WO2019186304A1 - Method to generate an energy wavefront - Google Patents

Method to generate an energy wavefront Download PDF

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Publication number
WO2019186304A1
WO2019186304A1 PCT/IB2019/051924 IB2019051924W WO2019186304A1 WO 2019186304 A1 WO2019186304 A1 WO 2019186304A1 IB 2019051924 W IB2019051924 W IB 2019051924W WO 2019186304 A1 WO2019186304 A1 WO 2019186304A1
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WIPO (PCT)
Prior art keywords
wave
sonic
method
ultrasonic
mm
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PCT/IB2019/051924
Other languages
French (fr)
Inventor
Ramchandran Shankarshastri TRICHUR
Original Assignee
RAMCHANDRAN, Shankar Trichur
RAMCHANDRAN, Jaishree Trichur
Iyer, Lakshmi
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Priority to IN201821010914 priority Critical
Priority to IN201821010914 priority
Application filed by RAMCHANDRAN, Shankar Trichur, RAMCHANDRAN, Jaishree Trichur, Iyer, Lakshmi filed Critical RAMCHANDRAN, Shankar Trichur
Publication of WO2019186304A1 publication Critical patent/WO2019186304A1/en

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B06GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
    • B06BMETHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
    • B06B1/00Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency
    • B06B1/02Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy
    • B06B1/06Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezo-electric effect or with electrostriction
    • B06B1/0644Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezo-electric effect or with electrostriction using a single piezo-electric element
    • GPHYSICS
    • G10MUSICAL INSTRUMENTS; ACOUSTICS
    • G10KSOUND-PRODUCING DEVICES; METHODS OR DEVICES FOR PROTECTING AGAINST, OR FOR DAMPING, NOISE OR OTHER ACOUSTIC WAVES IN GENERAL; ACOUSTICS NOT OTHERWISE PROVIDED FOR
    • G10K11/00Methods or devices for transmitting, conducting or directing sound in general; Methods or devices for protecting against, or for damping, noise or other acoustic waves in general
    • G10K11/18Methods or devices for transmitting, conducting, or directing sound
    • G10K11/26Sound-focusing or directing, e.g. scanning
    • G10K11/28Sound-focusing or directing, e.g. scanning using reflection, e.g. parabolic reflector
    • GPHYSICS
    • G10MUSICAL INSTRUMENTS; ACOUSTICS
    • G10KSOUND-PRODUCING DEVICES; METHODS OR DEVICES FOR PROTECTING AGAINST, OR FOR DAMPING, NOISE OR OTHER ACOUSTIC WAVES IN GENERAL; ACOUSTICS NOT OTHERWISE PROVIDED FOR
    • G10K9/00Devices in which sound is produced by vibrating a diaphragm or analogous element, e.g. fog horns, vehicle hooter, buzzer
    • G10K9/12Devices in which sound is produced by vibrating a diaphragm or analogous element, e.g. fog horns, vehicle hooter, buzzer electrically operated
    • G10K9/122Devices in which sound is produced by vibrating a diaphragm or analogous element, e.g. fog horns, vehicle hooter, buzzer electrically operated using piezo-electric driving means

Abstract

A method for generating an energy wavefront is disclosed. The method includes receiving, at a transducer device, a combined ultrasonic and sonic waveform signal; creating a combined ultrasonic and sonic wave based on the combined ultrasonic and sonic waveform signal, using the transducer device; creating a primary standing wave; creating a secondary standing wave;and using a parabolic reflector to shape, reflect and transmit the energy wavefront, wherein the energy wavefront includes wave elements of one or more of the combined ultrasonic and sonic wave, the primary standing wave and the secondary standing wave. An exemplary system to implement the method is elaborated upon.

Description

METHOD TO GENERATE AN ENERGY WAVEFRONT

TECHNICAL FIELD

[0001] The present disclosure relates generally to generation and transmission of energy waves, e.g., sonic waves and ultrasonic waves transmitted through air medium, and particularly to a method for generating a non-contact, non-invasive, airborne toroidal shaped, encapsulated sonic and ultrasonic energy wavefront, useful in medical treatments, such as but not limited to, stimulation of cell metabolism, targeted tissue and organ re-vitalization, enhancing drug delivery and efficiency, and other non-medical uses, such as but not limited to, non-destructive testing of structures.

BACKGROUND

[0002] Background description includes information that may be useful in understanding the present invention. It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art.

[0003] Researches indicate that cells/organs/living organisms respond to internal as well as external surroundings. It has been observed that a slight change in pH levels within a cell can actuate a certain protein synthesis and can halt another for the same function. For example, a carcinogen is needed to trigger a change in behavior of a healthy cell and make the cell start expressing proteins which turn the cells cancerous. If an unhealthy change in environment can alter the state of a cell, then the converse should be true too. A healthy environment should trigger a healthy change.

[0004] Autonomic nervous system (ANS) in human beings is a control system that acts largely unconsciously and regulates bodily functions such as heart rate, digestion, respiratory rate, pupillary response, urination, and sexual arousal to name a few. Humans do not have much control over their heart rate or breathing. However, a soothing melody lowers our heart rate, hearing a loud explosion leads to higher heart palpitations. Such bodily functions are governed by the ANS through cells and organs present throughout body of a human being.

[0005] It has been envisaged that sound and vibrations bypass the conscious mind and have a direct effect on the ANS, thus, releasing regulatory hormones and enzymes and changing internal as well as external environment of various cells and organs. It is also a well researched fact that every healthy living organism/cell resonates within a defined frequency range. Also, for unhealthy/sick cells the defined frequency range changes that leads to losing of desired vibrancy and vitality of the unhealthy/sick cells. Further, imposing external electromagnetic stimulation like radio waves disturbs vibrancy and vitality of healthy cells, impacts its resonance and eventually causing cell lysis, a medical condition that refers to the breaking down of membrane of a cell, often by viral, enzymic, or osmotic mechanisms that compromise integrity of the cell.

[0006] Ultrasound (ultrasonic) waves which are routinely used for diagnostic applications throughout the world are now being adopted in various fields of drug delivery systems and other therapeutic use. Acoustic interactions of ultrasound with biological tissues play an important role in biomedical applications of ultrasound. Low intensity ultrasonic is known to permeate the skin, modulate the cell membrane and alter its properties possibly activating signal transduction pathways. The energy absorbed by the enzymes from the ultrasonic effects the overall function of the cell.

[0007] Currently available ultrasonic transducer assemblies to stimulate cell metabolism are primarily based around a single resonant ultrasound frequency and do not provide for generation of variable amplitude/intensity nor wide -band multi— resonant frequency response.

[0008] Also, current contact methods of ultrasound transmission to tissue rely on transmissive gels for maximum power transmission from transducer to tissue. Area of treatment is limited to transducer / applicator head area. Airborne ultrasound transmission is not only non-contact and non-invasive but treatment is more holistic and the area of treatment is not limited to just the transducer area. In fact, treatment is not limited to single patient, multiple persons having same ailment can receive airborne ultrasound from same device.

[0009] There is therefore a need in the art to provide a method for generating an energy wavefront including any or a combination of ultrasonic waves and sonic waves to obtain airborne, non-contact, variable-intensity, multi-frequency, multi-beam and multi-directional energy waves capable of generating ultrasonic and sonic vibrations.

[0010] As used in the description herein and throughout the claims that follow, the meaning of“a,”“an,” and“the” includes plural reference unless the context clearly dictates otherwise. Also, as used in the description herein, the meaning of“in” includes“in” and“on” unless the context clearly dictates otherwise.

[0011] In some embodiments, the numerical parameters set forth in the written description and attached claims are approximations that can vary depending upon the desired properties sought to be obtained by a particular embodiment. In some embodiments, the numerical parameters should be construed in light of the number of reported significant digits and by applying ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of some embodiments of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as practicable. The numerical values presented in some embodiments of the invention may contain certain errors necessarily resulting from the standard deviation found in their respective testing measurements.

[0012] The recitation of ranges of values herein is merely intended to serve as a shorthand method of referring individually to each separate value falling within the range. Unless otherwise indicated herein, each individual value is incorporated into the specification as if it were individually recited herein. All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g.“such as”) provided with respect to certain embodiments herein is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention otherwise claimed. No language in the specification should be construed as indicating any non-claimed element essential to the practice of the invention.

[0013] Groupings of alternative elements or embodiments of the invention disclosed herein are not to be construed as limitations. Each group member can be referred to and claimed individually or in any combination with other members of the group or other elements found herein. One or more members of a group can be included in, or deleted from, a group for reasons of convenience and/or patentability. When any such inclusion or deletion occurs, the specification is herein deemed to contain the group as modified thus fulfilling the written description of all groups used in the appended claims.

OBJECTS OF THE INVENTION

[0014] A general object of the present disclosure is to provide a method for generating on-invasive, non-contact, airborne, variable-intensity multi-beam and multi-directional energy wavefront comprising any or a combination of ultrasonic waves and sonic waves.

[0015] Another object of the present disclosure is to provide a method for generating a multi-beam and multi-directional energy wavefront having multiple resonant frequencies spanning over various sonic and ultrasonic ranges to have a wide band response to target different diseases and organs with specific frequency and intensity. [0016] Another object of the present disclosure is to provide a method for generating a multi-beam and multi-directional energy wavefront to obtain multi-beam and multi directional wavefront with variable amplitude/intensity.

[0017] Yet another object of the present disclosure is to provide a method for generating, shaping as well as scattering a primary wavefront generated by a piezoelectric crystal.

[0018] Still another object of the present disclosure is to provide a system and method for generating on-invasive, non-contact, airborne, variable-intensity, multi-frequency, multi beam and multi-directional energy wavefront that creates a vibrational environment to stimulate cells of human body into a nascent state using the energy waves generated thereof.

SUMMARY

[0019] The present disclosure relates to method for generating an energy wavefront that is useful in medical treatments such as but not limited to stimulation of cell metabolism, and as well useful in other non-medical uses such as but not limited to non-destructive testing of structures.

[0020] In an aspect, present disclosure elaborates upon a method for generating an energy wavefront. The method can include: receiving, at a transducer device, a combined ultrasonic and sonic waveform signal; creating a combined ultrasonic and sonic wave based on the combined ultrasonic and sonic waveform signal, using the transducer device; creating a primary standing wave between the transducer device and a first resonator device, wherein the first resonator device can be located on one side of the transducer device and the primary standing wave can be created due to interaction or resonance between the combined ultrasonic and sonic wave and a reflection of the combined ultrasonic and sonic wave from the first resonator device; creating a secondary standing wave between the transducer device and a second resonator plate located on an other side of the transducer device, wherein the second resonator plate can be placed towards the center of a grill and wherein the secondary standing wave can be created due to the interaction or resonance between the combined ultrasonic and sonic wave and a reflection of the combined ultrasonic and sonic wave from the second resonator plate; and using a parabolic reflector to shape, reflect and transmit the energy wavefront, wherein the energy wavefront can include wave elements of one or more of the combined ultrasonic and sonic wave, the primary standing wave and the secondary standing wave. [0021] In another aspect, the wave elements can include one or more of the following: parts of, combinations of, reflections of, deflections of, interferences of, resonances of, cross talk between, attenuations of, and modifications of one or more of the combined ultrasonic and sonic wave, the primary standing wave and the secondary standing wave.

[0022] In yet another aspect, the transducer device can be any or a combination of a piezoelectric crystal positioned on a substrate such that the piezoelectric crystal has a dead zone towards its center and the combined ultrasonic and sonic wave that it creates has a hollow cylindrical shape, and a device that converts a combined ultrasonic and sonic waveform signal into a combined ultrasonic and sonic wave having a hollow cylindrical shape.

[0023] In an aspect, the first resonator device can be a cavity resonator, and the cavity resonator can include a hollow cylinder with one end placed on one side of the transducer device and the other end having a first resonator plate.

[0024] In another aspect, the parabolic reflector can be placed at the periphery of and can surround the transducer device and first resonator device, such that the transducer device and first resonator device are at focal point area of the parabolic reflector.

[0025] In yet another aspect, the grill can be positioned facing and in close proximity to the parabolic reflector such that the second resonator plate is in front of the other side of the transducer device.

[0026] In an aspect, the combined ultrasonic and sonic wave can have a hollow cylindrical shape.

[0027] In another aspect, the energy wavefront can be in the form of a donut shaped toroidal wavefront.

[0028] In yet another aspect, the energy wavefront can be scattered by the grill to make it multi-beam and multi-directional.

[0029] In an aspect, the interaction or resonance between the combined ultrasonic and sonic wave and the reflection can induce necessary attenuation and tuning of the primary standing wave.

[0030] In another aspect, the combined ultrasonic and sonic waveform signal can be created by combining a sonic wave signal and ultrasonic wave signal, and the combined ultrasonic and sonic waveform signal can include the sonic wave signal encapsulated in the ultrasonic wave signal or vice versa. [0031] In yet another aspect, the amplitude of the primary standing wave can be modulated.

[0032] In an aspect, the method further can include any or a combination of: modulating amplitude of the combined ultrasonic and sonic wave; modulating amplitude of the primary standing wave; modulating parabolic spin angle of the energy wavefront; blocking any or a combination of the combined ultrasonic and sonic wave and the primary and secondary standing waves; and slicing off the combined ultrasonic and sonic wave at appropriate angles using the grill.

[0033] In another aspect, the parabolic reflector can include a cavity surrounded by a tapered surface, the tapered surface bound by a taper angle of about 30 to 50 degrees with a longitudinal surface of the parabolic reflector.

[0034] In yet another aspect, thickness of the grill can range from about 1.5 millimeter (mm) to 4 mm, it can have slots extending up to a thickness of about 3 mm, and it can be in form of a disc of diameter from about 18.05 mm to about 45 mm.

[0035] In an aspect, the piezoelectric crystal can include a metal substrate disc of diameter from about 27 mm to 40 mm that surrounds a crystal compound disc of diameter from about 20 mm to 30mm, the crystal compound disc in turn surrounding a dead zone region of diameter from about 6.5 mm to 15 mm, and the metal substrate disc can have a thickness from about 0.25 mm to about 0.5 mm.

[0036] In another aspect, diameter of the cavity resonator can range from about 30 millimeter (mm) to about 40 mm, and can be adjusted to change amplitude of the primary standing wave, and height of the cavity resonator can range from about 5 mm to about 15 mm and can be adjusted to modulate primary transmission beam angle of the combined ultrasonic and sonic wave.

[0037] In yet another aspect, the sonic wave signal can be created with frequency range between 1.5 Hz and 620 Hz, and the ultrasonic wave signal can be created with frequency range between 20 KHz and 100 KHz.

[0038] In an aspect, there can be variation in frequency of any or a combination of the sonic wave signal, the ultrasonic wave signal, and the combined ultrasonic and sonic waveform signal such that the variation in the frequency can be in an increasing sweep or a decreasing sweep or both.

[0039] In another aspect, the energy wavefront can include a multi-directional low frequency ultrasonic carrier sweep with an encapsulated multi-directional sonic frequency sweep having frequency ranges that cover natural resonant frequency range of human body as a whole as well as at cellular level.

[0040] In yet another aspect, the energy wavefront can be configured to engulf a person from all directions, and can create a vibrational environment to stimulate cells of human body into a nascent state.

[0041] In another aspect, exposure of a person to the energy wavefront can enable, for the person, any or a combination of: stimulation of cell metabolism, targeted tissue repair, diabetic foot ulcer, Venus ulcer, organ re-vitalization and enhancement of drug delivery and efficiency, modification of cell membrane permeability leading to different rates of transports of ions and molecules across the cell membrane, increase in potassium ion influx together with increase in sodium efflux without inducing cell lysis or gross membrane damage, and enhancement in intracellular concentration of calcium ions, tissue permeability, cell membrane permeability, calcium influx and release of insulin from pancreatic beta cells.

[0042] In yet another aspect, exposure of a person to the energy wavefront can lead to, for the person, any or more of: generation of micro bubbles in water and lipid bilayers of skin, improvement in the action potential of drugs, improvement in glycemic control, improvement in histological, pathological, biochemical and biomedical parameters of the person’s body, inducement of remedial natural disease-free health, increase in vitamin D and calcium levels, reduction in Alpha Glucosydase levels, assistance in drug delivery of large molecule such as B6/B12 and absorption of the same, effective regulation of Homocystein Metabolism, and improvement in immunity profile.

[0043] Those skilled in the art will further appreciate the advantages and superior features of the disclosure together with other important aspects thereof on reading the detailed description that follows in conjunction with the drawings.

BRIEF DESCRIPTION OF THE DRAWINGS

[0044] The accompanying drawings are included to provide a further understanding of the present disclosure, and are incorporated in and constitute a part of this specification. The drawings illustrate exemplary embodiments of the present disclosure and, together with the description, serve to explain the principles of the present disclosure.

[0045] FIG. 1 illustrates an exemplary flowchart representation of proposed method to generate an energy wavefront in accordance with an embodiment of the present disclosure. [0046] FIG. 2 illustrates illustrates an exemplary exploded view of an exemplary ultrasonic transducer system that can be used to implement proposed method in accordance with an embodiment of the present disclosure.

[0047] FIGs.3A through 3C illustrate exemplary representations of a cavity resonator of the exemplary ultrasonic transducer system in accordance with an embodiment of the present disclosure.

[0048] FIGs.4A through 4C illustrate exemplary representations of a piezoelectric crystal of the exemplary ultrasonic transducer system in accordance with an embodiment of the present disclosure.

[0049] FIGs.5A through 5C illustrate exemplary representations of a parabolic reflector of the exemplary ultrasonic transducer system in accordance with an embodiment of the present disclosure.

[0050] FIGs.6A through 6C illustrate exemplary representations of a wave slicer grill of the exemplary ultrasonic transducer system in accordance with an embodiment of the present disclosure.

DETAILED DESCRIPTION

[0051] The following is a detailed description of embodiments of the disclosure depicted in the accompanying drawings. The embodiments are in such details as to clearly communicate the disclosure. However, the amount of detail offered is not intended to limit the anticipated variations of embodiments; on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the present disclosure as defined by the appended claims.

[0052] If the specification states a component or feature“may”, “can”,“could”, or “might” be included or have a characteristic, that particular component or feature is not required to be included or have the characteristic.

[0053] As used in the description herein and throughout the claims that follow, the meaning of“a,”“an,” and“the” includes plural reference unless the context clearly dictates otherwise. Also, as used in the description herein, the meaning of“in” includes“in” and“on” unless the context clearly dictates otherwise.

[0054] Exemplary embodiments will now be described more fully hereinafter with reference to the accompanying drawings, in which exemplary embodiments are shown. These exemplary embodiments are provided only for illustrative purposes and so that this disclosure will be thorough and complete and will fully convey the scope of the invention to those of ordinary skill in the art. The invention disclosed may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Various modifications will be readily apparent to persons skilled in the art. The general principles defined herein may be applied to other embodiments and applications without departing from the spirit and scope of the invention. Moreover, all statements herein reciting embodiments of the invention, as well as specific examples thereof, are intended to encompass both structural and functional equivalents thereof. Additionally, it is intended that such equivalents include both currently known equivalents as well as equivalents developed in the future (i.e., any elements developed that perform the same function, regardless of structure). Also, the terminology and phraseology used is for the purpose of describing exemplary embodiments and should not be considered limiting. Thus, the present invention is to be accorded the widest scope encompassing numerous alternatives, modifications and equivalents consistent with the principles and features disclosed. For purpose of clarity, details relating to technical material that is known in the technical fields related to the invention have not been described in detail so as not to unnecessarily obscure the present invention.

[0055] Thus, for example, it will be appreciated by those of ordinary skill in the art that the diagrams, schematics, illustrations, and the like represent conceptual views or processes illustrating systems and methods embodying this invention. The functions of the various elements shown in the figures may be provided through the use of dedicated hardware as well as hardware capable of executing associated software. Similarly, any switches shown in the figures are conceptual only. Their function may be carried out through the operation of program logic, through dedicated logic, through the interaction of program control and dedicated logic, or even manually, the particular technique being selectable by the entity implementing this invention. Those of ordinary skill in the art further understand that the exemplary hardware, software, processes, methods, and/or operating systems described herein are for illustrative purposes and, thus, are not intended to be limited to any particular named element.

[0056] Each of the appended claims defines a separate invention, which for infringement purposes is recognized as including equivalents to the various elements or limitations specified in the claims. Depending on the context, all references below to the "invention" may in some cases refer to certain specific embodiments only. In other cases it will be recognized that references to the "invention" will refer to subject matter recited in one or more, but not necessarily all, of the claims.

[0057] All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g., “such as”) provided with respect to certain embodiments herein is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention otherwise claimed. No language in the specification should be construed as indicating any non-claimed element essential to the practice of the invention.

[0058] Various terms as used herein are shown below. To the extent a term used in a claim is not defined below, it should be given the broadest definition persons in the pertinent art have given that term as reflected in printed publications and issued patents at the time of filing.

[0059] Embodiments explained herein relate to a method for generating an energy wavefront useful in medical treatments such as but not limited to stimulation of cell metabolism, and as well useful in other non-medical uses such as but not limited to non destructive testing of structures.

[0060] In an aspect, present disclosure elaborates upon a method for generating an energy wavefront. The method can include: receiving, at a transducer device, a combined ultrasonic and sonic waveform signal; creating a combined ultrasonic and sonic wave based on the combined ultrasonic and sonic waveform signal, using the transducer device;creating a primary standing wave between the transducer device and a first resonator device, wherein the first resonator device can be located on one side of the transducer device and the primary standing wave can be created due to interaction or resonance between the combined ultrasonic and sonic wave and a reflection of the combined ultrasonic and sonic wave from the first resonator device; creating a secondary standing wave between the transducer device and a second resonator plate located on an other side of the transducer device, wherein the second resonator plate can be placed towards the center of a grill and wherein the secondary standing wave can be created due to the interaction or resonance between the combined ultrasonic and sonic wave and a reflection of the combined ultrasonic and sonic wave from the second resonator plate; and using a parabolic reflector to shape, reflect and transmit the energy wavefront, wherein the energy wavefront can include wave elements of one or more of the combined ultrasonic and sonic wave, the primary standing wave and the secondary standing wave.

[0061] In another aspect, the wave elements can include one or more of the following: parts of, combinations of, reflections of, deflections of, interferences of, resonances of, cross talk between, attenuations of, and modifications of one or more of the combined ultrasonic and sonic wave, the primary standing wave and the secondary standing wave.

[0062] In yet another aspect, the transducer device can be any or a combination of a piezoelectric crystal positioned on a substrate such that the piezoelectric crystal has a dead zone towards its center and the combined ultrasonic and sonic wave that it creates has a hollow cylindrical shape, and a device that converts a combined ultrasonic and sonic waveform signal into a combined ultrasonic and sonic wave having a hollow cylindrical shape.

[0063] In an aspect, the first resonator device can be a cavity resonator, and the cavity resonator can include a hollow cylinder with one end placed on one side of the transducer device and the other end having a first resonator plate.

[0064] In another aspect, the parabolic reflector can be placed at the periphery of and can surround the transducer device and first resonator device, such that the transducer device and first resonator device are at focal point area of the parabolic reflector.

[0065] In yet another aspect, the grill can be positioned facing and in close proximity to the parabolic reflector such that the second resonator plate is in front of the other side of the transducer device.

[0066] In an aspect, the combined ultrasonic and sonic wave can have a hollow cylindrical shape.

[0067] In another aspect, the energy wavefront can be in the form of a donut shaped toroidal wavefront.

[0068] In yet another aspect, the energy wavefront can be scattered by the grill to make it multi-beam and multi-directional.

[0069] In an aspect, the interaction or resonance between the combined ultrasonic and sonic wave and the reflection can induce necessary attenuation and tuning of the primary standing wave.

[0070] In another aspect, the combined ultrasonic and sonic waveform signal can be created by combining a sonic wave signal and ultrasonic wave signal, and the combined ultrasonic and sonic waveform signal can include the sonic wave signal encapsulated in the ultrasonic wave signal or vice versa.

[0071] In yet another aspect, the amplitude of the primary standing wave can be modulated.

[0072] In an aspect, the method further can include any or a combination of: modulating amplitude of the combined ultrasonic and sonic wave; modulating amplitude of the primary standing wave; modulating parabolic spin angle of the energy wavefront; blocking any or a combination of the combined ultrasonic and sonic wave and the primary and secondary standing waves; and slicing off the combined ultrasonic and sonic wave at appropriate angles using the grill.

[0073] In another aspect, the parabolic reflector can include a cavity surrounded by a tapered surface, the tapered surface bound by a taper angle of about 30 to 50 degrees with a longitudinal surface of the parabolic reflector.

[0074] In yet another aspect, thickness of the grill can range from about 1.5 millimeter (mm) to 4 mm, it can have slots extending up to a thickness of about 3 mm, and it can be in form of a disc of diameter from about 18.05 mm to about 45 mm.

[0075] In an aspect, the piezoelectric crystal can include a metal substrate disc of diameter from about 27 mm to 40 mm that surrounds a crystal compound disc of diameter from about 20 mm to 30mm, the crystal compound disc in turn surrounding a dead zone region of diameter from about 6.5 mm to 15 mm, and the metal substrate disc can have a thickness from about 0.25 mm to about 0.5 mm.

[0076] In another aspect, diameter of the cavity resonator can range from about 30 millimeter (mm) to about 40 mm, and can be adjusted to change amplitude of the primary standing wave, and height of the cavity resonator can range from about 5 mm to about 15 mm and can be adjusted to modulate primary transmission beam angle of the combined ultrasonic and sonic wave.

[0077] In yet another aspect, the sonic wave signal can be created with frequency range between 1.5 Hz and 620 Hz, and the ultrasonic wave signal can be created with frequency range between 20 KHz and 100 KHz.

[0078] In an aspect, there can be variation in frequency of any or a combination of the sonic wave signal, the ultrasonic wave signal, and the combined ultrasonic and sonic waveform signal such that the variation in the frequency can be in an increasing sweep or a decreasing sweep or both. [0079] In another aspect, the energy wavefront can include a multi-directional low frequency ultrasonic carrier sweep with an encapsulated multi-directional sonic frequency sweep having frequency ranges that cover natural resonant frequency range of human body as a whole as well as at cellular level.

[0080] In yet another aspect, the energy wavefront can be configured to engulf a person from all directions, and can create a vibrational environment to stimulate cells of human body into a nascent state.

[0081] In another aspect, exposure of a person to the energy wavefront can enable, for the person, any or a combination of: stimulation of cell metabolism, targeted tissue repair, diabetic foot ulcer, Venus ulcer, organ re-vitalization and enhancement of drug delivery and efficiency, modification of cell membrane permeability leading to different rates of transports of ions and molecules across the cell membrane, increase in potassium ion influx together with increase in sodium efflux without inducing cell lysis or gross membrane damage, and enhancement in intracellular concentration of calcium ions, tissue permeability, cell membrane permeability, calcium influx and release of insulin from pancreatic beta cells.

[0082] In yet another aspect, exposure of a person to the energy wavefront can lead to, for the person, any or more of: generation of microbubbles in water and lipid bilayers of skin, improvement in the action potential of drugs, improvement in glycemic control, improvement in histological, pathological, biochemical and biomedical parameters of the person’s body, inducement of remedial natural disease-free health, increase in vitamin D and calcium levels, reduction in Alpha Glucosydase levels, assistance in drug delivery of large molecule such as B6/B12 and absorption of the same, effective regulation of Homocystein Metabolism, and improvement in immunity profile.

[0083] Aspects of the present disclosure pertains to a method for generating an energy wavefront, the method including the steps of creating a combined ultrasonic and sonic wave (interchangeably termed as a primary wavefront herein)based on a received combined ultrasonic and sonic waveform signal by a piezoelectric crystal, wherein the piezoelectric crystal incorporates a dead zone region at center of a crystal compound disc coupled with a metal substrate disc, wherein the primary wavefront is in the form of hollowed cylinder shaped wavefront, tuning/shaping the primary wavefront to obtain multi frequency sweeping standing waves, and scattering the standing waves by a wave slicer grill ( interchangeably termed as grill herein) to obtain an airborne, variable-intensity, multi-frequency, multi-beam and multi-directional donut shaped/toroidal energy wavefront, wherein the energy wavefront includes sonic waves encapsulated by ultrasonic waves.

[0084] In an embodiment, the method further includes the step of emitting the airborne, variable-intensity, multi-frequency, multi-beam and multi-directional donut shaped/toroidal energy wavefront from the wave slicer grill to generate ultrasonic vibrations capable of stimulating cell metabolism of a human being.

[0085] In an embodiment, the dead zone region assists the piezoelectric crystal to generate the hollowed cylindrical primary wavefront that includes low frequency ultrasonic carrier sweep with encapsulated sonic waves sweep.

[0086] In an embodiment, primary standing waves are formed by interaction of the primary wavefront emitted by the piezoelectric crystal and waves reflected by a cavity resonator. In an embodiment, formation of said primary standing waves is assisted by tuning of the primary wavefront by the cavity resonator. In an embodiment, the cavity resonator tunes and locks in dynamic sweep frequencies of the primary wavefront resulting in the airborne, variable-intensity, multi frequency sweeping primary standing waves.

[0087] In an embodiment, the primary standing waves traverse through a parabolic reflector and the wave slicer grill to generate secondary standing wave that are formed by interaction of emitted and reflected primary standing waves between the parabolic reflector and the wave slicer grill, thereby reshaping the cylindrical primary wavefront into a donut/toroidal shaped secondary wavefront.

[0088] In an embodiment, the primary standing waves and the secondary standing waves are constricted to be emitted from the wave slicer grill by at least one resonator plate coupled with the wave slicer grill. The at least one resonator plate blocks the primary standing waves and the secondary standing waves to restrict their flow through slots of the wave slicer grill.

[0089] In an embodiment, the cavity resonator and the piezoelectric crystal are placed at a focal area of the parabolic reflector.

[0090] In an embodiment, the at least one resonator plate helps in attenuation of the primary wavefront and modulation of lateral traverse length of the secondary standing waves prior to emission of the energy wavefront through the wave slicer grill by changing any or a combination of diameter and shape of the at least one resonator plate.

[0091] In an embodiment, the step of scattering of the standing waves involves slicing of the secondary waves at appropriate angles. [0092] FIG. 1 illustrates an exemplary flowchart representation of proposed method to generate an energy wavefront in accordance with an embodiment of the present disclosure.

[0093] In an aspect, a method for generating an energy wavefront can include, at step 102, receiving, at a transducer device, a combined ultrasonic and sonic waveform signal, and at step 104 creating a combined ultrasonic and sonic wave based on the combined ultrasonic and sonic waveform signal, using the transducer device. The combined ultrasonic and sonic wave is interchangeably termed as a primary wavefront herein.

[0094] The method can include, at step 106, creating a primary standing wave between the transducer device and a first resonator device, wherein the first resonator device is located on one side of the transducer device and the primary standing wave is created due to the interaction or resonance between the combined ultrasonic and sonic wave and a reflection of the combined ultrasonic and sonic wave from the first resonator device, and at step 108, creating a secondary standing wave between the transducer device and a second resonator plate located on an other side of the transducer device, wherein the second resonator plate is placed towards the center of a grill and wherein the secondary standing wave is created due to the interaction or resonance between the combined ultrasonic and sonic wave and a reflection of the combined ultrasonic and sonic wave from the second resonator plate.

[0095] The method can include, at step 110, using a parabolic reflector to shape, reflect and transmit the energy wavefront, wherein the energy wavefront includes wave elements of one or more of the combined ultrasonic and sonic wave, the primary standing wave and the secondary standing wave.

[0096] In another aspect, the energy wavefront can be donut shaped/toroidal.

[0097] In yet another aspect, the primary wavefront can be scattered to obtain a defined number of beams having specific beam intensities.

[0098] FIG. 2 illustrates an exemplary exploded view of an exemplary ultrasonic transducer system that can be used to implement proposed method in accordance with an embodiment of the present disclosure.

[0099] It can be appreciated that system being described herein is an exemplary one for the purpose of elaborating upon implementation of the method. Other systems can as well be used to implement method proposed. All such systems that implement method proposed are a part of the present disclosure. [00100] In an aspect, an exemplary ultrasonic transducer system 200 to generate energy wavefront described can interchangeably be termed as Airborne Variable Intensity Multi frequency Ultrasound (AVIMFUS) system or AVIMFUS device hereafter.

[00101] System 200 can include a cavity resonator 202 to shape a primary wavefront that can be generated, in an exemplary embodiment, by a piezoelectric crystal (also referred to as piezoelectric transducer, piezoelectric plate and piezo transducer hereinafter) 204. The primary wavefront can include low frequency ultrasonic waves with encapsulated sonic waves in order to obtain multi frequency sweeping primary standing waves shown as 214.

[00102] System 200 can further include a parabolic reflector 206 to shape the primary wavefront generated by the piezoelectric crystal204, the cavity resonator 202 and piezoelectric crystal204 arranged at a location in vicinity of focal area of the parabolic reflector 206. In this manner, adjusting focal length of the parabolic reflector 206 can allow modulation of transmission beam angle of the primary wavefront beams.

[00103] In an embodiment, the ultrasonic transducer system 200 can further include a wave slicer grill 208 that can be coupled with at least one resonator plate 210 to generate secondary standing waves 2l6(as shown in FIG. 1).

[00104] Interaction and scattering can be created between the primary standing waves and the secondary standing waves to obtain an airborne, non-contact, variable-intensity, multi frequency, multi-beam and multi-directional energy wavefront that can have sonic waves encapsulated by ultrasonic waves. The wavefront can be in the form of donut shaped/toroidal energy waveform and can be emitted from the wave slicer grill 208 so as to create ultrasonic vibrations useful in medical as well as non-medical applications, such as, for stimulation of cell metabolism, for non-destructive testing of various materials to name a few.

[00105] The parabolic reflector 206 and wave slicer grill 208 can together be termed as secondary wave shaping and scattering unit that can generate secondary standing waves 216 and can further create interaction and scattering between the primary standing waves and said secondary standing waves to obtain energy wavefront as described above.

[00106] In an embodiment, the ultrasonic transducer system 200 can emit the multi-beam and multi-direction donut shaped/toroidal energy wavefront2l2 that includes multi directional low frequency ultrasonic carrier sweep with an encapsulated multi-directional sonic frequency sweep having frequency range that covers natural resonant frequency range of human body as a whole as well as at cellular level in order to effectively stimulate and/or module cell metabolism of the human body. [00107] In an embodiment, the toroidal energy wavefront2l2 can be donut shaped and have toroidal vertices. The energy wavefront2l2 generated can be similar to that based on smoke ring effect.

[00108] FIGs.3A through 3C illustrate exemplary representations of a cavity resonator that may be used in ultrasonic transducer system as elaborated above to implement proposed method, in accordance with an exemplary embodiment of the present disclosure.

[00109] As described above, an ultrasonic transducer system 200 may be used to implement proposed method. System 200 has a cavity resonator 202 that is elaborated herein.

[00110] FIGs.3A through 3C illustrate exemplary perspective view, rear view and a sectional view of section B-B of cavity resonator 202 of system 200 in accordance with an embodiment of the present disclosure. In an embodiment, the cavity resonator 202 can shape the primary wavefront in order to obtain multi frequency sweeping primary standing waves 214. The primary standing waves 2l4(as shown in FIG. 2) are formed by interference of at least two waves of identical frequency with one another while travelling in opposite directions along the same medium. In an embodiment, the cavity resonator 202 can generate multi frequency sweeping primary standing waves 214 by shaping/tuning at least a portion of the primary wavefront. In an embodiment, the primary wavefront generated by the piezoelectric crystal204 traverses through the cavity resonator 202 and when waves emitted by the piezoelectric crystal 204 and waves reflected by the cavity resonator 202 intersect, primary standing waves 214 are formed.

[00111] In an embodiment, the cavity resonator 202 can have a plurality of slots 302 to allow electrical connection of the piezoelectric crystal204 with a waveform/wave pattem/wave signal generating device with the help of wires traversing through the slots302.

[00112] In an embodiment, the cavity resonator 202 can tune and lock in dynamic sweep frequencies of the primary wavefront resulting in the multi frequency sweeping primary standing waves 214. The piezoelectric crystal204 can be coupled to one end of the cavity resonator 202, thereby making the cavity resonator 202 a hollow cylinder with both ends capped.

[00113] In an embodiment, diameter of the cavity resonator 202 can range between 30 mm and 40 mm. Amplitude of the resulting primary standing waves 214 can be modulated by changing diameter of the cavity resonator 202. In an embodiment, height of the cavity resonator 202 can range between 5 mm and 15 mm, which can be adjusted to modulate primary transmission beam angle of the primary wavefront. The cavity resonator 202 can compensate for any tolerances of resonant frequency of the piezoelectric crystal204.

[00114] FIGs. 4A through 4C illustrate exemplary representations of a piezoelectric crystal of the exemplary ultrasonic transducer system in accordance with an embodiment of the present disclosure.

[00115] As described above, an ultrasonic transducer system 200 may be used to implement proposed method. System 200 has a piezoelectric crystal 204 that is elaborated herein.

[00116] FIGs.4A through 4C illustrate exemplary perspective view, rear view and a sectional view of section B-B of the piezoelectric crystal204 (also referred to as piezoelectric transducer, piezoelectric crystal and piezoelectric plate hereinafter) of an ultrasonic transducer system respectively in accordance with an embodiment of the present disclosure. In an aspect, the piezoelectric crystal204 includes a metal substrate disc 402 arranged concentrically with a crystal compound disc 404 that contains a crystal elements, such as, quartz, Rochelle salt and other ceramic as well as non-ceramic materials. The crystal compound disc 404 includes a dead zone region 406 at its center for creating toroidal wavefronts. The metal substrate disc 402 can be coupled with the crystal compound disc 404 by a fastening technique, such as, adhesion, welding, fitting and the likes.

[00117] In an aspect, the dead zone region 406 assists the piezoelectric crystal204 to generate the primary wavefront that includes low frequency ultrasonic waves with encapsulated sonic waves. In an embodiment, resonant sonic frequency of the piezoelectric crystal204 can range between 20 kHz to 100 kHz. In an embodiment, resonant ultrasonic frequency of the piezoelectric crystal204 can range between 1.5 Hz to 620 kHz.

[00118] In an embodiment, shape of the crystal compound disc 404 assists in generation of a plane ultrasonic wave. However, it would be appreciated that crystal compound disc 404 of a different shape such as a crystal disc having a curve on its radiating surface can be used to generate a slightly concave or bowl shape ultrasonic wave that can focus/converge at a specific point.

[00119] In an embodiment, the piezoelectric crystal204 covers a broad coverage of the over defined sonic and ultrasonic ranges. In an embodiment, the piezoelectric crystal204 has a flat band response for all of its resonant frequencies.

[00120] In an embodiment, the primary wavefront after being shaped by the cavity resonator 202 passes to a secondary wave shaping and scattering unit ( that can comprise parabolic reflector 206 and wave slicer grill 208 assembled as illustrated in FIG. 2). In an embodiment, the cavity resonator 202 can compensate for resonant frequency tolerances of the piezoelectric crystal204.

[00121] In an embodiment, resonant sonic frequency of the piezoelectric crystal204 can range between 20 kHz and 100 kHz. In an embodiment, resonant ultrasonic frequency of the piezoelectric crystal 204 can range between 1.5 Hz and 620 kHz.

[00122] In an embodiment, the metal substrate disc 402 can be arranged concentrically with the crystal compound disc 404.

[00123] In an embodiment, diameter of the metal substrate disc 402 can range between 27 mm and 40 mm. In an embodiment, diameter of the crystal compound disc 404 can range between 20 mm and 30 mm. In an embodiment, diameter of the dead zone region 406 can range between 6.5 mm and 15 mm. In an embodiment, thickness of the metal substrate disc 302 can range between 0.25 mm and 0.5 mm.

[00124] In an embodiment, the piezoelectric crystal204 can be formulated as to obtain emit a wide band piezoelectric crystal capable of generating multi-frequency resonant waves such that the resonant waves encompass multiple desired frequencies. Special doping techniques can be implemented and various compounds in correct proportions used in formulation of the proposed piezoelectric crystal204. In a way, the multi resonant piezo electric transducer/plate204 is a combination of many single frequency crystals into one.

[00125] In an embodiment, the dead zone region 406 can give rise to a suppressed dead zone region 220 (as show in FIG. 2) in the interstitial space between the piezoelectric crystal204 and the cavity resonator 202.

[00126] FIGs. 5A through 5C illustrate exemplary representations of a parabolic reflector of the exemplary ultrasonic transducer system in accordance with an embodiment of the present disclosure.

[00127] As described above, an ultrasonic transducer system 200 may be used to implement proposed method. System 200 has a parabolic reflector 206 .as shown in FIG. 2, further elaborated herein

[00128] FIGs. 5A to 5C illustrate exemplary perspective view, front view and a sectional view of section C-C of the parabolic reflector 206. Parabolic reflector 206 can include a cavity 502 surrounded by a tapered surface 504. The tapered surface 504 can be bound by a taper angle of about 30 to 50 degrees with a longitudinal surface of the parabolic reflector 206. In an embodiment, the parabolic reflector 206 can shape the primary wavefront generated by the piezoelectric crystal204 arranged at a location in vicinity of focal area of the parabolic reflector 206. In an embodiment, the parabolic reflector 206 can assist in modulation of transmission beam angle of the primary wavefront beams by adjusting focal length of the parabolic reflector 206.

[00129] In an embodiment, the primary wavefront can be in the form of donut shaped/toroidal waves generated by the piezoelectric crystal204 that is coupled to a focal area of the parabolic reflector 206.

[00130] FIGs.6A through 6C illustrate exemplary representations of a wave slicer grill of the exemplary ultrasonic transducer system in accordance with an embodiment of the present disclosure.

[00131] As described above, an ultrasonic transducer system 200 may be used to implement proposed method. System 200 has wave slicer grill 208 as shown in FIG. 2, further elaborated herein

[00132] FIGs.6A through 6C illustrate exemplary perspective view, front view and rear view of wave slicer grill 208.

[00133] In an aspect, the wave slicer grill 208 can include a plurality of slots 602 to segregate the primary wavefront shaped by the parabolic reflector 206 into a plurality of beams as to obtain multi -beam energy wavefront as output of the wave slicer grill 208. In an embodiment, the plurality of slots 602 further direct the plurality of beams of the primary wavefront into multiple directions to obtain multi-directional energy wavefront as output of the wave slicer grill 208.

[00134] In an embodiment, the wave slicer grill 208 can be coupled with at least one resonator plate 210 to generate secondary standing waves 2l6(as shown in FIG. 2) having constant peaks with amplitude of such standing waves at a point in space varying with time, but their phase staying constant with respect to time. In an embodiment, the at least one resonator plate 210 can assist in attenuation of the primary wavefront and lateral traverse length of the secondary standing waves 216 prior to emission of the energy waves through the wave slicer grill 208. In an embodiment, attenuation of the primary wavefront and lateral traverse length of the secondary standing waves 216 are dependent on diameter and shape of the at least one resonator plate 210 and can be modulated by changing any or a combination of the diameter and shape of the at least one resonator plate 210.

[00135] In an embodiment, the primary standing waves 214 are generated as a result of interaction of the emitted waves and reflected waves between a cavity resonator 202and piezoelectric crystal204. The piezoelectric crystal 204 is the primary source emitting the primary wavefront that are tuned inside the cavity resonator 202 to generate the primary standing waves 214. The primary standing waves 214 as they traverse through the parabolic reflector 206 and the wave slicer grill 208 create secondary standing waves 216. This interaction and cross talk produces a toroidal/donut shaped wavefront which is sliced at appropriate angles at the wave slicer grill, thereby generating a multi-directional energy wavefront capable of engulfing a subject being treated by the wave generating device from all directions.

[00136] In an embodiment, the parabolic reflector 206 and the wave slicer grill 208 can be construed as the secondary wave shaping and scattering unit that can be configured to modulate parabolic spin angle of the energy wavefront, to block at least a portion of the primary wavefront and the secondary standing waves 216, to modulate amplitude of the primary wavefront, and to slice off the primary wavefront at appropriate grill angles so as to obtain the donut shaped/toroidal multi-beam and multi-directional energy waveform as output of the secondary wave shaping and scattering unit. In an embodiment, prior to emission of the energy wavefront2l2 from the wave slicer grill 208, pressure waves 218 (as shown in FIG. 2) can be generated using the wave slicer grill 208 to assist generation of the donut shaped/toroidal energy wavefront2l2.

[00137] In an embodiment, thickness of the wave slicer grill 208 can range between 5.5 mm and 6.5 mm with the plurality of slots 602 extending up to a thickness of 3 mm.

[00138] In an embodiment, the wave slicer grill 108 can be in the form of a disc with diameter of the wave slicer grill 108 ranging between 18.05 mm and 22.05 mm.

[00139] AVIMFUS described herein is a system for alternative, non-invasive methods and particularly directed towards a method for generating a non-contact, non-invasive, airborne toroidal shaped, encapsulated energy wavefront having sonic waves encapsulated by ultrasound/ultrasonic waves, useful in medical treatments, such as but not limited to, stimulation of cell metabolism, targeted tissue repair (Diabetic foot ulcer and Venus ulcer and all other types wounds) and organ re-vitalization, enhancing drug delivery and efficiency, and other non-medical uses, such as but not limited to, non-destructive testing of structures.

[00140] Mechanical effects of AVIMFUS modify cell membrane permeability leading to different rates of transports of ions and molecules across the cell membrane. Exposure to AVIMFUS leads to increase in potassium ion influx together with increase in sodium efflux, without inducing cell lysis or gross membrane damage. An increase in the intracellular concentration of calcium ions can be seen to occur after exposure to AVIMFUS. Further, AVIMFUS works on the Thermal and Non-Thermal principles of Ultrasound physics known as Cavitations, Acoustic Streaming, Micro bubbles, Sonoporation, and Sonophoresis and are the possible mechanism for enhanced tissue permeability. AVIMFUS effects help enhances calcium influx and the release of insulin from pancreatic beta cells.

[00141] AVIMFUS can generate micro bubbles in water and lipid bilayers of the skin and can increase permeability of cell membrane to drugs delivered by the process of acoustic streaming and sonophoresis through mechano transduction.

[00142] AVIMFUS improves the action potential of drugs, and further improves glycemic control. Therapeutic use of AVIMFUS airborne ultrasound induce, improvise, regain, rebuild, repair, alter and treat diseased human immunological system there by improving histological, pathological, biochemical andbiomedical parameters of diseased human body and also induce remedial natural disease-free health. AVIMFUS also helps in increasing Vitamin D and calcium levels in patients, thus, reducing Alpha Glucosydase levels.

[00143] AVIMFUS can be very effective in treatment of Diabetic foot ulcer, Venus ulcer and all other types of wounds. AVIMFUS is useful for drug delivery of large molecule such as B6/B12 and absorption of the same. Also, AVIMFUS is useful for better management of diabetes and associated vascular and cardio vascular complications. It has potential in preventing the future onset on diabetic nephropathy, neuropathy, retinopathy and other associated complications because of poor glycemic control.

[00144] Due to proper management of Diabetes, Homocystien Metabolism can be regulated effectively, Vitamin D and calcium Metabolism can be regulated effectively and immune profile of a subject can be improved. When Vitamin B6/B12 absorption is increased overall reduction in inflammation in the body comes down. Hence absorption of calcium and vitamin D is increased. This results in reduced resistance to Peripheral insulin, reduction in alpha and beta cell dysfunction, and increases in insulin production. Better glycemic control by using the proposed AVIMFUS improves reduction and reversal of neuro and muscular degeneration in the body.

[00145] Hyperhomocystenemia plays a key role in the development of diabetes and associated complications. A marked retard in plasma homocysteine level was noticed in combined therapy using AVIMFUS compared with patients treated only with conventional drug. Vitamin D deficiency is most commonly observed in diabetic patients, which is one of the most important risk factors responsible for development of various vascular complications among those patients. The airborne ultrasound emitted by the AVIMFUS exerted beneficial effect in increasing the level perhaps through glycemic control, anti inflammatory, anti- oxidant and homocysteine lowering effects and increase in calcium levels.

[00146] It would be appreciated that the proposed AVIMFUS device is a better remedial measure for the management of diabetes and associated vascular complications and cardio vascular complications. It has potential in preventing the future onset on diabetic nephropathy, neuropathy, retinopathy and other associated complications because of better glycemic control. The exposure with AVIMFUS after a specific duration of meals may have action in decreasing the body weight gain and anti- hyperglycemic episodes. The reduction in body inflammations indicated the reduced risk of adverse cardiac event among diabetic patients. Similarly, the decline in plasma homocysteine level is indicative of prevention from endothelial dysfunction.

[00147] A study was conducted to compare the efficacy and safety of non-contact, low frequency airborne ultrasonic therapy using proposed method as described herein and standard treatment with sham therapy added to standard treatment in patients with diabetic foot ulcer (DFU).

[00148] The study design was a randomized, double-blind, sham-controlled single center study. Prospective patients with diabetes attending the foot care facility at a tertiary care hospital in North India, age 18 to 60 years with foot ulcers (wound size of at least 2 cm2), Wagner Grades 2 or 3 and an ankle-brachial index (ABI) of > 0.5 were included in the study. Patients with foot ulcer of aetiologies other than diabetes, gangrene of the foot, ischemic heart disease, congestive heart failure, hepatic disease (liver enzymes >2.5 times ULN), chronic kidney diseases (eGFR<45ml/min/l.73m2), pregnant and lactating women, patients taking immunosuppressive medications like glucocorticoids, cytotoxic drugs and patients with a history of chronic alcoholism or substance abuse were excluded from the study. The study was conducted in accordance with the principles set forth in the Helsinki International Wound Declaration (7th revision amended in October 2013) and as per ICH - GCP guidelines. The study protocol was approved by the institute Ethics Committee and a written and informed consent was obtained from all the participants.

[00149] Seventy patients with neuropathic, clinically infected or non-infected DFU (wound size > 2 cm2), Wagner Grade 2 and 3 with ankle -brachial index (ABI) of >0.5 were included. Patients received ultrasound / ultrasonic therapyusing proposed method or sham therapy for 28 days dosed daily for first 6 days followed by twice a week for next 3 weeks along with standard of care for DFU including debridement, antibiotics for infected wounds, dressings and offloading. Wound size was measured during each visit and automated area calculation was performed with wound zoom camera.

[00150] The data for fifty-eight patients was finally evaluated. The duration of wound was

15.8 +/- 11.2 weeks and 12.1 +/- 10.9 weeks and wound area of 11.3 +/- 8.2 cm2 and 14.8 +/-

13.8 cm (p=0.507) in the ultrasound and sham group, respectively. A 50% reduction in wound area was observed in 39 patients with 61.5% and 38.5% subjects (p=0.042) and complete wound closure was observed in 11 subjects with 72.7% and 27.3% (p=0.033) in ultrasound and sham group, respectively. The reduction in wound area was 69.4+/- 23.2% and 59.6 +/- 24.9% (p=0.l26) in the ultrasound and sham group, respectively. The rate of wound contraction was faster in first two weeks among patients with ultrasound therapy compared to sham treatment.

[00151] As can be concluded from above, the airborne low frequency ultrasound therapy provided by proposed method improves and hastens healing of chronic neuropathic DFU when combined with standard wound care.

[00152] It should be apparent to those skilled in the art that many more modifications besides those already described are possible without departing from the inventive concepts herein. The inventive subject matter, therefore, is not to be restricted except in the spirit of the appended claims. Moreover, in interpreting both the specification and the claims, all terms should be interpreted in the broadest possible manner consistent with the context. In particular, the terms“comprises” and“comprising” should be interpreted as referring to elements, components, or steps in a non-exclusive manner, indicating that the referenced elements, components, or steps may be present, or utilized, or combined with other elements, components, or steps that are not expressly referenced. Where the specification claims refers to at least one of something selected from the group consisting of A, B, C ....and N, the text should be interpreted as requiring only one element from the group, not A plus N, or B plus N, etc. The foregoing description of the specific embodiments will so fully reveal the general nature of the embodiments herein that others can, by applying current knowledge, readily modify and/or adapt for various applications such specific embodiments without departing from the generic concept, and, therefore, such adaptations and modifications should and are intended to be comprehended within the meaning and range of equivalents of the disclosed embodiments. It is to be understood that the phraseology or terminology employed herein is for the purpose of description and not of limitation. Therefore, while the embodiments herein have been described in terms of preferred embodiments, those skilled in the art will recognize that the embodiments herein can be practiced with modification within the spirit and scope of the appended claims.

[00153] While the foregoing describes various embodiments of the invention, other and further embodiments of the invention may be devised without departing from the basic scope thereof. The scope of the invention is determined by the claims that follow. The invention is not limited to the described embodiments, versions or examples, which are included to enable a person having ordinary skill in the art to make and use the invention when combined with information and knowledge available to the person having ordinary skill in the art.

ADVANTAGES OF THE INVENTION

[00154] The present disclosure provides a method for generating non-invasive, non- contact, airborne, variable-intensity multi-beam and multi-directional energy wavefront comprising any or a combination of ultrasonic waves and sonic waves.

[00155] The present disclosure provides a method for generating a multi-beam and multi directional energy wavefront having multiple resonant frequencies spanning over various sonic and ultrasonic ranges to have a wide band response to target different diseases and organs with specific frequency and intensity.

[00156] The present disclosure provides a method for generating a multi-beam and multi directional energy wavefront to obtain multi-beam and multi-directional wavefront with variable amplitude/intensity.

[00157] The present disclosure provides a method for generating, shaping as well as scattering a primary wavefront generated by a piezoelectric crystal.

[00158] The present disclosure provides a method for generating non-invasive, non- contact, airborne, variable-intensity, multi-frequency, multi-beam and multi-directional energy wavefront that creates a vibrational environment to stimulate cells of human body into a nascent state using the energy waves generated thereof.

Claims

We Claim:
1. A method for generating an energy wavefront, said method comprising:
receiving, at a transducer device, a combined ultrasonic and sonic waveform signal;
creating a combined ultrasonic and sonic wave based on said combined ultrasonic and sonic waveform signal, using the transducer device;
creating a primary standing wave between the transducer device and a first resonator device, wherein said first resonator device is located on one side of the transducer device and the primary standing wave is created due to interaction or resonance between the combined ultrasonic and sonic wave and a reflection of the combined ultrasonic and sonic wave from the first resonator device;
creating a secondary standing wave between the transducer device and a second resonator plate located on an other side of the transducer device, wherein the second resonator plate is placed towards the center of a grill and wherein the secondary standing wave is created due to the interaction or resonance between the combined ultrasonic and sonic wave and a reflection of the combined ultrasonic and sonic wave from the second resonator plate; and
using a parabolic reflector to shape, reflect and transmit the energy wavefront, wherein the energy wavefront includes wave elements of one or more of the combined ultrasonic and sonic wave, the primary standing wave and the secondary standing wave.
2. The method as claimed in claim 1, wherein said wave elements include one or more of the following:
parts of,
combinations of,
reflections of,
deflections of,
interferences of,
resonances of,
cross-talk between,
attenuations of, and
modifications of one or more of the combined ultrasonic and sonic wave, the primary standing wave and the secondary standing wave.
3. The method as claimed in claim 1, wherein said transducer device is any or a combination of a piezoelectric crystal positioned on a substrate such that said piezoelectric crystal has a dead zone towards its center and said combined ultrasonic and sonic wave that it creates has a hollow cylindrical shape, and a device that converts a combined ultrasonic and sonic waveform signal into a combined ultrasonic and sonic wave having a hollow cylindrical shape.
4. The method as claimed in claim 1, wherein said first resonator device is a cavity resonator, wherein said cavity resonator comprises a hollow cylinder with one end placed on one side of the transducer device and the other end having a first resonator plate.
5. The method as claimed in claim 1, wherein the parabolic reflector is placed at the periphery of and surrounds the transducer device and first resonator device, such that the transducer device and first resonator device are at focal point area of the parabolic reflector.
6. The method as claimed in claim 1, wherein the grill is positioned facing and in close proximity to the parabolic reflector such that the second resonator plate is in front of the other side of the transducer device.
7. The method as claimed in claim 1, wherein the combined ultrasonic and sonic wave has a hollow cylindrical shape.
8. The method as claimed in claim 1, wherein the energy wavefront is in the form of a donut shaped toroidal wavefront.
9. The method as claimed in claim 1, wherein the energy wavefront is scattered by the grill to make it multi-beam and multi-directional.
10. The method as claimed in claim 1, wherein the interaction or resonance between the combined ultrasonic and sonic wave and the reflection induces necessary attenuation and tuning of the primary standing wave.
11. The method as claimed in claim 1, wherein the combined ultrasonic and sonic waveform signal is created by combining a sonic wave signal and ultrasonic wave signal, and wherein the combined ultrasonic and sonic waveform signal comprises the sonic wave signal encapsulated in the ultrasonic wave signal or vice versa.
12. The method of claim 1, wherein the amplitude of said primary standing wave is modulated.
13. The method of claim 1, where the method further comprises any or a combination of:
modulating amplitude of said combined ultrasonic and sonic wave;
modulating amplitude of said primary standing wave;
modulating parabolic spin angle of said energy wavefront;
blocking any or a combination of said combined ultrasonic and sonic wave and said primary and secondary standing waves; and
slicing off said combined ultrasonic and sonic wave at appropriate angles using said grill.
14. The method as claimed in claim 1, wherein said parabolic reflector comprises a cavity surrounded by a tapered surface, said tapered surface bound by a taper angle of about 30 to 50 degrees with a longitudinal surface of said parabolic reflector.
15. The method as claimed in claim 1, wherein thickness of said grill ranges from about 1.5 mm to 4 mm, and wherein said grill has slots extending up to a thickness of about 3 mm, and wherein said grill is in form of a disc of diameter from about 18.05 mm to about 45 mm.
16. The method as claimed in claim 3, wherein said piezoelectric crystal comprises a metal substrate disc of diameter from about 27 mm to 40 mm that surrounds a crystal compound disc of diameter from about 20 mm to 30mm, said crystal compound disc in turn surrounding a dead zone region of diameter from about 6.5 mm to 15 mm, and wherein said metal substrate disc has a thickness from about 0.25 mm to about 0.5 mm.
17. The method as claimed in claim 4, wherein diameter of said cavity resonator ranges from about 30 millimeter (mm) to about 40 mm, and is adjusted to change amplitude of the primary standing wave, and wherein height of said cavity resonator ranges from about 5 mm to about 15 mm and is adjusted to modulate primary transmission beam angle of said combined ultrasonic and sonic wave.
18. The method of claim 11, wherein said sonic wave signal is created with frequency range between 1.5 Hz and 620Hz, and said ultrasonic wave signal is created with frequency range between 20 KHz and lOOKHz.
19. The method of claim 11, wherein there is variation in frequency of any or a combination of the sonic wave signal, the ultrasonic wave signal, and the combined ultrasonic and sonic waveform signal such that the variation in the frequency is in an increasing sweep or a decreasing sweep or both.
20. The method of claim 19, wherein the energy wavefront comprises a multi-directional low frequency ultrasonic carrier sweep with an encapsulated multi-directional sonic frequency sweep having frequency ranges that cover natural resonant frequency range of human body as a whole as well as at cellular level.
21. The method of claim 21, wherein the energy wavefront is configured to engulf a person from all directions, and wherein the energy wavefront creates a vibrational environment to stimulate cells of human body into a nascent state.
22. The method of claim 21, wherein exposure of a person to said energy wavefront enables, for the person, any or a combination of:
stimulation of cell metabolism, targeted tissue repair, diabetic foot ulcer, Venus ulcer, organ re-vitalization and enhancement of drug delivery and efficiency, modification of cell membrane permeability leading to different rates of transports of ions and molecules across the cell membrane,
increase in potassium ion influx together with increase in sodium efflux without inducing cell lysis or gross membrane damage, and
enhancement in intracellular concentration of calcium ions, tissue permeability, cell membrane permeability, calcium influx and release of insulin from pancreatic beta cells.
23. The method of claim 21, wherein exposure of a person to said energy wavefront leads to, for the person, any or more of:
generation of microbubbles in water and lipid bilayers of skin,
improvement in the action potential of drugs,
improvement in glycemic control,
improvement in histological, pathological, biochemical and biomedical parameters of the person’s body,
inducement of remedial natural disease-free health,
increase in vitamin D and calcium levels,
reduction in Alpha Glucosydase levels,
assistance in drug delivery of large molecule such as B6/B12 and absorption of the same,
effective regulation of Homocystein Metabolism, and
improvement in immunity profile.
PCT/IB2019/051924 2018-03-24 2019-03-09 Method to generate an energy wavefront WO2019186304A1 (en)

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Citations (3)

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Publication number Priority date Publication date Assignee Title
US4379998A (en) * 1981-06-25 1983-04-12 The Standard Oil Company Acoustic degenerate four-wave mixing phase-conjugate reflector
US5889870A (en) * 1996-07-17 1999-03-30 American Technology Corporation Acoustic heterodyne device and method
US7443573B2 (en) * 2005-09-20 2008-10-28 Raytheon Company Spatially-fed high-power amplifier with shaped reflectors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4379998A (en) * 1981-06-25 1983-04-12 The Standard Oil Company Acoustic degenerate four-wave mixing phase-conjugate reflector
US5889870A (en) * 1996-07-17 1999-03-30 American Technology Corporation Acoustic heterodyne device and method
US7443573B2 (en) * 2005-09-20 2008-10-28 Raytheon Company Spatially-fed high-power amplifier with shaped reflectors

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