WO2018032838A1 - 一种平衡男性5α-还原酶的中药酵素 - Google Patents

一种平衡男性5α-还原酶的中药酵素 Download PDF

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WO2018032838A1
WO2018032838A1 PCT/CN2017/085031 CN2017085031W WO2018032838A1 WO 2018032838 A1 WO2018032838 A1 WO 2018032838A1 CN 2017085031 W CN2017085031 W CN 2017085031W WO 2018032838 A1 WO2018032838 A1 WO 2018032838A1
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traditional chinese
chinese medicine
enzyme
reductase
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谭华锋
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谭华锋
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Definitions

  • the invention relates to a hair loss prevention and treatment agent, in particular to a biological enzyme prevention and treatment hair loss agent.
  • Sebrrheic alopecia also known as male pattern alopecia (MPA), and androgenetic alopecia (AGA), occurs mostly in young and middle-aged men, 25 to 40 years old. About one-third of adult males develop varying degrees of hair loss. Although the patient has no obvious symptoms, it is urgently required to treat because of the aesthetic appearance.
  • DHT dihydrotestosterone
  • 5 ⁇ -R 5 ⁇ -reductase
  • DHT is the main cause of hair loss. It binds to receptor proteins in cells, transfers to the nucleus, activates specific genes, induces the formation of specific proteins, thereby hindering the growth of hair, and thus producing permanent hair loss.
  • Men's hair loss is whitening, which is caused by excessive secretion of DHT, which causes the skin to secrete a lot of oil.
  • the oil contains a substance called 5 ⁇ -reductase, which will phagocytose and block hair follicles, causing hair loss.
  • DHT plays an important role in SA, and inhibits DHT synthesis by inhibiting 5 ⁇ -reductase activity, thereby achieving the purpose of preventing hair loss.
  • the inhibition of 5 ⁇ -reductase activity mainly uses western medicines such as finasteride, eprilate, ericylamine, and dutasteride, but the western medicine ingredients are highly irritating and have side effects, such as the side effects of finasteride.
  • the invention regulates the function of the spleen, stomach, liver and kidney and balances the androgen secretion of the human body through the traditional Chinese medicine and the enzyme, so that the 5 ⁇ -reductase is balanced, and the problem of seborrheic alopecia is basically solved.
  • the present invention adopts the following technical scheme: adding a microbial enzyme to a Chinese herbal extract in a ratio of 2:8 to prepare a traditional Chinese medicine enzyme;
  • the microbial enzyme is fermented by the following materials in a weight ratio:
  • Fermentation method firstly pour brown sugar into water and stir and melt, then immerse the sorghum, evergreen, tea seed, rice vinegar, Hericium erinaceus, seaweed in the sugar water for more than half a year, then put down the pine juice for two months of fermentation.
  • the fermentation temperature is 32 ⁇ 38 ° C, pH value of 6.0, during which attention to ventilation and ventilation, to avoid sunlight;
  • the traditional Chinese medicine extract is prepared by mixing water extracts of the following materials in proportion by weight:
  • the biological enzyme enzyme is an essential component of the human body's metabolic process, and more than 5,000 kinds of biological enzymes in the human body participate in metabolism to maintain a healthy body.
  • the human body is affected. Intake of specific nutrients, help the body to take nutrients from traditional Chinese medicines and foods, regulate spleen, stomach, liver and kidney function, balance the body's androgen secretion, so that 5 ⁇ -reductase is balanced, basically solving the problem of seborrheic alopecia problem.
  • a traditional Chinese medicine enzyme for balancing male 5 ⁇ -reductase includes: adding a microbial enzyme to a Chinese herbal extract in a ratio of 2:8 to prepare a traditional Chinese medicine enzyme;
  • the microbial enzyme is fermented by the following materials in a weight ratio:
  • Fermentation method firstly pour brown sugar into water and stir and melt, then immerse the sorghum, evergreen, tea seed, rice vinegar, Hericium erinaceus, seaweed in the sugar water for more than half a year, then put down the pine juice for two months of fermentation.
  • the fermentation temperature is 37 ° C
  • the pH value is 6.0, during which attention is paid to ventilation and ventilation, and sunlight is avoided;
  • the traditional Chinese medicine extract is prepared by mixing water extracts of the following materials in proportion by weight:
  • Bio-enzymes are essential for the body's metabolic process. More than 5,000 enzymes in the human body are involved in metabolism to maintain a healthy body. When a certain part of the enzyme is insufficient or too much, it will affect the body's intake of specific nutrients. Through enzymes to help the body to take up the nutrients of traditional Chinese medicine and food, regulate the function of the liver, kidney and kidney of the spleen and stomach, balance the androgen secretion of the human body, so that the 5 ⁇ -reductase is balanced, basically solving the problem of seborrheic alopecia.

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Abstract

一种脱发防治剂，尤其涉及生物酶防治脱发剂，其特征在于：将微生物酶酵素按２：８的比例加入中药提取物之中混合制成中药酵素；微生物酶酵素由水、红糖、茯苓、万年青、茶籽、米醋、猴头菇、海藻、松树汁液发酵而成，中药提取物由莲子、生姜、山楂、麦芽、赤芍、牛膝、泽兰、益母草、紫草、当归的水提取物按重量比例混合而成。通过中药和酵素调节脾胃肝肾功能和平衡人体的雄激素分泌，从而５α-还原酶得到平衡，从基本上解决脂溢性脱发的问题。

Description

一种平衡男性5α-还原酶的中药酵素
本申请要求2016年08月13日提交的中国专利申请2016106650498号的优先权利益，在此通过引用将该优先权文件的全部内容合并至本文中。
技术领域
本发明涉及一种脱发防治剂，尤其涉及生物酶防治脱发剂。
背景技术
脂溢性脱发(sebrrheic alopecia,S A)，又名男性型秃发(male patternalopecia，MPA)，雄激素源性秃发(Androgenetic alopecia，AGA)，多发生于中、青年男性，25～40岁成年男性中约有1/3发生不同程度的脱发。尽管患者无明显自觉症状，但因影美观而迫切要求治疗。
头部毛发严格地受雄性激素的影响，男性体内主要的雄激素为睾酮，可以在5α-还原酶(5α-R)的作用下代谢成为双氢睾酮(Dihydrotestosterone，DHT)。而DHT是引起脱发的主要原因，它能与细胞内的受体蛋白质结合，转移到细胞核内，将特定的基因活化，诱导生成特定的蛋白质，从而阻碍了毛发的生长，进而产生永久性的脱发或秃发。男人脱发说白了就是DHT分泌过度，导致皮肤大量分泌油脂，油脂中含有一种叫5α-还原酶的物质，这种物质会吞噬，阻塞毛囊，导致毛发脱落。DHT在SA中起着重要的作用，通过抑制5α-还原酶活性即可抑制DHT合成，从而达到防脱发的目的。目前对5α-还原酶活性的抑制主要采用非那雄胺、爱普列特、依立雄胺、度他雄胺等西药成分，但西药成分刺激性大、副作用大，如非那雄胺副作用的会导致男性性欲减退、阳痿、射精量减少的症状；爱普列特副 作用导致恶心、失眠、头昏、勃起功能障碍的症状，在这里不一一列举。
我国关于酵素中的微生物种类和数量的文章还很少，酵素产品的生产工艺大多是日本专利，因此在国内售价很高，因此需要积极开发有自主知识产权的工艺技术，以降低生产成本。
发明内容
本发明通过中药和酵素调节脾胃肝肾功能和平衡人体的雄激素分泌，从而5α-还原酶得到平衡，从基本上解决脂溢性脱发的问题。
为实现上述目的，本发明采用以下技术方案：将微生物酶酵素按2:8的比例加入中药提取物之中混合制成中药酵素；
所述的微生物酶酵素采用以下材料按重量比例发酵而成：
水50～71份、红糖7～11份、茯苓8～12份、万年青5～6份、茶籽13～15份、米醋5～9份、猴头菇7～9份、海藻2～6份、松树汁液3～5份；
发酵的方法：先将红糖倒入水中搅拌融化，再将茯苓、万年青、茶籽、米醋、猴头菇、海藻浸于糖水之中发酵素半年以上，然后再放下松树汁液二次发酵两个月以上，发酵的温度32～38℃、pH值6.0，期间注意通风透气、避免阳光；
所述的中药提取物采用以下材料的水提取物按重量比例混合而成：
莲子5～8份、生姜8～12份、山楂7～13份、麦芽3～6份、 赤芍6～9份、牛膝9～15份、泽兰1～2份、益母草4～8份、紫草3～8份、当归8～18份。
本发明的有益效果：生物酶酵素是人体新陈代谢过程的必须物，人体之中有5000多种生物酶酵素参与代谢才能维持健康的身体，当某部分生物酶酵素不足或过多时，就会影响人体对特定的营养成份摄取，通过酵素帮助人体对中药和食物的营养成份摄取，调节脾胃肝肾功能，平衡人体的雄激素分泌，从而5α-还原酶得到平衡，从基本上解决脂溢性脱发的问题。
具体实施方式
一种平衡男性5α-还原酶的中药酵素包括有：将微生物酶酵素按2:8的比例加入中药提取物之中混合制成中药酵素；
所述的微生物酶酵素采用以下材料按重量比例发酵而成：
水63份、红糖9份、茯苓9份、万年青5份、茶籽14份、米醋7份、猴头菇8份、海藻5份、松树汁液4份；
发酵的方法：先将红糖倒入水中搅拌融化，再将茯苓、万年青、茶籽、米醋、猴头菇、海藻浸于糖水之中发酵素半年以上，然后再放下松树汁液二次发酵两个月以上，发酵的温度37℃、pH值6.0，期间注意通风透气、避免阳光；
所述的中药提取物采用以下材料的水提取物按重量比例混合而成：
莲子6份、生姜9份、山楂9份、麦芽4份、赤芍8份、牛膝11份、泽兰2份、益母草6份、紫草5份、当归12份。
生物酶酵素是人体新陈代谢过程的必须物，人体之中有5000多种生物酶酵素参与代谢才能维持健康的身体，当某部分生物酶酵素不足或过多时，就会影响人体对特定的营养成份摄取，通过酵素帮助人体对中药和食物的营养成份摄取，调节脾胃肝肾功能，平衡人体的雄激素分泌，从而5α-还原酶得到平衡，从基本上解决脂溢性脱发的问题。
最后应说明的是：显然，上述实施例仅是为清楚地说明本发明所作的举例，而并非对实施方式的限定。对于所属领域的普通技术人员来说，在上述说明的基础上还可以做出其它不同形式的变化或变动。这里无需也无法对所有的实施方式予以穷举。而由此所引申出的显而易见的变化或变动仍处于本发明的保护范围之中。

Claims (1)

  1. 一种平衡男性5α-还原酶的中药酵素，其特征在：将微生物酶酵素按2:8的比例加入中药提取物之中混合制成中药酵素；
    所述的微生物酶酵素采用以下材料按重量比例发酵而成：
    水50～71份、红糖7～11份、茯苓8～12份、万年青5～6份、茶籽13～15份、米醋5～9份、猴头菇7～9份、海藻2～6份、松树汁液3～5份；
    发酵的方法：先将红糖倒入水中搅拌融化，再将茯苓、万年青、茶籽、米醋、猴头菇、海藻浸于糖水之中发酵素半年以上，然后再放下松树汁液二次发酵两个月以上，发酵的温度32～38℃、pH值6.0，期间注意通风透气、避免阳光；
    所述的中药提取物采用以下材料的水提取物按重量比例混合而成：
    莲子5～8份、生姜8～12份、山楂7～13份、麦芽3～6份、赤芍6～9份、牛膝9～15份、泽兰1～2份、益母草4～8份、紫草3～8份、当归8～18份。
PCT/CN2017/085031 2016-08-13 2017-05-19 一种平衡男性5α-还原酶的中药酵素 WO2018032838A1 (zh)

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CN106110037A (zh) * 2016-08-13 2016-11-16 黄剑忠 一种平衡男性5α‑还原酶的中药酵素
CN106266448A (zh) * 2016-08-13 2017-01-04 黄剑忠 一种生物酵素防治脱发剂
CN108186443A (zh) * 2018-02-23 2018-06-22 广州市骄子日化有限公司 一种白发转黑的洗发液及其制备方法
CN110693016A (zh) * 2019-11-08 2020-01-17 易大发 一种茶籽壳酵素及其制备方法

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