WO2018224506A3 - Diagnostic auto-immun à l'aide de populations de lymphocytes t - Google Patents
Diagnostic auto-immun à l'aide de populations de lymphocytes t Download PDFInfo
- Publication number
- WO2018224506A3 WO2018224506A3 PCT/EP2018/064789 EP2018064789W WO2018224506A3 WO 2018224506 A3 WO2018224506 A3 WO 2018224506A3 EP 2018064789 W EP2018064789 W EP 2018064789W WO 2018224506 A3 WO2018224506 A3 WO 2018224506A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cell populations
- auto immune
- immune diagnosis
- diagnosis
- diagnosing
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
L'invention concerne le diagnostic de troubles auto-immuns, et concerne des méthodes, des utilisations, des produits, des biomarqueurs et des kits permettant de diagnostiquer, d'identifier ou de stratifier des patients atteints d'un trouble auto-immun. En particulier, l'invention concerne un kit, un produit, un biomarqueur, une utilisation ou une méthode permettant de diagnostiquer ou de stratifier le syndrome de Sjögren.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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PT110129 | 2017-06-06 | ||
PT11012917 | 2017-06-06 |
Publications (2)
Publication Number | Publication Date |
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WO2018224506A2 WO2018224506A2 (fr) | 2018-12-13 |
WO2018224506A3 true WO2018224506A3 (fr) | 2019-01-17 |
Family
ID=62748905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2018/064789 WO2018224506A2 (fr) | 2017-06-06 | 2018-06-05 | Diagnostic auto-immun à l'aide de populations de lymphocytes t |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2018224506A2 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB202009148D0 (en) * | 2020-06-16 | 2020-07-29 | Ucl Business Ltd | Method |
GB202109179D0 (en) * | 2021-06-25 | 2021-08-11 | Univ Ulster | A cell based test to monitor DMARD drug response |
CN113552347A (zh) * | 2021-07-16 | 2021-10-26 | 华中科技大学同济医学院附属同济医院 | 检测滤泡调节性t细胞试剂在制备变应性鼻炎免疫治疗预后诊断试剂中的应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US20170108514A1 (en) * | 2014-03-23 | 2017-04-20 | The Regents Of The University Of Colorado, A Body Corporate | Diagnosis of multiple sclerosis in human and animal subjects |
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2018
- 2018-06-05 WO PCT/EP2018/064789 patent/WO2018224506A2/fr active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US20170108514A1 (en) * | 2014-03-23 | 2017-04-20 | The Regents Of The University Of Colorado, A Body Corporate | Diagnosis of multiple sclerosis in human and animal subjects |
Non-Patent Citations (13)
Title |
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ANA RAQUEL MACEIRAS ET AL: "T follicular helper and T follicular regulatory cells have different TCR specificity", NATURE COMMUNICATIONS, vol. 8, 21 April 2017 (2017-04-21), pages 15067, XP055498035, DOI: 10.1038/ncomms15067 * |
ANA RAQUEL MACEIRAS ET AL: "T follicular regulatory cells in mice and men", IMMUNOLOGY, vol. 152, no. 1, 27 July 2017 (2017-07-27), GB, pages 25 - 35, XP055498098, ISSN: 0019-2805, DOI: 10.1111/imm.12774 * |
CINDY S MA ET AL: "Human T follicular helper (Tfh) cells and disease", IMMUNOLOGY AND CELL BIOLOGY, vol. 92, no. 1, 22 October 2013 (2013-10-22), AU, pages 64 - 71, XP055318710, ISSN: 0818-9641, DOI: 10.1038/icb.2013.55 * |
DEEPAK A. RAO ET AL: "Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis", NATURE, vol. 542, no. 7639, 1 February 2017 (2017-02-01), GB, pages 110 - 114, XP055498123, ISSN: 0028-0836, DOI: 10.1038/nature20810 * |
DIANA GOMEZ-MARTIN ET AL: "Follicular helper T cells poise immune responses to the development of autoimmune pathology", AUTOIMMUNITY REVIEWS, ELSEVIER, AMSTERDAM, NL, vol. 10, no. 6, 6 November 2010 (2010-11-06), pages 325 - 330, XP028159585, ISSN: 1568-9972, [retrieved on 20101215], DOI: 10.1016/J.AUTREV.2010.11.007 * |
PETER T. SAGE ET AL: "T follicular regulatory cells in the regulation of B cell responses", TRENDS IN IMMUNOLOGY, vol. 36, no. 7, 1 July 2015 (2015-07-01), GB, pages 410 - 418, XP055386876, ISSN: 1471-4906, DOI: 10.1016/j.it.2015.05.005 * |
SZABO KRISZTINA ET AL: "Follicular helper T cells may play an important role in the severity of primary Sjögren's syndrome", CLINICAL IMMUNOLOGY, ACADEMIC PRESS, US, vol. 147, no. 2, 15 March 2013 (2013-03-15), pages 95 - 104, XP028581844, ISSN: 1521-6616, DOI: 10.1016/J.CLIM.2013.02.024 * |
TESSA DHAEZE ET AL: "Circulating Follicular Regulatory T Cells Are Defective in Multiple Sclerosis", THE JOURNAL OF IMMUNOLOGY, vol. 195, no. 3, 12 June 2015 (2015-06-12), US, pages 832 - 840, XP055498224, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1500759 * |
UENO HIDEKI: "Human Circulating T Follicular Helper Cell Subsets in Health and Disease", JOURNAL OF CLINICAL IMMUNOLOGY, KLUWER ACADEMIC PUBLISHERS, NEW YORK, vol. 36, no. 1, 17 March 2016 (2016-03-17), pages 34 - 39, XP035916780, ISSN: 0271-9142, [retrieved on 20160317], DOI: 10.1007/S10875-016-0268-3 * |
VALTER R. FONSECA ET AL: "The Ratio of Blood T Follicular Regulatory Cells to T Follicular Helper Cells Marks Ectopic Lymphoid Structure Formation While Activated Follicular Helper T Cells Indicate Disease Activity in Primary Sjögren's Syndrome", ARTHRITIS & RHEUMATOLOGY (HOBOKEN), vol. 70, no. 5, 25 March 2018 (2018-03-25), US, pages 774 - 784, XP055498089, ISSN: 2326-5191, DOI: 10.1002/art.40424 * |
XIE XIAOLI ET AL: "ATRA alters humoral responses associated with amelioration of EAMG symptoms by balancing Tfh/Tfr helper cell profiles", CLINICAL IMMUNOLOGY, vol. 148, no. 2, 24 May 2013 (2013-05-24), pages 162 - 176, XP028674567, ISSN: 1521-6616, DOI: 10.1016/J.CLIM.2013.05.009 * |
YANBIN WEN ET AL: "Imbalance of circulating CD4 + CXCR5 + FOXP3 + Tfr-like cells and CD4 + CXCR5 + FOXP3 - Tfh-like cells in myasthenia gravis", NEUROSCIENCE LETTERS, vol. 630, 1 September 2016 (2016-09-01), AMSTERDAM, NL, pages 176 - 182, XP055498226, ISSN: 0304-3940, DOI: 10.1016/j.neulet.2016.07.049 * |
YOUNG UK KIM ET AL: "Regulation of Autoimmune Germinal Center Reactions in Lupus-Prone BXD2 Mice by Follicular Helper T Cells", PLOS ONE, vol. 10, no. 3, 13 March 2015 (2015-03-13), pages e0120294, XP055498737, DOI: 10.1371/journal.pone.0120294 * |
Also Published As
Publication number | Publication date |
---|---|
WO2018224506A2 (fr) | 2018-12-13 |
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