WO2018076231A1 - 一种卫生棉条 - Google Patents

一种卫生棉条 Download PDF

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Publication number
WO2018076231A1
WO2018076231A1 PCT/CN2016/103547 CN2016103547W WO2018076231A1 WO 2018076231 A1 WO2018076231 A1 WO 2018076231A1 CN 2016103547 W CN2016103547 W CN 2016103547W WO 2018076231 A1 WO2018076231 A1 WO 2018076231A1
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Prior art keywords
sensor
tampon
test strip
chip
filter
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PCT/CN2016/103547
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English (en)
French (fr)
Inventor
李鹏
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广州悦鸿方生物科技有限公司
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Priority to PCT/CN2016/103547 priority Critical patent/WO2018076231A1/zh
Publication of WO2018076231A1 publication Critical patent/WO2018076231A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/20—Tampons, e.g. catamenial tampons; Accessories therefor

Definitions

  • the invention relates to a tampon, in particular to a tampon which collects or can detect the physiological and biochemical indexes of menstrual blood in situ and in real time.
  • Sampling and diagnosis of gynecological disease detection is damaging, time lag and dependent on hospitals and health care providers.
  • blood is taken for damage, blood components, various detection markers, cells, etc. are used for diagnosis.
  • pathological examination invasive biopsy is performed on cancer tissues. And detection and analysis of cell levels with or without abnormalities.
  • the detection of urine, feces, saliva, etc. is limited by the sampling location, test location and inspectors.
  • Menstruation is the periodic detachment of the endometrium with bleeding.
  • the main component of menstrual blood is blood.
  • it contains fragments of endometrium, cervical mucus, vaginal epithelial cells, various active enzymes and biological factors. Therefore, menstrual blood is an ideal sample for tumor markers or other disease diagnosis.
  • Tampons can be placed in the vagina to absorb menstrual blood when women have menstrual cramps. Because they are dry and comfortable, they are not easy to leak, and super suction is popular abroad.
  • the tampon has a larger amount of menstrual blood absorption than the sanitary napkin and is smaller in size.
  • the tampon is placed in the vagina to absorb menstrual blood and has a certain isolation from the external environment. Therefore, the tampon is more suitable for collecting and analyzing menstrual blood. a.
  • the function of the tampon is limited to the absorption of menstrual blood. No tampon can enrich or detect the physiological and biochemical indicators in the menstrual blood to detect the physiological state and health of women.
  • the object of the present invention is to provide a tampon of a load detecting device capable of detecting physiological and biochemical indexes in menstrual blood in situ, in real time and on-line, thereby predicting/diagnosing a physiological state and a healthy state of a woman.
  • Another object of the present invention is to provide a tampon containing an enrichment device for collecting menstrual blood and further analyzing by third party instruments to confirm the occurrence of the disease.
  • the present invention provides a tampon comprising an absorbent body and a tampon drawing line, and the tampon is also loaded with a detecting device and/or an enriching device.
  • the detecting device is one or a combination of a physical detecting device, a chemical detecting device, or a biological detecting device.
  • the detecting device is one of a test strip, an intelligent sensing device or a combination thereof.
  • the test strip is a test strip which can be in the prior art, such as a dry biochemical test strip, a blood five test strip, a whole blood urea biosensor test strip, a trace element test strip, an HIV test strip, and the like. One or several. It can also be a test strip prepared by yourself.
  • the test strip is located in the absorbent body of the tampon, and has an inlet at an upper end thereof and an injection port at an insertion end of the tampon.
  • the entire test strip is in a sealed state except for the inlet and the drawing, to prevent the menstrual blood in the tampon from affecting the detection reaction.
  • the menstrual blood contacts the inlet of the test strip, and through capillary action, enters the detection zone and displays the result. After the tampon is taken out, the test strip is taken out through the test strip and the test result can be observed.
  • the intelligent sensing device is located in the absorbent body of the tampon.
  • the intelligent sensing device includes a sensor, a wireless signal transmission device, and a power supply device.
  • the smart sensing device is further provided with a filtering device above the filtering device, and the sensor is arranged under the filtering device to remove tissue debris and other impurities through the blood filtering device, and then contacts the sensor, and the sensor will pass the physical, chemical and biological signals in the blood. Converted into an electrical signal, the wireless signal transmission device transmits the electrical signal to the electronic device, and the software of the electronic device analyzes and processes the electrical signal to finally obtain the physiological and biochemical indicators of the female.
  • the senor is a MEMS sensor.
  • MEMS is a Micro-ElectroMechanical System.
  • Micro-electro-mechanical systems are micro-devices that can be mass-produced, integrating micro-mechanisms, micro-sensors, micro-actuators, and signal processing and control circuits, up to interfaces, communications, and power supplies. Or system.
  • the MEMS sensor is one or more of a MEMS physical sensor, a MEMS chemical sensor, and a MEMS biosensor.
  • the MEMS sensor is a microfluidic chip.
  • Microfluidics Chip integrates basic operation units such as sample preparation, reaction, separation, and detection in biological, chemical, and medical analysis processes into one micron.
  • a network is formed by the microchannel to control the microfluidics throughout the system, and the entire process of analysis is automatically completed.
  • VCSEL thin-film micro-vertical surface-emitting laser
  • Si-PD silicon photodiode
  • the senor is one or more of a physical sensor, a chemical sensor, and a biosensor.
  • the physical sensor is one or more of a humidity sensor, a temperature sensor, a thermal sensor, a weight sensor, and a volume sensor.
  • the chemical sensor is an ion sensitive sensor, a gas sensor, and a pH sensor.
  • the biosensor is one or more of a microbial sensor, an immunosensor, a tissue sensor, a cell sensor, an enzyme sensor, a nucleic acid sensor, and a protein sensor.
  • physiological and biochemical indicators in the menstrual blood can be detected.
  • the physiological and biochemical indicators detected include, but are not limited to, tissue cells in the menstrual blood, microorganisms such as bacteria, fungi and viruses, proteins such as tumor markers, HPV antigens and enzymes, trace elements, pH, hormones, menstrual blood volume, etc. One or more.
  • the invention detects that the physiological and biochemical indicators are one or more of tumor markers, such as C12 tumor markers, and the C12 tumor markers are specifically alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA). , neuron-specific enolase (NSE), glycogen 125 (CA125), glycogen 153 (CA153), glycogen 242 (CA242), glycogen 199 (CA199), prostate specific antigen (PSA), free prostate Specific antigen (f-PSA), ferritin (FER), ⁇ -human chorionic gonadotropin ( ⁇ -HCG), human growth hormone (HGH).
  • tumor markers such as C12 tumor markers
  • C12 tumor markers are specifically alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA).
  • AFP alpha-fetoprotein
  • CEA carcinoembryonic antigen
  • NSE neuron-specific enolase
  • glycogen 125 CA125
  • glycogen 153 glycogen 153
  • CA242 glyco
  • the physiological and biochemical indicators detected by the invention are one or several of the six sex hormones.
  • the six hormones are specifically FSH (follicle stimulating hormone), LH (luteinizing hormone), PRL (prolactin), E2 (estradiol), PROG (progesterone), T (testosterone).
  • the physiological and biochemical indicators detected by the present invention are one or several of the five thyroid gland, specifically triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH).
  • FT3 triiodothyronine
  • FT4 free thyroxine
  • TSH thyroid stimulating hormone
  • Thyroid peroxidase antibody (TPOAb) Thyroid peroxidase antibody
  • TGAb thyroglobulin antibody
  • the physiological and biochemical indicators detected by the invention are six pituitary bodies.
  • the sensor can be a sensor in the prior art or a sensor designed by itself.
  • the sensors in the prior art are the enzyme sensors, immunosensors, bacteria which have been commercialized or experimentally reported as reported in the document "Ren Shu. Biosensors and Sensors [J]. Instrument Technology and Sensors, 1987, 3:00. Sensors and other biosensors. Further examples are the multi-purpose enzyme sensor of Provesta corp. in the United Kingdom; the B.O.D sensor of Japan Rouge; the fluorescence polarization immunosensor of Abbot Laboratories (determination of total estriol in plasma).
  • the senor is a protein sensor.
  • the protein sensor comprises a protein chip.
  • Protein chip is a kind of immobilized probe protein (which can be antigen, according to a pre-designed method on the surface of solid support (filter, gel, slide, nanobead, microplate, polymer material, etc.). Antibodies, receptors, ligands, enzymes, substrates, etc.). The protein molecule with a special label (such as a fluorescent dye label) is incubated with the chip, and the probe can bind to and bind to the test protein (such as tumor marker, HPV antigen, etc.) in the sample, and then mark the label. The object is tested.
  • a special label such as a fluorescent dye label
  • protein chips there are many types of protein chips to choose from, such as nano-array immunochips, liquid chips, surface-enhanced laser desorption/ionization chips, surface plasmon resonance detection chips, isotope-labeled detection chips, fluorescent label detection chips, chemiluminescence detection chips, Enzyme immunolabeling detection chip, colloidal gold labeling detection chip, optical interference film chip, and the like.
  • the protein chip of the present invention is a chip for chemiluminescence detection.
  • the antibody binds to horseradish peroxidase or alkaline phosphatase
  • the enzyme binds to the luminescent agent, catalyzes and decomposes the luminescent agent, and produces an extended diffused light line, which is read by the optical quantum.
  • the system receives, the photomultiplier tube converts the optical signal into an electrical signal and amplifies it.
  • Chemiluminescence has the specificity of fluorescence, and does not require excitation light, avoids the influence of excitation light and stray light in fluorescence analysis, and has high sensitivity.
  • the protein sensor of the present invention contains a chemiluminescent detection protein chip and a photoelectric converter and signal amplifier.
  • the protein chip of the present invention is a fluorescent label detection chip.
  • FIG. 8 An exemplary detection principle of the fluorescent labeling detection chip is shown in FIG. 8: the solid phase antibody-fluorescent labeling antibody in the blood-contacting antigen-contacting chip forms a "solid phase antibody-test antigen-fluorescent labeling antibody" sandwich structure.
  • the immune complex under the illumination of the excitation light, the fluorescently labeled antibody fluoresces, and then the fluorescent signal is accepted and converted into an electrical signal, and then the electrical signal is analyzed.
  • the protein sensor comprises a protein chip, an excitation light source, a dichroic filter, a lens, a photoelectric converter, and a signal amplifier.
  • the protein chip is located below the filtering device; the protein chip, the dichroic filter, the lens and the photoelectric converter are sequentially in the same straight line; the photoelectric converter is connected to the signal amplifier through the circuit.
  • the protein chip is fixed with a probe capable of specifically reacting with the substance to be tested, and the blood contact protein chip filtered by the filtering device, the antigen to be tested and the like are specifically combined with the fluorescently labeled probe in the protein chip, and the excitation light is excited. Fluorescence is emitted under illumination.
  • the test substance is one or more of a C12 tumor marker, an HPV antigen, and the like.
  • the protein chip is a transparent material, and the protein chip emits fluorescence through the bottom of the chip.
  • the protein chip is a permeable filter that is permeable to blood to the side close to the photoelectric converter for reaction.
  • the excitation light source emits excitation light, which is reflected by the dichroic filter to the protein chip, and the labeled substance which specifically binds in the excitation protein chip emits fluorescence, and the emitted fluorescence is transmitted through the dichroic filter, and is collected by the lens to the photoelectric a converter that converts an optical signal into an electrical signal, amplifies it by a signal amplifier, and transmits it to the outside through a wireless signal transmission device.
  • Electronic equipment emits excitation light, which is reflected by the dichroic filter to the protein chip, and the labeled substance which specifically binds in the excitation protein chip emits fluorescence, and the emitted fluorescence is transmitted through the dichroic filter, and is collected by the lens to the photoelectric a converter that converts an optical signal into an electrical signal, amplifies it by a signal amplifier, and transmits it to the outside through a wireless signal transmission device.
  • Electronic equipment emits excitation light, which is reflected by the dichroic filter to the protein chip,
  • the wireless signal transmission device is selected from a WiFi chip, a Bluetooth chip, an RIFD chip or other wireless technology communication chip.
  • the power supply device is a micro battery or the like.
  • the power supply unit supplies power to the sensor and the wireless signal transmission device, and can share a power supply device or be used separately.
  • the sensor and the wireless signal transmission device share a power supply device, which saves space and realizes miniaturization of the smart sensor device.
  • the electronic device is a smart phone, a computer, a tablet, or the like.
  • the enrichment device is located in the absorbent body of the tampon.
  • the enrichment device is a conduit that is open at the upper end and closed at the lower end. The opening is located at the insertion end of the tampon, and there is a movable baffle below the opening.
  • the baffle is opened under the action of blood gravity, and when no menstrual blood flows in, the baffle is in a closed state.
  • At the lower end of the enrichment device there is also an enrichment device drawing line for the extraction of the enrichment device.
  • the enrichment device can enrich tissue cells, blood cells, secretions, and the like in women's menstrual blood. After the enrichment is completed, the enrichment device is split, and the third-party related instruments and technical means are further analyzed to confirm the physiological and biochemical indicators in the female menstrual blood, thereby detecting or confirming the occurrence of the disease.
  • the present invention is the first to load a detecting device in a tampon to achieve a real-time test of menstrual blood.
  • the sanitary article of the present invention integrates sample collection, detection, and data processing and processing, and can be used to receive detection data through an electronic device only when used during menstruation.
  • the tampon of the present invention can also be provided with a detachable enrichment device, which can enrich the cells and body fluids in the menstrual blood, and further pass third-party related instruments and technical means (such as Quantitative PCR and ELISA, etc., to confirm and confirm various physiological and biochemical indicators, and to improve the accuracy of disease prediction and diagnosis.
  • a detachable enrichment device which can enrich the cells and body fluids in the menstrual blood, and further pass third-party related instruments and technical means (such as Quantitative PCR and ELISA, etc., to confirm and confirm various physiological and biochemical indicators, and to improve the accuracy of disease prediction and diagnosis.
  • FIG. 1 is a schematic view of a tampon containing a test strip according to a first embodiment of the present invention
  • FIG. 2 is a schematic view of a tampon with an intelligent sensing device according to a second embodiment of the present invention
  • FIG. 3 is a schematic diagram of an intelligent sensing device according to Embodiment 2 of the present invention.
  • Figure 4 is a schematic view of the protein sensor in the second embodiment of the present invention.
  • FIG. 5 is a schematic view of a tampon containing an enrichment device according to a third embodiment of the present invention.
  • FIG. 6 is a schematic view of a tampon including an enrichment device and an intelligent sensing device according to Embodiment 4 of the present invention.
  • Figure 7 is a schematic diagram of the principle of chemiluminescence detection
  • Figure 8 is a schematic diagram of the detection principle of a fluorescent label
  • Example 1 A tampon containing a test strip
  • the tampon shown in Fig. 1 comprises an absorbent body 1 and a tampon drawing line 2, and the absorbent body 1 is internally provided with a test strip 3 (in the present example, the test strip 3 is an HIV test strip) ).
  • the test strip 3 has an inlet 31 at the top, the inlet 31 is located at the insertion end 11 of the tampon, and a test area 32 is present in the middle of the test strip 3, and the detection area 32 can display the detection result.
  • the entire test strip 3 is separated from the injection port 31 and the test strip drawing line 33, and the structure of the test strip 3 in the absorbent body 1 is in a sealed state to prevent the menstrual blood in the absorbent body 1 from affecting the detection reaction.
  • test strip drawing 33 for the extraction of the test strip 3.
  • the menstrual blood contacts the inlet of the test strip 3, and by capillary action, enters the detection zone 33 to react and display the result.
  • the test strip 3 is taken out through the test strip drawing line 33, and the test result can be observed.
  • the tampon containing the test strip of the invention carries out the detection of HIV without being restricted by the location, has no damage, and is convenient for timely detection of diseases, and has important application value.
  • the tampon of the present invention can also load other prior art test strips. Article, or a test strip made by yourself.
  • Embodiment 2 A tampon with an intelligent sensing device
  • the tampon shown in FIG. 2 comprises an absorbent body 1 and a tampon extraction line 2, and the absorption body 1 is internally provided with an intelligent sensing device 4, and the intelligent sensing device 4 is connected to the electronic device 6 by a wireless signal. .
  • the smart sensor device 4 is provided with a filter device 41 (in the present embodiment, a filter), a sensor 42, a wireless signal transmission device 43, and a power supply device 44.
  • the sensor 42 may be one or more of the prior art biological, physical, and chemical sensors, for example, one or more of the prior art enzyme sensors, immunosensors, bacterial sensors, and the like.
  • the sensor 42 is connected to the wireless signal transmission device 43 via a circuit.
  • the wireless signal transmission device 43 transmits the electrical signal to the electronic device 6 through electromagnetic waves, and the electronic device 6 analyzes the software to obtain physiological and biochemical indicators in the menstrual blood.
  • the electronic device 6 is a mobile phone, a computer, a tablet, etc. (in the embodiment, the electronic device is a mobile phone, and the physical health condition can be viewed online in real time).
  • the power supply unit 44 is connected to the sensor 42 and the wireless signal transmission unit 43 via a circuit.
  • the power supply device 44 is a micro battery.
  • the protein sensor comprises a protein chip 421, an excitation light source 422, a dichroic filter 423, a lens 424, a photoelectric converter 425, and a signal amplifier 426.
  • the protein chip 421 is located below the filter device 41.
  • a probe capable of specifically reacting with the substance to be tested is immobilized in the protein chip, and the blood contact protein chip 421 filtered by the filtering device 41, the antigen to be detected and the like are specifically bound to the fluorescently labeled probe in the protein chip, and are excited. Fluorescence is emitted by the illumination of light.
  • the test substance is one or more of a C12 tumor marker, an HPV antigen, and the like.
  • the protein chip 421 is a transparent material, and excitation light and fluorescence can pass through the bottom of the chip.
  • the dichroic filter 423 is located below the protein chip 421 at the same horizontal level as the excitation light source 422.
  • the excitation light source 422 emits excitation light
  • the dichroic filter 423 reflects the excitation light to the protein chip 421, and the excitation-specific labeling substance emits fluorescence, and the emitted fluorescence is transmitted through the dichroic filter.
  • the excitation light source is a violet LED.
  • the lens 444 is located below the dichroic filter 423, and concentrates the fluorescence transmitted through the dichroic filter 423 to the photoelectric converter 425 and the signal amplifier 426.
  • the photoelectric converter 425 and the signal amplifier 426 are connected to the wireless signal transmission device 43 by a circuit.
  • the amplified electrical signal is sent to the electronic device 6 through the wireless signal transmission device 43.
  • the electronic device is equipped with corresponding software, and the processing and analysis of the collected data is analyzed by the software, thereby finally realizing the health status of the tester online and in real time.
  • the tampon containing the intelligent sensing device can detect early, assist diagnosis, analyze the course of disease, guide treatment, monitor recurrence or metastasis, judge prognosis, etc. by detecting tumor markers, especially gynecological tumor markers and HPV antigens. .
  • Example 3 A tampon containing an enrichment device
  • the tampon shown in FIG. 5 comprises an absorbent body 1 and a tampon drawing line 2, and the absorption body 1 is internally provided with an enrichment device 5, the lower end of the enrichment device 5 is closed, and the upper end has an opening 51, and the enrichment device 5 Below the opening 51, a movable baffle 52 is provided.
  • the baffle 52 When flowing through the blood flow inlet port 51 into the enrichment device 5, the baffle 52 is opened under the action of blood gravity. When no menstrual blood flows in, the baffle 52 is closed. .
  • the lower end of the enrichment device 5 also has an enrichment device extraction line 53 for facilitating the extraction of the enrichment device 5.
  • the enrichment device 5 can enrich tissue cells, blood cells, secretions, and the like in female menstrual blood. After the enrichment is completed, the enrichment device 5 is split, and the physiological and biochemical indicators in the menstrual blood of the female are further detected or confirmed by third-party related instruments and technical means, thereby detecting the occurrence of the disease.
  • Embodiment 4 A tampon containing an enrichment device and an intelligent sensing device
  • the tampon shown in Figure 6 is provided with an intelligent sensing device 4 and an enrichment device 5.
  • Example 2 was repeated for the smart sensing device, and Example 3 was repeated for the enrichment device.

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Abstract

一种卫生棉条，其负载有智能传感装置(4)、试纸条(3)或富集装置(5)中的一种或几种。智能传感装置(4)中含有传感器(42)、无线信号传输装置(43)和供电装置(44)。传感器(42)可以将在经血中检测到的物理、化学、生物的信号转化为电信号，无线信号传输装置(43)将电信号发射到电子设备(6)，电子设备(6)的软件对电信号数据进行分析处理，最终得出女性的生理生化指标。富集装置(5)可以收集经血，进一步通过第三方仪器检测生理生化指标，提高疾病诊断的准确性。该卫生棉条可以集经血收集和检测一体，可实现实时、在线、无损伤性检测女性的生理生化指标。

Description

一种卫生棉条 技术领域
本发明涉及一种卫生棉条，尤其涉及一种收集或可原位、实时在线检测经血生理生化指标的卫生棉条。
背景技术
妇科疾病检测的取样和诊断具有损伤性，时间滞后性和依赖于医院和医护人员。如在生化学及生物学的检验过程中，做损伤性的取血，以血液成分、各种检测标记物、细胞等做诊断，在病理检验中，对癌组织等做损伤性的活组织检查及检测分析细胞水平有无异常。另外，在有关尿、粪便、唾液等方面的检测，受取样地点、测试地点和检查人员限制。
妇科肿瘤检测的取样和诊断，更是如此。然而，女性特异性高发肿瘤，如卵巢癌、子宫癌、宫颈癌及乳腺癌，因其诊断滞后、致死率高，在全球范围内一直是危害女性健康和生命的一类致死性疾病；因此，及早对包括妇科肿瘤的疾病进行预测、诊断，对女性健康和生活质量的维护和提高意义重大。但是，由于女性疾病的羞涩和难言之隐，患者直至患病严重才去医院看病，此时，可能已经错过疾病的最佳治疗时间。
虽然，某些妇科肿瘤的诊断已不具损伤性，如宫颈癌的检测，通过HPV(人乳头瘤病毒)检测和巴氏涂片，然而，这两种检测均需要患者到诊所采集样品，且具一定的侵入性，给患者造成不适感。
因此，发展一种无侵入性、损伤性、时间依赖性、地点依赖性、检测人员依赖性，能够提前诊断疾病，尤其是妇科肿瘤的检测装置具有十分重要的意义。
月经是子宫内膜周期性脱落并伴出血。经血的主要成分是血液，此外，还含有子宫内膜的碎片、宫颈黏液、阴道上皮细胞和各种活性酶及生物因子等。因此，经血是肿瘤标志物或是其他疾病诊断的理想样品。
卫生棉条在女性月经来潮时，可置入阴道中吸收经血，因其干爽舒适、不易泄露、超强吸力在国外备受欢迎。卫生棉条的经血吸收量比卫生巾大，体积更小巧，再加上卫生棉条是置入阴道中吸收经血，与外界环境具有一定的隔绝，因此卫生棉条更适于作为采集和分析经血的载体。
然而，目前为止，卫生棉条的功能仅仅限于吸收经血，没有一款卫生棉条可富集或是检测分析经血中的生理生化指标，来检测女性生理状态和健康状况。
发明内容
本发明的目的在于提供一种负载检测装置的卫生棉条，能够原位、实时、在线检测经血中的生理生化指标，从而预测/诊断女性的生理状态、健康状况。
本发明的目的还在于提供一种含有富集装置为卫生棉条，可收集经血，进一步通过第三方仪器分析，确证疾病的发生。
本发明的目的通过以下技术手段实现：
本发明提供了一种卫生棉条，含有吸收体和卫生棉条抽线，卫生棉条中，还负载有检测装置和/或富集装置。
所述的检测装置为物理检测装置、化学检测装置、或生物检测装置中的一种或组合。
优选地，所述的检测装置为试纸条、智能感应装置中的一种或其组合。
所述的试纸条为可以是现有技术中的试纸条，如干式生化检测试纸条、血五项试纸、全血尿素生物传感试纸、微量元素测定试纸、HIV试纸等中的一种或几种。也可以是自己设计制备的试纸条。
在本发明一优选的实施例中，所述的试纸条位于卫生棉条的吸收体中，其上端有一进样口，进样口位于卫生棉条的插入端。试纸条/试纸条上有一检测区，检测区可显示检测结果。试纸条底部有一抽线，用于试纸条/试纸条的抽出。作为优选的实施方式，整个试纸条除进样口和抽线，其余结构处于密封状态，以防止卫生棉条中的经血影响检测反应。使用时，经血接触试纸条的进样口，通过毛细作用，进入检测区反应并显示结果。抽出卫生棉条后，再通过试纸条抽线抽出试纸条，即可观察检测结果。
所述的智能传感装置位于卫生棉条的吸收体中。智能传感装置包含传感器、无线信号传输装置和供电装置。
优选地，所述的智能传感装置上方还设有一过滤装置，过滤装置下方为传感器，经血经过滤装置除去组织碎片及其他杂质，然后接触传感器，传感器将经血中的物理、化学、生物的信号转化为电信号，无线信号传输装置将电信号发射到电子设备，电子设备的软件对电信号进行分析处理，最终得出女性的生理生化指标。
优选地，所述的传感器为MEMS传感器。
MEMS是微型电子机械系统(Micro-ElectroMechanicalSystem)，微机电系统是指可批量制作的，将微型机构、微型传感器、微型执行器以及信号处理和控制电路、直至接口、通信和电源等于一体的微型器件或系统。
所述的MEMS传感器为MEMS物理传感器、MEMS化学传感器和MEMS生物传感器中的一种或几种。
或者优选地，所述的MEMS传感器为微流控芯片。微流控芯片(Microfluidics Chip)是把生物、化学、医学分析过程的样品制备、反应、分离、检测等基本操作单元集成到一块微米 尺度的芯片上，由微通道形成网络，以控制微流体贯穿整个系统，自动完成分析全过程。
作为可选择的微流控芯片的例子，如美国南加州大学的研究人员采用异质整合薄膜微型垂直腔面发射镭射器(VCSEL)与硅光电子二极体(Si-PD)的方式设计的完全封装的软性微流控荧光传感器。
优选地，所述的传感器为物理传感器、化学传感器和生物传感器中的一种或几种。
所述的物理传感器为湿度传感器、温度传感器、热敏传感器、重量传感器和体积传感器中的一种或几种。
所述的化学传感器为离子敏传感器、气敏传感器、pH传感器。
所述的生物传感器为微生物传感器、免疫传感器、组织传感器、细胞传感器、酶传感器、核酸传感器、蛋白质传感器中的一种或几种。
通过在智能传感装置中设置不同的传感器，可以对经血中各种生理生化指标进行检测。所检测的生理生化指标包括但不限于经血中的组织细胞，微生物如细菌、真菌和病毒，蛋白质如肿瘤标志物、HPV抗原和酶等，微量元素，pH，激素，月经血量等等中的一种或多种。
作为一种实施方案，本发明检测为生理生化指标为肿瘤标志物，例如C12肿瘤标志物中的一种或几种，C12肿瘤标志物具体为甲胎蛋白(AFP)、癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、糖原125(CA125)、糖原153(CA153)、糖原242(CA242)、糖原199(CA199)、前列腺特异性抗原(PSA)、游离前列腺特异性抗原(f-PSA)、铁蛋白(FER)、β-人绒毛膜促性腺激素(β-HCG)、人生长激素(HGH)。
作为一种实施方案，本发明检测的生理生化指标为性激素六项中一项或几项。激素六项具体为FSH(促卵泡激素)、LH(促黄体生成素)、PRL(催乳素)、E2(雌二醇)、PROG(孕酮)、T(睾丸酮)。
作为一种实施方案，本发明检测的生理生化指标为甲状腺五项中的一项或几项，具体为三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)。
作为一种实施方案，本发明检测的生理生化指标为脑垂体六项。
所述的传感器可以为现有技术中的传感器或者自己设计的传感器。
现有技术中的传感器如文献《任恕.生物敏感元件及传感器[J].仪表技术与传感器,1987,3:006.》中报道的已经商业化或实验成功的酶传感器、免疫传感器、细菌传感器等等生物传感器。更进一步的例子如英国Provesta corp.的多用途酶传感器；日本胭脂的B.O.D传感器；英国Abbot实验室的荧光偏振免疫传感器(测定血浆中的总雌三醇)等。
在本发明一优选的实施例中，所述的传感器为蛋白质传感器。
所述的蛋白质传感器包含蛋白芯片。
蛋白芯片是一种在固相支持物(滤膜、凝胶、玻片、纳米微珠、微孔板、高分子材料等)表面按照预先设计的方法固定大量的探针蛋白(可以是抗原、抗体、受体、配体、酶、底物等)。将带有特殊标记(如荧光染料标记)的蛋白分子与该芯片进行孵育反应，探针可结合样品中的待测蛋白质(如肿瘤标记物、HPV抗原等)并与之结合，然后再对标记物进行检测。
可选择的蛋白芯片有多种类型，如纳米阵列免疫芯片、液态芯片、表面增强激光解吸/离子化芯片、表面等离子体共振检测芯片、同位素标记检测芯片、荧光标记检测芯片、化学发光检测芯片、酶免疫标记检测芯片、胶体金标记检测芯片、光学干涉膜芯片等。
作为一个示范性的例子，本发明的蛋白芯片为化学发光检测的芯片。
化学发光检测芯片的示范性的检测原理如图7所示：抗体结合辣根过氧化酶或碱性磷酸酶，酶结合发光剂，催化和分解发光剂，产生一个延长的散发光线，由光量子阅读系统接收，光电倍增管将光信号转化为电信号并加以放大。
化学发光具有荧光的特异性，同时不需要激发光，避免了荧光分析中激发光、杂散光的影响，有很高的灵敏度。
作为一个优选的实施例，本发明的蛋白质传感器含有化学发光检测的蛋白芯片和光电转化器和信号放大器。
作为一个示范性的例子，本发明的蛋白芯片为荧光标记检测芯片。
荧光标记检测芯片的示范性的检测原理如图8所示：经血中的待测抗原接触芯片中的固相抗体-荧光标记抗体，形成“固相抗体-待测抗原-荧光标记抗体”三明治结构的免疫复合体，在激发光的照射下，荧光标记抗体发出荧光，然后荧光信号被接受和转化为电信号，再对电信号进行分析处理。
作为一个优选的实施例，所述的蛋白质传感器含有蛋白芯片、激发光光源、二向色滤光片、透镜、光电转化器和信号放大器。
更进一步地，所述的蛋白芯片位于过滤装置的下方；所述的蛋白芯片、二向色滤光片、透镜和光电转化器依次处于同一条直线；光电转化器与信号放大器通过电路相连。
蛋白芯片中固定有能与待测物质特异性反应的探针，经过滤装置过滤的经血接触蛋白芯片，待测的抗原等与蛋白芯片中带荧光标记的探针特异性结合，在激发光的照射下发出荧光。所述的待测物质如C12肿瘤标志物、HPV抗原等中的一种或几种。作为优选的实施方式，所述的蛋白芯片为透明材质，蛋白芯片中发出荧光透过芯片底部。或者优选地，所述的蛋白芯片为可渗透性的滤膜，经血可渗透到靠近光电转化器的一面进行反应。
激发光光源发出激发光，经过二向色滤光片反射至蛋白芯片，激发蛋白芯片中特异性结合的标记物质发出荧光，发出的荧光再透射过二向色滤光片，被透镜收集至光电转化器，光电转化器将光信号转化为电信号，经信号放大器放大，再通过无线信号传输装置发送至外部 电子设备。
所述的无线信号传输装置选自WiFi芯片、蓝牙芯片、RIFD芯片或者其他的无线技术通信芯片。
所述的供电装置为微电池等。供电装置为传感器和无线信号传输装置供电，可共用一个供电装置或者分开使用。作为优选地，传感器和无线信号传输装置共用一个供电装置，节省空间，实现智能传感装置的小型化。
所述的电子设备为智能手机、电脑、平板等。
所述的富集装置位于卫生棉条的吸收体中。富集装置为上端开口，下端封闭的导管。开口位于卫生棉条插入端，开口下方有一可活动的挡板，当经血流入富集装置时，挡板在经血重力的作用下打开，无经血流入时，则该挡板处于封闭状态。富集装置的下端还有一富集装置抽线，用于富集装置的抽出。富集装置可富集女性月经血中的组织细胞、血液细胞、分泌物等。富集完成后，将富集装置拆分，通过第三方相关仪器及技术手段进一步分析确证女性经血中的生理生化指标，从而检测或确证疾病的发生。
本发明取得的有益效果：
1)本发明首次在卫生棉条中负载检测装置，实现了经血的即时检验。
2)集取样和诊断一体，不需患者出现在诊所，不会使患者感到羞辱，无损伤性和侵入性。
3)原位、实时诊断：本发明的卫生用品集样品采集、检测、数据加工处理于一体，只需在月经期间使用，即可通过电子设备接收检测数据。
4)可同时检测多种指标：a)可通过设置不同的传感器可实现不同生理生化指标的检测，如月经血量、pH、微生物等；b)对于含蛋白质传感器的经血检测装置而言，可通过调整基片上配体，实现不同的疾病诊断，如乙肝五项指标同时检测、肿瘤标志物检测、微量抗原抗体检测、SARS抗体药物鉴定、病毒检测及急性心急梗塞诊断标志物检测等。
5)多重检测保证准确性：本发明的卫生棉条还可设有可拆分的富集装置，可将经血中的细胞和体液等富集后，进一步通过第三方相关仪器及技术手段(如定量PCR及ELISA等)，分析确证各项生理生化指标，提高疾病预测和诊断的准确性。
附图说明
1.图1为本发明实施例一中的一种含试纸条的卫生棉条的示意图
2.图2为本发明实施例二中的一种含智能传感装置的卫生棉条的示意图
3.图3为本发明实施例二中的智能传感装置的示意图
4.图4为本发明实施例二中的蛋白质传感器的示意图
5.图5为本发明实施例三中的一种含富集装置的卫生棉条的示意图
6.图6为本发明实施例四中的一种含富集装置和智能传感装置的卫生棉条的示意图
7.图7为一种化学发光检测的原理的示意图
8.图8为一种荧光标记的检测原理的示意图
图示说明：
1.吸收体
11.卫生棉条插入端、12.卫生棉条抽出端
2.卫生棉条抽线
3.试纸条
31进样口、32.检测区、33.试纸条抽线
4.智能传感装置
41过滤装置、42.传感器、43.无线信号传输装置、44.供电装置
421.蛋白芯片、422.激发光光源、423.二向色滤光片、424.透镜、425光电转化器、426.信号放大器
5.富集装置
51开口、52挡板、53富集装置抽线
6.电子设备
具体实施方式
以下通过具体的实施例进一步说明本发明的技术方案，具体实施例不代表对本发明保护范围的限制。其他人根据本发明理念所做出的一些非本质的修改和调整仍属于本发明的保护范围。
实施例1 一种含有试纸条的卫生棉条
如图1所示的卫生棉条，含有吸收体1和卫生棉条抽线2，吸收体1内部设置有试纸条3(在本实例中，所述的试纸条3为HIV试纸条)。试纸条3顶部有一进样口31，进样口31位于卫生棉条的插入端11，试纸条3中间有一检测区32，检测区32可显示检测结果。整个试纸条3除进样口31和试纸条抽线33，试纸条3位于吸收体1中的结构处于密封状态，以防止吸收体1中的经血影响检测反应。试纸条3底部有一伸出试纸条抽线33，用于试纸条3的抽出。使用时，经血接触试纸条3的进样口，通过毛细作用，进入检测区33反应并显示结果。抽出卫生棉条后，再通过试纸条抽线33抽出试纸条3，即可观察检测结果。本发明含有试纸条的卫生棉条进行HIV的检测不受地点限制，无损伤性，便于及时发现疾病，具有重要的应用价值。除了HIV试纸条，本发明的卫生棉条也可负载其他现有技术中的试纸 条，或者是自己制作的试纸条。
实施例2 一种含智能传感装置的卫生棉条
如图2所示的卫生棉条，含有吸收体1和卫生棉条抽线2，吸收体1内部设置有智能传感装置4，所述的智能传感装置4通过无线信号与电子设备6连接。
如图3所示的智能传感装置4，上端设置有过滤装置41(在本实施例中为滤膜)，传感器42、无线信号传输装置43和供电装置44。所述的传感器42可以是现有技术中生物、物理和化学传感器中的一种或几种，例如，为现有技术中的酶传感器、免疫传感器、细菌传感器等中的一种或几种。所述的传感器42通过电路与无线信号传输装置43相连。无线信号传输装置43将电信号通过电磁波发射到电子设备6，电子设备6通过软件处理分析，得到经血中的生理生化指标。所述的电子设备6为手机、电脑、平板等(在本实施例中，所述的电子设备为手机，可在线实时查看身体健康状况)。所述的供电装置44通过电路与传感器42和无线信号传输装置43相连。所述的供电装置44为微电池。
更进一步地，本实施例的中的一个传感器为图4所示的蛋白质传感器。所述的蛋白质传感器含有蛋白芯片421、激发光光源422、、二向色滤光片423、透镜424、光电转化器425及信号放大器426。
所述的蛋白芯片421位于过滤装置41下方。蛋白芯片中固定有能与待测物质特异性反应的探针，经过滤装置41过滤的经血接触蛋白芯片421，待测的抗原等与蛋白芯片中带荧光标记的探针特异性结合，在激发光的照射下发出荧光。所述的待测物质如C12肿瘤标志物、HPV抗原等中的一种或几种。所述的蛋白芯片421为透明材质，激发光和荧光可以透过芯片底部。
二向色滤光片423位于蛋白芯片421下方，与激发光光源422处于同一水平水平面。激发光光源422发出激发光，二向色滤光片423反射激发光至蛋白芯片421，激发特异性结合的标记物质发出荧光，发出的荧光再透射过二向色滤光片。在本实施例中，所述的激发光光源为紫光LED。
所述的透镜444位于二向色滤光片423下方，将透过二向色滤光片423的荧光聚集到光电转化器425及信号放大器426。所述的光电转化器425和信号放大器426与无线信号传输装置43通过电路相连。经放大的电信号通过无线信号传输装置43发送到电子设备6，电子设备上配有相应的软件，通过软件对采集数据的处理分析，最终实现在线、实时了解测试者的健康状况。
本发明含智能传感装置的卫生棉条，通过对肿瘤标志物尤其是妇科肿瘤标志物、HPV抗原等检测，可以早期预警或辅助诊断、分析病程、指导治疗、监测复发或转移、判断预后等。
实施例3 一种含富集装置的卫生棉条
如图5所示的卫生棉条，含有吸收体1和卫生棉条抽线2，吸收体1内部设置有富集装置5，富集装置5下端封闭，上端有一开口51，富集装置5的开口51下方，设有一可活动挡板52，当经血流进入口51流入富集装置5时，挡板52在经血重力的作用下打开，无经血流入时，则该挡板52处于封闭状态。富集装置5的下端还有一富集装置抽线53，方便富集装置5的抽出。
富集装置5可富集女性月经血中的组织细胞、血液细胞、分泌物等。富集完成后，将富集装置5拆分，通过第三方相关仪器及技术手段进一步检测或确证女性经血中的生理生化指标，从而检测疾病的发生。
实施例4 一种含富集装置和智能传感装置的卫生棉条
如图6所示的卫生棉条内部设置有智能传感装置4和富集装置5.
智能传感装置重复实施例2，富集装置重复实施例3。

Claims (10)

  1. 一种卫生棉条，包含吸收体、卫生棉条抽线，其特征在于，所述的卫生棉条负载有检测装置和/或富集装置。
  2. 如权利要求1所述的卫生棉条，其特征在于，所述的检测装置为物理检测装置、化学检测装置、生物检测装置中的一种或几种；
    或者可选地，所述的检测装置为试纸条、智能传感装置中的一种或其组合。
  3. 如权利要求1所述的卫生棉条，其特征在于，所述的试纸条位于吸收体中，所述的试纸条顶端为进样口，进样口位于卫生棉条插入端；所述的试纸条底端含有一试纸条抽线，试纸条抽线位于卫生棉条抽出端；所述的试纸条还含有一检测区；
    优选地，所述的试纸为干式生化检测试纸条、血五项试纸、全血尿素生物传感试纸、微量元素测定试纸、HIV试纸中的一种或几种。
  4. 如权利要求1所述的卫生棉条，其特征在于，所述的智能传感装置位于卫生棉条吸收体中。
  5. 如权利要求4所述的卫生棉条，其特征在于，所述的智能传感装置含有传感器、无线信号传输装置和供电装置；
    优选地，所述的智能传感装置上方含有一过滤装置，过滤装置下方为传感器，传感器和无线信号传输装置通过电路相连。
  6. 如权利要求5所述的卫生棉条，其特征在于，所述的传感器为MEMS传感器；
    优选地，所述的传感器为物理传感器、化学传感器和生物传感器中的一种或几种；
    所述的物理传感器为湿度传感器、温度传感器、热敏传感器、重量传感器和体积传感器中的一种或几种；
    所述的化学传感器为离子敏传感器、气敏传感器、pH传感器；
    所述的生物传感器为微生物传感器、免疫传感器、组织传感器、细胞传感器、酶传感器、核酸传感器、蛋白质传感器中的一种或几种。
  7. 如权利要求5所述的卫生棉条，其特征在于，
    所述的过滤装置为过滤膜、过滤片、过滤网、过滤凝胶或过滤柱；优选地，为过滤膜；
    所述的无线信号传输装置为WiFi芯片、蓝牙芯片或RIFD芯片；
    所述的供电装置为微电池。
  8. 如权利要求6所述的卫生棉条，其特征在于，所述的传感器为蛋白质传感器，所述的蛋白质传感器含有蛋白芯片、激发光光源、二向色滤光片、透镜、光电转化器和信号放大器；
    所述的蛋白芯片位于过滤装置的下方；蛋白芯片为透明材质；所述的蛋白芯片、二向色 滤光片、透镜和光电转化器依次处于同一条直线；光电转化器与信号放大器通过电路相连。
  9. 如权利要求1所述的卫生棉条，其特征在于，所述的富集装置位于卫生棉条吸收体中；
    所述的富集装置上端有一开口，开口下方有一挡板；富集装置的下端有一富集装置抽线。
  10. 如权利要求1-9任意一项所述的卫生棉条为用于检测女性经血中的组织细胞/细菌/真菌/病毒/肿瘤标志物/HPV抗原/酶/微量元素/pH/激素/月经血量的检测棉条。
PCT/CN2016/103547 2016-10-27 2016-10-27 一种卫生棉条 WO2018076231A1 (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021167537A1 (en) 2020-02-18 2021-08-26 Plavec Dusan A storing device and a system for tracking absorption products

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1146143A (zh) * 1994-04-15 1997-03-26 阿瑟·L·西尔伯 防毒棉塞结构
WO2000072792A1 (en) * 1999-06-01 2000-12-07 Friedman, Mark, M. Improved drawstring for a catamenial device
US20040064114A1 (en) * 2002-09-27 2004-04-01 Benoit David Disposable articles having a failure detection system
CN1551749A (zh) * 2000-12-22 2004-12-01 ����ڶ�-PPC�ɷ����޹�˾ 女性卫生用阴道内置装置
CN101155568A (zh) * 2005-03-25 2008-04-02 奥特斯联合有限公司 棉塞涂抹器组件
US20100305530A1 (en) * 2007-02-09 2010-12-02 Larkin Kevin B Tampon Saturation Monitoring System

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1146143A (zh) * 1994-04-15 1997-03-26 阿瑟·L·西尔伯 防毒棉塞结构
WO2000072792A1 (en) * 1999-06-01 2000-12-07 Friedman, Mark, M. Improved drawstring for a catamenial device
CN1551749A (zh) * 2000-12-22 2004-12-01 ����ڶ�-PPC�ɷ����޹�˾ 女性卫生用阴道内置装置
US20040064114A1 (en) * 2002-09-27 2004-04-01 Benoit David Disposable articles having a failure detection system
CN101155568A (zh) * 2005-03-25 2008-04-02 奥特斯联合有限公司 棉塞涂抹器组件
US20100305530A1 (en) * 2007-02-09 2010-12-02 Larkin Kevin B Tampon Saturation Monitoring System

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021167537A1 (en) 2020-02-18 2021-08-26 Plavec Dusan A storing device and a system for tracking absorption products

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