WO2016142049A1 - Amatoxin-antibody conjugates - Google Patents

Amatoxin-antibody conjugates Download PDF

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Publication number
WO2016142049A1
WO2016142049A1 PCT/EP2016/000397 EP2016000397W WO2016142049A1 WO 2016142049 A1 WO2016142049 A1 WO 2016142049A1 EP 2016000397 W EP2016000397 W EP 2016000397W WO 2016142049 A1 WO2016142049 A1 WO 2016142049A1
Authority
WO
WIPO (PCT)
Prior art keywords
antibody
heavy chain
group
thiol
linker
Prior art date
Application number
PCT/EP2016/000397
Other languages
French (fr)
Inventor
Jan Anderl
Torsten HECHLER
Christoph Mueller
Andreas Pahl
Original Assignee
Heidelberg Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP15000681.5 priority Critical
Priority to EP15000681 priority
Application filed by Heidelberg Pharma Gmbh filed Critical Heidelberg Pharma Gmbh
Publication of WO2016142049A1 publication Critical patent/WO2016142049A1/en

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