WO2018170281A1 - Automated batch data analysis - Google Patents
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- WO2018170281A1 WO2018170281A1 PCT/US2018/022661 US2018022661W WO2018170281A1 WO 2018170281 A1 WO2018170281 A1 WO 2018170281A1 US 2018022661 W US2018022661 W US 2018022661W WO 2018170281 A1 WO2018170281 A1 WO 2018170281A1
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Classifications
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- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/418—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM]
- G05B19/4188—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM] characterised by CIM planning or realisation
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- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/418—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM]
- G05B19/4183—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM] characterised by data acquisition, e.g. workpiece identification
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- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B2219/00—Program-control systems
- G05B2219/30—Nc systems
- G05B2219/31—From computer integrated manufacturing till monitoring
- G05B2219/31372—Mes manufacturing execution system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P90/00—Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
- Y02P90/02—Total factory control, e.g. smart factories, flexible manufacturing systems [FMS] or integrated manufacturing systems [IMS]
Definitions
- the present invention relates to a system and method for automated batch data analysis, for example, automatically identifying, extracting, and outputting certain information in relatable form along with context corresponding to the extracted information for analysis.
- the automated batch data analysis for instance, may be performed in connection with pharmaceutical production.
- MES manufacturing execution systems
- An MES may be integrated with one or more digital control systems to collect manually entered data by operators, data from enterprise planning systems, data captured from plant-floor control systems, etc. while also verifying that the data is within expected ranges (and alerting operators if any abnormal situations arise).
- the consolidated data may then be entered into one or more batch record documents, which may be saved in a MES database.
- an operator desires to retrieve and analyze a set of parameters captured from an external analytics system, the specific information related to the parameter must be "pulled out" from the vast amounts of information in the MES database.
- the invention is directed to systems and methods for automated batch data analysis. Certain information in the data may be tagged as information of interest. In at least that regard, the tagged information may be extracted or "pushed out" to a separate database for further analysis.
- the tagging procedure may be implemented during the building of the set of instructions for performing a particular task associated with an external analytics system associated with the collected data, for example, pH values of a titration process in a bioreactor tank.
- the pushed out information may also be provided with contextual data or information that may give the user and/or operator some form of context with respect to the information that is pushed out.
- Figures 1 and 2 illustrate example systems in accordance with one or more aspects of the invention.
- Figure 3 illustrates another system in accordance with one or more aspects of the invention.
- Figure 4 illustrates an example flow diagram of a recipe in accordance with one or more aspects of the invention.
- Figure 5 illustrates an example database table in accordance with one or more aspects of the invention.
- Figure 6 illustrates an example flow chart in accordance with one or more aspects of the invention.
- the invention is directed to automated batch data analysis.
- a computing device of an MES may automatically identify, extract, and output one or more parameters associated with an MES recipe (e.g., a combination or a set of instructions for executing certain tasks associated with an external analytics system), for instance, to a database table, output file, etc., for further analysis.
- the MES in one aspect, may be used to execute batch processes that include the implementation of one or more bioreactors and/or related equipment for producing biological products.
- the one or more parameters that are output may be parameters related to process conditions inside the tank that are of interest for subsequent analysis, such as the pH values of the bioreactor medium in the tank prior to, during, and after titration.
- further information or context related to the one or more parameters may also be provided, such as bioreactor tank identification information, plant location information, the exact times the pH measurements were taken, etc.
- the one or more parameters to be extracted and output may be "tagged" prior to executing the MES recipe.
- every parameter that is of interest for each of the instructions that make up the computer instruction set are tagged so that when a particular instruction is executed (e.g., titrate), the tagged parameter (e.g., pH of the bioreactor medium at the time of titration) is identified, extracted, and may be "pushed out” to a separate database, which may be further processed and analyzed.
- certain information in the data that is of interest is "tagged” prior to the collection of the information in the data so that the "tagged” information is automatically identified and extracted (e.g., "pushed") to a separate database for further analysis.
- one of the numerous advantages of the present disclosure is avoiding the slow, resource-intensive processing of information associated with the above-described "pull" procedure in conventional batch data processing methods.
- the extracted information (based on the tags) may be stored in local memory of a computing device, as opposed to executing database calls to retrieve the information across numerous tables in the MES database.
- Another advantage of the disclosure is that the tagged data and/or information is pushed out to a messaging queue or other data repository while the MES recipe is running, and thus, the extraction of data does not affect the recipe process.
- FIG. 1 illustrates an example system 100 in accordance with one or more aspects of the invention.
- the system 100 may include one or more computing devices, e.g., computer 120, server computer 130, mobile computer 140, smartphone device 150, tablet computer 160, and storage device 170 connected to a network 190.
- the computer 120 may be a desktop computer, which is intended for use by one or more users.
- the computer 120 includes various components associated with a desktop computer, such as one or more processors 102, memory 104, e.g., permanent or flash memory (which includes instructions 105 and data 106), one or more interfaces 108, and a display 110.
- the server computer 130 may include at least one processor, memory which also includes instructions and data, one or more interfaces, and/or a display (not shown).
- the mobile computing device 140 may be a laptop (or any type of computer that is portable or mobile, such as an Ultrabook) and also include components similar to the computer 120 and/or server computer 130.
- the computer 120 may be configured to communicate with the server computer 130, the mobile computer 140, the smartphone device 150, the tablet computer 160 and/or the storage device 170 via the network 190.
- the cascaded blocks associated with a particular component illustrate that more than one of those components may exist, which is only an example, and it may be understood that different components can be cascaded and that there may be numerous variations thereof.
- the computer 120 may include a processor 102 (e.g., controller, which will be further discussed below), which instructs the various components of computer 120 to perform tasks based on the processing of certain information, such as instructions 105 and/or data 106 stored in the memory 104.
- the processor 102 may be hardware that can be configured to perform one or more operations, e.g., adding, subtracting, multiplying, comparing, jumping from one program to another program, operating input and output, etc., and may be any standard processor, such as a central processing unit (CPU), or may be a dedicated processor, such as an application-specific integrated circuit (ASIC) or a field programmable gate array (FPGA) or an industrial process controller.
- ASIC application-specific integrated circuit
- FPGA field programmable gate array
- the processor 102 may have any suitable configuration and/or configuration of circuitry that processes information and/or instructs the components of computer 120. While one processor block is shown in Figure 1, it may be understood that the computer 120 may also include multiple processors to individually or collectively perform tasks, as described above. In one or more embodiments, the computer 120 may be an industrial controller.
- Memory 104 may be any type of hardware configured to store information accessible by the processor 102, such as instructions 105 and data 106, which can be executed, retrieved, manipulated, and/or stored by the processor 102. It may be physically contained in the computer 120 or coupled to the computer 120.
- memory 104 may be ROM, RAM, CD-ROM, hard drive, write-capable, read-only, etc.
- the instructions 105 stored in memory 104 may include any set of instructions that can be executed directly or indirectly by the processor 102.
- the instructions 105 may be one or more "steps" associated with software that can be executed by the processor 102.
- the instructions 105 may be also transferred onto memory 104 in various way, e.g., from server computer 130 and/or storage device 170 via network 190.
- the data 106 stored in memory 104 may be retrieved, stored or modified by the processor 102, for example, in accordance with the instructions 105.
- the data 106 may be stored as a collection of data.
- the data 106 may be stored in registers, in a database as a table having multiple fields and records, such as an XML.
- the data 106 may be formatted in any computer readable format such as, but not limited to, ASCII, Extended Binary-Coded Decimal Interchange Code (EBCDIC), binary, Objectivity, SQL or other suitable database formats, etc.
- the data 106 may also be any information sufficient to identify the relevant data, such as text, codes, pointers, information used by one or more functions to calculate the data, etc. Similar to the instructions 105, the data 106 may also be transferred onto memory 104 from various components via network 190.
- Interface 108 may be a particular device (such as a field-mounted instrument, processor-to-processor communication, keyboard, mouse, touch sensitive screen, camera, microphone, etc.), a connection or port or wirelessly that allows the reception of information and data, such as interactions from a user or information/data from various components via network 190.
- the interface 122 may include one or more input/output ports.
- the input/output ports may include any suitable type of data port, such as a digital control bus (FoundationTM, ProfitbusDPTM, DeviceNetTM, Modbus IEEE RS-485, Modbus/IP, Serial IEEE RS-232, universal serial bus (USB) drive, zip drive, card reader, CD drive, DVD drive, etc.
- the display 110 may be any suitable type of device capable of communicating data to a user.
- the display 110 may be a liquid-crystal display (LCD) screen, a light emitting diode (LED) screen, a plasma screen, etc.
- the display 110 may provide to the user various types of information, such as visual representations of the software that can be executed by the computer 120 and various data, and the like, associated therewith.
- a user may input information and/or data using the interface 108.
- the interface 108 may be a graphical user interface (GUI) that is displayed to the user/operator on the display 110.
- GUI graphical user interface
- OI operator interface
- the server computer 130 may be rack mounted on a network equipment rack and/or located in a data center. In some examples, via the network 190, the server computer 130 may serve various requests associated with the programs executed on the computer 120, mobile computer 140, the smartphone device 150, the tablet computer 160, and/or the storage device 170. In further examples, the server computer 130 may be part of a plurality of server computers that support a back-end system (which may be "invisible" to users).
- Mobile or portable computing devices such as the mobile computer 140, the smartphone device 150, and tablet computer 160, may include similar components and functions to the computer 120 and/or server computer 130, e.g., one or more processors, memory, input/output capabilities, display, etc. and, by common Thin Client and Remote Desktop protocols, access display 110 and interface 108 present on the computer 120.
- server computer 130 e.g., one or more processors, memory, input/output capabilities, display, etc. and, by common Thin Client and Remote Desktop protocols, access display 110 and interface 108 present on the computer 120.
- the mobile computer 140 may be any type of device that is mobile or portable with computing capability and connectivity to a network.
- the mobile computer 140 may be a laptop, an Ultrabook, smartphone, PDA, tablet computer, a wearable computing device, etc.
- the mobile computer 140 may also have one or more processors, memory, user interfaces, wired or wireless network connection hardware, and other types of components associated with a mobile computing device.
- the mobile computer 140 may be able to connect to network 190 via a wired or a wireless connection and communicate with other components connected to the network 190, such as server computer 130, storage device 170, etc.
- the smartphone device 150 may be a mobile cellular phone with computing capability and network connectivity.
- the smartphone 150 may include one or more processors, memory, one or more user interfaces, such as a QWERTY keypad, voice recognition, a camera, image sensors, a global positioning system (GPS), accelerator, temperature sensors, etc.
- the smartphone device 150 may be configured to execute computer instructions, applications, programs, and any set of instructions and data.
- the tablet computer 160 may also include one or more processors (configured to execute computer instructions and/or applications), memory, one or more interfaces, a touchscreen display, sensors, microphone, camera, speakers, networking hardware (configured to connect to a network, such as network 190, via a wired or wireless connection), etc.
- processors configured to execute computer instructions and/or applications
- memory one or more interfaces
- a touchscreen display sensors, microphone, camera, speakers
- networking hardware configured to connect to a network, such as network 190, via a wired or wireless connection
- the storage device 170 may be configured to store a large quantity of data and may also be configured to transfer such data when requested or accessed by other components of network 190.
- the storage device 170 may be a collection of storage components, such as ROM, RAM, hard-drives, solid-state drives, removable drives, network storage, virtual memory, multi-leveled cache, registers, CD, DVD, etc.
- the storage device 170 may be configured so other components of network 190, such as the computer 120 and/or server computer 130, can access and provide data to other components connected to the network 190.
- a device such as the storage device 170 may be considered the MES database for storage of data related to batch processes and/or batch products.
- the network 190 may be any suitable type of network, wired or wireless, configured to facilitate the transmission of data, instructions, etc. between one or more components of the network.
- the network 190 may be a local area network (LAN) (e.g., Ethernet or other IEEE 802.03 LAN technologies), Wi-Fi (e.g., IEEE 802.11 standards), wide area network (WAN), virtual private network (VPN), global area network (GAN), or any combinations thereof.
- LAN local area network
- Wi-Fi e.g., IEEE 802.11 standards
- WAN wide area network
- VPN virtual private network
- GAN global area network
- the computer 120, server computer 130, mobile computer 140, smartphone device 150, and/or tablet computer 160 may connect to and communicate with one another via the network 190.
- computer 120 may be a desktop computer in the above-described examples, computer 120 is not limited to just desktop computers, and any of the computers illustrated in Figure 1 may be any device capable of processing data and/or instructions and transmitting and/or receiving data. Moreover, it will be understood by those of ordinary skill in the art that those components may actually include multiple processors, memories, instructions, data or displays that may or may not be stored within the same physical housing. For example, some or all of the instructions 105 and data 106 may be stored on removable media, or may be stored in a location physically remote from, yet still accessible by, the processor 102. And although the various components of Figure 1 are connected to the network 190, it may be understood that the components may also be connected to each other, in any suitable combination.
- FIG. 2 illustrates another example system 200 in accordance with aspects of the invention.
- the system 200 represents a manufacturing execution system (MES), and the various components depicted in Figure 1, may be configured in such a manner to facilitate the control of the bioreactors and related equipment for the production of biological products, such as equipment 202 for fermentation and/or harvest, equipment 204 for microfiltration and purification (e.g., chromatography skid), equipment 206 for media preparation, such as Clean In Place (CIP) systems and System In Place (SIP) systems, equipment 208 for buffer preparation, and various field devices (e.g., sensors with transmitters, scales, switches, pumps, control valves, discrete valves, pumps with fixed-speed starters or variable frequency drives, agitators with variable frequency drives, discrete valves with limit switches).
- CIP Clean In Place
- SIP System In Place
- One or more computers may be dispersed throughout the system 200 and each computer may be dedicated to certain control and/or portions of the depicted system.
- server computers such as server computer 130 of Figure 1
- server computers may also be physical or virtual and dispersed throughout the system 200 and dedicated to certain portions of the system to facilitate the communication of data and instructions.
- the various system components facilitated by the MES may be for one or more chemical processes (e.g., components such as a chemical reactor, etc.) in addition to and/or alternative to components used for small molecule processes, such as the components depicted in Figure 1.
- FIG. 2 illustrates a stand-alone MES
- an MES may be implemented with a control system to operate as one system.
- the system 200 of Figure 2 which is an MES system, may be combined with a plant wide control system (PWCS) to operate as one system.
- PWCS plant wide control system
- FIG. 3 illustrates a system 300, for example, incorporating an MES (e.g., system
- the Professional Plus Workstation (PRO) 302 may be the database for the system 300
- the Batch Executive (EXEC) 304 stores, for instance, "recipe" information (which will be further discussed below) and may control batch processing
- the Batch Historian (BHIST) 306 records and stores batch-related data from the system 300
- the Continuous Historian (PI- PHIST) 308 records and stores continuous plant data from the system 300
- each of the Terminal Servers (TS) 310, 312, and 314 may be a host for remote access sessions for thin client terminals, such as desktop computers and tablet computers
- each of the controllers 316, 318, and 320 is a system device that may execute and run algorithms and/or set of executable instructions used to control the various equipment and functionalities.
- any one of the illustrated components in Figure 3 may be (or correspond to) one or more of the computer 120, server computer 130, mobile computer 140, smartphone device 150, tablet computer 160, and the storage device 170.
- the controllers 316, 318, and 320 which may be hardware, implement one or more control modules, which may be software, to control one or more control loops, which control the various field devices of the system 300 illustrated in Figure 3, such as various sensors, probes, actuators, pumps, agitators, monitors, etc., via the control modules.
- Figure 4 illustrates a flow diagram 400 of a titration recipe and parameter
- a "recipe" may be a combination or a set of instructions for executing certain tasks associated with an external analytics system. And each instruction of the instruction set can execute a step of a particular process.
- recipes may be uniquely built by users and/or operators from scratch for different types of processes and tasks. Alternatively, they can also be readily available or pre-programmed recipes. As will be described below, certain parameters may be tagged for extraction as the instructions of the recipe are executed. The tagging process may also be implemented from scratch by the users and/or operators.
- Figure 4 a recipe for performing titration for a bioreactor tank is shown.
- the bioreactor tank may be the tank for media preparation or the tank for buffer preparation in the PWCS shown in Figure 2.
- the titration recipe may be stored the Batch Executive (EXEC) 304, as described above in Figure 3, and executed by one or more terminals, such as computer 120.
- EXEC Batch Executive
- the titration recipe may include a set of at least six different instructions.
- instruction 402 allows a pH meter or sensor in the tank to be turned on (if the pH meter is not already turned on).
- instruction 404 allows the measurement of the initial volume of titrant being used.
- one or more pH values may be measured before the titrant is added to the medium in the bioreactor tank.
- instruction 408 the titrant is added to the medium in the bioreactor tank.
- one or more pH values may be continuously measured.
- a pH value may be incrementally measured at every "X" volume measurement of titrant that is added into the medium until all of the titrant has been added. Subsequently, instruction 412 allows the measurement of one or more pH values after the addition of the titrant into the medium.
- the user and/or operator may build the titration recipe differently than the above described recipe, e.g., as simple or complex as the user and/or operator desires.
- Figure 4 also shows an example of parameter "tagging" in accordance with aspects of the invention.
- pH values of the medium in the bioreactor tank prior to, during, and after the titration process may be of interest for further analysis.
- the users and/or operators that build the titration recipe may also implement into the one or more individual instructions "tags" for any parameters of interest.
- Tag 1 may be implemented with instruction 406 and configured to extract a hundred consecutively measured pH values before titrant is added to the medium.
- Tag 2 may be implemented with instruction 406, but may be configured to extract the remaining volume measurements of titrant at each of the hundred pH value measurements associated with Tag 1.
- the remaining volume of titrant should all be the same at each pH measurement since the titrant has not yet been added to the medium (e.g., the "add titrant" instruction has not yet been executed).
- Tag 3 may be implemented with instruction 410 and configured to extract measured pH values at "X" volume increments (e.g., 2 mL) of the titrant until all of the titrant has been added into the medium. For example, there may be a hundred increments, which may equate to a hundred pH readings.
- Tag 4 may also be implemented with instruction 410 and configured to extract the remaining volume measurements of the titrant at every pH reading. For example, the remaining volume at each pH measurement should continually decrease as more and more titrant is added to the medium.
- Tag 5 similar to Tag 1, extracts a hundred consecutively measured pH values after all of the titrant has been added to the medium in the bioreactor tank, but associated with instruction 412.
- Tag 6 configured to extract the remaining volume measurements of the titrant, all of which should be zero or approximately zero. It may be understood by those of ordinary skill in the art that not all of the above described tags 1-6 are necessary and that one or more of them may be selected in different combinations in additional embodiments.
- Figure 4 illustrates a titration recipe associated with a bioreactor tank
- parameter tagging may be applied to different types of recipes associated with all sorts of components of a system, such as instructions for controlling sensors with transmitters, scales, switches, pumps, control valves, discrete valves, pumps with fixed-speed starters or variable frequency drives, agitators with variable frequency drives, discrete valves with limit switches, etc.
- data acquired for parameter tagging may not originate from the system component itself, such as the bioreactor tank, transmitters, scales, switches, etc., as set forth above, but there may be instances when an operator may perform a manual activity and enter the data into the system.
- Figure 5 illustrates an example database table 500 in accordance with one or more aspects of the present invention.
- the database table 500 may include all of the extracted or “pushed" parameters that have been previously tagged for extraction or “pushing out,” which may be output to the database table 500 during and/or after the execution of the titration recipe shown in Figure 4.
- the local memory of the one or more computing devices, as illustrated in Figures 2 and/or 3 for instance, may store the database table 500.
- the database table 500 may also reside in a separate database for further data retrieval and analysis.
- the parameters may be pushed out to a messaging queue for continued processing, which may then be collected and packaged into a particular format (e.g., database table 500, xml format, etc.).
- the parameters and the metadata associated with the parameters automatically can be formatted in any fashion.
- Figure 5 illustrates a table, but the extracted information may be organized and/or summarized in any suitable format.
- the parameters and/or the metadata in accordance with one or more aspects of the disclosure, may be selectable (e.g., in real-time as the recipe is still being executed, after the aggregation of the data), as presented in the above-described format.
- the database table 500 may have three rows, each row containing the parameters corresponding to their respective instructions (e.g., instruction 406, instruction 410, instruction 412, etc.). Moreover, the database table may also include five columns: the first column specifies the specific instruction in the titration recipe illustrated in Figure 4, the second column contains the extracted pH parameters for each of the instructions, the third column indicates the remaining volume measurement of the titrant for each of the instructions, the fourth column specifies the exact time the measurements were taken for each of the instructions, and the fifth column shows any relevant information, context, metadata, etc.
- the first column specifies the specific instruction in the titration recipe illustrated in Figure 4
- the second column contains the extracted pH parameters for each of the instructions
- the third column indicates the remaining volume measurement of the titrant for each of the instructions
- the fourth column specifies the exact time the measurements were taken for each of the instructions
- the fifth column shows any relevant information, context, metadata, etc.
- a user may be able to select any information in the database table 500, such as the "bioreactor tank 206" text, in which the computing device may display that the tank is currently part of the MES system 200, as illustrated in Figure 2, and/or the user may also be able to select the actual parameters.
- the user may be presented with relatable and important information (such as operator comments, notes, etc.) helpful for further analysis of the information.
- the middle row (corresponding to instruction 410) may be populated with the same.
- "X' amount of the titrant is added to the medium at a time, then it will take a total of a hundred times to add all of the titrant to the medium.
- a pH reading is taken using the pH meter or sensor, e.g., pH values 101 to 200 in Figure 5 represent these readings.
- the remaining volume of titrant after adding the first "X" amount will be the initial volume minus "X,” which corresponds to pH Value 101.
- the exact time of each measurement is also recorded.
- each measurement is taken every second.
- contextual information may be provided, such as the identification information associated with the bioreactor tank, the name of the control system the tank is associated with, where the tank is geographically located (e.g., that the tank is located at the "Location A" facility), etc., as described above.
- Other various parameters may similarly be populated in the database table 500, as above and as shown in Figure 5.
- information in the database table 500 may be stored in a separate database.
- the information is easily accessible by users and/or operators for further analysis (e.g., examining and using the titration results for other types of requisite procedures in the bioreactor system, ensuring the titration results are within predetermined limits, etc.) and not scattered across different storage devices in the system database.
- parameter tagging also allows for the unique identification and extraction of all parameters that are of interest with contextual information (e.g., metadata) that is useful and applicable, which is otherwise not possible in a pull procedure.
- Figure 6 illustrates a flow diagram 600 in accordance with one or more aspects of the present invention.
- the flow diagram 600 includes steps for identifying, extracting, and outputting certain information (e.g., parameters) in relatable form along with context corresponding to the extracted information based on the parameter tagging procedure described above.
- the steps of the flow diagram 600 may be executed on one or more computing devices, such as computer 120 of Figure 1.
- a computing device may execute a recipe for a component of an external analytics system, where the recipe may be the above-described titration recipe and the component may be the above-described bioreactor tank.
- the recipe may be the above-described titration recipe and the component may be the above-described bioreactor tank.
- numerous types of information and data may be collected at step 604, of which some may be of interest.
- the computing device determines which data from the collected data (e.g., data related to a batch process) are identified for extraction (or pushing out). The determination is based at least in part on the tagging process, which may have been already built into the recipe by a user and/or operator. Moreover, it may be understood that the determination may be made during or otherwise after the execution of the recipe.
- the data or parameters that are tagged as information of interest are subsequently extracted.
- the extracted data is output to a separate database and/or a messaging queue for transmittal to the separate database and/or middleware.
- the separate database may be stored in local memory of the computing device executing the recipe and/or the separate database of the system.
- the aggregated data in the separate database may be accessed for further processing by any user and/or operator from any geographical location at any time. For example, an operator located in one geographical location may easily access the pH values prior to, during, and after titration of the medium in the bioreactor tank located in a differing geographical location in real-time.
- the systems, devices, facilities, and/or methods described herein are suitable for use in and with culturing any desired cell line including prokaryotic and/or eukaryotic cell lines. Further, the systems, devices, facilities, and/or methods described herein allow for the production of eukaryotic cells, prokaryotic cells and/or products of the eukaryotic or prokaryotic cells, e.g., proteins, peptides, antibiotics, amino acids, nucleic acids (such as DNA or RNA), synthesized by the eukaryotic cells in a large-scale manner. [0044] In one embodiment, the eukaryotic cells are mammalian cells.
- the mammalian cells can be for example human or rodent or bovine cell lines or cell strains.
- Examples of such cells, cell lines or cell strains include, for example, mouse myeloma (NSO)-cell lines, Chinese hamster ovary (CHO)-cell lines, HT1080, H9, HepG2, MCF7, MDBK Jurkat, NIH3T3, PC 12, BHK (baby hamster kidney cell), VERO, SP2/0, YB2/0, Y0, C127, L cell, COS, e.g., COS1 and COS7, QCl-3,HEK-293, VERO, PER.C6, HeLA, EB1, EB2, EB3, oncolytic or hybridoma-cell lines.
- NSO mouse myeloma
- CHO Chinese hamster ovary
- the mammalian cells are CHO-cell lines.
- the cell is a CHO cell.
- the cell is a CHO-K1 cell, a CHO-K1 SV cell, a DG44 CHO cell, a DUXBl l CHO cell, a CHOS, a CHO GS knock-out cell, a CHO FUT8 GS knock-out cell, a CHOZN, or a CHO-derived cell.
- the CHO GS knock-out cell e.g., GSKO cell
- the CHO FUT8 knockout cell is, for example, the Potelligent® CHOK1 SV (Lonza Biologies, Inc.).
- the eukaryotic cells are stem cells.
- the stem cells can be, for example, pluripotent stem cells, including embryonic stem cells (ESCs), adult stem cells, induced pluripotent stem cells (iPSCs), tissue specific stem cells (e.g., hematopoietic stem cells) and mesenchymal stem cells (MSCs).
- ESCs embryonic stem cells
- iPSCs induced pluripotent stem cells
- tissue specific stem cells e.g., hematopoietic stem cells
- MSCs mesenchymal stem cells
- the eukaryotic cell is a lower eukaryotic cell.
- the lower eukaryotic cell can be, for example, a yeast cell.
- yeast cells include, for example, Pichia genus (e.g. Pichia pastoris, Pichia methanolica, Pichia kluyveri, and Pichia angusta), Komagataella genus (e.g. Komagataella pastoris, Komagataella pseudopastoris or Komagataella phaffii), Saccharomyces genus (e.g.
- Pichia pastoris a species Pichia pastoris.
- Examples for Pichia pastoris strains are X33, GS115, KM71, KM71H; and CBS7435.
- the eukaryotic cell is a fungal cell.
- the fungal cell can be, for example, Aspergillus (such as A. niger, A. fumigatus, A. orzyae, A. nidula), Acremonium (such as A. therm ophilum), Chaetomium (such as C. therm ophilum), Chrysosporium (such as C. thermophile), Cordyceps (such as C. militans), Corynascus, Ctenomyces, Fusarium (such as F. oxysporum), Glomerella (such as G. graminicola), Hypocrea (such as H.
- Aspergillus such as A. niger, A. fumigatus, A. orzyae, A. nidula
- Acremonium such as A. therm ophilum
- Chaetomium such as C. therm ophilum
- Chrysosporium such as C. thermo
- M. orzyae such as M. orzyae
- Myceliophthora such as M. thermophile
- Nectria such as N. heamatococca
- Neurospora such as N. crassa
- Penicillium such as S. thermophile
- Thielavia such as T. terrestris, T. heterothallica
- Tnchoderma such as T. reesei
- Verticillium such as V. dahlia
- the eukaryotic cell is an insect cell (e.g., Sf9, MimicTM Sf9,
- BT1-TN-5B1-4 High FiveTM
- BT1-Ea88 cells an algae cell (e.g., of the genus Amphora, Bacillariophyceae, Dunaliella, Chlorella, Chlamydomonas, Cyanophyta (cyanobacteria), Nannochloropsis, Spirulina,or Ochromonas), or a plant cell (e.g., cells from monocotyledonous plants (such as maize, rice, wheat, or Setaria), or from a dicotyledonous plants (e.g., cassava, potato, soybean, tomato, tobacco, alfalfa, Physcomitrella patens or Arabidopsis).
- monocotyledonous plants such as maize, rice, wheat, or Setaria
- dicotyledonous plants e.g., cassava, potato, soybean, tomato, tobacco, alfalfa, Physcomitrella patens or Arabidopsis
- Eukaryotic cells can also be avian cells, cell lines or cell strains, for example,
- EBx ® cells such as EB14, EB24, EB26, EB66, or EBvl3.
- the prokaryotic cell is a Gram-positive cell such as Bacillus,
- Bacillus examples include B.subtilis, B.amyloliquefaciens, B.licheniformis, B.natto, or B.megaterium.
- the cell is B.subtilis, such as B.subtilis 3NA and B.subtilis 168.
- Bacillus is commercially available from the Bacillus Genetic Stock Center, Biological Sciences 556, 484 West 12 th Avenue, Columbus OH 43210-1214.
- the prokaryotic cell is a Gram-negative cell, such as
- Salmonella spp. or Escherichia coli including e.g., TGI, TG2, W3110, DH1, DHB4, DH5a, HMS 174, HMS174 (DE3), M533, C600, HBlOl, JM109, MC4100, XLl-Blue and Origami, as well as those derived from E.coli B -strains, such as BL-21 or BL21 (DE3), all of which are commercially available.
- the cell is a hepatocyte such as a human hepatocyte, animal hepatocyte, or a non-parenchymal cell.
- the cell can be a plateable metabolism qualified human hepatocyte, a plateable induction qualified human hepatocyte, plateable Qualyst Transporter CertifiedTM human hepatocyte, suspension qualified human hepatocyte (including 10-donor and 20-donor pooled hepatocytes), human hepatic kupffer cells, human hepatic stellate cells, dog hepatocytes (including single and pooled Beagle hepatocytes), mouse hepatocytes (including CD-I and C57BI/6 hepatocytes), rat hepatocytes (including Sprague-Dawley, Wistar Han, and Wistar hepatocytes), monkey hepatocytes (including Cynomolgus or Rhesus monkey hepatocytes), cat hepatocytes (including Domestic Shorthair
- the cell is a differentiated form of any of the cells described herein.
- the cell is a cell derived from any primary cell in culture. Suitable host cells are commercially available, for example, from culture collections such as the German Collection of Microorganisms and Cell Cultures GmbH (DSMZ) or the American Type Culture Collection (ATCC).
- the systems, devices, facilities, and/or methods described herein are suitable for culturing suspension cells or anchorage-dependent (adherent) cells.
- the systems, devices, facilities, and/or methods described herein can also be suitable for production operations configured for the production of pharmaceutical and biopharmaceutical products—such as polypeptide products, nucleic acid products (for example DNA or RNA), or cells and/or viruses such as those used in cellular and/or viral therapies.
- the systems, devices, facilities, and/or methods described herein can be used for producing biosimilars.
- the cultured cells express or produce a product, such as a recombinant therapeutic or diagnostic product.
- products produced by cells include, but are not limited to, antibody molecules (e.g., monoclonal antibodies, bispecific antibodies), antibody mimetics (polypeptide molecules that bind specifically to antigens but that are not structurally related to antibodies such as e.g., DARPins, affibodies, adnectins, or IgNARs), fusion proteins (e.g., Fc fusion proteins, chimeric cytokines), other recombinant proteins (e.g., glycosylated proteins, enzymes, hormones), viral therapeutics (e.g., anti-cancer oncolytic viruses, viral vectors for gene therapy and viral immunotherapy), cell therapeutics (e.g., pluripotent stem cells, mesenchymal stem cells and adult stem cells), vaccines or lipid-encapsulated particles (e.g.
- molecules having a molecular weight of about 4000 daltons to greater than about 140,000 daltons can be produced.
- these molecules can have a range of complexity and can include posttranslational modifications including glycosylation.
- the protein is, e.g., BOTOX, Myobloc, Neurobloc, Dysport (or other serotypes of botulinum neurotoxins), alglucosidase alpha, daptomycin, YH-16, choriogonadotropin alpha, filgrastim, cetrorelix, interleukin-2, aldesleukin, teceleulin, denileukin diftitox, interferon alpha-n3 (injection), interferon alpha-nl, DL-8234, interferon, Suntory (gamma- la), interferon gamma, thymosin alpha 1, tasonermin, DigiFab, ViperaTAb, EchiTAb, CroFab, nesiritide, abatacept, alefacept, Rebif, eptoterminalfa, teriparatide (osteoporosis), calcitonin injectable (bone disease), calc
- the polypeptide is adalimumab (HIJMIRA ® ), infliximab
- REMICADETM rituximab
- RITUXANTM/MAB THERATM etanercept
- ENBRELTM bevacizumab
- AVASTINTM trastuzumab
- HERCEPTINTM trastuzumab
- NEULASTATM pegrilgrastim
- the polypeptide is a hormone, blood clotting/coagulation factor, cytokine/growth factor, antibody molelcule, fusion protein, protein vaccine, or peptide, these and other exemplary products are shown in Table 2.
- TSH thyroid hormone
- IFNan3 Interferon-an3 Alferon N
- KGF growth factor
- Efalizumab (CD1 la mAb)
- Spider silk e.g., fibrion QMONOS
- the protein is multispecific protein, e.g., a bispecific antibody as shown in Table 3.
- the systems, devices, facilities, and/or methods described herein can also include any suitable unit operation and/or equipment not otherwise mentioned, such as operations and/or equipment for separation, purification, and isolation of such products.
- Any suitable facility and environment can be used, such as traditional stick-built facilities, modular, mobile and temporary facilities, or any other suitable construction, facility, and/or layout.
- modular clean- rooms can be used.
- the devices, systems, and methods described herein can be housed and/or performed in a single location or facility or alternatively be housed and/or performed at separate or multiple locations and/or facilities.
- the systems, devices, facilities, and/or methods can include any suitable reactor(s) including but not limited to stirred tank, airlift, fiber, microfiber, hollow fiber, ceramic matrix, fluidized bed, fixed bed, and/or spouted bed bioreactors.
- suitable reactor(s) including but not limited to stirred tank, airlift, fiber, microfiber, hollow fiber, ceramic matrix, fluidized bed, fixed bed, and/or spouted bed bioreactors.
- reactor can include a fermentor or fermentation unit, or any other reaction vessel and the term “reactor” is used interchangeably with “fermentor.”
- an example bioreactor unit can perform one or more, or all, of the following: feeding of nutrients and/or carbon sources, injection of suitable gas (e.g., oxygen), inlet and outlet flow of fermentation or cell culture medium, separation of gas and liquid phases, maintenance of temperature, maintenance of oxygen and C02 levels, maintenance of pH level, agitation (e.g., stirring), and/or cleaning/sterilizing.
- Example reactor units such as a fermentation unit, may contain multiple reactors within the unit, for example the unit can have 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 60, 70, 80, 90, or 100, or more bioreactors in each unit and/or a facility may contain multiple units having a single or multiple reactors within the facility.
- the bioreactor can be suitable for batch, semi fed-batch, fed-batch, perfusion, and/or a continuous fermentation processes. Any suitable reactor diameter can be used.
- the bioreactor can have a volume between about 100 mL and about 50,000 L.
- Non-limiting examples include a volume of 100 mL, 250 mL, 500 mL, 750 mL, 1 liter, 2 liters, 3 liters, 4 liters, 5 liters, 6 liters, 7 liters, 8 liters, 9 liters, 10 liters, 15 liters, 20 liters, 25 liters, 30 liters, 40 liters, 50 liters, 60 liters, 70 liters, 80 liters, 90 liters, 100 liters, 1501iters, 200 liters, 250 liters, 300 liters, 350 liters, 400 liters, 450 liters, 500 liters, 550 liters, 600 liters, 650 liters, 700 liters, 750 liters, 800 liters, 850 liters, 900 liters, 950 liters, 1000 liters, 1500 liters, 2000 liters, 2500 liters, 3000 liters, 3
- suitable reactors can be multi-use, single-use, disposable, or non- disposable and can be formed of any suitable material including metal alloys such as stainless steel (e.g., 316 L or any other suitable stainless steel) and Inconel, plastics, and/or glass.
- metal alloys such as stainless steel (e.g., 316 L or any other suitable stainless steel) and Inconel, plastics, and/or glass.
- the systems, devices, facilities, and/or methods can include any desired volume or production capacity including but not limited to bench-scale, pilot-scale, and full production scale capacities.
- tagging all of the parameters of interest when a particular recipe is built allows for the tagged parameters to be "pushed" to a messaging queue, one or more separate databases designated for such data, and/or middleware, rather than a user and/or operator "pulling" the parameters from various storage devices scattered across the system database.
- the information is easily, conveniently, and quickly accessible from any geographical location at any time in real-time (and not at a later time).
- information is pushed out with various contextual data, metadata, such as external analytics system information and other types of contextual data, allowing the information to be in more relatable form and also allowing user and/or operator to better perform analysis on the information, such as, selecting and analyzing the data presented to the user.
- the extracted information may reside in local memory of the computing device executing the recipe, which makes it unnecessary to perform database calls.
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- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Manufacturing & Machinery (AREA)
- Quality & Reliability (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Automation & Control Theory (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
- General Factory Administration (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims
Priority Applications (5)
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JP2019551360A JP2020513818A (en) | 2017-03-17 | 2018-03-15 | Automated batch data analysis |
EP18768745.4A EP3583510A4 (en) | 2017-03-17 | 2018-03-15 | Automated batch data analysis |
KR1020197030287A KR20190129092A (en) | 2017-03-17 | 2018-03-15 | Automated Batch Data Analysis |
CN201880018639.9A CN110419011A (en) | 2017-03-17 | 2018-03-15 | Automate batch data analysis |
IL26907019A IL269070A (en) | 2017-03-17 | 2019-09-02 | Automated batch data analysis |
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US201762472990P | 2017-03-17 | 2017-03-17 | |
US62/472,990 | 2017-03-17 |
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WO2018170281A1 true WO2018170281A1 (en) | 2018-09-20 |
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PCT/US2018/022661 WO2018170281A1 (en) | 2017-03-17 | 2018-03-15 | Automated batch data analysis |
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US (1) | US20180267516A1 (en) |
EP (1) | EP3583510A4 (en) |
JP (1) | JP2020513818A (en) |
KR (1) | KR20190129092A (en) |
CN (1) | CN110419011A (en) |
IL (1) | IL269070A (en) |
WO (1) | WO2018170281A1 (en) |
Citations (2)
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US6449624B1 (en) * | 1999-10-18 | 2002-09-10 | Fisher-Rosemount Systems, Inc. | Version control and audit trail in a process control system |
US20070198116A1 (en) * | 2004-05-06 | 2007-08-23 | Popp Shane M | Methods of performing path analysis on pharmaceutical manufacturing systems |
Family Cites Families (6)
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WO2009023659A1 (en) * | 2007-08-14 | 2009-02-19 | Shell Oil Company | System and methods for continuous, online monitoring of a chemical plant or refinery |
US20090089247A1 (en) * | 2007-09-28 | 2009-04-02 | Terrence Lynn Blevins | Methods and apparatus to standardize data properties in a process control environment |
US9117015B2 (en) * | 2008-12-23 | 2015-08-25 | Roche Diagnostics Operations, Inc. | Management method and system for implementation, execution, data collection, and data analysis of a structured collection procedure which runs on a collection device |
US9551983B2 (en) * | 2011-11-15 | 2017-01-24 | Rockwell Automation Technologies, Inc. | Activity set management in a Manufacturing Execution System |
US20140121789A1 (en) * | 2012-10-30 | 2014-05-01 | Rockwell Automation Technologies, Inc. | Advisable state of controlled objects in factory automation systems |
EP2871548B1 (en) * | 2013-11-06 | 2017-07-19 | Siemens Aktiengesellschaft | Method of producing a pharmaceutical product using a MES |
-
2018
- 2018-03-15 KR KR1020197030287A patent/KR20190129092A/en unknown
- 2018-03-15 CN CN201880018639.9A patent/CN110419011A/en active Pending
- 2018-03-15 EP EP18768745.4A patent/EP3583510A4/en not_active Withdrawn
- 2018-03-15 JP JP2019551360A patent/JP2020513818A/en not_active Withdrawn
- 2018-03-15 WO PCT/US2018/022661 patent/WO2018170281A1/en unknown
- 2018-03-16 US US15/923,799 patent/US20180267516A1/en not_active Abandoned
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2019
- 2019-09-02 IL IL26907019A patent/IL269070A/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6449624B1 (en) * | 1999-10-18 | 2002-09-10 | Fisher-Rosemount Systems, Inc. | Version control and audit trail in a process control system |
US20070198116A1 (en) * | 2004-05-06 | 2007-08-23 | Popp Shane M | Methods of performing path analysis on pharmaceutical manufacturing systems |
US20070288114A1 (en) * | 2004-05-06 | 2007-12-13 | Popp Shane M | Methods of integrating computer products with pharmaceutical manufacturing hardware systems |
Non-Patent Citations (1)
Title |
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See also references of EP3583510A4 * |
Also Published As
Publication number | Publication date |
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EP3583510A1 (en) | 2019-12-25 |
JP2020513818A (en) | 2020-05-21 |
KR20190129092A (en) | 2019-11-19 |
CN110419011A (en) | 2019-11-05 |
US20180267516A1 (en) | 2018-09-20 |
EP3583510A4 (en) | 2020-12-23 |
IL269070A (en) | 2019-11-28 |
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