WO2017000837A1 - Oral care compositions and methods of use - Google Patents
Oral care compositions and methods of use Download PDFInfo
- Publication number
- WO2017000837A1 WO2017000837A1 PCT/CN2016/086995 CN2016086995W WO2017000837A1 WO 2017000837 A1 WO2017000837 A1 WO 2017000837A1 CN 2016086995 W CN2016086995 W CN 2016086995W WO 2017000837 A1 WO2017000837 A1 WO 2017000837A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- oral care
- care composition
- composition
- arginine
- amount
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Abstract
Description
Claims (21)
- An oral care composition comprising:a. a basic amino acid in free or salt wherein the amino acid is selected from arginine, lysine, and combinations thereof ;b. zinc oxide and zinc citratec. a fluoride sourced. glycerin.
- The oral care composition of claim 1, wherein the basic amino acid is arginine and wherein the arginine has the L-configuration.
- The oral care composition of claims 1 or 2, wherein the amino acid is arginine and wherein the arginine is present in an amount corresponding to 1% to 15%, the weight of the basic amino acid being calculated as free form.
- The oral care composition of any of the preceding claims wherein the amino acid is arginine from about 1.5 wt. %.
- The oral care composition of any of the preceding claims wherein the amino acid is arginine in free form.
- The oral care composition of any of the preceding claims wherein the amino acid is arginine or lysine in partially or wholly salt form.
- The oral care composition of any of the preceding claims, wherein the ratio of the amount of zinc oxide (by wt%) to zinc citrate (by wt%) is 2: 1, 2.5: 1, 3: 1, 3.5: 1 or 4: 1, wherein the ratio is by wt. of the overall composition.
- The oral care composition of claim 7, wherein the ratio of the amount of zinc oxide (by wt%) to zinc citrate (by wt%) is 2: 1.
- The oral care composition of any of the preceding claims, wherein the zinc citrate is in an amount of from 0.25 to 1.0 wt% and zinc oxide may be present in an amount of from 0.75 to 1.25 wt% based on the weight of the oral care composition.
- The oral care composition of any of the preceding claims, wherein the zinc citrate is in an amount of about 0.5 wt% and zinc is present in an amount of about 1.0% based on the weight of the oral care composition.
- The oral care composition of any of the preceding claims, wherein the fluoride source is sodium fluoride.
- The oral care composition of any of the preceding claims, wherein the glycerin is in an amount from 25% -40% based on the weight of the oral care composition.
- The oral care composition of claim 12, wherein the glycerin is in an amount of about 35% by wt.
- The oral care composition of claim 12, wherein the glycerin is in an amount of about 26% by wt.
- The oral care composition of any of the preceding claims, wherein the composition further comprises sorbitol.
- The composition of claim 15, wherein the sorbitol is in an amount of about 13% by wt. and the glycerin is in an amount of about 26% by wt.
- The oral care composition of any of claims 1-14 comprising:a. about 1.0% zinc oxideb. about 0.5% zinc citratec. about 1.5% L-arginined. about 0.32% sodium fluoride; ande. about 35% glycerin.
- The oral care composition of any of claims 1-16 comprising:a. about 1.0% zinc oxideb. about 0.5% zinc citratec. about 5% L-arginined. about 0.32% sodium fluoride;e. about 26% glycerin; andf. about 13% sorbitol.
- The oral care composition of any of the preceding claims, selected from the group consisting of: a toothpaste or a dentifrice, a mouthwash or a mouth rinse, a topical oral gel, and a denture cleanser.
- The oral care composition of any of the preceding claims, wherein the composition is obtained or obtainable by combining the ingredients as set forth in any of the preceding compositions.
- Use of an oral care composition of any one of the preceding claims in the manufacture of a medicament for application to the oral cavity of a subject in need thereof for improving oral health and, or to:i. reduce or inhibit formation of dental caries,ii. reduce, repair or inhibit early enamel lesions, e.g., as detected by quantitative light-induced fluorescence (QLF) or electrical caries measurement (ECM) ,iii. reduce or inhibit demineralization and promote remineralization of the teeth,iv. reduce hypersensitivity of the teeth,v. reduce or inhibit gingivitis,vi. promote healing of sores or cuts in the mouth,vii. reduce levels of acid producing bacteria,viii. to increase relative levels of arginolytic bacteria,ix. inhibit microbial bio film formation in the oral cavity,x. raise and/or maintain plaque pH at levels of at least pH 5.5 following sugar challenge,xi. reduce plaque accumulation,xii. treat dry mouth,xiii. enhance systemic health, including cardiovascular health,xiv. whiten teeth,xv. reduce erosion of the teeth,xvi. immunize (or protect) the teeth against cariogenic bacteria and their effects, and/orxvii. clean the teeth and oral cavity.
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR112017017202-0A BR112017017202B1 (en) | 2015-07-01 | 2016-06-24 | COMPOSITION FOR ORAL HYGIENE AND USE THEREOF |
CN201680009098.4A CN107205895B (en) | 2015-07-01 | 2016-06-24 | Oral care compositions and methods of use |
EP16817201.3A EP3247324B1 (en) | 2015-07-01 | 2016-06-24 | Oral care compositions and methods of use |
CA2976123A CA2976123A1 (en) | 2015-07-01 | 2016-06-24 | Oral care compositions and methods of use |
AU2016286006A AU2016286006B2 (en) | 2015-07-01 | 2016-06-24 | Oral care compositions and methods of use |
US15/548,468 US20180015016A1 (en) | 2015-07-01 | 2016-06-24 | Oral Care Compositions and Methods of Use |
RU2017128410A RU2017128410A (en) | 2015-07-01 | 2016-06-24 | COMPOSITIONS FOR CARE OF THE ORAL CAVITY AND METHODS OF USE |
MX2017010272A MX2017010272A (en) | 2015-07-01 | 2016-06-24 | Oral care compositions and methods of use. |
IL253526A IL253526B (en) | 2015-07-01 | 2017-07-17 | Oral care compositions and methods of use |
PH12017501321A PH12017501321A1 (en) | 2015-07-01 | 2017-07-20 | Oral care compositions and methods of use |
ZA2017/04985A ZA201704985B (en) | 2015-07-01 | 2017-07-21 | Oral care compositions and methods of use |
CONC2017/0008085A CO2017008085A2 (en) | 2015-07-01 | 2017-08-10 | Oral care compositions and methods of use |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562187801P | 2015-07-01 | 2015-07-01 | |
US62/187,801 | 2015-07-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2017000837A1 true WO2017000837A1 (en) | 2017-01-05 |
Family
ID=56297163
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2016/039226 WO2017003856A1 (en) | 2015-07-01 | 2016-06-24 | Oral care compositions and methods of use |
PCT/CN2016/086995 WO2017000837A1 (en) | 2015-07-01 | 2016-06-24 | Oral care compositions and methods of use |
PCT/US2016/039194 WO2017003844A1 (en) | 2015-07-01 | 2016-06-24 | Oral care compositions and methods of use |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2016/039226 WO2017003856A1 (en) | 2015-07-01 | 2016-06-24 | Oral care compositions and methods of use |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2016/039194 WO2017003844A1 (en) | 2015-07-01 | 2016-06-24 | Oral care compositions and methods of use |
Country Status (14)
Country | Link |
---|---|
US (5) | US20180015016A1 (en) |
EP (3) | EP3242652B1 (en) |
CN (5) | CN113456510A (en) |
AU (5) | AU2016285687B2 (en) |
BR (3) | BR112017017202B1 (en) |
CA (3) | CA2976123A1 (en) |
CO (3) | CO2017008079A2 (en) |
IL (3) | IL253515B (en) |
MX (4) | MX2017010003A (en) |
MY (3) | MY174712A (en) |
PH (3) | PH12017501310A1 (en) |
RU (3) | RU2700700C2 (en) |
WO (3) | WO2017003856A1 (en) |
ZA (3) | ZA201704984B (en) |
Cited By (11)
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US10058493B2 (en) | 2016-12-21 | 2018-08-28 | Colgate-Palmolive Company | Oral care compositions and methods of use |
WO2018157367A1 (en) * | 2017-03-03 | 2018-09-07 | The Procter & Gamble Company | Methods to quantify ion in dental biofilm |
WO2019117887A1 (en) * | 2017-12-13 | 2019-06-20 | Colgate-Palmolive Company | Dentifrice comprising zinc - amino acid complex |
WO2020016713A1 (en) * | 2018-07-16 | 2020-01-23 | 3M Innovative Properties Company | Amino acid containing oral care composition for treating caries by reducing lactic acid release in oral biofilms |
WO2020086298A1 (en) * | 2018-10-24 | 2020-04-30 | Colgate-Palmolive Company | Zinc - amino acid – lauryl sulfate complex with antimicrobial activity |
WO2021116873A1 (en) | 2019-12-12 | 2021-06-17 | 3M Innovative Properties Company | Oral care composition with n-acetyl amino acid components for treating caries |
US20210196588A1 (en) * | 2019-12-20 | 2021-07-01 | Colgate-Palmolive Company | Oral Care Compositions and Methods of Use |
EP3848017A1 (en) | 2020-01-08 | 2021-07-14 | 3M Innovative Properties Company | Oral care composition containing indole components for treating caries |
WO2021140437A1 (en) | 2020-01-08 | 2021-07-15 | 3M Innovative Properties Company | Anionic alkyl sulphate component for treating caries |
WO2022184115A1 (en) * | 2021-03-05 | 2022-09-09 | Colgate-Palmolive Company | Oral care compositions and methods of use |
AU2019406510B2 (en) * | 2018-12-20 | 2022-09-15 | Colgate-Palmolive Company | Oral care composition comprising zinc and an amino acid for treating symptoms of a gastric disorder in the oral cavity |
Families Citing this family (23)
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CN104721063B (en) | 2013-12-19 | 2018-05-08 | 高露洁-棕榄公司 | Dentrifice composition comprising zinc oxide and zinc citrate |
CN107106426B (en) | 2014-12-26 | 2021-01-15 | 高露洁-棕榄公司 | Low moisture dentifrice compositions |
MX2020004498A (en) | 2016-06-24 | 2022-06-09 | Colgate Palmolive Co | Oral care compositions and methods of use. |
WO2018118161A1 (en) | 2016-12-21 | 2018-06-28 | Colgate-Palmolive Company | Oral care compositions and methods of use |
JP7058342B2 (en) * | 2018-03-29 | 2022-04-21 | ザ プロクター アンド ギャンブル カンパニー | Oral care composition to promote gingival health |
US11675053B2 (en) | 2018-06-15 | 2023-06-13 | Innovusion, Inc. | LiDAR systems and methods for focusing on ranges of interest |
BR112021011600A2 (en) | 2018-12-26 | 2021-08-31 | Colgate-Palmolive Company | METHODS OF SWITCHING BIOFILM IN THE ORAL CAVITY FROM PATHOGENIC TO HEALTHY BIOFILM |
US20200206108A1 (en) * | 2018-12-26 | 2020-07-02 | Colgate-Palmolive Company | Oral Care Compositions and Methods of Use |
US20210196598A1 (en) | 2018-12-26 | 2021-07-01 | Colgate-Palmolive Company | Specific Co-Aggregation Inhibition by Arginine |
WO2020139624A1 (en) | 2018-12-26 | 2020-07-02 | Colgate-Palmolive Company | Methods of inhibiting neutrophil recruitment to the gingival crevice |
CN113271918A (en) | 2018-12-26 | 2021-08-17 | 高露洁-棕榄公司 | Reduction of pathogenic bacteria using arginine |
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AU2020304368B2 (en) * | 2019-06-28 | 2023-09-07 | Colgate-Palmolive Company | Oral care compositions and methods of use |
WO2021062607A1 (en) * | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Oral care compositions comprising hops beta acid and amino acid |
WO2021067992A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Methods of use of oral care compositions comprising hops |
WO2021137154A1 (en) * | 2019-12-31 | 2021-07-08 | 3M Innovative Properties Company | Aqueous zinc oral care compositions with fluoride |
WO2021175577A1 (en) | 2020-03-03 | 2021-09-10 | Unilever Ip Holdings B.V. | Transparent dentifrice comprising zinc |
CN115297933A (en) * | 2020-03-24 | 2022-11-04 | 高露洁-棕榄公司 | Improved process for making arginine dentifrices |
US11931443B2 (en) | 2020-03-27 | 2024-03-19 | Colgate-Palmolive Company | Oral care compositions and methods of use |
US20210308028A1 (en) | 2020-03-30 | 2021-10-07 | Colgate-Palmolive Company | Compositions and Methods for Maintaining and Protecting Tissue Integrity and Barrier Function |
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