WO2018188105A1 - 一种用于磁共振测试的软组织模拟器及模拟测试方法 - Google Patents

一种用于磁共振测试的软组织模拟器及模拟测试方法 Download PDF

Info

Publication number
WO2018188105A1
WO2018188105A1 PCT/CN2017/080849 CN2017080849W WO2018188105A1 WO 2018188105 A1 WO2018188105 A1 WO 2018188105A1 CN 2017080849 W CN2017080849 W CN 2017080849W WO 2018188105 A1 WO2018188105 A1 WO 2018188105A1
Authority
WO
WIPO (PCT)
Prior art keywords
soft tissue
sample
magnetic resonance
reversing valve
chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2017/080849
Other languages
English (en)
French (fr)
Inventor
冯原
胡春洪
赵雪峰
朱默
黄珑
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suzhou University
Original Assignee
Suzhou University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suzhou University filed Critical Suzhou University
Priority to US15/769,333 priority Critical patent/US10859660B2/en
Publication of WO2018188105A1 publication Critical patent/WO2018188105A1/zh
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/58—Calibration of imaging systems, e.g. using test probes, Phantoms; Calibration objects or fiducial markers such as active or passive RF coils surrounding an MR active material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
    • G01N3/32—Investigating strength properties of solid materials by application of mechanical stress by applying repeated or pulsating forces
    • G01N3/36—Investigating strength properties of solid materials by application of mechanical stress by applying repeated or pulsating forces generated by pneumatic or hydraulic means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/30—Assessment of water resources

Definitions

  • the invention relates to the field of soft materials and experimental mechanics, in particular to a soft tissue simulator and a simulation test method for magnetic resonance testing.
  • Magnetic resonance-based soft tissue physical property testing is an important development direction based on imaging clinical diagnosis.
  • the main methods for testing physical properties of human soft tissue based on magnetic resonance are mark imaging technology and elastic imaging technology.
  • the application of animal and artificial samples for simulation testing is the main means for new measurement methods and disease detection applications before clinical application.
  • the driving method of applying displacement is mainly film driving and piezoelectric ceramic driving.
  • the film is driven by the method: the driving film is coated on the outside of the airbag, and the film is pneumatically applied to the sample.
  • the disadvantage is that it is difficult to perform the simulation and test of the marking imaging, and the driving displacement distribution is difficult to control; the driving is performed by the piezoelectric ceramic: The mechanical connection method transmits the displacement generated by the piezoelectric actuator to the output end.
  • the disadvantage is that it is difficult to perform simulation test on large samples, and the range of displacement amplitude adjustment is limited, which makes it difficult to perform simulation and test of mark imaging.
  • the driving displacement range is limited, can not face a variety of different displacement ranges of different imaging methods;
  • the displacement of the piezoelectric drive is small, and it is difficult to apply a large sample for measurement.
  • an object of the present invention is to provide a soft tissue simulator and a simulation test method for magnetic resonance testing, which have a large range of driving displacement amplitude, can drive and uniformly distribute displacements of samples of different sizes, and control It has good precision and is commonly used for simulation of soft tissue physical property measurement based on magnetic resonance method.
  • the soft tissue simulator for magnetic resonance test of the present invention comprises a base for carrying a soft tissue sample, a head facing the sample, a gas cylinder for driving the head to reciprocate relative to the sample, and a gas source for supplying gas to the gas cylinder, wherein the gas cylinder is The piston is divided into a first chamber and a second chamber, the piston is connected to the pressure head; the gas source comprises a pneumatic generating source, and a first air outlet and a second air outlet connected to the pneumatic generating source To the valve, the first air outlet and the second air outlet of the reversing valve are respectively in communication with the first chamber and the second chamber of the air cylinder.
  • the base is provided with an adjusting device for adjusting a spacing between the air cylinder and the sample
  • the adjusting device includes two screw rods rotatably connected to the base at one end, and two ends respectively and two screw threads
  • the connected slide table the top plate rotatably connected to the other end of the two screw rods, and a knob disposed on the top plate for driving the rotation of the two screw rods, the air cylinder is disposed on the slide table.
  • both ends of the screw rod are respectively rotatably connected to the base and the top plate through bearings.
  • a one-way throttle valve is connected between the pneumatic generating source and the reversing valve.
  • the reversing valve is a two-position five-way electromagnetic reversing valve.
  • the pneumatic generating source is an air compressor that generates compressed air.
  • the method of the present invention for performing simulation test using the soft tissue simulator for magnetic resonance test described above Law including steps:
  • the present invention has at least the following advantages:
  • the reversing valve is used to control the compressed air to uniformly enter the first chamber or the second chamber of the air cylinder to control the movement of the pressure head, the displacement distribution is uniform, and the control precision is good;
  • the displacement between the gas cylinder and the base can be adjusted according to the size of the sample, the range of driving displacement is large, and the displacement amplitude can be controlled and adjusted;
  • FIG. 1 is a schematic structural view of a soft tissue simulator for magnetic resonance testing of the present invention
  • FIG. 2 is a schematic perspective view showing the structure of a base in which a ram is mounted and a sample is carried in the present invention
  • Figure 3 is a front view showing the structure of the base
  • Figure 4 is a cross-sectional view taken along line A-A of Figure 3;
  • a soft tissue simulator for magnetic resonance testing includes a gas path portion and a sample motion simulation mechanism, wherein the gas path portion includes a pneumatically generated connection.
  • the sample motion simulation mechanism includes a base 41 carrying a soft tissue or an organ sample, a head 42 facing the sample, and a driving head 42 reciprocating relative to the sample.
  • the air cylinder 43 and the base 41 are provided with adjusting means for adjusting the distance between the air cylinder 43 and the sample.
  • the adjusting device comprises two screw rods 47 which are rotatably connected to the base 41 at one end, and a sliding table 48 which is screwed to the two screw rods at both ends respectively.
  • the top plate 49 rotatably connected to the other end of the two screw rods 47 and the knob 51 disposed on the top plate 49 for driving the rotation of the two screw rods 47 are disposed on the slide table 48 and fixed by bolts.
  • the indenter 42 is driven to move in a pneumatic manner, and the indenter 42 is driven by the air cylinder 43.
  • the inside of the air cylinder 43 of the present invention is divided by the piston 44 into a first chamber 45 and a second chamber 46, and the piston is 44 is coupled to the indenter 42.
  • the knob 51 When placing samples of different sizes on the base 41, it is necessary to adjust the distance between the air cylinder 43 and the base 41.
  • the knob 51 When adjusting, the knob 51 is rotated to rotate the two screws 47, so that the slide 48 is up or toward the screw 47.
  • the lower movement causes the air cylinder 43 to ascend or descend relative to the base 41.
  • the two ends of the screw rod 47 are respectively rotatably connected with the base 41 and the top plate 49 through bearings, and the ends of the two screw rods 47 located in the top plate 49 are passed.
  • the rack is driven by the knob 51, so that the knob 51 can be rotated to rotate the two screws 47.
  • the medium pneumatic generating source 10 is an air compressor that generates compressed air.
  • the aerodynamic generation source 10 is adjusted and controlled to simulate the movement of human organs or the movement of soft tissues in human body tests.
  • the two-position five-way electromagnetic reversing valve 30 In the initial position, the two-position five-way electromagnetic reversing valve 30 is connected to the right position, and the compressed air reaches the outlet 2 through the intake port 1 of the two-position five-way electromagnetic reversing valve 30, enters the first chamber 45 of the air cylinder 43, and the piston 44
  • the driving head 42 is retracted; when the two-position five-way electromagnetic reversing valve 30 is reversed, the compressed air acts on the two-position five-way electromagnetic reversing valve through the left position of the air inlet 1 / the air outlet 4, so that the second five
  • the electromagnetic reversing valve 30 is inserted to the left position, and the compressed air enters the second chamber 46 of the air cylinder 43, so that the piston 44 is extended, so that the indenter 42 presses the sample 60; when the two-position five-way electromagnetic reversing valve 30 is changed again In the forward direction, the right position of the two-position five-way electromagnetic reversing valve is accessed
  • the state of the test sample is simulated according to the magnetic resonance-based soft tissue physical and mechanical property test method. Adjusting and controlling the pneumatic generating source 10 to cause the indenter 42 to generate periodic motion or one-way motion to simulate the human body. The movement of the organ or the movement of the soft tissue in the human body test controls the motion state of the sample to be tested, and the corresponding experimental results are obtained.

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

一种用于磁共振测试的软组织模拟器及模拟测试方法，模拟器包括承载软组织或器官样本（60）的底座（41）、正对样本（60）的压头（42）、驱动压头（42）相对样本（60）往复运动的气筒（43）以及对气筒（43）供气的气源，气筒（43）内由活塞（44）分隔成第一腔室（45）和第二腔室（46），活塞（44）与压头（42）连接；气源包括气动发生源（10）、与气动发生源（10）连接的具有第一出气口和第二出气口的换向阀（30），换向阀（30）的第一出气口和第二出气口分别与气筒（43）的第一腔室（45）和第二腔室（46）连通。软组织模拟器基于气动驱动，利用换向阀（30）控制压缩空气均匀地进入气筒（43）的第一腔室（45）或第二腔室（46）以控制压头（42）的运动，位移分布均匀，控制精度好；通过控制压头（42）周期运动或单向运动，模拟人体器官的运动或人体测试中软组织的运动，通用于基于磁共振方法的软组织物理特性测量模拟。

Description

一种用于磁共振测试的软组织模拟器及模拟测试方法 技术领域
本发明涉及软物质与实验力学技术领域，尤其涉及一种用于磁共振测试的软组织模拟器及模拟测试方法。
背景技术
基于磁共振的软组织物理特性测试是目前基于影像临床诊断的重要发展方向。目前基于磁共振的人体软组织物理特性测试主要方法有标记成像技术和弹性成像技术等。应用动物与人工样本进行模拟测试是开展临床应用前，针对新的测量方法与疾病检测应用的主要手段。
目前在对样本进行模拟测试时，施加位移的驱动方式主要为薄膜驱动和压电陶瓷驱动。采用薄膜进行驱动的方式：其驱动膜包覆在气囊外，进行薄膜气动对样本施加位移，缺点是难以进行标记成像的模拟与测试，且驱动位移分布不易控制；采用压电陶瓷进行驱动：通过机械连接的方式将压电驱动器产生的位移传递到输出端，其缺点是难以对大样本进行模拟测试，位移幅度调节范围有限，难以进行标记成像的模拟与测试。
现有的对样本进行模拟测试的装置的主要缺点是：
1、主要针对特定一种磁共振成像方法，驱动位移范围有限，不能面向不同成像方式的多种不同位移范围；
2、气动驱动方式中，以膜驱动方式产生的位移不易控制，分布不均匀；
3、压电驱动的位移较小，难以应用大样本进行测量。
有鉴于上述的缺陷，本设计人，积极加以研究创新，以期创设一种新型的 用于磁共振测试的软组织模拟器及模拟测试方法，使其更具有产业上的利用价值。
发明内容
为解决上述技术问题，本发明的目的是提供一种用于磁共振测试的软组织模拟器及模拟测试方法，其驱动位移幅度范围较大，可以对不同尺寸的样本进行驱动、位移分布均匀，控制精度好且通用于基于磁共振方法的软组织物理特性测量模拟。
本发明的用于磁共振测试的软组织模拟器，包括承载软组织样本的底座、正对样本的压头、驱动压头相对样本往复运动的气筒以及对气筒供气的气源，所述气筒内由活塞分隔成第一腔室和第二腔室，所述活塞与所述压头连接；所述气源包括气动发生源、与气动发生源连接的具有第一出气口和第二出气口的换向阀，所述换向阀的第一出气口和第二出气口分别与所述气筒的第一腔室和第二腔室连通。
进一步的，所述底座上设有调节所述气筒与所述样本之间的间距的调节装置，所述调节装置包括一端与所述底座转动连接的两丝杆、两端分别与两丝杆螺纹连接的滑台、与两丝杆另一端转动连接的顶板、设置在顶板上驱动两丝杆转动的旋钮，所述气筒设置在所述滑台上。
进一步的，所述丝杆的两端均通过轴承分别与所述底座与顶板转动连接。
进一步的，所述气动发生源与换向阀之间连接有单向节流阀。
进一步的，所述换向阀为二位五通电磁换向阀。
进一步的，所述气动发生源为产生压缩空气的空气压缩机。
本发明的利用上述的用于磁共振测试的软组织模拟器进行模拟测试的方 法，包括步骤：
(1)将合适尺寸的软组织或器官样本放置在所述底座上并与所述压头接触；
(2)启动气动发生源，控制换向阀的方向，使所述第一出气口与所述第一腔室连通或使所述第二出气口与所述第二腔室连通，使压头收回或下压样本，调节换向阀的方向，使压头产生周期运动或单向运动；
(3)基于磁共振的软组织物理力学特性，调节控制气动发生源，模拟人体器官的运动或人体测试中软组织的运动。
本发明的利用上述的用于磁共振测试的软组织模拟器进行模拟测试的方法，包括步骤：
(1)将软组织或器官样本放置在所述底座上，根据样本的尺寸，转动所述旋钮调节所述滑台在所述丝杆上的高度使所述压头与样本接触；
(2)启动气动发生源，控制换向阀的方向，使所述第一出气口与所述第一腔室连通或使所述第二出气口与所述第二腔室连通，使压头收回或下压样本，调节换向阀的方向，使压头产生周期运动或单向运动；
(3)基于磁共振的软组织物理力学特性，调节控制气动发生源，模拟人体器官的运动或人体测试中软组织的运动。
本发明的利用上述的用于磁共振测试的软组织模拟器进行模拟测试的方法，包括步骤：
(1)将合适尺寸的软组织或器官样本放置在所述底座上并与所述压头接触，或，将软组织或器官样本放置在所述底座上，根据样本的尺寸，转动所述旋钮调节所述滑台在所述丝杆上的高度使所述压头与样本接触；
(2)启动气动发生源，打开单向节流阀，控制换向阀的方向，使所述第一 出气口与所述第一腔室连通或使所述第二出气口与所述第二腔室连通，使压头收回或下压样本，调节换向阀的方向，使压头产生周期运动或单向运动；
(3)基于磁共振的软组织物理力学特性，调节控制气动发生源，模拟人体器官的运动或人体测试中软组织的运动。
借由上述方案，本发明至少具有以下优点：
1、基于气动驱动，利用换向阀控制压缩空气均匀地进入气筒的第一腔室或第二腔室以控制压头的运动，位移分布均匀，控制精度好；
2、气筒相对底座之间的位移可根据样本的尺寸进行调节，驱动位移幅度范围较大，位移幅度可控制可调节；
3、通过控制压头的周期运动或单向运动，模拟人体器官的运动或人体测试中软组织的运动，通用于基于磁共振方法的软组织物理特性测量模拟。
上述说明仅是本发明技术方案的概述，为了能够更清楚了解本发明的技术手段，并可依照说明书的内容予以实施，以下以本发明的较佳实施例并配合附图详细说明如后。
附图说明
图1是本发明的用于磁共振测试的软组织模拟器的结构示意图；
图2是本发明中安装压头并承载样本的底座立体结构示意图；
图3是底座的结构主视图；
图4是图3中沿A-A线的剖视图。
具体实施方式
下面结合附图和实施例，对本发明的具体实施方式作进一步详细描述。以下实施例用于说明本发明，但不用来限制本发明的范围。
参见图1至图4，本发明一较佳实施例所述的一种用于磁共振测试的软组织模拟器，包括气路部分和样本运动模拟机构，其中，气路部分包括依次连接的气动发生源10、单向节流阀20和二位五通电磁换向阀30；样本运动模拟机构包括承载软组织或器官样本的底座41、正对样本的压头42、驱动压头42相对样本往复运动的气筒43，底座41上设有调节气筒43与样本之间的间距的调节装置，调节装置包括一端与底座41转动连接的两丝杆47、两端分别与两丝杆螺纹连接的滑台48、与两丝杆47另一端转动连接的顶板49、设置在顶板49上驱动两丝杆47转动的旋钮51，气筒43穿设在滑台48上，并用螺栓固定。
本发明中通过气动的方式驱动压头42运动，而压头42由气筒43驱动，具体的，本发明的气筒43内由活塞44分隔成第一腔室45和第二腔室46，将活塞44与压头42连接。为使活塞44可带动压头42往复运动，本发明将气筒43的第一腔室45和第二腔室46分别与二位五通电磁换向阀30的第一出气口和第二出气口连通，当气体通过二位五通电磁换向阀30的第一出气口进入气筒43的第一腔室45内，在气压的作用下，活塞44向下移动；当气体通过二位五通电磁换向阀30的第二出气口进入气筒43的第二腔室46内，在气压的作用下，活塞44向上移动，活塞44的上下移动驱动压头42相对样本往复运动。
当在底座41上放置不同尺寸的样本时，需要调节气筒43与底座41之间的距离，调节时，转动旋钮51，使两丝杆47转动，从而使滑台48沿丝杆47向上或向下移动，从而带动气筒43相对底座41上升或下降。为使两丝杆47可相对底座41和顶板49转动，本发明将丝杆47的两端均通过轴承分别与底座41与顶板49转动连接，位于顶板49内的两丝杆47的端部通过齿条与旋钮51传动，从而转动旋钮51即可使两丝杆47转动。
为了使气动发生源10给出的气体能够对活塞44施加足够的气压，本发明 中气动发生源10为产生压缩空气的空气压缩机。
利用上述的用于磁共振测试的软组织模拟器进行模拟测试的方法，包括步骤：
(1)将合适尺寸的软组织或器官样本60放置在载玻片上，将载玻片连同样本放置在底座41上并与压头42接触，或，将软组织或器官样本放置在载玻片上，将载玻片连同样本放置在底座41上，根据样本的尺寸，转动旋钮51调节滑台48在丝杆47上的高度使压头42与样本60接触；
(2)启动气动发生源10，控制二位五通电磁换向阀30的方向，使第一出气口与第一腔室45连通或使第二出气口与第二腔室46连通，使压头42收回或下压样本，调节二位五通电磁换向阀30的方向，使压头42产生周期运动或单向运动；若要控制压缩空气的流量，可同时打开单向节流阀20；
(3)基于磁共振的软组织物理力学特性，调节控制气动发生源10，模拟人体器官的运动或人体测试中软组织的运动。
本发明的工作原理如下：
初始位置，二位五通电磁换向阀30右位接入，压缩空气经二位五通电磁换向阀30的进气口1到达出口2，进入气筒43的第一腔室45，活塞44带动压头42收回；当二位五通电磁换向阀30换向时，压缩空气经进气口1/出气口4的左位作用在二位五通电磁换向阀上，使得二位五通电磁换向阀30左位接入，压缩空气进入气筒43的第二腔室46，使得活塞44伸出，使得压头42下压样本60；当二位五通电磁换向阀30再次换向时，二位五通电磁换向阀的右位接入，如此，控制活塞44的运动以控制压头42的运动。
依据基于磁共振的软组织物理力学特性测试方法，对测试样本的状态进行模拟。调节控制气动发生源10，使压头42产生周期运动或单向运动，模拟人体 器官的运动或人体测试中软组织的运动，控制所测试样本的运动状态，得到相应的实验结果。
以上所述仅是本发明的优选实施方式，并不用于限制本发明，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明技术原理的前提下，还可以做出若干改进和变型，这些改进和变型也应视为本发明的保护范围。

Claims (9)

  1. 一种用于磁共振测试的软组织模拟器，其特征在于：包括承载软组织或器官样本的底座、正对样本的压头、驱动压头相对样本往复运动的气筒以及对气筒供气的气源，所述气筒内由活塞分隔成第一腔室和第二腔室，所述活塞与所述压头连接；所述气源包括气动发生源、与气动发生源连接的具有第一出气口和第二出气口的换向阀，所述换向阀的第一出气口和第二出气口分别与所述气筒的第一腔室和第二腔室连通。
  2. 根据权利要求1所述的用于磁共振测试的软组织模拟器，其特征在于：所述底座上设有调节所述气筒与所述样本之间的间距的调节装置，所述调节装置包括一端与所述底座转动连接的两丝杆、两端分别与两丝杆螺纹连接的滑台、与两丝杆另一端转动连接的顶板、设置在顶板上驱动两丝杆转动的旋钮，所述气筒设置在所述滑台上。
  3. 根据权利要求2所述的用于磁共振测试的软组织模拟器，其特征在于：所述丝杆的两端均通过轴承分别与所述底座与顶板转动连接。
  4. 根据权利要求1或2所述的用于磁共振测试的软组织模拟器，其特征在于：所述气动发生源与换向阀之间连接有单向节流阀。
  5. 根据权利要求4所述的用于磁共振测试的软组织模拟器，其特征在于：所述换向阀为二位五通电磁换向阀。
  6. 根据权利要求4所述的用于磁共振测试的软组织模拟器，其特征在于：所述气动发生源为产生压缩空气的空气压缩机。
  7. 利用如权利要求1所述的用于磁共振测试的软组织模拟器进行模拟测试的方法，其特征在于，包括步骤：
    (1)将合适尺寸的软组织或器官样本放置在所述底座上并与所述压头接触；
    (2)启动气动发生源，控制换向阀的方向，使所述第一出气口与所述第一腔室连通或使所述第二出气口与所述第二腔室连通，使压头收回或下压样本，调节换向阀的方向，使压头产生周期运动或单向运动；
    (3)基于磁共振的软组织物理力学特性，调节控制气动发生源，模拟人体器官的运动或人体测试中软组织的运动。
  8. 利用如权利要求2或3所述的用于磁共振测试的软组织模拟器进行模拟测试的方法，其特征在于，包括步骤：
    (1)将软组织或器官样本放置在所述底座上，根据样本的尺寸，转动所述旋钮调节所述滑台在所述丝杆上的高度使所述压头与样本接触；
    (2)启动气动发生源，控制换向阀的方向，使所述第一出气口与所述第一腔室连通或使所述第二出气口与所述第二腔室连通，使压头收回或下压样本，调节换向阀的方向，使压头产生周期运动或单向运动；
    (3)基于磁共振的软组织物理力学特性，调节控制气动发生源，模拟人体器官的运动或人体测试中软组织的运动。
  9. 利用如权利要求4所述的用于磁共振测试的软组织模拟器进行模拟测试的方法，其特征在于，包括步骤：
    (1)将合适尺寸的软组织或器官样本放置在所述底座上并与所述压头接触，或，将软组织或器官样本放置在所述底座上，根据样本的尺寸，转动所述旋钮调节所述滑台在所述丝杆上的高度使所述压头与样本接触；
    (2)启动气动发生源，打开单向节流阀，控制换向阀的方向，使所述第一出气口与所述第一腔室连通或使所述第二出气口与所述第二腔室连通，使压头收回或下压样本，调节换向阀的方向，使压头产生周期运动或单向运动；
    (3)基于磁共振的软组织物理力学特性，调节控制气动发生源，模拟人体 器官的运动或人体测试中软组织的运动。
PCT/CN2017/080849 2017-04-12 2017-04-18 一种用于磁共振测试的软组织模拟器及模拟测试方法 Ceased WO2018188105A1 (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US15/769,333 US10859660B2 (en) 2017-04-12 2017-04-18 Soft tissue simulator for magnetic resonance testing and method for simulated testing

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201710237378.7A CN106980096B (zh) 2017-04-12 2017-04-12 一种用于磁共振测试的软组织模拟器及模拟测试方法
CN201710237378.7 2017-04-12

Publications (1)

Publication Number Publication Date
WO2018188105A1 true WO2018188105A1 (zh) 2018-10-18

Family

ID=59344355

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2017/080849 Ceased WO2018188105A1 (zh) 2017-04-12 2017-04-18 一种用于磁共振测试的软组织模拟器及模拟测试方法

Country Status (3)

Country Link
US (1) US10859660B2 (zh)
CN (1) CN106980096B (zh)
WO (1) WO2018188105A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113647930B (zh) * 2021-07-20 2024-08-30 首都医科大学 核磁环境下人体下颌三角区施力装置
CN113866544B (zh) * 2021-09-29 2023-05-30 中国科学院光电技术研究所 一种测量压电陶瓷驱动器负载下位移输出的装置
CN115290425B (zh) * 2022-10-10 2022-12-09 山东中医药大学附属医院 一种模拟膝关节软骨荷载的检测装置及方法
CN117929673B (zh) * 2024-03-25 2024-05-31 四川汇邦环保科技有限公司 一种水质氨氮在线监测装置

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8380281B2 (en) * 2010-05-01 2013-02-19 The Johns Hopkins University Compression device for enhancing normal/abnormal tissue contrast in MRI including devices and methods related thereto
CN104000591A (zh) * 2014-06-11 2014-08-27 合肥工业大学 一种磁共振弹性成像主动吸附式桥接激励装置
CN104771170A (zh) * 2015-05-11 2015-07-15 合肥工业大学 面向磁共振弹性成像的气动增压激励装置及方法
CN205080003U (zh) * 2015-07-14 2016-03-09 苏州大学张家港工业技术研究院 生物软组织的力学特性测试仪
CN106370519A (zh) * 2016-10-13 2017-02-01 苏州大学张家港工业技术研究院 生物软组织微观力学特性测试仪
CN206638796U (zh) * 2017-04-12 2017-11-14 苏州大学 一种用于磁共振测试的软组织模拟器

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616857A (en) * 1996-01-25 1997-04-01 Instron Corporation Penetration hardness tester
GB9724457D0 (en) * 1997-11-20 1998-01-14 Dage Precision Ind Limited Test apparatus
CA2306275C (en) * 1999-04-23 2009-11-03 Bio Syntech Canada Inc. Universal mechanical testing device
DE102006037160B4 (de) * 2006-04-13 2009-10-08 Charité - Universitätsmedizin Berlin Vorrichtung für die Magnetresonanzelastographie (MRE)
US8706192B2 (en) * 2008-02-16 2014-04-22 Geng Li Magnetic resonance elastograph system with hydraulic driver
US20100049029A1 (en) * 2008-08-20 2010-02-25 Hong Kong Applied Science And Technology Research Institute Co., Ltd. Piezoelectric magnetic resonance elastograph (mre) driver system
US9295407B2 (en) * 2012-05-10 2016-03-29 Ohio State Innovation Foundation Hydraulically-powered system and method for achieving magnetic resonance elastography
US9924963B2 (en) * 2012-12-13 2018-03-27 Novartis Ag Vitrectomy probe with integral valve
DE102015204868A1 (de) * 2015-03-18 2016-09-22 Charité - Universitätsmedizin Berlin Elastographieeinrichtung und Elastographieverfahren
US10694973B2 (en) * 2015-04-06 2020-06-30 Albert Einstein College Of Medicine Piston device for magnetic resonance elastography and uses thereof
CN104977211B (zh) * 2015-07-14 2018-07-13 苏州大学张家港工业技术研究院 生物软组织的力学特性测试仪
CN105300812B (zh) * 2015-10-26 2017-11-28 苏州大学 生物软组织力学特性测试仪及生物软组织的力学测试方法
CN205483873U (zh) * 2016-01-25 2016-08-17 中国科学院声学研究所东海研究站 生物组织弹性测量仪

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8380281B2 (en) * 2010-05-01 2013-02-19 The Johns Hopkins University Compression device for enhancing normal/abnormal tissue contrast in MRI including devices and methods related thereto
CN104000591A (zh) * 2014-06-11 2014-08-27 合肥工业大学 一种磁共振弹性成像主动吸附式桥接激励装置
CN104771170A (zh) * 2015-05-11 2015-07-15 合肥工业大学 面向磁共振弹性成像的气动增压激励装置及方法
CN205080003U (zh) * 2015-07-14 2016-03-09 苏州大学张家港工业技术研究院 生物软组织的力学特性测试仪
CN106370519A (zh) * 2016-10-13 2017-02-01 苏州大学张家港工业技术研究院 生物软组织微观力学特性测试仪
CN206638796U (zh) * 2017-04-12 2017-11-14 苏州大学 一种用于磁共振测试的软组织模拟器

Also Published As

Publication number Publication date
CN106980096A (zh) 2017-07-25
US20190064304A1 (en) 2019-02-28
US10859660B2 (en) 2020-12-08
CN106980096B (zh) 2023-11-24

Similar Documents

Publication Publication Date Title
WO2018188105A1 (zh) 一种用于磁共振测试的软组织模拟器及模拟测试方法
CN111337347B (zh) 植物微观力学检测装置及其检测方法
CN113214991B (zh) 一种模拟细胞力学微环境的细胞培养装置
CN108088763B (zh) 多头平面往复式摩擦磨损试验机
CN105445008A (zh) 气动人工肌肉静态特性综合测试装置及驱动系统
CN105865915A (zh) 一种软材料力学性能测量装置及方法
CN109781359A (zh) 燃料电池双极板的密封性检测装置与方法
WO2016004394A1 (en) Microfluidic cardiovascular system and method
WO2018068338A1 (zh) 生物软组织微观力学特性测试仪
CN206638796U (zh) 一种用于磁共振测试的软组织模拟器
CN219830648U (zh) 一种建筑幕墙抗风压检测装置
CN209470825U (zh) 燃料电池双极板的密封性检测装置
CN102759481A (zh) 一种多细胞的力学模拟实验平台
CN106781957A (zh) 男性盆腔器官群实体模型的制作方法
CN106338466A (zh) 一种用于着色光纤油墨固化度检验的擦拭装置
WO2006111385A8 (en) Ergometer suitable for use in a magnetic resonance apparatus
CN104911831B (zh) 一种柔性材料的运动装置、运动方法及缝纫装置
CN202676542U (zh) 一种多细胞的力学加载装置及模拟实验平台
CN116380748B (zh) 一种微生物固化黄土的渗透性及抗侵蚀性测定装置
CN203433728U (zh) 一种心脏腔室模拟器驱动机构
CN204789126U (zh) 一种水泥土直接拉伸仪的导轨结构
CN205506586U (zh) 一种鞋底疲劳压缩试验机
CN222671349U (zh) 一种气缸气密性检测装置
CN210243434U (zh) 软骨渗透性测量装置
Chen et al. Deformation and dynamic response of a soft cavity facilitating robotic chewing of foods

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 17905524

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 17905524

Country of ref document: EP

Kind code of ref document: A1