施例是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
在本发明的描述中，需要说明的是，术语“第一”、“第二”、仅用于描 述目的，而不能理解为指示或暗示相对重要性。
在本发明的描述中，需要说明的是，除非另有明确的规定和限定，术语“相连”、“连接”应做广义理解，例如，可以是固定连接，也可以是可拆卸连接，或一体地连接；可以是机械连接，也可以是电连接；可以是直接相连，也可以通过中间媒介间接相连，还可以是两个元件内部的连通，可以是无线连接，也可以是有线连接。对于本领域的普通技术人员而言，可以具体情况理解上述术语在本发明中的具体含义。
此外，下面所描述的本发明不同实施方式中所涉及的技术特征只要彼此之间未构成冲突就可以相互结合。
本发明实施例提供一种具有多频率模式的植入式神经刺激设备，具体可以是脑深部电刺激器或者脊髓刺激器等。如图1所示，该设备包括通信电路11、电源管理电路12、微控制器13和多触点刺激电路14等部件，其中通信电路11可以与体外设备无线连接，接收设置指令；微控制器13用于根据设置指令对多触点刺激电路14进行设置。
其中多触点刺激电路14包括控制电路141和信号输出电路142，信号输出电路142连接n个电极，通过电极发出刺激信号(电压/电流)实现疗法。在本实施例中，用户可以使用体外设备发送频率模式指令，使植入式神经刺激设备在独立频率模式下工作或者在相同频率模式下工作。
控制电路141用于确定频率模式，当确定为独立频率模式时，提供多个不同的脉冲频率。独立频率模式下的脉冲频率至少有两个，实际应用时可根据电极的分组进行设定。在本实施例中n个电极被分为2组，在独立 频率模式下，控制电路141可提供两个不同的脉冲频率f1和f2。在其它实施例中，电极的分组可以多于两个，备选的脉冲频率数量N至少为2，一种优选的方案是N等于电极的分组数量；当确定为相同频率模式时，控制电路141只提供一个脉冲频率f1或者f2。
信号输出电路142用于在独立频率模式下根据多个不同的脉冲频率输出多组脉冲信号，其中不同组的脉冲信号的脉冲频率不相同。在本实施例中，独立频率模式下信号输出电路142将通过电极1……电极n/2(第一组电极)输出第一组脉冲信号，频率为f1；通过电极n/2+1……电极n(第二组电极)输出第二组脉冲信号，频率为f2。第一组脉冲信号和第二组脉冲信号的频率是独立的，而同组内的脉冲信号频率可以是一致的。
相同频率模式下信号输出电路142也将通过电极1……电极n/2(第一组电极)输出第一组脉冲信号、通过电极n/2+1……电极n(第二组电极)输出第二组脉冲信号。此模式下这两组脉冲信号的频率相同，例如频率均为f1或者f2。
根据本发明实施例提供的植入式神经刺激设备，控制电路可以确定频率模式，在独立频率模式下提供多个不同的脉冲频率、在相同频率模式下提供唯一的脉冲频率，使得信号输出电路可以输出多组频率不同的脉冲信号、也可以输出多组频率一致的脉冲信号。由此兼容独立频率模式和相同频率模式，满足不同的临床需求。
在一个具体的实施例中，如2所示控制电路141包括频率模式寄存器1410、第一频率寄存器1411、第二频率寄存器1412、第一时序逻辑控制电路1413和第二时序逻辑控制电路1414。
其中频率模式寄存器1410用于设定不同脉冲组的频率输出模式；
第一频率寄存器1411用于存储脉冲频率值f1、第二频率寄存器1412用于存储脉冲频率值f2。
当通过频率模式寄存器1410设置为独立频率模式时，第一频率寄存器1411对应到第一时序逻辑控制电路1413、第二频率寄存器1412对应到第二时序逻辑控制电路1414。
信号输出电路142包括第一刺激信号输出模块1421和第二刺激信号输出模块1422。第一刺激信号输出模块1421连接电极1……电极2/n(第一组电极)、第二刺激信号输出模块1422连接电极2/n+1……电极n(第二组电极)。
独立频率模式下，第一刺激信号输出模块1421对应到第一时序逻辑控制电路1413、第二刺激信号输出模块1422对应到第二时序逻辑控制电路1414。
如图3所示，第一时序逻辑控制电路1413使第一刺激信号输出模块1421输出第一组脉冲AP1-AP2-AP3-AP1-AP2-AP3…，可以是等间隔输出，频率为f1(相邻的脉冲AP1、相邻的AP2、相邻的AP3之间的时间间隔T1的倒数)；第二时序逻辑控制电路1414使第二刺激信号输出模块1422输出第二组脉冲BP1-BP2-BP1-BP2…，可以是等间隔输出，频率为f2(相邻的脉冲BP1、相邻的BP2之间时间间隔T2的倒数)。
在本实施例中，第一刺激信号输出模块1421和第二刺激信号输出模块1422输出的脉冲频率相互独立，但不同时输出脉冲信号。
在一个优选的实施例中，控制电路141还用于提供脉冲参数。控制电 路141在独立频率模式下提供多组脉冲参数，例如2、4、6、8组脉冲参数。信号输出电路142根据多组脉冲参数设置各组脉冲信号中的各个脉冲信号。
在一个具体的实施例中，控制电路141还包括多个脉冲参数寄存器，分别用于存储多组脉冲信号的脉冲参数，脉冲参数可包括脉冲极性、幅度和宽度等。如2所示，本实施例中有脉冲1-3参数寄存器1431(用于存储第一组脉冲的参数)和脉冲4-6参数寄存器1432(用于存储第二组脉冲的参数)。
第一时序逻辑控制电路1413根据脉冲1-3参数寄存器1431中的参数设定第一组脉冲；第二时序逻辑控制电路1414根据脉冲4-6参数寄存器1432设定第二组脉冲。由此实现第一组脉冲和第二组脉冲频率相互独立，并且能够分别输出多组参数组合的刺激脉冲。
本发明提供的植入式神经刺激设备也可以输出频率相同的多组脉冲信号。下面结合图4介绍相同频率模式下的工作方式。
在相同频率模式下，选定一个时序逻辑控制电路，以及选定一个频率寄存器。选定的时序逻辑控制电路根据选定的频率寄存器提供唯一的脉冲频率。多个刺激信号输出模块均根据选定的时序逻辑控制电路提供的唯一的脉冲频率通过相应的电极输出多组刺激信号。
具体地，第一频率寄存器1411、第一刺激信号输出模块1421和第二刺激信号输出模块1422均对应到第一时序逻辑控制电路1413，第二时序逻辑控制电路1414和第二频率寄存器1412关闭不用。两组脉冲输出均由第一时序逻辑控制电路1413控制，可以等间隔输出脉冲信号。两组脉冲的频率一致均为f1，从而实现两个部位的相同频率刺激。
在相同频率模式下，控制电路141也可提供多组脉冲参数，例如2、4、6、8组脉冲参数。信号输出电路142根据多组脉冲参数设置各组脉冲信号中的各个脉冲信号。
在一个具体的实施例中，控制电路包括多个脉冲参数寄存器，分别用于存储多组脉冲信号的脉冲参数。在相同频率模式下，所有的脉冲参数寄存器都对应到选定的时序逻辑控制电路，在本实施例中是第一时序逻辑控制电路1413。第一时序逻辑控制电路1413根据不同的脉冲参数寄存器设置各组脉冲信号中的各个脉冲信号。
根据本发明实施例提供的植入式神经刺激设备，控制电路可以在相同频率模式下选定一个时序逻辑控制电路提供唯一的脉冲频率，使得信号输出电路根据唯一的脉冲频率输出多组频率相同的脉冲信号，兼容独立频率模式和相同频率模式，满足不同的临床需求。
本领域内的技术人员应明白，本发明的实施例可提供为方法、系统、或计算机程序产品。因此，本发明可采用完全硬件实施例、完全软件实施例、或结合软件和硬件方面的实施例的形式。而且，本发明可采用在一个或多个其中包含有计算机可用程序代码的计算机可用存储介质(包括但不限于磁盘存储器、CD-ROM、光学存储器等)上实施的计算机程序产品的形式。
本发明是参照根据本发明实施例的方法、设备(系统)、和计算机程序产品的流程图和/或方框图来描述的。应理解可由计算机程序指令实现流程图和/或方框图中的每一流程和/或方框、以及流程图和/或方框图中 的流程和/或方框的结合。可提供这些计算机程序指令到通用计算机、专用计算机、嵌入式处理机或其他可编程数据处理设备的微控制器以产生一个机器，使得通过计算机或其他可编程数据处理设备的微控制器执行的指令产生用于实现在流程图一个流程或多个流程和/或方框图一个方框或多个方框中指定的功能的装置。
这些计算机程序指令也可存储在能引导计算机或其他可编程数据处理设备以特定方式工作的计算机可读存储器中，使得存储在该计算机可读存储器中的指令产生包括指令装置的制造品，该指令装置实现在流程图一个流程或多个流程和/或方框图一个方框或多个方框中指定的功能。
这些计算机程序指令也可装载到计算机或其他可编程数据处理设备上，使得在计算机或其他可编程设备上执行一系列操作步骤以产生计算机实现的处理，从而在计算机或其他可编程设备上执行的指令提供用于实现在流程图一个流程或多个流程和/或方框图一个方框或多个方框中指定的功能的步骤。
显然，上述实施例仅仅是为清楚地说明所作的举例，而并非对实施方式的限定。对于所属领域的普通技术人员来说，在上述说明的基础上还可以做出其它不同形式的变化或变动。这里无需也无法对所有的实施方式予以穷举。而由此所引伸出的显而易见的变化或变动仍处于本发明创造的保护范围之中。

Claims (10)

  1. 一种具有多频率模式的植入式神经刺激设备，其特征在于，包括：
    控制电路，用于确定频率模式，所述频率模式包括独立频率模式和相同频率模式，在所述独立频率模式下提供多个不同的脉冲频率、在所述相同频率模式下提供唯一的脉冲频率；
    信号输出电路，用于在所述独立频率模式下根据所述多个不同的脉冲频率输出多组脉冲信号，其中不同组的脉冲信号的脉冲频率不相同，在所述相同频率模式下根据所述唯一的脉冲频率输出多组脉冲信号，其中各组脉冲信号的脉冲频率相同。
  2. 根据权利要求1所述的植入式神经刺激设备，其特征在于，所述控制电路包括：
    多个频率寄存器，分别用于存储不同的脉冲频率；
    多个时序逻辑控制电路，分别用于根据不同的所述频率寄存器提供脉冲频率。
  3. 根据权利要求2所述的植入式神经刺激设备，其特征在于，信号输出电路包括：
    多个刺激信号输出模块，分别根据不同的所述时序逻辑控制电路提供的脉冲频率通过相应的电极输出多组刺激信号。
  4. 根据权利要求2所述的植入式神经刺激设备，其特征在于，所述控制电路在所述相同频率模式下选定一个时序逻辑控制电路，以及选定一个频率寄存器；选定的时序逻辑控制电路根据选定的频率寄存器提供唯一的脉冲频率。
  5. 根据权利要求4所述的植入式神经刺激设备，其特征在于，信号输出电路包括：
    多个刺激信号输出模块，根据选定的时序逻辑控制电路提供的唯一的脉冲频率通过相应的电极输出多组刺激信号。
  6. 根据权利要求1所述的植入式神经刺激设备，其特征在于，所述控制电路还用于提供脉冲参数，在所述独立频率模式下提供多组脉冲参数；
    所述信号输出电路根据所述多组脉冲参数设置各组脉冲信号中的各个脉冲信号。
  7. 根据权利要求6所述的植入式神经刺激设备，其特征在于，所述控制电路包括：
    多个脉冲参数寄存器，分别用于存储所述多组脉冲信号的脉冲参数；
    多个时序逻辑控制电路，分别用于根据不同的脉冲参数寄存器设置各组脉冲信号中的各个脉冲信号。
  8. 根据权利要求6所述的植入式神经刺激设备，其特征在于，所述控制电路在所述相同频率模式下提供多组脉冲参数；
    所述信号输出电路根据所述多组脉冲参数设置各组脉冲信号中的各个脉冲信号。
  9. 根据权利要求8所述的植入式神经刺激设备，其特征在于，所述控制电路包括：
    多个脉冲参数寄存器，分别用于存储所述多组脉冲信号的脉冲参数；
    多个时序逻辑控制电路，在所述相同频率模式下，选定一个时序逻辑控制电路，选定的时序逻辑控制电路用于根据不同的脉冲参数寄存器设置 各组脉冲信号中的各个脉冲信号。
  10. 根据权利要求1-9中任一项所述的植入式神经刺激设备，其特征在于，在所述独立频率模式下，不同组的脉冲信号的输出时间不相同。
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN121102719A (zh) * 2025-11-14 2025-12-12 上海玄宇医疗器械有限公司 一种基于多通道电极选择性刺激系统、方法及可存储介质

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109481844B (zh) * 2018-12-27 2021-06-11 清华大学 具有多频率模式的植入式神经刺激设备
CN110141784B (zh) * 2019-05-28 2024-12-13 清华大学 植入式医疗设备及其脉冲刺激方法
CN110975141A (zh) * 2019-09-16 2020-04-10 清华大学 植入式神经刺激设备
CN110772715A (zh) * 2019-09-16 2020-02-11 清华大学 植入式神经刺激设备及其脉冲频率设置方法
CN111420276A (zh) * 2020-03-23 2020-07-17 清华大学 具有变频功能的植入式神经刺激设备及系统
CN113426008B (zh) * 2021-05-07 2025-02-25 未来穿戴技术有限公司 按摩控制方法及按摩设备、计算机可读存储介质

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107050644A (zh) * 2017-01-13 2017-08-18 北京品驰医疗设备有限公司 一种刺激频率变化的骶神经刺激装置
CN107185109A (zh) * 2017-05-17 2017-09-22 苏州景昱医疗器械有限公司 自适应控制模块及具有其的植入式神经刺激系统
CN107864632A (zh) * 2015-04-22 2018-03-30 波士顿科学神经调制公司 用于对神经调节装置进行编程的系统
WO2018144521A1 (en) * 2017-02-01 2018-08-09 Boston Scientific Neuromodulation Corporation Stimulation field templates to be applied across patient populations
CN108744270A (zh) * 2017-03-28 2018-11-06 洛桑联邦理工学院 用于中枢神经刺激和外周神经刺激的神经刺激系统
CN109481844A (zh) * 2018-12-27 2019-03-19 清华大学 具有多频率模式的植入式神经刺激设备

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102457252B (zh) * 2010-10-25 2015-01-21 苏州景昱医疗器械有限公司 双通道脉冲发生器及植入式电刺激系统
US9526899B2 (en) * 2013-03-15 2016-12-27 Globus Medical, Inc. Implantable pulse generator that generates spinal cord stimulation signals for a human body
EP2968932B1 (en) * 2013-03-15 2017-10-18 Boston Scientific Neuromodulation Corporation Neuromodulation system for providing multiple modulation patterns in a single channel
EP2986339A4 (en) * 2013-04-19 2016-12-21 Oculeve Inc Nasal stimulation devices and methods
CN203507317U (zh) * 2013-10-25 2014-04-02 中国医学科学院生物医学工程研究所 三维超声影像导航下的膀胱自主控制系统
CN104888346B (zh) * 2014-12-21 2020-10-13 徐志强 对昏迷大脑进行神经刺激的方法及装置
CN106390281A (zh) * 2016-02-03 2017-02-15 泰安市康宇医疗器械有限公司 督脉治疗仪
CN207071165U (zh) * 2016-10-08 2018-03-06 关沛棠 一种智能复合波形经颅电刺激系统

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107864632A (zh) * 2015-04-22 2018-03-30 波士顿科学神经调制公司 用于对神经调节装置进行编程的系统
CN107050644A (zh) * 2017-01-13 2017-08-18 北京品驰医疗设备有限公司 一种刺激频率变化的骶神经刺激装置
WO2018144521A1 (en) * 2017-02-01 2018-08-09 Boston Scientific Neuromodulation Corporation Stimulation field templates to be applied across patient populations
CN108744270A (zh) * 2017-03-28 2018-11-06 洛桑联邦理工学院 用于中枢神经刺激和外周神经刺激的神经刺激系统
CN107185109A (zh) * 2017-05-17 2017-09-22 苏州景昱医疗器械有限公司 自适应控制模块及具有其的植入式神经刺激系统
CN109481844A (zh) * 2018-12-27 2019-03-19 清华大学 具有多频率模式的植入式神经刺激设备

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN121102719A (zh) * 2025-11-14 2025-12-12 上海玄宇医疗器械有限公司 一种基于多通道电极选择性刺激系统、方法及可存储介质

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