WO2016052108A1 - Molded-article production device and molded-article production method - Google Patents

Molded-article production device and molded-article production method Download PDF

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Publication number
WO2016052108A1
WO2016052108A1 PCT/JP2015/075552 JP2015075552W WO2016052108A1 WO 2016052108 A1 WO2016052108 A1 WO 2016052108A1 JP 2015075552 W JP2015075552 W JP 2015075552W WO 2016052108 A1 WO2016052108 A1 WO 2016052108A1
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WO
WIPO (PCT)
Prior art keywords
blade
raw material
material liquid
mold
drying
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PCT/JP2015/075552
Other languages
French (fr)
Japanese (ja)
Inventor
山田 真也
長信 赤尾
大煥 智山
梨沙 中岡
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日本写真印刷株式会社
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Application filed by 日本写真印刷株式会社 filed Critical 日本写真印刷株式会社
Publication of WO2016052108A1 publication Critical patent/WO2016052108A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Definitions

  • the present invention relates to a manufacturing apparatus and a manufacturing method of a molded body having a plurality of convex portions, and particularly relates to a manufacturing apparatus and a manufacturing method for manufacturing a molded body having a plurality of convex portions in a sanitary manner.
  • Patent Document 1 discloses a technique of filling a plurality of concave portions of a stamper, which is a mold of a molded body, with a raw material using a squeegee. In the technique disclosed in Patent Document 1, the liquid raw material filled in the plurality of recesses is solidified to form a plurality of projections on the surface of the molded body.
  • An object of the present invention is to provide a manufacturing apparatus and a manufacturing method of a molded body that can easily ensure a sanitary state in manufacturing a molded body having a plurality of convex portions.
  • the manufacturing apparatus of the molded object which concerns on one aspect of this invention supplies the 1st raw material liquid for shape
  • the blade supply mechanism is configured so that the plurality of recesses are filled with the first raw material liquid by the first supply device, the blade gripping mechanism that detachably holds the blade, and the blade held by the blade holding mechanism.
  • the first raw material liquid adheres from the blade holding mechanism before the blade holding mechanism is moved by the moving mechanism and the plurality of recesses are filled with the first raw material liquid.
  • a blade exchanging mechanism for removing the blade and attaching the blade to which the first raw material liquid is not attached to the blade gripping mechanism is provided.
  • the blade gripping mechanism includes the first gripper before the operation in which the blade gripping mechanism is moved by the moving mechanism to fill the plurality of concave portions of the mold with the first raw material liquid. Instead of the blade with the first raw material liquid attached, a blade without the first raw material liquid attached is attached. As a result, it is possible to manufacture such that the first raw material liquid is filled in the concave portion of the mold by always using a sanitary blade to which the first raw material liquid is not attached.
  • the blade replacement mechanism may be configured to include a blade stocker that stocks a plurality of blades, and an attachment mechanism that transports and attaches the blades from the blade stocker to the blade gripping mechanism.
  • a sanitary blade to which the first raw material liquid is not attached is automatically conveyed from the blade stocker to the blade gripping mechanism by the mounting mechanism, and is automatically attached to the blade gripping mechanism.
  • the sanitary aspect can be improved by omitting the worker who performs the work for attaching the blade.
  • the blade replacement mechanism may be configured to further include a removal mechanism for removing the blade to which the first raw material liquid has adhered from the blade gripping mechanism.
  • the blade to which the first raw material liquid is attached can be automatically removed by the removal mechanism, and the hygiene can be improved by omitting the worker who performs the work for removing the blade.
  • the manufacturing apparatus may be configured to further include a second supply device. In the manufacturing apparatus configured as described above, since the second raw material liquid different from the first raw material liquid can be supplied by the second supply device, the molded body having a different composition that forms the convex portion depending on the location in the convex portion. Easy to manufacture.
  • the manufacturing method of the molded object which concerns on one aspect of this invention supplies the 1st raw material liquid for shape
  • a first supply step a filling step in which the blade held by the blade holding mechanism is relatively moved along the surface of the mold, and the plurality of concave portions of the mold are filled with the first raw material liquid by the blade; Before the filling step, the blade is attached to the blade gripping mechanism by removing the blade to which the first raw material liquid adheres, and the blade replacement step for attaching the blade to which the first raw material liquid is not attached to the blade gripping mechanism.
  • the blade gripping mechanism is moved by the blade replacement step before the operation of filling the plurality of concave portions of the mold with the first raw material liquid in the filling step.
  • a blade to which the first raw material liquid is not attached is attached to the mechanism in place of the blade to which the first raw material liquid is attached.
  • a drying process for drying the first raw material liquid filled in the plurality of concave portions of the mold and a second raw material liquid is supplied to the surface of the mold where the first raw material liquid in the plurality of concave sections is dried in the drying process.
  • the manufacturing method may be configured to further include a second supplying step. In the manufacturing method configured as described above, since the second raw material liquid different from the first raw material liquid can be supplied in the second supply step, the composition forming the convex portion differs depending on the location in the convex portion. Easy to manufacture.
  • the molded body manufacturing apparatus or the molded body manufacturing method according to the present invention has an effect that it is easy to ensure a sanitary state in manufacturing a molded body having a plurality of convex portions.
  • the schematic diagram which shows an example of the manufacturing apparatus of the molded object which concerns on one Embodiment of this invention.
  • the perspective view which shows an example of the molded object manufactured with the manufacturing apparatus of FIG.
  • the partial expansion perspective view which expanded a part of the molded object shown by FIG.
  • the flowchart for demonstrating the manufacturing process of the molded object which concerns on one Embodiment.
  • the perspective view for demonstrating the specific example of a filling part.
  • A) A schematic cross-sectional view for explaining the second supply step (b) a schematic cross-sectional view for explaining the substrate assembly step, and (c) a step of drying with the second drying magazine.
  • the molded body manufactured by the molded body manufacturing apparatus 10 of FIG. 1 is, for example, a molded body containing a drug for a transdermal patch used for drug administration.
  • the molded body 100 described in this embodiment includes a cone-shaped protrusion 103 in which two different types of layers are stacked on a surface 102 of a plate-like substrate 101. Has a shape in which a plurality of are formed.
  • the substrate 101 is a member having good air permeability, for example, a porous member.
  • the cone-shaped protrusion 103 differs in composition and / or property between the tip portion 104 and the base portion 105.
  • the manufacturing apparatus 10 has a function of applying two types of raw material liquids.
  • a laminated film 106 having the same composition as the base portion 105 is formed on the surface 102 of the substrate 101.
  • the molded body manufacturing apparatus 10 includes an isolator 11 that keeps an internal working space in a sterile state, and an isolator front chamber 12 and an isolator rear chamber 13 that are provided before and after the isolator 11.
  • the isolator 11 can maintain the atmosphere of the work space 11a aseptically at a temperature of 25 ° C. and a humidity of 70%.
  • the isolator front chamber 12 and the isolator rear chamber 13 are decontamination pass boxes that communicate with the isolator 11 from the outside, for example, and have a function of sterilizing the internal spaces 12a and 13a.
  • Isolator front chamber 12 The isolator front chamber 12 is configured to be openable to the outside, and a front chamber magazine 14 that can store a plurality of molds 80 can be mounted in the open internal space 12a of the isolator front chamber 12.
  • the plurality of molds 80 housed in the isolator front chamber 12 are sterilized together with the front chamber magazine 14 with the internal space 12a of the isolator front chamber 12 sealed against the outside and the isolator 11.
  • the passage 12b connected from the isolator front chamber 12 to the isolator 11 is blocked.
  • the mold 80 accommodated in the front chamber magazine 14 mounted in the isolator front chamber 12 can be moved to the mold supply magazine 20 in the work space 11 a of the isolator 11.
  • the front chamber magazine 14 moves from the isolator front chamber 12 to the isolator 11
  • the isolator front chamber 12 is blocked from the external space, and the passage 12 b between the isolator front chamber 12 and the isolator 11 communicates.
  • the isolator 11 includes belt conveyors 21 and 27, a first dispenser 22, a filling unit 23, a first drying magazine 24, a second dispenser 25, a substrate, as well as the above-described mold supply magazine 20.
  • a pressure mounting device 26 and a second drying magazine 28 are provided.
  • the mold 80 moved to the mold supply magazine 20 of the isolator 11 is placed on the belt conveyor 21 by a loader (not shown).
  • the belt conveyor 21 conveys the mold 80 to the first dispenser 22 to the dispensing position P1 (see FIG. 5) and automatically stops.
  • the first dispenser 22 discharges a predetermined amount of the first raw material liquid 91 containing a chemical substance to be introduced into the human body onto the surface of the mold 80 (see FIG. 6A).
  • the mold 80 coated with the first raw material liquid 91 is automatically conveyed to the filling unit 23 by the belt conveyor 21.
  • the first raw material liquid 91 is sufficiently filled into the concave portion of the mold 80 by the blade 31 (see FIGS. 6B and 6C).
  • the first raw material liquid 91 hardly remains on the surface of the mold 80.
  • the mold 80 in which the concave portion is filled with the first raw material liquid 91 is automatically transported to the vicinity of the first drying magazine 24 by the belt conveyor 21 and, for example, the first drying magazine by an unloader (not shown). 24. Then, the first stock in the first drying magazine 24 is sequentially taken out, and is automatically placed on the next second dispenser 25 by, for example, a loader (not shown). While being stocked in the first drying magazine 24, the first raw material liquid 91 filled in the recesses of the mold 80 is dried. As can be seen from a comparison between FIG. 6C and FIG. 7A, the volume of the first raw material liquid 91 decreases when it is dried.
  • the second dispenser 25 discharges a predetermined amount of a second raw material liquid 92 containing a chemical substance to be introduced into the human body onto the surface of the mold 80 (see FIG. 7A).
  • the mold 80 to which the second raw material liquid 92 is applied is automatically conveyed from the second dispenser 25 to the substrate pressure mounting apparatus 26 by, for example, the belt conveyor 27.
  • the substrate pressing and mounting apparatus 26 the substrate 101 is pressed and brought into close contact with the second raw material liquid 92 before drying on the second raw material liquid 92 discharged onto the surface of the mold 80 by, for example, a robot arm (see FIG. (Refer FIG.7 (b)).
  • the mold 80 is automatically conveyed from the substrate pressure mounting device 26 to the vicinity of the second drying magazine 28 by the belt conveyor 27, and is secondly transferred by, for example, an unloader (not shown).
  • the second drying magazine 28 is disposed in the dry stock area 11 b of the isolator 11 that is isolated from the area up to the substrate pressure mounting device 26.
  • the dry stock area 11b is maintained at a higher temperature and lower humidity than the work space 11a of the isolator 11 in order to promote drying.
  • step S ⁇ b> 1 the mold 80 is set in the first dispenser 22 using the belt conveyor 27.
  • step S ⁇ b> 2 the first raw material liquid 91 is supplied to the mold 80 by the first dispenser 22.
  • step S3 includes the blade replacement step of step S3-1 and the step of filling the recess with the blade of step S3-2. These steps S3-1 and S3-2 will be described in detail later.
  • step S4 the mold 80 in which the concave portion is filled with the first raw material liquid 91 is dried in the first raw material liquid 91 while being stored in the first drying magazine 24.
  • step S ⁇ b> 5 the mold 80 from which the first raw material liquid 91 in the recess is dried is set in the second dispenser 25 by the belt conveyor 27.
  • step S ⁇ b> 6 the second raw material liquid 92 is supplied to the mold 80 by the second dispenser 25.
  • step S ⁇ b> 7 the substrate 101 is pressed onto the second raw material liquid 92.
  • step S ⁇ b> 8 the second raw material liquid 92 is dried while the mold 80 on which the second raw material liquid 92 is discharged onto the surface is stored in the second drying magazine 28.
  • Step S9 after drying is a process after the rear chamber magazine 15 is taken out from the isolator rear chamber 13, and the molded body formed in the mold 80 is punched and the molded body is packaged. Is called.
  • the isolator rear chamber 13 is configured to be openable to the outside, and the rear chamber magazine 15 can be taken out from the internal space 13 a of the opened isolator rear chamber 13.
  • the rear chamber magazine 15 can accommodate the mold 80 moved from the second drying magazine 28 in the drying stock area 11 b of the isolator 11 to the isolator rear chamber 13.
  • the passage 13 b connected from the isolator 11 to the isolator rear chamber 13 communicates, and the isolator rear chamber 13 is sealed off from the external space.
  • the passage 13b connected from the isolator rear chamber 13 to the isolator 11 is sealed. After the isolator rear chamber 13 is opened to the outside, sterilization is performed.
  • the rear chamber magazine 15 taken out from the isolator rear chamber 13 contains a molded body fitted in the mold 80.
  • the rear chamber magazine 15 in which the molded body is stored can be sealed in a hygienic state (for example, aseptic) and distributed as a product.
  • the molded body is removed from the mold 80, and the molded body is packaged in a sanitary state (for example, aseptic condition) or the molded body is assembled with other members. After that, it can be packaged in a sanitary state (for example, aseptic), and the molded product in the packaged state can be distributed as a product.
  • a sanitary state for example, aseptic condition
  • the machine is also operated in the clean room after the isolator rear chamber 13 or after the isolator rear chamber 13. The work is continued in a hygienic environment, such as by connecting another isolator to the subsequent stage.
  • the mold 80 may be formed of a sanitary material that is not exposed to the raw material liquid, but can be formed of, for example, plastic, ceramic, or metal.
  • the plastic forming the mold 80 include polyethylene or polypropylene, and examples of the metal forming the mold 80 include stainless steel.
  • a conical or pyramidal space having a circular, polygonal, and elliptical cross-sectional shape is formed.
  • the first raw material liquid 91 is obtained by dissolving solid raw materials in, for example, water, a mixed solution of water and alcohol, or another solvent.
  • Solid raw materials are polymer substances that are harmless to the human body, and include, for example, resins that are harmless to the human body, polysaccharides that are harmless to the human body, proteins that are harmless to the human body, and compounds derived therefrom that are harmless to the human body.
  • the first raw material liquid 91 is obtained by, for example, dissolving at least one of water-soluble polysaccharides, water-soluble proteins, polyvinyl alcohol, carboxyvinyl polymer, and sodium polyacrylate in water.
  • the water-soluble polysaccharide is sodium chondroitin sulfate
  • an example of the water-soluble protein is serum albumin.
  • the chemical substance to be introduced into the human body include biologically active substances used for the purpose of treatment, diagnosis and prevention of wounds. Examples of such biologically active substances include insulin and growth hormone.
  • the second raw material liquid 92 is different from the first raw material liquid 91 in at least one of the kind of chemical substance, the content of the chemical substance, the solid raw material, and the solvent.
  • the composition of the tip portion 104 and the base portion 105 differs depending on at least one of the kind of chemical substance, the content of the chemical substance, and the solid raw material. Also, for example, by changing the state after drying by changing the solvent and the drying method, for example, by making the solubility different, even if the tip portion 104 and the base portion 105 have the same composition, they have different properties. be able to.
  • the filling unit 23 includes a blade stocker 30, a plurality of blades 31 stocked in the blade stocker 30, an attachment mechanism 32, a blade gripping mechanism 33, a moving mechanism 34, a removal mechanism 35, and a collection box 36. Is installed.
  • the blade stocker 30 is a device for storing a plurality of blades 31 at a predetermined stock position P10.
  • the blade stocker 30 shown in FIG. 4 has guide frames 30a that come into contact with the four corners of a plurality of blades 31 that are horizontally stacked.
  • the blade 31 has a rectangular shape in plan view, and has a wedge-shaped cross section with a thickness decreasing toward one of the long sides. One side of the thinner side is the cutting edge of the blade 31.
  • the four guide frames 30a extend vertically upward.
  • the blades 31 are conveyed by the attachment mechanism 32 in order from the one mounted on the uppermost stage of the blade stocker 30. When the blades 31 are taken out from the blade stocker 30, the attachment mechanism 32 temporarily moves vertically upward along the guide frame 30a. Lifted.
  • the attachment mechanism 32 includes two suction cups 32a made of rubber, for example, hemispherical. These suction disks 32a are configured to be able to be sucked onto the upper surface of the blade 31 by making the inside vacuum. By the way, since the attachment mechanism 32 has a function of aligning the positions of the two suction disks 32a with the stock position P10, the suction disk 32a can always convey a predetermined portion of the upper surface of the blade 31 by vacuum suction.
  • the attachment mechanism 32 is moved vertically upward from the blade stocker 30 by a predetermined distance, and then moves the blade 31 in the horizontal direction to wait for a predetermined position at the slit 33a of the blade gripping mechanism 33 (see FIG. 6B). ).
  • the blade gripping mechanism 33 is, for example, a plastic rectangular parallelepiped rod-shaped member having elasticity.
  • the slit 33a of the blade gripping mechanism 33 crosses one surface of the rectangular parallelepiped along the longitudinal direction, and the depth from the one surface is constant. Therefore, when the blade 31 having a rectangular shape in plan view is brought into contact with the deepest portion of the slit 33a, the distance from the blade edge of the blade 31 to one surface of the blade gripping mechanism 33 crossed by the slit 33a is at an arbitrary position of the blade edge. It becomes constant. That is, the shape of the blade 31 protruding from the blade gripping mechanism 33 is also rectangular in plan view.
  • the blade gripping mechanism 33 uses, for example, a material that is easily elastically deformed even when the above-described rubber is not attached, and the blade gripping mechanism 33 is elastically deformed when the blade 31 is inserted into the slit 33a. By configuring so, the blade 31 can be sandwiched and held between the opposing surfaces of the slit 33a.
  • a force that a finger 34a of a robot arm, which is an example of a moving mechanism 34 described later, grips the blade gripping mechanism 33 may be used as an auxiliary force that the blade gripping mechanism 33 grips and holds the blade 31.
  • the moving mechanism 34 is composed of, for example, an articulated robot arm having a finger 34a for gripping the blade gripping mechanism 33 at the tip.
  • the moving mechanism 34 performs the following operations (a) to (d).
  • the blade gripping mechanism 33 is fixed with the surface facing.
  • B In cooperation with the attachment mechanism 32, the blade 31 is inserted into the slit 33a, and the blade 31 is pushed in until the blade 31 contacts the deepest portion of the slit 33a.
  • the blade 31 is moved horizontally along the surface 81 of the mold 80 while maintaining a predetermined angle ⁇ (see FIG. 7C) with respect to the surface of the mold 80.
  • This angle ⁇ is an acute angle.
  • the blade 31 moves while the vertical cross section cut along the traveling direction is inclined with respect to the traveling direction and contacts the first raw material liquid 91.
  • the first raw material liquid 91 is pushed and filled into the plurality of recesses 82 (see FIG. 6) by the blade 31.
  • the blade 31 is brought into contact with the surface 81 of the mold 80, but when it is desired to form a composition obtained by drying the first raw material liquid 91 on the surface 102 of the molded body 100, the blade 31 is moved to the surface of the mold 80. In some cases, the surface 81 is not contacted.
  • FIG. 5 it is described that the circle indicating the first raw material liquid 91 is simply expanded by the blade 31, but these circles are formed in a plurality of recesses in a region surrounded by the circle. The raw material liquid 91 is filled, and a state in which the first raw material liquid 91 does not remain on the surface around the recess is schematically shown.
  • the removal mechanism 35 includes two suction discs 35a made of rubber, for example, hemispherical. These suction plates 35a are configured to be able to be sucked onto the surface of the blade 31 by making the inside a vacuum state. By the way, the removal mechanism 35 has a function of aligning the positions of the two suction disks 32a with the blade 31 positioned directly above the collection box 36. The removal mechanism 35 vacuum-sucks the surface of the blade 31 with these suction plates 35a and pulls the blade 31 downward from the blade gripping mechanism 33 in cooperation with the moving mechanism 34. The removal mechanism 35 stops the suction by the suction disk 35 a and puts the extracted blade 31 into the collection box 36.
  • the first dispenser 22 is arranged in the front stage of the filling unit 23.
  • the belt conveyor 21 operates intermittently.
  • the mold 80 placed on the belt conveyor 21 from the mold supply magazine 20 (see FIG. 1) is transported during the next operation of the belt conveyor 21 and is stored in the first dispenser 22.
  • the first dispenser 22 discharges the surface of the die 80.
  • the mold 80 is configured such that four molded bodies 100 (see FIG. 2) can be molded at a time. Accordingly, by moving the head 22 a of the first dispenser 22, the first raw material liquid 91 is discharged to four locations on the surface of one mold 80.
  • the belt conveyor 21 is operated, and the mold 80 is carried from the dispensing position P1 to the filling position P2.
  • the blade 31 to which the first raw material liquid 91 is attached is removed by the removal mechanism 35, the new blade 31 is attached to the blade gripping mechanism 33 by the attachment mechanism 32, and the blade 31 is exchanged (step). S3-1).
  • the blade gripping mechanism 33 is moved along the mold 80 by the moving mechanism 34 to fill the first raw material liquid 91 (step S3-2).
  • the mold 80 filled with the first raw material liquid 91 is transported from the filling position P2 toward the first drying magazine 24 when the belt conveyor 21 is operated next time.
  • First drying magazine 24 and second drying magazine 28 The first drying magazine 24 is a drying device for drying the first raw material liquid 91 (see FIG. 6C) filled in the plurality of concave portions 82 of the mold 80. Further, the second drying magazine 28 uses the second raw material liquid 92 applied to the surface 81 of the mold 80 and the second raw material liquid 92 filled in the plurality of recesses 82 (see FIG. 7C). It is a drying device for drying. For example, 50 molds 80 can be stocked in the first drying magazine 24 and the second drying magazine 28. For example, the first raw material liquid 91 in the recess 82 is blown into a gap provided between the molds 80 by a fan (not shown) and stocked in the first drying magazine 24. The second raw material liquid 92 in the recess 82 is sufficiently dried during the period of being sufficiently dried and stocked in the second drying magazine 28.
  • Second dispenser 25 7A in the first drying magazine 24, the second raw material liquid 92 is applied to the surface 81 of the dried mold 80 of the first raw material liquid 91 in the plurality of recesses 82. As shown in FIG. Is discharged. For example, the second raw material liquid 92 is discharged toward the center of the region where the plurality of recesses 82 are formed. The discharged second raw material liquid 92 spreads on the surface 81 of the mold 80 in a short time, and forms a film 92 a on the surface 81.
  • Substrate pressure mounting device 26 As shown in FIG. 7B, the board pressurizing and mounting apparatus 26 is composed of, for example, an articulated robot arm having a finger 26a for gripping the board 101 at the tip. The finger 26a grips the upper part of the substrate 101, and the second raw material liquid 92 does not adhere to the finger 26a when the substrate 101 is pressed against the second raw material liquid 92. Comparing FIG. 6C and FIG. 7A, when the first raw material liquid 91 in the recess 82 is dried, the volume is reduced and the upper surface of the tip portion 104 of the protrusion 103 is lower than the surface 81. It is in. That is, a space is formed on the tip portion 104 of the recess 82.
  • the second raw material liquid 92 enters the space of the recess 82 formed on the tip portion 104 by being pressurized by the substrate 101.
  • This step is a substrate assembly step (step S7) shown in FIG. Note that the thick arrow in FIG. 7B indicates the direction of pressure applied to the second raw material liquid 92 by the substrate 101.
  • the first dispenser 22 of the above-described molded body manufacturing apparatus 10 has a first raw material on the surface 81 of the mold 80 in which a plurality of recesses 82 are formed in the first supply step (step S2). It is an example of the 1st supply apparatus which supplies the liquid 91.
  • FIG. The plurality of protrusions 103 formed on the molded body 100 described above is an example of a plurality of protrusions, and the tip portion 104 of the protrusion 103 is formed by the first raw material liquid 91.
  • the next step is a drying step (step S4) in which the first raw material liquid 91 in the plurality of recesses 82 is dried by the first drying magazine 24 that is a drying device.
  • the second dispenser 25 described above is an example of a second supply device that supplies the second raw material liquid 92 to the surface 81 of the mold 80 dried with the first raw material liquid 91 by the first drying magazine 24. is there.
  • the base portion 105 and the laminated film 106 of the protrusion 103 are formed by the second raw material liquid 92.
  • the second raw material liquid 92 different from the first raw material liquid 91 it is easy to manufacture the molded body 100 having a different composition depending on the location in the protrusion 103 (the tip portion 104 and the base portion 105). become.
  • the protrusion 103 which is a convex portion has a conical shape, but the shape of the convex portion may be a shape other than a cone, for example, a pyramid, a cylinder, a prism, and a dome shape. May be.
  • the blade gripping mechanism 33 is configured such that the blade 31 can be fitted into the slit 33a and the blade 31 can be pulled out from the slit 33a, and the blade 31 can be detachably gripped.
  • the moving mechanism 34 moves the blade holding mechanism 33 relatively along the surface 81 of the mold 80 so that the first raw material liquid 91 is filled into the plurality of recesses 82 by the blade 31 held by the blade holding mechanism 33. It is configured so that it can be moved. In the above example, since the mold 80 is placed horizontally on the belt conveyor 21, the blade gripping mechanism 33 is moved horizontally in order to fill the plurality of concave portions 82 with the first raw material liquid 91.
  • the blade gripping mechanism 33 when the blade gripping mechanism 33 is moved horizontally, the first raw material liquid 91 because the angle between the blade 31 and the surface 81 of the mold 80 is an acute angle (0 ⁇ ⁇ 90) is contained in the recess 82. It is easy to be filled.
  • the blade stocker 30, the attachment mechanism 32, the removal mechanism 35, and the collection box 36 constitute the blade replacement mechanism 40.
  • the attachment mechanism 32 transports and attaches the blade 31 from the blade stocker 30 to the blade gripping mechanism 33, and the removal mechanism 35 removes the blade 31 from the blade gripping mechanism 33 and puts it in the collection box 36.
  • the blade 31 to which the first raw material liquid 91 is attached Before the operation of filling one raw material liquid 91, the blade 31 to which the first raw material liquid 91 is attached can be removed, and the blade 31 to which the first raw material liquid 91 is not attached can be attached. From the viewpoint of the manufacturing method, before the operation of moving the blade gripping mechanism 33 in the filling step (step S3-2) and filling the plurality of concave portions 82 of the mold 80 with the first raw material liquid 91, Through the blade replacement process (step S3-1), a new blade 31 to which the first raw material liquid 91 is not attached is attached to the blade gripping mechanism 33 in place of the blade 31 to which the first raw material liquid 91 is attached. .
  • the sanitary blade 31 to which the first raw material liquid 91 is not attached is always used to manufacture the concave portion 82 of the mold 80 with the first raw material liquid 91.
  • the sanitary blade 31 to which the first raw material liquid 91 is not attached is automatically conveyed from the blade stocker 30 to the blade gripping mechanism 33 by the mounting mechanism 32 and automatically attached to the blade gripping mechanism 33.
  • Hygiene can be improved by not allowing the operator to enter the work inside the isolator 11 for attaching the blade 31.
  • the blade to which the first raw material liquid 91 is attached can be automatically removed by the removing mechanism 35, and the hygiene is improved by preventing the worker from entering the work inside the isolator 11 for removing the blade 31. Can be achieved.
  • step S5 When forming a convex part only with the 1st raw material liquid 91, the process (step S5, S7, S8) before and behind the 2nd supply process (step S6) by the 2nd dispenser 25 is omitted.
  • step S6 when the first raw material liquid 91 is applied to the mold 80 with the blade 31, a gap is provided between the blade 31 and the surface 81 so that a laminated film is formed on the surface 81 of the mold 80 after drying. It is done.
  • step S2 the case where the protrusion 103 which is an example of the convex portion is formed using the first raw material liquid 91 and the second raw material liquid 92 has been described, but the third raw material liquid is added to the convex portion. May be formed.
  • the first dispenser 22 is used to fill the third raw material liquid. Processes similar to the supply process (step S2) to the drying process (step S4) are added.

Abstract

[Problem] To provide a molded-article production device and production method which make it easy to ensure sanitary conditions during the production of a molded article having a plurality of convexities. [Solution] Before moving a blade-gripping mechanism (33) using a movement mechanism (34) and filling a plurality of concavities 82 with a first starting material fluid (91), a blade-exchange mechanism (40) removes a blade (31) having the first starting material fluid (91) adhered thereto from the blade-gripping mechanism (33), and attaches a blade (31) not having the first starting material fluid (91) adhered thereto to the blade-gripping mechanism (33).

Description

成形体の製造装置及び成形体の製造方法Molded body manufacturing apparatus and molded body manufacturing method
 本発明は、複数の凸部を持つ成形体の製造装置及び製造方法に関し、特に、衛生的に複数の凸部を持つ成形体を製造するための製造装置及び製造方法に関する。 The present invention relates to a manufacturing apparatus and a manufacturing method of a molded body having a plurality of convex portions, and particularly relates to a manufacturing apparatus and a manufacturing method for manufacturing a molded body having a plurality of convex portions in a sanitary manner.
 従来から、食品や化粧品や薬剤などを製造する分野において、人間に与えられるものを含む成形体を製造する場合には、成形体を衛生的に製造することが求められている。例えば、化粧品や薬剤の分野において、皮膚の上に貼って皮膚を経由して体内に物質を導入するための経皮投与用貼付剤を製造する場合に、皮膚に直接触れる多数の突起を貼付剤の表面に形成することがある。例えば、特許文献1には、成形体の型であるスタンパの複数の凹部に、スキージを用いて原料を充填する技術が開示されている。特許文献1に開示されている技術は、これら複数の凹部に充填した液状の原料を固めて、成形体の表面に複数の凸部を形成するものである。 Conventionally, in the field of manufacturing foods, cosmetics, drugs, and the like, when manufacturing a molded body including a thing given to human beings, it is required to manufacture the molded body in a sanitary manner. For example, in the field of cosmetics and pharmaceuticals, when manufacturing a transdermal patch for applying a substance on the skin and introducing the substance into the body via the skin, the patch has a large number of protrusions that directly touch the skin. May form on the surface. For example, Patent Document 1 discloses a technique of filling a plurality of concave portions of a stamper, which is a mold of a molded body, with a raw material using a squeegee. In the technique disclosed in Patent Document 1, the liquid raw material filled in the plurality of recesses is solidified to form a plurality of projections on the surface of the molded body.
特開2012-2000572号公報JP 2012-2000572 A
 ところで、特許文献1に記載されているように、スキージを用いて凹部に原料を充填する場合、スキージに原料が付着することからスキージを清潔に保つのが難しくなる。また、スキージに付着する原料の変質を防止するのが難しい場合があり、変質した原料が成形体中に混入すると貼付剤の衛生状態が悪くなる原因ともなる。 By the way, as described in Patent Document 1, when a squeegee is used to fill a recess with a raw material, the raw material adheres to the squeegee, making it difficult to keep the squeegee clean. Moreover, it may be difficult to prevent the raw material adhering to the squeegee from being deteriorated, and when the deteriorated raw material is mixed in the molded article, the hygiene condition of the patch is deteriorated.
 本発明の課題は、複数の凸部を持つ成形体の製造において衛生状態を確保し易い成形体の製造装置及び製造方法を提供することにある。 An object of the present invention is to provide a manufacturing apparatus and a manufacturing method of a molded body that can easily ensure a sanitary state in manufacturing a molded body having a plurality of convex portions.
 以下に、課題を解決するための手段として複数の態様を説明する。これら態様は、必要に応じて任意に組み合せることができる。
 本発明の一見地に係る成形体の製造装置は、複数の凸部を持つ成形体を成形するための第1の原料液を、複数の凹部が表面に形成されている型の表面に供給する第1の供給装置と、ブレードを着脱自在に把持するブレード把持機構と、ブレード把持機構に把持されているブレードによって第1の原料液が複数の凹部に充填されるようにブレード把持機構を型の表面に沿って相対的に移動させる移動機構と、移動機構によってブレード把持機構を移動させて複数の凹部に第1の原料液を充填する前に、ブレード把持機構から第1の原料液が付着したブレードを取り外し、ブレード把持機構に第1の原料液の付着していないブレードを取り付けるブレード交換機構とを備えて構成されている。
 このように構成されている製造装置によれば、移動機構によってブレード把持機構が移動されて型の複数の凹部に第1の原料液が充填される動作の前に、ブレード把持機構には、第1の原料液が付着したブレードに換えて第1の原料液の付着していないブレードが取り付けられる。その結果、第1の原料液が付着していない衛生的なブレードを常に使用して型の凹部に第1の原料液を充填するような製造が可能になる。
Hereinafter, a plurality of modes will be described as means for solving the problems. These aspects can be arbitrarily combined as necessary.
The manufacturing apparatus of the molded object which concerns on one aspect of this invention supplies the 1st raw material liquid for shape | molding the molded object which has a several convex part to the surface of the type | mold with which the several recessed part is formed in the surface. The blade supply mechanism is configured so that the plurality of recesses are filled with the first raw material liquid by the first supply device, the blade gripping mechanism that detachably holds the blade, and the blade held by the blade holding mechanism. The first raw material liquid adheres from the blade holding mechanism before the blade holding mechanism is moved by the moving mechanism and the plurality of recesses are filled with the first raw material liquid. A blade exchanging mechanism for removing the blade and attaching the blade to which the first raw material liquid is not attached to the blade gripping mechanism is provided.
According to the manufacturing apparatus configured as described above, the blade gripping mechanism includes the first gripper before the operation in which the blade gripping mechanism is moved by the moving mechanism to fill the plurality of concave portions of the mold with the first raw material liquid. Instead of the blade with the first raw material liquid attached, a blade without the first raw material liquid attached is attached. As a result, it is possible to manufacture such that the first raw material liquid is filled in the concave portion of the mold by always using a sanitary blade to which the first raw material liquid is not attached.
 また、ブレード交換機構は、複数のブレードをストックするブレードストッカと、ブレードをブレードストッカからブレード把持機構まで搬送して取り付ける取付機構とを有するように構成されてもよい。このように構成された製造装置では、第1の原料液が付着していない衛生的なブレードをブレードストッカから取付機構でブレード把持機構まで自動的に搬送してブレード把持機構に自動的に取り付けられ、ブレードを取り付けるための作業を行う作業者を省くことで衛生面の向上を図ることができる。
 また、ブレード交換機構は、ブレード把持機構から第1の原料液が付着したブレードを取り外す取外し機構をさらに有するように構成されてもよい。このように構成された製造装置では、取外し機構によって自動的に第1の原料液が付着したブレードを取り外すことができ、ブレードを取り外すための作業を行う作業者を省くことで衛生面の向上を図ることができる。
 また、型の複数の凹部に充填された第1の原料液を乾燥させる乾燥装置と、乾燥装置で複数の凹部の第1の原料液が乾燥された型の表面に第2の原料液を供給する第2の供給装置とをさらに備えるように製造装置が構成されてもよい。このように構成された製造装置では、第1の原料液とは異なる第2の原料液を第2の供給装置で供給できるので、凸部内の場所によって凸部を形成する組成の異なる成形体の製造が容易になる。
The blade replacement mechanism may be configured to include a blade stocker that stocks a plurality of blades, and an attachment mechanism that transports and attaches the blades from the blade stocker to the blade gripping mechanism. In the manufacturing apparatus configured as described above, a sanitary blade to which the first raw material liquid is not attached is automatically conveyed from the blade stocker to the blade gripping mechanism by the mounting mechanism, and is automatically attached to the blade gripping mechanism. The sanitary aspect can be improved by omitting the worker who performs the work for attaching the blade.
In addition, the blade replacement mechanism may be configured to further include a removal mechanism for removing the blade to which the first raw material liquid has adhered from the blade gripping mechanism. In the manufacturing apparatus configured as described above, the blade to which the first raw material liquid is attached can be automatically removed by the removal mechanism, and the hygiene can be improved by omitting the worker who performs the work for removing the blade. Can be planned.
Also, a drying device for drying the first raw material liquid filled in the plurality of concave portions of the mold, and a second raw material liquid is supplied to the surface of the mold where the first raw material liquid in the plurality of concave portions is dried by the drying device. The manufacturing apparatus may be configured to further include a second supply device. In the manufacturing apparatus configured as described above, since the second raw material liquid different from the first raw material liquid can be supplied by the second supply device, the molded body having a different composition that forms the convex portion depending on the location in the convex portion. Easy to manufacture.
 本発明の一見地に係る成形体の製造方法は、複数の凸部を持つ成形体を成形するための第1の原料液を、複数の凹部が表面に形成されている型の表面に供給する第1の供給工程と、ブレード把持機構に把持されているブレードを型の表面に沿って相対的に移動させて、ブレードによって型の複数の凹部に第1の原料液を充填する充填工程と、充填工程の前に、第1の原料液が付着したブレードをブレード把持機構から取り外し、第1の原料液の付着していないブレードをブレード把持機構に取り付けるブレード交換工程とを備えて構成されている。
 このように構成されている製造方法によれば、充填工程でブレード把持機構が移動されて型の複数の凹部に第1の原料液が充填される動作の前に、ブレード交換工程によって、ブレード把持機構には、第1の原料液が付着したブレードに換えて第1の原料液の付着していないブレードが取り付けられる。その結果、第1の原料液が付着していない衛生的なブレードを常に使用して型の凹部に第1の原料液を充填するような製造が可能になる。
The manufacturing method of the molded object which concerns on one aspect of this invention supplies the 1st raw material liquid for shape | molding the molded object which has a several convex part to the surface of the type | mold with which the several recessed part is formed in the surface. A first supply step, a filling step in which the blade held by the blade holding mechanism is relatively moved along the surface of the mold, and the plurality of concave portions of the mold are filled with the first raw material liquid by the blade; Before the filling step, the blade is attached to the blade gripping mechanism by removing the blade to which the first raw material liquid adheres, and the blade replacement step for attaching the blade to which the first raw material liquid is not attached to the blade gripping mechanism. .
According to the manufacturing method configured as described above, the blade gripping mechanism is moved by the blade replacement step before the operation of filling the plurality of concave portions of the mold with the first raw material liquid in the filling step. A blade to which the first raw material liquid is not attached is attached to the mechanism in place of the blade to which the first raw material liquid is attached. As a result, it is possible to manufacture such that the first raw material liquid is filled in the concave portion of the mold by always using a sanitary blade to which the first raw material liquid is not attached.
 また、型の複数の凹部に充填された第1の原料液を乾燥させる乾燥工程と、乾燥工程で複数の凹部の第1の原料液が乾燥された型の表面に第2の原料液を供給する第2の供給工程とをさらに備えるように製造方法が構成されてもよい。このように構成された製造方法では、第1の原料液とは異なる第2の原料液を第2の供給工程で供給できるので、凸部内の場所によって凸部を形成する組成が異なる成形体の製造が容易になる。 In addition, a drying process for drying the first raw material liquid filled in the plurality of concave portions of the mold, and a second raw material liquid is supplied to the surface of the mold where the first raw material liquid in the plurality of concave sections is dried in the drying process. The manufacturing method may be configured to further include a second supplying step. In the manufacturing method configured as described above, since the second raw material liquid different from the first raw material liquid can be supplied in the second supply step, the composition forming the convex portion differs depending on the location in the convex portion. Easy to manufacture.
 本発明に係る成形体の製造装置又は成形体の製造方法は、複数の凸部を持つ成形体の製造において衛生状態を確保し易くなるという効果を奏する。 The molded body manufacturing apparatus or the molded body manufacturing method according to the present invention has an effect that it is easy to ensure a sanitary state in manufacturing a molded body having a plurality of convex portions.
本発明の一実施形態に係る成形体の製造装置の一例を示す模式図。The schematic diagram which shows an example of the manufacturing apparatus of the molded object which concerns on one Embodiment of this invention. 図1の製造装置で製造される成形体の一例を示す斜視図。The perspective view which shows an example of the molded object manufactured with the manufacturing apparatus of FIG. 図2に示されている成形体の一部を拡大した部分拡大斜視図。The partial expansion perspective view which expanded a part of the molded object shown by FIG. 一実施形態に係る成形体の製造工程を説明するためのフローチャート。The flowchart for demonstrating the manufacturing process of the molded object which concerns on one Embodiment. 充填部の具体例を説明するための斜視図。The perspective view for demonstrating the specific example of a filling part. (a)第1の供給工程を説明するための模式的な断面図、(b)充填工程を説明するための模式的な断面図、(c)充填工程を説明するための模式的な断面図。(A) Schematic cross-sectional view for explaining the first supply step, (b) Schematic cross-sectional view for explaining the filling step, (c) Schematic cross-sectional view for explaining the filling step . (a)第2の供給工程を説明するための模式的な断面図、(b)基板アセンブリ工程を説明するための模式的な断面図、(c)第2の乾燥用マガジンで乾燥する工程を説明するための模式的な断面図。(A) A schematic cross-sectional view for explaining the second supply step, (b) a schematic cross-sectional view for explaining the substrate assembly step, and (c) a step of drying with the second drying magazine. A typical sectional view for explaining.
(1)成形体の製造装置の概要
 まず、本発明の一実施形態に係る成形体の製造装置の概要について図1を用いて説明する。図1の成形体の製造装置10で製造される成形体は、例えば、薬剤の投与に用いられる経皮投与用貼付剤の薬剤を含む成形体である。この実施形態で説明する成形体100は、図2及び図3に示されているように、板状の基板101の表面102に、互いに異なる2種類の層が積層された錐体状の突起103が複数形成されている形状を持っている。基板101は、通気性の良い部材であり、例えば多孔質部材である。なお、図3には図2の一部領域Ar1が拡大して示されている。錐体状の突起103は、先端部分104と基台部分105とで、組成及び/又は性状が異なっている。このように先端部分104と基台部分105の2層構成を実現するため、製造装置10は、2種類の原料液を塗布する機能を有している。基板101の表面102には、基台部分105と同じ組成の積層膜106が形成されている。
 成形体の製造装置10は、内部の作業空間を無菌状態に保つアイソレータ11と、アイソレータ11の前後に設けられているアイソレータ前室12及びアイソレータ後室13とを備えている。アイソレータ11は、例えば、作業空間11aの雰囲気を無菌かつ温度25℃湿度70%に維持することができる。アイソレータ前室12及びアイソレータ後室13は、例えば外部からアイソレータ11に通じる除染パスボックスであり、内部空間12a,13aを滅菌する機能を有している。
(1) Outline of Molded Body Manufacturing Apparatus First, an outline of a molded body manufacturing apparatus according to an embodiment of the present invention will be described with reference to FIG. The molded body manufactured by the molded body manufacturing apparatus 10 of FIG. 1 is, for example, a molded body containing a drug for a transdermal patch used for drug administration. As shown in FIGS. 2 and 3, the molded body 100 described in this embodiment includes a cone-shaped protrusion 103 in which two different types of layers are stacked on a surface 102 of a plate-like substrate 101. Has a shape in which a plurality of are formed. The substrate 101 is a member having good air permeability, for example, a porous member. In FIG. 3, the partial area Ar1 of FIG. 2 is shown enlarged. The cone-shaped protrusion 103 differs in composition and / or property between the tip portion 104 and the base portion 105. Thus, in order to realize the two-layer configuration of the tip portion 104 and the base portion 105, the manufacturing apparatus 10 has a function of applying two types of raw material liquids. A laminated film 106 having the same composition as the base portion 105 is formed on the surface 102 of the substrate 101.
The molded body manufacturing apparatus 10 includes an isolator 11 that keeps an internal working space in a sterile state, and an isolator front chamber 12 and an isolator rear chamber 13 that are provided before and after the isolator 11. For example, the isolator 11 can maintain the atmosphere of the work space 11a aseptically at a temperature of 25 ° C. and a humidity of 70%. The isolator front chamber 12 and the isolator rear chamber 13 are decontamination pass boxes that communicate with the isolator 11 from the outside, for example, and have a function of sterilizing the internal spaces 12a and 13a.
(1-1)アイソレータ前室12
 アイソレータ前室12が外部に対して開放可能に構成されており、開放されたアイソレータ前室12の内部空間12aには複数の型80を収納できる前室用マガジン14が装着できる。アイソレータ前室12に収納された複数の型80は、前室用マガジン14とともに、アイソレータ前室12の内部空間12aを外部及びアイソレータ11に対して密封状態にして滅菌される。アイソレータ前室12が外部に解放されているときには、アイソレータ前室12からアイソレータ11に繋がる通路12bが封鎖された状態になる。
 アイソレータ前室12に装着された前室用マガジン14に収納されている型80は、アイソレータ11の作業空間11aの型供給用マガジン20に移動できる。アイソレータ前室12からアイソレータ11に前室用マガジン14が移動するときには、アイソレータ前室12が外部の空間に対して封鎖され、アイソレータ前室12とアイソレータ11の間の通路12bが連通する。
(1-1) Isolator front chamber 12
The isolator front chamber 12 is configured to be openable to the outside, and a front chamber magazine 14 that can store a plurality of molds 80 can be mounted in the open internal space 12a of the isolator front chamber 12. The plurality of molds 80 housed in the isolator front chamber 12 are sterilized together with the front chamber magazine 14 with the internal space 12a of the isolator front chamber 12 sealed against the outside and the isolator 11. When the isolator front chamber 12 is open to the outside, the passage 12b connected from the isolator front chamber 12 to the isolator 11 is blocked.
The mold 80 accommodated in the front chamber magazine 14 mounted in the isolator front chamber 12 can be moved to the mold supply magazine 20 in the work space 11 a of the isolator 11. When the front chamber magazine 14 moves from the isolator front chamber 12 to the isolator 11, the isolator front chamber 12 is blocked from the external space, and the passage 12 b between the isolator front chamber 12 and the isolator 11 communicates.
(1-2)アイソレータ11
 アイソレータ11には、前述の型供給用マガジン20とともに、ベルトコンベア21,27と、第1のディスペンサ22と、充填部23と、第1の乾燥用マガジン24と、第2のディスペンサ25と、基板加圧実装装置26と、第2の乾燥用マガジン28とが装備されている。
 アイソレータ11の型供給用マガジン20に移動した型80は、ローダ(図示せず)によってベルトコンベア21に載置される。ベルトコンベア21は、第1のディスペンサ22に型80をディスペンス位置P1(図5参照)に搬送して自動的に停止する。
(1-2) Isolator 11
The isolator 11 includes belt conveyors 21 and 27, a first dispenser 22, a filling unit 23, a first drying magazine 24, a second dispenser 25, a substrate, as well as the above-described mold supply magazine 20. A pressure mounting device 26 and a second drying magazine 28 are provided.
The mold 80 moved to the mold supply magazine 20 of the isolator 11 is placed on the belt conveyor 21 by a loader (not shown). The belt conveyor 21 conveys the mold 80 to the first dispenser 22 to the dispensing position P1 (see FIG. 5) and automatically stops.
 第1のディスペンサ22は、人体に導入するための化学物質が含まれる第1の原料液91を所定量だけ型80の表面に吐出する(図6(a)参照)。
 第1の原料液91が塗布された型80は、ベルトコンベア21によって充填部23に自動的に搬送される。充填部23では、ブレード31によって、型80の凹部の中にまで十分に第1の原料液91が充填される(図6(b)及び図6(c)参照)。ただし、型80の表面の第1の原料液がブレード31によってほぼ全て掻き取られるので、型80の表面に第1の原料液91はほとんど残らない。
 凹部に第1の原料液91が充填された型80は、ベルトコンベア21によって第1の乾燥用マガジン24の近傍に自動的に搬送され、例えばアンローダ(図示せず)によって第1の乾燥用マガジン24に収納される。そして、第1の乾燥用マガジン24に先にストックされたものから順次取り出されて、次の第2のディスペンサ25に例えばローダ(図示せず)によって自動的に載置される。第1の乾燥用マガジン24にストックされている間に、型80の凹部に充填された第1の原料液91が乾燥される。図6(c)と図7(a)とを比較すると分かるように、この第1の原料液91は、乾燥される際に体積が減少する。
The first dispenser 22 discharges a predetermined amount of the first raw material liquid 91 containing a chemical substance to be introduced into the human body onto the surface of the mold 80 (see FIG. 6A).
The mold 80 coated with the first raw material liquid 91 is automatically conveyed to the filling unit 23 by the belt conveyor 21. In the filling unit 23, the first raw material liquid 91 is sufficiently filled into the concave portion of the mold 80 by the blade 31 (see FIGS. 6B and 6C). However, since almost all of the first raw material liquid on the surface of the mold 80 is scraped off by the blade 31, the first raw material liquid 91 hardly remains on the surface of the mold 80.
The mold 80 in which the concave portion is filled with the first raw material liquid 91 is automatically transported to the vicinity of the first drying magazine 24 by the belt conveyor 21 and, for example, the first drying magazine by an unloader (not shown). 24. Then, the first stock in the first drying magazine 24 is sequentially taken out, and is automatically placed on the next second dispenser 25 by, for example, a loader (not shown). While being stocked in the first drying magazine 24, the first raw material liquid 91 filled in the recesses of the mold 80 is dried. As can be seen from a comparison between FIG. 6C and FIG. 7A, the volume of the first raw material liquid 91 decreases when it is dried.
 第2のディスペンサ25は、人体に導入するための化学物質が含まれる第2の原料液92を所定量だけ型80の表面に吐出する(図7(a)参照)。
 第2の原料液92が塗布された型80は、例えばベルトコンベア27によって第2のディスペンサ25から基板加圧実装装置26に自動的に搬送される。基板加圧実装装置26では、型80の表面に吐出された第2の原料液92の上に、例えばロボットアームによって基板101が乾燥前の第2の原料液92に押し付けられて密接させられる(図7(b)参照)。
 基板101が実装された状態で、型80は、ベルトコンベア27によって基板加圧実装装置26から第2の乾燥用マガジン28の近傍に自動的に搬送され、例えばアンローダ(図示せず)によって第2の乾燥用マガジン28に収納される。第2の乾燥用マガジン28は、基板加圧実装装置26までのエリアから隔絶されたアイソレータ11の乾燥ストックエリア11bに配置されている。この乾燥ストックエリア11bは、乾燥を促進するために、アイソレータ11の作業空間11aよりも高い温度と低い湿度に保たれている。
The second dispenser 25 discharges a predetermined amount of a second raw material liquid 92 containing a chemical substance to be introduced into the human body onto the surface of the mold 80 (see FIG. 7A).
The mold 80 to which the second raw material liquid 92 is applied is automatically conveyed from the second dispenser 25 to the substrate pressure mounting apparatus 26 by, for example, the belt conveyor 27. In the substrate pressing and mounting apparatus 26, the substrate 101 is pressed and brought into close contact with the second raw material liquid 92 before drying on the second raw material liquid 92 discharged onto the surface of the mold 80 by, for example, a robot arm (see FIG. (Refer FIG.7 (b)).
In a state in which the substrate 101 is mounted, the mold 80 is automatically conveyed from the substrate pressure mounting device 26 to the vicinity of the second drying magazine 28 by the belt conveyor 27, and is secondly transferred by, for example, an unloader (not shown). Are stored in the drying magazine 28. The second drying magazine 28 is disposed in the dry stock area 11 b of the isolator 11 that is isolated from the area up to the substrate pressure mounting device 26. The dry stock area 11b is maintained at a higher temperature and lower humidity than the work space 11a of the isolator 11 in order to promote drying.
(1-2-1)アイソレータ11での各工程
 以上説明したアイソレータ11及びそれに続く製造工程を簡単にまとめると、図4に示されているようになる。
 まず、ステップS1では、ベルトコンベア27を使って第1のディスペンサ22に型80がセットされる。第1の供給工程(ステップS2)では、第1のディスペンサ22で第1の原料液91が型80に供給される。次のステップS3は、ステップS3-1のブレード交換工程と、ステップS3-2のブレードによる凹部への充填工程とを含んでいる。これらステップS3-1,S3-2については後ほど詳しく説明する。その次の乾燥工程(ステップS4)では、凹部に第1の原料液91が充填された型80は、第1の乾燥用マガジン24に収納されている間に第1の原料液91の乾燥が行われる。ステップS5では、凹部の第1の原料液91が乾燥した型80は、ベルトコンベア27で第2のディスペンサ25にセットされる。第2の供給工程(ステップS6)では、第2のディスペンサ25で第2の原料液92が型80に供給される。ステップS7で、基板101が第2の原料液92の上に押し付けられる。ステップS8で、第2の原料液92が表面に吐出された型80は、第2の乾燥用マガジン28に収納されている間に第2の原料液92の乾燥が行われる。乾燥後のステップS9は、アイソレータ後室13から後室用マガジン15が取り出された後の工程であり、型80に形成されている成形体の抜き加工が行われ、成形体のパッケージングが行われる。
(1-2-1) Steps in Isolator 11 The above-described isolator 11 and the subsequent manufacturing steps are summarized as shown in FIG.
First, in step S <b> 1, the mold 80 is set in the first dispenser 22 using the belt conveyor 27. In the first supply process (step S <b> 2), the first raw material liquid 91 is supplied to the mold 80 by the first dispenser 22. The next step S3 includes the blade replacement step of step S3-1 and the step of filling the recess with the blade of step S3-2. These steps S3-1 and S3-2 will be described in detail later. In the subsequent drying step (step S4), the mold 80 in which the concave portion is filled with the first raw material liquid 91 is dried in the first raw material liquid 91 while being stored in the first drying magazine 24. Done. In step S <b> 5, the mold 80 from which the first raw material liquid 91 in the recess is dried is set in the second dispenser 25 by the belt conveyor 27. In the second supply process (step S <b> 6), the second raw material liquid 92 is supplied to the mold 80 by the second dispenser 25. In step S <b> 7, the substrate 101 is pressed onto the second raw material liquid 92. In step S <b> 8, the second raw material liquid 92 is dried while the mold 80 on which the second raw material liquid 92 is discharged onto the surface is stored in the second drying magazine 28. Step S9 after drying is a process after the rear chamber magazine 15 is taken out from the isolator rear chamber 13, and the molded body formed in the mold 80 is punched and the molded body is packaged. Is called.
(1-3)アイソレータ後室13
 アイソレータ後室13は、外部に対して開放可能に構成されており、開放されたアイソレータ後室13の内部空間13aから後室用マガジン15を取り出すことができる。後室用マガジン15は、アイソレータ11の乾燥ストックエリア11bの第2の乾燥用マガジン28からアイソレータ後室13に移動されてくる型80を収納できる。アイソレータ11からアイソレータ後室13に型80が移動するときには、アイソレータ11からアイソレータ後室13に繋がる通路13bが連通し、アイソレータ後室13が外部の空間に対して封鎖される。そして、アイソレータ後室13が外部に解放されているときには、アイソレータ後室13からアイソレータ11に繋がる通路13bが封鎖された状態になる。アイソレータ後室13が外部に開放された後には滅菌が行われる。
(1-3) Isolator rear chamber 13
The isolator rear chamber 13 is configured to be openable to the outside, and the rear chamber magazine 15 can be taken out from the internal space 13 a of the opened isolator rear chamber 13. The rear chamber magazine 15 can accommodate the mold 80 moved from the second drying magazine 28 in the drying stock area 11 b of the isolator 11 to the isolator rear chamber 13. When the mold 80 moves from the isolator 11 to the isolator rear chamber 13, the passage 13 b connected from the isolator 11 to the isolator rear chamber 13 communicates, and the isolator rear chamber 13 is sealed off from the external space. When the isolator rear chamber 13 is released to the outside, the passage 13b connected from the isolator rear chamber 13 to the isolator 11 is sealed. After the isolator rear chamber 13 is opened to the outside, sterilization is performed.
(1-4)アイソレータ後室13の後段の処理について
 アイソレータ後室13から取り出された後室用マガジン15には、型80に嵌った状態の成形体が収納されている。例えば、成形体が収納されている後室用マガジン15を衛生的な状態(例えば無菌状態)で密封して商品として流通させることができる。また、上述のステップS9の工程を経ることで、型80から成形体を外して成形体をそのまま衛生的な状態(例えば無菌状態)で包装するか又は成形体を他の部材と組み合わせるアセンブリを行った後に衛生的な状態(例えば無菌状態)で包装し、包装された状態の成形体を製品として流通させることもできる。さらに、型80を包装部材の一部として利用して、型80に嵌ったまま衛生的な状態(例えば無菌状態)で包装するか又は型80に嵌ったまま成形体を他の部材と組み合わせるアセンブリを行った後に衛生的な状態(例えば無菌状態)で包装し、包装された状態の成形体と型80を製品として流通させることもできる。
 なお、図1には示されていないが、アイソレータ後室13以降も衛生的な状態を保つために、例えば、アイソレータ後室13以降もクリーンルーム内で機械に作業を行わせたり、アイソレータ後室13の後段に他のアイソレータを接続して作業を行わせたりするなど、衛生的な環境で作業が継続される。
(1-4) Processing in the latter stage of the isolator rear chamber 13 The rear chamber magazine 15 taken out from the isolator rear chamber 13 contains a molded body fitted in the mold 80. For example, the rear chamber magazine 15 in which the molded body is stored can be sealed in a hygienic state (for example, aseptic) and distributed as a product. Further, by performing the above-described step S9, the molded body is removed from the mold 80, and the molded body is packaged in a sanitary state (for example, aseptic condition) or the molded body is assembled with other members. After that, it can be packaged in a sanitary state (for example, aseptic), and the molded product in the packaged state can be distributed as a product. Further, an assembly in which the mold 80 is used as a part of the packaging member and is packaged in a hygienic state (for example, aseptic) while being fitted to the mold 80, or the molded body is combined with other members while being fitted to the mold 80. It is possible to wrap the product in a sanitary state (for example, aseptic condition) and to distribute the packaged molded product 80 and the mold 80 as a product.
Although not shown in FIG. 1, in order to maintain a hygienic state after the isolator rear chamber 13, for example, the machine is also operated in the clean room after the isolator rear chamber 13 or after the isolator rear chamber 13. The work is continued in a hygienic environment, such as by connecting another isolator to the subsequent stage.
(2)型80
 型80は、原料液におかされない衛生的な材料で形成されていればよいが、例えばプラスチック、セラミック又は金属で形成できる。型80を形成するプラスチックとしては、例えばポリエチレン又はポリプロピレンが挙げられ、型80を形成する金属としては例えばステンレスが挙げられる。型80の凹部には、例えば円形、多角形及び楕円形の断面形状を有する円錐状又は角錐状の空間が形成される。
(2) Mold 80
The mold 80 may be formed of a sanitary material that is not exposed to the raw material liquid, but can be formed of, for example, plastic, ceramic, or metal. Examples of the plastic forming the mold 80 include polyethylene or polypropylene, and examples of the metal forming the mold 80 include stainless steel. In the concave portion of the mold 80, for example, a conical or pyramidal space having a circular, polygonal, and elliptical cross-sectional shape is formed.
(3)原料液
 第1の原料液91は、例えば水、水とアルコールの混合溶液又は他の溶媒に固形の原材料を溶かし込んだものである。固形の原材料としては、人体に無害な高分子物質であり、例えば、人体に無害な樹脂、人体に無害な多糖類及び人体に無害なタンパク質並びにそれらに由来する人体に無害な化合物が含まれる。第1の原料液91は、例えば水溶性の多糖類、水溶性のタンパク質、ポリビニルアルコール、カルボキシビニルポリマー及びポリアクリル酸ナトリウムのうちの少なくとも一つを水に溶かしたものである。水溶性の多糖類としては、例えばコンドロイチン硫酸ナトリウムがあり、水溶性のタンパク質としては、例えば血清アルブミンがある。人体に導入するための化学物質としては、例えば傷病の治療や診断や予防目的のために用いられる生物活性物質が挙げられる。このような生物活性物質としては、例えばインスリンや成長ホルモンなどがある。
 第2の原料液92は、化学物質の種類、化学物質の含有量、固形の原材料及び溶媒のうちの少なくとも一つが第1の原料液91とは異なっている。このように第1の原料液91と第2の原料液92とを異ならせることで、錐体状の突起103は、先端部分104と基台部分105の組成及び/又は性状を異ならせる。例えば、化学物質の種類、化学物質の含有量及び固形の原材料のうちの少なくとも一つの相違によって、先端部分104と基台部分105の組成が相違する。また、例えば溶媒や乾燥の仕方を異ならせることで乾燥後の状態を変えて例えば溶解性を異ならせれば、先端部分104と基台部分105が同じ組成であっても互いに性状の異なるものにすることができる。
(3) Raw material liquid The first raw material liquid 91 is obtained by dissolving solid raw materials in, for example, water, a mixed solution of water and alcohol, or another solvent. Solid raw materials are polymer substances that are harmless to the human body, and include, for example, resins that are harmless to the human body, polysaccharides that are harmless to the human body, proteins that are harmless to the human body, and compounds derived therefrom that are harmless to the human body. The first raw material liquid 91 is obtained by, for example, dissolving at least one of water-soluble polysaccharides, water-soluble proteins, polyvinyl alcohol, carboxyvinyl polymer, and sodium polyacrylate in water. An example of the water-soluble polysaccharide is sodium chondroitin sulfate, and an example of the water-soluble protein is serum albumin. Examples of the chemical substance to be introduced into the human body include biologically active substances used for the purpose of treatment, diagnosis and prevention of wounds. Examples of such biologically active substances include insulin and growth hormone.
The second raw material liquid 92 is different from the first raw material liquid 91 in at least one of the kind of chemical substance, the content of the chemical substance, the solid raw material, and the solvent. Thus, by making the first raw material liquid 91 and the second raw material liquid 92 different from each other, the cone-shaped protrusion 103 changes the composition and / or properties of the tip portion 104 and the base portion 105. For example, the composition of the tip portion 104 and the base portion 105 differs depending on at least one of the kind of chemical substance, the content of the chemical substance, and the solid raw material. Also, for example, by changing the state after drying by changing the solvent and the drying method, for example, by making the solubility different, even if the tip portion 104 and the base portion 105 have the same composition, they have different properties. be able to.
(4)充填部23
 図5を用いて、充填部23の具体的な構成例について説明する。図5に示されている太い矢印は、ブレード31の移動方向を示している。
 充填部23には、ブレードストッカ30と、ブレードストッカ30にストックされている複数のブレード31と、取付機構32と、ブレード把持機構33と、移動機構34と、取外し機構35と、回収ボックス36とが設置されている。
(4) Filling unit 23
A specific configuration example of the filling unit 23 will be described with reference to FIG. A thick arrow shown in FIG. 5 indicates the moving direction of the blade 31.
The filling unit 23 includes a blade stocker 30, a plurality of blades 31 stocked in the blade stocker 30, an attachment mechanism 32, a blade gripping mechanism 33, a moving mechanism 34, a removal mechanism 35, and a collection box 36. Is installed.
(4-1)ブレードストッカ30
 ブレードストッカ30は、所定のストック位置P10に複数のブレード31を貯えておくための装置である。図4に示されているブレードストッカ30は、水平に重ねられた複数のブレード31の四隅に当接するガイドフレーム30aを有している。ブレード31は、平面視において長方形をしており、また長辺の一つに向かって厚みが薄くなっていて断面楔形の形状を呈する。この薄くなっている方の一辺がブレード31の刃先になる。4本のガイドフレーム30aは、鉛直上方に向かって延びている。ブレード31は、ブレードストッカ30の最上段に載置されているものから順に取付機構32によって搬送されるが、ブレードストッカ30から取り出されるときには、取付機構32によって一旦ガイドフレーム30aに沿って鉛直上方に持ち上げられる。 
(4-1) Blade stocker 30
The blade stocker 30 is a device for storing a plurality of blades 31 at a predetermined stock position P10. The blade stocker 30 shown in FIG. 4 has guide frames 30a that come into contact with the four corners of a plurality of blades 31 that are horizontally stacked. The blade 31 has a rectangular shape in plan view, and has a wedge-shaped cross section with a thickness decreasing toward one of the long sides. One side of the thinner side is the cutting edge of the blade 31. The four guide frames 30a extend vertically upward. The blades 31 are conveyed by the attachment mechanism 32 in order from the one mounted on the uppermost stage of the blade stocker 30. When the blades 31 are taken out from the blade stocker 30, the attachment mechanism 32 temporarily moves vertically upward along the guide frame 30a. Lifted.
(4-2)取付機構32 取付機構32は、例えば半球状をしたゴム製の2つの吸着盤32aを備えている。これら吸着盤32aは、内部を真空状態にすることによりブレード31の上面に吸着することができるように構成されている。ところで、取付機構32は、ストック位置P10に2つの吸着盤32aの位置を合わせる機能を備えているので、常に吸着盤32aによってブレード31上面の所定箇所を真空吸着して搬送することができる。取付機構32は、ブレードストッカ30から鉛直上方に所定距離だけ移動させた後、ブレード31を水平方向に移動させて所定位置で待機しているブレード把持機構33のスリット33a(図6(b)参照)に差し込む。 (4-2) Attachment Mechanism 32 The attachment mechanism 32 includes two suction cups 32a made of rubber, for example, hemispherical. These suction disks 32a are configured to be able to be sucked onto the upper surface of the blade 31 by making the inside vacuum. By the way, since the attachment mechanism 32 has a function of aligning the positions of the two suction disks 32a with the stock position P10, the suction disk 32a can always convey a predetermined portion of the upper surface of the blade 31 by vacuum suction. The attachment mechanism 32 is moved vertically upward from the blade stocker 30 by a predetermined distance, and then moves the blade 31 in the horizontal direction to wait for a predetermined position at the slit 33a of the blade gripping mechanism 33 (see FIG. 6B). ).
(4-3)ブレード把持機構33
 ブレード把持機構33は、例えば、弾性を有するプラスチック製の直方体状の棒状部材である。ブレード把持機構33のスリット33aは、直方体の一面を長手方向に沿って横断しており、一面からの深さが一定になっている。そのため、平面視長方形状のブレード31をスリット33aの最深部に当接させることで、ブレード31の刃先からスリット33aの横断しているブレード把持機構33の一面までの距離が刃先の任意の箇所で一定になる。つまり、ブレード把持機構33から突出しているブレード31の形状も平面視長方形になる。
 ブレード把持機構33のスリット33aの対向面には、例えば厚さ一定のゴム(図示せず)がそれぞれ貼り付けられている。このようなスリット33aにブレード31が差し込まれると、対向面のゴムに挟まれてブレード31が把持される。または、ブレード把持機構33は、例えば上述のゴムが貼り付けられなくても、ブレード把持機構33に弾性変形し易い材質を用い、ブレード31をスリット33aに挿入する際にブレード把持機構33が弾性変形するように構成することで、スリット33aの対向面間にブレード31が挟まれて把持されることもできる。なお、後述する移動機構34の一例であるロボットアームのフィンガ34aがブレード把持機構33を掴む力を、ブレード把持機構33がブレード31を把持して保持する補助力に用いてもよい。
(4-3) Blade gripping mechanism 33
The blade gripping mechanism 33 is, for example, a plastic rectangular parallelepiped rod-shaped member having elasticity. The slit 33a of the blade gripping mechanism 33 crosses one surface of the rectangular parallelepiped along the longitudinal direction, and the depth from the one surface is constant. Therefore, when the blade 31 having a rectangular shape in plan view is brought into contact with the deepest portion of the slit 33a, the distance from the blade edge of the blade 31 to one surface of the blade gripping mechanism 33 crossed by the slit 33a is at an arbitrary position of the blade edge. It becomes constant. That is, the shape of the blade 31 protruding from the blade gripping mechanism 33 is also rectangular in plan view.
For example, rubber (not shown) with a constant thickness is attached to the surface of the blade gripping mechanism 33 facing the slit 33a. When the blade 31 is inserted into such a slit 33a, the blade 31 is gripped by being sandwiched between rubbers on the opposing surface. Alternatively, the blade gripping mechanism 33 uses, for example, a material that is easily elastically deformed even when the above-described rubber is not attached, and the blade gripping mechanism 33 is elastically deformed when the blade 31 is inserted into the slit 33a. By configuring so, the blade 31 can be sandwiched and held between the opposing surfaces of the slit 33a. Note that a force that a finger 34a of a robot arm, which is an example of a moving mechanism 34 described later, grips the blade gripping mechanism 33 may be used as an auxiliary force that the blade gripping mechanism 33 grips and holds the blade 31.
(4-4)移動機構34
 移動機構34は、例えばブレード把持機構33を掴むフィンガ34aを先端に有する多関節のロボットアームで構成される。移動機構34は、次の(a)~(d)の動作を行なう。
 (a)ブレード把持機構33のスリット33aの対向面が水平になるようにブレード把持機構33を移動して、ブレードストッカ30に水平に重ねられているブレード31の方にスリット33aが形成されている面を向けてブレード把持機構33を固定する。
 (b)取付機構32と協働して、ブレード31をスリット33aに差し込み、ブレード31がスリット33aの最深部に当接するまでブレード31を押し込む。
 (c)型80の表面に対して所定の角度θ(図7(c)参照)を保ってブレード31を型80の表面81に沿って水平に移動させる。この角度θは鋭角である。このブレード31の水平移動のときに、ブレード31は、進行方向に沿って切断した鉛直断面が進行方向に対して斜めに傾いて移動して第1の原料液91に接触する。その結果、ブレード31によって複数の凹部82(図6参照)に第1の原料液91が押し込まれて充填される。上述の水平移動のとき、ブレード31は、型80の表面81に接触させるが、成形体100の表面102に第1の原料液91を乾燥させた組成物を形成したいときにはブレード31を型80の表面81に接触させない場合もある。図5においては、ブレード31によって第1の原料液91を示す円が単に広がっているように記載されているが、これらの円は、円に囲まれた領域内にある複数の凹部に第1の原料液91が充填され、凹部の周囲の表面には第1の原料液91が残っていない状態を模式的に示すものである。
 (d)第1の原料液91を充填するために(c)で説明したように水平にブレード把持機構33を所定距離だけ水平に移動した後、ブレード31を型80の表面から離すように上方に移動させる。ブレード31を型80から離した後に、回収ボックス36の上方にブレード把持機構33を移動させる。
(4-4) Moving mechanism 34
The moving mechanism 34 is composed of, for example, an articulated robot arm having a finger 34a for gripping the blade gripping mechanism 33 at the tip. The moving mechanism 34 performs the following operations (a) to (d).
(A) The blade gripping mechanism 33 is moved so that the surface facing the slit 33a of the blade gripping mechanism 33 is horizontal, and a slit 33a is formed on the blade 31 that is horizontally stacked on the blade stocker 30. The blade gripping mechanism 33 is fixed with the surface facing.
(B) In cooperation with the attachment mechanism 32, the blade 31 is inserted into the slit 33a, and the blade 31 is pushed in until the blade 31 contacts the deepest portion of the slit 33a.
(C) The blade 31 is moved horizontally along the surface 81 of the mold 80 while maintaining a predetermined angle θ (see FIG. 7C) with respect to the surface of the mold 80. This angle θ is an acute angle. During the horizontal movement of the blade 31, the blade 31 moves while the vertical cross section cut along the traveling direction is inclined with respect to the traveling direction and contacts the first raw material liquid 91. As a result, the first raw material liquid 91 is pushed and filled into the plurality of recesses 82 (see FIG. 6) by the blade 31. During the horizontal movement described above, the blade 31 is brought into contact with the surface 81 of the mold 80, but when it is desired to form a composition obtained by drying the first raw material liquid 91 on the surface 102 of the molded body 100, the blade 31 is moved to the surface of the mold 80. In some cases, the surface 81 is not contacted. In FIG. 5, it is described that the circle indicating the first raw material liquid 91 is simply expanded by the blade 31, but these circles are formed in a plurality of recesses in a region surrounded by the circle. The raw material liquid 91 is filled, and a state in which the first raw material liquid 91 does not remain on the surface around the recess is schematically shown.
(D) In order to fill the first raw material liquid 91, the blade holding mechanism 33 is moved horizontally by a predetermined distance horizontally as described in (c), and then the blade 31 is moved upward so as to be separated from the surface of the mold 80. Move to. After separating the blade 31 from the mold 80, the blade gripping mechanism 33 is moved above the collection box 36.
(4-5)取外し機構35
 取外し機構35には、例えば半球状をしたゴム製の2つの吸着盤35aを備えている。これら吸着盤35aは、内部を真空状態にすることによりブレード31の表面に吸着することができるように構成されている。ところで、取外し機構35は、回収ボックス36の真上に位置するブレード31に2つの吸着盤32aの位置を合わせる機能を備えている。取外し機構35は、これらの吸着盤35aによってブレード31表面を真空吸着して、移動機構34と協働して、ブレード把持機構33からブレード31を下方に向かって引き抜く。取外し機構35は、吸着盤35aでの吸着を止めて、引き抜いたブレード31を回収ボックス36の中に入れる。
(4-5) Removal mechanism 35
The removal mechanism 35 includes two suction discs 35a made of rubber, for example, hemispherical. These suction plates 35a are configured to be able to be sucked onto the surface of the blade 31 by making the inside a vacuum state. By the way, the removal mechanism 35 has a function of aligning the positions of the two suction disks 32a with the blade 31 positioned directly above the collection box 36. The removal mechanism 35 vacuum-sucks the surface of the blade 31 with these suction plates 35a and pulls the blade 31 downward from the blade gripping mechanism 33 in cooperation with the moving mechanism 34. The removal mechanism 35 stops the suction by the suction disk 35 a and puts the extracted blade 31 into the collection box 36.
(4-6)充填部23への型80の供給
 充填部23の前段には、第1のディスペンサ22が配置されている。ベルトコンベア21は、間欠的に動作する。ベルトコンベア21が停止しているときに型供給用マガジン20(図1参照)からベルトコンベア21に置かれた型80は、次のベルトコンベア21の動作時に運ばれてきて第1のディスペンサ22のディスペンス位置P1にセットされる。 ベルトコンベア21が停止して型80がディスペンス位置P1にあるときに、型80の表面に対して第1のディスペンサ22による吐出が行われる。この型80は、一度に4個の成形体100(図2参照)が成形できるように構成されている。従って、第1のディスペンサ22のヘッド22aを移動させることによって、一つの型80の表面の4箇所に第1の原料液91が吐出される。
 第1のディスペンサ22による吐出が完了すると、ベルトコンベア21が動作して、型80がディスペンス位置P1から充填位置P2に運ばれる。このとき並行して、取外し機構35によって第1の原料液91が付着したブレード31が取り外され、取付機構32によって新しいブレード31がブレード把持機構33に取り付けられ、ブレード31の交換が行なわれる(ステップS3-1)。
 ベルトコンベア21が停止して型80が充填位置P2にあるときに、ブレード把持機構33が移動機構34によって型80に沿って移動されて第1の原料液91が充填される(ステップS3-2)。
 第1の原料液91が充填された型80は、次にベルトコンベア21が動作したときに、充填位置P2から第1の乾燥用マガジン24の方に向けて搬送される。
(4-6) Supply of Mold 80 to Filling Unit 23 The first dispenser 22 is arranged in the front stage of the filling unit 23. The belt conveyor 21 operates intermittently. When the belt conveyor 21 is stopped, the mold 80 placed on the belt conveyor 21 from the mold supply magazine 20 (see FIG. 1) is transported during the next operation of the belt conveyor 21 and is stored in the first dispenser 22. Set to dispense position P1. When the belt conveyor 21 stops and the die 80 is at the dispensing position P1, the first dispenser 22 discharges the surface of the die 80. The mold 80 is configured such that four molded bodies 100 (see FIG. 2) can be molded at a time. Accordingly, by moving the head 22 a of the first dispenser 22, the first raw material liquid 91 is discharged to four locations on the surface of one mold 80.
When the discharge by the first dispenser 22 is completed, the belt conveyor 21 is operated, and the mold 80 is carried from the dispensing position P1 to the filling position P2. At the same time, the blade 31 to which the first raw material liquid 91 is attached is removed by the removal mechanism 35, the new blade 31 is attached to the blade gripping mechanism 33 by the attachment mechanism 32, and the blade 31 is exchanged (step). S3-1).
When the belt conveyor 21 is stopped and the mold 80 is at the filling position P2, the blade gripping mechanism 33 is moved along the mold 80 by the moving mechanism 34 to fill the first raw material liquid 91 (step S3-2). ).
The mold 80 filled with the first raw material liquid 91 is transported from the filling position P2 toward the first drying magazine 24 when the belt conveyor 21 is operated next time.
(5)第1の乾燥用マガジン24及び第2の乾燥用マガジン28
 第1の乾燥用マガジン24は、型80の複数の凹部82に充填された第1の原料液91(図6(c)参照)を乾燥させるための乾燥装置である。また、第2の乾燥用マガジン28は、型80の表面81に塗布された第2の原料液92及び複数の凹部82に充填された第2の原料液92(図7(c)参照)を乾燥させるための乾燥装置である。第1の乾燥用マガジン24及び第2の乾燥用マガジン28には、例えば型80を50個ずつストックすることができる。例えばファン(図示せず)によって型80と型80の間に設けられている隙間に送風され、第1の乾燥用マガジン24にストックされている期間中に凹部82の第1の原料液91が十分に乾燥され、第2の乾燥用マガジン28にストックされている期間中に凹部82の第2の原料液92が十分に乾燥される。
(5) First drying magazine 24 and second drying magazine 28
The first drying magazine 24 is a drying device for drying the first raw material liquid 91 (see FIG. 6C) filled in the plurality of concave portions 82 of the mold 80. Further, the second drying magazine 28 uses the second raw material liquid 92 applied to the surface 81 of the mold 80 and the second raw material liquid 92 filled in the plurality of recesses 82 (see FIG. 7C). It is a drying device for drying. For example, 50 molds 80 can be stocked in the first drying magazine 24 and the second drying magazine 28. For example, the first raw material liquid 91 in the recess 82 is blown into a gap provided between the molds 80 by a fan (not shown) and stocked in the first drying magazine 24. The second raw material liquid 92 in the recess 82 is sufficiently dried during the period of being sufficiently dried and stocked in the second drying magazine 28.
(6)第2のディスペンサ25
 図7(a)に示されているように、第1の乾燥用マガジン24で、複数の凹部82内の第1の原料液91の乾燥された型80の表面81に第2の原料液92が吐出される。例えば、複数の凹部82が形成されている領域の中心部に目掛けて第2の原料液92が吐出される。吐出された第2の原料液92は、型80の表面81の上に短時間で広がり、表面81に膜92aをつくる。
(6) Second dispenser 25
7A, in the first drying magazine 24, the second raw material liquid 92 is applied to the surface 81 of the dried mold 80 of the first raw material liquid 91 in the plurality of recesses 82. As shown in FIG. Is discharged. For example, the second raw material liquid 92 is discharged toward the center of the region where the plurality of recesses 82 are formed. The discharged second raw material liquid 92 spreads on the surface 81 of the mold 80 in a short time, and forms a film 92 a on the surface 81.
(7)基板加圧実装装置26
 図7(b)に示されているように、基板加圧実装装置26は、例えば基板101を掴むフィンガ26aを先端に有する多関節のロボットアームで構成される。フィンガ26aは、基板101の上部を掴み、基板101が第2の原料液92に押し付けられたときに第2の原料液92がフィンガ26aに付着しないようになっている。図6(c)と図7(a)とを比較すると、凹部82の中の第1の原料液91が乾燥すると、体積が小さくなって突起103の先端部分104の上面は表面81よりも下にある。つまり、凹部82の先端部分104の上に空間ができる。第2の原料液92は、基板101によって加圧されることで、先端部分104の上にできた凹部82の空間内にまで侵入する。この工程は、図4に示されている基板アセンブリ工程(ステップS7)である。なお、図7(b)の太い矢印は、基板101によって第2の原料液92に掛かっている圧力の方向を示している。
(7) Substrate pressure mounting device 26
As shown in FIG. 7B, the board pressurizing and mounting apparatus 26 is composed of, for example, an articulated robot arm having a finger 26a for gripping the board 101 at the tip. The finger 26a grips the upper part of the substrate 101, and the second raw material liquid 92 does not adhere to the finger 26a when the substrate 101 is pressed against the second raw material liquid 92. Comparing FIG. 6C and FIG. 7A, when the first raw material liquid 91 in the recess 82 is dried, the volume is reduced and the upper surface of the tip portion 104 of the protrusion 103 is lower than the surface 81. It is in. That is, a space is formed on the tip portion 104 of the recess 82. The second raw material liquid 92 enters the space of the recess 82 formed on the tip portion 104 by being pressurized by the substrate 101. This step is a substrate assembly step (step S7) shown in FIG. Note that the thick arrow in FIG. 7B indicates the direction of pressure applied to the second raw material liquid 92 by the substrate 101.
(8)特徴
 上述の成形体の製造装置10の第1のディスペンサ22は、第1の供給工程(ステップS2)において、複数の凹部82の形成されている型80の表面81に第1の原料液91を供給する第1の供給装置の一例である。上述の成形体100に形成されている複数の突起103が複数の凸部の一例であり、第1の原料液91によって突起103の先端部分104が形成される。次の工程は、乾燥装置である第1の乾燥用マガジン24により、複数の凹部82の第1の原料液91が乾燥される乾燥工程(ステップS4)である。
 上述の第2のディスペンサ25は、第1の乾燥用マガジン24で第1の原料液91の乾燥された型80の表面81に第2の原料液92を供給する第2の供給装置の一例である。第2の原料液92によって突起103の基台部分105及び積層膜106が形成される。このように、第1の原料液91とは異なる第2の原料液92を使うことで、突起103内の場所(先端部分104と基台部分105)によって組成が異なる成形体100の製造が容易になる。
 なお、上記実施形態では、凸部である突起103が円錐状の形状をしているが、凸部の形状は円錐以外の形状であってもよく、例えば角錐、円柱、角柱及びドーム型であってもよい。
(8) Features The first dispenser 22 of the above-described molded body manufacturing apparatus 10 has a first raw material on the surface 81 of the mold 80 in which a plurality of recesses 82 are formed in the first supply step (step S2). It is an example of the 1st supply apparatus which supplies the liquid 91. FIG. The plurality of protrusions 103 formed on the molded body 100 described above is an example of a plurality of protrusions, and the tip portion 104 of the protrusion 103 is formed by the first raw material liquid 91. The next step is a drying step (step S4) in which the first raw material liquid 91 in the plurality of recesses 82 is dried by the first drying magazine 24 that is a drying device.
The second dispenser 25 described above is an example of a second supply device that supplies the second raw material liquid 92 to the surface 81 of the mold 80 dried with the first raw material liquid 91 by the first drying magazine 24. is there. The base portion 105 and the laminated film 106 of the protrusion 103 are formed by the second raw material liquid 92. As described above, by using the second raw material liquid 92 different from the first raw material liquid 91, it is easy to manufacture the molded body 100 having a different composition depending on the location in the protrusion 103 (the tip portion 104 and the base portion 105). become.
In the above embodiment, the protrusion 103 which is a convex portion has a conical shape, but the shape of the convex portion may be a shape other than a cone, for example, a pyramid, a cylinder, a prism, and a dome shape. May be.
 ブレード把持機構33は、スリット33aにブレード31を嵌めこんだり、スリット33aからブレード31を引き抜いたりできるように構成されており、ブレード31を着脱自在に把持することができる。
 移動機構34は、ブレード把持機構33に把持されているブレード31によって第1の原料液91が複数の凹部82に充填されるようにブレード把持機構33を型80の表面81に沿って相対的に移動させることができるように構成されている。上記の例では、ベルトコンベア21の上に型80が水平に載置されているので、第1の原料液91を複数の凹部82に充填するためにブレード把持機構33は水平に移動される。また、ブレード把持機構33が水平に移動される際、ブレード31と型80の表面81とのなす角が鋭角(0<θ<90)であるための第1の原料液91が凹部82の中に充填され易くなっている。
 上記実施形態では、ブレードストッカ30と取付機構32と取外し機構35と回収ボックス36がブレード交換機構40を構成している。取付機構32がブレード31をブレードストッカ30からブレード把持機構33まで搬送して取り付け、取外し機構35がブレード31をブレード把持機構33から取り外して回収ボックス36に入れることで、ブレード交換機構40は、第1の原料液91が充填される動作の前に、第1の原料液91が付着したブレード31を取り外し、第1の原料液91の付着していないブレード31を取り付けることができる。
 これを製造方法の面から見ると、充填工程(ステップS3-2)でブレード把持機構33が移動されて型80の複数の凹部82に第1の原料液91が充填される動作の前に、ブレード交換工程(ステップS3-1)によって、ブレード把持機構33には、第1の原料液91が付着したブレード31に換えて第1の原料液91の付着していない新たなブレード31が取り付けられる。
The blade gripping mechanism 33 is configured such that the blade 31 can be fitted into the slit 33a and the blade 31 can be pulled out from the slit 33a, and the blade 31 can be detachably gripped.
The moving mechanism 34 moves the blade holding mechanism 33 relatively along the surface 81 of the mold 80 so that the first raw material liquid 91 is filled into the plurality of recesses 82 by the blade 31 held by the blade holding mechanism 33. It is configured so that it can be moved. In the above example, since the mold 80 is placed horizontally on the belt conveyor 21, the blade gripping mechanism 33 is moved horizontally in order to fill the plurality of concave portions 82 with the first raw material liquid 91. In addition, when the blade gripping mechanism 33 is moved horizontally, the first raw material liquid 91 because the angle between the blade 31 and the surface 81 of the mold 80 is an acute angle (0 <θ <90) is contained in the recess 82. It is easy to be filled.
In the above embodiment, the blade stocker 30, the attachment mechanism 32, the removal mechanism 35, and the collection box 36 constitute the blade replacement mechanism 40. The attachment mechanism 32 transports and attaches the blade 31 from the blade stocker 30 to the blade gripping mechanism 33, and the removal mechanism 35 removes the blade 31 from the blade gripping mechanism 33 and puts it in the collection box 36. Before the operation of filling one raw material liquid 91, the blade 31 to which the first raw material liquid 91 is attached can be removed, and the blade 31 to which the first raw material liquid 91 is not attached can be attached.
From the viewpoint of the manufacturing method, before the operation of moving the blade gripping mechanism 33 in the filling step (step S3-2) and filling the plurality of concave portions 82 of the mold 80 with the first raw material liquid 91, Through the blade replacement process (step S3-1), a new blade 31 to which the first raw material liquid 91 is not attached is attached to the blade gripping mechanism 33 in place of the blade 31 to which the first raw material liquid 91 is attached. .
 その結果、第1の原料液91が付着していない衛生的なブレード31を常に使用して型80の凹部82に第1の原料液91を充填するような製造が可能になる。成形体の製造装置10又は図4に示した成形体の製造方法では、アイソレータ11の内部において、複数の突起103を持つ成形体100の製造につき、高い衛生状態が確保し易くなる。
 また、第1の原料液91が付着していない衛生的なブレード31をブレードストッカ30から取付機構32でブレード把持機構33まで自動的に搬送してブレード把持機構33に自動的に取り付けられるので、ブレード31を取り付けるためのアイソレータ11の内部における作業に作業者を立ち入らせないことで衛生面の向上を図ることができる。
 また、取外し機構35によって自動的に第1の原料液91が付着したブレードを取り外すことができ、ブレード31を取り外すためのアイソレータ11の内部における作業に作業者を立ち入らせないことで衛生面の向上を図ることができる。
As a result, the sanitary blade 31 to which the first raw material liquid 91 is not attached is always used to manufacture the concave portion 82 of the mold 80 with the first raw material liquid 91. In the molded body manufacturing apparatus 10 or the molded body manufacturing method shown in FIG. 4, it is easy to ensure a high sanitary condition for manufacturing the molded body 100 having the plurality of protrusions 103 inside the isolator 11.
Further, the sanitary blade 31 to which the first raw material liquid 91 is not attached is automatically conveyed from the blade stocker 30 to the blade gripping mechanism 33 by the mounting mechanism 32 and automatically attached to the blade gripping mechanism 33. Hygiene can be improved by not allowing the operator to enter the work inside the isolator 11 for attaching the blade 31.
Further, the blade to which the first raw material liquid 91 is attached can be automatically removed by the removing mechanism 35, and the hygiene is improved by preventing the worker from entering the work inside the isolator 11 for removing the blade 31. Can be achieved.
(9)変形例
 以上、本発明の一実施形態について説明したが、本発明は上記実施形態に限定されるものではなく、発明の要旨を逸脱しない範囲で種々の変更が可能である。特に、本明細書に書かれた実施形態及び変形例は必要に応じて任意に組み合せ可能である。
(9-1)
 上記の実施形態では、第1の原料液91と第2の原料液92を用いて凸部の一例である突起103を形成する場合について説明したが、第1の原料液91だけで凸部を形成してもよい。第1の原料液91だけで凸部を形成する場合には、第2のディスペンサ25による第2の供給工程(ステップS6)の前後の工程(ステップS5,S7,S8)が省かれる。また、ブレード31で第1の原料液91を型80に塗布する際には、乾燥後に型80の表面81に積層膜が形成されるように、ブレード31と表面81との間に隙間が設けられる。
(9) Modifications Although one embodiment of the present invention has been described above, the present invention is not limited to the above embodiment, and various modifications can be made without departing from the scope of the invention. In particular, the embodiments and modifications described in the present specification can be arbitrarily combined as necessary.
(9-1)
In the above embodiment, the case where the protrusion 103 which is an example of the convex portion is formed using the first raw material liquid 91 and the second raw material liquid 92 has been described, but the convex portion is formed only by the first raw material liquid 91. It may be formed. When forming a convex part only with the 1st raw material liquid 91, the process (step S5, S7, S8) before and behind the 2nd supply process (step S6) by the 2nd dispenser 25 is omitted. In addition, when the first raw material liquid 91 is applied to the mold 80 with the blade 31, a gap is provided between the blade 31 and the surface 81 so that a laminated film is formed on the surface 81 of the mold 80 after drying. It is done.
(9-2)
 上記の実施形態では、第1の原料液91と第2の原料液92を用いて凸部の一例である突起103を形成する場合について説明したが、第3の原料液を追加して凸部を形成してもよい。先端部分104と基台部分105との間に第3の原料液を追加して他の層を設ける場合には、例えば、第3の原料液を充填するために、第1のディスペンサ22による第1の供給工程(ステップS2)~乾燥工程(ステップS4)と同様の工程が追加される。
(9-2)
In the above embodiment, the case where the protrusion 103 which is an example of the convex portion is formed using the first raw material liquid 91 and the second raw material liquid 92 has been described, but the third raw material liquid is added to the convex portion. May be formed. In the case where another layer is provided by adding the third raw material liquid between the tip portion 104 and the base portion 105, for example, the first dispenser 22 is used to fill the third raw material liquid. Processes similar to the supply process (step S2) to the drying process (step S4) are added.
(9-3)
 上記実施形態では、移動機構34及び基板加圧実装装置26を汎用的なロボットアームを用いて構成する場合について説明したが、例えば、ロボットアーム以外の機器を用いて専用の装置として構成することができる。
(9-3)
In the above-described embodiment, the case where the moving mechanism 34 and the substrate pressurizing and mounting apparatus 26 are configured using a general-purpose robot arm has been described. it can.
10 成形体の製造装置
11 アイソレータ
22 第1のディスペンサ
23 充填部
24 第1の乾燥用マガジン
25 第2のディスペンサ
26 基板加圧実装装置
30 ブレードストッカ
31 ブレード
32 取付機構
33 ブレード把持機構
34 移動機構
35 取外し機構
36 回収ボックス
40 ブレード交換機構
80 型
91 第1の原料液
92 第2の原料液
100 成形体
101 基体
103 突起
104 先端部分
105 基台部分
S2 第1の供給工程
S3-1 ブレード交換工程
S3-2 充填工程
S4 乾燥工程
S6 第2の供給工程
DESCRIPTION OF SYMBOLS 10 Molded body manufacturing apparatus 11 Isolator 22 First dispenser 23 Filling portion 24 First drying magazine 25 Second dispenser 26 Substrate pressure mounting apparatus 30 Blade stocker 31 Blade 32 Mounting mechanism 33 Blade gripping mechanism 34 Moving mechanism 35 Removal mechanism 36 Recovery box 40 Blade replacement mechanism 80 Mold 91 First raw material liquid 92 Second raw material liquid 100 Molded body 101 Base 103 Projection 104 Tip portion 105 Base portion S2 First supply step S3-1 Blade replacement step S3 -2 Filling step S4 Drying step S6 Second supply step

Claims (6)

  1.  複数の凸部を持つ成形体を成形するための第1の原料液を、複数の凹部が表面に形成されている型の表面に供給する第1の供給装置と、
     ブレードを着脱自在に把持するブレード把持機構と、
     前記ブレード把持機構に把持されている前記ブレードによって前記第1の原料液が複数の前記凹部に充填されるように前記ブレード把持機構を前記型の前記表面に沿って相対的に移動させる移動機構と、
     前記移動機構によって前記ブレード把持機構を移動させて複数の前記凹部に前記第1の原料液を充填する前に、前記ブレード把持機構から前記第1の原料液が付着した前記ブレードを取り外し、前記ブレード把持機構に前記第1の原料液の付着していない前記ブレードを取り付けるブレード交換機構と
    を備える、成形体の製造装置。
    A first supply device for supplying a first raw material liquid for forming a molded body having a plurality of convex portions to the surface of a mold having a plurality of concave portions formed on the surface;
    A blade gripping mechanism for detachably gripping the blade;
    A moving mechanism for relatively moving the blade gripping mechanism along the surface of the mold so that the plurality of recesses are filled with the first raw material liquid by the blade gripped by the blade gripping mechanism; ,
    Before the blade holding mechanism is moved by the moving mechanism to fill the plurality of recesses with the first raw material liquid, the blade to which the first raw material liquid is attached is removed from the blade holding mechanism, and the blade An apparatus for manufacturing a molded body, comprising: a blade replacement mechanism that attaches the blade to which the first raw material liquid is not attached to a gripping mechanism.
  2.  前記ブレード交換機構は、複数の前記ブレードをストックするブレードストッカと、前記ブレードを前記ブレードストッカから前記ブレード把持機構まで搬送して取り付ける取付機構とを有する、
    請求項1に記載の成形体の製造装置。
    The blade replacement mechanism includes a blade stocker that stocks a plurality of the blades, and an attachment mechanism that transports and attaches the blade from the blade stocker to the blade gripping mechanism.
    The manufacturing apparatus of the molded object of Claim 1.
  3.  前記ブレード交換機構は、前記ブレード把持機構から前記第1の原料液が付着した前記ブレードを取り外す取外し機構をさらに有する、
    請求項2に記載の成形体の製造装置。
    The blade replacement mechanism further includes a removal mechanism for removing the blade to which the first raw material liquid has adhered from the blade gripping mechanism.
    The manufacturing apparatus of the molded object of Claim 2.
  4.  前記型の複数の前記凹部に充填された前記第1の原料液を乾燥させる乾燥装置と、
     前記乾燥装置で複数の前記凹部の前記第1の原料液が乾燥された前記型の前記表面に第2の原料液を供給する第2の供給装置と
    をさらに備える、
    請求項1から3のいずれか一項に記載の成形体の製造装置。
    A drying device for drying the first raw material liquid filled in the plurality of concave portions of the mold;
    A second supply device for supplying a second raw material liquid to the surface of the mold in which the first raw material liquid in the plurality of recesses is dried by the drying device;
    The manufacturing apparatus of the molded object as described in any one of Claim 1 to 3.
  5.  複数の凸部を持つ成形体を成形するための第1の原料液を、複数の凹部が表面に形成されている型の表面に供給する第1の供給工程と、
     ブレード把持機構に把持されているブレードを前記型の前記表面に沿って相対的に移動させて、前記ブレードによって前記型の複数の凹部に前記第1の原料液を充填する充填工程と、
     前記充填工程の前に、前記第1の原料液が付着した前記ブレードを前記ブレード把持機構から取り外し、前記第1の原料液の付着していない前記ブレードを前記ブレード把持機構に取り付けるブレード交換工程と
    を備える、成形体の製造方法。
    A first supply step of supplying a first raw material liquid for forming a molded body having a plurality of convex portions to the surface of a mold having a plurality of concave portions formed on the surface;
    A filling step of relatively moving the blade held by the blade holding mechanism along the surface of the mold and filling the plurality of concave portions of the mold with the first raw material liquid by the blade;
    Before the filling step, a blade exchanging step of removing the blade having the first raw material liquid attached thereto from the blade gripping mechanism and attaching the blade not having the first raw material liquid attached to the blade gripping mechanism; The manufacturing method of a molded object provided with.
  6.  前記型の複数の前記凹部に充填された前記第1の原料液を乾燥させる乾燥工程と、
     前記乾燥工程で複数の前記凹部の前記第1の原料液が乾燥された前記型の前記表面に第2の原料液を供給する第2の供給工程と
    をさらに備える、
    請求項5に記載の成形体の製造方法。
     
    A drying step of drying the first raw material liquid filled in the plurality of concave portions of the mold;
    A second supply step of supplying a second raw material liquid to the surface of the mold in which the first raw material liquid of the plurality of recesses is dried in the drying step;
    The manufacturing method of the molded object of Claim 5.
PCT/JP2015/075552 2014-09-29 2015-09-09 Molded-article production device and molded-article production method WO2016052108A1 (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019146277A1 (en) * 2018-01-25 2019-08-01 富士フイルム株式会社 Transdermal absorption sheet production method

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0531945U (en) * 1991-10-03 1993-04-27 ナビタス株式会社 Pad printing machine
JP2008520433A (en) * 2004-11-18 2008-06-19 スリーエム イノベイティブ プロパティズ カンパニー Contact coating method of microneedle array
JP2009269132A (en) * 2008-05-08 2009-11-19 Disco Abrasive Syst Ltd Blade attaching and detaching auxiliary device
JP2012055343A (en) * 2010-09-03 2012-03-22 Toray Eng Co Ltd Microneedle sheet and method for manufacturing the same
JP2012201103A (en) * 2011-03-28 2012-10-22 Toray Eng Co Ltd Apparatus and method of printing and filling

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0531945U (en) * 1991-10-03 1993-04-27 ナビタス株式会社 Pad printing machine
JP2008520433A (en) * 2004-11-18 2008-06-19 スリーエム イノベイティブ プロパティズ カンパニー Contact coating method of microneedle array
JP2009269132A (en) * 2008-05-08 2009-11-19 Disco Abrasive Syst Ltd Blade attaching and detaching auxiliary device
JP2012055343A (en) * 2010-09-03 2012-03-22 Toray Eng Co Ltd Microneedle sheet and method for manufacturing the same
JP2012201103A (en) * 2011-03-28 2012-10-22 Toray Eng Co Ltd Apparatus and method of printing and filling

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019146277A1 (en) * 2018-01-25 2019-08-01 富士フイルム株式会社 Transdermal absorption sheet production method

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