WO2016177771A1 - Single-chain cd40-receptor agonist proteins - Google Patents
Single-chain cd40-receptor agonist proteins Download PDFInfo
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- WO2016177771A1 WO2016177771A1 PCT/EP2016/059983 EP2016059983W WO2016177771A1 WO 2016177771 A1 WO2016177771 A1 WO 2016177771A1 EP 2016059983 W EP2016059983 W EP 2016059983W WO 2016177771 A1 WO2016177771 A1 WO 2016177771A1
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- Prior art keywords
- receptor agonist
- protein
- cd40l
- seq
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/22—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153 or CD154
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- Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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Abstract
Description
Claims
Priority Applications (12)
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EP16725774.0A EP3292143B1 (en) | 2015-05-04 | 2016-05-04 | Single-chain cd40-receptor agonist proteins |
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RU2017141727A RU2745801C2 (en) | 2015-05-04 | 2016-05-04 | Single-stranded cd40 receptor agonist proteins |
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AU2016257000A AU2016257000B2 (en) | 2015-05-04 | 2016-05-04 | Single-chain CD40-receptor agonist proteins |
US15/795,020 US10793616B2 (en) | 2015-05-04 | 2017-10-26 | Single-chain CD40-receptor agonist proteins |
US17/063,018 US20210032309A1 (en) | 2015-05-04 | 2020-10-05 | Single-chain cd40-receptor agonist proteins |
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US (2) | US10793616B2 (en) |
EP (1) | EP3292143B1 (en) |
JP (1) | JP6738831B2 (en) |
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CN (1) | CN107709355B (en) |
AU (1) | AU2016257000B2 (en) |
BR (1) | BR112017023646A2 (en) |
CA (1) | CA2984350A1 (en) |
ES (1) | ES2754432T3 (en) |
MX (1) | MX2017014140A (en) |
RU (1) | RU2745801C2 (en) |
WO (1) | WO2016177771A1 (en) |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019523636A (en) * | 2016-05-13 | 2019-08-29 | メディミューン,エルエルシー | CD40L-Fc fusion polypeptide and methods of use thereof |
CN110760541A (en) * | 2019-10-31 | 2020-02-07 | 中国农业科学院兰州兽医研究所 | Selection method and application of signal peptide when Chinese hamster ovary cells express foreign proteins |
WO2020065409A3 (en) * | 2018-09-28 | 2020-05-07 | Lyvgen Biopharma Co., Ltd. | Anti-cd40 binding molecules having engineered fc domains and therapeutic uses thereof |
US20200157169A1 (en) * | 2018-06-29 | 2020-05-21 | Akston Biosciences Corporation | Ultra-long acting insulin-fc fusion proteins and methods of use |
WO2020193718A1 (en) * | 2019-03-27 | 2020-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Recombinant proteins with cd40 activating properties |
WO2020207470A1 (en) | 2019-04-10 | 2020-10-15 | 南开大学 | Anti-cd40 antibody and use thereof |
WO2021229103A2 (en) | 2020-05-15 | 2021-11-18 | Apogenix Ag | Multi-specific immune modulators |
US11186623B2 (en) | 2019-12-24 | 2021-11-30 | Akston Bioscience Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
US11186648B2 (en) | 2018-09-28 | 2021-11-30 | Lyvgen Biopharma Co., Ltd. | Anti-CD40 antibody having engineered Fc domains and therapeutic uses thereof |
US11192930B2 (en) | 2020-04-10 | 2021-12-07 | Askton Bioscences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
US11198719B2 (en) | 2020-04-29 | 2021-12-14 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
US11213581B2 (en) | 2020-04-10 | 2022-01-04 | Akston Biosciences Corporation | Antigen specific immunotherapy for COVID-19 fusion proteins and methods of use |
US11267862B2 (en) | 2018-06-29 | 2022-03-08 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
US11352407B2 (en) | 2019-12-19 | 2022-06-07 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion proteins |
US11359001B2 (en) | 2016-12-09 | 2022-06-14 | Akston Biosciences Corporation | Insulin-Fc fusions and methods of use |
WO2023088876A1 (en) | 2021-11-16 | 2023-05-25 | Apogenix Ag | Multi-specific immune modulators |
US11667689B2 (en) | 2021-07-23 | 2023-06-06 | Akston Biosciences Corporation | Insulin-Fc fusion proteins and methods of use to treat cancer |
US11976123B2 (en) | 2018-04-20 | 2024-05-07 | Lyvgen Biopharma Holdings Limited | Anti-CD40 antibodies and uses thereof |
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- 2016-05-04 RU RU2017141727A patent/RU2745801C2/en active
- 2016-05-04 WO PCT/EP2016/059983 patent/WO2016177771A1/en active Application Filing
- 2016-05-04 CA CA2984350A patent/CA2984350A1/en active Pending
- 2016-05-04 MX MX2017014140A patent/MX2017014140A/en unknown
- 2016-05-04 AU AU2016257000A patent/AU2016257000B2/en active Active
- 2016-05-04 JP JP2017555643A patent/JP6738831B2/en active Active
- 2016-05-04 EP EP16725774.0A patent/EP3292143B1/en active Active
- 2016-05-04 BR BR112017023646A patent/BR112017023646A2/en not_active IP Right Cessation
- 2016-05-04 CN CN201680032719.0A patent/CN107709355B/en active Active
- 2016-05-04 KR KR1020177035006A patent/KR20170138585A/en not_active Application Discontinuation
- 2016-05-04 ES ES16725774T patent/ES2754432T3/en active Active
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2017
- 2017-10-26 US US15/795,020 patent/US10793616B2/en active Active
-
2020
- 2020-10-05 US US17/063,018 patent/US20210032309A1/en not_active Abandoned
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EP3455263A4 (en) * | 2016-05-13 | 2020-01-01 | MedImmune, LLC | Cd40l-fc fusion polypeptides and methods of use thereof |
JP2019523636A (en) * | 2016-05-13 | 2019-08-29 | メディミューン,エルエルシー | CD40L-Fc fusion polypeptide and methods of use thereof |
US11359001B2 (en) | 2016-12-09 | 2022-06-14 | Akston Biosciences Corporation | Insulin-Fc fusions and methods of use |
US11976123B2 (en) | 2018-04-20 | 2024-05-07 | Lyvgen Biopharma Holdings Limited | Anti-CD40 antibodies and uses thereof |
US11267862B2 (en) | 2018-06-29 | 2022-03-08 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
US11673934B2 (en) | 2018-06-29 | 2023-06-13 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
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US10851147B2 (en) * | 2018-06-29 | 2020-12-01 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
US10870686B2 (en) * | 2018-06-29 | 2020-12-22 | Akston Biosciences Corporation | Ultra-long acting insulin-FC fusion proteins and methods of use |
US20200157169A1 (en) * | 2018-06-29 | 2020-05-21 | Akston Biosciences Corporation | Ultra-long acting insulin-fc fusion proteins and methods of use |
US11261229B2 (en) | 2018-06-29 | 2022-03-01 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
US11186648B2 (en) | 2018-09-28 | 2021-11-30 | Lyvgen Biopharma Co., Ltd. | Anti-CD40 antibody having engineered Fc domains and therapeutic uses thereof |
WO2020065409A3 (en) * | 2018-09-28 | 2020-05-07 | Lyvgen Biopharma Co., Ltd. | Anti-cd40 binding molecules having engineered fc domains and therapeutic uses thereof |
WO2020193718A1 (en) * | 2019-03-27 | 2020-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Recombinant proteins with cd40 activating properties |
WO2020207470A1 (en) | 2019-04-10 | 2020-10-15 | 南开大学 | Anti-cd40 antibody and use thereof |
CN110760541B (en) * | 2019-10-31 | 2022-03-29 | 中国农业科学院兰州兽医研究所 | Selection method and application of signal peptide when Chinese hamster ovary cells express foreign proteins |
CN110760541A (en) * | 2019-10-31 | 2020-02-07 | 中国农业科学院兰州兽医研究所 | Selection method and application of signal peptide when Chinese hamster ovary cells express foreign proteins |
US11352407B2 (en) | 2019-12-19 | 2022-06-07 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion proteins |
US11555058B2 (en) | 2019-12-19 | 2023-01-17 | Akston Biosciences Corporation | Cells engineered to express ultra-long acting insulin-Fc fusion proteins |
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US11186623B2 (en) | 2019-12-24 | 2021-11-30 | Akston Bioscience Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
US11213581B2 (en) | 2020-04-10 | 2022-01-04 | Akston Biosciences Corporation | Antigen specific immunotherapy for COVID-19 fusion proteins and methods of use |
US11707517B2 (en) | 2020-04-10 | 2023-07-25 | Akston Biosciences Corporation | Antigen specific immunotherapy for COVID-19 fusion proteins and methods of use |
US11814418B2 (en) | 2020-04-10 | 2023-11-14 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
US11192930B2 (en) | 2020-04-10 | 2021-12-07 | Askton Bioscences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
US11198719B2 (en) | 2020-04-29 | 2021-12-14 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
WO2021229103A2 (en) | 2020-05-15 | 2021-11-18 | Apogenix Ag | Multi-specific immune modulators |
US11667689B2 (en) | 2021-07-23 | 2023-06-06 | Akston Biosciences Corporation | Insulin-Fc fusion proteins and methods of use to treat cancer |
WO2023088876A1 (en) | 2021-11-16 | 2023-05-25 | Apogenix Ag | Multi-specific immune modulators |
Also Published As
Publication number | Publication date |
---|---|
EP3292143B1 (en) | 2019-08-21 |
US20180066036A1 (en) | 2018-03-08 |
JP6738831B2 (en) | 2020-08-12 |
CN107709355B (en) | 2021-09-14 |
AU2016257000A1 (en) | 2017-11-23 |
RU2017141727A3 (en) | 2019-11-05 |
MX2017014140A (en) | 2018-03-15 |
WO2016177771A9 (en) | 2017-06-29 |
AU2016257000B2 (en) | 2020-05-14 |
CA2984350A1 (en) | 2016-11-10 |
ES2754432T3 (en) | 2020-04-17 |
JP2018515072A (en) | 2018-06-14 |
EP3292143A1 (en) | 2018-03-14 |
RU2745801C2 (en) | 2021-04-01 |
BR112017023646A2 (en) | 2018-07-17 |
US10793616B2 (en) | 2020-10-06 |
CN107709355A (en) | 2018-02-16 |
KR20170138585A (en) | 2017-12-15 |
US20210032309A1 (en) | 2021-02-04 |
RU2017141727A (en) | 2019-06-04 |
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