WO2016001293A1 - Injection device with compression spring for engaging ratchet elements, for biasing an actuation button, and for biasing a locking element into a dose setting mode - Google Patents
Injection device with compression spring for engaging ratchet elements, for biasing an actuation button, and for biasing a locking element into a dose setting mode Download PDFInfo
- Publication number
- WO2016001293A1 WO2016001293A1 PCT/EP2015/064967 EP2015064967W WO2016001293A1 WO 2016001293 A1 WO2016001293 A1 WO 2016001293A1 EP 2015064967 W EP2015064967 W EP 2015064967W WO 2016001293 A1 WO2016001293 A1 WO 2016001293A1
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- WO
- WIPO (PCT)
- Prior art keywords
- dose
- housing
- injection device
- dose setting
- locking element
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/3157—Means providing feedback signals when administration is completed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2026—Semi-automatic, e.g. user activated piston is assisted by additional source of energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3125—Details specific display means, e.g. to indicate dose setting
- A61M2005/3126—Specific display means related to dosing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
Definitions
- the present invention is generally directed to an injection device, i.e. a drug delivery device for selecting and dispensing a number of user variable doses of a medicament.
- Pen type drug delivery devices have application where regular injection by persons without formal medical training occurs. This may be increasingly common among patients having diabetes where self-treatment enables such patients to conduct effective management of their disease.
- a drug delivery device allows a user to individually select and dispense a number of user variable doses of a medicament.
- the present invention is not directed to so called fixed dose devices which only allow dispensing of a predefined dose without the possibility to increase or decrease the set dose.
- resettable devices i.e., reusable
- non-resettable i.e., disposable
- disposable pen delivery devices are supplied as self-contained devices.
- Such self-contained devices do not have removable pre-filled cartridges. Rather, the pre-filled cartridges may not be removed and replaced from these devices without destroying the device itself. Consequently, such disposable devices need not have a resettable dose setting mechanism.
- the present invention is applicable for both types of devices, i.e. for disposable devices as well as for reusable devices.
- a further differentiation of drug delivery device types refers to the drive mechanism: There are devices which are manually driven, e.g. by a user applying a force to an injection button, devices which are driven by a spring or the like and devices which combine these two concepts, i.e. spring assisted devices which still require a user to exert an injection force.
- the spring-type devices involve springs which are preloaded and springs which are loaded by the user during dose selecting. Some stored-energy devices use a combination of spring preload and additional energy provided by the user, for example during dose setting.
- Unpublished application EP 13 163 089.9 describes an injection device for setting and dispensing a number of user variable doses of a medicament.
- the device comprises a housing, a drive member, a locking element, a first clutch and an actuation button.
- the housing defines a longitudinal axis.
- the drive member is rotationally constrained to the housing in a first dose setting mode and is rotatable relative to the housing in a second dose dispensing mode.
- the locking element is permanently rotationally constrained to the housing but axially movable relative to the housing in a direction parallel to the longitudinal axis between a first dose setting position and a second dose dispensing position.
- the first clutch rotationally couples the drive member to the locking element when the locking element is in its first dose setting position and de-couples the drive member and the locking element when the locking element is in its second dose dispensing position.
- the actuation button is suitable for switching the injection device between the first dose setting mode and the second dose dispensing mode.
- the actuation button and the locking element are separate components which are not attached to each other. However, the actuation button axially abuts the locking element such that an axial force may be transmitted from the actuation button to the locking element in one direction.
- a first compression spring acts on the actuation button biasing the actuation button in its dose setting mode position. This first compression spring further acts on a ratchet between the driver and a dose indicator or dose setting member.
- a second compression spring acts on the locking element biasing the locking element in its dose setting position. It is an object of the present invention to improve this known device with respect to manufacturing costs, complexity of assembly and reliability.
- a device as defined in claim 1 with the spring biasing the locking element and the actuation button into their first dose setting position and in addition biasing the first ratchet features into engagement with the second ratchet features.
- one single spring preferably a compression spring
- the same spring may be used to keep two ratchet elements into engaging contact, which facilitates dose setting and dose dispensing.
- one component required in the device of unpublished application EP 13 163 089.9 namely an additional compression spring, can be omitted which does not only reduce the costs for the components of the device but also reduces the time and effort required during assembly of the device.
- the spring biasing the locking element this is understood to encompass the preferred embodiment wherein the locking element is axially constrained to the button and the spring biases the button, effectively biasing the locking element.
- the actuation button is axially constrained and rotatable relative to the locking element.
- the actuation button may be snapped or clipped onto the locking element.
- This axial constraint results in the actuation button and the locking element behaving as one single component regarding their axial movements.
- Advantages of this design include that there is no need for a spring to push the locking arm in the proximal direction during dialling and ease of assembly because the button and the locking arm can be assembled together.
- the actuation button is preferably provided with a central stem extending from a proximal actuation area. A bead or flange may be provided on this stem with the compression spring abutting this bead or flange.
- the compression spring may be arranged such that it acts on the locking element which in turn entrains the actuation button.
- the locking element comprises an arm portion extending parallel to the longitudinal axis between the housing and the drive member.
- a first clutch may be provided at one end of the arm portion and the actuation button may be attached to the opposite end of the arm portion.
- the ratchet permits the dose setting member to rotate during dose setting without affecting the driver, but ensures that the driver is moved together with the dose setting member during dose dispensing. In addition to dose setting and dose dispensing it may be required to correct a dose, i.e. to decrease the set dose.
- the first ratchet features and the second ratchet features comprise teeth having ramp angles allowing overhaul of the ratchet for dose correction.
- the ratchet typically has to withstand this torque or force, which is a function of the axial load applied by the spring, the ramp angle of the ratchet, the friction coefficient between the mating surfaces and the mean radius of the ratchet features and the torque applied by the torsion spring. It may be desirable to choose different ramp angles for clockwise and anti-clockwise relative rotation of the ratchet features so that the spring torque cannot overhaul the ratchet whilst ensuring the dial-up torque is as low as possible.
- the position of the gauge element may thus be used to identify the actually set and/or dispensed dose. Different colours of sections of the gauge member may facilitate identifying the set and/or dispensed dose without reading numbers, symbols or the like on a display.
- rotation of the dose indicator causes an axial displacement of the gauge element relative to the dose indicator and relative to the housing.
- the gauge element may have the form of a shield or strip extending in the longitudinal direction of the device.
- the gauge element may be a sleeve.
- the dose indicator is marked with a sequence of numbers or symbols and the gauge element comprises an aperture or window.
- the injection device further comprises a resilient member adapted to provide a force necessary for ejecting a dose from the injection device.
- a resilient member such as a spring, generating the force or torque required for dose dispensing reduces the user applied forces for dose dispensing. This is especially helpful for users with impaired dexterity.
- the dial extension of the known manually driven devices which is a result of the required dispensing stroke, may be omitted by providing the resilient member because merely a small triggering stroke may be necessary for releasing the resilient member.
- the concept of the gauge element and the dose indicator is applicable for various types of devices with or without a drive spring.
- the resilient member may be a spring which is preloaded or a spring which is loaded by the user during dose selecting. This includes devices which use a combination of spring preload and additional energy provided by the user, for example during dose setting.
- the resilient member may be a torsion spring which is preferably strained during dose setting. The torsion spring may have one end attached to the housing and the other end attached to the dose indicator.
- the injection device comprises a lead screw or piston rod, which is driven by the drive member during dose dispensing to act on a cartridge bung. If the lead screw rotates during dose dispensing, friction occurs with respect to the (rotationally static) cartridge bung.
- a bearing may be provided to minimize friction.
- the lead screw is provided at its distal end with an interface for clip attachment of the bearing, wherein the bearing has a convex contact surface and the lead screw has a concave contact surface. The curvature of the convex contact surface and the concave contact surface may be chosen such that the contact diameter between the bearing and lead screw is small, to minimize the frictional losses at this interface.
- the dose indicator and/or a dial sleeve rotate during dose setting and during dose dispensing, whereas the drive member only rotates during dose dispensing together with the dose indicator and/or the dial sleeve.
- the nut member will only move axially during dose setting and will remain stationary with respect to these components during dose dispensing.
- the nut member is threaded to the drive member and splined to the dose indicator and/or the dial sleeve.
- the nut member may be threaded to the dose indicator and/or the dial sleeve and may be splined to the drive member.
- the nut member may be a full nut or a part thereof, e.g. a half nut.
- the injection device may comprise at least one clicker mechanism for generating a tactile and/or audible feedback.
- a tactile feedback during dose dispense may be provided via a compliant cantilever clicker arm integrated into the proximal end of the locking element. This clicker arm may interface radially with ratchet features (e.g.
- the ratchet features engage with the clicker arm to produce an audible click with each dose increment delivered.
- the clicker mechanism signifies the end of dose dispensing.
- an audible feedback may be provided in the form of a "click", distinct from the "clicks" provided during dispense, to inform the user that the device has returned to its zero position.
- the term arrivingmedicament means a pharmaceutical formulation containing at least one pharmaceutically active compound, wherein in one embodiment the pharmaceutically active compound has a molecular weight up to 1500 Da and/or is a peptide, a proteine, a polysaccharide, a vaccine, a DNA, a RNA, an enzyme, an antibody or a fragment thereof, a hormone or an oligonucleotide, or a mixture of the above-mentioned pharmaceutically active compound, wherein in a further embodiment the pharmaceutically active compound is useful for the treatment and/or prophylaxis of diabetes mellitus or complications associated with diabetes mellitus such as diabetic retinopathy, thromboembolism disorders such as deep vein or pulmonary thromboembolism, acute coronary syndrome (ACS), angina, myocardial infarction, cancer, macular degeneration, inflammation, hay fever, atherosclerosis and/or rheumatoid arthritis, wherein in a further embodiment the pharmaceutically active
- Insulin derivates are for example B29-N-myristoyl-des(B30) human insulin; B29-N-palmitoyl- des(B30) human insulin; B29-N-myristoyl human insulin; B29-N-palmitoyl human insulin; B28-N-myristoyl LysB28ProB29 human insulin; B28-N-palmitoyl-LysB28ProB29 human insulin; B30-N-myristoyl-ThrB29LysB30 human insulin; B30-N-palmitoyl- ThrB29LysB30 human insulin; B29-N-(N-palmitoyl-Y-glutamyl)-des(B30) human insulin; B29-N-(N- lithocholyl-Y-glutamyl)-des(B30) human insulin; B29-N-((jo-carboxyheptadecanoyl)-des(B30) human insulin and B29-N-(oo-
- Exendin-4 for example means Exendin-4(1 -39), a peptide of the sequence H-His-Gly-Glu- Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-lle-Glu- Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2.
- Hormones are for example hypophysis hormones or hypothalamus hormones or regulatory active peptides and their antagonists as listed in Rote Liste, ed.
- Gonadotropine Follitropin, Lutropin, Choriongonadotropin, Menotropin
- Somatropine Somatropin
- Desmopressin Terlipressin
- Gonadorelin Triptorelin
- Leuprorelin Buserelin
- Nafarelin Goserelin
- each antibody As they have sugar chains added to amino acid residues, they are glycoproteins.
- the basic functional unit of each antibody is an immunoglobulin (Ig) monomer (containing only one Ig unit); secreted antibodies can also be dimeric with two Ig units as with IgA, tetrameric with four Ig units like teleost fish IgM, or pentameric with five Ig units, like mammalian IgM.
- Ig immunoglobulin
- the Ig monomer is a "Y"-shaped molecule that consists of four polypeptide chains; two identical heavy chains and two identical light chains connected by disulfide bonds between cysteine residues. Each heavy chain is about 440 amino acids long; each light chain is about 220 amino acids long. Heavy and light chains each contain intrachain disulfide bonds which stabilize their folding. Each chain is composed of structural domains called Ig domains.
- domains contain about 70-1 10 amino acids and are classified into different categories (for example, variable or V, and constant or C) according to their size and function. They have a characteristic immunoglobulin fold in which two ⁇ sheets create a "sandwich" shape, held together by interactions between conserved cysteines and other charged amino acids.
- Ig heavy chain There are five types of mammalian Ig heavy chain denoted by ⁇ , ⁇ , ⁇ , ⁇ , and ⁇ .
- the type of heavy chain present defines the isotype of antibody; these chains are found in IgA, IgD, IgE, IgG, and IgM antibodies, respectively.
- Distinct heavy chains differ in size and composition; a and ⁇ contain approximately 450 amino acids and ⁇ approximately 500 amino acids, while ⁇ and ⁇ have approximately 550 amino acids.
- Each heavy chain has two regions, the constant region (CH) and the variable region (VH).
- the constant region is essentially identical in all antibodies of the same isotype, but differs in antibodies of different isotypes.
- Heavy chains ⁇ , a and ⁇ have a constant region composed of three tandem Ig domains, and a hinge region for added flexibility; heavy chains ⁇ and ⁇ have a constant region composed of four immunoglobulin domains.
- the variable region of the heavy chain differs in antibodies produced by different B cells, but is the same for all antibodies produced by a single B cell or B cell clone.
- the variable region of each heavy chain is approximately 1 10 amino acids long and is composed of a single Ig domain.
- a light chain has two successive domains: one constant domain (CL) and one variable domain (VL).
- CL constant domain
- VL variable domain
- the approximate length of a light chain is 21 1 to 217 amino acids.
- Each antibody contains two light chains that are always identical; only one type of light chain, ⁇ or ⁇ , is present per antibody in mammals.
- variable (V) regions are responsible for binding to the antigen, i.e. for its antigen specificity.
- VL variable light
- VH variable heavy chain
- CDRs Complementarity Determining Regions
- an "antibody fragment” contains at least one antigen binding fragment as defined above, and exhibits essentially the same function and specificity as the complete antibody of which the fragment is derived from.
- Limited proteolytic digestion with papain cleaves the Ig prototype into three fragments. Two identical amino terminal fragments, each containing one entire L chain and about half an H chain, are the antigen binding fragments (Fab).
- the Fc contains carbohydrates, complement-binding, and FcR-binding sites.
- F(ab')2 is divalent for antigen binding.
- the disulfide bond of F(ab')2 may be cleaved in order to obtain Fab'.
- the variable regions of the heavy and light chains can be fused together to form a single chain variable fragment (scFv).
- Pharmaceutically acceptable salts are for example acid addition salts and basic salts.
- Acid addition salts are e.g. HCI or HBr salts.
- Basic salts are e.g. salts having a cation selected from alkali or alkaline, e.g. Na+, or K+, or Ca2+, or an ammonium ion N+(R1 )(R2)(R3)(R4), wherein R1 to R4 independently of each other mean: hydrogen, an optionally substituted C1 -C6-alkyl group, an optionally substituted C2-C6-alkenyl group, an optionally substituted C6-C10-aryl group, or an optionally substituted C6-C10-heteroaryl group.
- R1 to R4 independently of each other mean: hydrogen, an optionally substituted C1 -C6-alkyl group, an optionally substituted C2-C6-alkenyl group, an optionally substituted C6-C10-aryl group,
- solvates are for example hydrates.
- FIG. 1 shows an exploded view of the components of an injection device in accordance with a first embodiment of the present invention
- FIG. 1 shows a sectional view of the device of Figure 1 ;
- FIG. 1 shows an enlarged view of a detail of the device of Figure 1 in the dose setting mode
- FIG. 1 shows an enlarged detail of the driver and the nut of the device of Figure 1 ; shows an enlarged detail of the button of the device of Figure 1 ;
- FIG. 1 shows an enlarged detail of the dose indicator of the device of Figure 1 ; shows an enlarged detail of the lead screw and bearing of the device of Figure 1 ;
- FIG. 1 shows an enlarged detail of the locking element of the device of Figure 1 ; shows an enlarged detail of the locking element and button of the device of Figure 1 ;
- the dose selector 80 or dose dial grip is a sleeve-like component with a serrated outer skirt.
- the dose selector 80 is axially constrained to the housing 10. It is rotationally constrained, via a splined interface, to the dose button 70. This splined interface which includes grooves 81 interacting with the spline features 75 remains engaged irrespective of the dose button 70 axial positions.
- the torsion spring 90 is attached with its distal end to the housing 10 and with its other end to the number sleeve lower 61 . The torsion spring 90 is pre-wound upon assembly, such that it applies a torque to the dose indicator 60 when the mechanism is at zero units dialled.
- the action of rotating the dose selector 80, to set a dose rotates the dose indicator 60 relative to the housing 10, and charges the torsion spring 90 further.
- the torsion spring 90 is located inside the dose indicator 60 and surrounds a distal portion of the driver 40. As shown in Figure 10, the spring has a hook 91 at one end for attachment on the dose indicator 60. A similar hook end may be provided at the opposite end for attachment on the housing.
- the clutch spring 130 is a compression spring located interposed between flange 72 of button 70 and clutch plate 120. It acts on the clutch plate 120 allowing the ratchet teeth 43, 121 to bump over each other during dose setting against the axial force of the spring.
- the axial position of the locking element 100, clutch plate 120 and button 70 is defined by the action of the clutch spring 130, which applies a force on the button 70 in the proximal direction. This force is reacted by the clutch plate, via the driver 40, to the housing 10 and ensures that the ratchet interface is always engaged. In the "at rest" position, this ensures that the button splines are engaged with the number sleeve upper 62, and the teeth 41 of driver 40 are engaged with the locking element 100 and that the ratchet interface is engaged.
- the bearing 140 is axially constrained to the lead screw 30 ( Figure 16) and acts on the bung within the liquid medicament cartridge 150. It is axially clipped to the lead screw 30, but free to rotate.
- the bearing 140 comprises a disc 141 having a stem 142 extending in the proximal direction.
- the stem 142 has at its proximal end a convex contact surface 143.
- a recessed portion 144 is provided on the stem 142.
- the curvature of the convex contact surface 143 and the concave contact surface 34 is chosen such that the contact diameter between the bearing 140 and lead screw 30 is small to minimize the frictional losses at this interface.
- the user may now choose to increase the selected dose by continuing to rotate the dose selector 80 in the clockwise direction.
- the process of overhauling the ratchet interfaces 43, 121 between the dose indicator 60 and driver 40 is repeated for each dose increment.
- the torque applied to the dose selector 80 by the user is sufficient, when combined with the torque applied by the torsion spring 90, to overhaul the ratchet 43, 121 between the clutch plate 120 and driver 40 in the anti-clockwise direction ( Figure 12).
- the ratchet is overhauled, anti-clockwise rotation occurs in the dose indicator 60 (via the clutch plate 120), which returns the dose indicator 60 towards the zero dose position, and unwinds the torsion spring 90.
- the relative rotation between the dose indicator 60 and driver 40 causes the last dose nut 50 to return along its helical path, away from the last dose stop 46 ( Figure 13).
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- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2015282975A AU2015282975A1 (en) | 2014-07-01 | 2015-07-01 | Injection device with compression spring for engaging ratchet elements, for biasing an actuation button, and for biasing a locking element into a dose setting mode |
CN201580030588.8A CN106535965A (en) | 2014-07-01 | 2015-07-01 | Injection device with compression spring for engaging ratchet elements, for biasing actuation button, and for biasing locking element into dose setting mode |
JP2017519984A JP2017520368A (en) | 2014-07-01 | 2015-07-01 | An injection device including a compression spring for engaging the ratchet element, urging the actuation button, and urging the locking element into the dose setting mode |
US15/321,870 US10420889B2 (en) | 2014-07-01 | 2015-07-01 | Injection device with compression spring for engaging ratchet elements, for biasing an actuation button, and for biasing a locking element into a dose setting mode |
RU2016152234A RU2016152234A (en) | 2014-07-01 | 2015-07-01 | COMPRESSION SPRING INJECTOR FOR CLUTCHING WITH RATCHET ELEMENTS, PURPOSE OF DISPLACING THE OPERATION BUTTON AND TO DISPLAY THE LOCKING ELEMENT IN THE POSITION OF THE DOSE SETTING |
KR1020177002285A KR20170026516A (en) | 2014-07-01 | 2015-07-01 | Injection device with compression spring for engaging ratchet elements, for biasing an actuation button, and for biasing a locking element into a dose setting mode |
MX2016017404A MX2016017404A (en) | 2014-07-01 | 2015-07-01 | Injection device with compression spring for engaging ratchet elements, for biasing an actuation button, and for biasing a locking element into a dose setting mode. |
EP15734640.4A EP3164181A1 (en) | 2014-07-01 | 2015-07-01 | Injection device with compression spring for engaging ratchet elements, for biasing an actuation button, and for biasing a locking element into a dose setting mode |
IL249677A IL249677A0 (en) | 2014-07-01 | 2016-12-21 | Injection device with compression spring for engaging ratchet elements, for biasing an actuation button, and for biasing a locking element into a dose setting mode |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14306062 | 2014-07-01 | ||
EP14306062.2 | 2014-07-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2016001293A1 true WO2016001293A1 (en) | 2016-01-07 |
Family
ID=51133966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2015/064967 WO2016001293A1 (en) | 2014-07-01 | 2015-07-01 | Injection device with compression spring for engaging ratchet elements, for biasing an actuation button, and for biasing a locking element into a dose setting mode |
Country Status (12)
Country | Link |
---|---|
US (1) | US10420889B2 (en) |
EP (1) | EP3164181A1 (en) |
JP (1) | JP2017520368A (en) |
KR (1) | KR20170026516A (en) |
CN (1) | CN106535965A (en) |
AR (1) | AR101029A1 (en) |
AU (1) | AU2015282975A1 (en) |
IL (1) | IL249677A0 (en) |
MX (1) | MX2016017404A (en) |
RU (1) | RU2016152234A (en) |
TW (1) | TW201611853A (en) |
WO (1) | WO2016001293A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018206494A1 (en) * | 2017-05-11 | 2018-11-15 | Novo Nordisk A/S | Piston rod brake mechanism |
CN112805049A (en) * | 2018-09-08 | 2021-05-14 | 榭利工程塑料有限公司 | Injection device |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10639417B2 (en) * | 2017-10-25 | 2020-05-05 | Carefusion 303, Inc. | Lever for auto insertion and secure placement of IV tubing for use in intravenous pump systems |
EP3545989A1 (en) * | 2018-03-28 | 2019-10-02 | Sanofi | Injection device |
EP3545995A1 (en) * | 2018-03-28 | 2019-10-02 | Sanofi | Injection device |
JP2022509409A (en) * | 2018-10-30 | 2022-01-20 | ノボ・ノルデイスク・エー/エス | Torsion spring driven injection device |
Citations (5)
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---|---|---|---|---|
WO2007063342A1 (en) * | 2005-12-02 | 2007-06-07 | Owen Mumford Limited | Injection method and apparatus |
WO2010020311A1 (en) * | 2008-08-18 | 2010-02-25 | Haselmeier Gmbh | Injection device having a dosing indicator for preventing false readings |
WO2012049139A1 (en) * | 2010-10-13 | 2012-04-19 | Sanofi-Aventis Deutschland Gmbh | Dose setting mechanism and method of setting a dose |
WO2013034651A1 (en) * | 2011-09-08 | 2013-03-14 | Menarini International Operations Luxembourg S.A. | Device for automatic injection of drug doses |
WO2013119132A1 (en) * | 2012-02-08 | 2013-08-15 | Copernicus Sp. Z O.O. | Injecting device with dose resetting mechanism |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2983752T3 (en) | 2013-04-10 | 2019-08-12 | Sanofi Sa | INJECTION DEVICE |
-
2015
- 2015-06-29 TW TW104120885A patent/TW201611853A/en unknown
- 2015-06-30 AR ARP150102085A patent/AR101029A1/en unknown
- 2015-07-01 KR KR1020177002285A patent/KR20170026516A/en unknown
- 2015-07-01 MX MX2016017404A patent/MX2016017404A/en unknown
- 2015-07-01 EP EP15734640.4A patent/EP3164181A1/en not_active Withdrawn
- 2015-07-01 US US15/321,870 patent/US10420889B2/en not_active Expired - Fee Related
- 2015-07-01 WO PCT/EP2015/064967 patent/WO2016001293A1/en active Application Filing
- 2015-07-01 AU AU2015282975A patent/AU2015282975A1/en not_active Abandoned
- 2015-07-01 CN CN201580030588.8A patent/CN106535965A/en active Pending
- 2015-07-01 JP JP2017519984A patent/JP2017520368A/en not_active Abandoned
- 2015-07-01 RU RU2016152234A patent/RU2016152234A/en not_active Application Discontinuation
-
2016
- 2016-12-21 IL IL249677A patent/IL249677A0/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007063342A1 (en) * | 2005-12-02 | 2007-06-07 | Owen Mumford Limited | Injection method and apparatus |
WO2010020311A1 (en) * | 2008-08-18 | 2010-02-25 | Haselmeier Gmbh | Injection device having a dosing indicator for preventing false readings |
WO2012049139A1 (en) * | 2010-10-13 | 2012-04-19 | Sanofi-Aventis Deutschland Gmbh | Dose setting mechanism and method of setting a dose |
WO2013034651A1 (en) * | 2011-09-08 | 2013-03-14 | Menarini International Operations Luxembourg S.A. | Device for automatic injection of drug doses |
WO2013119132A1 (en) * | 2012-02-08 | 2013-08-15 | Copernicus Sp. Z O.O. | Injecting device with dose resetting mechanism |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018206494A1 (en) * | 2017-05-11 | 2018-11-15 | Novo Nordisk A/S | Piston rod brake mechanism |
CN110582314A (en) * | 2017-05-11 | 2019-12-17 | 诺和诺德股份有限公司 | Piston rod brake mechanism |
JP2020519356A (en) * | 2017-05-11 | 2020-07-02 | ノボ・ノルデイスク・エー/エス | Piston rod brake mechanism |
JP7033611B2 (en) | 2017-05-11 | 2022-03-10 | ノボ・ノルデイスク・エー/エス | Piston rod brake mechanism |
CN110582314B (en) * | 2017-05-11 | 2022-04-05 | 诺和诺德股份有限公司 | Piston rod brake mechanism |
US11400225B2 (en) | 2017-05-11 | 2022-08-02 | Novo Nordisk A/S | Piston rod brake mechanism |
CN112805049A (en) * | 2018-09-08 | 2021-05-14 | 榭利工程塑料有限公司 | Injection device |
CN112805049B (en) * | 2018-09-08 | 2023-01-03 | 榭利工程塑料有限公司 | Injection device |
Also Published As
Publication number | Publication date |
---|---|
RU2016152234A (en) | 2018-08-01 |
EP3164181A1 (en) | 2017-05-10 |
US20170128670A1 (en) | 2017-05-11 |
RU2016152234A3 (en) | 2019-02-14 |
CN106535965A (en) | 2017-03-22 |
MX2016017404A (en) | 2017-05-01 |
KR20170026516A (en) | 2017-03-08 |
TW201611853A (en) | 2016-04-01 |
US10420889B2 (en) | 2019-09-24 |
AR101029A1 (en) | 2016-11-16 |
JP2017520368A (en) | 2017-07-27 |
AU2015282975A1 (en) | 2017-01-12 |
IL249677A0 (en) | 2017-02-28 |
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