WO2020107607A1 - 一种非人灵长类动物外置监测器固定装置和外置监测系统 - Google Patents

一种非人灵长类动物外置监测器固定装置和外置监测系统 Download PDF

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Publication number
WO2020107607A1
WO2020107607A1 PCT/CN2018/124117 CN2018124117W WO2020107607A1 WO 2020107607 A1 WO2020107607 A1 WO 2020107607A1 CN 2018124117 W CN2018124117 W CN 2018124117W WO 2020107607 A1 WO2020107607 A1 WO 2020107607A1
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Prior art keywords
glove
external monitor
external
lock
monitor
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PCT/CN2018/124117
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English (en)
French (fr)
Inventor
贾香连
王立平
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Shenzhen Institute of Advanced Technology of CAS
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Shenzhen Institute of Advanced Technology of CAS
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Publication of WO2020107607A1 publication Critical patent/WO2020107607A1/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802—Sensor mounted on worn items
    • A61B5/6804—Garments; Clothes
    • A61B5/6806—Gloves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00—Evaluating a particular growth phase or type of persons or animals
    • A61B2503/40—Animals

Definitions

  • the invention belongs to the field of life science and technology, and particularly relates to a non-human primate external monitor fixing device and an external monitoring system.
  • the method of implants for real-time monitoring of rodent blood glucose is to embed the blood glucose implant in the rodent artery to achieve continuous 24-hour blood glucose monitoring.
  • the blood glucose data is output to the computer terminal through wireless transmission technology.
  • products for real-time monitoring of blood glucose are emerging in endlessly.
  • the present invention aims to solve at least one of the above technical problems, and provides a non-human primate external monitor fixing device and an external monitoring system, which can realize non-invasive measurement and have good safety and reliability.
  • a non-human primate external monitor fixing device including a glove capable of placing an external monitor and a lock ring for fixing the glove and having an inner diameter adjustable, the glove having an opening , The lock ring is connected to the opening of the glove.
  • the gloves are steel wire gloves.
  • the glove has a bag for accommodating an external monitor at the back of the hand.
  • the steel wire glove is welded to the locking ring, or the steel wire glove is provided with a connecting ear, and the locking ring passes through the connecting ear.
  • the lock ring is in the shape of handcuffs, and includes a relatively movable first lock body and a second lock body, which are rotatably connected between the first lock body and the second lock body and form a closed loop with an adjustable inner diameter structure.
  • the invention also provides an external monitoring system for non-human primates, including an external monitor, a glove capable of placing the external monitor, and a lock ring for fixing the glove and having an adjustable inner diameter, the glove having an opening
  • the lock ring is connected to the opening of the glove
  • the external monitor has a wireless transmission module
  • the non-human primate external monitoring system further includes a receiver that cooperates with the external monitor terminal.
  • the external monitor is a blood glucose monitor
  • the receiving terminal is a computer
  • the gloves are steel wire gloves.
  • the steel wire glove is welded to the locking ring, or the steel wire glove is provided with a connecting ear, and the locking ring passes through the connecting ear.
  • the lock ring is in the shape of handcuffs, and includes a relatively movable first lock body and a second lock body, which are rotatably connected between the first lock body and the second lock body and form a closed loop with an adjustable inner diameter structure.
  • the invention provides a non-human primate external monitor fixing device and an external monitoring system, which can realize non-invasive measurement. Compared with the implant technology, there is no need to embed the implant in surgery It is safe and convenient in monkey blood vessels. Secondly, compared with the real-time dynamic monitoring of blood sugar in humans, it can solve the problem of the physiological monitor falling off due to the active nature of monkeys, and can easily monitor the relevant physiological data of non-human primates (except marmosets). (Eg blood glucose data).
  • FIG. 1 is a schematic plan view of a glove in a non-human primate external monitor fixing device provided by an embodiment of the present invention
  • FIG. 2 is a schematic plan view of a glove and an external monitor in a fixing device for an external monitor of a non-human primate provided by an embodiment of the present invention
  • FIG. 3 is a schematic diagram of a locking ring in a fixing device for an external monitor of non-human primates provided by an embodiment of the present invention.
  • setting and “connection” should be understood in a broad sense, for example, it can be directly set and connected, or indirectly set and connected through a centering component or centering structure.
  • a non-human primate external monitor fixing device provided by an embodiment of the present invention can be used for physiological monitoring of non-human primates.
  • the non-human primate Long animals take monkeys as an example.
  • the above non-human primate external monitor fixing device includes a glove (the glove may be a cut-resistant glove, such as a steel wire glove 10) for placing the external monitor 20, and a lock ring for fixing the glove and having an inner diameter adjustable and locked 30.
  • the glove has an opening 11, and the lock ring 30 is connected to the opening 11 of the glove.
  • the glove can be worn on the monkey's hand.
  • the opening 11 of the glove corresponds to the monkey's wrist.
  • the lock ring 30 is connected to the glove and can be locked onto the monkey's wrist to prevent the glove from falling off the monkey's hand.
  • An external monitor 20 Put in the glove and make contact with the body surface of the monkey, and then you can monitor the corresponding physiological data, such as measuring the blood sugar of the monkey. In this way, non-invasive measurement can be achieved.
  • implant technology there is no need to embed the implant in the blood vessel of the monkey, which is safe and convenient.
  • it compared with the real-time dynamic monitoring of blood sugar in humans, it can solve the problem of the physiological monitor falling off due to the active nature of monkeys, and can easily monitor the relevant physiological data of non-human primates (except marmosets). (Eg blood glucose data, body temperature data, pulse data).
  • the glove may be a cut-resistant glove and has a certain elasticity.
  • the above-mentioned steel wire glove 10 may be formed by welding and braiding stainless steel rings and stainless steel rings independently. It has good flexibility, good cut resistance and wear resistance. To prevent damage due to scratching, the structure is reliable and does not affect the normal activities of the monkey. The monkey can eat and climb as usual.
  • the size of the steel wire glove 10 can be customized according to the size of the monkey hand, and the size can just fit the shape of the monkey hand, and can fix the external monitor 20 well.
  • the inner side of the steel wire glove 10 may be provided with an inner liner, such as a cloth inner liner or a sponge inner liner, which is breathable and has a certain protective effect.
  • the outer side of the steel wire glove 10 may be provided with a protective layer, such as a cloth protective layer.
  • the steel wire glove 10 may have a five-finger structure, and may be a finger-leakage type or a finger-leakage type.
  • Figures 1 and 2 show the finger-less type.
  • the steel wire glove itself has a certain elasticity, and can well adapt to the shape of the monkey's hand, and the external monitor is attached to the surface of the monkey's body.
  • the glove has a bag body for accommodating the external monitor 20 at the back of the hand, that is, the glove can be specially prepared with a bag body connected to the internal space of the glove. Table contact, can effectively fix the external monitor 20, the monitoring effect is good.
  • the size and shape of the bag body can match the size and shape of the external monitor 20.
  • a zipper can be sewn on the surface or side of the bag, so that it is easy to maintain and take out the external monitor 20 from the bag through the zipper.
  • the zipper head can be fixed by a metal buckle or lock (padlock) to prevent the monkey from unzipping the zipper .
  • the external monitor 20 may be provided with a display screen, which can be used to display relevant physiological data (such as blood glucose data, body temperature data, pulse data) information, temperature information, battery power information, wireless signal strength information, etc., the surface of the bag body Or, a transparent plastic film may be sewn on the side.
  • the transparent plastic film corresponds to the display screen of the external monitor 20 for easy observation.
  • gloves can be impregnated or coated with a non-toxic bitter agent, such as bitter gourd juice, etc., to avoid monkey bites.
  • the wire glove 10 can be welded to the lock ring 30, or the wire glove 10 is provided with a connecting ear, and the lock ring 30 passes through the connecting ear, which can effectively fix the wire glove 10 on the monkey's hand.
  • the lock ring 30 may be in the shape of handcuffs, including a relatively movable first lock body 31 and a second lock body 32, the first lock body 31 and the second lock body 32 may be arc-shaped and connected by rotation through a pin 33, The first lock body 31 and the second lock body 32 are rotationally connected and enclosed to form a closed structure with an adjustable inner diameter.
  • the first lock body 31 is provided with a lock tooth portion
  • the second lock body 32 is provided with a lock slot into which the lock tooth portion rotates and slides, and a lock pin for preventing the lock tooth portion from exiting the lock groove is provided in the lock groove.
  • the second lock body 32 is also provided with a lock cylinder for controlling the lock pin.
  • annular cloth cover may be sleeved on the outer side of the lock ring 30, and a sponge layer may be filled in the ring cloth cover.
  • the external monitor 20 has a non-invasive detection module, a wireless transmission module or a wireless transceiver module, and a battery built-in.
  • the external monitor 20 may be a non-invasive blood glucose monitor, which has a wireless sending function, and can send blood glucose data to a designated receiving device through wireless transmission, such as a computer, a smart phone, a tablet computer, and the like.
  • An embodiment of the present invention also provides an external monitoring system for non-human primates, which can use the above-mentioned external monitor fixing device, specifically, includes an external monitor 20 and a glove for placing the external monitor 20 And a lock ring 30 for fixing the glove and having an adjustable inner diameter, the glove has an opening portion 11, the lock ring 30 is connected to the opening of the glove, the external monitor 20 has a wireless transmission module, and an external monitoring system for non-human primates It also includes a receiving terminal that cooperates with the external monitor 20.
  • the glove can be worn on the monkey's hand.
  • the opening 11 of the glove corresponds to the monkey's wrist.
  • the lock ring 30 is connected to the glove and can be placed on the monkey's wrist to prevent the glove from falling off the monkey's hand.
  • the external monitor 20 is a blood glucose monitor with a wireless communication module
  • the receiving terminal is a computer.
  • the external monitor 20 may also have a wireless communication module.
  • the wireless communication module may be a 3G or 4G communication module or a Bluetooth module or a WIFI module or a ZIGBEE module.
  • the glove may be a cut-resistant glove, such as a steel wire glove 10 (soft steel wire glove 10), which may be welded and knitted by a stainless steel ring and a stainless steel ring independently. It has good flexibility, good cut resistance and wear resistance. To prevent damage due to scratching, the structure is reliable and does not affect the normal activities of the monkey.
  • the monkey can eat and climb as usual.
  • the size of the steel wire glove 10 is customized according to the size of the monkey hand, and the size can just fit the shape of the monkey hand. It can be a five-finger steel wire glove 10, which can fix the external monitor 20 well.
  • the inner side of the steel wire glove 10 may be provided with an inner liner, such as a cloth inner liner or a sponge inner liner, which is breathable and has a certain protective effect.
  • the outer side of the steel wire glove 10 may be provided with a protective layer, such as a cloth protective layer.
  • the glove has a bag body for accommodating the external monitor 20 at the back of the hand, that is, the glove can be specially designed to have a bag body connected to the inner space of the glove, and the bag body can have a convex hull shape relative to the back of the glove hand.
  • the external monitor 20 can be placed in the body of the bag and contacted with the body surface of the monkey, which can effectively fix the external monitor 20 and has a good monitoring effect.
  • the bag body can be located at a suitable position such as the back of the hand or the finger.
  • the size and shape of the bag body can match the size and shape of the external monitor 20.
  • the bag body may not be provided.
  • the steel wire glove 10 is welded to the locking ring 30, or the steel wire glove 10 is provided with a connecting ear, and the locking ring 30 passes through the connecting ear, that is, the opening of the glove is reserved for the structure through which the locking ring 30 passes through an integral braid
  • the wire glove 10 can be effectively fixed on the monkey's hand.
  • the handcuff structure (lock ring 30) is welded to the steel wire glove 10 to protect the physiological monitor from being damaged by the monkey's active nature (external monitor 20), and the physiological monitor can Stable and reliable contact with the body surface of the measured object, the measurement results are more accurate and reliable.
  • the edge of the opening 11 on the wire glove 10 can be welded to the wire glove 10 after turning over the lock ring 30, and the operation position can be left at the locking position of the lock ring 30. Fixation of the lock ring 30.
  • the lock ring 30 may be in the shape of a single handcuff.
  • the lock ring 30 includes a first lock body 31 and a second lock body 32 that are relatively movable.
  • the first lock body 31 and the second lock body 32 are rotationally connected and enclosed Form a closed structure with adjustable inner diameter.
  • the first lock body 31 is provided with a lock tooth portion
  • the second lock body 32 is provided with a lock slot into which the lock tooth portion rotates and slides.
  • a lock pin for preventing the lock tooth portion from exiting the lock groove is provided in the lock groove.
  • the second lock body 32 is also provided with a lock cylinder for controlling the lock pin. Through the special key, the lock core can be rotated and the lock pin can release the restriction on the lock tooth portion.
  • the lock tooth portion of the first lock body 31 can exit the lock slot, the lock ring 30 can be opened, and the wire glove 10 can be removed from the monkey hand.
  • the first lock body 31 and the second lock body 32 may also use electronic locks, such as electronic locks unlocked by Bluetooth wireless signals, which is convenient to operate.
  • the lock ring 30 can also be implemented with a strap or the like.
  • the non-human primate external monitor fixing device and external monitoring system provided by the embodiments of the present invention can realize non-invasive measurement. Compared with the implant technology, there is no need to bury the implant by surgery It is safe and convenient to insert into the blood vessel of monkey. Secondly, compared with the real-time dynamic monitoring of blood sugar in humans, it can solve the problem of the physiological monitor falling off due to the active nature of monkeys, and can easily monitor the relevant physiological data of non-human primates (except marmosets). (Eg blood glucose data).

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Abstract

一种非人灵长类动物外置监测器（20）固定装置和外置监测系统。该非人灵长类动物外置监测器（20）固定装置包括可放置外置监测器（20）的手套（10）和用于固定手套（10）且内径可调的锁环（30），手套（10）具有开口部（11），锁环（30）连接于手套（10）的开口（11）处。该非人灵长类动物外置监测系统包括具有无限发射模块的外置监测器（20）、外置监测器（20）固定装置以及与外置监测器（20）配合的接收终端。该外置监测系统可实现无创伤测量，方便地监测非人灵长类动物的相关生理数据。

Description

一种非人灵长类动物外置监测器固定装置和外置监测系统 技术领域
本发明属于生命科学技术领域，尤其涉及一种非人灵长类动物外置监测器固定装置和外置监测系统。
 背景技术
动物的生理指标血糖等，在动物的生命活动中起到至关重要的作用。在人生命活动中，血糖的紊乱出现低血糖或者糖尿病。低血糖会导致昏迷，大脑长时间的低血糖也会导致脑死亡，而糖尿病是目前世界流行病的高发病。糖尿病和低血糖的发病机理是目前研究的热点话题。由于啮齿类动物和人生理机能在进化上差别极大，造成啮齿类动物研究成果不能直接运用到人上。非人灵长类动物生理机能和人类最接近，研究机理能直接类比到人类中。
啮齿类动物血糖实时监测用植入子的方法，将血糖植入子埋置在啮齿类动物动脉，实现24小时连续监测血糖，血糖数据通过无线传播技术，输出在电脑终端。人类中，血糖实时监测的产品层出不穷。
然而，非人灵长类动物体型大，手术难度大，活动度强，啮齿类动物上的血糖植入子不能运用到猴子中。而用在人中的血糖监测器不容易在猴子中固定。
目前，还没有可以方便监测非人灵长类动物（除狨猴外）血糖的设备和方法。
 技术问题
本发明旨在至少解决上述技术问题之一，提供了一种非人灵长类动物外置监测器固定装置和外置监测系统，其可以实现无创伤测量，安全可靠性佳。
 技术解决方案
本发明的技术方案是：一种非人灵长类动物外置监测器固定装置，包括可放置外置监测器的手套和用于固定手套且内径可调的锁环，所述手套具有开口部，所述锁环连接于所述手套的开口处。
可选地，所述手套为钢丝手套。
可选地，所述手套对应手背处具有用于容纳外置监测器的袋体。
可选地，所述钢丝手套焊接于所述锁环，或者，所述钢丝手套设置有连接耳，所述锁环穿过于所述连接耳。
可选地，所述锁环呈手铐状，包括可相对活动的第一锁体和第二锁体，所述第一锁体和第二锁体之间转动连接且合围形成内径可调的闭合结构。
本发明还提供了一种非人灵长类动物外置监测系统，包括外置监测器、可放置外置监测器的手套和用于固定手套且内径可调的锁环，所述手套具有开口部，所述锁环连接于所述手套的开口处，所述外置监测器具有无线发射模块，所述非人灵长类动物外置监测系统还包括与所述外置监测器配合的接收终端。
可选地，所述外置监测器为血糖监测器，所述接收终端为电脑。
可选地，所述手套为钢丝手套。
可选地，所述钢丝手套焊接于所述锁环，或者，所述钢丝手套设置有连接耳，所述锁环穿过于所述连接耳。
可选地，所述锁环呈手铐状，包括可相对活动的第一锁体和第二锁体，所述第一锁体和第二锁体之间转动连接且合围形成内径可调的闭合结构。
 有益效果
本发明所提供的一种非人灵长类动物外置监测器固定装置和外置监测系统，可以实现无创伤测量，与植入子技术相比，不需要用手术将植入子埋置入猴子血管中，安全便捷。其次，与人类的实时动态监测血糖相比，能很好解决由于猴子好动天性引起的生理监测仪脱落的情况，可以方便地监测非人灵长类动物（除狨猴外）的相关生理数据（例如血糖数据）。
 附图说明
为了更清楚地说明本发明实施例中的技术方案，下面将对实施例中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。
图1是本发明实施例提供的一种非人灵长类动物外置监测器固定装置中手套的平面示意图；
图2是本发明实施例提供的一种非人灵长类动物外置监测器固定装置中手套和外置监测器的平面示意图；
图3是本发明实施例提供的一种非人灵长类动物外置监测器固定装置中锁环的示意图。
 本发明的实施方式
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合附图及实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。
需要说明的是，术语“设置”、“连接”应做广义理解，例如，可以是直接设置、连接，也可以通过居中元部件、居中结构间接设置、连接。
另外，本发明实施例中若有“纵向”、“横向”、“长度”、“宽度”、“厚度”、“上”、“下”、“前”、“后”、“左”、“右”、“竖直”、“水平”、“顶”、“底”“内”、“外”等指示的方位或位置关系的用语，其为基于附图所示的方位或位置关系或常规放置状态或使用状态，其仅是为了便于描述本发明和简化描述，而不是指示或暗示所指的结构、特征、装置或元件必须具有特定的方位或位置关系、也不是必须以特定的方位构造和操作，因此不能理解为对本发明的限制。在本发明的描述中，除非另有说明，“多个”的含义是两个或两个以上。
在具体实施方式中所描述的各个具体技术特征和各实施例，在不矛盾的情况下，可以通过任何合适的方式进行组合，例如通过不同的具体技术特征/实施例的组合可以形成不同的实施方式，为了避免不必要的重复，本发明中各个具体技术特征/实施例的各种可能的组合方式不再另行说明。
如图1至图3所示，本发明实施例提供的一种非人灵长类动物外置监测器固定装置，可用于非人灵长类动物的生理监测，本实施例中，非人灵长类动物以猴子为例。上述非人灵长类动物外置监测器固定装置包括可放置外置监测器20的手套（手套可为防割手套，例如钢丝手套10）和用于固定手套且内径可调并锁定的锁环30，手套具有开口部11，锁环30连接于手套的开口部11处。手套可以穿戴于猴子的手部，手套的开口部11对应于猴子的腕部，锁环30连接于手套且可锁套于猴子的腕部，从而防止手套从猴子手部脱落，外置监测器20置于手套内且与猴子的体表接触，进而可以进行相应的生理数据监测，例如测量猴子的血糖等。这样，可以实现无创伤测量，与植入子技术相比，不需要用手术将植入子埋置入猴子血管中，安全便捷。其次，与人类的实时动态监测血糖相比，能很好解决由于猴子好动天性引起的生理监测仪脱落的情况，可以方便地监测非人灵长类动物（除狨猴外）的相关生理数据（例如血糖数据、体温数据、脉搏数据） 。
具体地，手套可为防割手套且具有一定的弹性，例如上述的钢丝手套10可由不锈钢钢环和不锈钢圈独立焊接穿编而成，其柔韧性好、防割性能和耐磨性能佳，可防止因抓扯而损坏，结构可靠且不影响猴子的正常活动，猴子可以照常进食、攀爬等。钢丝手套10的大小可按猴子手大小定制，大小可刚好适合猴子手形，能够很好地固定外置监测器20。具体应用中，钢丝手套10的内侧可以设置有内衬，例如布质内衬或海绵内衬，其透气且具有一定的防护作用。钢丝手套10的外侧可以设置防护层，例如布质防护层。具体应用中，钢丝手套10可为五指结构，可为漏指式或不漏指式。图1、2中所示为不漏指式。钢丝手套本身具有一定的弹性，能很好地适应猴子的手形，且使外置监测器贴于猴子体表。
具体地，手套对应手背处具有用于容纳外置监测器20的袋体，即手套可以特制一个连通于手套内部空间的一个袋体，外置监测器20可以放置于袋体内后与猴子的体表接触，可以有效地固定外置监测器20，监测效果佳。袋体的大小、形状可与外置监测器20的大小形状匹配。袋体的表面或侧面处可以缝置有拉链，这样，易于从袋体处通过拉链维护、取放外置监测器20，拉链头可由金属扣或锁具（挂锁）固定，防止猴子自行拉开拉链。外置监测器20可以设置有显示屏，显示屏可以用于显示相关生理数据（例如血糖数据、体温数据、脉搏数据）信息、温度信息、电池电量信息、无线信号强度信息等，袋体的表面或侧面处可以缝制有透明塑胶膜，透明塑胶膜对应于外置监测器20的显示屏处，以便于观察。具体应用中，手套可浸有或涂有无毒的苦味剂，例如苦瓜汁等，以避免猴子啃咬。
具体地，钢丝手套10可焊接于锁环30，或者，钢丝手套10设置有连接耳，锁环30穿过于连接耳，可以有效地将钢丝手套10固定于猴子手上。
具体地，锁环30可呈手铐状，包括可相对活动的第一锁体31和第二锁体32，第一锁体31和第二锁体32可呈弧状且通过销轴33转动连接，第一锁体31和第二锁体32之间转动连接且合围形成内径可调的闭合结构。第一锁体31设置有锁齿部，第二锁体32设置有供锁齿部转动滑入的锁槽，锁槽内设置有用于防止锁齿部退出锁槽的锁销。第二锁体32还设置有用于控制锁销的锁芯。通过特制钥匙可以转动锁芯而锁销解除对锁齿部的限制，锁环30可以打开，钢丝手套10可以从猴子手上取下。
具体应用中，锁环30外侧可以套有环形布套，环形布套内可以填充有海绵层。
外置监测器20内置有无创检测模块、无线发送模块或无线收发模块和电池。具体地，外置监测器20可为无创式血糖监测器，其具有无线发送功能，可以将血糖数据通过无线传输的方式发送给指定的接收装置，例如电脑、智能手机、平板电脑等。
本发明实施例还提供了一种非人灵长类动物外置监测系统，可使用上述的外置监测器固定装置，具体地，包括外置监测器20、可放置外置监测器20的手套和用于固定手套且内径可调的锁环30，手套具有开口部11，锁环30连接于手套的开口处，外置监测器20具有无线发射模块，非人灵长类动物外置监测系统还包括与外置监测器20配合的接收终端。手套可以穿戴于猴子的手部，手套的开口部11对应于猴子的腕部，锁环30连接于手套且可套于猴子的腕部，从而防止手套从猴子手部脱落，外置监测器20置于手套内且与猴子的体表接触，进而可以进行相应的生理数据监测，例如测量猴子的血糖等。这样，可以实现无创伤测量，与植入子技术相比，不需要用手术将植入子埋置入猴子血管中，安全便捷。其次，与人类的实时动态监测血糖相比，能很好解决由于猴子好动天性引起的生理监测仪脱落的情况，可以方便地监测非人灵长类动物（除狨猴外）的相关生理数据（例如血糖数据） 。
具体地，外置监测器20为具有无线通讯模块的血糖监测器，接收终端为电脑。外置监测器20除了内置有无创（血糖）测量模块、电池外，还可以内置有无线通讯模块，无线通讯模块可为3G或4G通讯模块或蓝牙模块或WIFI模块或ZIGBEE模块等。
具体地，手套可为防割手套，例如钢丝手套10（软钢丝手套10），可由不锈钢钢环和不锈钢圈独立焊接穿编而成，其柔韧性好、防割性能和耐磨性能佳，可防止因抓扯而损坏，结构可靠且不影响猴子的正常活动，猴子可以照常进食、攀爬等。钢丝手套10的大小按猴子手大小定制，大小可刚好适合猴子手形，可为五指式钢丝手套10，能够很好地固定外置监测器20。具体应用中，钢丝手套10的内侧可以设置有内衬，例如布质内衬或海绵内衬，其透气且具有一定的防护作用。钢丝手套10的外侧可以设置防护层，例如布质防护层。
具体地，手套对应手背处具有用于容纳外置监测器20的袋体，即手套可以特制一个连通于手套内部空间的一个袋体，袋体可呈相对于手套手背处的一个凸包状。外置监测器20可以放置于袋体内并与猴子的体表接触，可以有效地固定外置监测器20，监测效果佳。袋体可以位于手背处或手指处等合适位置。袋体的大小、形状可与外置监测器20的大小形状匹配。袋体处可以不设置有钢丝，以利于外置监测器20无线信号的传输。当然，具体应用中，也可以不设置袋体。
具体地，钢丝手套10焊接于锁环30，或者，钢丝手套10设置有连接耳，锁环30穿过于连接耳，即手套的开口处通过一体编织预留有用于供锁环30穿过的结构，也可以有效地将钢丝手套10固定于猴子手上。本实施例中，手铐结构（锁环30）焊接在钢丝手套10上，保护生理监测仪，不被猴子由于好动的天性而损坏生理监测仪（外置监测器20），且生理监测仪可以稳定可靠地与被测对象的体表接触，测量结果更准确、可靠。当然，也可以将钢丝手套10上开口部11的边缘翻过锁环30后焊接于钢丝手套10上，在锁环30的锁闭处留出操作位置即可，也可以实现将钢丝手套10与锁环30的固定。
具体地，锁环30可呈单个的手铐状，锁环30包括可相对活动的第一锁体31和第二锁体32，第一锁体31和第二锁体32之间转动连接且合围形成内径可调的闭合结构。第一锁体31设置有锁齿部，第二锁体32设置有供锁齿部转动滑入的锁槽，锁槽内设置有用于防止锁齿部退出锁槽的锁销，锁销可以卡于锁齿部的齿形处。第二锁体32还设置有用于控制锁销的锁芯。通过特制钥匙可以转动锁芯而锁销解除对锁齿部的限制，第一锁体31的锁齿部可以退出锁槽，锁环30可以打开，钢丝手套10可以从猴子手上取下。或者，第一锁体31和第二锁体32也可以采用电子锁，例如通过蓝牙无线信号解锁的电子锁，操作便利。
具体应用中，锁环30也可以采用绑带等装置实现。
当然，除了可以用于研究动物的血糖代谢，还可以用其他需要将生理监测仪固定在猴子身上进行生理信号采集。
本发明实施例所提供的一种非人灵长类动物外置监测器固定装置和外置监测系统，可以实现无创伤测量，与植入子技术相比，不需要用手术将植入子埋置入猴子血管中，安全便捷。其次，与人类的实时动态监测血糖相比，能很好解决由于猴子好动天性引起的生理监测仪脱落的情况，可以方便地监测非人灵长类动物（除狨猴外）的相关生理数据（例如血糖数据）。
以上仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内所作的任何修改、等同替换或改进等，均应包含在本发明的保护范围之内。

Claims (10)

  1. 一种非人灵长类动物外置监测器固定装置，其特征在于，包括可放置外置监测器的手套和用于固定手套且内径可调的锁环，所述手套具有开口部，所述锁环连接于所述手套的开口处。
  2. 如权利要求1所述的一种非人灵长类动物外置监测器固定装置，其特征在于，所述手套为钢丝手套。
  3. 如权利要求1所述的一种非人灵长类动物外置监测器固定装置，其特征在于，所述手套对应手背处具有用于容纳外置监测器的袋体。
  4.  如权利要求2所述的一种非人灵长类动物外置监测器固定装置，其特征在于，所述钢丝手套焊接于所述锁环，或者，所述钢丝手套设置有连接耳，所述锁环穿过于所述连接耳。
  5. 如权利要求1至4中任一项所述的一种非人灵长类动物外置监测器固定装置，其特征在于，所述锁环呈手铐状，包括可相对活动的第一锁体和第二锁体，所述第一锁体和第二锁体之间转动连接且合围形成内径可调的闭合结构。
  6. 一种非人灵长类动物外置监测系统，其特征在于，包括外置监测器、可放置外置监测器的手套和用于固定手套且内径可调的锁环，所述手套具有开口部，所述锁环连接于所述手套的开口处，所述外置监测器具有无线发射模块，所述非人灵长类动物外置监测系统还包括与所述外置监测器配合的接收终端。
  7. 如权利要求6所述的一种非人灵长类动物外置监测系统，其特征在于，所述外置监测器为血糖监测器，所述接收终端为电脑。
  8. 如权利要求6或7所述的一种非人灵长类动物外置监测系统，其特征在于，所述手套为钢丝手套。
  9. 如权利要求8所述的一种非人灵长类动物外置监测系统，其特征在于，所述钢丝手套焊接于所述锁环，或者，所述钢丝手套设置有连接耳，所述锁环穿过于所述连接耳。
  10. 如权利要求6或7所述的一种非人灵长类动物外置监测系统，其特征在于，所述锁环呈手铐状，包括可相对活动的第一锁体和第二锁体，所述第一锁体和第二锁体之间转动连接且合围形成内径可调的闭合结构。
PCT/CN2018/124117 2018-11-30 2018-12-27 一种非人灵长类动物外置监测器固定装置和外置监测系统 Ceased WO2020107607A1 (zh)

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