WO2019241273A1 - Lineage tracing using mitochondrial genome mutations and single cell genomics - Google Patents

Lineage tracing using mitochondrial genome mutations and single cell genomics Download PDF

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Publication number
WO2019241273A1
WO2019241273A1 PCT/US2019/036583 US2019036583W WO2019241273A1 WO 2019241273 A1 WO2019241273 A1 WO 2019241273A1 US 2019036583 W US2019036583 W US 2019036583W WO 2019241273 A1 WO2019241273 A1 WO 2019241273A1
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WO
WIPO (PCT)
Prior art keywords
cells
cell
mutations
seq
mitochondrial
Prior art date
Application number
PCT/US2019/036583
Other languages
French (fr)
Inventor
Jacob C. ULIRSCH
Aviv Regev
Caleb A. LAREAU
Leif S. LUDWIG
Vijay G. Sankaran
Jason Buenrostro
Original Assignee
The Broad Institute, Inc.
Massachusetts Institute Of Technology
The Children’s Medical Center Corporation
President And Fellows Of Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority to US201862683502P priority Critical
Priority to US62/683,502 priority
Priority to US201962838639P priority
Priority to US62/838,639 priority
Application filed by The Broad Institute, Inc., Massachusetts Institute Of Technology, The Children’s Medical Center Corporation, President And Fellows Of Harvard College filed Critical The Broad Institute, Inc.
Publication of WO2019241273A1 publication Critical patent/WO2019241273A1/en

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