WO2019079830A1 - High-current conduction cooled superconducting radio-frequency cryomodule - Google Patents
High-current conduction cooled superconducting radio-frequency cryomodule Download PDFInfo
- Publication number
- WO2019079830A1 WO2019079830A1 PCT/US2018/062016 US2018062016W WO2019079830A1 WO 2019079830 A1 WO2019079830 A1 WO 2019079830A1 US 2018062016 W US2018062016 W US 2018062016W WO 2019079830 A1 WO2019079830 A1 WO 2019079830A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- srf
- cryomodule
- cavity
- beam tube
- cold head
- Prior art date
Links
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229910052802 copper Inorganic materials 0.000 claims abstract description 12
- 239000010949 copper Substances 0.000 claims abstract description 12
- 239000010955 niobium Substances 0.000 claims abstract description 8
- 239000011248 coating agent Substances 0.000 claims abstract description 6
- 238000000576 coating method Methods 0.000 claims abstract description 6
- 238000013016 damping Methods 0.000 claims abstract description 6
- 238000001816 cooling Methods 0.000 claims abstract description 5
- 229910000657 niobium-tin Inorganic materials 0.000 claims abstract description 5
- 229910052758 niobium Inorganic materials 0.000 claims abstract description 4
- GUCVJGMIXFAOAE-UHFFFAOYSA-N niobium atom Chemical compound [Nb] GUCVJGMIXFAOAE-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229910000859 α-Fe Inorganic materials 0.000 claims abstract description 3
- 238000010894 electron beam technology Methods 0.000 claims abstract 6
- 239000002887 superconductor Substances 0.000 claims description 8
- 229910052751 metal Inorganic materials 0.000 claims description 6
- 239000002184 metal Substances 0.000 claims description 6
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims description 6
- 229910052721 tungsten Inorganic materials 0.000 claims description 6
- 239000010937 tungsten Substances 0.000 claims description 6
- 239000004020 conductor Substances 0.000 claims description 5
- 238000009501 film coating Methods 0.000 claims description 5
- 239000010409 thin film Substances 0.000 claims description 5
- 238000005229 chemical vapour deposition Methods 0.000 claims description 4
- 238000009713 electroplating Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 238000004549 pulsed laser deposition Methods 0.000 claims description 4
- 238000010290 vacuum plasma spraying Methods 0.000 claims description 4
- 229910019794 NbN Inorganic materials 0.000 claims description 2
- 229910000750 Niobium-germanium Inorganic materials 0.000 claims description 2
- 230000004907 flux Effects 0.000 claims description 2
- 230000002452 interceptive effect Effects 0.000 claims description 2
- 230000035699 permeability Effects 0.000 claims description 2
- 239000006096 absorbing agent Substances 0.000 claims 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 abstract description 6
- 239000010410 layer Substances 0.000 description 11
- 238000005516 engineering process Methods 0.000 description 4
- 230000007613 environmental effect Effects 0.000 description 3
- 239000003546 flue gas Substances 0.000 description 3
- 239000001307 helium Substances 0.000 description 3
- 229910052734 helium Inorganic materials 0.000 description 3
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000005067 remediation Methods 0.000 description 3
- 229910052738 indium Inorganic materials 0.000 description 2
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 239000011229 interlayer Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 239000002351 wastewater Substances 0.000 description 2
- 229910021521 yttrium barium copper oxide Inorganic materials 0.000 description 2
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical class [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 1
- BTGZYWWSOPEHMM-UHFFFAOYSA-N [O].[Cu].[Y].[Ba] Chemical compound [O].[Cu].[Y].[Ba] BTGZYWWSOPEHMM-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910001092 metal group alloy Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000010802 sludge Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H7/00—Details of devices of the types covered by groups H05H9/00, H05H11/00, H05H13/00
- H05H7/14—Vacuum chambers
- H05H7/18—Cavities; Resonators
- H05H7/20—Cavities; Resonators with superconductive walls
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C3/00—Vessels not under pressure
- F17C3/02—Vessels not under pressure with provision for thermal insulation
- F17C3/08—Vessels not under pressure with provision for thermal insulation by vacuum spaces, e.g. Dewar flask
- F17C3/085—Cryostats
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H7/00—Details of devices of the types covered by groups H05H9/00, H05H11/00, H05H13/00
- H05H7/02—Circuits or systems for supplying or feeding radio-frequency energy
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H9/00—Linear accelerators
- H05H9/04—Standing-wave linear accelerators
- H05H9/048—Lepton LINACS
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H7/00—Details of devices of the types covered by groups H05H9/00, H05H11/00, H05H13/00
- H05H7/02—Circuits or systems for supplying or feeding radio-frequency energy
- H05H2007/025—Radiofrequency systems
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H7/00—Details of devices of the types covered by groups H05H9/00, H05H11/00, H05H13/00
- H05H7/22—Details of linear accelerators, e.g. drift tubes
- H05H2007/227—Details of linear accelerators, e.g. drift tubes power coupling, e.g. coupling loops
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H2242/00—Auxiliary systems
- H05H2242/10—Cooling arrangements
Definitions
- the present invention relates to superconducting radio-frequency (SRF) cryomodules used in particle accelerators, and in particular to a compact, conduction-cooled SRF cryomodule suitable to accelerate a high-current beam.
- SRF radio-frequency
- SRF Radio-Frequency
- CW continuous-wave
- the superconducting state is achieved by cooling niobium SRF cavities, the accelerating structures inside the cryomodule, to below the transition temperature of 9.2K, typically to 4.3 K or lower, by means of immersing them in a liquid helium (He) bath.
- He liquid helium
- Cryogenic plants required to supply the liquid helium to SRF cryomodules are complex, of substantial size, constitute a major fraction of the capital and operating cost of SRF accelerators, and are one of the main obstacles towards a more widespread use of SRF technology.
- SRF technology is applicable to many industrial applications, such as environmental remediation, the high cost of producing and operating the cryogenic plant substantially limits the application of SRF technology.
- An object of this invention is to provide a compact, conduction cooled, high-current SRF cryomodule for use in particle accelerators for industrial applications.
- a further object is to provide an SRF cryomodule that greatly reduces the capital cost, operating cost, and operational complexity of a cryomodule for use in a particle accelerator.
- a further object is to provide an SRF cryomodule that eliminates the need for a helium liquefier, a pressure vessel, and a cold tuner.
- Another object is to significantly lower investment and operating costs of an SRF accelerator.
- a further object is to provide an SRF cryomodule that is free of liquid cryogen hazards.
- Another object of the invention is to provide an SRF cryomodule in which the conventional cryogenic plant is replaced by a closed-cycle refrigerator at much lower cost.
- a still further object of the invention is to provide a compact, conduction-cooled SRF cryomodule capable of accelerating a high-current beam operating at a current of 1 ampere or greater and at an energy of 1-10 MeV.
- a still further object of the invention is to provide a high current SRF cryomodule that can be used for cleaning flue gases, such as converting nitrous oxides in the flue gases, or for treating wastewater streams, such as hospital or municipal waste streams, to remove biological materials, or to modify the sludge in waste treatment plants.
- the present invention is a compact, conduction-cooled, high-current SRF cryomodule for particle accelerators.
- the cryomodule includes a multi-layer SRF cavity, dual coaxial input couplers, high-order modes (HOM) dampers, thermal shield, magnetic shields, support structure, a vacuum vessel and multiple cryocoolers.
- HOM high-order modes
- the cryogenic plant is replaced by commercial Gifford-McMahon (GM) closed-cycle refrigerators at much lower cost.
- GM Gifford-McMahon
- FIG. 1 is a perspective view of a cryomodule vacuum vessel that houses a conduction- cooled, high-current SRF cryomodule according to the present invention.
- Fig. 2 is a sectional view of the SRF cavity taken along line 2-2 of Fig. 1.
- Fig. 3 is a sectional view of an SRF cavity that forms a portion of the SRF cryomodule according to the present invention.
- Fig. 4 is a is a sectional view of the SRF cryomodule taken along line 4-4 of Fig. 1.
- Fig. 5 is a is a sectional view of the power coupler taken along line 5-5 of Fig. 4.
- the invention is a compact, conduction cooled SRF cryomodule 10 for accelerating a high current beam.
- high current beam refers to a beam that includes a current of up to or greater than 1 ampere.
- compact refers to a conduction cooled SRF cryomodule that has an overall size of 1.5 m by 1.5 m or less.
- the conduction cooled SRF cryomodule 10 includes an SRF cavity 12 located inside a vacuum vessel 14.
- Figure 2 depicts a single-cell cavity although other arrangements such as multiple-cell cavities are within the scope of the invention.
- the SRF cavity 12 is preferably of elliptical shape and geometric ⁇ tailored to the energy of the incoming beam.
- the SRF cavity 12 is preferably fabricated from high-purity niobium (Nb) having a residual resistivity ratio of greater than 300 and includes a thickness of 3 - 5 millimeters.
- metals with thermal conductivity greater than 500 W/(m K) at 4 K, such as tungsten or copper, could also be used.
- the cavity inner surface 16 is coated with a thin (1-1.5 ⁇ thick) superconducting inner layer 18 preferably formed by thermal diffusion of Sn vapor in a vacuum furnace at 1000 - 1200 °C.
- the inner layer 18 is preferably constructed of Nb 3 Sn, Nb 3 Ge, NbN, or NbTiN, and is most preferably constructed of Nb 3 Sn.
- the thin film coating is a
- the SRF cavity 12 outer surface 20 is coated with a layer 22 preferably of copper or tungsten, and most preferably of pure copper having a purity of greater than 99.98%.
- the method of applying the outer layer 22 is preferably by electroplating, vacuum plasma spraying, or by a combination of vacuum plasma-spraying and electroplating.
- the outer coating is not required if the cavity is fabricated from a metal other than Nb.
- two symmetrically located coaxial power couplers 24 are used to feed RF power into the SRF cavity 12.
- Each power coupler 24 is capable of sustaining a minimum of 500 kW of RF power into the SRF cavity 12.
- a section of the inner surface of the outer conductor of the power coupler is preferably coated with a thin layer 25 (1-1.5 ⁇ thick) of a high-temperature superconductor to minimize the static and dynamic heat load from the coupler.
- the thin layer 25 of high-temperature superconductor material is YBCO (yttrium barium copper oxide) having a critical temperature greater than 90 K.
- the high-temperature superconductor is preferably applied to the inner surface of the outer conductor by methods including physical-chemical vapor deposition, pulsed laser deposition, or a combination of physical-chemical vapor deposition and pulsed laser deposition.
- cryocoolers 26 each include a first stage cold head 28 and a second stage cold head 30.
- the second stage cold head 30 of each cryocooler is connected to the SRF cavity 12 by means of a mechanical contact joint 32 with a malleable indium interlayer 34 and a high thermal conductivity strain relief section 36.
- the outer copper layer 20 (see Fig. 3) of the SRF cavity 12 will provide a high thermal conduction path from the SRF cavity surfaces to the cryocooler second stage cold heads 30.
- the first stage cold head 28 of the cryocooler is preferably at a temperature of 50 - 80 K and the second stage cold head 30 of the cryocooler is preferably at a temperature of 4.3 - 9 K
- a preferred cryocooler such as described herein is the Gifford-McMahon (GM) type cryocooler, available from Sumitomo (SHI) Cryogenics of America, in Allentown, Pennsylvania. Most preferably, the cryocooler 26 would have a second stage capacity greater than or equal to 1.5 watts W at 4.2 K.
- a preferred strain relief section is preferably constructed of copper or tungsten and most preferably consists of copper thermal straps such as those available from Technology Applications, Inc., in Boulder, Colorado.
- the conduction cooled SRF cryomodule 10 preferably includes a thermal shield 38 with a structure core 40, wherein said structure core is connected to the cryocooler first stage cold heads 28 by means of a mechanical contact joint with a malleable indium interlayer.
- High thermal conductivity strain relief sections are located along the shield structure core 40.
- Thermal shield 38 preferably constructed of oxygen-free electronic copper, takes infrared heat away from the SRF cavity. Multi-layer insulation blankets are wrapped around the thermal shield to further reduce radiative heat transfer.
- Magnetic fields are preferably minimized in the SRF cavity 12 through the use of an inner magnetic shield 42 and an outer magnetic shield 44.
- the magnetic shields are preferably constructed of a material with the ability to support the absorption of a magnetic field within itself.
- the magnetic shields are constructed of a shielding alloy that will attract magnetic flux lines of the interfering fields to itself and divert the unwanted field away from sensitive areas or components.
- the magnetic shields are preferably constructed of a high permeability metal having high magnetic shielding properties.
- the magnetic shields are most preferably constructed of MuMETAL®, a metal alloy available from Magnetic Shield
- multi-layer insulation blankets are wrapped around the inner magnetic shield.
- the conduction cooled SRF cryomodule 10 preferably includes an entrance beam tube 46 and an exit beam tube 48 connected to the SRF cavity 12. Most preferably, damping of the high-order modes of the accelerated particles is achieved by enlarging the exit beam tube 48 of the SRF cavity. As shown in Fig. 2, the diameter of the exit beam tube 48 is larger than the diameter of the entrance beam tube 46.
- the SRF cryomodule includes a water-cooled beam pipe higher-order mode ferrite damper 50 for damping of higher-order modes and allowing their propagation to a room-temperature..
- a conduction cooled SRF cryomodule 10 with 1 MW RF power fed into the SRF cavity by the power couplers 24 is capable of generating a 1 ampere beam (high current SRF beam) at 1 MW RF power.
- the volume within the cavity is isolated from the outside environment by means of two vacuum valves 52 outside the vacuum vessel, which are preferably all-metal gate valves.
- a vacuum valve 52 is included on the entrance 46 and on the exit beam tube 48.
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- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Plasma & Fusion (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Thermal Sciences (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Particle Accelerators (AREA)
- Containers, Films, And Cooling For Superconductive Devices (AREA)
- Shielding Devices Or Components To Electric Or Magnetic Fields (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2020114520A RU2020114520A (en) | 2017-09-26 | 2018-11-20 | HIGH CURRENT COOLED BY THERMAL CONDUCTIVITY SUPERCONDUCTING RADIO FREQUENCY CRYOMODULE |
EP18869450.9A EP3747242A4 (en) | 2017-09-26 | 2018-11-20 | High-current conduction cooled superconducting radio-frequency cryomodule |
CA3075823A CA3075823C (en) | 2017-09-26 | 2018-11-20 | High-current conduction cooled superconducting radio-frequency cryomodule |
JP2020538777A JP7094373B2 (en) | 2017-09-26 | 2018-11-20 | High Current Conduction Cooling Superconducting High Frequency Cryomodule |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762563274P | 2017-09-26 | 2017-09-26 | |
US62/563,274 | 2017-09-26 | ||
US15/882,211 US10932355B2 (en) | 2017-09-26 | 2018-01-29 | High-current conduction cooled superconducting radio-frequency cryomodule |
US15/882,211 | 2018-01-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2019079830A1 true WO2019079830A1 (en) | 2019-04-25 |
WO2019079830A4 WO2019079830A4 (en) | 2019-06-27 |
Family
ID=65808204
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2018/062016 WO2019079830A1 (en) | 2017-09-26 | 2018-11-20 | High-current conduction cooled superconducting radio-frequency cryomodule |
Country Status (6)
Country | Link |
---|---|
US (1) | US10932355B2 (en) |
EP (1) | EP3747242A4 (en) |
JP (1) | JP7094373B2 (en) |
CA (1) | CA3075823C (en) |
RU (1) | RU2020114520A (en) |
WO (1) | WO2019079830A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102020127132A1 (en) | 2020-10-15 | 2022-04-21 | Helmholtz-Zentrum Berlin für Materialien und Energie Gesellschaft mit beschränkter Haftung | HOM-damped superconducting cavity resonator, use of the same and method for its production |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11483920B2 (en) * | 2019-12-13 | 2022-10-25 | Jefferson Science Associates, Llc | High efficiency normal conducting linac for environmental water remediation |
CN113373404B (en) * | 2021-06-10 | 2022-09-27 | 中国科学院近代物理研究所 | Copper-based thick-wall Nb 3 Sn film superconducting cavity and preparation method thereof |
CN113593768B (en) * | 2021-08-05 | 2022-11-01 | 中国科学院近代物理研究所 | Superconducting cavity solid conduction cooling structure |
CN113811065B (en) * | 2021-09-16 | 2023-07-25 | 中国科学院近代物理研究所 | Double-electrode direct current structure for locally heating tin source in superconducting cavity |
JP2024021776A (en) * | 2022-08-04 | 2024-02-16 | 三菱重工機械システム株式会社 | Superconduction cryo-module |
CN115852356B (en) * | 2022-12-22 | 2024-10-18 | 中国科学院近代物理研究所 | Material adding method for high-heat-conductivity copper layer on outer surface of niobium three-tin film superconducting cavity |
CN118175719A (en) * | 2024-03-14 | 2024-06-11 | 北京大学 | Conduction cooling type DC-SRF electron gun |
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2018
- 2018-01-29 US US15/882,211 patent/US10932355B2/en active Active
- 2018-11-20 JP JP2020538777A patent/JP7094373B2/en active Active
- 2018-11-20 EP EP18869450.9A patent/EP3747242A4/en not_active Withdrawn
- 2018-11-20 RU RU2020114520A patent/RU2020114520A/en unknown
- 2018-11-20 CA CA3075823A patent/CA3075823C/en active Active
- 2018-11-20 WO PCT/US2018/062016 patent/WO2019079830A1/en unknown
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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DE102020127132A1 (en) | 2020-10-15 | 2022-04-21 | Helmholtz-Zentrum Berlin für Materialien und Energie Gesellschaft mit beschränkter Haftung | HOM-damped superconducting cavity resonator, use of the same and method for its production |
DE102020127132B4 (en) | 2020-10-15 | 2023-03-30 | Helmholtz-Zentrum Berlin für Materialien und Energie Gesellschaft mit beschränkter Haftung | HOM-damped superconducting cavity resonator, use of the same and method for its production |
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JP7094373B2 (en) | 2022-07-01 |
WO2019079830A4 (en) | 2019-06-27 |
US20190098741A1 (en) | 2019-03-28 |
CA3075823A1 (en) | 2019-04-25 |
EP3747242A4 (en) | 2021-08-11 |
RU2020114520A (en) | 2021-10-27 |
EP3747242A1 (en) | 2020-12-09 |
US10932355B2 (en) | 2021-02-23 |
CA3075823C (en) | 2022-06-07 |
JP2021507544A (en) | 2021-02-22 |
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