WO2017217660A1 - Composition contenant de l'acide subérique ou un sel de celui-ci utilisé comme principe actif, et ayant comme effets d'améliorer l'hydratation de la peau, l'exfoliation de la peau, d'améliorer l'élasticité de la peau, d'inhiber un érythème, d'atténuer les rides de la peau, ou d'atténuer le photovieillissement de la peau - Google Patents

Composition contenant de l'acide subérique ou un sel de celui-ci utilisé comme principe actif, et ayant comme effets d'améliorer l'hydratation de la peau, l'exfoliation de la peau, d'améliorer l'élasticité de la peau, d'inhiber un érythème, d'atténuer les rides de la peau, ou d'atténuer le photovieillissement de la peau Download PDF

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WO2017217660A1
WO2017217660A1 PCT/KR2017/004999 KR2017004999W WO2017217660A1 WO 2017217660 A1 WO2017217660 A1 WO 2017217660A1 KR 2017004999 W KR2017004999 W KR 2017004999W WO 2017217660 A1 WO2017217660 A1 WO 2017217660A1
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Prior art keywords
skin
composition
acid
improving
elasticity
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PCT/KR2017/004999
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English (en)
Korean (ko)
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박태선
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연세대학교 산학협력단
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Priority claimed from KR1020160073324A external-priority patent/KR101742219B1/ko
Priority claimed from KR1020170049615A external-priority patent/KR101754556B1/ko
Application filed by 연세대학교 산학협력단 filed Critical 연세대학교 산학협력단
Publication of WO2017217660A1 publication Critical patent/WO2017217660A1/fr

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention relates to a composition containing suveric acid or a salt thereof as an active ingredient, and more particularly, to enhance skin moisture content, reduce skin moisture evaporation amount, increase procollagen secretion amount, promote collagen biosynthesis, inhibit collagen fiber damage, collagen fiber It has the effect of improving skin moisturizing, removing skin dead skin, enhancing skin elasticity, suppressing erythema, improving skin wrinkles and / or improving skin photoaging by using suveric acid or a salt thereof that inhibits degradation, inhibits erythema and thickens the skin epidermal layer. It relates to a cosmetic composition, nutraceutical composition, quasi-drug composition, quasi-drug composition and use thereof.
  • the skin is composed of three layers: epidermis, dermis, and hypodermis.
  • stratum corneum the outermost layer of the epidermis, acts as a skin barrier, inhibiting the loss of water and electrolytes from the skin, while the dermal layer plays a role in maintaining the elasticity of the skin and supporting the structure through collagen and elastin synthesis.
  • collagen and elastin are major proteins produced in fibroblasts and are closely related to skin mechanical firmness, tissue cohesion and elasticity (Moskowit, RW et al, Role of collagen hydroiysate in bone and joint disease, Semin Arthritis Rheu, 30 : 87, 2000).
  • Collagen forms various isoforms according to its shape and structural features.
  • collagen isotypes There are 28 kinds of collagen isotypes in human tissues.
  • collagen types collagen type 1, 3. 4 6. 7. 13, 14, 17, etc. are known.
  • Collagen types 1 and 3 make up the interstitial components of the dermal layer
  • collagen type 7 is a major component of the dermal and epidermal junctions (Pei, M. et al., Expression of collagen). type I, II and III in loose body of osteoarthitis, J. Orthop. Sci., 5: 288, 2000).
  • Type I collagen is the largest amount of extracellular matrix protein in the skin connective tissue, and there are other proteins such as elastin, fibronectin, integrin, fibrillin, and proteoglycan.
  • the newly synthesized procollagen is secreted into the extracellular space of skin cells through an enzymatic reaction to form a microfibril of triple helix configuration, and the microfibrils are leucine-rich small proteoglycans (leucine). It combines with rich small proteoglycans to form fibrils. As a result, the fibrils thus produced form collagen fibers that provide skin binding and elasticity (Bateman, J.F. et al., Collagen superfamily.Extracellular matrix, Harwood, New York, 2, 22-26, 1996).
  • Skin aging is known to be due to a decrease in the content of collagen, a protein that accounts for most of the collagen of skin dermis. Collagen decreases the relationship between skin aging and wrinkle formation because collagen imparts tension and strength to the skin. have.
  • Skin aging is largely divided into endogenous aging due to physiological aging and photoaging caused by continuous ultraviolet radiation (UV) exposure. Repeated ultraviolet exposure results in increased collagen degrading enzymes and causing denaturation and destruction of collagen fibers, reducing the elasticity of the skin and promoting the production of wrinkles.
  • UV continuous ultraviolet radiation
  • ROS reactive oxygen species
  • Activation of these receptors results in continuous phosphorylation that activates downstream signaling mediators, including mitogen-activated protein kinase (MAPK), resulting in activator protein-1 And activating transcription factors such as NF- ⁇ B (nuclear factor ⁇ B) to induce an inflammatory response and to promote the activity of collagenase, such as matrix metalloproteinase (MMPs), to reduce skin elasticity and promote wrinkle formation (Kang, S. et al., Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-kB and activator protein-l in Inflammatory acne lesions in vivo.Am J. Pathol., 166: 1691-1699, 2005) .
  • MMPs matrix metalloproteinase
  • MMP-1 regulates the expression of numerous genes involved in cell growth and differentiation and strongly regulates the expression of some MMPs.
  • MMP-1 is known as collagenase 1, and is based on type 1 and 3 collagen.
  • suveric acid is detected as a metabolite in urine and used as an indicator of ketosis (Pettersen et al, The occurrence of adipic and suberic acid in urine from ketotic patients.Clin Chim Acta 38 (17-24,1972), which has also been reported to detect high concentrations in urine in diabetic patients (Yoshioka et al, Measurements of urinary adipic acid and suberic acid using high-performance liquid chromatography.J Chromatogr B Biomed Appl. 655: 189-93, 1994).
  • Pettersen et al The occurrence of adipic and suberic acid in urine from ketotic patients.Clin Chim Acta 38 (17-24,1972), which has also been reported to detect high concentrations in urine in diabetic patients (Yoshioka et al, Measurements of urinary adipic acid and suberic acid using high-performance liquid chromatography.J Chromatogr B Biomed Appl. 655: 189-93,
  • the present inventors conducted research to develop a food or cosmetic material that is effective in improving wrinkles by inhibiting the action of collagen degrading enzymes in natural products with fewer side effects and promoting collagen synthesis.
  • the present invention was completed by confirming that the moisturizing improvement, skin exfoliation, skin elasticity enhancement, erythema suppression, skin wrinkle improvement and / or skin photoaging improvement effect.
  • An object of the present invention is to provide a cosmetic composition having an effect of improving skin moisturizing, skin exfoliation, skin elasticity enhancement, erythema suppression, skin wrinkle improvement and / or skin photoaging.
  • Another object of the present invention is to provide a health functional food composition having an effect of improving skin moisturizing, removing skin dead skin, enhancing skin elasticity, suppressing erythema, improving skin wrinkles and / or improving skin photoaging.
  • Another object of the present invention is to provide a quasi-drug composition and pharmaceutical composition having the effect of improving skin moisturizing, skin exfoliation, skin elasticity enhancement, erythema suppression, skin wrinkle improvement and / or skin photoaging improvement.
  • Another object of the present invention is to improve skin moisturization, skin exfoliation, skin elasticity, erythema suppression, wrinkle improvement or skin photoaging improvement using a composition containing suberic acid or a salt thereof as an active ingredient.
  • the present invention is to improve the skin moisturizing, skin exfoliation, skin elasticity, erythema suppression, wrinkle improvement and / or skin containing suveric acid or its cosmetically acceptable salt as an active ingredient
  • a cosmetic composition having a photoaging improvement effect.
  • the present invention also provides a skin moisturizing improvement, skin exfoliation, skin elasticity improvement, erythema suppression, wrinkle improvement and / or skin photoaging improvement effect, which contain suveric acid or a food acceptable salt thereof as an active ingredient.
  • a nutraceutical composition which contain suveric acid or a food acceptable salt thereof as an active ingredient.
  • the subic acid or its cosmetically acceptable salt may be included in 0.0001 to 20% by weight based on the total weight of the cosmetic composition.
  • the cosmetic composition is a skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisturizing lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, essence Any one selected from the group consisting of: pack, mask pack, mask sheet, exfoliant, soap, shampoo, cleansing foam, cleansing lotion, cleansing cream, body lotion, body cleanser, latex, press powder, loose powder and eye shadow It can be prepared as.
  • the health functional food composition may be prepared in any one formulation selected from the group consisting of tablets, granules, powders, capsules, liquid solutions and rings.
  • the cosmetic composition or health functional food composition may further comprise a skin wrinkle improvement component.
  • the additional skin wrinkle improvement component is selected from the group consisting of vitamin C, retinoic acid, transforming growth factor (TGF), protein from animal placenta, betulinic acid and chlorella extract It may be any one or more.
  • TGF transforming growth factor
  • the present invention also provides quasi-drugs and pharmaceutical compositions having the effect of improving skin moisturizing, removing skin dead skin, enhancing skin elasticity, inhibiting erythema, improving skin wrinkles and / or improving skin photoaging, including suveric acid or a salt thereof as an active ingredient. to provide.
  • the present invention also provides a method for improving skin moisturizing, removing skin exfoliation, enhancing skin elasticity, suppressing erythema, improving skin wrinkles or improving skin photoaging using a composition containing the subic acid or a salt thereof as an active ingredient.
  • compositions containing suveric acid or a salt thereof of the present invention as an active ingredient may improve skin moisture content, reduce skin moisture evaporation amount, increase procollagen secretion, promote collagen biosynthesis, inhibit collagen fiber damage, inhibit collagen fiber degradation, inhibit erythema and skin
  • the epidermal layer has an excellent thickening inhibitory activity and can be usefully used for improving skin moisturizing, removing skin exfoliation, enhancing skin elasticity, inhibiting erythema, improving skin wrinkles and / or improving skin photoaging.
  • the sub acid of the present invention is a natural product, it is safe for the human body and has less side effects, and thus may be used in various materials such as cosmetics, health foods, medicines or quasi-drugs.
  • 1 is a graph showing the results of measuring procollagen secretion by ELISA analysis after irradiating UVB at 20 mJ / cm 2 to human skin fibroblasts for 24 hours with 100 ⁇ M of vitamin C or suveric acid (- UVB: Normal group not treated with UVB, + UVB: Control group treated with UVB, SA: Experiment group treated with suveric acid after irradiation with UVB, VitC: Control group treated with vitamin C after irradiation with UVB, SA + VitC: Irradiated with UVB and treated with subvertic acid and vitamin C).
  • Figure 2 is a graph showing the weight gain and dietary intake of mice fed the experimental diet having the composition of Table 1 (A: weight, B: weight gain, C and D: diet intake).
  • Figure 3 is a graph showing the water content (A), water evaporation (B), elasticity (C) and erythema index (D) of the skin tissue of mice fed the experimental diet having the composition of Table 1.
  • Figure 4 is a photograph showing the back skin tissue of each mouse fed the experimental diet having the composition of Table 1.
  • FIG. 5 is a photograph (A) and a graph (B) showing the degree of wrinkle formation of the back skin tissue of the mouse fed the experimental diet having the composition of Table 1.
  • FIG. 6 is a graph (A) and skin epidermal layer photograph (B) of measuring skin thickness of mice fed an experimental diet having the composition of Table 1.
  • FIG. 6 is a graph (A) and skin epidermal layer photograph (B) of measuring skin thickness of mice fed an experimental diet having the composition of Table 1.
  • Figure 7 is a photograph observing the change in the amount and morphology of collagen fibers in mice fed an experimental diet having the composition of Table 1.
  • Figure 8 shows the results of measuring the change in the expression of collagen and MMP genes in the hairless mouse back tissue treated with suberic acid by RT-PCR.
  • subvertic acid is reported to be used as an indicator of ketosis patients or to be detected at high concentrations in the urine of diabetic patients, but there is no bioactive function specifically reported for subvertic acid.
  • the present inventors have identified a novel activity of suveric acid related to skin health, and developed a cosmetic composition, a nutraceutical composition, and a quasi-drug composition containing suveric acid or a salt thereof as an active ingredient.
  • the composition provided by the present invention has excellent skin hydration content, reduced skin moisture evaporation amount, increased procollagen secretion, increased collagen biosynthesis, inhibited collagen fiber damage, inhibited collagen fiber degradation, erythema suppression and thickening inhibitory effect of skin epidermal layer. It can be usefully used for improvement, skin moisturization improvement, skin exfoliation, skin elasticity improvement, erythema suppression, skin wrinkle improvement and / or skin photoaging improvement.
  • the present invention is a cosmetic having the effect of improving skin moisturizing, skin exfoliation, skin elasticity, erythema suppression, skin wrinkles and / or skin photoaging improvement effect containing suveric acid or a cosmetically acceptable salt thereof as an active ingredient To provide a composition.
  • Subic acid is a kind of dibasic acid represented by the following Chemical Formula 1, a needle-shaped crystal, Cas No. is 505-48-6, the structural formula is C 8 H 14 O 4 , and the molecular weight is 174.2 g / mol.
  • Suberic acid is also known as tinnitus such as octanedioic acid, cork acid and 1,6-hexanedicarboxylic acid.
  • the melting point of suveric acid is 141-144 ° C and the boiling point is 230 ° C.
  • Subic acid Ricinus communis L. (Castor oil plant, Castor), Quercus suber (Cork tree, Cork), Vernonia It is mainly found in plants such as galamensis (Ironweed, thistle flower).
  • the method for obtaining suveric acid of the present invention is not particularly limited, and may be isolated from plants containing suveric acid, chemically synthesized using a known manufacturing method, or commercially available.
  • the LD 50 value of suberic acid has been reported to be greater than 2000 mg / kg upon oral administration to rats (Company Info., Contact Reagent World, Material Safety Data Sheet, [Legal Information]).
  • oral administration of suveric acid at 0.1 mg / kg to 1,500 mg / kg, preferably 10 mg / kg to 1,000 mg / kg is not very toxic or cosmetic compositions, dietary supplements or quasi-drug compositions. Or the like.
  • the suveric acid may include a suveric acid hydrate, a suveric acid derivative, and the like within a range having the same efficacy, and may include a solvate or stereoisomer thereof.
  • the term "improve skin wrinkles” means maintaining or enhancing the ability to be associated with wrinkles and elasticity of the skin.
  • Collagen (collagen) and elastic fiber elastin (collagen) in the dermal layer of the skin is the main protein that plays a role in the skin elasticity, collagen biosynthesis is affected by the internal and external skin.
  • the skin cells are reduced in cell activity due to natural aging, the collagen fibers are reduced, or the active oxygen produced by excessive irradiation of ultraviolet rays or stress as an external factor, the thiol group of the protein (thiol: -SH)
  • the enzyme activity or by increasing the expression of degradation enzymes, such as collagen, elastin, increase the wrinkles of the skin and decrease the elasticity, the skin aging progresses.
  • the terms "cosmetic acceptable salt”, “food acceptable salt”, “pharmaceutically acceptable salt” or “salt thereof” may be an acid addition salt formed by free acid.
  • Acid addition salts can be prepared by conventional methods, for example by dissolving a compound in an excess of aqueous acid solution and precipitating the salt using a water miscible organic solvent such as methanol, ethanol, acetone or acetonitrile.
  • a water miscible organic solvent such as methanol, ethanol, acetone or acetonitrile.
  • equimolar amounts of the compound and acid or alcohol (eg, glycol monomethyl ether) in water can be heated and the mixture can then be evaporated to dryness or the precipitated salts can be suction filtered.
  • an inorganic acid or an organic acid may be used as the free acid.
  • the inorganic acid may be hydrochloric acid, phosphoric acid, sulfuric acid, nitric acid, tartaric acid, and the like, which may be used alone or in combination of two or more.
  • Non-limiting examples of the organic acid are methanesulfonic acid, p-toluenesulfonic acid, acetic acid, trifluoroacetic acid, maleic acid, succinic acid, oxalic acid, benzoic acid, tartaric acid, fumaric acid, manderic acid, propionic acid (propionic acid).
  • acid citric acid, lactic acid, glycolic acid, gluconic acid, galacturonic acid, glutamic acid, glutaric acid, glucuronic acid (glucuronic acid), aspartic acid, ascorbic acid, carbonic acid, vanic acid, hydroiodic acid and the like can be used. These may be used alone or in combination of two or more thereof.
  • the sub acid can be used to make a cosmetically or food acceptable metal salt using a base.
  • Alkali metal or alkaline earth metal salts can be obtained, for example, by dissolving the compound in an excess alkali metal hydroxide or alkaline earth metal hydroxide solution, filtering the insoluble compounds salt, and then evaporating and drying the filtrate.
  • the metal salt it is particularly preferable to prepare sodium, potassium or calcium salts, but is not limited thereto.
  • Corresponding silver salts can also be obtained by reacting an alkali or alkaline earth metal salt with a suitable silver salt (eg silver nitrate).
  • the salts of suberic acid may include all salts of acidic or basic groups which may be present in the compound of subric acid unless otherwise indicated.
  • the salt of suveric acid may include sodium, calcium and potassium salts of the hydroxyl group
  • other cosmetically acceptable salts of the amino group include hardbromide, sulfate, hydrogen sulfate, phosphate, hydrogen Phosphate, dihydrogen phosphate, acetate, succinate, citrate, tartrate, lactate, mandelate, methanesulfonate (mesylate) and p-toluenesulfonate (tosylate) salts and the like and are known in the art. It may be prepared through a method for preparing a salt.
  • the effective amount of subic acid or its cosmetically acceptable salt in the cosmetic composition of the present invention is not particularly limited and may be included in 0.0001 to 20% by weight based on the total weight of the composition. Less than 0.0001% by weight of suveric acid or a salt thereof in the cosmetics may have a small amount of anti-wrinkle effect, and at least 20% by weight of suveric acid or a salt thereof may exhibit known toxicity.
  • the composition containing substeric acid or a salt thereof of the present invention is a functional cosmetic that provides an effect of improving skin wrinkles, improving skin moisturizing, removing skin dead skin, enhancing skin elasticity, improving skin wrinkles, inhibiting erythema and / or improving skin photoaging. It can be usefully used as a material for health functional food, medicine or quasi-drugs.
  • the term "cosmetic composition” is a composition comprising the compound, the formulation may be in any form.
  • the cosmetic preparation prepared using the composition may be a nourishing cream, eye cream, massage cream, cream such as cleansing cream, pack, lotion such as nutrient lotion, essence, softening lotion, and lotion such as nourishing lotion.
  • Powders, foundations, makeup bases, and the like and may be prepared and commercialized in any of these formulations to achieve the object of the present invention, and are not limited to the above examples.
  • the cosmetic composition according to the present invention can be formulated by a conventional cosmetic preparation method.
  • the cosmetics of the present invention include skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisturizing lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, essence, pack, mask pack, mask sheet It may have one of the formulations selected from the group consisting of exfoliants, soaps, shampoos, cleansing foams, cleansing lotions, cleansing creams, body lotions, body cleansers, emulsions, press powders, loose powders and eye shadows.
  • the cosmetic composition of the present invention may include other additives such as excipients, carriers, etc. in addition to suveric acid or salts thereof, and it is possible to apply and formulate as needed the usual ingredients to be used in general skin cosmetics.
  • the cosmetic composition of the present invention may further include a transdermal penetration enhancer.
  • transdermal penetration enhancer is a composition that allows a desired component to penetrate into the blood vessel cells of the skin at a high absorption rate.
  • phospholipid components, liposome components and the like used in lecithin cosmetics are included, but are not limited to these.
  • oil which can be mainly used as an oil phase component
  • one or more selected from vegetable oil, mineral oil, silicone oil and synthetic oil can be used. More specifically, mineral oil, cyclomethicone, squalane, octyldodecyl myristate, olive oil, Vitis binifera seed oil, macadamia nut oil, glyceryl octanoate, castor oil, ethylhexyl isononanoate, dimethicone Chicon, cyclopentasiloxane, sunflower seed oil and the like can be used.
  • a surfactant may be used conventional surfactants such as nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, phospholipids, and the like, specifically, sorbitan sesquinolate, polysorbate 60 , Glyceryl stearate, lipophilic glyceryl stearate, sorbitan oleate, sorbitan stearate, die-cetyl phosphate, sorbitan stearate / sucrosecoate, glyceryl stearate / polyethylene glycol-100 Stearate, ceteareth-6 oleate, arachidyl alcohol / behenyl alcohol / arachidyl glucoside, polypropylene glycol-26-butes-26 / polyethylene glycol-40 hydrogenated castor oil, etc.
  • surfactants may be used conventional surfactants such as nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric
  • alcohols having 12 to 20 carbon atoms such as cetyl alcohol, stearyl alcohol, octyldodecanol, isostearyl alcohol, etc. may be used alone or in combination of one or more thereof.
  • the aqueous phase component may further add 0.001 to 5% by weight of one or more thickeners such as carbomer, xanthan gum, bentonite, magnesium aluminum silicate, cellulose gum, dextrin palmitate and the like to adjust the viscosity or hardness of the aqueous phase.
  • thickeners such as carbomer, xanthan gum, bentonite, magnesium aluminum silicate, cellulose gum, dextrin palmitate and the like to adjust the viscosity or hardness of the aqueous phase.
  • the cosmetic composition of the present invention if necessary, active ingredients such as higher fatty acids, vitamins, sunscreens, antioxidants (butylhydroxyanisole, propyl gallic acid, elixolic acid, tocopheryl acetate, butylated hydroxy) Toluene), preservatives (methylparaben, butylparaben, propylparaben, phenoxyethanol, imidazolidinylurea, chlorphenesin, etc.), colorants, pH adjusters (triethanolamine, citric acid, citric acid, sodium citrate, malic acid, Sodium malic acid, fmaric acid, sodium pramate, succinic acid, sodium succinate, sodium hydroxide, sodium monohydrogen phosphate, etc., moisturizers (glycerine, sorbitol, propylene glycol, butylene glycol, hexylene glycol, diglycerin , Betaine, glycerin-26, methylgluse-20 and the like), lubric acid,
  • the cosmetic composition of the present invention further comprises a substance capable of auxiliaryly providing essential nutrients to the skin, and may preferably contain auxiliary agents including, but not limited to, natural flavors, cosmetic flavors, or herbal medicines. have.
  • the cosmetic composition of the present invention may further comprise a skin wrinkle improvement component or skin elasticity enhancing component.
  • the specific skin wrinkle improving component or skin elasticity enhancing component may be any one or more selected from the group consisting of vitamin C, retinoic acid, TGF, protein from animal placenta, betulinic acid and chlorella extract, most preferably Vitamin C.
  • the amount of collagen is measured to rise to a higher value than when treated with suveric acid or vitamin C alone It was confirmed that the effect was shown (Fig. 1).
  • the present invention also provides a skin moisturizing improvement, skin exfoliation, skin elasticity improvement, erythema suppression, wrinkle improvement and / or skin photoaging improvement effect, which contain suveric acid or a food acceptable salt thereof as an active ingredient.
  • a nutraceutical composition which contain suveric acid or a food acceptable salt thereof as an active ingredient.
  • the term "health functional food” refers to a food prepared and processed in the form of tablets, capsules, powders, granules, liquids and pills using raw materials or ingredients having useful functions for the human body.
  • 'functional' means to obtain a useful effect for health purposes such as nutrient control or physiological action on the structure and function of the human body.
  • the health functional food of the present invention can be prepared by a method commonly used in the art, and the preparation can be prepared by adding raw materials and ingredients commonly added in the art.
  • the formulation of the health functional food can also be prepared without limitation as long as the formulation is recognized as a health functional food.
  • the health functional food composition of the present invention has the advantage that there is no side effect that can occur when taking long-term use of the drug, unlike foods as a raw material, and excellent portability, improve skin moisturizing, skin exfoliation, skin elasticity Ingestion may be taken as an adjuvant to promote erythema suppression, skin wrinkle improvement and / or skin photoaging improvement.
  • the dietary supplement composition of the present invention may be prepared in any one formulation selected from the group consisting of tablets, granules, powders, capsules, liquid solutions and rings.
  • the health functional food composition according to the present invention may be formulated in the form of powder, liquid, tablets, soft capsules, granules, tea bags, instant teas or drinks by including suveric acid as an active ingredient.
  • the content of suveric acid as an active ingredient can be suitably determined according to the purpose of use (prevention or improvement).
  • the amount of suveric acid included in the nutraceutical composition may be added at 0.1 to 90% by weight of the total food weight. However, in the case of prolonged intake for health and hygiene purposes or health control purposes, the amount may be below the above range.
  • nutraceutical composition according to the present invention in addition to suveric acid, other ingredients that can give a synergistic effect to the main effect, preferably within the range that does not impair the main effect of the present invention, for example, vitamin C Compounds for improving wrinkles such as or green tea extracts, mulberry extract, licorice extract, lettuce extract, betel nut extract, golden extract, wild ginseng extract may also contain natural products.
  • vitamin C Compounds for improving wrinkles such as or green tea extracts, mulberry extract, licorice extract, lettuce extract, betel nut extract, golden extract, wild ginseng extract may also contain natural products.
  • the dietary supplement composition formulated in the form as described above may be added to the food as it is or used with other foods or food ingredients, and may be appropriately used according to conventional methods.
  • foods include drinks, meats, sausages, breads, biscuits, rice cakes, chocolate, candy, snacks, confectionery, pizza, ramen, dairy products including other noodles, gums, ice creams, various soups, beverages, alcoholic beverages and vitamin complexes. , Dairy products and dairy products, and all functional foods in the conventional sense.
  • the health functional food composition of the present invention when the health functional food composition of the present invention is a drink, it contains suveric acid as an essential ingredient in the indicated ratio, and there are no particular limitations on other ingredients used for the manufacture of other drinks, and various flavors such as ordinary drinks.
  • Agent or natural carbohydrate and the like may be included as additional components.
  • natural carbohydrates include monosaccharides such as glucose, fructose and the like; Disaccharides such as maltose, sucrose and the like; And conventional sugars such as polysaccharides such as dextrin, cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol.
  • a natural flavoring agent such as a natural flavoring agent, a synthetic flavoring agent, etc.
  • the proportion of such natural carbohydrates is generally about 1 to 20 g, preferably about 5 to 12 g per 100 ml of the composition of the present invention.
  • the nutraceutical composition of the present invention is a variety of nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, coloring and neutralizing agents (such as cheese, chocolate), pectic acid and salts thereof, alginic acid And salts thereof, organic acids, protective colloid thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated drinks, and the like.
  • the food composition of the present invention may contain a pulp for producing natural fruit juice and fruit juice beverage and vegetable beverage. These components can be used independently or in combination. The proportion of such additives is not so critical but is generally selected from the range of 0.1 to about 20 parts by weight per 100 parts by weight of subric acid of the present invention.
  • the present invention also provides an quasi-drug or pharmaceutical composition having the effect of improving skin moisturizing, removing skin dead skin, enhancing skin elasticity, inhibiting erythema, improving skin wrinkles and / or improving skin photoaging, including suveric acid or a salt thereof as an active ingredient. do.
  • the pharmaceutical composition is a wrinkle improving component known in the art, any one or more selected from the group consisting of vitamin C, retinoic acid, TGF, protein from animal placenta, betulinic acid and chlorella extract It may further comprise a skin wrinkle improving ingredient.
  • the additional skin wrinkle improving component may be included in 0.0001 to 10% by weight relative to the total weight of the composition, the content range is based on requirements such as collagen synthesis promoting activity, skin safety, ease of formulation of the compound of Formula 1 Can be adjusted accordingly.
  • composition for improving skin wrinkles and elasticity of the present invention may further comprise a pharmaceutically acceptable carrier.
  • Pharmaceutically acceptable carriers may contain various components such as buffers, sterile water for injection, general saline or phosphate buffered saline, sucrose, histidine, salts, polysorbates and the like.
  • the pharmaceutical composition of the present invention may be administered orally or parenterally, and may be administered in the form of a general pharmaceutical preparation, for example, in various formulations, orally and parenterally, in the case of clinical administration.
  • Diluents or excipients such as extenders, binders, wetting agents, disintegrants, surfactants and the like.
  • Solid preparations for oral administration include tablets, pills, powders, granules, capsules, and the like, and such solid preparations include at least one excipient in the pharmaceutical composition of the present invention, for example, starch, calcium carbonate, It may be prepared by mixing sucrose or lactose, gelatin and the like.
  • Oral liquid preparations include suspensions, solvents, emulsions, and syrups, and may include various excipients, such as wetting agents, sweeteners, fragrances, and preservatives, in addition to commonly used simple diluents such as water and liquid paraffin. .
  • Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized preparations, suppositories.
  • non-aqueous solvent and the suspension solvent propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like can be used.
  • base of the suppository witepsol, macrogol, tween 61, cacao butter, laurin butter, glycerogelatin and the like can be used.
  • the pharmaceutical composition of the present invention may provide a desirable skin moisturizing improvement, skin exfoliation, skin elasticity improvement, erythema suppression, wrinkle improvement or skin photoaging improvement effect when an effective amount of suveric acid or a pharmaceutically acceptable salt thereof is included.
  • an effective amount of suveric acid or a pharmaceutically acceptable salt thereof is included.
  • the term 'effective amount' means an amount of a compound capable of inhibiting or inhibiting generation of wrinkles on the skin or alleviating wrinkles already produced.
  • the effective amount of suveric acid or a pharmaceutically acceptable salt thereof contained in the composition of the present invention will vary depending on the form in which the composition is commercialized, the method by which the compound is applied to the skin and the time it stays on the skin.
  • subvertic acid or a pharmaceutical composition thereof is used at a higher concentration than when it is commercialized as a cosmetic product that is applied to the skin on a daily basis. May be included as an acceptable salt.
  • the term "quasi drug” used in the present invention refers to articles that have a lesser action than drugs among those used for the purpose of diagnosing, treating, ameliorating, alleviating, treating or preventing diseases of humans or animals.
  • the drug is used for the purpose of medicine, and it includes a product used for the treatment or prevention of diseases of humans and animals, and a product having a slight or no direct action on the human body.
  • the quasi-drug composition of the present invention is used for the purpose of improving skin moisturizing, removing skin dead skin, enhancing skin elasticity, suppressing erythema, improving skin wrinkles and / or improving skin photoaging, and is not particularly limited in the formulation thereof.
  • It may be a cosmetic composition having a formulation of a flexible cosmetics, nourishing cosmetics, massage creams, nutrition creams, packs, mask packs, mask sheets, gels or skin adhesive cosmetics, and also lotions, ointments, gels, creams, patches or sprays.
  • It may be a transdermal dosage form such as
  • the quasi-drug composition may be optionally selected and blended with other ingredients according to the formulation or purpose of use of other quasi-drugs.
  • the mixed amount of the active ingredient can be suitably determined depending on the purpose of use (inhibition or relaxation).
  • it may include conventional adjuvants such as thickeners, stabilizers, solubilizers, vitamins, pigments and flavorings, carriers and the like.
  • the content of suveric acid or salt thereof of the present invention is preferably 0.0001 to 20% by weight, respectively, based on the total weight of the quasi-drug composition. If the content exceeds 20% by weight, the color and stability of the composition are inferior. If the content is less than 0.0001%, the effect is minimal.
  • Primary dermal fibroblasts (normal, human, neonatal, ATCC No. PCS-201-010) were purchased from ATCC (Manassas, VA, USA) and used. The purchased cells were incubated in a 37%, 5% CO 2 incubator using a fibroblast growth medium (Promo Cell, Heidelberg) and used for the experiment.
  • a human fibroblasts In order to examine the collagen biosynthesis performance 12-well-was added to the plate (well-plate) 1.0 ⁇ suberic acid and vitamin C to 10 6 cells / well Pipette at a concentration of 100 ⁇ M respectively for 24 hours, CO 2 Cultured in the incubator. After removing the medium of each well, washed once with PBS, and again put 1 ml of PBS was irradiated with ultraviolet B (UVB) at 20 mJ / cm 2 conditions. PBS of each well was replaced with medium again and cultured for 24 hours, and then the amount of procollagen secreted into the medium was measured using a procollagen type C-peptide EIA kit (Takara Bio, Japan). The standard solution included in the collagen measurement kit was diluted by concentration, and the absorbance was measured at 450 nm to prepare a standard concentration curve and calculate the amount of collagen produced.
  • UVB ultraviolet B
  • Collagen the main protein constituting the skin, is synthesized in the form of procollagen from fibroblasts present in the dermis and then secreted into the extracellular matrix. Procollagen secreted into the extracellular matrix is decomposed by the procollagen peptidase on the cell surface and formed into active collagen. Therefore, the activated collagen content can be determined by measuring the C-peptide content.
  • FIG. 1 represents the means ⁇ SEM of three measurements from three independent wells. Mean values in other alphabets indicate statistical significance (p ⁇ 0.05). Human skin fibroblasts were treated with UV radiation and treated with drugs to measure the amount of procollagen and procollagen type I C-peptide (PIP) secreted into the extracellular matrix.
  • PIP procollagen type I C-peptide
  • Example 2 Using Mouse Submersible Skin wrinkle improvement, moisturizing and elasticity efficacy evaluation
  • mice The five-week-old female albino hairless mice (Skh-1) used in this example were purchased from Orient Bio (Gyeonggi-do, Korea) and subjected to a one-week adaptation period as a solid feed. Experimental animals were divided into 4 groups and 5 animals were assigned to each group and used for the experiment. All experimental groups were divided into the normal control group (-UVB), the UV irradiation group (+ UVB), and the UV-irradiated subcutaneous (SA) or vitamin C (VitC) group. Feed and water were freely ingested during the breeding period, and the temperature was maintained at 22 ⁇ 1 °C and humidity at 60 ⁇ 5%, and the photoperiod and dark cycle were adjusted to 12 hours daily.
  • -UVB normal control group
  • SA UV irradiation group
  • SA subcutaneous
  • VitC vitamin C
  • the -UVB and + UVB groups consumed a diet formulated according to the AIN-93 rodent diet (Ree ves, PG et al., J Nutr, 123: 1939-1951, 1993).
  • the composition of the detailed experimental diet is shown in Table 1 below. The diet was fed with water between 10 am and 11 am daily, and dietary intake was measured daily.
  • UVB ultraviolet B
  • the UV irradiation dose was 73 mJ / cm 2 for the first week, 146 mJ / cm 2 for the second week, and from 3 to 10 weeks. Irradiation at 219 mJ / cm 2 .
  • body weight and skin thickness were measured every week, and photographs of the back skin were taken. Skin thickness was measured in the hip region of hairless mice using a digital micro caliper (Marathon Watch Company Ltd, Ontario, Canada). The caliper used for the measurement was able to measure up to 0.01 mm and the adjustment function to apply a constant force to the thickness was able to measure the thickness of the skin under the same force.
  • the skin of hairless mice subjected to UV irradiation for 10 weeks was made of silicone rubber to measure the extent of wrinkle formation. Attach a disk with a circular hole with a diameter of 1 cm to the back of the hairless mouse, mix the reagent for making a replica, thinly spread it on the back of the hairless mouse, dry it completely, and carefully remove the disk. was produced. Fabrication temperature of the replica plate was carried out in a constant temperature and humidity condition of 20 ⁇ 23 °C, humidity 45 ⁇ 50%, was used a silicon plate rubber impression material (Epigem, Seoul, Korea) for the production. Analysis of the simulated platen was performed using a computer image analyzer (Visioline VL650, CK electronic GmbH, Germany) for total wrinkle area, maximum wrinkle depth, mean depth and mean wrinkles. Four wrinkle indicator items such as mean length were analyzed.
  • mice The back skin tissue of hairless mice was extracted and fixed in 10% formalin. Then, Hema toxylin and eosin (H & E) and Masson's trichrome (M & T) staining were performed by Korean CFC (Gyeonggi-do, Korea), followed by optical microscope (IX71, Olympus, After observing using JPN, pictures were taken using a digital camera (DP71, Olympus, JPN).
  • Tissue was ground by adding 1 ml of Trizol solution per 0.1 g of back skin tissue, and centrifuged at 4, 12,000 xg for 10 minutes. The supernatant was transferred to a new tube and 200 ⁇ l of chloroform was added and vortexed. After repeating this process twice, the supernatant was transferred to a new tube and isoprophanol and supernatant were added at a 1: 1 ratio. After shaking vigorously 10 times and left at room temperature for 15 minutes, centrifugation was performed at 12,000 xg and 4 minutes for 10 minutes, the supernatant was removed, and 1 ml of 70% ethanol was added to the remaining precipitate, followed by 5 minutes at 7,500 xg and 4 minutes. Centrifugation was performed.
  • RNA pellet was dissolved using nuclease free water.
  • UV / VIS spectrophotometer Beckman coulter, DU730 was measured the concentration of RNA samples extracted at 260 nm and 280 nm wavelength, and the integrity of the RNA samples were confirmed by agarose gel electrophoresis.
  • CDNA was synthesized by reverse transcription using oligo dT primer and superscript reverse transcriptase (GIBCO BRL, Gaithersburg, MD, USA) on RNA samples extracted from the back skin tissue. PCR was performed using 5 'and 3' flanking sequences of the gene cDNA to be amplified as a template and cDNA obtained through reverse transcription. The primer sequences used are shown in [Table 2]. 1 ⁇ l of the amplified PCR product was electrophoresed on 1% agarose gel to confirm DNA band.
  • the values in FIG. 3 are mean ⁇ SEM of 5 mice, and the alphabet above the bar represents a significant difference by one-way ANOVA followed by Duncan's multiple range test (p ⁇ 0.05).
  • the + UVB control group was thicker and deeper than the normal UV-irradiated group (-UVB). It was observed that fine wrinkles were formed together with the wrinkles, and even though the sub-acid group was irradiated with UV of the same intensity, the wrinkles and the depth of the wrinkles were remarkably improved compared to the + UVB control group.
  • the SA group had a total wrinkle area of 48%, a maximum wrinkle depth of 32%, an average wrinkle depth of 28%, and an average wrinkle of the SA group compared to the + UVB group.
  • the length was significantly reduced by 56%, and the anti-wrinkle effect of suberic acid was similar to the anti-wrinkle effect observed in vitamin C (FIG. 5B).
  • the values in FIG. 5B are mean ⁇ SEM of 5 mice, and the alphabet above the bar represents a significant difference by one-way ANOVA followed by Duncan's multiple range test (p ⁇ 0.05). Therefore, it can be seen that the intake of suveric acid has an effect of significantly suppressing wrinkle formation by ultraviolet irradiation.
  • the + UVB control group significantly increased the skin thickness compared to the normal group (-UVB) that was not irradiated with UV rays, and ingested suveric acid. It was confirmed that the skin thickness was significantly reduced by 24% compared to the + UVB control (Fig. 6A).
  • the values in FIG. 6A are mean ⁇ SEM of 5 mice, with the alphabet above the bar representing a significant difference by one-way ANOVA followed by Duncan's multiple range test (p ⁇ 0.05).
  • the skin epidermal layer thickness of hairless mice by H & E staining of skin tissue was also observed that the + UVB control group thickened the skin epidermis layer compared to the normal group (-UVB) without UV irradiation. It was confirmed that the thickness of the epidermal layer thickened by was significantly reduced (FIG. 6B).
  • collagen fibers of + UVB group were weakly stained by aniline blue.
  • the density of collagen fibers was relatively dense and the arrangement was regular compared to the control group, and the staining by aniline blue was also stronger, thus closer to the normal group (-UVB) Was shown (Fig. 7).
  • Collagen types 1 and 3 are proteins that constitute the cytoplasmic components of the dermal layer, and in particular, type 1 collagen is present in the largest amount of extracellular matrix proteins present in skin connective tissue.
  • MMPs that catalyze collagen degradation
  • MMP types known to increase by UV rays are known as Nos. 1, 3, and 9.
  • MMP-1 is known to cut the middle of collagen fibers
  • MMP-3 and MMP-9 are known to play a role in subdividing and cutting the cut collagen fibers (Quan T. et al. Elevated matrix metalloproteinases and collagen fragmentation).
  • collagen type 1 ⁇ 1 and ⁇ 2 and collagen type 3 ⁇ 1 of + UVB control group were compared with normal group (-UVB) without UV irradiation.
  • the expression of MMP-1a and -1b, MMP-3, and MMP-9 genes were significantly increased.
  • the expression of collagen type 1 ⁇ 1 and ⁇ 2 and collagen type 3 ⁇ 1 was significantly increased in the suveric acid intake group compared to the + UVB control group, and MMP-1a and -1b, MMP-3, and MMP-9 gene expression were significantly increased.
  • Significantly decreased (FIG. 8). Therefore, it is thought that suveric acid inhibited wrinkle formation by UV irradiation by increasing collagen protein synthesis of skin tissue and inhibiting collagen fiber degradation.
  • suveric acid has the effect of preventing or alleviating skin wrinkles caused by ultraviolet rays, which may be usefully used as functional cosmetics, health functional foods, medicines or quasi-drugs in the future.
  • components 1 to 8 are first dissolved by heating at a temperature of 70 ° C., and components 9 to 13 are dissolved and dispersed in component 14, and emulsified by heating to 70 ° C. Thereafter, the emulsified product was cooled to a temperature of 56 ° C., and then component 15 dissolved in the fractionated component 9 was added thereto, stirred, and cooled to room temperature to prepare.
  • the cosmetic composition containing suveric acid or a cosmetically acceptable salt thereof of the present invention as an active ingredient has no skin side effects, and has excellent skin wrinkle improvement effect, increased synthesis of collagen protein, and inhibition of collagen fiber degradation. Excellent for improving skin wrinkles.
  • the skin moisture content was measured using a Koniometer in a constant temperature and humidity room at room temperature 25 ° C. and relative humidity 45% before application, and the Experimental Example 1 and Comparative Example 1 formulations of Table 3 were respectively left and right of the face. After 10 minutes of application, the skin was rested for 12 hours after application and 24 hours after application.
  • the measuring device measured the moisture content of the skin using a moisture content meter (coneometer; CM820, Courage Khazaka electronic GmbH, Germany) that measures the moisturizing power by measuring the electric capacity of the skin according to the moisture content of the skin.
  • the conniometer measures the amount of moisture present in the skin's epidermis by using a sensor to measure the degree of ions of the water and quantifies it to calculate the amount of moisture, and the measuring method is as follows.
  • the sensor was wiped with a tissue such as Kimwipe and then measured again.
  • the measurement of the skin angular mass was measured by using Charm view (Moritex, Japan) in a constant temperature and humidity room at room temperature 25 °C and relative humidity 45% before application, Experimental Example 1 and Comparative Example 1 of Table 3 The formulations were applied to the left and right sides of the face, respectively, and then the skin angular mass after 24 hours was measured and the amount of skin keratin reduction was calculated. Each value is shown in Table 6 below as an average value.
  • the nutritional cream of Experimental Example 1 containing suberic acid has an excellent skin keratinizing effect than the nutritional cream of Comparative Example 1 containing no subric acid.
  • the moisturizing effect is applied to the skin, the angular mass decreases.
  • the nourishing cream of Experimental Example 1 has a superior skin exfoliation effect than the nourishing cream of Comparative Example 1 due to its excellent water retention as demonstrated in Example 3-3. It is judged to indicate.
  • each of the experimental group (SA and Azelaic acid) and the control group (+ UVB) human dermal fibroblasts were irradiated with UV 30 mJ / cm 2, and treated with 100 ⁇ M of suberic acid (SA) and azelaic acid, respectively, The concentration of procollagen type I C-peptide (PIP) secreted into the extracellular matrix was measured.
  • SA suberic acid
  • PIP procollagen type I C-peptide
  • the collagen amount increased 52% significantly compared to the control cell (+ UVB) irradiated with ultraviolet rays, whereas the cells treated with azelaic acid (Azelaic acid) In, the amount of collagen increased only 13% compared to the control (+ UVB).
  • the collagen synthesis ability of the present invention sub acid was about 4 times superior to azelaic acid, thereby demonstrating the excellent skin activity effect of sub acid.
  • Example 2-1 Subersan 1000 mg Vitamin mixtures Quantity Vitamin A Acetate 1.0 mg Vitamin E 0.13 mg Vitamin B1 0.15 mg Vitamin B2 0.5 mg Vitamin B6 0.2 ⁇ g Vitamin B12 10 mg Vitamin c 10 ⁇ g Biotin 1.7 mg Nicotinic acid amide 50 ⁇ g Folic acid 0.5 mg Calcium Pantothenate Quantity Mineral mixture Quantity Ferrous sulfate 1.75 mg Zinc oxide 0.82 mg Magnesium carbonate 25.3 mg Potassium phosphate monobasic 15 mg Dibasic Potassium Phosphate 55 mg Potassium citrate 90 mg Calcium carbonate 100 mg Magnesium chloride 24.8 mg
  • composition ratio of the vitamin and mineral mixture is a composition that is relatively suitable for the health functional food is mixed in a preferred embodiment
  • the compounding ratio may be arbitrarily modified, and the above ingredients are mixed according to a conventional health functional food manufacturing method.
  • the granules may be prepared and used for preparing the nutraceutical composition according to a conventional method.
  • composition ratio is a composition that is relatively suitable for the preferred beverage in a preferred embodiment, the compounding ratio may be arbitrarily modified according to regional and ethnic preferences such as demand hierarchy, demand country, and usage.
  • the capsule containing gebergine was prepared by filling a gelatin capsule in accordance with a conventional capsule preparation method.
  • the ring was prepared so as to be 4 g per ring according to a conventional ring production method.

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Abstract

La présente invention concerne une composition cosmétique, une composition alimentaire naturelle fonctionnelle, un produit médical ou une composition parapharmaceutique contenant de l'acide subérique ou un sel de celui-ci utilisé comme principe actif, et ayant comme effets d'atténuer les rides de la peau, d'améliorer l'hydratation de la peau, l'exfoliation de la peau, d'améliorer l'élasticité de la peau, d'atténuer les rides de la peau, d'inhiber un érythème et d'atténuer le photovieillissement de la peau. L'acide subérique ou un sel de celui-ci selon la présente invention présente les activités d'augmentation du taux d'hydratation de la peau, de réduction de la proportion d'évaporation de l'humidité de la peau, d'augmentation de la quantité de sécrétion de procollagène, de promotion de la biosynthèse du collagène, d'inhibition des lésions aux fibres de collagène, d'inhibition de la décomposition des fibres de collagène, d'inhibition d'un érythème et d'inhibition d'une pachydermie de la peau, ce qui lui permet d'être utilisé de manière utile en tant que substance pour un produit cosmétique fonctionnel, un aliment naturel fonctionnel, un produit médical ou un produit parapharmaceutique, ou analogues, offrant comme effets d'améliorer l'hydratation de la peau, l'exfoliation de la peau, d'améliorer l'élasticité de la peau, d'atténuer les rides de la peau, d'inhiber un érythème, d'atténuer les rides de la peau et/ou d'atténuer le photovieillissement de la peau.
PCT/KR2017/004999 2016-06-13 2017-05-15 Composition contenant de l'acide subérique ou un sel de celui-ci utilisé comme principe actif, et ayant comme effets d'améliorer l'hydratation de la peau, l'exfoliation de la peau, d'améliorer l'élasticité de la peau, d'inhiber un érythème, d'atténuer les rides de la peau, ou d'atténuer le photovieillissement de la peau WO2017217660A1 (fr)

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KR1020160073324A KR101742219B1 (ko) 2016-06-13 2016-06-13 수베르산 또는 이의 염을 유효성분으로 함유하는 피부보습 개선, 피부각질 제거, 피부탄력 증진, 홍반 억제, 피부주름 개선 또는 피부광노화 개선 효과를 갖는 조성물
KR10-2016-0073324 2016-06-13
KR1020170049615A KR101754556B1 (ko) 2017-04-18 2017-04-18 수베르산 또는 이의 염을 유효성분으로 함유하는 피부보습 개선 또는 피부탄력 증진 효과를 갖는 조성물
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6406708B1 (en) * 1998-05-12 2002-06-18 Interhealth Ab Therapeutic compositions
US20040258652A1 (en) * 2003-06-18 2004-12-23 Goldschmidt Ag Hair treatment compositions and hair after-treatment compositions for protection against damage by chemical treatment and for the repair of already damaged hair comprising as active substances alkylguanidine compounds
EP2583977A1 (fr) * 2010-06-15 2013-04-24 National University Corporation Nara Institute of Science and Technology Collagène modifié par du rétinol, méthode pour sa production et composition externe pour la peau le contenant
KR101516444B1 (ko) * 2007-04-12 2015-05-07 아르끄마 프랑스 미세 분말을 포함하는 화장 조성물
US9265725B2 (en) * 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6406708B1 (en) * 1998-05-12 2002-06-18 Interhealth Ab Therapeutic compositions
US9265725B2 (en) * 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US20040258652A1 (en) * 2003-06-18 2004-12-23 Goldschmidt Ag Hair treatment compositions and hair after-treatment compositions for protection against damage by chemical treatment and for the repair of already damaged hair comprising as active substances alkylguanidine compounds
KR101516444B1 (ko) * 2007-04-12 2015-05-07 아르끄마 프랑스 미세 분말을 포함하는 화장 조성물
EP2583977A1 (fr) * 2010-06-15 2013-04-24 National University Corporation Nara Institute of Science and Technology Collagène modifié par du rétinol, méthode pour sa production et composition externe pour la peau le contenant

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