WO2017209830A2 - Non-contact laser ultrasound system - Google Patents

Non-contact laser ultrasound system Download PDF

Info

Publication number
WO2017209830A2
WO2017209830A2 PCT/US2017/022503 US2017022503W WO2017209830A2 WO 2017209830 A2 WO2017209830 A2 WO 2017209830A2 US 2017022503 W US2017022503 W US 2017022503W WO 2017209830 A2 WO2017209830 A2 WO 2017209830A2
Authority
WO
WIPO (PCT)
Prior art keywords
laser
vibrometer
skin
illuminating
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2017/022503
Other languages
French (fr)
Other versions
WO2017209830A3 (en
Inventor
Robert W. HAUPT
Anthony SAMIR
Charles M. WYNN
Jae H. Kyung
Kevin W. Holman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of WO2017209830A2 publication Critical patent/WO2017209830A2/en
Anticipated expiration legal-status Critical
Publication of WO2017209830A3 publication Critical patent/WO2017209830A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
    • A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0833—Clinical applications involving detecting or locating foreign bodies or organic structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0858—Clinical applications involving measuring tissue layers, e.g. skin, interfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/42—Details of probe positioning or probe attachment to the patient
    • A61B8/4209—Details of probe positioning or probe attachment to the patient by using holders, e.g. positioning frames
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01H—MEASUREMENT OF MECHANICAL VIBRATIONS OR ULTRASONIC, SONIC OR INFRASONIC WAVES
    • G01H9/00—Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves by using radiation-sensitive means, e.g. optical means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0064—Body surface scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/485—Diagnostic techniques involving measuring strain or elastic properties

Definitions

  • This invention relates to ultrasound imaging technology and, more particularly, to ultrasound system that eliminates contact of a probe with the surface of a body.
  • Ultrasound is an ideal imaging modality used in medical practice: it is portable, inexpensive, has no known bio-effects, and produces images with excellent spatial and temporal resolution. Despite these advantages, MRI and CT are the dominant modalities used for most medical imaging requirements while accepting high cost and imposed health risks. Ultrasound is typically acquired with hand held transducers that depend on the operator's applied pressure and selection of angle planes with no fixed acquisition frame. These factors lead to inter-operator variability that introduces significant image distortion and limits image accuracy and confidence.
  • the American Thyroid Association guidelines require an increase in thyroid nodule volume of more than 50%, or an increase of more than 20% in two or more measured dimensions, prior to recommending biopsy when using conventional ultrasound. This is because interoperator variability is so high, large increases in nodule size are necessary before nodule growth can be confidently diagnosed.
  • An object of the invention is to mitigate ultrasound inter-operator and operator variability, and possibly patient discomfort, using a standoff optical concept that generates and measures ultrasonic waves without patient contact.
  • the non-contact, ultrasound imaging system includes a pulsed near infrared scanning laser source for illuminating a surface of a structure to generate ultrasonic elastic waves that propagate into the structure.
  • a laser Doppler vibrometer is provided to measure vibration of the surface resulting from the propagating ultrasonic waves in the structure.
  • a data acquisition module processes data from the vibrometer to construct an image of the structure.
  • the structure is often a human body.
  • the system further includes a camera to record locations of the illuminating and vibrometer beam locations.
  • a suitable pulsed near infrared laser is a Q- switched laser.
  • the Q-switched laser may operate at a 1-10 kilohertz framerate.
  • the structure is a biological entity and the surface is skin.
  • the system components may be supported by an x-y translation stage mounted on a stand that fits over the structure.
  • a suitable laser wavelength for illumination is 1550 cm.
  • Fig. 1 is a schematic illustration of an embodiment the ultrasound imaging system disclosed herein.
  • Fig. 2 is a schematic illustration showing the creation of ultrasonic waves and measuring vibrating skin surface.
  • Fig. 3 includes ultrasound images of a foreign body embedded in a muscle tissue.
  • Fig. 4 is a schematic illustration of the system of the invention showing it mounted on a frame that fits over a subject being probed. Description of the Preferred Embodiment
  • a pulsed near IR source (Q-switched laser) converts optical energy to ultrasonic waves within the skin surface via photoacoustic (PA) mechanisms.
  • Laser Doppler vibrometry (LDV) is then used to measure probing ultrasound signals that return to the skin surface.
  • a short wavelength (SWIR) or visible spectrum camera is used to record the image of the excitation and LDV beam locations on the patient target.
  • a frame rate of 1 - 10 kiloHertz is adequate to capture relevant patient motion and jitter during the ultrasonic data acquisition process.
  • a lidar system or optical camera set can also be used to map the 3D patient surface topography and then used to correct for transmitter and receiver geometries when applied to data and image processing.
  • PA mechanisms can produce the full compilation of ultrasonic waves including compressional, shear, Rayleigh, and Love wave components. Using information from these various wave types yields not only anatomical images in the body, but can also provide elastic property distributions, in-situ that are useful for several emerging fields in medicine.
  • the system disclosed herein induces a probing ultrasonic wave initiated with an optical short pulse that triggers photoacoustic phenomena.
  • This short pulse converts optical energy into mechanical energy via thermal loading, causing the optical absorbing material— human skin or structure surface— to locally deform very rapidly (stress-strain yields a propagating elastic wave) and launch the probing ultrasonic wave that can travel several inches into the body and back.
  • the probing wave reflects off varying internal anatomical features with depth and emerges containing the subject interior image signal.
  • the return signal is then measured at the skin or structure surface with a highly-sensitive laser Doppler vibrometer (LDV).
  • LDV laser Doppler vibrometer
  • apparatus 10 includes an optical excitation source 12, a laser sensing receiver portion 14 and a camera portion 16.
  • the laser 12 which may be a Q-switched laser illuminates a surface region 18 on a human body 20.
  • the skin is thermally deformed rapidly resulting in a propagating elastic wave into the body 20.
  • the ultrasonic wave travels into the body and is reflected back to the skin where the laser sensing receiver 14 detects the vibration at the surface.
  • the laser sensing receiver 14 is preferably a highly sensitive laser Doppler vibrometer (LDV).
  • LDV laser Doppler vibrometer
  • the apparatus 10 may also include a data acquisition module for receiving the vibrometer information to create an image.
  • Fig. 2 illustrates how the system works.
  • a pulsed optical source generates ultrasound through photoacoustic (PA) mechanisms.
  • the laser receiver measures the vibrating return on the skin surface.
  • PA photoacoustic
  • the left side panel shows a one inch thick muscle sample supported on a metal tabletop.
  • a metal sliver is embedded one half inch below the muscle surface without disturbing the muscle surface. Its image is shown in the middle panel of Fig. 3.
  • the rightmost panel in Fig. 3 shows a wound reflection after the metal sliver has been removed. The measurement was made from approximately a one meter standoff from the muscle specimen.
  • Fig. 4 shows the apparatus 10 supported on an x-y stage which is supported by the frame or stand 22.
  • the stand 22 is useful in military field operations.
  • the components shown in Fig. 4 include an excitation laser to launch ultrasonic waves, a fast steering mirror that directs the excitation laser and a receiving laser vibrometer that measures the ultrasonic return on the patient 10 skin surface.
  • the components also include a shortwave infrared
  • the apparatus 10 also includes an acquisition system that records, stores and processes the acquired ultrasonic data to form the ultrasonic images.
  • An optical camera can also be used to provide a fixed reference frame when using a simple red or green eye- safe laser.
  • Lidar can also be used to provide a topographical reference of the patient surface that can be updated at a rate of 1 kilohertz to aid in data processing and image processing.
  • the Q-switched laser generates short optical pulses of approximately 3 nsec at a 1550 nm optical wavelength.
  • a suitable beam diameter at a skin 135 surface is 1-2 mm.
  • Optical fluence level is 21 mJ/cm 2 .
  • the laser may be a Continuum Panther OPO or a Continuum Minilite YAG Q-switched laser, for example.
  • a suitable Q-switched Doppler vibrometer is a Polytec OFV 5000 LDV or a custom built unit.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Acoustics & Sound (AREA)
  • General Physics & Mathematics (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

Non-contact ultrasound imaging system. The system includes a pulsed near infrared scanning laser source for illuminating a surface of a structure to generate ultrasonic elastic waves that propagate into the structure. A laser Doppler vibrometer measures vibration of the surface caused by the propagating ultrasonic waves in the structure and a data acquisition module processes data from the vibrometer to construct an image of the structure.

Description

NON-CONTACT LASER ULTRASOUND SYSTEM
This application claims priority to United States Application serial number 15/456,842 filed March 13, 2017 and Provisional Application serial number 62/309,497 filed on March 17, 2016, the contents of both are incorporated herein by reference in their entirety.
"This invention was made with Government support under Contract No. FA8721-05- C-0002 awarded by the U.S. Air Force. The Government has certain rights in the invention."
Background of the Invention
This invention relates to ultrasound imaging technology and, more particularly, to ultrasound system that eliminates contact of a probe with the surface of a body. Ultrasound is an ideal imaging modality used in medical practice: it is portable, inexpensive, has no known bio-effects, and produces images with excellent spatial and temporal resolution. Despite these advantages, MRI and CT are the dominant modalities used for most medical imaging requirements while accepting high cost and imposed health risks. Ultrasound is typically acquired with hand held transducers that depend on the operator's applied pressure and selection of angle planes with no fixed acquisition frame. These factors lead to inter-operator variability that introduces significant image distortion and limits image accuracy and confidence. For example, the American Thyroid Association guidelines require an increase in thyroid nodule volume of more than 50%, or an increase of more than 20% in two or more measured dimensions, prior to recommending biopsy when using conventional ultrasound. This is because interoperator variability is so high, large increases in nodule size are necessary before nodule growth can be confidently diagnosed. The European
Organization for Research and Treatment of Cancer (EORTC) Response Evaluation Criteria In Solid Tumors (RECIST) guidelines do not permit the use of ultrasound tumor
measurements for the follow-up of cancer, owing to high interobserver variability. This means that patients with cancer must be followed up with CT scans (high cost and ionizing radiation) or MRI scans (high cost).
Further, standardized contact transducer systems can cause patient risk, discomfort or pain in cases involving trauma, damaged or burned skin, bleeding, infection-susceptible regions, delicate surgical configurations or for difficult-to-reach areas. An object of the invention is to mitigate ultrasound inter-operator and operator variability, and possibly patient discomfort, using a standoff optical concept that generates and measures ultrasonic waves without patient contact. Summary of the Invention
The non-contact, ultrasound imaging system according to the invention includes a pulsed near infrared scanning laser source for illuminating a surface of a structure to generate ultrasonic elastic waves that propagate into the structure. A laser Doppler vibrometer is provided to measure vibration of the surface resulting from the propagating ultrasonic waves in the structure. A data acquisition module processes data from the vibrometer to construct an image of the structure. The structure is often a human body.
In a preferred embodiment, the system further includes a camera to record locations of the illuminating and vibrometer beam locations. A suitable pulsed near infrared laser is a Q- switched laser. The Q-switched laser may operate at a 1-10 kilohertz framerate. In another preferred embodiment, the structure is a biological entity and the surface is skin. The system components may be supported by an x-y translation stage mounted on a stand that fits over the structure. A suitable laser wavelength for illumination is 1550 cm.
Brief Description of the Drawing
Fig. 1 is a schematic illustration of an embodiment the ultrasound imaging system disclosed herein.
Fig. 2 is a schematic illustration showing the creation of ultrasonic waves and measuring vibrating skin surface. Fig. 3 includes ultrasound images of a foreign body embedded in a muscle tissue. Fig. 4 is a schematic illustration of the system of the invention showing it mounted on a frame that fits over a subject being probed. Description of the Preferred Embodiment
A pulsed near IR source (Q-switched laser) converts optical energy to ultrasonic waves within the skin surface via photoacoustic (PA) mechanisms. Laser Doppler vibrometry (LDV) is then used to measure probing ultrasound signals that return to the skin surface. A short wavelength (SWIR) or visible spectrum camera is used to record the image of the excitation and LDV beam locations on the patient target. A frame rate of 1 - 10 kiloHertz is adequate to capture relevant patient motion and jitter during the ultrasonic data acquisition process. A lidar system or optical camera set can also be used to map the 3D patient surface topography and then used to correct for transmitter and receiver geometries when applied to data and image processing.
The disclosed system produces useful ultrasound images in tissue while operating within eye and skin safety limits. Additionally, PA mechanisms can produce the full compilation of ultrasonic waves including compressional, shear, Rayleigh, and Love wave components. Using information from these various wave types yields not only anatomical images in the body, but can also provide elastic property distributions, in-situ that are useful for several emerging fields in medicine.
The system disclosed herein induces a probing ultrasonic wave initiated with an optical short pulse that triggers photoacoustic phenomena. This short pulse converts optical energy into mechanical energy via thermal loading, causing the optical absorbing material— human skin or structure surface— to locally deform very rapidly (stress-strain yields a propagating elastic wave) and launch the probing ultrasonic wave that can travel several inches into the body and back. The probing wave reflects off varying internal anatomical features with depth and emerges containing the subject interior image signal. The return signal is then measured at the skin or structure surface with a highly-sensitive laser Doppler vibrometer (LDV). The disclosed system does not require coupling gel or any other substance at the skin or target surface to enhance signal transmission as is the case with contact ultrasonic transducers used in routine medical practice. With reference to Fig. 1, apparatus 10 includes an optical excitation source 12, a laser sensing receiver portion 14 and a camera portion 16. In operation, the laser 12 which may be a Q-switched laser illuminates a surface region 18 on a human body 20. The skin is thermally deformed rapidly resulting in a propagating elastic wave into the body 20. The ultrasonic wave travels into the body and is reflected back to the skin where the laser sensing receiver 14 detects the vibration at the surface. The laser sensing receiver 14 is preferably a highly sensitive laser Doppler vibrometer (LDV). The apparatus 10 may also include a data acquisition module for receiving the vibrometer information to create an image. Fig. 2 illustrates how the system works. A pulsed optical source generates ultrasound through photoacoustic (PA) mechanisms. The laser receiver measures the vibrating return on the skin surface.
With reference now to Fig. 3, the left side panel shows a one inch thick muscle sample supported on a metal tabletop. A metal sliver is embedded one half inch below the muscle surface without disturbing the muscle surface. Its image is shown in the middle panel of Fig. 3. The rightmost panel in Fig. 3 shows a wound reflection after the metal sliver has been removed. The measurement was made from approximately a one meter standoff from the muscle specimen.
Fig. 4 shows the apparatus 10 supported on an x-y stage which is supported by the frame or stand 22. The stand 22 is useful in military field operations. The components shown in Fig. 4 include an excitation laser to launch ultrasonic waves, a fast steering mirror that directs the excitation laser and a receiving laser vibrometer that measures the ultrasonic return on the patient 10 skin surface. The components also include a shortwave infrared
(SWIR) camera 16 to image the skin surface and laser contact points. The apparatus 10 also includes an acquisition system that records, stores and processes the acquired ultrasonic data to form the ultrasonic images. An optical camera can also be used to provide a fixed reference frame when using a simple red or green eye- safe laser. Lidar can also be used to provide a topographical reference of the patient surface that can be updated at a rate of 1 kilohertz to aid in data processing and image processing. In a preferred embodiment, the Q-switched laser generates short optical pulses of approximately 3 nsec at a 1550 nm optical wavelength. A suitable beam diameter at a skin 135 surface is 1-2 mm. Optical fluence level is 21 mJ/cm2. The laser may be a Continuum Panther OPO or a Continuum Minilite YAG Q-switched laser, for example. A suitable Q-switched Doppler vibrometer is a Polytec OFV 5000 LDV or a custom built unit.
Modifications and variations of the invention disclosed herein will be readily apparent 140 to those of skill in the art and it is intended that all such modifications and variations be
included within the scope of the appended claims.
What is claimed is:

Claims

What is claimed is: 1. Non-contact ultrasound imaging system comprising: a pulsed near infrared scanning laser source for illuminating a surface of a structure to generate ultrasonic elastic waves that propagate into the structure; a laser Doppler vibrometer to measure vibration of the surface from the propagating ultrasonic waves in the structure; and a data acquisition module for processing data from the vibrometer to construct an image of the structure.
2. The system of claim 1 further including a camera to record locations of illuminating and vibrometer beam locations.
3. The system of claim 1 wherein the pulsed near infrared scanning laser is a Q-switched laser.
4. The system of claim 3 wherein the Q-switched laser operates at a 1-10 kilohertz framerate.
5. The system of claim 1 wherein the structure is a biological entity and the surface is skin.
6. The system of claim 1 wherein the system components are supported by an x-y translation stage mounted on a stand that fits over the structure.
7. The system of claim 1 wherein the laser source operates at approximately a 1500 nm wavelength.
PCT/US2017/022503 2016-03-17 2017-03-15 Non-contact laser ultrasound system Ceased WO2017209830A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662309497P 2016-03-17 2016-03-17
US62/309,497 2016-03-17
US15/456,842 US20170265751A1 (en) 2016-03-17 2017-03-13 Non-contact laser ultrasound system
US15/456,842 2017-03-13

Publications (2)

Publication Number Publication Date
WO2017209830A2 true WO2017209830A2 (en) 2017-12-07
WO2017209830A3 WO2017209830A3 (en) 2019-04-04

Family

ID=59848163

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2017/022503 Ceased WO2017209830A2 (en) 2016-03-17 2017-03-15 Non-contact laser ultrasound system

Country Status (2)

Country Link
US (1) US20170265751A1 (en)
WO (1) WO2017209830A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210076944A1 (en) 2019-09-18 2021-03-18 Massachusetts Institute Of Technology System and method for non-contact ultrasound image reconstruction

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2029767C (en) * 1990-11-13 1996-07-16 Najeeb Ashraf Khalid Laser scanning system for use in laser imaging
ATE333828T1 (en) * 2001-01-11 2006-08-15 Univ Johns Hopkins DETECTION OF THE TOOTH STRUCTURE USING LASER EXCITED ULTRASOUND
US20090287427A1 (en) * 2008-05-16 2009-11-19 Lockheed Martin Corporation Vision system and method for mapping of ultrasonic data into cad space
US8899115B2 (en) * 2011-04-20 2014-12-02 United Technologies Corporation Method and system for locating a laser vibrometer during non-contact scanning
US8843190B2 (en) * 2011-07-21 2014-09-23 The Board Of Trustees Of The Leland Stanford Junior University Medical screening and diagnostics based on air-coupled photoacoustics
FI124387B (en) * 2011-11-01 2014-08-15 Oscare Medical Oy Skeleton method and arrangement utilizing electromagnetic waves
WO2013112626A1 (en) * 2012-01-23 2013-08-01 Tomowave Laboratories, Inc. Laser optoacoustic ultrasonic imaging system (louis) and methods of use
WO2015077088A1 (en) * 2013-11-22 2015-05-28 Massachusetts Institute Of Technology System and method for non-contact ultrasound

Also Published As

Publication number Publication date
US20170265751A1 (en) 2017-09-21
WO2017209830A3 (en) 2019-04-04

Similar Documents

Publication Publication Date Title
Ambroziński et al. Acoustic micro-tapping for non-contact 4D imaging of tissue elasticity
US9131851B2 (en) Biological information imaging apparatus and method for analyzing biological information
US5840023A (en) Optoacoustic imaging for medical diagnosis
EP2510382B1 (en) Image generating apparatus, image generating method, and program
US9741111B2 (en) Subject information acquiring device and subject information acquiring method
US20060184042A1 (en) Method, system and apparatus for dark-field reflection-mode photoacoustic tomography
JP5751769B2 (en) Image information acquisition apparatus and control method thereof
EP2853917B1 (en) Photoacoustic and ultrasound echo imaging apparatus and method for controlling same
EP2482713B1 (en) Photoacoustic measuring apparatus
US7774042B2 (en) Tissue scanner
US20130336088A1 (en) Object information acquiring apparatus and control method thereof
JP2016537136A (en) System and method for non-contact ultrasound
CN110455719A (en) Three-dimensional photoacoustic imaging system and method
JP2012217717A (en) Subject information obtaining apparatus and subject information obtaining method
US20170258332A1 (en) System and method for non-contact ultrasound with enhanced safety
CN102740776A (en) Photoacoustic imaging apparatus and photoacoustic imaging method
US10641739B2 (en) Method and system for oblique backscattering ultrasound transmissive contrast imaging
JP2011183149A (en) Measuring device
JP2017164198A (en) Information processing system and display control method
JP2019165836A (en) Subject information acquisition device, and control method therefor
WO2016051749A1 (en) Object information acquiring apparatus
US20170265751A1 (en) Non-contact laser ultrasound system
US20200275840A1 (en) Information-processing apparatus, method of processing information, and medium
JP6478624B2 (en) Photoacoustic device
KR20170039784A (en) Optical coherence tomography device for the skin diagnostic

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 17807151

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 17807151

Country of ref document: EP

Kind code of ref document: A2