WO2015131056A3 - Waveguide-based detection system with scanning light source - Google Patents

Waveguide-based detection system with scanning light source

Info

Publication number
WO2015131056A3
WO2015131056A3 PCT/US2015/018032 US2015018032W WO2015131056A3 WO 2015131056 A3 WO2015131056 A3 WO 2015131056A3 US 2015018032 W US2015018032 W US 2015018032W WO 2015131056 A3 WO2015131056 A3 WO 2015131056A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
light
scanning
substrate
source
optical
Prior art date
Application number
PCT/US2015/018032
Other languages
French (fr)
Other versions
WO2015131056A2 (en )
Inventor
Reuven Duer
Original Assignee
Indx Lifecare, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6452Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N2021/6484Optical fibres

Abstract

The invention provides methods and devices for generating optical pulses in one or more waveguides using a spatially scanning light source. A detection system, methods of use thereof and kits for detecting a biologically active analyte molecule are also provided. The system includes a scanning light source, a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more waveguide of the substrate, a detector that is coupled to and in optical communication with the substrate, and means for spatially translating a light beam emitted from said scanning light source such that the light beam is coupled to and in optical communication with the waveguides of the substrate at some point along its scanning path. The use of a scanning light source allows the coupling of light into the waveguides of the substrate in a simple and cost-effective manner.
PCT/US2015/018032 2006-03-10 2015-02-27 Waveguide-based detection system with scanning light source WO2015131056A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US14194437 US9423397B2 (en) 2006-03-10 2014-02-28 Waveguide-based detection system with scanning light source
US14/194,437 2014-02-28

Publications (2)

Publication Number Publication Date
WO2015131056A2 true WO2015131056A2 (en) 2015-09-03
WO2015131056A3 true true WO2015131056A3 (en) 2015-11-19

Family

ID=54009791

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/018032 WO2015131056A3 (en) 2006-03-10 2015-02-27 Waveguide-based detection system with scanning light source

Country Status (1)

Country Link
WO (1) WO2015131056A3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3175222A4 (en) * 2014-07-29 2018-04-04 Ldip Llc Partially encapsulated waveguide based sensing chips, systems and methods of use

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5671303A (en) * 1996-04-17 1997-09-23 Motorola, Inc. Molecular detection apparatus and method using optical waveguide detection
US6078705A (en) * 1995-05-12 2000-06-20 Novartis Ag Sensor platform and method for the parallel detection of a plurality of analytes using evanescently excited luminescence
JP2010160087A (en) * 2009-01-09 2010-07-22 Nitto Denko Corp Optical waveguide type chemical sensor
US20130215425A9 (en) * 2006-03-10 2013-08-22 Reuven Duer Waveguide-based detection system with scanning light source

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6078705A (en) * 1995-05-12 2000-06-20 Novartis Ag Sensor platform and method for the parallel detection of a plurality of analytes using evanescently excited luminescence
US5671303A (en) * 1996-04-17 1997-09-23 Motorola, Inc. Molecular detection apparatus and method using optical waveguide detection
US20130215425A9 (en) * 2006-03-10 2013-08-22 Reuven Duer Waveguide-based detection system with scanning light source
JP2010160087A (en) * 2009-01-09 2010-07-22 Nitto Denko Corp Optical waveguide type chemical sensor

Also Published As

Publication number Publication date Type
WO2015131056A2 (en) 2015-09-03 application

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