WO2018085901A1 - A therapeutic device - Google Patents

A therapeutic device Download PDF

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Publication number
WO2018085901A1
WO2018085901A1 PCT/AU2017/051252 AU2017051252W WO2018085901A1 WO 2018085901 A1 WO2018085901 A1 WO 2018085901A1 AU 2017051252 W AU2017051252 W AU 2017051252W WO 2018085901 A1 WO2018085901 A1 WO 2018085901A1
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WO
WIPO (PCT)
Prior art keywords
phototherapeutic bandage
bandage
phototherapeutic
layer
light source
Prior art date
Application number
PCT/AU2017/051252
Other languages
French (fr)
Inventor
Raymond Dennis PALMER
Original Assignee
Helium 3 Resources Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2016904633 priority Critical
Priority to AU2016904633A priority patent/AU2016904633A0/en
Application filed by Helium 3 Resources Pty Ltd filed Critical Helium 3 Resources Pty Ltd
Publication of WO2018085901A1 publication Critical patent/WO2018085901A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/0616Skin treatment other than tanning
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0635Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645Applicators worn by the patient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0658Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0659Radiation therapy using light characterised by the wavelength of light used infra-red
    • A61N2005/066Radiation therapy using light characterised by the wavelength of light used infra-red far infrared

Abstract

A phototherapeutic bandage configured to conform to a surface area of a wearer. The bandage includes a first layer with an electroluminescent light source adapted to emit radiation to a portion of a target area of a user, and a second layer having a source configured to emit radiation at a wavelength in the far-infrared radiation range to the target area, or portion thereof.

Description

A THERAPEUTIC DEVICE

Field of the Invention

[1 ] The present disclosure relates to a therapeutic device. In particular, the present disclosure relates to a phototherapeutic bandage that includes an electroluminescent light source and a far infrared emitting source.

Summary of the Invention

[2] The following is a broad summary of various exemplary embodiments of a phototherapeutic bandage of the present disclosure. As such, it is provided solely for the purpose of enhancing the clarity of the specification. It is not intended to limit the scope of the appended claims.

[3] According to one broad aspect of the present disclosure, although not necessarily the broadest aspect, there is provided a phototherapeutic bandage capable of conforming to a surface area of a wearer. The phototherapeutic bandage comprises a first layer, the first layer including an electroluminescent light source configured to emit radiation to at least a portion of a target area of the wearer and a second layer, the second layer including a source configured to emit radiation at a wavelength in the far-infrared radiation range to the portion, or another portion of the target area of the wearer.

[4] The second layer may be configured to be intermediate the first layer and the wearer. The second layer may be configured to be intermediate the first layer and a surface of the wearer. The second layer may be configured to be intermediate the electroluminescent light source and the surface of the wearer.

[5] The source configured to emit radiation at a wavelength in the far-infrared radiation range may include a ceramic. The ceramic may be a particulate material. The ceramic material may be a powder. The particulate material may include a nanoparticle or a microparticle, or a combination thereof.

[6] The source configured to emit radiation at a wavelength in the far-infrared radiation range includes a fibre or a fabric. The fibre or the fabric is coated or impregnated with the ceramic particulate material. The fibre or the fabric may comprise a neoprene or a polyethylene terephthalate.

[7] The electroluminescent light source may be adapted to convert a direct current to an alternating current to thereby power the electroluminescent light source by the alternating current. The electroluminescent light source may further include a circuit converter to convert the direct current to the alternating current.

[8] The phototherapeutic bandage may further include a fastener or a strap. The phototherapeutic bandage may further include a flexible base layer. The flexible base layer may be integral with the first layer and/or the second layer.

[9] The electroluminescent light source may be integrated with the first layer. The electroluminescent light source may be fastened or attached to the first layer.

[10] In preferred embodiments, the electroluminescent light source may be configured to emit radiation at a wavelength between about 10 nanometres and about 1200 nanometres, about 100 nanometres and about 1 100 nanometres, more preferably about 400 nanometres and about 1000 nanometres, even more preferably between about 630 nanometres and about 790 nanometres and yet even more preferably, a wavelength selected from the group consisting of about 630 nanometres, about 653 nanometres, about 660 nanometres and about 750 nanometres, and any combination thereof. In certain preferred embodiments of any one of the aforementioned aspects, the electroluminescent light source may be configured to emit radiation at a wavelength between about 800 nanometres to about 1200 nanometres, and more preferably, about 830 nanometres.

[1 1 ] The electroluminescent light source may be a thin film electroluminescent source.

[12] The electroluminescent light source may be an electroluminescent panel. The electroluminescent panel may be a thin film electroluminescent panel.

[13] The wavelength in the far infrared radiation range may be between about 50 micrometres and about 1000 micrometres. The wavelength in the far infrared radiation range may be between about 3 micrometres to 100 micrometres.

[14] The phototherapeutic bandage may further include a control mechanism configured to control one or more parameters for operation of the electroluminescent light source and/or the source configured to emit radiation at a wavelength in the far- infrared radiation range. Suitable parameter/s may be an intensity of radiation, a frequency of radiation, a wavelength of radiation, a power density, a temperature of the target area, an application of voltage, and an exposure time, and any combination thereof. [15] The control mechanism may include a processor. The processor may be a microprocessor.

[16] The phototherapeutic bandage may further include a voltage source. The voltage source may be a battery. The battery may be rechargeable.

[17] The phototherapeutic bandage may further include a voltage source monitoring arrangement for monitoring the voltage source.

[18] The phototherapeutic bandage may further include a transmitter for transmitting signals to a remote terminal. The transmitter may be a wireless transmitter.

[19] The phototherapeutic bandage may further include a receiver configured for receiving signals from a remote terminal. The receiver may be a wireless receiver.

[20] The phototherapeutic bandage may further include a timing circuit configured to stop the electroluminescent light source after a predetermined amount of elapsed time.

[21 ] According to another broad aspect of the present disclosure, although not necessarily the broadest aspect, there is provided a method of a treating or ameliorating a symptom associated with a disease, disorder or condition in a subject in need thereof, the method including: contacting a target area of the subject with the phototherapeutic bandage of the aforementioned aspect; and delivering radiation to at least a portion of the target area, wherein delivery of the radiation includes transmitting radiation from the phototherapeutic bandage to the at least a portion of the target area to thereby treat or ameliorate the symptom of the disease, disorder or condition in the subject.

[22] According to yet another broad aspect of the present disclosure, although not necessarily the broadest aspect, there is provided a method of delivering radiation to a subject in need thereof using the phototherapeutic bandage of the aforementioned aspect.

[23] In preferred embodiments, the subject may be a mammal. More preferably, the mammal may be a human.

[24] The methods of present disclosure may treat a dermal wound. The dermal wound may be a breached dermis. The dermal wound may be an ulcer. [25] It will be appreciated that reference herein to "preferred" or "preferably" is intended as exemplary only.

[26] Ranges are to be interpreted as being fully inclusive of endpoints and all values between the limits.

Detailed Description of the Invention

[27] The present disclosure, is directed at least in part, to a phototherapeutic bandage capable of conforming to a surface area of a wearer or a subject in need of phototherapeutic treatment. The term "bandage" as used herein includes

conventional bandages, wrap-type bandages, band aids and pressure wraps, although without limitation thereto. The phototherapeutic bandage of the present disclosure includes a first layer comprising an electroluminescent light source configured to emit radiation to at least a portion of a target area of the wearer; and a second layer, the second layer comprising a source configured to emit radiation at a wavelength in the far-infrared radiation range to the portion, or another portion of the target area of the wearer. It will be appreciated that in preferred embodiments, the phototherapeutic bandage so arranged is capable of administering radiation or light at a plurality of wavelengths to thus potentially therapeutically or prophylactically treat one or more conditions, diseases, or disorders in a subject in need thereof.

[28] The phototherapeutic bandage is configured to conform to a surface area of the wearer. The phototherapeutic bandage may be configured to conform to a target area of the wearer. The phototherapeutic bandage of the present disclosure may be configured to be wearable. The phototherapeutic bandage may be sized and configured to receive a body part of a wearer, for example an arm, a hand, or a leg or a wearer (although without limitation thereto). Accordingly, the phototherapeutic bandage and layers of the phototherapeutic bandage, may be formed from any suitable material, or a combination of materials. The phototherapeutic bandage may have a plurality of layers formed from the same or different materials. A particular advantage of plurality of layers formed of different materials is that the materials in each layer may have the same or different properties. The phototherapeutic bandage and/or layers thereof may be formed from a flexible material including, but not limited to, a polymer, a plastics material, a fibre such a cotton and the like. The

phototherapeutic bandage and/or layers thereof may be formed a material with elastic properties, which may be particularly advantageous in situations where the phototherapeutic bandage is designed to remain attached to the wearer without use of additional attachment aids such as straps, fasteners and the like. The phototherapeutic bandage may include a flexible base layer that may be formed from a suitably flexible material capable of conforming to the wearer. The material of the flexible base layer may include a biocompatible polymer or a plastics material. The flexible base layer may be integral with the first layer and/or the second layer. In certain embodiments, the flexible base layer may be the first layer or the second layer. It will be appreciated that the first layer and/or the second layer may extend continuously across the phototherapeutic bandage. Alternatively, the first layer and/or layer may be a portion of the phototherapeutic bandage. The portion of the first layer may or may not, fully or partially overlap the second layer and vice versa.

[29] The phototherapeutic bandage may include a layer to assist with gas transfer such as a semi-permeable layer. The phototherapeutic bandage may include a foam and in particular a pliable foam. The foam may be covered by a suitable covering material that provides strength, durability and/or rigidity such as neoprene, although without limitation thereto. The phototherapeutic bandage may include an adhesive layer to attach the phototherapeutic bandage to a wearer. The phototherapeutic bandage of the present disclosure may be configured such that the wearer is able to attach the bandage or indeed, the bandage may be attached to the wearer by an individual other than the wearer. The phototherapeutic bandage may be attached or coupled to a wearer by a strap, a fastener, a strap or an adhesive layer.

[30] The phototherapeutic bandage comprises a first layer which includes an electroluminescent light source configured to emit radiation to at least a portion of a target area of a wearer. Preferably, the electroluminescent light source is a flexible device that may conform to the surface area of a wearer. The electroluminescent light source may be integrally incorporated into the first layer of the phototherapeutic bandage. Alternatively, the electroluminescent light source may be fastened, attached or otherwise coupled to the first layer of the phototherapeutic bandage by a fastening means such as an adhesive, a hook-and-loop arrangement (e.g., Velcro) or a hook-and-eye arrangement, although without limitation. The electroluminescent light source may extend continuously across at least a portion, or the entirety of the first layer.

[31 ] The first layer and in particular, the electroluminescent light source may be in direct or indirect contact with a wearer. The first layer and in particular, the electroluminescent light source of the first layer, may be separated from the target area of the wearer by a layer of material such as moisture barrier (e.g., a plastics material) or a layer to minimise any excessive heat transfer from the light source to the target area. In certain preferred embodiments, the first layer consists or consists essentially of the electroluminescent light source. The phototherapeutic bandage may be configured such that the first layer and in particular, the electroluminescent light source of the first layer, may be separated from the target area or a surface of the wearer by the second layer. Accordingly, the second layer may be intermediate the first layer and a surface, and preferably an exposed surface such as a target area, of the wearer. It is envisaged that the second layer may be intermediate the electroluminescent light source and a surface, and preferably an exposed surface such as a target area, of the wearer. The second layer may contact the surface of the wearer. In certain embodiments, the second layer may contact the surface of wearer whilst the electroluminescent light source is prevented from contact the surface of the wearer by either the second layer, or another layer such as the flexible base layer or a moisture retentive layer although without limitation thereto. The first layer may be at least partially or may be entirely within, encased, housed or coated with the second layer.

[32] Exemplary embodiments of the present disclosure may include use of alternating current ("AC") voltage to perform high speed flickering to excite the cellular metabolism with spectral agitation, which in turn places the cell into an excited state and not just an elevated state, to thus provide a therapeutic benefit. In certain embodiments, the therapeutic benefit may be an improvement in wound healing. Although not wishing to be bound by any particular theory, exemplary embodiments of the phototherapeutic bandage of the present disclosure are particularly amenable to emitting light onto open wounds or injuries deeper inside the human body to increase cellular metabolism, create an anti-inflammatory response and remove bacteria, although without limitation thereto. In preferred embodiments, the phototherapeutic bandage may use an electroluminescent light source that oscillates AC voltage back and forth (creating a sinusoidal waveform) to illuminate a phosphor panel in an electroluminescent light device to thereby create light or radiation at a desired wavelength. In certain embodiments, the electroluminescent light source as used herein excludes light emitting diodes ("LED"). In certain embodiments, the phototherapeutic bandage, and in particular the

electroluminescent light source, may use DC voltage

[33] The electroluminescent light source may be a formed from a material capable of producing radiation at a desired wavelength. The electroluminescent light source may include or be formed from a luminescent polymer. The electroluminescent light source may include powder or thin films. The electroluminescent light source in the form of a panel is particularly preferred as the flexibility of the panel assists with conforming to the surface area of the wearer. Other non-panel arrangements of the electroluminescent light source are also contemplated.

[34] It will be appreciated that the choice of electroluminescent layers, dopants, phosphors and other materials for inclusion in the electroluminescent light source may be somewhat dependent upon one or more factors such as application and desired wavelength. The electroluminescent active layer of the electroluminescent light source may include an organic-based material or an inorganic-based material, as is known in the art. The present disclosure also contemplates use of an electroluminescent light source in the form of a high field electroluminescent device. The electroluminescent light source may be a thin film electroluminescence ("TFEL") device.

[35] In preferred embodiments, the electroluminescent light source may be a panel, and in particular, a TFEL panel. An electroluminescent panel and in particular a TFEL panel is particularly advantageous as it provides uniform illumination over the target treatment area without the use of diffusers. It is envisaged that this overcomes at least one disadvantage of LED technology. LED technology prevents an even illumination of light and create intense points of light and heat. Although not wishing to be bound by any particular theory, a non-limiting advantage of an

electroluminescent panel is one point of light, that is the entire panel surface is the light source. A TFEL panel may be an organic- and inorganic-based

electroluminescence source.

[36] The electroluminescent light source may be capable of emitting radiation at different wavelengths, such as all wavelengths from visible light, including red light, infrared light (including near-infrared) and ultraviolet light. It will be appreciated that the choice of wavelength may be dependent, at least in part, on the depth of the targeted treatment area. Generally, although not exclusively, shorter wavelengths of less than or equal to about 700 nanometres (nm) are used to treat superficial tissue whereas wavelengths above about 700 nm penetrate further and are typically used to treat deeper tissue. It will be appreciated that typically, although not exclusively, Blue light of about 400 nm to about 470 nm has depth of light penetration of <1 mm; Blue - green light between about 475 nm to about 545 nm has depth of 0.3 to 0.5 mm; Yellow light of about 570 nm to about 590 nm has a depth of 0.5 mm to 2 mm; red light of about 630 nm to about 790 nm has depth of 2 to 3 mm and near infra-red of about 800 nm to about 1200 nm has a depth of 5 mm to 10 mm. In general, preferred embodiments, the wavelength may be in the range between about 10 nm to about 1200 nm. Preferably, the radiation is light in the visible range of the electromagnetic spectrum. In preferred embodiments, the wavelength of the radiation is between about 100 nm and about 1000 nm, between about 400 nm and about 1000 nm, more preferably about 630 nm to about 1200 nm, even more preferably about 630 nm to about 790 nm. In other preferred embodiments about 800 nm to about 1200 nm. In preferred embodiments, a wavelength is selected from the group consisting of about 630 nm, about 653 nm, about 660 nm, about 750 nm and about 830 nm, and any combination thereof.

[37] According to certain preferred embodiments, the phototherapeutic device of the present disclosure may include an electroluminescent light source adapted to convert a direct current to an alternating current to thereby power the electroluminescent light source by the alternating current. The electroluminescent light source may further include a circuit converter to convert the direct current to the alternating current. For example, using a standard 9-volt DC battery and an oscillation circuit using a 555 timer Integrated Circuit (IC), a micro step up transformer to emit 25 volts in AC or any AC voltage up to 230 volts may be used. Voltage may not be adjustable by the user or wearer. Accordingly, the voltage may be set in the factory during the

manufacturing process.

[38] The phototherapeutic bandage includes a second layer comprising a source configured to emit radiation at a wavelength in the far-infrared radiation ("FIR") range to at least a portion the target area of the wearer. The FIR source may extend continuously across at least a portion, or alternatively the entirety, of the second layer. An FIR source may be arrayed or arranged at a plurality of discrete areas on or within the second layer. The FIR range may include a wavelength between about 50 micrometres and about 1000 micrometres. The FIR range may suitably include a wavelength between about 3 micrometres and about 100 micrometres. Although not wishing to bound by any particular theory, the phototherapeutic bandage of the present disclosure may utilise non-heating FIR for therapeutic purposes, in which the bandage generates FIR from the heat emitted from the wearer's body. The thermal black body radiation may stay trapped in the target are due, at least in part, to the non-radiating properties of the phototherapeutic bandage. This thermal black body radiation may activate thermoreceptors present in the target area, which in turn may activate downstream therapeutic pathways. [39] The source configured to emit FIR may be any material as known to a person of skill in the art. The material may be a ceramic and may be preferably a bio- ceramic. The ceramic may be a substantially pure or homogenous material, or may be a combination of compounds to form a suitable ceramic. The ceramic may comprise a mineral such as a sericite mineral (a fine grained mica) or a boron-silicate mineral, although without limitation thereto. The ceramic may be a solid form, or alternatively a powdered form. By way of example, a solid form of a ceramic may be a disc or other suitable shape. In preferred embodiment, the ceramic is a particulate material. The ceramic may be a nanoparticle or a microparticle, or any combination thereof.

[40] The source configured to emit FIR may be a fibre or a fabric material. The fibre or fabric material may have at least one other property such as flexibility or be resistant to fluid. Non-limiting examples of suitable fabrics or materials include a neoprene or a polyethylene terephthalate. The fibre or fabric may further comprise a FIR-emitting compound. For example, the fibre or fabric be impregnated with, or coated with a ceramic particulate material. Celliant (Hologenix, USA) is a non-limiting example of a polyethylene terephthalate fibre material that incorporates FIR emitting ceramic nanoparticles that may be suitable for the present disclosure.

[41 ] The phototherapeutic bandage of the present disclosure is preferably configured to emit radiation to at least a portion of a target area of the wearer. The target area of a wearer is typically an area that requires therapeutic treatment. It will be appreciated that at least a portion, or alternatively the entire, target area may be treated. The target area may be breached skin such as a wound. The wound may be a chronic, non-healing wound (e.g., a venous leg ulcer, a pressure ulcer, a friction ulcer, a diabetic foot ulcer), or alternatively, the wound may be an acute wound. The target area may be non-breached or intact skin that requires treatment of a dermal skin condition such as eczema, rosacea and psoriasis, although without limitation thereto. The target area may also include sub-dermal conditions that require therapy such as a tissue injury or a bruise. Indications included may be odema, tinea, baldness hair regrowth, acne vulgaris, ring worm, dermatitis, eczma, psoriasis, fungal skin infections, scars, stretchmarks, warts, acne, acne scars, roseola, chickenpox, measles, cold sore or herpes, hives, vitiligo, necrotizing fasciitis, cutaneous candidiasis, carbuncle, cellulitis, hypohidrosis or anhidrosis, impetigo, cutis laxa, decubitis ulcer, erysipelas, canker sore, fungal nail infections, dermatomyositis, molluscum contagiosum, sebaceous cysts, seborrheic keratosis, pilonidal sinus, keloid scars, lichen planus, actinic keratosis, stasis dermatitis and leg ulcers, corns and calluses, tinea versicolor, pemphigoid, shingles, diabetic ulcers, pressure sores, arthritis, torn muscles, torn ligaments, torn tendons, tendonitis and cancer.

[42] The area targeted or desired for treatment with radiation emitted from the electroluminescent light source and the FIR-emitting source may be the same, different or partially overlap.

[43] The electroluminescent light source and FIR-emitting source contemplated for use in the present invention may be configured to emit radiation at one or more desired wavelengths. The phototherapeutic bandage may emit light or radiation continuously or intermittently, or both. The duration of radiation emission may be dependent on the type of therapy being applied to the wearer or subject.

[44] The present disclosure contemplates phototherapeutic bandages and methods of using such bandages to irradiate a target area that uses a single wavelength (monotherapy) as well irradiating a target area with a combination of different wavelengths (so called 'combination treatment'). Combination treatment may be useful to target various depths of tissue. Although the wavelengths are different in a combination treatment modality, other parameters such as dose, fluence, power density, pulse structure and timing may be the same or different. Such parameters will depend on the application, as will be known by a person of skill in the art. By way of example, a combination treatment may comprise a wavelength from the red spectra and a wavelength from the near infra-red at the same or different fluence, dose, power density, pulse structure and timing. A treatment regime may include a single exposure or alternatively, a treatment course of over a number of hours, days or weeks, as is required.

[45] The phototherapeutic bandage of the present disclosure may be used in photodynamic therapy of a condition, disease or disorder. According to these embodiments that contemplate photodynamic therapy, the phototherapeutic bandage may emit radiation to a target area to thereby activate a photosensitive drug.

[46] The therapy process may be controlled by control mechanism such as a processor and preferably a microprocessor that facilitates setting of treatment parameters such as dose, frequency, duration, intensity, modulation and repeat treatment timing.

[47] The phototherapeutic bandage may include a control mechanism configured to control one or more parameters for operation of the electroluminescent light source and/or the source configured to emit radiation at a wavelength in the far-infrared radiation range. The control mechanism may be programmable. The control mechanism may be a processor and more preferably, a microprocessor. The control mechanism may be capable of operating the phototherapeutic operations of the bandage in many ways. The processor may be integrated with a panel to select or set the protocols.

[48] The phototherapeutic bandage preferably includes a voltage source. The voltage source may be a battery. The battery may be coupled to the processor. The battery may or may not be rechargeable. The battery may be conventional. The battery may be flexible. The present disclosure envisages a plurality of batteries. In a preferred embodiment, the battery may be a built-in or integrated rechargeable battery with a Universal Serial Bus (USB) outlet, for example a 5-volt USB plug, that can be plugged into any PC or USB charger.

[49] The phototherapeutic bandage, and preferably the control mechanism, may also contain circuitry to control temperature of the wound so that the wound can be kept in a desired temperature range to facilitate healing.

[50] The phototherapeutic bandage may comprise digital storage media. The digital storage media may include instructions configured for instructing a controller configured for receiving signals, for example receiving signals from sensors.

[51 ] The phototherapeutic bandage may be configured to communicate wirelessly with another suitable electronic device. A suitable advantage of such an arrangement is that it permits communication with a smart phone, for example, to monitor how much treatment has taken place and at what intensities allows the wearer to monitor their progress, although without limitation thereto.

[52] A voltage source monitoring arrangement may be integrated with the phototherapeutic bandage. The voltage source monitor may be monitored by way of wireless communication.

[53] The phototherapeutic bandage may also communicate with external devices using a wire-based system. The phototherapeutic bandage may also include electrodes.

[54] The phototherapy bandage may include a timing circuit configured to stop emission of radiation after a predetermined amount of elapsed time. Such a timing circuit is particularly advantageous for a pulsed mode of operation. For example, a predetermined amount of elapsed period of time may be about 10 seconds, about 20 seconds, about 30 seconds, about 40 seconds, about 50 seconds, and about 60 seconds or more, 1 hour or 2 hours or more. The predetermined amount of elapsed time may be dependent on the therapeutic application.

[55] Methods of the present disclosure include methods of treating or ameliorating a symptom associated with a disease, disorder or condition. As used herein, the terms "treatment, " "treating, " and the like, refer to obtaining a desired pharmacologic and/or physiologic effect. The effect may be therapeutic in terms of a partial or complete remediation of a symptom. These terms also cover any treatment of a symptom in a subject and include: (a) inhibiting of the symptom, i.e., arresting its development; or (b) relieving the symptom, i.e., causing regression of symptom.

[56] The present disclosure contemplates methods, including therapeutic or prophylactic methods, that deliver or transmit radiation from the phototherapeutic bandage as described herein to a subject in need thereof. The electroluminescent light source and the FIR-emitting source may treat the same, or different conditions, diseases and/or disorders.

[57] The terms "patient", "subject" or "wearer", used interchangeably herein, refer to any subject, particularly a vertebrate subject, preferably an animal subject and even more particularly a mammalian subject, for whom therapy or prophylaxis is desired. Preferably, the mammalian subject is a human.

[58] It is will be appreciated that if the light or radiation applied is not of sufficient irradiance or the irradiation time is too short then there is no response. If the irradiance is too high or irradiation time is too long, then the response may be inhibited. Somewhere in between is the optimal combination of irradiance and time for stimulation. It will be appreciated that parameters such as duration of exposure (can be known as irradiation time), power of radiation (mW), energy (J) of radiation or light, suitable type of radiation source, number of treatments or exposures, treatment interval (hours, days or weeks), energy density (J/cm2), wavelength of radiation and depth of penetration of radiation is dependent, at least in part, upon the method being employed and as will be known by a person of skill in the art. Typically, although not exclusively, in those embodiments that contemplate low level light therapy, it uses relatively low fluences (between about 0.04 to about 50 J/cm2) and power densities (< 100 mW/cm2). Ranges are to be interpreted as being fully inclusive of all values between the limits. [59] The appended claims are to be considered as incorporated into the above description.

[60] Throughout the specification, including the claims, where the context permits, the term "comprising" and variants thereof such as "comprise" or "comprises" are to be interpreted as including the stated integer or integers without necessarily excluding any other integers. By "consisting of is meant including, and limited to, whatever follows the phrase "consisting of. Thus, the phrase "consisting of" indicates that the listed elements are required or mandatory, and that no other elements may be present. By "consisting essentially of is meant including any elements listed after the phrase, and limited to other elements that do not interfere with or contribute to the activity or action specified in the disclosure for the listed elements. Thus, the phrase "consisting essentially of indicates that the listed elements are required or mandatory, but that other elements are optional and may or may not be present depending upon whether or not they affect the activity or action of the listed elements.

[61 ] Various substantially and specifically practical and useful exemplary embodiments of the claimed subject matter, are described herein, textually and/or graphically, including the best mode, if any, known to the inventors for carrying out the claimed subject matter. Variations (e.g., modifications and/or enhancements) of one or more embodiments described herein might become apparent to those of ordinary skill in the art upon reading this application. The inventors expect skilled artisans to employ such variations as appropriate, and the inventors intend for the claimed subject matter to be practiced other than as specifically described herein. Accordingly, as permitted by law, the claimed subject matter includes and covers all equivalents of the claimed subject matter and all improvements to the claimed subject matter. Moreover, every combination of the above described elements, activities, and all possible variations thereof are encompassed by the claimed subject matter unless otherwise clearly indicated herein, clearly and specifically disclaimed, or otherwise clearly contradicted by context.

[62] Thus, regardless of the content of any portion (e.g., title, field, background, summary, description, abstract, drawing, figure, etc.) of this application, unless clearly specified to the contrary, such as via explicit definition, assertion, or argument, or clearly contradicted by context, with respect to any claim, whether of this application and/or any claim of any application claiming priority hereto, and whether originally presented or otherwise: a. there is no requirement for the inclusion of any particular described or illustrated characteristic, function, activity, or element, any particular sequence of activities, or any particular interrelationship of elements; b. no characteristic, function, activity, or element is "essential"; c. any elements can be integrated, segregated, and/or duplicated; d. any activity can be repeated, any activity can be performed by multiple entities, and/or any activity can be performed in multiple jurisdictions; and e. any activity or element can be specifically excluded, the sequence of activities can vary, and/or the interrelationship of elements can vary.

[63] The use of the terms "a", "an", "said", "the", and/or similar referents in the context of describing various embodiments (especially in the context of the following claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context. The terms "comprising," "having," "including," and "containing" are to be construed as open-ended terms (i.e., meaning "including, but not limited to,") unless otherwise noted.

[64] Moreover, when any number or range is described herein, unless clearly stated otherwise, that number or range is approximate.

[65] Accordingly, every portion (e.g., title, field, summary, description, drawings, etc.) of this application, other than the claims themselves, is to be regarded as illustrative in nature, and not as restrictive, and the scope of subject matter protected by any patent that issues based on this application is defined only by the claims of that patent.

Claims

What is claimed is:
1 . A phototherapeutic bandage capable of conforming to a surface area of a wearer, the phototherapeutic bandage comprising:
a first layer, the first layer including an electroluminescent light source configured to emit radiation to at least a portion of a target area of the wearer; and a second layer, the second layer including a source configured to emit radiation at a wavelength in the far-infrared radiation range to the portion, or another portion of the target area of the wearer.
2. The phototherapeutic bandage of claim 1 , wherein the second layer is configured to be intermediate the first layer and a surface of the wearer.
3. The phototherapeutic bandage of claim 1 or claim 2, wherein the second layer is configured to be intermediate the electroluminescent light source and the surface of the wearer.
4. The phototherapeutic bandage of any one of the aforementioned claims, wherein the source configured to emit radiation at a wavelength in the far-infrared radiation range includes a ceramic.
5. The phototherapeutic bandage of claim 4, wherein the ceramic is a particulate material.
6. The phototherapeutic bandage of claim 5, wherein the particulate material includes a nanoparticle or a microparticle, or a combination thereof.
7. The phototherapeutic bandage of any one of the aforementioned claims, wherein the source configured to emit radiation at a wavelength in the far-infrared radiation range includes a fibre or a fabric.
8. The phototherapeutic bandage of claim 7, wherein the fibre or the fabric is coated or impregnated with the ceramic particulate material.
9. The phototherapeutic bandage of claim 7 or claim 8, wherein the fibre or the fabric comprises a neoprene or a polyethylene terephthalate.
10. The phototherapeutic bandage of any one of the aforementioned claims, the electroluminescent light source being adapted to convert a direct current to an alternating current to thereby power the electroluminescent light source by the alternating current.
1 1 . The phototherapeutic bandage of claim 10, wherein the electroluminescent light source further includes a circuit converter to convert the direct current to the alternating current.
12. The phototherapeutic bandage of any one of the aforementioned claims, wherein the phototherapeutic bandage further includes a flexible base layer.
13. The phototherapeutic bandage of claim 12, wherein the flexible base layer is integral with the first layer and/or the second layer.
14. The phototherapeutic bandage of any one of the aforementioned claims, wherein the phototherapeutic bandage further includes a fastener or a strap.
15. The phototherapeutic bandage of any one of the aforementioned claims, wherein the electroluminescent light source is integrated with, or fastened to the first layer.
16. The phototherapeutic bandage of any one of the preceding claims, wherein the electroluminescent light source is configured to emit a wavelength between about 10 nanometres and about 1200 nanometres.
17. The phototherapeutic bandage of claim 16, wherein the electroluminescent light source is configured to emit a wavelength between about 400 nanometres and about 1000 nanometres.
18. The phototherapeutic bandage of claim 17, wherein the electroluminescent light source is configured to emit a wavelength between about 630 nanometres and about 790 nanometres.
19. The phototherapeutic bandage of claim 16, wherein the electroluminescent light source is configured to emit a wavelength between about 800 nanometres to about 1200 nanometres.
20. The phototherapeutic bandage of any one of the preceding claims, wherein the electroluminescent light source is a thin film electroluminescent source.
21 . The phototherapeutic bandage of any one of the preceding claims, wherein the electroluminescent light source is an electroluminescent panel.
22. The phototherapeutic bandage of claim 21 , wherein the electroluminescent panel is a thin film electroluminescent panel.
23. The phototherapeutic bandage of any one of the preceding claims, wherein the wavelength in the far-infrared radiation range is between about 50 micrometres and about 1000 micrometres.
24. The phototherapeutic bandage of any one of the preceding claims, further including a control mechanism configured to control one or more parameters for operation of the electroluminescent light source and/or the source configured to emit radiation at a wavelength in the far-infrared radiation range.
25. The phototherapeutic bandage of claim 24, wherein the one or more parameters are selected from the group consisting of an intensity of radiation, a frequency of radiation, a wavelength of radiation, a power density, a temperature of the target area, an application of voltage, and an exposure time, and any
combination thereof.
26. The phototherapeutic bandage of claim 24 or claim 26, wherein the control mechanism includes a processor.
27. The phototherapeutic bandage of any one of the preceding claims, further including a voltage source.
28. The phototherapeutic bandage of claim 27, wherein the voltage source includes a battery.
29. The phototherapeutic bandage of claim 28, wherein the battery is rechargeable.
30. The phototherapeutic bandage of any one of claims 28 to 30, which further includes a voltage source monitoring arrangement for monitoring the voltage source in operation.
31 . The phototherapeutic bandage of any one of the preceding claims, further including a transmitter for transmitting signals to a remote terminal.
32. The phototherapeutic bandage of claim 31 , wherein the transmitter is a wireless transmitter.
33. The phototherapeutic bandage of any one of the preceding claims, further including a receiver configured for receiving signals from a remote terminal.
34. The phototherapeutic bandage of claim 33, wherein the receiver is a wireless receiver.
35. A method of treating or ameliorating a symptom associated with a disease, disorder or condition in a subject in need thereof, the method including: contacting a target area of the subject with a phototherapeutic bandage as claimed in any one of claims 1 to 34; and delivering radiation to at least a portion of the target area, wherein delivery of the radiation includes transmitting radiation from the phototherapeutic bandage to the at least a portion of the target area to thereby treat or ameliorate the symptom of the disease, disorder or condition in the subject.
36. A method of delivering radiation to a subject in need thereof using the phototherapeutic bandage as claimed in any one of claims 1 to 34.
37. The method of claim 35 or claim 36, wherein the subject is a mammal.
38. The method of claim 37, wherein the mammal is a human.
39. The method of any one of claims 35 to 38, wherein the disease, disorder or condition is a dermal wound.
PCT/AU2017/051252 2016-11-14 2017-11-14 A therapeutic device WO2018085901A1 (en)

Priority Applications (2)

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AU2016904633 2016-11-14
AU2016904633A AU2016904633A0 (en) 2016-11-14 A Therapeutic Device

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Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000015296A1 (en) * 1998-09-11 2000-03-23 Light Sciences Corporation Conformal patch for administering light therapy to subcutaneous tumors
US20040111132A1 (en) * 2002-12-10 2004-06-10 Olga Shenderova Phototherapeutic treatment methods and apparatus
US20050256654A1 (en) * 2000-04-06 2005-11-17 European Molecular Biology Laboratory Computer controlled microscope
WO2007050144A1 (en) * 2005-10-28 2007-05-03 United Laboratories & Manufacturing, Llc Hygienic-therapeutic multiplex devices
WO2007054855A1 (en) * 2005-11-11 2007-05-18 Koninklijke Philips Electronics N.V. Device for use in phototherapy
US20070239232A1 (en) * 2006-03-28 2007-10-11 Eastman Kodak Company Light guide based light therapy device
JP2013062200A (en) * 2011-09-15 2013-04-04 Konica Minolta Holdings Inc Portable light emitting instrument
CN202875607U (en) * 2012-11-12 2013-04-17 陆建国 Nano ceramic powder adhesive bandage with far infrared heating function
WO2014000039A1 (en) * 2012-06-29 2014-01-03 Resmed Limited Pressure sensor evaluation for respiratory apparatus
WO2014023918A1 (en) * 2012-08-07 2014-02-13 Bioenergy Research Center Multilayer dermal device, transmitter or reflector of far infrared radiation, in particular for medical purposes, and patch or item comprising said multilayer
US20140276247A1 (en) * 2013-03-15 2014-09-18 Sonovia Holdings Llc Light and ultrasonic transducer device
CN104207888A (en) * 2013-05-31 2014-12-17 天津法莫西医药科技有限公司 Medical dressing coated with far infrared material layer
CN204181787U (en) * 2014-09-11 2015-03-04 天津法莫西医药科技有限公司 Novel medical dressing for wrists

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000015296A1 (en) * 1998-09-11 2000-03-23 Light Sciences Corporation Conformal patch for administering light therapy to subcutaneous tumors
US20050256654A1 (en) * 2000-04-06 2005-11-17 European Molecular Biology Laboratory Computer controlled microscope
US20040111132A1 (en) * 2002-12-10 2004-06-10 Olga Shenderova Phototherapeutic treatment methods and apparatus
WO2007050144A1 (en) * 2005-10-28 2007-05-03 United Laboratories & Manufacturing, Llc Hygienic-therapeutic multiplex devices
WO2007054855A1 (en) * 2005-11-11 2007-05-18 Koninklijke Philips Electronics N.V. Device for use in phototherapy
US20070239232A1 (en) * 2006-03-28 2007-10-11 Eastman Kodak Company Light guide based light therapy device
JP2013062200A (en) * 2011-09-15 2013-04-04 Konica Minolta Holdings Inc Portable light emitting instrument
WO2014000039A1 (en) * 2012-06-29 2014-01-03 Resmed Limited Pressure sensor evaluation for respiratory apparatus
WO2014023918A1 (en) * 2012-08-07 2014-02-13 Bioenergy Research Center Multilayer dermal device, transmitter or reflector of far infrared radiation, in particular for medical purposes, and patch or item comprising said multilayer
CN202875607U (en) * 2012-11-12 2013-04-17 陆建国 Nano ceramic powder adhesive bandage with far infrared heating function
US20140276247A1 (en) * 2013-03-15 2014-09-18 Sonovia Holdings Llc Light and ultrasonic transducer device
CN104207888A (en) * 2013-05-31 2014-12-17 天津法莫西医药科技有限公司 Medical dressing coated with far infrared material layer
CN204181787U (en) * 2014-09-11 2015-03-04 天津法莫西医药科技有限公司 Novel medical dressing for wrists

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