WO2018050955A1 - Insulin pen - Google Patents

Insulin pen Download PDF

Info

Publication number
WO2018050955A1
WO2018050955A1 PCT/FI2017/000014 FI2017000014W WO2018050955A1 WO 2018050955 A1 WO2018050955 A1 WO 2018050955A1 FI 2017000014 W FI2017000014 W FI 2017000014W WO 2018050955 A1 WO2018050955 A1 WO 2018050955A1
Authority
WO
WIPO (PCT)
Prior art keywords
insulin
pen
insulin pen
reservoir
propellant gas
Prior art date
Application number
PCT/FI2017/000014
Other languages
French (fr)
Other versions
WO2018050955A8 (en
Inventor
Juha Hakala
Original Assignee
Oy Fiseca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oy Fiseca Ltd filed Critical Oy Fiseca Ltd
Publication of WO2018050955A1 publication Critical patent/WO2018050955A1/en
Publication of WO2018050955A8 publication Critical patent/WO2018050955A8/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2046Media being expelled from injector by gas generation, e.g. explosive charge
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053Media being expelled from injector by pressurised fluid or vacuum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/3148Means for causing or aiding aspiration or plunger retraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31545Setting modes for dosing
    • A61M5/31548Mechanically operated dose setting member
    • A61M5/3155Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2466Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
    • A61M2005/247Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase with fixed or steady piercing means, e.g. piercing under movement of ampoule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M2005/3125Details specific display means, e.g. to indicate dose setting
    • A61M2005/3126Specific display means related to dosing

Definitions

  • This invention relates to an insulin pen, comprising an insulin reservoir and an injection needle, and at the opposite end of the insulin pen a press-button, by means of which an insulin dose is injected in the patient's body.
  • a pharmaceutical was injected in the body of an individual by human power by means of a mechanically operating pen device, such as for instance NovoRapid, FlexPen, Lantus Solostar, and other models.
  • the purpose of the invention is to eliminate the disadvantages mentioned above.
  • the insulin pen in accordance with the invention is characterised by the fact that the insulin pen comprises a pressure reservoir filled with propellant gas, the pressure reservoir being opened by pressing a press-button so that the propellant gas presses the insulin dose through the injection needle into the patient's body.
  • the injection moment always lasts 10 seconds, during which the patient receives a maximally uniform insulin dose regardless of the number of units to be injected. This ensures a well balanced treatment of the patient.
  • the prefilled pressure cartridge of the insulin pen is emptied to 100%.
  • Prefilled insulin pens known per se such as e.g. NovoRapid, FlexPen and Lantus Solostar will contain a remainder of drug liquid of 10 units, even if the pen is in zero position. The cut in insulin will thus be considerable.
  • the pen is safe and easy to use.
  • the insulin pen emits distinct and audible clicks at regular intervals. At the moment of injection, the pen emits a weak sound over the entire injection duration for the user to internalise the injection time.
  • This economisation corresponds to one prefilled insulin pen.
  • On a global scale this is a remarkable gain.
  • the worldwide number of users exceeds 300 millions.
  • Anybody can conclude the amount of insulin and the number of insulin pens economised with the insulin pen in accordance with the invention.
  • Persons with a physical disability learn how to use the insulin pen exceptionally well. It is easy for a blind person to internalise the injection process.
  • the pen is safe for injections in persons suffering from other medical conditions and for the elderly. No physical force is required for carrying out the injection under the skin into the body.
  • a pressure-operated prefilled insulin pen can also be converted for use with a removable cartridge.
  • the pressure chamber can be converted into a pressure cylinder.
  • the insulin pen comprises an insulin reservoir 1 and an injection needle 2, and at the opposite end of the insulin pen, a press-button 3, by means of which an insulin dose is injected into the patient's body.
  • the insulin pen comprises a pressure reservoir 4 filled with propellant gas, and the pressure reservoir can be opened with the press- button 3 so that the propellant gas presses an insulin dose through the injection needle 2 into the patient's body.
  • a piston 6 pressed by propellant gas is provided between the pressure reservoir 4 and the insulin reservoir and moves within the body 5 of the insulin pen, thus pressing the total insulin dose into the patient's body.
  • a control knob 7 for the number of insulin units is located in connection with the press-button 3 for control of the insulin dosage.
  • a reading of the number of units to be controlled and the one desired is shown in the dose window 8.
  • a pressure nozzle 9 is provided between the pressure reservoir 4 and the piston 6 for choking the amount of propellant gas so as to set the specific injection duration, preferably 10 seconds.
  • the present embodiment comprises a cylindrical insulin reservoir within the body, which, however, can be replaced with a removable cartridge. If necessary, a refilling valve 10 may be provided in the upper part of the pressure reservoir 4 for cases when the user refills the pressure reservoir personally.
  • the injection needle 2 is supported with a rubber stopper 11 and protected with a pen casing 12.
  • the length L of the injection needle may be e.g. app. 140 mm and the diameter D app. 15 mm.
  • the dimensions of a potential cartridge used in the injection needle are; length 67 mm and diameter 11 mm.
  • a dosage control system operating with a plastic cogwheel known per se is located between the control knob and the pressure reservoir for controlling the dosage (not shown in the figure).

Abstract

The invention relates to an insulin pen comprising an insulin reservoir (1) and an injection needle (2), and at the opposite end of the insulin pen, a press-button (3), by means of which an insulin dose is injected into the patient's body. The insulin pen comprises a pressure reservoir (4) which is filled with propellant gas and can be opened by pressing the press-button so that the propellant gas presses an insulin dose through the injection needle (2) into the patient's body.

Description

Insulin pen
This invention relates to an insulin pen, comprising an insulin reservoir and an injection needle, and at the opposite end of the insulin pen a press-button, by means of which an insulin dose is injected in the patient's body.
Previously a pharmaceutical was injected in the body of an individual by human power by means of a mechanically operating pen device, such as for instance NovoRapid, FlexPen, Lantus Solostar, and other models.
Injections are difficult to carry out regarding patients with physical disabilities and elderly people. It has also been noted that the waste percentage of prefilled insulin pens is app. 10 units.
The purpose of the invention is to eliminate the disadvantages mentioned above. The insulin pen in accordance with the invention is characterised by the fact that the insulin pen comprises a pressure reservoir filled with propellant gas, the pressure reservoir being opened by pressing a press-button so that the propellant gas presses the insulin dose through the injection needle into the patient's body.
Various embodiments of the invention are described in the dependent claims of the set of claims.
The injection moment always lasts 10 seconds, during which the patient receives a maximally uniform insulin dose regardless of the number of units to be injected. This ensures a well balanced treatment of the patient. The prefilled pressure cartridge of the insulin pen is emptied to 100%. Prefilled insulin pens known per se, such as e.g. NovoRapid, FlexPen and Lantus Solostar will contain a remainder of drug liquid of 10 units, even if the pen is in zero position. The cut in insulin will thus be considerable. The pen is safe and easy to use. The insulin pen emits distinct and audible clicks at regular intervals. At the moment of injection, the pen emits a weak sound over the entire injection duration for the user to internalise the injection time.
Assuming a consumption of 30 prefilled insulin pens witch each of them leaving 10 units in the cartridge, the insulin pen in accordance with the invention achieves a reduction of 30x10=300 units, equalling 3 ml. This economisation corresponds to one prefilled insulin pen. On a global scale this is a remarkable gain. The worldwide number of users exceeds 300 millions. Anybody can conclude the amount of insulin and the number of insulin pens economised with the insulin pen in accordance with the invention. Persons with a physical disability learn how to use the insulin pen exceptionally well. It is easy for a blind person to internalise the injection process. The pen is safe for injections in persons suffering from other medical conditions and for the elderly. No physical force is required for carrying out the injection under the skin into the body. A pressure-operated prefilled insulin pen can also be converted for use with a removable cartridge. The pressure chamber can be converted into a pressure cylinder. Although this invention relates to an insulin pen, the pen in accordance with the invention is evidently appropriate for other pharmaceuticals to be injected as well. The invention is explained below by means of an example and with reference to the accompanying drawing, which illustrates the insulin pen in partial section.
The insulin pen comprises an insulin reservoir 1 and an injection needle 2, and at the opposite end of the insulin pen, a press-button 3, by means of which an insulin dose is injected into the patient's body. The insulin pen comprises a pressure reservoir 4 filled with propellant gas, and the pressure reservoir can be opened with the press- button 3 so that the propellant gas presses an insulin dose through the injection needle 2 into the patient's body. A piston 6 pressed by propellant gas is provided between the pressure reservoir 4 and the insulin reservoir and moves within the body 5 of the insulin pen, thus pressing the total insulin dose into the patient's body.
If a smaller dose than the entire dose provided in the pen is desired, a control knob 7 for the number of insulin units is located in connection with the press-button 3 for control of the insulin dosage. A reading of the number of units to be controlled and the one desired is shown in the dose window 8. A pressure nozzle 9 is provided between the pressure reservoir 4 and the piston 6 for choking the amount of propellant gas so as to set the specific injection duration, preferably 10 seconds. The present embodiment comprises a cylindrical insulin reservoir within the body, which, however, can be replaced with a removable cartridge. If necessary, a refilling valve 10 may be provided in the upper part of the pressure reservoir 4 for cases when the user refills the pressure reservoir personally. The injection needle 2 is supported with a rubber stopper 11 and protected with a pen casing 12. The length L of the injection needle may be e.g. app. 140 mm and the diameter D app. 15 mm. The dimensions of a potential cartridge used in the injection needle are; length 67 mm and diameter 11 mm. A dosage control system operating with a plastic cogwheel known per se is located between the control knob and the pressure reservoir for controlling the dosage (not shown in the figure).

Claims

Claims
1. an insulin pen comprising an insulin reservoir (1) and an injection needle (2), and at the opposite end of the insulin pen, a press-button (3), by means of which an insulin dose is injected into the patient's body, characterised in that the insulin pen comprises a pressure reservoir (4) which is filled with propellant gas and can be opened by pressing the press-button so that the propellant gas presses the insulin dose through the injection needle (2) into the patient's body.
2. An insulin pen as defined in claim 1 , characterised in that a piston (6) pressed by propellant gas and moving within the body (5) of the insulin pen is provided between the pressure reservoir (4) and the insulin reservoir (1), the piston pressing the entire insulin dose into the patient's body. .
3. An insulin pen as defined in claim 1 or 2, characterised in that a control knob (7) of the number of insulin units is provided in connection with the press-button (3) for controlling the insulin dosage.
4. An insulin pen as defined in claim 1 , 2 or 3, characterised in that a pressure nozzle (9) is provided between the pressure reservoir (4) and the piston (6) for choking the amount of propellant gas so as to set the specific injection duration, preferably 10 seconds.
PCT/FI2017/000014 2016-09-13 2017-09-12 Insulin pen WO2018050955A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20160228 2016-09-13
FI20160228 2016-09-13

Publications (2)

Publication Number Publication Date
WO2018050955A1 true WO2018050955A1 (en) 2018-03-22
WO2018050955A8 WO2018050955A8 (en) 2018-10-04

Family

ID=61619065

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI2017/000014 WO2018050955A1 (en) 2016-09-13 2017-09-12 Insulin pen

Country Status (1)

Country Link
WO (1) WO2018050955A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020012178A1 (en) * 2018-07-10 2020-01-16 Pacifi Limited Method and apparatus

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3977401A (en) * 1975-03-25 1976-08-31 William Floyd Pike Injection apparatus
US6045534A (en) * 1997-10-27 2000-04-04 Sarcos, Inc. Disposable fluid injection module
US20110092906A1 (en) * 2008-06-19 2011-04-21 Arzeneimittel Gmbh Apotheker Vetter & Co. Ravensburg Device with at least one chamber for receiving a medicament or a sample volume

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3977401A (en) * 1975-03-25 1976-08-31 William Floyd Pike Injection apparatus
US6045534A (en) * 1997-10-27 2000-04-04 Sarcos, Inc. Disposable fluid injection module
US20110092906A1 (en) * 2008-06-19 2011-04-21 Arzeneimittel Gmbh Apotheker Vetter & Co. Ravensburg Device with at least one chamber for receiving a medicament or a sample volume

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020012178A1 (en) * 2018-07-10 2020-01-16 Pacifi Limited Method and apparatus

Also Published As

Publication number Publication date
WO2018050955A8 (en) 2018-10-04

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