WO2020037189A1 - Formulations of ag10 - Google Patents
Formulations of ag10 Download PDFInfo
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- WO2020037189A1 WO2020037189A1 PCT/US2019/046789 US2019046789W WO2020037189A1 WO 2020037189 A1 WO2020037189 A1 WO 2020037189A1 US 2019046789 W US2019046789 W US 2019046789W WO 2020037189 A1 WO2020037189 A1 WO 2020037189A1
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- tablet formulation
- tablet
- weight
- pharmaceutically acceptable
- acceptable salt
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000009490 roller compaction Methods 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 238000004885 tandem mass spectrometry Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229940126622 therapeutic monoclonal antibody Drugs 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 238000011870 unpaired t-test Methods 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020217007760A KR20210046708A (en) | 2018-08-17 | 2019-08-16 | Formulation of AG10 |
EP19849948.5A EP3836920A4 (en) | 2018-08-17 | 2019-08-16 | Formulations of ag10 |
JP2021507989A JP7469293B2 (en) | 2018-08-17 | 2019-08-16 | Preparation of AG10 |
CN201980054507.6A CN112804998A (en) | 2018-08-17 | 2019-08-16 | Formulation of AG10 |
MX2021001761A MX2021001761A (en) | 2018-08-17 | 2019-08-16 | Formulations of ag10. |
AU2019321583A AU2019321583A1 (en) | 2018-08-17 | 2019-08-16 | Formulations of AG10 |
SG11202101393PA SG11202101393PA (en) | 2018-08-17 | 2019-08-16 | Formulations of ag10 |
BR112020026493-8A BR112020026493A2 (en) | 2018-08-17 | 2019-08-16 | AG10 FORMULATIONS |
EA202190561A EA202190561A1 (en) | 2018-08-17 | 2019-08-16 | AG10 PREPARATIONS |
CA3104695A CA3104695A1 (en) | 2018-08-17 | 2019-08-16 | Formulations of ag10 |
IL280906A IL280906A (en) | 2018-08-17 | 2021-02-16 | Formulations of ag10 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862765154P | 2018-08-17 | 2018-08-17 | |
US62/765,154 | 2018-08-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2020037189A1 true WO2020037189A1 (en) | 2020-02-20 |
Family
ID=69524257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2019/046789 WO2020037189A1 (en) | 2018-08-17 | 2019-08-16 | Formulations of ag10 |
Country Status (15)
Country | Link |
---|---|
US (2) | US11260047B2 (en) |
EP (1) | EP3836920A4 (en) |
JP (1) | JP7469293B2 (en) |
KR (1) | KR20210046708A (en) |
CN (1) | CN112804998A (en) |
AU (1) | AU2019321583A1 (en) |
BR (1) | BR112020026493A2 (en) |
CA (1) | CA3104695A1 (en) |
CL (1) | CL2021000289A1 (en) |
EA (1) | EA202190561A1 (en) |
IL (1) | IL280906A (en) |
MA (1) | MA53238A (en) |
MX (1) | MX2021001761A (en) |
SG (1) | SG11202101393PA (en) |
WO (1) | WO2020037189A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023052652A1 (en) | 2021-10-01 | 2023-04-06 | Sandoz Ag | Crystalline form of acoramidis hydrochloride |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA201991921A1 (en) | 2017-02-17 | 2020-02-06 | Эйдос Терапьютикс, Инк. | METHODS FOR PRODUCING AG-10, ITS INTERMEDIATE COMPOUNDS AND THEIR SALTS |
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WO2014100227A1 (en) | 2012-12-21 | 2014-06-26 | The Board Of Trustees Of The Leland Stanford Junior University | Transthyretin stabilizers and their use for inhibiting transthyretin amyloidosis and protein-protein interactions |
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-
2019
- 2019-08-16 EA EA202190561A patent/EA202190561A1/en unknown
- 2019-08-16 CN CN201980054507.6A patent/CN112804998A/en active Pending
- 2019-08-16 WO PCT/US2019/046789 patent/WO2020037189A1/en unknown
- 2019-08-16 MA MA053238A patent/MA53238A/en unknown
- 2019-08-16 SG SG11202101393PA patent/SG11202101393PA/en unknown
- 2019-08-16 BR BR112020026493-8A patent/BR112020026493A2/en unknown
- 2019-08-16 AU AU2019321583A patent/AU2019321583A1/en active Pending
- 2019-08-16 CA CA3104695A patent/CA3104695A1/en active Pending
- 2019-08-16 EP EP19849948.5A patent/EP3836920A4/en active Pending
- 2019-08-16 US US16/542,737 patent/US11260047B2/en active Active
- 2019-08-16 KR KR1020217007760A patent/KR20210046708A/en unknown
- 2019-08-16 JP JP2021507989A patent/JP7469293B2/en active Active
- 2019-08-16 MX MX2021001761A patent/MX2021001761A/en unknown
-
2021
- 2021-02-03 CL CL2021000289A patent/CL2021000289A1/en unknown
- 2021-02-16 IL IL280906A patent/IL280906A/en unknown
-
2022
- 2022-01-18 US US17/577,479 patent/US20220313661A1/en active Pending
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US20130095181A1 (en) | 2010-04-07 | 2013-04-18 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyriodin-2-yl)benzoic acid and administration thereof |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023052652A1 (en) | 2021-10-01 | 2023-04-06 | Sandoz Ag | Crystalline form of acoramidis hydrochloride |
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US11260047B2 (en) | 2022-03-01 |
EP3836920A4 (en) | 2022-04-13 |
BR112020026493A2 (en) | 2021-03-23 |
TW202021583A (en) | 2020-06-16 |
CL2021000289A1 (en) | 2021-08-27 |
US20220313661A1 (en) | 2022-10-06 |
US20200054607A1 (en) | 2020-02-20 |
EP3836920A1 (en) | 2021-06-23 |
CA3104695A1 (en) | 2020-02-20 |
JP7469293B2 (en) | 2024-04-16 |
JP2021534189A (en) | 2021-12-09 |
MX2021001761A (en) | 2021-04-19 |
AU2019321583A1 (en) | 2021-01-21 |
CN112804998A (en) | 2021-05-14 |
EA202190561A1 (en) | 2021-05-26 |
MA53238A (en) | 2022-04-13 |
KR20210046708A (en) | 2021-04-28 |
IL280906A (en) | 2021-04-29 |
SG11202101393PA (en) | 2021-03-30 |
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