WO2020017915A1 - Composition pharmaceutique comprenant du phytoncide pour la prévention ou le traitement de la sarcopénie - Google Patents

Composition pharmaceutique comprenant du phytoncide pour la prévention ou le traitement de la sarcopénie Download PDF

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Publication number
WO2020017915A1
WO2020017915A1 PCT/KR2019/008917 KR2019008917W WO2020017915A1 WO 2020017915 A1 WO2020017915 A1 WO 2020017915A1 KR 2019008917 W KR2019008917 W KR 2019008917W WO 2020017915 A1 WO2020017915 A1 WO 2020017915A1
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WO
WIPO (PCT)
Prior art keywords
pharmaceutical composition
preventing
myostatin
phytoncide
myopathy
Prior art date
Application number
PCT/KR2019/008917
Other languages
English (en)
Korean (ko)
Inventor
김현수
Original Assignee
고려대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020190086337A external-priority patent/KR102332654B1/ko
Application filed by 고려대학교 산학협력단 filed Critical 고려대학교 산학협력단
Publication of WO2020017915A1 publication Critical patent/WO2020017915A1/fr

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system

Definitions

  • a pharmaceutical composition for preventing or treating myopathy containing phytoncide as an active ingredient.
  • Figure 3 confirms the effect of inhibiting the increased MURF1 protein expression by UV during treatment with cariophyllene oxide and cedrol.
  • composition of the present invention can inhibit the expression of mRNA or protein of myostatin, MUFR1, and Foxo3, which are known as indices of myopathy, in particular myostatin expression by bleomycin or UV stimulation. Can be suppressed.
  • the bleomycin is an anti-tumor antibiotic and is used as an effective anticancer agent for squamous cell carcinoma or malignant lymphoma, or is known as an aging-inducing factor.
  • the diluent may be a non-aqueous solvent such as propylene glycol, polyethylene glycol, vegetable oils such as olive oil and peanut oil, or brine (preferably 0.8% saline), water containing a buffer medium (preferably 0.05M phosphate buffer)
  • aqueous solvent such as these, etc. are mentioned, but it is not limited to this.
  • the food to which the substance can be added include dairy products including meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gum, ice cream, various soups, drinks, tea, drink, Alcoholic beverages and vitamin complexes, and the like and include all of the health foods in the conventional sense.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un mode de réalisation de la présente invention concerne une composition pharmaceutique comprenant un phytoncide en tant que principe actif pour prévenir ou traiter la sarcopénie et une composition alimentaire comprenant un phytocide en tant que principe actif pour prévenir ou soulager la sarcopénie.
PCT/KR2019/008917 2018-07-19 2019-07-19 Composition pharmaceutique comprenant du phytoncide pour la prévention ou le traitement de la sarcopénie WO2020017915A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2018-0084051 2018-07-19
KR20180084051 2018-07-19
KR10-2019-0086337 2019-07-17
KR1020190086337A KR102332654B1 (ko) 2018-07-19 2019-07-17 피톤치드를 함유하는 근감소증의 예방 또는 치료용 약학적 조성물

Publications (1)

Publication Number Publication Date
WO2020017915A1 true WO2020017915A1 (fr) 2020-01-23

Family

ID=69164547

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2019/008917 WO2020017915A1 (fr) 2018-07-19 2019-07-19 Composition pharmaceutique comprenant du phytoncide pour la prévention ou le traitement de la sarcopénie

Country Status (1)

Country Link
WO (1) WO2020017915A1 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101544515B1 (ko) * 2015-03-06 2015-08-17 고려대학교 산학협력단 피톤치드 유래 이소프레노이드를 함유하는 당뇨병 치료용 조성물
US20160089340A1 (en) * 2014-09-26 2016-03-31 Samsung Electronics Co., Ltd. Composition comprising farnesol and use thereof
KR20170042252A (ko) * 2015-10-08 2017-04-18 주식회사 엘지생활건강 세드롤 및 콜라겐 유래 펩타이드를 포함하는 피부 개선용 조성물
WO2017065077A1 (fr) * 2015-10-16 2017-04-20 株式会社カネカ Agent de renforcement musculaire
KR101767603B1 (ko) * 2016-02-05 2017-08-11 한국생명공학연구원 베타카리오필렌알코올 또는 이의 약학적으로 허용 가능한 염을 포함하는 근력약화 관련 질환의 예방 또는 치료용 약학적 조성물
WO2018236186A1 (fr) * 2017-06-23 2018-12-27 연세대학교 산학협력단 Composition comprenant un dérivé de sesquiterpène en tant que principe actif pour la prévention ou le traitement de maladies musculaires
WO2019017677A2 (fr) * 2017-07-18 2019-01-24 연세대학교 산학협력단 Composition comprenant du citral utilisé comme principe actif pour présenter un effet de raffermissement musculaire, de renforcement musculaire, de différenciation musculaire, de régénération musculaire ou de suppression de sarcopénie

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160089340A1 (en) * 2014-09-26 2016-03-31 Samsung Electronics Co., Ltd. Composition comprising farnesol and use thereof
KR101544515B1 (ko) * 2015-03-06 2015-08-17 고려대학교 산학협력단 피톤치드 유래 이소프레노이드를 함유하는 당뇨병 치료용 조성물
KR20170042252A (ko) * 2015-10-08 2017-04-18 주식회사 엘지생활건강 세드롤 및 콜라겐 유래 펩타이드를 포함하는 피부 개선용 조성물
WO2017065077A1 (fr) * 2015-10-16 2017-04-20 株式会社カネカ Agent de renforcement musculaire
KR101767603B1 (ko) * 2016-02-05 2017-08-11 한국생명공학연구원 베타카리오필렌알코올 또는 이의 약학적으로 허용 가능한 염을 포함하는 근력약화 관련 질환의 예방 또는 치료용 약학적 조성물
WO2018236186A1 (fr) * 2017-06-23 2018-12-27 연세대학교 산학협력단 Composition comprenant un dérivé de sesquiterpène en tant que principe actif pour la prévention ou le traitement de maladies musculaires
WO2019017677A2 (fr) * 2017-07-18 2019-01-24 연세대학교 산학협력단 Composition comprenant du citral utilisé comme principe actif pour présenter un effet de raffermissement musculaire, de renforcement musculaire, de différenciation musculaire, de régénération musculaire ou de suppression de sarcopénie

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